PMC:7556165 / 32861-33370 JSONTXT

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T73","span":{"begin":10,"end":13},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T74","span":{"begin":110,"end":113},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T75","span":{"begin":127,"end":130},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T76","span":{"begin":161,"end":164},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T77","span":{"begin":319,"end":333},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A73","pred":"meddra_id","subj":"T73","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A74","pred":"meddra_id","subj":"T74","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A77","pred":"meddra_id","subj":"T77","obj":"http://purl.bioontology.org/ontology/MEDDRA/10002491"},{"id":"A76","pred":"meddra_id","subj":"T76","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A75","pred":"meddra_id","subj":"T75","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T121","span":{"begin":319,"end":333},"obj":"Chemical"}],"attributes":[{"id":"A121","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A122","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A123","pred":"chebi_id","subj":"T121","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T90","span":{"begin":3,"end":8},"obj":"Species"},{"id":"T91","span":{"begin":379,"end":402},"obj":"Species"},{"id":"T92","span":{"begin":403,"end":407},"obj":"Species"},{"id":"T93","span":{"begin":412,"end":416},"obj":"Species"}],"attributes":[{"id":"A90","pred":"ncbi_taxonomy_id","subj":"T90","obj":"NCBItxid:9606"},{"id":"A91","pred":"ncbi_taxonomy_id","subj":"T91","obj":"NCBItxid:11309"},{"id":"A92","pred":"ncbi_taxonomy_id","subj":"T92","obj":"NCBItxid:102793"},{"id":"A93","pred":"ncbi_taxonomy_id","subj":"T93","obj":"NCBItxid:333278"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T202","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T203","span":{"begin":64,"end":288},"obj":"Sentence"},{"id":"T204","span":{"begin":289,"end":509},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"923","span":{"begin":10,"end":13},"obj":"Gene"},{"id":"924","span":{"begin":14,"end":18},"obj":"Gene"},{"id":"925","span":{"begin":110,"end":113},"obj":"Gene"},{"id":"926","span":{"begin":127,"end":130},"obj":"Gene"},{"id":"927","span":{"begin":161,"end":164},"obj":"Gene"},{"id":"928","span":{"begin":188,"end":192},"obj":"Gene"},{"id":"929","span":{"begin":319,"end":333},"obj":"Gene"},{"id":"930","span":{"begin":3,"end":8},"obj":"Species"},{"id":"931","span":{"begin":356,"end":364},"obj":"Species"},{"id":"932","span":{"begin":385,"end":402},"obj":"Species"},{"id":"933","span":{"begin":403,"end":407},"obj":"Species"},{"id":"934","span":{"begin":225,"end":229},"obj":"Disease"},{"id":"935","span":{"begin":249,"end":258},"obj":"Disease"},{"id":"936","span":{"begin":365,"end":373},"obj":"Disease"},{"id":"937","span":{"begin":414,"end":416},"obj":"CellLine"}],"attributes":[{"id":"A923","pred":"pubann:denotes","subj":"923","obj":"Gene:1636"},{"id":"A927","pred":"pubann:denotes","subj":"927","obj":"Gene:1636"},{"id":"A934","pred":"pubann:denotes","subj":"934","obj":"MESH:D012128"},{"id":"A928","pred":"pubann:denotes","subj":"928","obj":"Gene:59272"},{"id":"A932","pred":"pubann:denotes","subj":"932","obj":"Tax:11308"},{"id":"A929","pred":"pubann:denotes","subj":"929","obj":"Gene:183"},{"id":"A936","pred":"pubann:denotes","subj":"936","obj":"MESH:D007239"},{"id":"A935","pred":"pubann:denotes","subj":"935","obj":"MESH:D003643"},{"id":"A937","pred":"pubann:denotes","subj":"937","obj":"CVCL:0452"},{"id":"A933","pred":"pubann:denotes","subj":"933","obj":"Tax:102793"},{"id":"A926","pred":"pubann:denotes","subj":"926","obj":"Gene:1636"},{"id":"A930","pred":"pubann:denotes","subj":"930","obj":"Tax:9606"},{"id":"A931","pred":"pubann:denotes","subj":"931","obj":"Tax:9606"},{"id":"A924","pred":"pubann:denotes","subj":"924","obj":"Gene:59272"},{"id":"A925","pred":"pubann:denotes","subj":"925","obj":"Gene:1636"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

