> top > docs > PMC:7556165 > spans > 2579-78705 > annotations

PMC:7556165 / 2579-78705 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T7 13-42 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T8 44-47 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T9 162-175 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T10 238-241 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T11 342-345 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T12 478-481 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T13 563-566 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T14 704-717 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T15 770-773 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T16 786-800 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T17 955-958 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T18 2059-2073 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T19 2076-2079 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T20 2112-2141 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T21 2143-2146 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T22 2294-2297 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T23 2318-2321 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T24 2471-2474 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T25 2591-2594 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T26 2676-2681 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes renin http://purl.bioontology.org/ontology/MEDDRA/10038555
T27 2839-2842 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T28 2968-2981 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T29 3032-3035 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T30 3129-3142 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T31 3155-3169 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T32 3255-3258 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T33 3377-3380 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T34 3499-3502 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T35 3778-3781 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T36 3937-3940 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T37 4149-4152 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T38 4477-4480 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T39 4750-4753 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T40 4781-4784 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T41 5305-5308 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T42 5395-5398 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T43 5849-5852 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T44 5934-5937 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T45 6064-6077 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T46 6081-6095 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T47 6161-6164 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T48 7132-7135 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T49 7343-7346 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T50 7564-7567 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T51 8885-8894 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes estradiol http://purl.bioontology.org/ontology/MEDDRA/10030227
T52 9580-9583 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T53 9623-9628 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes renin http://purl.bioontology.org/ontology/MEDDRA/10038555
T54 9853-9856 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T55 13277-13286 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Vitamin D http://purl.bioontology.org/ontology/MEDDRA/10050713
T56 13356-13365 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Vitamin D http://purl.bioontology.org/ontology/MEDDRA/10050713
T57 13579-13588 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Vitamin D http://purl.bioontology.org/ontology/MEDDRA/10050713
T58 13704-13707 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T59 14002-14005 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T60 18825-18845 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunohistochemistry http://purl.bioontology.org/ontology/MEDDRA/10059656
T61 23460-23472 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T62 23539-23542 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T63 23591-23605 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T64 23899-23902 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T65 24272-24285 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T66 24364-24367 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T67 24803-24816 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T68 24894-24897 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T69 26956-26959 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T70 27929-27932 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T71 28390-28393 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T72 28398-28412 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T73 30292-30295 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T74 30392-30395 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T75 30409-30412 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T76 30443-30446 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T77 30601-30615 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T78 32857-32862 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes lipid http://purl.bioontology.org/ontology/MEDDRA/10024587
T79 42857-42867 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes microscopy http://purl.bioontology.org/ontology/MEDDRA/10069374
T80 43243-43255 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T81 43280-43285 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes X-ray http://purl.bioontology.org/ontology/MEDDRA/10048064
T82 44365-44377 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T83 44859-44871 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T84 46267-46280 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes protein and S http://purl.bioontology.org/ontology/MEDDRA/10050417

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T6 13-24 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T7 100-108 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T8 113-121 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T9 162-175 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T11 180-190 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T12 704-717 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T14 1089-1101 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T15 2112-2123 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T16 2433-2440 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 2682-2693 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T18 2694-2705 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T20 2951-2959 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T21 2968-2981 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T23 2986-2996 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T24 3068-3079 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T25 3129-3142 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T27 3155-3169 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T30 3301-3311 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T31 3348-3355 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T32 3444-3448 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T34 4214-4231 Chemical denotes glutamate residue http://purl.obolibrary.org/obo/CHEBI_32484
T35 4245-4249 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T37 4711-4715 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T39 4767-4774 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T40 4825-4832 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T41 5733-5737 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T43 5762-5773 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T44 5986-5996 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T45 6064-6077 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T47 6081-6095 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T50 6116-6126 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T51 6182-6192 Chemical denotes lisinopril http://purl.obolibrary.org/obo/CHEBI_43755
T52 6197-6206 Chemical denotes captopril http://purl.obolibrary.org/obo/CHEBI_3380
T53 6591-6598 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T54 7289-7299 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T55 7616-7623 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T56 7646-7657 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T57 7876-7884 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365
T58 8317-8321 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T59 8885-8894 Chemical denotes estradiol http://purl.obolibrary.org/obo/CHEBI_23965
T60 8922-8929 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T61 9189-9193 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T62 9584-9591 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T63 9629-9640 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T64 10627-10634 Chemical denotes histone http://purl.obolibrary.org/obo/CHEBI_15358
T65 10810-10817 Chemical denotes histone http://purl.obolibrary.org/obo/CHEBI_15358
T66 11114-11122 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T67 11337-11340 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T68 11604-11611 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T69 12326-12333 Chemical denotes Histone http://purl.obolibrary.org/obo/CHEBI_15358
T70 12421-12424 Chemical denotes NAD http://purl.obolibrary.org/obo/CHEBI_13389|http://purl.obolibrary.org/obo/CHEBI_15846
T72 12670-12673 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T73 12699-12702 Chemical denotes CpG http://purl.obolibrary.org/obo/CHEBI_165823
T74 13277-13286 Chemical denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T75 13356-13365 Chemical denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T76 13579-13588 Chemical denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T77 13771-13779 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T78 14110-14114 Chemical denotes mRNA http://purl.obolibrary.org/obo/CHEBI_33699
T79 14378-14382 Chemical denotes mRNA http://purl.obolibrary.org/obo/CHEBI_33699
T80 15835-15842 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 16153-16160 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T82 17884-17891 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T83 18924-18927 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T84 19341-19348 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T85 19451-19454 Chemical denotes cat http://purl.obolibrary.org/obo/CHEBI_149681|http://purl.obolibrary.org/obo/CHEBI_32402
T87 20063-20070 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 21370-21373 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T89 21787-21791 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T90 21994-22001 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 23591-23605 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T94 24272-24285 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T96 24803-24816 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T98 25031-25041 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T99 25585-25597 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T100 26386-26397 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T101 26589-26596 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T102 26597-26600 Chemical denotes Ala http://purl.obolibrary.org/obo/CHEBI_16977|http://purl.obolibrary.org/obo/CHEBI_46217
T104 26709-26716 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T105 26983-26993 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T106 27025-27035 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T107 27056-27066 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T108 27116-27126 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T109 27213-27222 Chemical denotes apelin-13 http://purl.obolibrary.org/obo/CHEBI_147395|http://purl.obolibrary.org/obo/CHEBI_80131
T111 27227-27238 Chemical denotes neurotensin http://purl.obolibrary.org/obo/CHEBI_147362|http://purl.obolibrary.org/obo/CHEBI_7542
T113 27240-27251 Chemical denotes dynorphin A http://purl.obolibrary.org/obo/CHEBI_4727
T114 27264-27271 Chemical denotes ghrelin http://purl.obolibrary.org/obo/CHEBI_75431
T115 27302-27310 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T116 28398-28412 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T119 30034-30044 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T120 30201-30206 Chemical denotes CXCL5 http://purl.obolibrary.org/obo/CHEBI_138180
T121 30601-30615 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T124 31135-31138 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T125 31304-31316 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T126 31631-31643 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T127 32690-32697 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T128 32737-32745 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T129 32814-32822 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T130 32830-32838 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T131 32857-32862 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T132 33039-33046 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T133 33062-33067 Chemical denotes crown http://purl.obolibrary.org/obo/CHEBI_37409
T134 33159-33171 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T135 33344-33351 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T136 33571-33578 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T137 33961-33968 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 34003-34010 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T139 34748-34755 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T140 34851-34858 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T141 34936-34943 Chemical denotes glycine http://purl.obolibrary.org/obo/CHEBI_15428|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_57305
T144 34951-34958 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T145 35368-35376 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T146 36577-36584 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T147 37259-37266 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T148 38689-38696 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 39343-39350 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T150 39677-39684 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 39804-39811 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T152 40460-40472 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T153 41907-41910 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T154 42571-42578 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T155 43140-43148 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T156 43624-43633 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T157 43818-43823 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T158 44594-44601 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T159 45446-45453 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T160 46022-46029 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 46267-46274 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T162 47626-47633 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T163 47857-47864 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T164 48836-48847 Chemical denotes Pro-Pro-Ala http://purl.obolibrary.org/obo/CHEBI_162578
T165 48874-48885 Chemical denotes Gly-Val-Glu http://purl.obolibrary.org/obo/CHEBI_164159
T166 48886-48889 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T167 49116-49119 Chemical denotes Ile http://purl.obolibrary.org/obo/CHEBI_17191|http://purl.obolibrary.org/obo/CHEBI_30009
T169 50290-50297 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T170 55104-55115 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T171 57561-57569 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T172 59213-59218 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T173 59220-59223 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T175 60584-60591 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T176 60631-60638 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T177 60658-60665 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T178 60706-60713 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T179 63095-63102 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T180 63621-63628 Chemical denotes phorbol http://purl.obolibrary.org/obo/CHEBI_8116
T181 63629-63638 Chemical denotes myristate http://purl.obolibrary.org/obo/CHEBI_30807
T182 63639-63646 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T184 63683-63694 Chemical denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T185 63936-63951 Chemical denotes hydroxamic acid http://purl.obolibrary.org/obo/CHEBI_24650
T186 64912-64921 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T187 65260-65269 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T188 65362-65371 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T189 65578-65587 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T190 66543-66550 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T191 66877-66885 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T192 67141-67179 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine http://purl.obolibrary.org/obo/CHEBI_145998
T193 67488-67495 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T194 68452-68463 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T195 68664-68671 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T196 68878-68885 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 69720-69733 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T198 70189-70196 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T199 70328-70335 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T200 70348-70359 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T201 70376-70383 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T202 70503-70514 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T203 70571-70581 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T204 70723-70730 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T206 70813-70820 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T207 71150-71158 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T208 74208-74221 Chemical denotes macromolecule http://purl.obolibrary.org/obo/CHEBI_33839
T209 75072-75084 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T210 75168-75175 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T20 1057-1065 Species denotes SARS-CoV NCBItxid:694009
T21 1057-1061 Species denotes SARS NCBItxid:694009
T22 1192-1202 Species denotes SARS-CoV-2 NCBItxid:2697049
T23 1192-1196 Species denotes SARS NCBItxid:694009
T24 1244-1252 Species denotes COVID-19 NCBItxid:2697049
T25 1432-1440 Species denotes COVID-19 NCBItxid:2697049
T26 1711-1721 Species denotes SARS-CoV-2 NCBItxid:2697049
T27 1711-1715 Species denotes SARS NCBItxid:694009
T28 2106-2111 Species denotes Human NCBItxid:9606
T29 3569-3574 Species denotes human NCBItxid:9606
T30 3772-3777 Species denotes human NCBItxid:9606
T31 3997-4004 Species denotes insects NCBItxid:6960|NCBItxid:50557
T33 4041-4046 Species denotes human NCBItxid:9606
T34 4466-4471 Species denotes human NCBItxid:9606
T35 6229-6233 Species denotes Rice NCBItxid:4530
T36 8772-8777 Species denotes human NCBItxid:9606
T37 9294-9302 Species denotes COVID-19 NCBItxid:2697049
T38 9337-9347 Species denotes SARS-CoV-2 NCBItxid:2697049
T39 9337-9341 Species denotes SARS NCBItxid:694009
T40 9390-9398 Species denotes COVID-19 NCBItxid:2697049
T41 9512-9517 Species denotes human NCBItxid:9606
T42 11707-11712 Species denotes human NCBItxid:9606
T43 12006-12011 Species denotes human NCBItxid:9606
T44 13592-13600 Species denotes COVID-19 NCBItxid:2697049
T45 13648-13658 Species denotes Sars-CoV-2 NCBItxid:2697049
T46 15477-15487 Species denotes Sars-CoV-2 NCBItxid:2697049
T47 17064-17069 Species denotes human NCBItxid:9606
T48 17375-17381 Species denotes rodent NCBItxid:9989
T49 17674-17679 Species denotes human NCBItxid:9606
T50 17946-17951 Species denotes human NCBItxid:9606
T51 18519-18527 Species denotes primates NCBItxid:9443
T52 18640-18647 Species denotes trachea NCBItxid:988164
