PMC:7556165 / 30847-31153 JSONTXT

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T71","span":{"begin":122,"end":125},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T72","span":{"begin":130,"end":144},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A71","pred":"meddra_id","subj":"T71","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A72","pred":"meddra_id","subj":"T72","obj":"http://purl.bioontology.org/ontology/MEDDRA/10002491"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T116","span":{"begin":130,"end":144},"obj":"Chemical"}],"attributes":[{"id":"A116","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A117","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A118","pred":"chebi_id","subj":"T116","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T192","span":{"begin":0,"end":306},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T125","span":{"begin":29,"end":32},"obj":"Body_part"},{"id":"T126","span":{"begin":75,"end":79},"obj":"Body_part"},{"id":"T127","span":{"begin":170,"end":174},"obj":"Body_part"}],"attributes":[{"id":"A125","pred":"uberon_id","subj":"T125","obj":"http://purl.obolibrary.org/obo/UBERON_0001460"},{"id":"A126","pred":"uberon_id","subj":"T126","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A127","pred":"uberon_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

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{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T85","span":{"begin":80,"end":87},"obj":"http://purl.obolibrary.org/obo/OGMS_0000031"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T277","span":{"begin":29,"end":32},"obj":"Body_part"},{"id":"T278","span":{"begin":75,"end":79},"obj":"Body_part"},{"id":"T279","span":{"begin":170,"end":174},"obj":"Body_part"}],"attributes":[{"id":"A277","pred":"fma_id","subj":"T277","obj":"http://purl.org/sig/ont/fma/fma24890"},{"id":"A278","pred":"fma_id","subj":"T278","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A279","pred":"fma_id","subj":"T279","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

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{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T116","span":{"begin":75,"end":79},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"},{"id":"T117","span":{"begin":170,"end":174},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T24","span":{"begin":75,"end":87},"obj":"Phenotype"},{"id":"T25","span":{"begin":189,"end":207},"obj":"Phenotype"},{"id":"T26","span":{"begin":219,"end":231},"obj":"Phenotype"},{"id":"T27","span":{"begin":243,"end":263},"obj":"Phenotype"}],"attributes":[{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0002088"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/HP_0002206"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0002098"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T24","span":{"begin":75,"end":87},"obj":"Phenotype"},{"id":"T25","span":{"begin":164,"end":181},"obj":"Phenotype"},{"id":"T26","span":{"begin":183,"end":186},"obj":"Phenotype"},{"id":"T27","span":{"begin":189,"end":207},"obj":"Phenotype"},{"id":"T28","span":{"begin":219,"end":231},"obj":"Phenotype"},{"id":"T29","span":{"begin":243,"end":263},"obj":"Phenotype"}],"attributes":[{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0002088"},{"id":"A25","pred":"hp_id","subj":"T25","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A26","pred":"hp_id","subj":"T26","obj":"http://www.orpha.net/ORDO/Orphanet_178320"},{"id":"A27","pred":"hp_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/HP_0002206"},{"id":"A28","pred":"hp_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/HP_0000822"},{"id":"A29","pred":"hp_id","subj":"T29","obj":"http://purl.obolibrary.org/obo/HP_0002098"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"832","span":{"begin":24,"end":28},"obj":"Gene"},{"id":"833","span":{"begin":122,"end":125},"obj":"Gene"},{"id":"834","span":{"begin":130,"end":144},"obj":"Gene"},{"id":"836","span":{"begin":75,"end":87},"obj":"Disease"},{"id":"837","span":{"begin":164,"end":181},"obj":"Disease"},{"id":"838","span":{"begin":189,"end":207},"obj":"Disease"},{"id":"839","span":{"begin":209,"end":231},"obj":"Disease"},{"id":"840","span":{"begin":237,"end":272},"obj":"Disease"},{"id":"841","span":{"begin":274,"end":278},"obj":"Disease"}],"attributes":[{"id":"A832","pred":"tao:has_database_id","subj":"832","obj":"Gene:59272"},{"id":"A833","pred":"tao:has_database_id","subj":"833","obj":"Gene:1636"},{"id":"A834","pred":"tao:has_database_id","subj":"834","obj":"Gene:183"},{"id":"A836","pred":"tao:has_database_id","subj":"836","obj":"MESH:D008171"},{"id":"A837","pred":"tao:has_database_id","subj":"837","obj":"MESH:D055371"},{"id":"A838","pred":"tao:has_database_id","subj":"838","obj":"MESH:D011658"},{"id":"A839","pred":"tao:has_database_id","subj":"839","obj":"MESH:D006976"},{"id":"A840","pred":"tao:has_database_id","subj":"840","obj":"MESH:D012128"},{"id":"A841","pred":"tao:has_database_id","subj":"841","obj":"MESH:D012128"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010)."}

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