PMC:7556165 / 27322-27637 JSONTXT

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T67","span":{"begin":60,"end":73},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T68","span":{"begin":151,"end":154},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A67","pred":"meddra_id","subj":"T67","obj":"http://purl.bioontology.org/ontology/MEDDRA/10002484"},{"id":"A68","pred":"meddra_id","subj":"T68","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T96","span":{"begin":60,"end":73},"obj":"Chemical"},{"id":"T98","span":{"begin":288,"end":298},"obj":"Chemical"}],"attributes":[{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_147350"},{"id":"A97","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_2718"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T174","span":{"begin":156,"end":259},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T118","span":{"begin":218,"end":224},"obj":"Body_part"},{"id":"T119","span":{"begin":236,"end":241},"obj":"Body_part"},{"id":"T120","span":{"begin":243,"end":250},"obj":"Body_part"}],"attributes":[{"id":"A118","pred":"uberon_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A119","pred":"uberon_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A120","pred":"uberon_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/UBERON_0000055"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"720","span":{"begin":21,"end":27},"obj":"Gene"},{"id":"721","span":{"begin":60,"end":73},"obj":"Gene"},{"id":"722","span":{"begin":151,"end":154},"obj":"Gene"},{"id":"723","span":{"begin":260,"end":264},"obj":"Gene"},{"id":"724","span":{"begin":304,"end":309},"obj":"Gene"},{"id":"725","span":{"begin":173,"end":177},"obj":"Gene"}],"attributes":[{"id":"A720","pred":"pubann:denotes","subj":"720","obj":"Gene:24179"},{"id":"A721","pred":"pubann:denotes","subj":"721","obj":"Gene:183"},{"id":"A722","pred":"pubann:denotes","subj":"722","obj":"Gene:1636"},{"id":"A723","pred":"pubann:denotes","subj":"723","obj":"Gene:59272"},{"id":"A724","pred":"pubann:denotes","subj":"724","obj":"Gene:623"},{"id":"A725","pred":"pubann:denotes","subj":"725","obj":"Gene:116511"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T2123","span":{"begin":32,"end":36},"obj":"Protein"},{"id":"T2133","span":{"begin":60,"end":73},"obj":"Protein"},{"id":"T2150","span":{"begin":141,"end":145},"obj":"Protein"},{"id":"T2160","span":{"begin":151,"end":154},"obj":"Protein"},{"id":"T2185","span":{"begin":156,"end":160},"obj":"Protein"},{"id":"T2195","span":{"begin":260,"end":264},"obj":"Protein"},{"id":"T2196","span":{"begin":288,"end":298},"obj":"Protein"}],"attributes":[{"id":"A2123","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q9BDY8"},{"id":"A2124","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q8K4Q4"},{"id":"A2125","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q6NWV7"},{"id":"A2126","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q60FC1"},{"id":"A2127","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q5HYA0"},{"id":"A2128","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q15389"},{"id":"A2129","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q08DP8"},{"id":"A2130","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/O35460"},{"id":"A2131","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/O18920"},{"id":"A2132","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/O08538"},{"id":"A2133","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q9TSZ0"},{"id":"A2134","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q9GLP7"},{"id":"A2135","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q9GLP6"},{"id":"A2136","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q9GLN8"},{"id":"A2137","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q96F91"},{"id":"A2138","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q16359"},{"id":"A2139","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q16358"},{"id":"A2140","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P67886"},{"id":"A2141","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P67885"},{"id":"A2142","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P20757"},{"id":"A2143","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P11859"},{"id":"A2144","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01019"},{"id":"A2145","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01018"},{"id":"A2146","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01017"},{"id":"A2147","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01016"},{"id":"A2148","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01015"},{"id":"A2149","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/A0A3Q1LGY9"},{"id":"A2150","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q9BDY8"},{"id":"A2151","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q8K4Q4"},{"id":"A2152","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q6NWV7"},{"id":"A2153","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q60FC1"},{"id":"A2154","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q5HYA0"},{"id":"A2155","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q15389"},{"id":"A2156","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q08DP8"},{"id":"A2157","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/O35460"},{"id":"A2158","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/O18920"},{"id":"A2159","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/O08538"},{"id":"A2160","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A2161","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A2162","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A2163","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A2164","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A2165","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A2166","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A2167","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A2168","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A2169","pred":"uniprot_id","su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converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T75","span":{"begin":218,"end":224},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T254","span":{"begin":236,"end":241},"obj":"Body_part"},{"id":"T255","span":{"begin":252,"end":257},"obj":"Body_part"},{"id":"T256","span":{"begin":310,"end":314},"obj":"Body_part"}],"attributes":[{"id":"A254","pred":"fma_id","subj":"T254","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A256","pred":"fma_id","subj":"T256","obj":"http://purl.org/sig/ont/fma/fma12520"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T103","span":{"begin":236,"end":241},"obj":"http://purl.obolibrary.org/obo/MAT_0000036"},{"id":"T104","span":{"begin":243,"end":250},"obj":"http://purl.obolibrary.org/obo/MAT_0000393"},{"id":"T105","span":{"begin":252,"end":257},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-PubTator","denotations":[{"id":"720","span":{"begin":21,"end":27},"obj":"Gene"},{"id":"721","span":{"begin":60,"end":73},"obj":"Gene"},{"id":"722","span":{"begin":151,"end":154},"obj":"Gene"},{"id":"723","span":{"begin":260,"end":264},"obj":"Gene"},{"id":"724","span":{"begin":304,"end":309},"obj":"Gene"},{"id":"725","span":{"begin":173,"end":177},"obj":"Gene"}],"attributes":[{"id":"A720","pred":"tao:has_database_id","subj":"720","obj":"Gene:24179"},{"id":"A721","pred":"tao:has_database_id","subj":"721","obj":"Gene:183"},{"id":"A722","pred":"tao:has_database_id","subj":"722","obj":"Gene:1636"},{"id":"A723","pred":"tao:has_database_id","subj":"723","obj":"Gene:59272"},{"id":"A724","pred":"tao:has_database_id","subj":"724","obj":"Gene:623"},{"id":"A725","pred":"tao:has_database_id","subj":"725","obj":"Gene:116511"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}

{"project":"LitCovid-sentences","denotations":[{"id":"T174","span":{"begin":156,"end":259},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"y converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis:"}