T53 18715-18720 Species denotes human NCBItxid:9606
T54 19047-19057 Species denotes SARS-CoV-2 NCBItxid:2697049
T55 19047-19051 Species denotes SARS NCBItxid:694009
T56 19131-19139 Species denotes COVID-19 NCBItxid:2697049
T57 19439-19444 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T59 19446-19449 Species denotes rat NCBItxid:10116|NCBItxid:10114
T61 19451-19454 Species denotes cat NCBItxid:9685
T62 19456-19462 Species denotes ferret NCBItxid:9669
T63 19464-19470 Species denotes monkey NCBItxid:9527|NCBItxid:9479
T65 19475-19480 Species denotes human NCBItxid:9606
T66 19624-19631 Species denotes rodents NCBItxid:9989
T67 20461-20468 Species denotes rodents NCBItxid:9989
T68 20664-20669 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T70 21273-21284 Species denotes hippocampus NCBItxid:72046
T71 21828-21833 Species denotes human NCBItxid:9606
T72 22016-22021 Species denotes human NCBItxid:9606
T73 22234-22240 Species denotes rodent NCBItxid:9989
T74 22378-22383 Species denotes human NCBItxid:9606
T75 22453-22458 Species denotes human NCBItxid:9606
T76 22869-22874 Species denotes human NCBItxid:9606
T77 23708-23713 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T79 26146-26151 Species denotes human NCBItxid:9606
T80 26919-26925 Species denotes sepsis NCBItxid:137507
T81 28689-28695 Species denotes sepsis NCBItxid:137507
T82 28728-28735 Species denotes anthrax NCBItxid:1392
T159 35964-35972 Species denotes MERS CoV NCBItxid:1335626
T83 28771-28785 Species denotes H5N1 avian flu NCBItxid:102793
T84 28790-28794 Species denotes SARS NCBItxid:694009
T85 28839-28843 Species denotes mice NCBItxid:10095|NCBItxid:10088
T87 28935-28941 Species denotes sepsis NCBItxid:137507
T88 30098-30103 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T90 30285-30290 Species denotes human NCBItxid:9606
T91 30661-30684 Species denotes avian influenza viruses NCBItxid:11309
T92 30685-30689 Species denotes H5N1 NCBItxid:102793
T93 30694-30698 Species denotes H7N9 NCBItxid:333278
T94 30816-30824 Species denotes COVID-19 NCBItxid:2697049
T95 30927-30960 Species denotes severe acute respiratory syndrome NCBItxid:694009
T96 30962-30966 Species denotes SARS NCBItxid:694009
T97 31135-31144 Species denotes RNA virus NCBItxid:2559587
T98 31191-31199 Species denotes SARS-CoV NCBItxid:694009
T99 31191-31195 Species denotes SARS NCBItxid:694009
T100 31533-31541 Species denotes SARS-CoV NCBItxid:694009
T101 31533-31537 Species denotes SARS NCBItxid:694009
T102 31571-31577 Species denotes Monkey NCBItxid:9527|NCBItxid:9479
T104 31733-31741 Species denotes SARS-CoV NCBItxid:694009
T105 31733-31737 Species denotes SARS NCBItxid:694009
T106 31753-31757 Species denotes SARS NCBItxid:694009
T107 31887-31892 Species denotes human NCBItxid:9606
T108 32079-32089 Species denotes SARS-CoV-2 NCBItxid:2697049
T109 32079-32083 Species denotes SARS NCBItxid:694009
T110 32123-32131 Species denotes SARS-CoV NCBItxid:694009
T111 32123-32127 Species denotes SARS NCBItxid:694009
T112 32179-32187 Species denotes COVID-19 NCBItxid:2697049
T113 32189-32213 Species denotes COronaVIrus Disease 2019 NCBItxid:2697049
T114 32264-32274 Species denotes SARS-CoV-2 NCBItxid:2697049
T115 32264-32268 Species denotes SARS NCBItxid:694009
T116 32421-32429 Species denotes COVID-19 NCBItxid:2697049
T117 32476-32486 Species denotes SARS-CoV-2 NCBItxid:2697049
T118 32476-32480 Species denotes SARS NCBItxid:694009
T119 33331-33341 Species denotes SARS-CoV-2 NCBItxid:2697049
T120 33331-33335 Species denotes SARS NCBItxid:694009
T121 33415-33429 Species denotes human SARS-CoV NCBItxid:694009
T122 33421-33425 Species denotes SARS NCBItxid:694009
T123 33494-33504 Species denotes SARS-CoV-2 NCBItxid:2697049
T124 33494-33498 Species denotes SARS NCBItxid:694009
T125 33548-33556 Species denotes SARS-CoV NCBItxid:694009
T126 33548-33552 Species denotes SARS NCBItxid:694009
T127 33686-33694 Species denotes SARS-CoV NCBItxid:694009
T128 33686-33690 Species denotes SARS NCBItxid:694009
T129 33700-33710 Species denotes SARS-CoV-2 NCBItxid:2697049
T130 33700-33704 Species denotes SARS NCBItxid:694009
T131 33787-33795 Species denotes SARS-CoV NCBItxid:694009
T132 33787-33791 Species denotes SARS NCBItxid:694009
T133 33799-33809 Species denotes SARS-CoV-2 NCBItxid:2697049
T134 33799-33803 Species denotes SARS NCBItxid:694009
T135 33810-33817 Species denotes viruses NCBItxid:10239
T136 33972-33980 Species denotes SARS-CoV NCBItxid:694009
T137 33972-33976 Species denotes SARS NCBItxid:694009
T138 33985-33995 Species denotes SARS-CoV-2 NCBItxid:2697049
T139 33985-33989 Species denotes SARS NCBItxid:694009
T140 34510-34518 Species denotes SARS-CoV NCBItxid:694009
T141 34510-34514 Species denotes SARS NCBItxid:694009
T142 34534-34544 Species denotes SARS-CoV-2 NCBItxid:2697049
T143 34534-34538 Species denotes SARS NCBItxid:694009
T144 35380-35388 Species denotes SARS-CoV NCBItxid:694009
T145 35380-35384 Species denotes SARS NCBItxid:694009
T146 35393-35403 Species denotes SARS-CoV-2 NCBItxid:2697049
T147 35393-35397 Species denotes SARS NCBItxid:694009
T148 35464-35471 Species denotes viruses NCBItxid:10239
T149 35615-35620 Species denotes human NCBItxid:9606
T150 35622-35625 Species denotes bat NCBItxid:9397
T151 35638-35641 Species denotes pig NCBItxid:9823
T152 35651-35656 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T154 35815-35825 Species denotes SARS-CoV-2 NCBItxid:2697049
T155 35815-35819 Species denotes SARS NCBItxid:694009
T156 35829-35837 Species denotes SARS-CoV NCBItxid:694009
T157 35829-35833 Species denotes SARS NCBItxid:694009
T158 35905-35910 Species denotes human NCBItxid:9606
T160 35977-35986 Species denotes HCoV-229E NCBItxid:11137
T161 36017-36028 Species denotes pseudovirus NCBItxid:186672
T162 36126-36136 Species denotes SARS-CoV-2 NCBItxid:2697049
T163 36126-36130 Species denotes SARS NCBItxid:694009
T164 36187-36194 Species denotes viruses NCBItxid:10239
T165 36343-36351 Species denotes SARS-CoV NCBItxid:694009
T166 36343-36347 Species denotes SARS NCBItxid:694009
T167 36356-36366 Species denotes SARS-CoV-2 NCBItxid:2697049
T168 36356-36360 Species denotes SARS NCBItxid:694009
T169 36427-36435 Species denotes SARS-CoV NCBItxid:694009
T170 36427-36431 Species denotes SARS NCBItxid:694009
T171 36440-36450 Species denotes SARS-CoV-2 NCBItxid:2697049
T172 36440-36444 Species denotes SARS NCBItxid:694009
T173 39688-39698 Species denotes SARS-CoV-2 NCBItxid:2697049
T174 39688-39692 Species denotes SARS NCBItxid:694009
T175 40069-40079 Species denotes SARS-CoV-2 NCBItxid:2697049
T176 40069-40073 Species denotes SARS NCBItxid:694009
T177 40143-40153 Species denotes SARS-CoV-2 NCBItxid:2697049
T178 40143-40147 Species denotes SARS NCBItxid:694009
T179 40177-40185 Species denotes SARS-CoV NCBItxid:694009
T180 40177-40181 Species denotes SARS NCBItxid:694009
T181 40203-40220 Species denotes bat coronaviruses NCBItxid:1508220
T182 40507-40520 Species denotes pseudoviruses NCBItxid:186672
T183 40529-40539 Species denotes SARS-CoV-2 NCBItxid:2697049
T184 40529-40533 Species denotes SARS NCBItxid:694009
T185 40651-40664 Species denotes pseudoviruses NCBItxid:186672
T186 40673-40681 Species denotes SARS-CoV NCBItxid:694009
T187 40673-40677 Species denotes SARS NCBItxid:694009
T188 40707-40717 Species denotes SARS-COV-2 NCBItxid:2697049
T189 40707-40711 Species denotes SARS NCBItxid:694009
T190 41159-41169 Species denotes SARS-CoV-2 NCBItxid:2697049
T191 41159-41163 Species denotes SARS NCBItxid:694009
T192 41212-41220 Species denotes COVID-19 NCBItxid:2697049
T193 41548-41555 Species denotes viruses NCBItxid:10239
T194 41638-41645 Species denotes viruses NCBItxid:10239
T195 41697-41704 Species denotes viruses NCBItxid:10239
T196 41923-41930 Species denotes viruses NCBItxid:10239
T197 42247-42254 Species denotes viruses NCBItxid:10239
T198 42335-42345 Species denotes SARS-CoV-2 NCBItxid:2697049
T199 42335-42339 Species denotes SARS NCBItxid:694009
T200 42379-42389 Species denotes SARS-CoV-2 NCBItxid:2697049
T201 42379-42383 Species denotes SARS NCBItxid:694009
T202 42394-42402 Species denotes SARS-CoV NCBItxid:694009
T203 42394-42398 Species denotes SARS NCBItxid:694009
T204 42470-42480 Species denotes SARS-CoV-2 NCBItxid:2697049
T205 42470-42474 Species denotes SARS NCBItxid:694009
T206 42511-42519 Species denotes SARS-CoV NCBItxid:694009
T207 42511-42515 Species denotes SARS NCBItxid:694009
T208 42521-42529 Species denotes SARS-CoV NCBItxid:694009
T209 42521-42525 Species denotes SARS NCBItxid:694009
T210 42647-42657 Species denotes SARS-CoV-2 NCBItxid:2697049
T211 42647-42651 Species denotes SARS NCBItxid:694009
T212 42704-42712 Species denotes SARS-CoV NCBItxid:694009
T213 42704-42708 Species denotes SARS NCBItxid:694009
T214 42820-42830 Species denotes SARS-CoV-2 NCBItxid:2697049
T215 42820-42824 Species denotes SARS NCBItxid:694009
T216 42876-42886 Species denotes SARS-CoV-2 NCBItxid:2697049
T217 42876-42880 Species denotes SARS NCBItxid:694009
T218 43057-43061 Species denotes MERS NCBItxid:1335626
T219 43207-43217 Species denotes SARS-CoV-2 NCBItxid:2697049
T220 43207-43211 Species denotes SARS NCBItxid:694009
T221 43314-43324 Species denotes SARS-CoV-2 NCBItxid:2697049
T222 43314-43318 Species denotes SARS NCBItxid:694009
T223 43744-43754 Species denotes SARS-COV-2 NCBItxid:2697049
T224 43744-43748 Species denotes SARS NCBItxid:694009
T225 43759-43767 Species denotes SARS-CoV NCBItxid:694009
T226 43759-43763 Species denotes SARS NCBItxid:694009
T227 43977-43987 Species denotes SARS-CoV-2 NCBItxid:2697049
T228 43977-43981 Species denotes SARS NCBItxid:694009
T229 44131-44141 Species denotes SARS-CoV-2 NCBItxid:2697049
T230 44131-44135 Species denotes SARS NCBItxid:694009
T231 44397-44407 Species denotes SARS-CoV-2 NCBItxid:2697049
T232 44397-44401 Species denotes SARS NCBItxid:694009
T233 44494-44504 Species denotes SARS-CoV-2 NCBItxid:2697049
T234 44494-44498 Species denotes SARS NCBItxid:694009
T235 44965-44975 Species denotes SARS-CoV-2 NCBItxid:2697049
T236 44965-44969 Species denotes SARS NCBItxid:694009
T237 45034-45042 Species denotes SARS-CoV NCBItxid:694009
T238 45034-45038 Species denotes SARS NCBItxid:694009
T239 45214-45224 Species denotes SARS-CoV-2 NCBItxid:2697049
T240 45214-45218 Species denotes SARS NCBItxid:694009
T241 45262-45272 Species denotes SARS-CoV-2 NCBItxid:2697049
T242 45262-45266 Species denotes SARS NCBItxid:694009
T243 45296-45304 Species denotes SARS-CoV NCBItxid:694009
T244 45296-45300 Species denotes SARS NCBItxid:694009
T245 45433-45443 Species denotes SARS-CoV-2 NCBItxid:2697049
T246 45433-45437 Species denotes SARS NCBItxid:694009
T247 45493-45497 Species denotes SARS NCBItxid:694009
T248 45560-45570 Species denotes SARS-CoV-2 NCBItxid:2697049
T249 45560-45564 Species denotes SARS NCBItxid:694009
T250 45629-45637 Species denotes SARS-CoV NCBItxid:694009
T251 45629-45633 Species denotes SARS NCBItxid:694009
T252 45807-45817 Species denotes SARS-CoV-2 NCBItxid:2697049
T253 45807-45811 Species denotes SARS NCBItxid:694009
T254 45822-45830 Species denotes SARS-CoV NCBItxid:694009
T255 45822-45826 Species denotes SARS NCBItxid:694009
T256 45866-45876 Species denotes SARS-CoV-2 NCBItxid:2697049
T257 45866-45870 Species denotes SARS NCBItxid:694009
T258 46179-46189 Species denotes SARS-CoV-2 NCBItxid:2697049
T259 46179-46183 Species denotes SARS NCBItxid:694009
T260 46246-46256 Species denotes SARS-CoV-2 NCBItxid:2697049
T261 46246-46250 Species denotes SARS NCBItxid:694009
T262 46344-46350 Species denotes SARS-2 NCBItxid:2697049
T263 46344-46348 Species denotes SARS NCBItxid:694009
T264 46384-46390 Species denotes SARS-2 NCBItxid:2697049
T265 46384-46388 Species denotes SARS NCBItxid:694009
T266 46422-46428 Species denotes SARS-2 NCBItxid:2697049
T267 46422-46426 Species denotes SARS NCBItxid:694009
T268 46472-46478 Species denotes SARS-2 NCBItxid:2697049
T269 46472-46476 Species denotes SARS NCBItxid:694009
T270 46525-46531 Species denotes SARS-2 NCBItxid:2697049
T271 46525-46529 Species denotes SARS NCBItxid:694009
T272 46575-46581 Species denotes SARS-2 NCBItxid:2697049
T273 46575-46579 Species denotes SARS NCBItxid:694009
T274 46623-46629 Species denotes SARS-2 NCBItxid:2697049
T275 46623-46627 Species denotes SARS NCBItxid:694009
T276 46690-46696 Species denotes SARS-2 NCBItxid:2697049
T277 46690-46694 Species denotes SARS NCBItxid:694009
T278 46933-46941 Species denotes SARS-CoV NCBItxid:694009
T279 46933-46937 Species denotes SARS NCBItxid:694009
T280 47057-47065 Species denotes SARS-CoV NCBItxid:694009
T281 47057-47061 Species denotes SARS NCBItxid:694009
T282 47236-47246 Species denotes SARS-CoV-2 NCBItxid:2697049
T283 47236-47240 Species denotes SARS NCBItxid:694009
T284 47312-47322 Species denotes SARS-CoV-2 NCBItxid:2697049
T285 47312-47316 Species denotes SARS NCBItxid:694009
T286 47986-47994 Species denotes SARS-CoV NCBItxid:694009
T287 47986-47990 Species denotes SARS NCBItxid:694009
T288 48008-48018 Species denotes SARS-CoV-2 NCBItxid:2697049
T289 48008-48012 Species denotes SARS NCBItxid:694009
T290 48083-48093 Species denotes SARS-CoV-2 NCBItxid:2697049
T291 48083-48087 Species denotes SARS NCBItxid:694009
T292 48153-48161 Species denotes SARS-CoV NCBItxid:694009
T293 48153-48157 Species denotes SARS NCBItxid:694009
T294 48754-48764 Species denotes SARS-CoV-2 NCBItxid:2697049
T295 48754-48758 Species denotes SARS NCBItxid:694009
T296 48769-48777 Species denotes SARS-CoV NCBItxid:694009
T297 48769-48773 Species denotes SARS NCBItxid:694009
T298 48806-48814 Species denotes SARS-CoV NCBItxid:694009
T299 48806-48810 Species denotes SARS NCBItxid:694009
T300 48893-48903 Species denotes SARS-CoV-2 NCBItxid:2697049
T301 48893-48897 Species denotes SARS NCBItxid:694009
T302 49085-49095 Species denotes SARS-CoV-2 NCBItxid:2697049
T303 49085-49089 Species denotes SARS NCBItxid:694009
T304 49123-49127 Species denotes SARS NCBItxid:694009
T305 49462-49472 Species denotes SARS-CoV-2 NCBItxid:2697049
T306 49462-49466 Species denotes SARS NCBItxid:694009
T307 49489-49493 Species denotes SARS NCBItxid:694009
T308 49598-49608 Species denotes SARS-CoV-2 NCBItxid:2697049
T309 49598-49602 Species denotes SARS NCBItxid:694009
T310 50179-50186 Species denotes mammals NCBItxid:40674
T311 50211-50215 Species denotes cats NCBItxid:9685
T312 50220-50224 Species denotes dogs NCBItxid:9615
T313 50277-50287 Species denotes SARS-CoV-2 NCBItxid:2697049
T314 50277-50281 Species denotes SARS NCBItxid:694009
T315 50312-50320 Species denotes COVID-19 NCBItxid:2697049
T316 50460-50465 Species denotes human NCBItxid:9606
T317 50471-50480 Species denotes hCoV-NL63 NCBItxid:277944
T318 50610-50614 Species denotes SARS NCBItxid:694009
T319 50627-50637 Species denotes SARS-CoV-2 NCBItxid:2697049
T320 50627-50631 Species denotes SARS NCBItxid:694009
T321 50683-50692 Species denotes hCoV-NL63 NCBItxid:277944
T322 50715-50723 Species denotes SARS-CoV NCBItxid:694009
T323 50715-50719 Species denotes SARS NCBItxid:694009
T324 50866-50876 Species denotes SARS-CoV-2 NCBItxid:2697049
T325 50866-50870 Species denotes SARS NCBItxid:694009
T326 51068-51074 Species denotes humans NCBItxid:9605
T327 51130-51133 Species denotes bat NCBItxid:9397
T328 51183-51186 Species denotes bat NCBItxid:9397
T329 51301-51311 Species denotes SARS-CoV-2 NCBItxid:2697049
T330 51301-51305 Species denotes SARS NCBItxid:694009
T331 51368-51371 Species denotes bat NCBItxid:9397
T332 51490-51498 Species denotes COVID-19 NCBItxid:2697049
T333 52467-52475 Species denotes COVID-19 NCBItxid:2697049
T334 53309-53317 Species denotes COVID-19 NCBItxid:2697049
T335 53404-53414 Species denotes SARS-CoV-2 NCBItxid:2697049
T336 53404-53408 Species denotes SARS NCBItxid:694009
T337 54019-54027 Species denotes SARS-CoV NCBItxid:694009
T338 54019-54023 Species denotes SARS NCBItxid:694009
T339 54111-54121 Species denotes SARS-CoV-2 NCBItxid:2697049
T340 54111-54115 Species denotes SARS NCBItxid:694009
T341 54207-54217 Species denotes SARS-CoV-2 NCBItxid:2697049
T342 54207-54211 Species denotes SARS NCBItxid:694009
T343 55702-55712 Species denotes SARS-CoV-2 NCBItxid:2697049
T344 55702-55706 Species denotes SARS NCBItxid:694009
T345 55946-55956 Species denotes SARS-CoV-2 NCBItxid:2697049
T346 55946-55950 Species denotes SARS NCBItxid:694009
T347 56616-56624 Species denotes COVID-19 NCBItxid:2697049
T348 57017-57025 Species denotes COVID-19 NCBItxid:2697049
T349 57135-57143 Species denotes COVID-19 NCBItxid:2697049
T350 57358-57368 Species denotes SARS-CoV-2 NCBItxid:2697049
T351 57358-57362 Species denotes SARS NCBItxid:694009
T352 57382-57387 Species denotes human NCBItxid:9606
T353 57516-57521 Species denotes human NCBItxid:9606
T354 57668-57676 Species denotes COVID-19 NCBItxid:2697049
T355 57777-57787 Species denotes SARS-CoV-2 NCBItxid:2697049
T356 57777-57781 Species denotes SARS NCBItxid:694009
T357 57838-57845 Species denotes COVID19 NCBItxid:2697049
T358 58179-58187 Species denotes COVID-19 NCBItxid:2697049
T359 58642-58650 Species denotes COVID-19 NCBItxid:2697049
T360 59022-59030 Species denotes COVID-19 NCBItxid:2697049
T361 61089-61099 Species denotes SARS-CoV-2 NCBItxid:2697049
T362 61089-61093 Species denotes SARS NCBItxid:694009
T363 61108-61118 Species denotes SARS-CoV-2 NCBItxid:2697049
T364 61108-61112 Species denotes SARS NCBItxid:694009
T365 61326-61334 Species denotes COVID-19 NCBItxid:2697049
T366 61531-61539 Species denotes COVID-19 NCBItxid:2697049
T367 61723-61733 Species denotes SARS-CoV-2 NCBItxid:2697049
T368 61723-61727 Species denotes SARS NCBItxid:694009
T369 63532-63537 Species denotes human NCBItxid:9606
T370 63581-63586 Species denotes human NCBItxid:9606
T371 64718-64728 Species denotes SARS-CoV-2 NCBItxid:2697049
T372 64718-64722 Species denotes SARS NCBItxid:694009
T373 64886-64896 Species denotes SARS-CoV-2 NCBItxid:2697049
T374 64886-64890 Species denotes SARS NCBItxid:694009
T375 65089-65097 Species denotes COVID-19 NCBItxid:2697049
T376 65274-65284 Species denotes SARS-CoV-2 NCBItxid:2697049
T377 65274-65278 Species denotes SARS NCBItxid:694009
T378 65317-65327 Species denotes SARS-CoV-2 NCBItxid:2697049
T379 65317-65321 Species denotes SARS NCBItxid:694009
T380 65690-65700 Species denotes SARS-CoV-2 NCBItxid:2697049
T381 65690-65694 Species denotes SARS NCBItxid:694009
T382 65889-65897 Species denotes COVID-19 NCBItxid:2697049
T383 65949-65959 Species denotes SARS-CoV-2 NCBItxid:2697049
T384 65949-65953 Species denotes SARS NCBItxid:694009
T385 66428-66433 Species denotes human NCBItxid:9606
T386 67054-67062 Species denotes SARS-CoV NCBItxid:694009
T387 67054-67058 Species denotes SARS NCBItxid:694009
T388 67276-67284 Species denotes SARS-CoV NCBItxid:694009
T389 67276-67280 Species denotes SARS NCBItxid:694009
T390 67579-67583 Species denotes SARS NCBItxid:694009
T391 67734-67750 Species denotes SARS coronavirus NCBItxid:694009
T392 67734-67738 Species denotes SARS NCBItxid:694009
T393 68129-68139 Species denotes SARS-CoV-2 NCBItxid:2697049
T394 68129-68133 Species denotes SARS NCBItxid:694009
T395 68446-68451 Species denotes human NCBItxid:9606
T396 68510-68518 Species denotes COVID-19 NCBItxid:2697049
T397 68556-68561 Species denotes human NCBItxid:9606
T398 68816-68824 Species denotes COVID-19 NCBItxid:2697049
T399 69196-69206 Species denotes SARS-CoV-2 NCBItxid:2697049
T400 69196-69200 Species denotes SARS NCBItxid:694009
T401 69232-69237 Species denotes human NCBItxid:9606
T402 69265-69270 Species denotes human NCBItxid:9606
T403 69426-69436 Species denotes SARS-CoV-2 NCBItxid:2697049
T404 69426-69430 Species denotes SARS NCBItxid:694009
T405 69533-69543 Species denotes SARS-CoV-2 NCBItxid:2697049
T406 69533-69537 Species denotes SARS NCBItxid:694009
T407 70605-70619 Species denotes gut microbiome NCBItxid:749906
T408 71691-71696 Species denotes human NCBItxid:9606
T409 71711-71715 Species denotes mice NCBItxid:10095|NCBItxid:10088
T411 72173-72181 Species denotes COVID-19 NCBItxid:2697049
T412 74771-74779 Species denotes COVID-19 NCBItxid:2697049
T413 74878-74882 Species denotes SARS NCBItxid:694009
T414 74891-74900 Species denotes SARS-Cov2 NCBItxid:2697049
T415 74891-74895 Species denotes SARS NCBItxid:694009
T416 74901-74908 Species denotes viruses NCBItxid:10239
T417 75328-75336 Species denotes COVID-19 NCBItxid:2697049
T418 75573-75581 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T19 0-12 Sentence denotes Introduction
T20 13-191 Sentence denotes Angiotensin-converting enzyme (ACE) has an important role in the metabolism of several peptides and proteins, including chemical messengers, such as angiotensin I and bradykinin.
