PMC:7556165 / 31889-32561 JSONTXT

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T197","span":{"begin":0,"end":250},"obj":"Sentence"},{"id":"T198","span":{"begin":251,"end":449},"obj":"Sentence"},{"id":"T199","span":{"begin":450,"end":672},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T131","span":{"begin":21,"end":25},"obj":"Body_part"}],"attributes":[{"id":"A131","pred":"uberon_id","subj":"T131","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"883","span":{"begin":0,"end":4},"obj":"Gene"},{"id":"884","span":{"begin":50,"end":54},"obj":"Gene"},{"id":"885","span":{"begin":569,"end":597},"obj":"Gene"},{"id":"886","span":{"begin":599,"end":605},"obj":"Gene"},{"id":"887","span":{"begin":21,"end":38},"obj":"Disease"},{"id":"888","span":{"begin":110,"end":125},"obj":"Disease"},{"id":"889","span":{"begin":174,"end":186},"obj":"Disease"},{"id":"890","span":{"begin":188,"end":196},"obj":"Disease"},{"id":"891","span":{"begin":370,"end":376},"obj":"Disease"}],"attributes":[{"id":"A885","pred":"pubann:denotes","subj":"885","obj":"Gene:7124"},{"id":"A889","pred":"pubann:denotes","subj":"889","obj":"MESH:D007249"},{"id":"A887","pred":"pubann:denotes","subj":"887","obj":"MESH:D011014"},{"id":"A884","pred":"pubann:denotes","subj":"884","obj":"Gene:116511"},{"id":"A891","pred":"pubann:denotes","subj":"891","obj":"MESH:D001249"},{"id":"A890","pred":"pubann:denotes","subj":"890","obj":"MESH:D005355"},{"id":"A883","pred":"pubann:denotes","subj":"883","obj":"Gene:59272"},{"id":"A888","pred":"pubann:denotes","subj":"888","obj":"MESH:D001249"},{"id":"A886","pred":"pubann:denotes","subj":"886","obj":"Gene:7039"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T2514","span":{"begin":0,"end":4},"obj":"Protein"},{"id":"T2515","span":{"begin":582,"end":595},"obj":"Protein"}],"attributes":[{"id":"A2514","pred":"uniprot_id","subj":"T2514","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2515","pred":"uniprot_id","subj":"T2515","obj":"https://www.uniprot.org/uniprot/Q8V307"},{"id":"A2516","pred":"uniprot_id","subj":"T2515","obj":"https://www.uniprot.org/uniprot/Q77PC4"},{"id":"A2517","pred":"uniprot_id","subj":"T2515","obj":"https://www.uniprot.org/uniprot/Q776B5"},{"id":"A2518","pred":"uniprot_id","subj":"T2515","obj":"https://www.uniprot.org/uniprot/Q6RZT5"},{"id":"A2519","pred":"uniprot_id","subj":"T2515","obj":"https://www.uniprot.org/uniprot/P08441"},{"id":"A2520","pred":"uniprot_id","subj":"T2515","obj":"https://www.uniprot.org/uniprot/P08072"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T94","span":{"begin":208,"end":213},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T95","span":{"begin":582,"end":588},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T283","span":{"begin":21,"end":25},"obj":"Body_part"},{"id":"T284","span":{"begin":134,"end":144},"obj":"Body_part"},{"id":"T285","span":{"begin":201,"end":213},"obj":"Body_part"},{"id":"T286","span":{"begin":208,"end":213},"obj":"Body_part"},{"id":"T287","span":{"begin":519,"end":527},"obj":"Body_part"}],"attributes":[{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma13148"},{"id":"A286","pred":"fma_id","subj":"T286","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A283","pred":"fma_id","subj":"T283","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A284","pred":"fma_id","subj":"T284","obj":"http://purl.org/sig/ont/fma/fma62861"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-PD-MONDO","denotations":[{"id":"T88","span":{"begin":26,"end":38},"obj":"Disease"},{"id":"T89","span":{"begin":110,"end":125},"obj":"Disease"},{"id":"T90","span":{"begin":174,"end":186},"obj":"Disease"},{"id":"T91","span":{"begin":370,"end":376},"obj":"Disease"}],"attributes":[{"id":"A88","pred":"mondo_id","subj":"T88","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A91","pred":"mondo_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