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PMC:7556165 / 3126-3952 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T13 16-19 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T14 157-170 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T15 223-226 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T16 239-253 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T17 408-411 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T12 157-170 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T14 542-554 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T20 510-518 Species denotes SARS-CoV NCBItxid:694009
T21 510-514 Species denotes SARS NCBItxid:694009
T22 645-655 Species denotes SARS-CoV-2 NCBItxid:2697049
T23 645-649 Species denotes SARS NCBItxid:694009
T24 697-705 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T23 0-71 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 72-171 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 172-238 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 239-438 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 439-611 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 612-826 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
122 50-54 Gene denotes ACE2 Gene:59272
123 157-170 Gene denotes angiotensin I Gene:183
124 223-226 Gene denotes ACE Gene:1636
125 312-316 Gene denotes ACE2 Gene:59272
126 350-354 Gene denotes ACE2 Gene:59272
127 408-411 Gene denotes ACE Gene:1636
128 447-451 Gene denotes ACE2 Gene:59272
129 606-610 Gene denotes ACE2 Gene:59272
130 747-751 Gene denotes ACE2 Gene:59272
131 597-605 Gene denotes membrane Gene:43740571
132 510-518 Species denotes SARS-CoV Tax:694009
133 645-655 Species denotes SARS-CoV-2 Tax:2697049
134 16-19 Gene denotes ACE Gene:11421
135 697-705 Disease denotes COVID-19 MESH:C000657245

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T328 16-19 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T353 50-54 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T354 157-170 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T371 223-226 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T396 312-316 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T397 350-354 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T398 408-411 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T423 447-451 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T424 536-554 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T528 606-610 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T529 747-751 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T13 519-524 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T14 656-661 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 815-819 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T16 542-554 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T17 815-819 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T27 510-518 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 510-514 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T29 645-655 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T30 645-649 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T31 697-705 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T8 773-783 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T8 773-783 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
122 50-54 Gene denotes ACE2 Gene:59272
123 157-170 Gene denotes angiotensin I Gene:183
124 223-226 Gene denotes ACE Gene:1636
125 312-316 Gene denotes ACE2 Gene:59272
126 350-354 Gene denotes ACE2 Gene:59272
127 408-411 Gene denotes ACE Gene:1636
128 447-451 Gene denotes ACE2 Gene:59272
129 606-610 Gene denotes ACE2 Gene:59272
130 747-751 Gene denotes ACE2 Gene:59272
131 597-605 Gene denotes membrane Gene:43740571
132 510-518 Species denotes SARS-CoV Tax:694009
133 645-655 Species denotes SARS-CoV-2 Tax:2697049
134 16-19 Gene denotes ACE Gene:11421
135 697-705 Disease denotes COVID-19 MESH:C000657245

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T23 0-71 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 72-171 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 172-238 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 239-438 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 439-611 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 612-826 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.