T21 192-465 Sentence denotes The importance assumed by research focused on ACE biochemistry, physiology and pharmacology is closely linked to the clinical effectiveness showed by ACE inhibitors in the treatment of cardiovascular disease, particularly arterial hypertension and congestive heart failure.
T22 466-546 Sentence denotes At present, ACE inhibitors are among the most widely prescribed drugs worldwide.
T23 547-618 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 619-718 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 719-785 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 786-985 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 986-1158 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 1159-1373 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.
T29 1374-1615 Sentence denotes Hypertension has been suggested to have a major impact on COVID-19 susceptibility and prognosis, therefore the elusive link between hypertension, anti-hypertensive drugs, and ACE2 expression has soon become the object of a major controversy.
T30 1616-1795 Sentence denotes On the other hand, treatments able to interfere with ACE2 expression, or ACE2 availability for SARS-CoV-2 binding, have been identified as a novel goal of pharmaceutical research.
T31 1796-1903 Sentence denotes The purpose of the present review is to summarize the available knowledge on ACE2 biochemistry and biology.
T32 1904-2074 Sentence denotes We have also tried to point out some crucial open questions, which should be addressed to provide a better background for future experimental and clinical investigations.
T33 2076-2105 Sentence denotes ACE System and ACE2 Discovery
T34 2106-2329 Sentence denotes Human Angiotensin-converting enzyme (ACE) belongs to the M2 gluzincin family of metalloproteinases and (Ehlers and Riordan, 1989; Masuyer et al., 2014) exists in two forms, namely somatic ACE (sACE) and germinal ACE (tACE).
T35 2330-2552 Sentence denotes Both are derived from the same gene, controlled by alternative promotors. sACE is an integral membrane protein, which can be also cleaved by ACE secretases to produce a circulating form of the enzyme (Natesh et al., 2003).
T36 2553-2789 Sentence denotes sACE, hereafter referred to simply as ACE, has been extensively studied, because of its crucial role in the homeostasis of renin-angiotensin-aldosterone (RAAS) system and in cardiovascular diseases (Takimoto-Ohnishi and Murakami, 2019).
T37 2790-3023 Sentence denotes The two extracellular domains N and C domains of ACE (Wei et al., 1991; Jaspard et al., 1993; Natesh et al., 2003; Riordan, 2003) can both hydrolase two crucial peptides, namely angiotensin I and bradykinin, with the same efficiency.
T38 3024-3244 Sentence denotes Indeed, ACE carries out the cleavage of two amino acids (dipeptidase action) from the C-terminal part of angiotensin I to generate angiotensin II, which exerts a potent vasopressor, proliferative, and profibrotic effect.
T39 3245-3356 Sentence denotes Moreover, ACE mediates the cleavage and inactivation of bradykinin, which is a vasodilator hypotensive peptide.
T40 3357-3484 Sentence denotes The pivotal role of ACE in the RAAS system allows a refined blood pressure control and salt homeostasis (Sayer and Bhat, 2014).
T41 3485-3673 Sentence denotes Following the ACE discovery in mid-1950s, despite intense research in the field, no human homologs of the enzyme have been found for more than 50 years (Isaac et al., 1998; Riordan, 2003).
T42 3674-3825 Sentence denotes It was only in 2000 that two independent research groups identified, almost simultaneously, a new human ACE-like enzyme, with two different approaches.
T43 3826-4005 Sentence denotes Tipnis et al. (2000) searched for new metalloproteases in an expressed sequence tag (EST) database, finding an ACE homolog (ACEH) with a single domain, similar to that of insects.
T44 4006-4069 Sentence denotes Subsequently they cloned it from a human lymphoma cDNA library.
T45 4070-4258 Sentence denotes Interestingly ACEH showed high homology (40% identity and 60% similarity) with ACE, particularly around the HEXXH sequence and highly conserved glutamate residue, involved in zinc binding.
T46 4259-4351 Sentence denotes Moreover, they demonstrated the presence of seven glycosylation sites (Tipnis et al., 2000).
T47 4352-4672 Sentence denotes In the same year, Donoghue et al. (2000b) were searching for new genes involved in heart failure and identified a human cDNA ACE homolog, named ACE2, among 19,000 5’end sequences by RACE (rapid amplification of cDNA ends) in the heart ventricle cDNA library, obtained from a woman with idiopathic dilated cardiomyopathy.
T48 4673-4775 Sentence denotes ACE2 showed a transmembrane domain, a zinc catalytic domain 42% identical to ACE and a signal peptide.
T49 4776-4833 Sentence denotes Like ACE, ACE2 seemed to be an ectoenzyme type I protein.
T50 4834-5002 Sentence denotes The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b).
T51 5003-5142 Sentence denotes In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.
T52 5144-5149 Sentence denotes ACE2:
T53 5150-5206 Sentence denotes Structure, Expression, Tissue Distribution, and Function
T54 5208-5225 Sentence denotes Structure of ACE2
T55 5226-5347 Sentence denotes ACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17.
T56 5348-5405 Sentence denotes The 18 exons of ACE2 are remarkably similar to ACE exons.
T57 5406-5695 Sentence denotes The ACE2 gene depicts a large polymorphism and several novel polymorphisms of ACE2, with specific geographical distribution, have been described and associated with susceptibility to hypertension and cardiovascular disease (Burrell et al., 2013; Patel et al., 2014; Pinheiro et al., 2019).
T58 5696-5816 Sentence denotes The ACE2 gene codifies for a typical zinc-metallopeptidase of 805 amino acids (120 kDa), with a unique catalytic domain.
T59 5817-5927 Sentence denotes Despite the high resemblance of ACE and ACE2, considerable differences exist in their substrates and products.
T60 5928-6017 Sentence denotes While ACE acts as dipeptidase, ACE2 removes only a single amino acid from its substrates.
T61 6018-6269 Sentence denotes Therefore, ACE2 is not active in transforming angiotensin I to angiotensin II and in inactivating bradykinin; moreover, ACE2 is insensitive to ACE inhibitors, like lisinopril and captopril (Tipnis et al., 2000; Rice et al., 2004; Turner et al., 2004).
T62 6270-6367 Sentence denotes These differences depend on variances in the three-dimensional structure (3D) of the two enzymes.
T63 6368-6476 Sentence denotes Comparative homology modeling and crystallography contributed to shed light on ACE2 3D structure (Figure 1).
T64 6477-6629 Sentence denotes Prabakaran et al. (2004) clarified the major characteristic of ACE2, which is a deep channel on the summit of the protein, hosting the catalytic domain.
T65 6630-6778 Sentence denotes Specific loops, like the long loop N210-Q221 that is exclusive of ACE2, α helices and a portion of β-sheet are located around the catalytic channel.
T66 6779-6939 Sentence denotes The negative charge of the channel and the presence of distinct hydrophobic regions contribute to the specificity of the binding site (Prabakaran et al., 2004).
T67 6940-7202 Sentence denotes The determination of the crystal structure of the extracellular domain to 2.2-3-A resolution from Towler et al. (2004) and the model from Guy et al. (2003) showed that the catalytic domain of ACE and ACE2 are very conserved and have similar mechanisms of action.
T68 7203-7474 Sentence denotes The main difference stems from the smaller ACE2 pocket, thereby lodging only a single amino acid: the crucial substitution of the Gln281 in ACE binding pocket with Arg273 in ACE2 is likely to be responsible for the steric conflict (Guy et al., 2003; Towler et al., 2004).
T69 7475-7711 Sentence denotes Another surprise of the ACE2 structure was its C-terminal domain, which—differently from ACE—revealed high homology with collectrin, a renal protein, which is involved in amino acids trafficking through the membrane (Yang et al., 2017).
T70 7712-7748 Sentence denotes FIGURE 1 Crystal structure of ACE2.
T71 7749-7864 Sentence denotes The peptidase domain (PD) is in green, whereas the collectrin homology domain is enclosed in the light cyan square.
T72 7865-8010 Sentence denotes The active zinc ion is showed enclosed in a red circle, whereas the glycosylation moieties are showed as cyan cubes and denoted by dashed arrows.
T73 8011-8104 Sentence denotes The structures have been drawn from PDB 1R42 (Towler et al., 2004) by Mol on the PDB website.
T74 8106-8186 Sentence denotes Transcriptional, Post-transcriptional, and Post-translational Regulation of ACE2
T75 8187-8470 Sentence denotes The location of the ACE2 gene on the X chromosome questions whether one of the two ACE2 is silenced in females, to balance female/male expression dosage (X chromosome inactivation or XCI), or otherwise belongs to the class of “escape genes” which are transcribed on both chromosomes.
T76 8471-8659 Sentence denotes Interestingly, a wide survey of XCI in several individuals and tissues showed that ACE2 is a heterogeneous escape gene, because it has a tissue-dependent sex bias (Tukiainen et al., 2017).
T77 8660-8812 Sentence denotes A growing number of recent findings point to an important role of epigenetic mechanisms associated with several human diseases (Surguchov et al., 2017).
T78 8813-8987 Sentence denotes In this context, several authors highlighted the regulatory role of 17β-estradiol (E2), a primary female sex steroid, in the expression of ACE2 in a tissue-dependent fashion.
T79 8988-9136 Sentence denotes Liu et al. (2010) and Stelzig et al. (2020) found out that E2 downregulates ACE2 in kidney and differentiated airway epithelial cells, respectively.
T80 9137-9419 Sentence denotes The latter result is particularly important, as the male-bias of ACE2 expression in the lung could account for the alleged higher susceptibility of males to COVID-19 symptoms following ACE2-dependent SARS-CoV-2 infection (section Links Between ACE2 and COVID-19) (Jin et al., 2020).
T81 9420-9592 Sentence denotes Yet, Bukowska et al. (2017) observed that E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein.
T82 9593-9804 Sentence denotes This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to myocardial stress and contributes to antiarhythmic effects.
T83 9805-9951 Sentence denotes The upregulation of ACE2 (and downregulation of ACE) was clearly linked to binding of E2 to Estrogen Receptor alpha (ERα) (Bukowska et al., 2017).
T84 9952-10192 Sentence denotes The E2-ERα complex might migrate to the nucleus to bind to estrogen response elements, although the actual mechanism is still obscure and should likely involve other co-factors to take into account the observed tissue bias of E2 regulation.
T85 10193-10442 Sentence denotes Nonetheless, it was demonstrated that the Estrogen Related Receptor alpha (ERRα), which likewise ERα recognizes the estrogen response element in target genes, binds to ACE2 promoter to repress transcription (Tremblay et al., 2010; Lee et al., 2012).
T86 10443-10545 Sentence denotes Hopefully, future studies will shed more light on the intriguing role of estrogens in ACE2 regulation.
T87 10546-10708 Sentence denotes A recent analysis of public genomic and transcriptomic data outlined the role of histone methylation, a classical epigenetic mark, to regulate ACE2 transcription.
T88 10709-10870 Sentence denotes Indeed, Li Y. et al. (2020) showed that transcription of ACE2 was significantly upregulated when the histone mutant H3K27M was overexpressed to inhibit H3K27me3.
T89 10871-10953 Sentence denotes Conversely, overexpression of mutant H3K4/9/36M did not change ACE2 transcription.
T90 10954-11109 Sentence denotes Trimethylation of K27 on H3 is catalyzed by the polycomb groups (PcG), a group of conserved transcriptional gene repressors (Schuettengruber et al., 2017).
T91 11110-11172 Sentence denotes PcG proteins assemble into two major complexes: PRC1 and PRC2.
T92 11173-11297 Sentence denotes The simplest model of PcG activity involves trimethylation of H3 by PRC2 at target gene promoters (Blackledge et al., 2015).
T93 11298-11546 Sentence denotes These epigenetic marks recruit PRC1 on DNA, which in turn acts as E3-ligase and ubiquitinates nearby H2A histones (Storti et al., 2019), triggering silencing of gene transcription by local and reversible compaction of chromatin (Illingworth, 2019).
T94 11547-11612 Sentence denotes The catalytic subunit of PRC2 is constituted by the EZH2 protein.
T95 11613-11780 Sentence denotes In agreement with the inverse correlation between ACE2 level and H3K27me3, ACE2 expression in human ESCs was upregulated following EZH2 knock-out (Li Y. et al., 2020).