/MONDO_0004979"},{"id":"A89","pred":"mondo_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/MONDO_0004784"},{"id":"A90","pred":"mondo_id","subj":"T90","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T121","span":{"begin":21,"end":25},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T81","span":{"begin":26,"end":38},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T82","span":{"begin":174,"end":186},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T83","span":{"begin":214,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0036074"},{"id":"T84","span":{"begin":582,"end":588},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T85","span":{"begin":616,"end":634},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T86","span":{"begin":616,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T34","span":{"begin":119,"end":125},"obj":"Phenotype"},{"id":"T35","span":{"begin":370,"end":376},"obj":"Phenotype"},{"id":"T36","span":{"begin":519,"end":533},"obj":"Phenotype"}],"attributes":[{"id":"A34","pred":"hp_id","subj":"T34","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A35","pred":"hp_id","subj":"T35","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A36","pred":"hp_id","subj":"T36","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T84","span":{"begin":26,"end":38},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T85","span":{"begin":174,"end":186},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T86","span":{"begin":214,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0036074"},{"id":"T87","span":{"begin":582,"end":588},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T88","span":{"begin":616,"end":634},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T89","span":{"begin":616,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T37","span":{"begin":119,"end":125},"obj":"Phenotype"},{"id":"T38","span":{"begin":370,"end":376},"obj":"Phenotype"},{"id":"T39","span":{"begin":519,"end":533},"obj":"Phenotype"}],"attributes":[{"id":"A37","pred":"hp_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A38","pred":"hp_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/HP_0002099"},{"id":"A39","pred":"hp_id","subj":"T39","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"883","span":{"begin":0,"end":4},"obj":"Gene"},{"id":"884","span":{"begin":50,"end":54},"obj":"Gene"},{"id":"885","span":{"begin":569,"end":597},"obj":"Gene"},{"id":"886","span":{"begin":599,"end":605},"obj":"Gene"},{"id":"887","span":{"begin":21,"end":38},"obj":"Disease"},{"id":"888","span":{"begin":110,"end":125},"obj":"Disease"},{"id":"889","span":{"begin":174,"end":186},"obj":"Disease"},{"id":"890","span":{"begin":188,"end":196},"obj":"Disease"},{"id":"891","span":{"begin":370,"end":376},"obj":"Disease"}],"attributes":[{"id":"A883","pred":"tao:has_database_id","subj":"883","obj":"Gene:59272"},{"id":"A884","pred":"tao:has_database_id","subj":"884","obj":"Gene:116511"},{"id":"A885","pred":"tao:has_database_id","subj":"885","obj":"Gene:7124"},{"id":"A886","pred":"tao:has_database_id","subj":"886","obj":"Gene:7039"},{"id":"A887","pred":"tao:has_database_id","subj":"887","obj":"MESH:D011014"},{"id":"A888","pred":"tao:has_database_id","subj":"888","obj":"MESH:D001249"},{"id":"A889","pred":"tao:has_database_id","subj":"889","obj":"MESH:D007249"},{"id":"A890","pred":"tao:has_database_id","subj":"890","obj":"MESH:D005355"},{"id":"A891","pred":"tao:has_database_id","subj":"891","obj":"MESH:D001249"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T197","span":{"begin":0,"end":250},"obj":"Sentence"},{"id":"T198","span":{"begin":251,"end":449},"obj":"Sentence"},{"id":"T199","span":{"begin":450,"end":672},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012). An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013). The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015)."}