PMC:7556165 / 25984-26388 JSONTXT

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    LitCovid-sample-MedDRA

    {"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T61","span":{"begin":55,"end":67},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T62","span":{"begin":134,"end":137},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T63","span":{"begin":186,"end":200},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A61","pred":"meddra_id","subj":"T61","obj":"http://purl.bioontology.org/ontology/MEDDRA/10062026"},{"id":"A62","pred":"meddra_id","subj":"T62","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A63","pred":"meddra_id","subj":"T63","obj":"http://purl.bioontology.org/ontology/MEDDRA/10002491"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-sample-CHEBI

    {"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T91","span":{"begin":186,"end":200},"obj":"Chemical"}],"attributes":[{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_2719"},{"id":"A92","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_48432"},{"id":"A93","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_58506"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-sample-PD-NCBITaxon

    {"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T77","span":{"begin":303,"end":308},"obj":"Species"}],"attributes":[{"id":"A77","pred":"ncbi_taxonomy_id","subj":"T77","obj":"NCBItxid:10090"},{"id":"A78","pred":"ncbi_taxonomy_id","subj":"T77","obj":"NCBItxid:10088"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-sample-sentences

    {"project":"LitCovid-sample-sentences","denotations":[{"id":"T166","span":{"begin":4,"end":210},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-sample-Pubtator

    {"project":"LitCovid-sample-Pubtator","denotations":[{"id":"690","span":{"begin":18,"end":22},"obj":"Gene"},{"id":"691","span":{"begin":112,"end":116},"obj":"Gene"},{"id":"692","span":{"begin":134,"end":137},"obj":"Gene"},{"id":"693","span":{"begin":186,"end":200},"obj":"Gene"},{"id":"694","span":{"begin":235,"end":239},"obj":"Gene"},{"id":"695","span":{"begin":316,"end":320},"obj":"Gene"},{"id":"698","span":{"begin":303,"end":308},"obj":"Species"},{"id":"699","span":{"begin":283,"end":293},"obj":"Species"}],"attributes":[{"id":"A693","pred":"pubann:denotes","subj":"693","obj":"Gene:183"},{"id":"A692","pred":"pubann:denotes","subj":"692","obj":"Gene:1636"},{"id":"A691","pred":"pubann:denotes","subj":"691","obj":"Gene:59272"},{"id":"A698","pred":"pubann:denotes","subj":"698","obj":"Tax:10090"},{"id":"A690","pred":"pubann:denotes","subj":"690","obj":"Gene:59272"},{"id":"A699","pred":"pubann:denotes","subj":"699","obj":"Tax:10090"},{"id":"A695","pred":"pubann:denotes","subj":"695","obj":"Gene:70008"},{"id":"A694","pred":"pubann:denotes","subj":"694","obj":"Gene:70008"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-sample-UniProt

    {"project":"LitCovid-sample-UniProt","denotations":[{"id":"T2003","span":{"begin":18,"end":22},"obj":"Protein"},{"id":"T2004","span":{"begin":112,"end":116},"obj":"Protein"},{"id":"T2005","span":{"begin":134,"end":137},"obj":"Protein"},{"id":"T2030","span":{"begin":186,"end":200},"obj":"Protein"},{"id":"T2047","span":{"begin":235,"end":239},"obj":"Protein"},{"id":"T2048","span":{"begin":316,"end":320},"obj":"Protein"}],"attributes":[{"id":"A2003","pred":"uniprot_id","subj":"T2003","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2004","pred":"uniprot_id","subj":"T2004","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2005","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A2006","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A2007","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A2008","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A2009","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A2010","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A2011","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A2012","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A2013","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A2014","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q50JE5"},{"id":"A2015","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q10751"},{"id":"A2016","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q0GA41"},{"id":"A2017","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/P47820"},{"id":"A2018","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/P22968"},{"id":"A2019","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/P22967"},{"id":"A2020","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/P22966"},{"id":"A2021","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/P12822"},{"id":"A2022","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/P12821"},{"id":"A2023","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/P12820"},{"id":"A2024","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/P09470"},{"id":"A2025","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/O02852"},{"id":"A2026","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/E7EU16"},{"id":"A2027","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/B4DXI3"},{"id":"A2028","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/B0LPF0"},{"id":"A2029","pred":"uniprot_id","subj":"T2005","obj":"https://www.uniprot.org/uniprot/Q9VJV3"},{"id":"A2030","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/Q9TSZ0"},{"id":"A2031","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/Q9GLP7"},{"id":"A2032","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/Q9GLP6"},{"id":"A2033","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/Q9GLN8"},{"id":"A2034","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/Q96F91"},{"id":"A2035","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/Q16359"},{"id":"A2036","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/Q16358"},{"id":"A2037","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P67886"},{"id":"A2038","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P67885"},{"id":"A2039","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P20757"},{"id":"A2040","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P11859"},{"id":"A2041","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P01019"},{"id":"A2042","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P01018"},{"id":"A2043","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P01017"},{"id":"A2044","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P01016"},{"id":"A2045","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/P01015"},{"id":"A2046","pred":"uniprot_id","subj":"T2030","obj":"https://www.uniprot.org/uniprot/A0A3Q1LGY9"},{"id":"A2047","pred":"uniprot_id","subj":"T2047","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A2048","pred":"uniprot_id","subj":"T2048","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-sample-PD-GO-BP-0

    {"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T66","span":{"begin":75,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T67","span":{"begin":159,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0042310"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-sample-GO-BP

    {"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T68","span":{"begin":75,"end":85},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T69","span":{"begin":159,"end":175},"obj":"http://purl.obolibrary.org/obo/GO_0042310"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-PubTator

    {"project":"LitCovid-PubTator","denotations":[{"id":"690","span":{"begin":18,"end":22},"obj":"Gene"},{"id":"691","span":{"begin":112,"end":116},"obj":"Gene"},{"id":"692","span":{"begin":134,"end":137},"obj":"Gene"},{"id":"693","span":{"begin":186,"end":200},"obj":"Gene"},{"id":"694","span":{"begin":235,"end":239},"obj":"Gene"},{"id":"695","span":{"begin":316,"end":320},"obj":"Gene"},{"id":"698","span":{"begin":303,"end":308},"obj":"Species"},{"id":"699","span":{"begin":283,"end":293},"obj":"Species"}],"attributes":[{"id":"A690","pred":"tao:has_database_id","subj":"690","obj":"Gene:59272"},{"id":"A691","pred":"tao:has_database_id","subj":"691","obj":"Gene:59272"},{"id":"A692","pred":"tao:has_database_id","subj":"692","obj":"Gene:1636"},{"id":"A693","pred":"tao:has_database_id","subj":"693","obj":"Gene:183"},{"id":"A694","pred":"tao:has_database_id","subj":"694","obj":"Gene:70008"},{"id":"A695","pred":"tao:has_database_id","subj":"695","obj":"Gene:70008"},{"id":"A698","pred":"tao:has_database_id","subj":"698","obj":"Tax:10090"},{"id":"A699","pred":"tao:has_database_id","subj":"699","obj":"Tax:10090"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T166","span":{"begin":4,"end":210},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"5). The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II). The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinn"}