T96 11781-11844 Sentence denotes On the other side, recovery of EZH2 restored basal ACE2 levels.
T97 11845-12038 Sentence denotes Chromatin immunoprecipitation sequencing (ChIP-seq) showed that EZH2 depletion induced H3K27me3 decrease, with concomitant H3K27ac increase, at ACE2 promoter in human ESCs (Li Y. et al., 2020).
T98 12039-12325 Sentence denotes The role of H3 methylation and acetylation in the epigenetic regulation of ACE2 was also hypothesized by Pinto et al., who demonstrated that co-morbidities such as hypertension, diabetes, and chronic obstructive lung disease increase ACE2 transcription in the lung (Pinto et al., 2020).
T99 12326-12407 Sentence denotes Histone methylation does not appear to exhaust the epigenetic regulation of ACE2.
T100 12408-12556 Sentence denotes Notably, the NAD+-dependent deacetylase SIRT1 binds to ACE2 promoter favoring its transcription during cellular energy stress (Clarke et al., 2014).
T101 12557-12637 Sentence denotes Two recent unrefereed preprints highlighted other epigenetic mechanisms at play.
T102 12638-12842 Sentence denotes Corley et al.1 pointed out that DNA methylation across three CpG islands in the ACE2 promoter was lower in lung epithelial cells compared to other cell types, suggesting high transcription in lung tissue.
T103 12843-13045 Sentence denotes These findings are in excellent agreement with the reported inverse correlation between ACE2 transcription and promoter methylation in tumors, which will be discussed in section ACE2 and Other Diseases.
T104 13046-13228 Sentence denotes This correlation is also supported by the observation that in children ACE2 is normally hypermethylated and poorly expressed either in the lung and in other organs (Pruimboom, 2020).
T105 13229-13450 Sentence denotes Glinsky (2020) addressed the epigenetic role of Vitamin D on ACE2 expression, showing by gene set enrichment analysis that the Vitamin D receptor (VDR) should be involved in a set of regulatory pathways conveying on ACE2.
T106 13451-13660 Sentence denotes More specifically, VDR activation would downregulate ACE2, thus affording a potential reason for the alleged beneficial role of Vitamin D in COVID-19 (section ACE2 and the Inflammatory Response to Sars-CoV-2).
T107 13661-13780 Sentence denotes Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins.
T108 13781-14076 Sentence denotes Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart.
T109 14077-14121 Sentence denotes Further regulation occurs at the mRNA level.
T110 14122-14247 Sentence denotes From putative microRNA-binding sites identified in vitro, Lambert et al. (2014) demonstrated that miR-421 downregulates ACE2.
T111 14248-14395 Sentence denotes According to the hypothesized mechanism, miR-421 modulates ACE2 expression by hampering translation rather than by degradation of mRNA transcripts.
T112 14396-14611 Sentence denotes Beside undergoing post-translational modifications by glycosylation and phosphorylation, ACE2 is also post-translationally regulated by shedding from cell membrane through the action of the metalloproteinase ADAM17.
T113 14612-14782 Sentence denotes The proteolysis of ACE2 releases a soluble, enzymatically active form which corresponds to the ACE2 ectodomain (Jia et al., 2009; Xiao et al., 2014; Conrad et al., 2016).
T114 14783-14900 Sentence denotes The function, if any, of soluble ACE2 is still obscure, but the shedding mechanism is under strict molecular control.
T115 14901-15063 Sentence denotes Lambert et al. (2008) highlighted that calmodulin associates with ACE2 to prevent its shedding, while calmodulin inhibitors increase the cellular release of ACE2.
T116 15064-15113 Sentence denotes Patel identified a positive feedback in the RAAS:
T117 15114-15224 Sentence denotes Ang II activates ADAM17, thereby increasing the release of ACE2, its negative regulator (Patel et al., 2016b).
T118 15225-15356 Sentence denotes It is worth noting that high levels of plasma-soluble ACE2 have been associated with myocardial dysfunction (Epelman et al., 2009).
T119 15357-15488 Sentence denotes The potential pathophysiological role of ADAM17 is further discussed in paragraph ACE2 and the Inflammatory Response to Sars-CoV-2.
T120 15489-15609 Sentence denotes Figure 2 summarizes the known transcriptional, post-transcriptional, and post translational regulation pathways of ACE2.
T121 15610-15711 Sentence denotes FIGURE 2 Regulation pathways of transcription, translation, and post-translational shedding of ACE2.
T122 15712-15744 Sentence denotes Red text: non-molecular factors.
T123 15745-15775 Sentence denotes Black text: molecular factors.
T124 15777-15804 Sentence denotes Tissue Distribution of ACE2
T125 15805-15945 Sentence denotes Detectable quantities of ACE2 protein have been found almost ubiquitously in tissues across mammalian species, using immunostaining methods.
T126 15946-16163 Sentence denotes ACE2 is predominantly located in the cardiovascular system and kidney, where it probably plays a role in the maintenance of hydro electrolyte homeostasis (section “Mechanism of Viral Entry Mediated by the S Protein”).
T127 16164-16382 Sentence denotes In fact, ACE2 is pervasively expressed throughout the vasculature, at the level of the arteries and veins, mainly in smooth muscle cells of the media and in the endothelium (Hamming et al., 2004; Burrell et al., 2005).
T128 16383-16473 Sentence denotes Such signal from vessels also delivers part of the expression detected in specific organs.
T129 16474-16812 Sentence denotes Indeed, ACE2 is evident in: coronary vessels and myocardial capillaries (Wiener et al., 2007; Garabelli et al., 2008); lung microvascular endothelial cells (Wiener et al., 2007; Chen et al., 2013); kidney interlobular arteries (Lely et al., 2004); endothelial and smooth muscle cells in the brain (Hamming et al., 2004; Kar et al., 2010).
T130 16813-16990 Sentence denotes Notably, the mesangium and glomerular endothelium in the kidney, and the endothelial lining of the sinusoids in the liver are allegedly negative for ACE2 (Hamming et al., 2004).
T131 16991-17178 Sentence denotes On the contrary, ACE2 is virtually absent from the lymphatic system, and human hemato-lymphoid organs (i.e., spleen, lymph nodes, and bone marrow) (Hamming et al., 2004; Li et al., 2007).
T132 17179-17326 Sentence denotes In blood cells, it has been observed in platelets and macrophages, but not in B and T lymphocytes (Hamming et al., 2004; Fraga-Silva et al., 2011).
T133 17327-17670 Sentence denotes Expression of ACE2 was originally identified in rodent heart (Donoghue et al., 2000a), where it was observed to occur in both atrium an ventricle (Gembardt et al., 2005), and, cellularly, in cardiomyocytes and in specialized cells of the sinoatrial node (Burrell et al., 2005; Garabelli et al., 2008; Ferreira et al., 2011; Wang et al., 2017).
T134 17671-17863 Sentence denotes In human heart, ACE2 has been found in the stromal area in spongiosa layer in aortic valves (Peltonen et al., 2011), where it is expressed in myofibroblasts and fibroblasts (Guy et al., 2008).
T135 17864-18151 Sentence denotes High levels of ACE2 protein expression have been detected in mammalian, including human, kidney (Gembardt et al., 2005; Koka et al., 2008; Reich et al., 2008; Giani et al., 2012; Mitani et al., 2014; Grobe et al., 2015; Shi et al., 2015; Larouche-Lebel et al., 2019; Alawi et al., 2020).
T136 18152-18490 Sentence denotes Strong signals were reported in the brush border of the proximal tubular cells, whereas weak to moderate signals could be found in the glomeruli, Henle’s loop, distal tubules, and collecting duct (Hamming et al., 2004; Lely et al., 2004; Kamilic et al., 2010; Giani et al., 2012; Bae et al., 2015; Cao et al., 2017; Errarte et al., 2017).
T137 18491-18685 Sentence denotes In the respiratory tract of primates, positive labeling for ACE2 has been reported at multiple sites, from the nasal and oral mucosa, to the larynx, trachea, bronchi and lung (Liu et al., 2011).
T138 18686-18971 Sentence denotes Whether ACE2 is expressed in human nasal and oral epithelium remains unclear, as contradictory results have been reported by studies using immunohistochemistry (Hamming et al., 2004; Bertram et al., 2012), in face of positive single-cell RNA sequencing findings (Sungnak et al., 2020).
T139 18972-19142 Sentence denotes This point is of great interest to understand the role of those tissues in SARS-CoV-2 initial infection, spread and clearance (section “Links Between ACE2 and COVID-19”).
T140 19143-19300 Sentence denotes In the upper respiratory tract ACE2 is expressed in the epithelial lining and lamina propria, in some muscle cells and in the salivary gland duct epithelium.
T141 19301-19595 Sentence denotes In the lung, an intense signal for ACE2 protein has been consistently observed in type I and II pneumocytes in several species, including mouse, rat, cat, ferret, monkey and human (Wiener et al., 2007; van den Brand et al., 2008; Liu et al., 2011; Wong et al., 2012; Chen et al., 2013; Zhang B.
T142 19596-19613 Sentence denotes N. et al., 2019).
T143 19614-19778 Sentence denotes Data from rodents suggest an age- and gender-dependent pattern of expression, with a more rapid decline with age in males as compared to females (Xie et al., 2006).
T144 19779-20057 Sentence denotes Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020).
T145 20058-20247 Sentence denotes ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon.
T146 20248-20457 Sentence denotes Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004).
T147 20458-20624 Sentence denotes In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010).
T148 20625-20715 Sentence denotes ACE2 distribution is widespread in the mouse brain, from the telencephalon to the medulla.
T149 20716-21122 Sentence denotes As expected, ACE2 is found in brain areas involved in the regulation of cardiovascular function and fluid balance, such as the vascular organ of lamina terminalis, subfornical organ, magnocellular neurons in the hypothalamic paraventricular nucleus, area postrema, nucleus of the solitary tract, dorsal motor nucleus of the vagus, nucleus ambiguous, and rostral ventrolateral medulla (Doobay et al., 2007).
T150 21123-21406 Sentence denotes However, significant expression had also been reported in brain areas not engaged in the classical functions of the RAAS, namely the piriform cortex, hippocampus, caudate putamen, hypoglossal nucleus and primary motor cortex (Doobay et al., 2007; Lin et al., 2008; Liu et al., 2014).
T151 21407-21544 Sentence denotes ACE2 immunostaining was identified in neurons as well as astrocytes (Gallagher et al., 2006; Doobay et al., 2007; Yamazato et al., 2007).
T152 21545-21715 Sentence denotes Furthermore, ACE2 has been documented in the retina, predominantly in the inner nuclear layer but also in photoreceptors (Tikellis et al., 2004; Senanayake et al., 2007).
T153 21716-21824 Sentence denotes With regard to the endocrine system, ACE2 expression was found in both male and female reproductive systems.
T154 21825-21962 Sentence denotes In human testis, ACE2 was localized to the Leydig and Sertoli cells, and might be involved in testicular function (Douglas et al., 2004).
T155 21963-22230 Sentence denotes At present, no data about ACE2 protein expression is human ovaries is available, although evidence of expression in stroma, theca, and granulosa cells has been reported in other species (Tonellotto dos Santos et al., 2012; Barreta et al., 2015; Pereira et al., 2015).
T156 22231-22344 Sentence denotes In rodent bone, ACE2 is expressed in osteoblasts and osteoclasts, as well as in epithelial cells and fibroblasts.
T157 22345-22449 Sentence denotes However, a similar expression in human samples still awaits clarification (Queiroz-Junior et al., 2019).
T158 22450-22575 Sentence denotes In human skin, ACE2 was present in the basal cell layer of the epidermis extending to the basal cell layer of hair follicles.
T159 22576-22657 Sentence denotes Smooth muscle cells surrounding the sebaceous glands were also positive for ACE2.
T160 22658-22722 Sentence denotes Weak cytoplasmic staining was observed in sebaceous gland cells.
T161 22723-22807 Sentence denotes A strong granular staining pattern for ACE2 was seen in cells of the eccrine glands.
T162 22808-22988 Sentence denotes Positive staining for ACE2 was also noted in the membrane of human fat cells in various organs, including the epicardial adipose tissue (Hamming et al., 2004; Patel et al., 2016a).
T163 22989-23099 Sentence denotes Globally, ACE2 is chiefly bound to cell membranes, while negligible levels can be detected in the circulation.
T164 23101-23143 Sentence denotes ACE2, the RAAS System and Cardioprotection
T165 23144-23408 Sentence denotes After the initial discovery of ACE2 in the heart and kidney, it is now clear that it is widely distributed in tissues (section Tissue Distribution of ACE2), where it exerts many physiological effects and may be involved in pathophysiological events (Turner, 2015).
T166 23409-23615 Sentence denotes The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II).
T167 23616-23842 Sentence denotes The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinning of the left ventricular wall.
T168 23843-23974 Sentence denotes Interestingly, in this knockout model disruption of the ACE pathway could rescue the myocardial phenotype (Crackower et al., 2002).
T169 23975-24110 Sentence denotes In another study, a selective ACE2 knockout model showed high blood pressure, worsened by the infusion of Ang-II (Gurley et al., 2006).
T170 24111-24249 Sentence denotes As a matter of fact, ACE2 displays its carboxypeptidase activity converting Ang-II to a heptapeptide, namely Ang1–7 (Turner et al., 2004).
T171 24250-24458 Sentence denotes ACE2 can also convert angiotensin I (Ang-I) to the non apeptide Ang1–9, which is in turn converted into Ang1–7 by ACE, competing with Ang-I and thus further decreasing Ang-II (Arendse et al., 2019; Figure 3).
T172 24459-24664 Sentence denotes Ang1–7 has been demonstrated to bind to the MasR receptor, which was initially regarded as an orphan receptor, since the use of a MasR antagonist caused inhibition of Ang1–7 effects (Alenina et al., 2008).
T173 24665-24898 Sentence denotes FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE.
T174 24899-25002 Sentence denotes ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs).
T175 25003-25141 Sentence denotes ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm.
T176 25142-25493 Sentence denotes In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016).
T177 25494-25741 Sentence denotes Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008).
T178 25742-25929 Sentence denotes In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI).
T179 25930-26264 Sentence denotes In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005).
T180 26265-26330 Sentence denotes Additional players contribute to ACE2-mediated cardio-protection.
T181 26331-26525 Sentence denotes Another substrate of ACE2 carboxypeptidase activity is Angiotensin A (Ang-A), identified in 2008, which has a similar, although less potent, vasopressor effect as AngII (Jankowski et al., 2007).
T182 26526-26669 Sentence denotes The product of the enzymatic reaction catalyzed by ACE2 is the peptide Ala-Ang (1–7) also known as alamandine (Lautner et al., 2013; Figure 3).
T183 26670-26805 Sentence denotes Alamandine receptor is a Mas-related G-protein coupled receptor, known as MrgD, which is expressed in cardiomyocytes and blood vessels.
T184 26806-26948 Sentence denotes MrgD knockout animals develop a severe cardiopathy and alamandine showed a cardioprotective effect in a model of sepsis (Santos et al., 2019).
T185 26949-27179 Sentence denotes Unlike ACE, ACE2 is not active on bradykinin, but it can degrade the active bradykinin metabolite des-Arg9 bradykinin (DABK), blocking the signaling pathway of the B1 bradykinin receptor (Vickers et al., 2002; Sodhi et al., 2018).
T186 27180-27287 Sentence denotes Other substrates of ACE2 include apelin-13/17, neurotensin, dynorphin A (1–13), and ghrelin (Turner, 2015).
T187 27288-27490 Sentence denotes Interestingly peptides of apelin family have been demonstrated to upregulate ACE2 expression in physiological condition and more actively during heart failure in in vivo experiments (Sato et al., 2013).
T188 27491-27755 Sentence denotes ACE2 in turn is able to regulate apelin bioavailability, establishing a negative feedback loop, and the crosstalk between RAAS, ACE2 and Apelin system might play a significant role in the pathophysiology of hypertension (Kalea and Batlle, 2010; Chen et al., 2015).
T189 27756-28110 Sentence denotes On the whole these findings suggest that ACE2 might exert antihypertensive and/or cardioprotective effects by different mechanisms, namely: (i) limiting the availability of ACE substrates, (ii) degrading Ang-II, (iii) activating the Ang1-7/MasR and/or Alamandine/MrgD pathways, (iv) interfering with other substrates, such as DABK and apelins (Figure 3).
T190 28112-28132 Sentence denotes ACE2 and Lung Injury
T191 28133-28267 Sentence denotes ACE2 is highly expressed in type I and II alveolar epithelial cells and in pulmonary small vessels (either endothelial cells or VSMC).
T192 28268-28574 Sentence denotes The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010).
