PMC:7556165 / 27244-27720 JSONTXT

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T67","span":{"begin":138,"end":151},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T68","span":{"begin":229,"end":232},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A67","pred":"meddra_id","subj":"T67","obj":"http://purl.bioontology.org/ontology/MEDDRA/10002484"},{"id":"A68","pred":"meddra_id","subj":"T68","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T96","span":{"begin":138,"end":151},"obj":"Chemical"},{"id":"T98","span":{"begin":366,"end":376},"obj":"Chemical"}],"attributes":[{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_147350"},{"id":"A97","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_2718"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_3165"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T173","span":{"begin":0,"end":233},"obj":"Sentence"},{"id":"T174","span":{"begin":234,"end":337},"obj":"Sentence"},{"id":"T175","span":{"begin":338,"end":476},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T118","span":{"begin":296,"end":302},"obj":"Body_part"},{"id":"T119","span":{"begin":314,"end":319},"obj":"Body_part"},{"id":"T120","span":{"begin":321,"end":328},"obj":"Body_part"}],"attributes":[{"id":"A118","pred":"uberon_id","subj":"T118","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A119","pred":"uberon_id","subj":"T119","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"A120","pred":"uberon_id","subj":"T120","obj":"http://purl.obolibrary.org/obo/UBERON_0000055"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"718","span":{"begin":10,"end":14},"obj":"Gene"},{"id":"719","span":{"begin":36,"end":40},"obj":"Gene"},{"id":"720","span":{"begin":99,"end":105},"obj":"Gene"},{"id":"721","span":{"begin":138,"end":151},"obj":"Gene"},{"id":"722","span":{"begin":229,"end":232},"obj":"Gene"},{"id":"723","span":{"begin":338,"end":342},"obj":"Gene"},{"id":"724","span":{"begin":382,"end":387},"obj":"Gene"},{"id":"725","span":{"begin":251,"end":255},"obj":"Gene"}],"attributes":[{"id":"A718","pred":"pubann:denotes","subj":"718","obj":"Gene:59272"},{"id":"A725","pred":"pubann:denotes","subj":"725","obj":"Gene:116511"},{"id":"A719","pred":"pubann:denotes","subj":"719","obj":"Gene:59272"},{"id":"A724","pred":"pubann:denotes","subj":"724","obj":"Gene:623"},{"id":"A723","pred":"pubann:denotes","subj":"723","obj":"Gene:59272"},{"id":"A720","pred":"pubann:denotes","subj":"720","obj":"Gene:24179"},{"id":"A722","pred":"pubann:denotes","subj":"722","obj":"Gene:1636"},{"id":"A721","pred":"pubann:denotes","subj":"721","obj":"Gene:183"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T2120","span":{"begin":10,"end":14},"obj":"Protein"},{"id":"T2121","span":{"begin":36,"end":40},"obj":"Protein"},{"id":"T2122","span":{"begin":54,"end":70},"obj":"Protein"},{"id":"T2123","span":{"begin":110,"end":114},"obj":"Protein"},{"id":"T2133","span":{"begin":138,"end":151},"obj":"Protein"},{"id":"T2150","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T2160","span":{"begin":229,"end":232},"obj":"Protein"},{"id":"T2185","span":{"begin":234,"end":238},"obj":"Protein"},{"id":"T2195","span":{"begin":338,"end":342},"obj":"Protein"},{"id":"T2196","span":{"begin":366,"end":376},"obj":"Protein"}],"attributes":[{"id":"A2120","pred":"uniprot_id","subj":"T2120","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2121","pred":"uniprot_id","subj":"T2121","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2122","pred":"uniprot_id","subj":"T2122","obj":"https://www.uniprot.org/uniprot/P86516"},{"id":"A2123","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q9BDY8"},{"id":"A2124","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q8K4Q4"},{"id":"A2125","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q6NWV7"},{"id":"A2126","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q60FC1"},{"id":"A2127","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q5HYA0"},{"id":"A2128","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q15389"},{"id":"A2129","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/Q08DP8"},{"id":"A2130","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/O35460"},{"id":"A2131","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/O18920"},{"id":"A2132","pred":"uniprot_id","subj":"T2123","obj":"https://www.uniprot.org/uniprot/O08538"},{"id":"A2133","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q9TSZ0"},{"id":"A2134","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q9GLP7"},{"id":"A2135","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q9GLP6"},{"id":"A2136","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q9GLN8"},{"id":"A2137","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q96F91"},{"id":"A2138","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q16359"},{"id":"A2139","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/Q16358"},{"id":"A2140","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P67886"},{"id":"A2141","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P67885"},{"id":"A2142","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P20757"},{"id":"A2143","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P11859"},{"id":"A2144","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01019"},{"id":"A2145","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01018"},{"id":"A2146","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01017"},{"id":"A2147","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01016"},{"id":"A2148","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/P01015"},{"id":"A2149","pred":"uniprot_id","subj":"T2133","obj":"https://www.uniprot.org/uniprot/A0A3Q1LGY9"},{"id":"A2150","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q9BDY8"},{"id":"A2151","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q8K4Q4"},{"id":"A2152","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q6NWV7"},{"id":"A2153","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q60FC1"},{"id