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human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T97","span":{"begin":230,"end":244},"obj":"http://purl.obolibrary.org/obo/IDO_0000467"},{"id":"T98","span":{"begin":365,"end":373},"obj":"http://purl.obolibrary.org/obo/IDO_0000586"},{"id":"T99","span":{"begin":395,"end":402},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T293","span":{"begin":114,"end":118},"obj":"Body_part"}],"attributes":[{"id":"A293","pred":"fma_id","subj":"T293","obj":"http://purl.org/sig/ont/fma/fma74402"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T93","span":{"begin":225,"end":229},"obj":"Disease"},{"id":"T94","span":{"begin":379,"end":394},"obj":"Disease"}],"attributes":[{"id":"A94","pred":"mondo_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/MONDO_0018695"},{"id":"A93","pred":"mondo_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"923","span":{"begin":10,"end":13},"obj":"Gene"},{"id":"924","span":{"begin":14,"end":18},"obj":"Gene"},{"id":"925","span":{"begin":110,"end":113},"obj":"Gene"},{"id":"926","span":{"begin":127,"end":130},"obj":"Gene"},{"id":"927","span":{"begin":161,"end":164},"obj":"Gene"},{"id":"928","span":{"begin":188,"end":192},"obj":"Gene"},{"id":"929","span":{"begin":319,"end":333},"obj":"Gene"},{"id":"930","span":{"begin":3,"end":8},"obj":"Species"},{"id":"931","span":{"begin":356,"end":364},"obj":"Species"},{"id":"932","span":{"begin":385,"end":402},"obj":"Species"},{"id":"933","span":{"begin":403,"end":407},"obj":"Species"},{"id":"934","span":{"begin":225,"end":229},"obj":"Disease"},{"id":"935","span":{"begin":249,"end":258},"obj":"Disease"},{"id":"936","span":{"begin":365,"end":373},"obj":"Disease"},{"id":"937","span":{"begin":414,"end":416},"obj":"CellLine"}],"attributes":[{"id":"A923","pred":"tao:has_database_id","subj":"923","obj":"Gene:1636"},{"id":"A924","pred":"tao:has_database_id","subj":"924","obj":"Gene:59272"},{"id":"A925","pred":"tao:has_database_id","subj":"925","obj":"Gene:1636"},{"id":"A926","pred":"tao:has_database_id","subj":"926","obj":"Gene:1636"},{"id":"A927","pred":"tao:has_database_id","subj":"927","obj":"Gene:1636"},{"id":"A928","pred":"tao:has_database_id","subj":"928","obj":"Gene:59272"},{"id":"A929","pred":"tao:has_database_id","subj":"929","obj":"Gene:183"},{"id":"A930","pred":"tao:has_database_id","subj":"930","obj":"Tax:9606"},{"id":"A931","pred":"tao:has_database_id","subj":"931","obj":"Tax:9606"},{"id":"A932","pred":"tao:has_database_id","subj":"932","obj":"Tax:11308"},{"id":"A933","pred":"tao:has_database_id","subj":"933","obj":"Tax:102793"},{"id":"A934","pred":"tao:has_database_id","subj":"934","obj":"MESH:D012128"},{"id":"A935","pred":"tao:has_database_id","subj":"935","obj":"MESH:D003643"},{"id":"A936","pred":"tao:has_database_id","subj":"936","obj":"MESH:D007239"},{"id":"A937","pred":"tao:has_database_id","subj":"937","obj":"CVCL:0452"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T202","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T203","span":{"begin":64,"end":288},"obj":"Sentence"},{"id":"T204","span":{"begin":289,"end":509},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In human, ACE/ACE2 imbalance may be related to genetic factors. In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002). More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014)."}