T193 28575-28796 Sentence denotes ARDS is an overly aggressive form of ALI and it is the final mechanism of lung injury in many diseases, including sepsis, acid aspiration, pancreatitis, anthrax and virus infections (Spanish flu, H5N1 avian flu and SARS).
T194 28797-28942 Sentence denotes Imai et al. developed three ACE2 knockout mice models with severe ARDS induced by acid aspiration, endotoxin administration or peritoneal sepsis.
T195 28943-29164 Sentence denotes They showed that ARDS was accompanied by increased vessel permeability, lung oedema, and infiltration of inflammation cells, with consequent impairment of respiratory function (Imai et al., 2005, 2007; Kuba et al., 2006).
T196 29165-29309 Sentence denotes The phenotype was dramatically improved and rescued either administering ACE2 recombinant analogs or AT1Ra inhibitors (Imai et al., 2005, 2008).
T197 29310-29560 Sentence denotes ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012).
T198 29561-29759 Sentence denotes An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013).
T199 29760-29982 Sentence denotes The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015).
T200 29983-30061 Sentence denotes ACE2 might also modulate lung inflammation via the bradykinin-DABK/BKB1R axis.
T201 30062-30281 Sentence denotes In fact, decreased ACE2 function in mouse lungs caused increased activity of the DABK axis and triggered a proinflammatory cytokine storm (CXCL5, MIP2, KC, and TNF-α), leading to pulmonary collapse (Sodhi et al., 2018).
T202 30282-30345 Sentence denotes In human, ACE/ACE2 imbalance may be related to genetic factors.
T203 30346-30570 Sentence denotes In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002).
T204 30571-30791 Sentence denotes More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014).
T205 30793-30824 Sentence denotes Links Between ACE2 and COVID-19
T206 30825-31073 Sentence denotes A “second life” for ACE2 was discovered in 2003, when a novel respiratory infective disease, known as severe acute respiratory syndrome (SARS), appeared in China and spread all over Asia and Canada, with a lethality rate of 10% (Rota et al., 2003).
T207 31074-31223 Sentence denotes The responsible pathogen was identified in a positive strand RNA virus belonging to the coronavirus family and named SARS-CoV (Ksiazek et al., 2003).
T208 31224-31444 Sentence denotes The virus genome was sequenced and this allowed the identification of the spike glycoprotein (S), whose N-terminal portion, or S1-domain, was found to mediate the high affinity binding to host cells (Marra et al., 2003).
T209 31445-31732 Sentence denotes The group of Farzan et al. succeeded in identifying the cell receptor: they showed that SARS-CoV efficiently infected African Monkey kidney cell line Vero E6 and co-immunoprecipitated a glycoprotein responsible for virus binding and entry, which was identified as ACE2 (Li et al., 2003).
T210 31733-31839 Sentence denotes SARS-CoV caused the SARS epidemic in 2002–2003, with over 8,000 infections and a fatality rate around 10%.
T211 31840-32036 Sentence denotes In late 2019, another coronavirus emerged as a human pathogen in the city of Wuhan in China, producing symptoms such as fever, severe respiratory impairment, and pneumonia (Petersen et al., 2020).
T212 32037-32215 Sentence denotes This new coronavirus has been denominated SARS-CoV-2 for its genetic resemblance with SARS-CoV (∼80%), and its related disease has been named COVID-19 (COronaVIrus Disease 2019).
T213 32216-32376 Sentence denotes Owing to its high reproduction number R0 (2–3), SARS-CoV-2 has rapidly diffused in several countries and is currently posing a significant global health threat.
T214 32377-32450 Sentence denotes On March 11, 2020, the WHO has declared the COVID-19 outbreak a pandemic.
T215 32451-32645 Sentence denotes The early discovery that SARS-CoV-2 also engages ACE2 as entry door for cell infection has prompted an intense research effort to elucidate the biochemical determinants of CoV-ACE2 interactions.
T216 32647-32697 Sentence denotes Mechanism of Viral Entry Mediated by the S Protein
T217 32698-32823 Sentence denotes A coronavirus contains four structural proteins, namely spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins.
T218 32824-32950 Sentence denotes These proteins assemble around a lipid bilayer to provide the shell enclosing the viral genome (Figure 4A; Tang et al., 2020).
T219 32951-33142 Sentence denotes Homotrimers of S protrude from the viral surface, and are densely decorated by N-linked glycans, creating the “crown” (“Corona” in Latin) that christens this virus group (Walls et al., 2016).
T220 33143-33297 Sentence denotes S is a ∼180 kDa glycoprotein anchored in the viral membrane, which plays the most important roles in viral attachment, fusion and entry (Ou et al., 2020).
T221 33298-33448 Sentence denotes Sequence analysis has shown that SARS-CoV-2 S protein shares 76% of the primary sequence with the corresponding S of human SARS-CoV (Ou et al., 2020).
T222 33449-33579 Sentence denotes Accordingly, it has been early proposed that SARS-CoV-2 utilizes a similar cell entry mechanism as SARS-CoV, pivoted on S protein.
T223 33580-33650 Sentence denotes This hypothesis has been confirmed from an experimental point of view.
T224 33651-33863 Sentence denotes By using pseudotyped virus bearing SARS-CoV S or SARS-CoV-2 S, it was shown that a large panel of cell lines allows comparable entry of SARS-CoV or SARS-CoV-2 viruses (Hoffmann et al., 2020b; Walls et al., 2020).
T225 33864-33996 Sentence denotes FIGURE 4 (A) Structure of a Coronavirus. (B) Functional motifs in the sequence of the S “spike” protein of SARS-CoV and SARS-CoV-2.
T226 33997-34278 Sentence denotes The S protein consists of ∼1300 aminoacids and it is composed by a N-terminal “S1”subunit (∼700 aa) and a C-terminal “S2”subunit (∼600 aa); binding to the host receptor is mediated by S1, whereas S2 induces fusion of the viral envelope with cellular membranes (Walls et al., 2017).
T227 34279-34405 Sentence denotes S1 and S2 can be further subdivided in functional segments with different roles in viral entry (Figure 4B; Tang et al., 2020).
T228 34406-34506 Sentence denotes The S1 subunit contains two subdomains, the N-terminal domain (NTD) and the C-terminal domain (CTD).
T229 34507-34710 Sentence denotes In SARS-CoV (Li, 2015) and SARS-CoV-2 (Wang et al., 2020) CTD encloses the receptor-binding domain (RBD), and the RBD section that directly contacts the receptor is named as receptor-binding motif (RBM).
T230 34711-34864 Sentence denotes The N-region of S2 contains a fusion peptide (FP), two heptapeptide repeat domains (HR1, HR2), a transmembrane domain (TM), and cytoplasmic peptide (CP).
T231 34865-35032 Sentence denotes FP is a short segment composed of mostly hydrophobic residues, such as glycine (G) or alanine (A), which inserts in the host cell membrane to trigger the fusion event.
T232 35033-35216 Sentence denotes HR1 and HR2 are composed of a repetitive heptapeptide with HPPHCPC sequence, where H represents hydrophobic or bulky residues, P polar or hydrophilic residues, and C charged residues.
T233 35217-35315 Sentence denotes HR regions typically fold into α-helices with a hydrophobic interface that drives membrane fusion.
T234 35316-35513 Sentence denotes On the basis of the strong similarity between the S proteins of SARS-CoV and SARS-CoV-2, many researchers early set-out to demonstrate whether both viruses target the same host cell receptor, ACE2.
T235 35514-35672 Sentence denotes Zhou et al. (2020) highlighted that the virus was able to infect cell lines only when they expressed human, bat, civet, and pig (but not mouse) ACE2 receptor.
T236 35673-35864 Sentence denotes Hoffmann et al. (2020b), Ou et al. (2020), and Walls et al. (2020) elegantly outlined that the BHK cell line could be infected by pseudotyped SARS-CoV-2 or SARS-CoV only upon ACE2 expression.
T237 35865-36070 Sentence denotes Conversely, the expression of different human receptors used by other CoVs (hDPP4 and APN, used by MERS CoV and HCoV-229E, respectively) did not enable pseudovirus access to cells (Hoffmann et al., 2020b).
T238 36071-36165 Sentence denotes Taken together, these findings are solid evidence that SARS-CoV-2 engages ACE2 for cell entry.
T239 36166-36389 Sentence denotes Nonetheless, the two viruses were demonstrated by Xia to share also the membrane fusion mechanism, as strongly suggested by the impressive 89.9% sequence identity of S2 between SARS-CoV and SARS-CoV-2 (Xia et al., 2020a,b).
T240 36390-36615 Sentence denotes To date, the cell entry mechanism of SARS-CoV and SARS-CoV-2 has been understood in its general details and it is based on a concerted action of receptor binding and proteolysis of the S protein (Figure 5; Tang et al., 2020).
T241 36616-36807 Sentence denotes Ultrastructural studies showed a metastable “prefusion” V-shaped trimer composed by three S1 heads sitting on top of a trimeric S2 stalk anchored into the virus membrane (Walls et al., 2016).
T242 36808-37025 Sentence denotes The RBD constantly switches between a standing-up (“open”) position for receptor binding and a lying-down (“closed”) configuration, the latter allowing immune evasion (Figure 6; Song et al., 2018; Wrapp et al., 2020).
T243 37026-37144 Sentence denotes Yet only one of the three RBD in trimeric S can flip up at a time and interact with the receptor (Wrapp et al., 2020).
T244 37145-37307 Sentence denotes The second key feature of the fusion mechanism is “priming” by host proteases, which recognize and cleave a short peptide motif at the S1/S2 boundary (Figure 4B).
T245 37308-37671 Sentence denotes This cleavage does not disassemble S1 from S2 in pre-fusion conditions (Belouzard et al., 2009), but the binding interaction of RBD with its receptor, accompanied by a further cleavage in a second site in S2 (S2’site, upstream of FP, Figure 4B), triggers the possible dissociation of S1 and the irreversible refolding of S2 into a “post-fusion” state (Figure 4B).
T246 37672-37907 Sentence denotes In detail, HR1 undergoes a dramatic “jack-knife” conformational change, converting four helical stretches that run in an antiparallel fashion into a single long (∼130 aa) α-helix (Heald-Sargent and Gallagher, 2012; Walls et al., 2017).
T247 37908-38022 Sentence denotes At first, three of these helices assemble into a homotrimeric bundle and stick the FP into the host cell membrane.
T248 38023-38177 Sentence denotes Then, HR2 (one for each S2 chain) fold backward and bind to HR1, yielding the “six-helix bundle fusion core” (6-HB) of post-fusion S2 (Song et al., 2018).
T249 38178-38410 Sentence denotes This conformational foldback brings the FP (at N-terminus of HR1) and the TM (at the C terminus of HR2) close to each other, so that the viral and host cell membranes approach until their outer leaflets merge (hemifusion, Figure 5).
T250 38411-38621 Sentence denotes Eventually the inner leaflets merge (pore formation), enabling a connection between the interior of the virus and the host cell cytoplasm, that allows the delivery of viral genome (Figure 5; Tang et al., 2020).
T251 38622-38671 Sentence denotes FIGURE 5 Coronavirus viral fusion pathway model.
T252 38672-38735 Sentence denotes Initially, the S protein is in the pre-fusion native state (1).
T253 38736-39034 Sentence denotes Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2).
T254 39035-39214 Sentence denotes Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3).
T255 39215-39329 Sentence denotes The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state.
T256 39330-39500 Sentence denotes During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation).
T257 39501-39622 Sentence denotes Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle).
T258 39623-39655 Sentence denotes Adapted from Tang et al. (2020).
T259 39656-39732 Sentence denotes FIGURE 6 Trimeric S protein of SARS-CoV-2 in the ”Closed” and “Open” forms.
T260 39733-39821 Sentence denotes Note the single RBD protruding out of the V-shaped conformation of the protein assembly.
T261 39822-39870 Sentence denotes The structures have been drawn from PDB 6X2C (R.
T262 39871-39934 Sentence denotes Henderson, 10.1101/2020.05.18.10208) by Mol on the PDB website.
T263 39935-40104 Sentence denotes Although not directly related to ACE2, the role of S “priming” by host cell proteases deserves particular attention in the context of SARS-CoV-2 virus entry and tropism.
T264 40105-40317 Sentence denotes Possibly, the most notable feature of SARS-CoV-2 genome, as compared to SARS-CoV and some related bat coronaviruses, is a four basic aminoacid insert (PRRA) at the S1/S2 junction (Figure 4B; Jaimes et al., 2020).
T265 40318-40473 Sentence denotes This site is potentially cleavable by the protease furin, a proprotein convertase widely recognized to activate the fusion machinery of viral glycoprotein.
T266 40474-40706 Sentence denotes Indeed, many authors showed that pseudoviruses bearing SARS-CoV-2 S were already “primed” (i.e., cleaved) at the S1/S2 boundary by furin upon assembly in the cell, at odds with pseudoviruses bearing SARS-CoV S (Shang et al., 2020a).
T267 40707-41100 Sentence denotes SARS-COV-2 shows a large flexibility with regard to protease priming, which may independently occur by a) furin and furin-like proteases intracellularly, b) trypsin-like proteases such as TMPRSS2 that are present on the host cell membrane (particularly on airway epithelial cells), and 3) endosomal cathepsins activated by a drop in pH (e.g., cathepsin L) (Figure 7; Hoffmann et al., 2020a,b).
T268 41101-41252 Sentence denotes This flexibility could be the crucial factor that explain SARS-CoV-2 cell tropism and the peculiar features of COVID-19 symptoms (Jaimes et al., 2020).
T269 41253-41438 Sentence denotes Additionally, the kind of protease “priming” may determine whether the membrane fusion process occur directly at the plasma membrane or at endosomal level (Tang et al., 2020; Figure 7).
T270 41439-41524 Sentence denotes FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells.
T271 41525-41685 Sentence denotes The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell.
T272 41686-41911 Sentence denotes The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA.
T273 41912-42222 Sentence denotes Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles.
T274 42223-42333 Sentence denotes Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell.
T275 42335-42372 Sentence denotes SARS-CoV-2 RBD and Its Receptor, ACE2
T276 42373-42520 Sentence denotes Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV.
T277 42521-42597 Sentence denotes SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005).
T278 42598-42737 Sentence denotes Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020).
T279 42738-42868 Sentence denotes Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy.
T280 42869-43072 Sentence denotes Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor).
T281 43073-43202 Sentence denotes Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner.
T282 43203-43279 Sentence denotes The SARS-CoV-2 RBD sequence was further investigated by structural analysis.
T283 43280-43677 Sentence denotes X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020).
T284 43678-43945 Sentence denotes In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference.
T285 43946-44180 Sentence denotes FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue.
T286 44181-44253 Sentence denotes The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A).
T287 44254-44344 Sentence denotes The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website.
T288 44345-44422 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 44423-44509 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 44510-44670 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 44671-44785 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 44786-44934 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 44935-45126 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 45127-45344 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 45345-45522 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 45523-45766 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 45767-46093 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 46094-46211 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.
T299 46212-46305 Sentence denotes TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2.
T300 46306-46343 Sentence denotes Sequence KD (nM) Method References
T301 46344-46383 Sentence denotes SARS-2 S 14.7 SPR Wrapp et al., 2020
T302 46384-46421 Sentence denotes SARS-2 S 11.2 SPR Lei et al., 2020
T303 46422-46471 Sentence denotes SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020
T304 46472-46524 Sentence denotes SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020
T305 46525-46574 Sentence denotes SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020
T306 46575-46622 Sentence denotes SARS-2 S319–529 44.2 SPR Shang et al., 2020b
T307 46623-46689 Sentence denotes SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020
T308 46690-46755 Sentence denotes SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020
T309 46757-46790 Sentence denotes Structure of the ACE2-RBD Complex
T310 46791-47024 Sentence denotes Previous studies showed that the extracellular Peptidase Domain (PD) of ACE2, which adopts a claw-like morphology, is the interaction site of SARS-CoV RBD (Towler et al., 2004; Li, 2015; Kirchdoerfer et al., 2018; Song et al., 2018).
T311 47025-47199 Sentence denotes More specifically, ACE2 engages SARS-CoV RBD by establishing contacts with the 424–494 residue domain, which is referred to as Receptor Binding Motif (RBM) (Li et al., 2005).
T312 47200-47480 Sentence denotes In spite of the recent emergence of SARS-CoV-2, multiple authors have already highlighted the structure of ACE2/SARS-CoV-2 RBD complex by either X-ray (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020) or cryo-EM (Walls et al., 2020; Wrapp et al., 2020; Yan et al., 2020).
T313 47481-47591 Sentence denotes Pleasantly, all data converged to a consistent tridimensional arrangement of the receptor (Wang et al., 2020).
T314 47592-47709 Sentence denotes In the “closed” conformation of S protein, the RBD is buried at the interface between protomers (Walls et al., 2020).