":"A2154","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q5HYA0"},{"id":"A2155","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q15389"},{"id":"A2156","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/Q08DP8"},{"id":"A2157","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/O35460"},{"id":"A2158","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/O18920"},{"id":"A2159","pred":"uniprot_id","subj":"T2150","obj":"https://www.uniprot.org/uniprot/O08538"},{"id":"A2160","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A2161","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A2162","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A2163","pred":"uniprot_id","subj":"T2160","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A2164","pred":"uniprot_id","subj":"T2160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d":"A2216","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P83060"},{"id":"A2217","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P83055"},{"id":"A2218","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P0DM76"},{"id":"A2219","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P08934"},{"id":"A2220","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P08933"},{"id":"A2221","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P01047"},{"id":"A2222","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P01046"},{"id":"A2223","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P01045"},{"id":"A2224","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P01044"},{"id":"A2225","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P01043"},{"id":"A2226","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/P01042"},{"id":"A2227","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/O08677"},{"id":"A2228","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/O08676"},{"id":"A2229","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/C9JEX1"},{"id":"A2230","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/B2RCR2"},{"id":"A2231","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/A8K474"},{"id":"A2232","pred":"uniprot_id","subj":"T2196","obj":"https://www.uniprot.org/uniprot/A0A088MIT0"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T75","span":{"begin":296,"end":302},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T254","span":{"begin":314,"end":319},"obj":"Body_part"},{"id":"T255","span":{"begin":330,"end":335},"obj":"Body_part"},{"id":"T256","span":{"begin":388,"end":392},"obj":"Body_part"},{"id":"T257","span":{"begin":429,"end":433},"obj":"Body_part"},{"id":"T258","span":{"begin":461,"end":469},"obj":"Body_part"}],"attributes":[{"id":"A257","pred":"fma_id","subj":"T257","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A256","pred":"fma_id","subj":"T256","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A258","pred":"fma_id","subj":"T258","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A255","pred":"fma_id","subj":"T255","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A254","pred":"fma_id","subj":"T254","obj":"http://purl.org/sig/ont/fma/fma7088"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T103","span":{"begin":314,"end":319},"obj":"http://purl.obolibrary.org/obo/MAT_0000036"},{"id":"T104","span":{"begin":321,"end":328},"obj":"http://purl.obolibrary.org/obo/MAT_0000393"},{"id":"T105","span":{"begin":330,"end":335},"obj":"http://purl.obolibrary.org/obo/MAT_0000135"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T69","span":{"begin":15,"end":34},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T70","span":{"begin":15,"end":25},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T71","span":{"begin":54,"end":79},"obj":"http://purl.obolibrary.org/obo/GO_0004180"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-PD-HP","denotations":[{"id":"T17","span":{"begin":461,"end":475},"obj":"Phenotype"}],"attributes":[{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T71","span":{"begin":15,"end":34},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T72","span":{"begin":15,"end":25},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T73","span":{"begin":54,"end":79},"obj":"http://purl.obolibrary.org/obo/GO_0004180"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T17","span":{"begin":461,"end":475},"obj":"Phenotype"}],"attributes":[{"id":"A17","pred":"hp_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/HP_0033041"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-PubTator","denotations":[{"id":"718","span":{"begin":10,"end":14},"obj":"Gene"},{"id":"719","span":{"begin":36,"end":40},"obj":"Gene"},{"id":"720","span":{"begin":99,"end":105},"obj":"Gene"},{"id":"721","span":{"begin":138,"end":151},"obj":"Gene"},{"id":"722","span":{"begin":229,"end":232},"obj":"Gene"},{"id":"723","span":{"begin":338,"end":342},"obj":"Gene"},{"id":"724","span":{"begin":382,"end":387},"obj":"Gene"},{"id":"725","span":{"begin":251,"end":255},"obj":"Gene"}],"attributes":[{"id":"A718","pred":"tao:has_database_id","subj":"718","obj":"Gene:59272"},{"id":"A719","pred":"tao:has_database_id","subj":"719","obj":"Gene:59272"},{"id":"A720","pred":"tao:has_database_id","subj":"720","obj":"Gene:24179"},{"id":"A721","pred":"tao:has_database_id","subj":"721","obj":"Gene:183"},{"id":"A722","pred":"tao:has_database_id","subj":"722","obj":"Gene:1636"},{"id":"A723","pred":"tao:has_database_id","subj":"723","obj":"Gene:59272"},{"id":"A724","pred":"tao:has_database_id","subj":"724","obj":"Gene:623"},{"id":"A725","pred":"tao:has_database_id","subj":"725","obj":"Gene:116511"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}

{"project":"LitCovid-sentences","denotations":[{"id":"T173","span":{"begin":0,"end":233},"obj":"Sentence"},{"id":"T174","span":{"begin":234,"end":337},"obj":"Sentence"},{"id":"T175","span":{"begin":338,"end":476},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE. ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs). ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm."}