T315 47710-47892 Sentence denotes Only in the “open” S conformation, RBD engages PD of ACE2 (Wrapp et al., 2020), and the complex may involve a dimeric ACE2 that accommodates two S protein trimers (Yan et al., 2020).
T316 47893-48082 Sentence denotes In keeping with their sequence similarity, strong structural homology was found between ACE2/SARS-CoV RBD and ACE2/SARS-CoV-2 RBD (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020).
T317 48083-48271 Sentence denotes SARS-CoV-2 RBM spans from residue 438–506 of S sequence and, likewise SARS-CoV RBM, it approaches the outer surface of ACE2 by a gently concave surface with a ridge on one side (Figure 8).
T318 48272-48437 Sentence denotes The concave surface is made up by the two short β5 and β6 sheets of the external RBD subdomain, whereas the ridge contains the β5/β6 loop (loop 1: residues 474–489).
T319 48438-48539 Sentence denotes A second smaller loop (loop 2: residues 498–505) is visible on the other side of the concave surface.
T320 48540-48805 Sentence denotes Inspection of the complex structure and molecular dynamics (MD) highlighted that the motifs 453–456 (in β5), 484–489 (in the loop 1), and 500–505 (in the loop 2) are at the basis of the largest differences between SARS-CoV-2 and SARS-CoV RBM interactions with ACE2.
T321 48806-49060 Sentence denotes SARS-CoV RBM ridge contains a Pro-Pro-Ala motif that is replaced by Gly-Val-Glu-Gly in SARS-CoV-2 (residues 482–485), yielding a more compact loop able to engage more interactions with proximal ACE2 residues (e.g., Ser19 and Gln24) (Shang et al., 2020b).
T322 49061-49269 Sentence denotes Additionally, Phe486 of SARS-CoV-2 RBM (which replaces Ile of SARS) inserts into a hydrophobic pocket on the receptor surface, establishing strong aromatic interactions with Tyr83 of ACE2 (Wang et al., 2020).
T323 49270-49365 Sentence denotes Asn501 in loop 2 further engages recognized hotspots on the ACE2 surface (Shang et al., 2020b).
T324 49366-49517 Sentence denotes Consistently, MD studies confirmed that loop 1 and 2 are much more rigid in RBM-ACE2 complex of SARS-CoV-2 with respect to SARS (Brielle et al., 2020).
T325 49518-49638 Sentence denotes These subtle structural differences probably account for the higher affinity of SARS-CoV-2 for ACE2 (Wang et al., 2020).
T326 49639-49848 Sentence denotes Interestingly, MD simulations suggest that the difference in affinity is largely due to the solvation energy, emphasizing the relevant role of hydrophobic patches in RBM/ACE2 binding surface (He et al., 2020).
T327 49849-50116 Sentence denotes It is worth noting that the RBD-receptor engagement is the crucial effector of viral-host interaction, which eventually determines viral host range, and in tandem with the host proteases is responsible for virus tropism and pathogenicity (Millet and Whittaker, 2015).
T328 50117-50351 Sentence denotes Structure-guided sequence analysis has suggested that several mammals, including pets such as cats and dogs, host ACE2 receptors that could bind effectively to SARS-CoV-2 S protein and propagate COVID-19 infection (Luan et al., 2020).
T329 50352-50434 Sentence denotes Yet, no correlation between genetic distance and the S/ACE2 interaction was found.
T330 50435-50646 Sentence denotes In this context, a third human CoV, hCoV-NL63, has been previously found to use ACE2 for cell entry (Hofmann et al., 2005), although its S1 sequence is rather dissimilar from SARS (23.4%) and SARS-CoV-2 (29.2%).
T331 50647-50819 Sentence denotes In spite of this, the structures of hCoV-NL63 (Wu et al., 2009) and SARS-CoV RBD (Li et al., 2005) were found to engage some sterically overlapping sites in ACE (Li, 2015).
T332 50820-50980 Sentence denotes This homology can be transitively extended to SARS-CoV-2, suggesting these three CoVs have evolved to recognize a “hotspot” region in ACE2 for receptor binding.
T333 50981-51174 Sentence denotes This might represent a critical feature for the appearance of novel CoV able to infect humans in the future, as it is known that at least three more bat CoVs bind ACE2 (Hoffmann et al., 2020b).
T334 51175-51398 Sentence denotes Indeed, bat RaTG13 CoV binds ACE2 and contains a similar four-residue motif in the ACE2 binding ridge of RBM, suggesting that SARS-CoV-2 could have evolved from RaTG13 or a yet-unknown related bat CoV (Shang et al., 2020b).
T335 51400-51441 Sentence denotes The Controversial Role of ACE2 Expression
T336 51442-51682 Sentence denotes Epidemiological data consistently show that the COVID-19 patients at highest risk of a poor prognosis are males older than 60 years with chronic underlying diseases, mostly hypertension, cardiovascular diseases and type-2 diabetes mellitus.
T337 51683-51865 Sentence denotes Clinical reports have been rapidly delivered from all over the world, and meta-analyses assessing the prevalence of comorbidities and their impact on prognosis are already available.
T338 51866-52113 Sentence denotes A meta-analysis pooling data from seven studies following a total number of 1,576 infected patients from hospitals in China found that the most prevalent comorbidities were hypertension (21.1%), diabetes (9.7%), and cardiovascular diseases (8.4%).
T339 52114-52322 Sentence denotes These increased the risk of developing a more serious disease (i.e., requiring intensive care treatment), with odds ratios ranging from 2.4 (hypertension) to 3.4 (cardiovascular disease) (Yang et al., 2020b).
T340 52323-52598 Sentence denotes These findings have been confirmed in the analysis performed by the Chinese Center for Disease Control and Prevention in a huge sample of 72314 COVID-19 cases (Epidemiology Working Group for Ncip Epidemic Response and Chinese Center for Disease Control and Prevention, 2020).
T341 52599-52752 Sentence denotes A study with 1591 Italian patients, similarly, reported a significant association between hypertension and mortality in Intensive Care Unit (63 vs. 40%).
T342 52753-52897 Sentence denotes This series reported an even higher prevalence of hypertension (49%), diabetes (17%), and cardiovascular disease (21%) (Grasselli et al., 2020).
T343 52898-53086 Sentence denotes Diabetes has been reported to predict the occurrence of ARDS (HR = 1.44), acute kidney injury (HR = 3.01), septic shock (HR = 1.95), and all-cause mortality (HR = 1.70) (Zhu et al., 2020).
T344 53087-53245 Sentence denotes Notably, poor glycemic control was significantly associated with worse clinical outcomes, namely multi-organ injuries and higher mortality (Zhu et al., 2020).
T345 53246-53327 Sentence denotes Obesity has also emerged as an important factor in determining COVID-19 severity.
T346 53328-53596 Sentence denotes Indeed, obesity was more frequent in patients admitted to critical care for SARS-CoV-2 as compared to the general population; moreover, the BMI was positively related to the need for invasive mechanical ventilation and mortality (Drucker, 2020; Simonnet et al., 2020).
T347 53597-53739 Sentence denotes The RAAS system is the target of widely used anti-hypertensive drugs, such as ACE-inhibitors (ACEI) and Ang-II type 1 receptor blockers (ARB).
T348 53740-53952 Sentence denotes Several experimental studies reported that, although not directly affecting ACE2 activity, these drugs are able to upregulate its expression (Ishiyama et al., 2004; Ferrario et al., 2005; Gallagher et al., 2008).
T349 53953-54185 Sentence denotes Increased expression of ACE2 has also been reported to facilitate SARS-CoV infection in several experimental models and postulated to act in the same way for SARS-CoV-2 (Li et al., 2003; Hofmann et al., 2004; Perrotta et al., 2020).
T350 54186-54356 Sentence denotes Hence, following the SARS-CoV-2 outbreak, it has been speculated that the use of ACEI and ARB could increase viral invasion and should therefore be temporarily suspended.
T351 54357-54825 Sentence denotes This topic has been abundantly debated in the last few months (March–May 2020), with contradictory views (Bavishi et al., 2020; Buckley et al., 2020; Danser et al., 2020; Fang et al., 2020; Huang Z. et al., 2020; Kreutz et al., 2020; Kuster et al., 2020; Mourad and Levy, 2020; Park et al., 2020; Rico-Mesa et al., 2020; Sommerstein et al., 2020; South et al., 2020; Tignanelli et al., 2020; Vaduganathan et al., 2020; Verdecchia et al., 2020b; Zhang P. et al., 2020).
T352 54826-55215 Sentence denotes As a consequence of this debate, several clinical societies have stated that suspension of ACEI and ARB is not justified on the basis of the present scientific evidence, although a recent BMJ editorial (Aronson and Ferner, 2020) suggested to consider stopping ACE inhibitors or angiotensin receptor blockers in patients with mild hypertension who are at high risk of coronavirus infection.
T353 55216-55441 Sentence denotes On the other hand, a different viewpoint is based on the intriguing observation that several conditions increasing the risk of viral infection and disease severity are all characterized by a certain degree of ACE2 deficiency.
T354 55442-55629 Sentence denotes As discussed above (section “Structure of ACE2”) ACE2 deficiency has been suggested to play a significant role in the pathophysiology of hypertension, cardiovascular disease and diabetes.
T355 55630-55827 Sentence denotes The role of ACE2 expression in the panel of comorbidities correlated to SARS-CoV-2 is a matter of intense still unsolved debate, as brilliantly revised by Shyh et al. (2020) in a very recent paper.
T356 55828-55967 Sentence denotes On the whole, there is still uncertainty about the relationship between ACE2 density on cell membrane and the fate of SARS-CoV-2 infection.
T357 55968-56309 Sentence denotes An interesting speculation which could reconcile the two position comes from the hypothesis that while ACE2 is for sure the entry door for the virus, once the infection has evolved, there is the subsequent downregulation of ACE2, responsible for the precipitating of respiratory distress, as showed also in animal models (Kuba et al., 2005).
T358 56310-56482 Sentence denotes It should be pointed out that the great clinical impact of this issue has encouraged discussions that are largely based on indirect speculations rather than objective data.
T359 56483-56776 Sentence denotes Data from appropriate clinical trials are still lacking, although a retrospective multicenter study on more than 1,000 patients with COVID-19 and hypertension treated with ACEI or ARB revealed that the use of these drugs was associated with lower mortality from all cause (Bosso et al., 2020).
T360 56777-57181 Sentence denotes A definite conclusion would require specific prospective clinical trials, which are still running: https://clinicaltrials.gov/ct2/show/NCT04312009 is a multi-centered double blind trial with the aim to test the role of ARB in patients with COVID-19 and https://clinicaltrials.gov/ct2/show/NCT04331574 is another trial evaluating the outcome of patients with COVID-19 in therapy with either ACEI and ARBS.
T361 57182-57737 Sentence denotes In the meanwhile, partial but important information might be obtained by circumscribed experimental and clinical investigations focused some on crucial issues, namely: fate of SARS-CoV-2 infection in human cells manipulated in order to modify ACE2 density; correlation of ACE2 density (in different cell types) and clinical course in human patients; potential role of additional proteins interacting with ACE2, such as the membrane transporter SIT1, which appears to be associated with COVID-19 prognosis and is also affected by anti-hypertensive therapy.
T362 57739-57787 Sentence denotes ACE2 and the Inflammatory Response to SARS-CoV-2
T363 57788-57954 Sentence denotes Differently from other flu-like viral infections, COVID19 showed a relatively high lethality, although the latter was quite different in different geographical areas.
T364 57955-58114 Sentence denotes The appearance of ARDS and acute severe lung injury was initially regarded as the main insult, and patients underwent the typical treatment developed for ARDS.
T365 58115-58430 Sentence denotes However, more recent evidence from autopsy series revealed that COVID-19 is a systemic disease, in which interstitial pneumonia is associated with extensive microvascular damage, which is not limited to the lungs and leads to fibrin deposition, neutrophils trapping in microvasculature, and arteriolar microthrombi.
T366 58431-58585 Sentence denotes Moreover, cardiovascular involvement has been observed, occasionally leading to myocardial injury and sudden death after weeks from the initial infection.
T367 58586-58757 Sentence denotes These findings are crucial to optimize the treatment of COVID-19 patients, hopefully improving the prognosis (Buja et al., 2020; Carsana et al., 2020; Magro et al., 2020).
T368 58758-58906 Sentence denotes Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection.
T369 58907-59045 Sentence denotes Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia.
T370 59046-59144 Sentence denotes In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required.
T371 59145-59270 Sentence denotes These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people.
T372 59271-59586 Sentence denotes Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020).
T373 59587-59705 Sentence denotes The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood.
T374 59706-59919 Sentence denotes As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes).
T375 59920-60048 Sentence denotes This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020).
T376 60049-60299 Sentence denotes The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016).
T377 60300-60546 Sentence denotes In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane.
T378 60547-60992 Sentence denotes One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9).
T379 60993-61100 Sentence denotes FIGURE 9 Possible role of ACE2 in the molecular mechanisms involved in the “cytokine storm” of SARS-CoV-2.
T380 61101-61322 Sentence denotes In the SARS-CoV-2 infection, pyroptosis has been demonstrated to be active in macrophages, being viroporin 3a a trigger for NLRP3 with subsequent production of proinflammatory cytokines, such as IL-1β (Chen et al., 2019).
T381 61323-61461 Sentence denotes In COVID-19 patients, the pyroptosis activation has been indirectly demonstrated by the high serum level of IL-1β (Huang C. et al., 2020).
T382 61462-61649 Sentence denotes Moreover, the severe leucopoenia and lymphopenia, commonly showed in COVID-19 pneumonia and associated with poor prognosis, are likely due to lymphocyte injury by pyroptosis (Yang, 2020).
T383 61650-61775 Sentence denotes Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system.
T384 61776-62072 Sentence denotes It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018).
T385 62073-62417 Sentence denotes The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release.
T386 62418-62657 Sentence denotes Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020).
T387 62658-62754 Sentence denotes The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm.
T388 62755-62951 Sentence denotes The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).
T389 62952-63040 Sentence denotes ACE2 shedding is an additional mechanism contributing to inflammation (Fu et al., 2020).
T390 63041-63294 Sentence denotes ACE2 shedding consists in proteolytic cleavage of the protein ectodomain and leads to the release of enzymatically active soluble ACE2 (sACE), whose action is not completely understood, but might enhance the pro-inflammatory response (Guy et al., 2005).
T391 63295-63510 Sentence denotes ADAM 17 and disintegrin are able to shed not only TNFα but also a variety of membrane-anchored enzymes, including ACE2 (Black et al., 1997; Palau et al., 2020), as demonstrated by Lambert in 2005 (Guy et al., 2005).
T392 63511-63827 Sentence denotes In their experiment, human embryonic kidney cells (HEK293) expressing human ACE2 (HEK-ACE2) were treated with phorbol myristate acetate stimulation and the production of a polypeptide of 105 kDa was demonstrated by western blot analysis, suggesting the occurrence of a proteolytic shedding in the ectodomain of ACE2.
T393 63828-64048 Sentence denotes Subsequently, they demonstrated that the cleavage was performed by ADAM17, incubating cells with a specific hydroxamic acid-based metalloproteinase inhibitor, namely TAPI-1 (TNFα protease inhibitor 1) (Guy et al., 2005).
T394 64049-64166 Sentence denotes ACE2 shedding seems to be inducible by specific stimuli produced either by a viral infection or by the immune system.
T395 64167-64280 Sentence denotes Jia et al. (2009) confirmed ACE2 shedding in differentiated primary airway epithelial cells and Calu-3-cell line.
T396 64281-64489 Sentence denotes Furthermore, they demonstrated that the incubation with IL-1β at the dosage of 100 ng/ml and TNF α 100 ng/ml induced ACE2 shedding and sACE release, with a maximum after 18 h of incubation (Jia et al., 2009).
T397 64490-64625 Sentence denotes These findings suggest that an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection.
T398 64626-64810 Sentence denotes Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).
T399 64811-64970 Sentence denotes Other conditions have been assumed to be involved in the susceptibility to SARS-CoV-2 and among them vitamin D deficiency was proposed as a credible candidate.
T400 64971-65132 Sentence denotes The interesting candidate could be identified as a modifiable risk factor (hypovitaminosis D) and a potential tool in COVID-19 prevention or ancillary treatment.
T401 65133-65789 Sentence denotes The rationale has been summarized by Grant et al. in a recent review on the evidence supporting a possible correlation between vitamin D and SARS-CoV-2 risk: (i) the seasonal flare of SARS-CoV-2 which coincides with the nadir of vitamin D levels, (ii) the association between hypovitaminosis D and pulmonary infections together with the demonstrated protective role in acute respiratory infections, in adults (iii) the anti-inflammatory role of vitamin D which could be of benefit against the so called “cytokine storm,” which seems to be a major player in SARS-CoV-2 morbidity and mortality (Martineau et al., 2017; Zhou et al., 2019; Grant et al., 2020).
T402 65791-65819 Sentence denotes ACE2 as a Therapeutic Target
T403 65820-65908 Sentence denotes As evidence builds up, ACE2 rapidly emerged as a specific target for COVID-19 treatment.
T404 65909-66213 Sentence denotes Since this enzyme was identified as the SARS-CoV-2 receptor (Zhou et al., 2020), several approaches to address ACE2 mediated infection have been described (Li Y. et al., 2020; Zhang H. et al., 2020), with the aim to prevent host cell entry and subsequent viral replication, as well as severe lung injury.
T405 66214-66267 Sentence denotes Potential therapeutic approaches include (Figure 10):
T406 66268-66379 Sentence denotes FIGURE 10 Schematic representation of the potential therapeutic approaches to address ACE2 mediated infection.
T407 66380-66584 Sentence denotes Exogenous administration of soluble recombinant human ACE 2 sequesters circulating viral particles, while specific ACE2 blockers bind the receptor, impeding the S-protein interaction with the host target.
T408 66585-66587 Sentence denotes 1.
T409 66589-66603 Sentence denotes ACE2 blockers;
T410 66604-66606 Sentence denotes 2.
T411 66608-66641 Sentence denotes Exogenous administration of ACE2.
T412 66643-66656 Sentence denotes ACE2 Blockers
T413 66657-66907 Sentence denotes Blockade of ACE2 receptor could be achieved through specific antibodies (Li et al., 2003), rationally designed small molecules (Dales et al., 2002; Huentelman et al., 2004; Gross et al., 2020; Pillaiyar et al., 2020) or peptides (Huang et al., 2003).
T414 66908-67096 Sentence denotes Although their efficacy needs to be confirmed, some of these agents are currently available on the market and have been show to effectively block SARS-CoV invasion (Li S.-R. et al., 2020).
T415 67097-67424 Sentence denotes For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004).
T416 67425-67623 Sentence denotes Therefore, although ACE2 catalytic site is distinct from the S-protein-binding domain, NAAE exerts dual inhibitory effects on ACE2 catalytic activity and SARS binding (Adedeji and Sarafianos, 2014).
T417 67624-67920 Sentence denotes However, since a protecting role for ACE2 receptor against virus-induced acute lung injury in infections with SARS coronavirus has not been excluded (Imai et al., 2005; Kuba et al., 2005; Li S.-R. et al., 2020), the choice of ACE2 inhibition as therapeutic approach should be carefully evaluated.
T418 67922-67954 Sentence denotes Exogenous Administration of ACE2
T419 67955-68363 Sentence denotes The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a).
T420 68364-68543 Sentence denotes A pilot clinical study is currently investigating the efficiency of a recombinant human angiotensin-converting enzyme 2 (rhACE2) in patients with COVID-19 (Zhang H. et al., 2020).
T421 68544-68748 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 68749-69104 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 69105-69311 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 69312-69473 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 69474-69680 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.
T426 69681-69910 Sentence denotes Additionally, the availability of ACE2 nanoparticles applied to nose filters, chewing gums, clothes, filters and gloves could be of help in sequestering the virus thus preventing its entry into the host (Aydemir and Ulusu, 2020).
T427 69911-70143 Sentence denotes Prevention virus transmission could represent a more convenient strategy than therapeutic interventions on viral infection, avoiding interference with ACE2 and disturbance of the finely regulated RAAS axis (Aydemir and Ulusu, 2020).
T428 70145-70168 Sentence denotes ACE2 and Other Diseases
T429 70169-70223 Sentence denotes ACE2 is a multiform protein (Feng et al., 2010, 2011).
T430 70224-70414 Sentence denotes As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013).
T431 70415-70527 Sentence denotes Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis.
T432 70528-70645 Sentence denotes Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012).
T433 70646-70743 Sentence denotes Moreover, ACE2 participates in the regulation of metabolism, particularly of glucose homeostasis.
T434 70744-70851 Sentence denotes In the pancreas, activation of the ACE2-Ang1-7-MasR pathway improves insulin secretion (Yuan et al., 2013).
T435 70852-71038 Sentence denotes Obesity and high-fat diets cause a reduction in ACE2 expression in the adipose tissue, which in turn results in increased blood pressure (Gupte et al., 2008, 2012; Carsana et al., 2020).
T436 71039-71184 Sentence denotes A role for ACE2 is emerging in Alzheimer disease, since it has been shown that ACE2 can hydrolyse Beta amyloid peptides (Zou et al., 2007, 2013).
T437 71185-71268 Sentence denotes There is also increasing evidence that the RAAS system may be implicated in cancer.
T438 71269-71469 Sentence denotes ACE2 was found to inhibit cancer cell growth, metastasis, and angiogenesis in breast (Yu et al., 2016; Zhang Q. et al., 2019), pancreatic (Zhou et al., 2011), and colon cancer (Bernardi et al., 2012).
T439 71470-71679 Sentence denotes Another study pointed out that hepatocellular carcinoma patients with higher levels of ACE2 had longer survival times, suggesting a positive link between ACE2 expression and better prognosis (Ye et al., 2015).
T440 71680-71846 Sentence denotes Studies on human xenografts in mice clearly indicated that ACE2 inhibited tumor growth by suppressing invasion and angiogenesis in Non-Small Cell Lung Cancer (NSCLC).
T441 71847-72120 Sentence denotes Remarkably, the same group demonstrated that overexpression of ACE2 promotes the expression of E-cadherin at expenses of mesenchymal markers such as vimentin, and thereby inhibits the epithelial-mesenchymal transition in NSCLC models (Feng et al., 2010; Qian et al., 2013).
T442 72121-72327 Sentence denotes The discovery that lung cancer patients that harbor COVID-19 display more severe symptoms (Liang et al., 2020) set out intensive research on the possible connection between malignancies and ACE2 expression.
T443 72328-72445 Sentence denotes A thorough bioinformatics analysis of the TCGA dataset on several kinds of cancer (Chai et al., 2020) has shown that:
T444 72446-72514 Sentence denotes (1) Mutation and amplification of ACE2 gene are frequent in cancer.
T445 72515-72620 Sentence denotes Yet, hot-spot mutation sites were never observed, as ACE2 mutations were distributed across all 18 exons.
T446 72621-72877 Sentence denotes (2) ACE2 transcription was upregulated in six tumors: colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and lung adenocarcinoma (LUAD).
T447 72878-72965 Sentence denotes Interestingly, ACE2 transcription was unchanged in lung squamous cell carcinoma (LUSC).
T448 72966-73110 Sentence denotes (3) ACE2 transcription was downregulated in three tumors: testicular germ cell (TGCT), thyroid carcinoma (THCA), and kidney chromophobe (KICH).
T449 73111-73266 Sentence denotes (4) Changes of ACE2 transcription were epigenetic in nature, as both mutation and copy variation of ACE2 did not correlate with its up- or downregulation.
T450 73267-73371 Sentence denotes (5) In most cases, changes of ACE2 transcription strongly correlated with methylation in ACE2 promoter.
T451 73372-73502 Sentence denotes More specifically, decreased methylation levels correlated with upregulation, whereas increased methylation led to downregulation.
T452 73503-73590 Sentence denotes (6) No prognostic role of ACE2 expression on patient’s survival could be demonstrated.
T453 73591-73711 Sentence denotes These data confirm the remarkable role of methylation in determining the ACE2 expression, as described in paragraph 2.2.
T454 73712-74057 Sentence denotes Interestingly, a second bioinformatics study on Oncomine and TCGA databases gave slightly different results in terms of tumor-associated ACE2 expression changes, but confirmed the role of promoter hypomethylation in KIRP and uterine corpus endometrial carcinoma (UCEC) where ACE2 transcription was significantly upregulated (Yang et al., 2020a).
T455 74059-74069 Sentence denotes Conclusion
T456 74070-74193 Sentence denotes From the structural point of view ACE2 is closely related to ACE, and its discovery was a by-product of ACE investigations.
T457 74194-74308 Sentence denotes However, this macromolecule has soon showed peculiar functional properties and has attracted increasing attention.
T458 74309-74560 Sentence denotes The expression of ACE2 in the heart, kidney and vascular system pointed to a role in the regulation of blood pressure and cardiovascular homeostasis, possibly as a counterbalance to ACE activation, but this hypothesis now appears to be too simplistic.
T459 74561-74759 Sentence denotes Additional functions of ACE2 are strongly suggested by its capability to modulate cytokine metabolism and the inflammatory reaction, as well as by its remarkable expression in the respiratory tract.
T460 74760-74970 Sentence denotes The recent COVID-19 pandemic has put ACE2 in the spotlight, since it has been identified as the initial target of the SARS-Cov and SARS-Cov2 viruses, representing the receptor responsible for cellular adhesion.
T461 74971-75204 Sentence denotes Recent investigations have clarified the molecular details of the interaction of ACE2 with the spike glycoprotein present in this class of coronaviruses, and have partly unraveled the mechanism of protein cleavage and cellular entry.
T462 75205-75503 Sentence denotes ACE2 density on cell surface and ACE2-modulated inflammatory reactions have been suggested to be important determinants of COVID-19 susceptibility and clinical course, while drugs interfering with ACE2 expression, availability and processing are under investigation as potential therapeutic agents.
T463 75504-75710 Sentence denotes However, several crucial issues concerning the link between ACE2 and COVID-19 pathophysiology are still unclear, pointing to the need for focused experimental investigations and prospective clinical trials.
T464 75712-75732 Sentence denotes Author Contributions
T465 75733-75835 Sentence denotes FS, GR, SS, LB, BS, and RB wrote the first draft of the manuscript and prepared the table and figures.
T466 75836-75871 Sentence denotes RZ revised and integrated the text.
T467 75872-75931 Sentence denotes All authors decided upon the general outline of the review.
T468 75933-75953 Sentence denotes Conflict of Interest
T469 75954-76126 Sentence denotes The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T6 451-456 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T7 1629-1633 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T8 3417-3422 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T9 4435-4440 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T10 4581-4586 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T11 4899-4904 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T12 4916-4922 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T13 5173-5179 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T14 8608-8614 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T15 8962-8968 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T16 9072-9078 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T17 9225-9229 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T18 9525-9531 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T19 9623-9647 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T20 10163-10169 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T21 12251-12255 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T22 12299-12303 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T23 12745-12749 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 12830-12834 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 12835-12841 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T26 13185-13189 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T27 13203-13209 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T28 14070-14075 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T29 15777-15783 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T30 15983-16004 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T31 16009-16015 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T32 16218-16229 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T33 16325-16336 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T34 16400-16407 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T35 16466-16472 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T36 16502-16518 Body_part denotes coronary vessels http://purl.obolibrary.org/obo/UBERON_0005985
T37 16593-16597 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T38 16672-16678 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T39 16679-16700 Body_part denotes interlobular arteries http://purl.obolibrary.org/obo/UBERON_0004723
T40 16765-16770 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T41 16826-16835 Body_part denotes mesangium http://purl.obolibrary.org/obo/UBERON_0002319
T42 16840-16862 Body_part denotes glomerular endothelium http://purl.obolibrary.org/obo/UBERON_0004189
T43 16870-16876 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T44 16912-16921 Body_part denotes sinusoids http://purl.obolibrary.org/obo/UBERON_0003909
T45 16929-16934 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T46 17086-17092 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T47 17100-17106 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T48 17108-17119 Body_part denotes lymph nodes http://purl.obolibrary.org/obo/UBERON_0000029
T49 17125-17136 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T50 17182-17187 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T51 17382-17387 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T52 17565-17580 Body_part denotes sinoatrial node http://purl.obolibrary.org/obo/UBERON_0002351
T53 17680-17685 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T54 17749-17762 Body_part denotes aortic valves http://purl.obolibrary.org/obo/UBERON_0002137
T55 17953-17959 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T56 18312-18326 Body_part denotes distal tubules http://purl.obolibrary.org/obo/UBERON_0004135
T57 18343-18347 Body_part denotes duct http://purl.obolibrary.org/obo/UBERON_0000058
T58 18498-18515 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T59 18617-18623 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T60 18632-18638 Body_part denotes larynx http://purl.obolibrary.org/obo/UBERON_0001737
T61 18640-18647 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T62 18649-18656 Body_part denotes bronchi http://purl.obolibrary.org/obo/UBERON_0002185
T63 18661-18665 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T64 18731-18746 Body_part denotes oral epithelium http://purl.obolibrary.org/obo/UBERON_0002424
T65 18895-18899 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T66 19150-19173 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T67 19221-19235 Body_part denotes lamina propria http://purl.obolibrary.org/obo/UBERON_0000030
T68 19278-19283 Body_part denotes gland http://purl.obolibrary.org/obo/UBERON_0002530
T69 19284-19288 Body_part denotes duct http://purl.obolibrary.org/obo/UBERON_0000058
T70 19289-19299 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T71 19308-19312 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T72 19830-19835 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T73 19874-19880 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T74 19881-19892 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T75 19911-19920 Body_part denotes bile duct http://purl.obolibrary.org/obo/UBERON_0002394
T76 20150-20165 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T77 20181-20189 Body_part denotes duodenum http://purl.obolibrary.org/obo/UBERON_0002114
T78 20191-20198 Body_part denotes jejunum http://purl.obolibrary.org/obo/UBERON_0002115
T79 20204-20209 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T80 20241-20246 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T81 20254-20260 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T82 20268-20283 Body_part denotes digestive tract http://purl.obolibrary.org/obo/UBERON_0001555
T83 20297-20304 Body_part denotes stomach http://purl.obolibrary.org/obo/UBERON_0000945
T84 20309-20314 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T85 20535-20541 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T86 20563-20583 Body_part denotes islets of Langerhans http://purl.obolibrary.org/obo/UBERON_0000006
T87 20670-20675 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T88 20686-20699 Body_part denotes telencephalon http://purl.obolibrary.org/obo/UBERON_0001893
T89 20746-20751 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T90 20852-20857 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T91 20861-20867 Body_part denotes lamina http://purl.obolibrary.org/obo/UBERON_0000957
T92 20880-20897 Body_part denotes subfornical organ http://purl.obolibrary.org/obo/UBERON_0002219
T93 20966-20979 Body_part denotes area postrema http://purl.obolibrary.org/obo/UBERON_0002162
T94 20981-21010 Body_part denotes nucleus of the solitary tract http://purl.obolibrary.org/obo/UBERON_0009050
T95 21070-21099 Body_part denotes rostral ventrolateral medulla http://purl.obolibrary.org/obo/UBERON_0005807
T96 21181-21186 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T97 21256-21271 Body_part denotes piriform cortex http://purl.obolibrary.org/obo/UBERON_0004725
T98 21286-21301 Body_part denotes caudate putamen http://purl.obolibrary.org/obo/UBERON_0005383
T99 21303-21322 Body_part denotes hypoglossal nucleus http://purl.obolibrary.org/obo/UBERON_0002871
T100 21327-21347 Body_part denotes primary motor cortex http://purl.obolibrary.org/obo/UBERON_0001384
T101 21590-21596 Body_part denotes retina http://purl.obolibrary.org/obo/UBERON_0000966
T102 21735-21751 Body_part denotes endocrine system http://purl.obolibrary.org/obo/UBERON_0000949
T103 21796-21823 Body_part denotes female reproductive systems http://purl.obolibrary.org/obo/UBERON_0000474
T104 21834-21840 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T105 22079-22085 Body_part denotes stroma http://purl.obolibrary.org/obo/UBERON_0003891
T106 22459-22463 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T107 22495-22505 Body_part denotes cell layer http://purl.obolibrary.org/obo/UBERON_0000119
T108 22546-22556 Body_part denotes cell layer http://purl.obolibrary.org/obo/UBERON_0000119
T109 22560-22574 Body_part denotes hair follicles http://purl.obolibrary.org/obo/UBERON_0002073
T110 22612-22628 Body_part denotes sebaceous glands http://purl.obolibrary.org/obo/UBERON_0001821
T111 22700-22715 Body_part denotes sebaceous gland http://purl.obolibrary.org/obo/UBERON_0001821
T112 22896-22902 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T113 22929-22943 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T114 23187-23192 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T115 23197-23203 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T116 23271-23277 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T117 24037-24042 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T118 24961-24967 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T119 24979-24984 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T120 24986-24993 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T121 26791-26804 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T122 27433-27438 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T123 28121-28125 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T124 28224-28231 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T125 28297-28300 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T126 28343-28347 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T127 28438-28442 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T128 28649-28653 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T129 28994-29000 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T130 29015-29019 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T131 29331-29335 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T132 30008-30012 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T133 31578-31584 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T134 32886-32891 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T135 37845-37850 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T136 38106-38111 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T137 38448-38452 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T138 39484-39488 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T139 45740-45753 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T140 52978-52984 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T141 53190-53195 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T142 55229-55233 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T143 57995-57999 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T144 59874-59887 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T145 61416-61421 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T146 63548-63554 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T147 64152-64165 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T148 66201-66205 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T149 67703-67707 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T150 68324-68328 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T151 69238-69250 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T152 69271-69277 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T153 69745-69749 Body_part denotes nose http://purl.obolibrary.org/obo/UBERON_0000004
T154 70321-70327 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T155 70751-70759 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264
T156 70923-70937 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T157 70974-70979 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T158 71347-71353 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T159 71432-71437 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T160 71826-71830 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T161 72140-72144 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T162 72676-72681 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T163 72705-72711 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T164 72785-72791 Body_part denotes rectum http://purl.obolibrary.org/obo/UBERON_0001052
T165 72815-72822 Body_part denotes stomach http://purl.obolibrary.org/obo/UBERON_0000945
T166 72850-72854 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T167 72929-72933 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T168 73054-73061 Body_part denotes thyroid http://purl.obolibrary.org/obo/UBERON_0002046
T169 73084-73090 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T170 73945-73951 Body_part denotes corpus http://purl.obolibrary.org/obo/UBERON_3000645
T171 74339-74344 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T172 74346-74352 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T173 74357-74372 Body_part denotes vascular system http://purl.obolibrary.org/obo/UBERON_0007798
T174 74412-74417 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T175 74741-74758 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
199 3301-3311 Gene denotes bradykinin Gene:3827
1992 70169-70173 Gene denotes ACE2 Gene:59272
1993 70265-70269 Gene denotes ACE2 Gene:59272
1994 70307-70317 Gene denotes collectrin Gene:57393
1080 36145-36149 Gene denotes ACE2 Gene:59272
1081 35380-35388 Species denotes SARS-CoV Tax:694009
100 162-175 Gene denotes angiotensin I Gene:183
101 180-190 Gene denotes bradykinin Gene:3827
1014 32754-32759 Gene denotes spike Gene:43740568
1015 32779-32787 Gene denotes membrane Gene:43740571
1016 32765-32773 Gene denotes envelope Gene:43740570
1017 33711-33712 Gene denotes S Gene:43740568
1018 33410-33411 Gene denotes S Gene:43740568
1019 33342-33343 Gene denotes S Gene:43740568
102 238-241 Gene denotes ACE Gene:1636
1020 33194-33202 Gene denotes membrane Gene:43740571
1021 32700-32711 Species denotes coronavirus Tax:11118
1022 33331-33341 Species denotes SARS-CoV-2 Tax:2697049
1023 33415-33420 Species denotes human Tax:9606
1024 33421-33429 Species denotes SARS-CoV Tax:694009
1025 33494-33504 Species denotes SARS-CoV-2 Tax:2697049
1026 33548-33556 Species denotes SARS-CoV Tax:694009
1027 33686-33694 Species denotes SARS-CoV Tax:694009
1028 33700-33710 Species denotes SARS-CoV-2 Tax:2697049
1029 33787-33795 Species denotes SARS-CoV Tax:694009
103 342-345 Gene denotes ACE Gene:1636
1030 33799-33809 Species denotes SARS-CoV-2 Tax:2697049
1031 33030-33046 Chemical denotes N-linked glycans
1035 33893-33904 Species denotes Coronavirus Tax:11118
1036 33972-33980 Species denotes SARS-CoV Tax:694009
1037 33985-33995 Species denotes SARS-CoV-2 Tax:2697049
104 478-481 Gene denotes ACE Gene:1636
1048 34224-34232 Gene denotes envelope Gene:43740570
1049 34001-34002 Gene denotes S Gene:43740568
105 377-399 Disease denotes cardiovascular disease MESH:D002318
1050 47842-47849 Gene denotes mmodate Gene:43740571
1051 47497-47507 Gene denotes data conve Gene:43740571
1052 34510-34518 Species denotes SARS-CoV Tax:694009
1053 36356-36366 Species denotes SARS-CoV-2 Tax:2697049
1054 34132-34134 Gene denotes aa Gene:351
1055 34093-34095 Gene denotes aa Gene:351
1056 47374-47397 Chemical denotes g et al., 2020b; Wang e MESH:D005998
1057 47423-47429 Chemical denotes alls e MESH:D000409
106 423-435 Disease denotes hypertension MESH:D006973
107 440-464 Disease denotes congestive heart failure MESH:D006333
1076 35508-35512 Gene denotes ACE2 Gene:59272
1077 35658-35662 Gene denotes ACE2 Gene:70008
1078 35848-35852 Gene denotes ACE2 Gene:59272
1079 35941-35946 Gene denotes hDPP4 Gene:1803
1082 35393-35403 Species denotes SARS-CoV-2 Tax:2697049
1083 35615-35620 Species denotes human Tax:9606
1084 35638-35641 Species denotes pig Tax:9823
1085 35651-35656 Species denotes mouse Tax:10090
1086 35815-35825 Species denotes SARS-CoV-2 Tax:2697049
1087 35829-35837 Species denotes SARS-CoV Tax:694009
1088 35905-35910 Species denotes human Tax:9606
1089 35935-35939 Species denotes CoVs Tax:11118
1090 35964-35972 Species denotes MERS CoV Tax:1335626
1091 35977-35986 Species denotes HCoV-229E Tax:11137
1092 36126-36136 Species denotes SARS-CoV-2 Tax:2697049
1093 35791-35799 Disease denotes infected MESH:D007239
1097 36238-36246 Gene denotes membrane Gene:43740571
1098 36343-36351 Species denotes SARS-CoV Tax:694009
1099 36356-36366 Species denotes SARS-CoV-2 Tax:2697049
1109 37068-37069 Gene denotes S Gene:43740568
1110 36575-36576 Gene denotes S Gene:43740568
1111 38142-38146 Gene denotes post Gene:159371
1112 37640-37644 Gene denotes post Gene:159371
1113 38013-38021 Gene denotes membrane Gene:43740571
1114 36777-36785 Gene denotes membrane Gene:43740571
1115 36427-36435 Species denotes SARS-CoV Tax:694009
1116 36440-36450 Species denotes SARS-CoV-2 Tax:2697049
1117 37839-37841 Gene denotes aa Gene:351
1127 39341-39342 Gene denotes S Gene:43740568
1128 38741-38742 Gene denotes S Gene:43740568
1129 38687-38688 Gene denotes S Gene:43740568
1130 39307-39311 Gene denotes post Gene:159371
1131 39583-39591 Gene denotes membrane Gene:43740571
1132 39545-39553 Gene denotes membrane Gene:43740571
1133 39516-39524 Gene denotes membrane Gene:43740571
1134 39115-39123 Gene denotes membrane Gene:43740571
1135 38632-38643 Species denotes Coronavirus Tax:11118
1139 39922-39925 Gene denotes PDB Gene:5131
1140 39675-39676 Gene denotes S Gene:43740568
1141 39688-39698 Species denotes SARS-CoV-2 Tax:2697049
1163 39968-39972 Gene denotes ACE2 Gene:59272
1164 40813-40818 Gene denotes furin Gene:5045
1165 40895-40902 Gene denotes TMPRSS2 Gene:7113
1166 41050-41061 Gene denotes cathepsin L Gene:1514
1167 40369-40374 Gene denotes furin Gene:5045
1168 40605-40610 Gene denotes furin Gene:5045
1169 40540-40541 Gene denotes S Gene:43740568
1170 39986-39987 Gene denotes S Gene:43740568
1171 41377-41385 Gene denotes membrane Gene:43740571
1172 41324-41332 Gene denotes membrane Gene:43740571
1173 40937-40945 Gene denotes membrane Gene:43740571
1174 40069-40079 Species denotes SARS-CoV-2 Tax:2697049
1175 40143-40153 Species denotes SARS-CoV-2 Tax:2697049
1176 40177-40185 Species denotes SARS-CoV Tax:694009
1177 40207-40220 Species denotes coronaviruses Tax:11118
1178 40529-40539 Species denotes SARS-CoV-2 Tax:2697049
1179 40673-40681 Species denotes SARS-CoV Tax:694009
1180 40707-40717 Species denotes SARS-COV-2 Tax:2697049
1181 41159-41169 Species denotes SARS-CoV-2 Tax:2697049
1182 40823-40828 Gene denotes furin Gene:5045
1183 41212-41220 Disease denotes COVID-19 MESH:C000657245
1192 41807-41814 Gene denotes TMPRSS2 Gene:487770
1193 41609-41614 Gene denotes furin Gene:5045
1194 41462-41463 Gene denotes S Gene:43740568
1195 42082-42086 Gene denotes fuse Gene:2522
1196 42103-42111 Gene denotes membrane Gene:43740571
1197 42022-42030 Gene denotes membrane Gene:43740571
1198 41869-41877 Gene denotes membrane Gene:43740571
1199 41782-41790 Gene denotes membrane Gene:43740571
1201 42335-42345 Species denotes SARS-CoV-2 Tax:2697049
1217 42942-42946 Gene denotes ACE2 Gene:59272
1218 43050-43055 Gene denotes hDPP4 Gene:1803
1219 43095-43099 Gene denotes ACE2 Gene:59272
122 597-601 Gene denotes ACE2 Gene:59272
1220 43153-43157 Gene denotes ACE2 Gene:59272
1221 43031-43039 Gene denotes membrane Gene:43740571
1222 42379-42389 Species denotes SARS-CoV-2 Tax:2697049
1223 42394-42402 Species denotes SARS-CoV Tax:694009
1224 42470-42480 Species denotes SARS-CoV-2 Tax:2697049
1225 42511-42519 Species denotes SARS-CoV Tax:694009
1226 42521-42529 Species denotes SARS-CoV Tax:694009
1227 42647-42657 Species denotes SARS-CoV-2 Tax:2697049
1228 42704-42712 Species denotes SARS-CoV Tax:694009
1229 42820-42830 Species denotes SARS-CoV-2 Tax:2697049
123 704-717 Gene denotes angiotensin I Gene:183
1230 42876-42886 Species denotes SARS-CoV-2 Tax:2697049
1231 42976-42979 CellLine denotes HEK CVCL:M624
124 770-773 Gene denotes ACE Gene:1636
1248 43432-43434 Gene denotes β1 Gene:597
1249 43436-43438 Gene denotes β2 Gene:170589
125 859-863 Gene denotes ACE2 Gene:59272
1250 43440-43442 Gene denotes β3 Gene:28883
1251 43444-43446 Gene denotes β4 Gene:28898
1252 43448-43450 Gene denotes β7 Gene:28885
1253 43503-43505 Gene denotes β4 Gene:28898
1254 43582-43585 Gene denotes β2’ Gene:170589
1255 43574-43577 Gene denotes β1’ Gene:597
1256 43562-43564 Gene denotes β6 Gene:28873
1257 43555-43557 Gene denotes β5 Gene:28884
1258 43510-43512 Gene denotes β7 Gene:28885
1259 43207-43217 Species denotes SARS-CoV-2 Tax:2697049
126 897-901 Gene denotes ACE2 Gene:59272
1260 43314-43324 Species denotes SARS-CoV-2 Tax:2697049
1261 43744-43754 Species denotes SARS-COV-2 Tax:2697049
1262 43759-43767 Species denotes SARS-CoV Tax:694009
1263 43624-43633 Chemical denotes disulfide MESH:D004220
127 955-958 Gene denotes ACE Gene:1636
1271 44029-44033 Gene denotes ACE2 Gene:59272
1272 44100-44105 Gene denotes hACE2 Gene:59272
1273 43988-43993 Gene denotes spike Gene:43740568
1274 44332-44335 Gene denotes PDB Gene:5131
1275 44290-44293 Gene denotes PDB Gene:5131
1276 43744-43754 Species denotes SARS-COV-2 Tax:2697049
1277 44131-44141 Species denotes SARS-CoV-2 Tax:2697049
128 994-998 Gene denotes ACE2 Gene:59272
129 1153-1157 Gene denotes ACE2 Gene:59272
130 1294-1298 Gene denotes ACE2 Gene:59272
1301 44417-44421 Gene denotes ACE2 Gene:59272
1302 44736-44740 Gene denotes ACE2 Gene:59272
1303 45005-45009 Gene denotes ACE2 Gene:59272
1304 45237-45241 Gene denotes ACE2 Gene:59272
1305 45396-45400 Gene denotes ACE2 Gene:59272
1306 45919-45923 Gene denotes ACE2 Gene:59272
1307 45498-45499 Gene denotes S Gene:43740568
1308 45444-45445 Gene denotes S Gene:43740568
1309 44592-44593 Gene denotes S Gene:43740568
131 1144-1152 Gene denotes membrane Gene:43740571
1310 44397-44407 Species denotes SARS-CoV-2 Tax:2697049
1311 44494-44504 Species denotes SARS-CoV-2 Tax:2697049
1312 44965-44975 Species denotes SARS-CoV-2 Tax:2697049
1313 45034-45042 Species denotes SARS-CoV Tax:694009
1314 45214-45224 Species denotes SARS-CoV-2 Tax:2697049
1315 45262-45272 Species denotes SARS-CoV-2 Tax:2697049
1316 45296-45304 Species denotes SARS-CoV Tax:694009
1317 45433-45443 Species denotes SARS-CoV-2 Tax:2697049
1318 45560-45570 Species denotes SARS-CoV-2 Tax:2697049
1319 45629-45637 Species denotes SARS-CoV Tax:694009
132 1057-1065 Species denotes SARS-CoV Tax:694009
1320 45807-45817 Species denotes SARS-CoV-2 Tax:2697049
1321 45822-45830 Species denotes SARS-CoV Tax:694009
1322 45866-45876 Species denotes SARS-CoV-2 Tax:2697049
1323 46179-46189 Species denotes SARS-CoV-2 Tax:2697049
1329 46257-46262 Gene denotes spike Gene:43740568
133 1192-1202 Species denotes SARS-CoV-2 Tax:2697049
1330 46264-46265 Gene denotes S Gene:43740568
1331 46300-46304 Gene denotes ACE2 Gene:59272
1332 46279-46280 Gene denotes S Gene:43740568
1333 46246-46256 Species denotes SARS-CoV-2 Tax:2697049
134 563-566 Gene denotes ACE Gene:11421
1344 46391-46392 Gene denotes S Gene:43740568
1345 46351-46352 Gene denotes S Gene:43740568
1346 46344-46350 Species denotes SARS-2 Tax:2697049
1347 46384-46390 Species denotes SARS-2 Tax:2697049
1348 46422-46428 Species denotes SARS-2 Tax:2697049
1349 46472-46478 Species denotes SARS-2 Tax:2697049
135 1244-1252 Disease denotes COVID-19 MESH:C000657245
1350 46525-46531 Species denotes SARS-2 Tax:2697049
1351 46623-46629 Species denotes SARS-2 Tax:2697049
1352 46690-46696 Species denotes SARS-2 Tax:2697049
1353 46575-46596 CellLine denotes SARS-2 S319–529 44.2 CVCL:Z232
1355 46774-46778 Gene denotes ACE2 Gene:59272
1360 46863-46867 Gene denotes ACE2 Gene:59272
1361 47044-47048 Gene denotes ACE2 Gene:59272
1362 46933-46941 Species denotes SARS-CoV Tax:694009
1363 47057-47065 Species denotes SARS-CoV Tax:694009
1404 47307-47311 Gene denotes ACE2 Gene:59272
1405 47763-47767 Gene denotes ACE2 Gene:59272
1406 47828-47832 Gene denotes ACE2 Gene:59272
1407 47981-47985 Gene denotes ACE2 Gene:59272
1408 48003-48007 Gene denotes ACE2 Gene:59272
1409 48202-48206 Gene denotes ACE2 Gene:59272
1410 48644-48646 Gene denotes β5 Gene:28884
1411 48800-48804 Gene denotes ACE2 Gene:59272
1412 49000-49004 Gene denotes ACE2 Gene:59272
1413 49244-49248 Gene denotes ACE2 Gene:59272
1414 49330-49334 Gene denotes ACE2 Gene:59272
1415 49446-49450 Gene denotes ACE2 Gene:59272
1416 49613-49617 Gene denotes ACE2 Gene:59272
1417 49809-49813 Gene denotes ACE2 Gene:59272
1418 48128-48129 Gene denotes S Gene:43740568
1419 47855-47856 Gene denotes S Gene:43740568
1420 47729-47730 Gene denotes S Gene:43740568
1421 47624-47625 Gene denotes S Gene:43740568
1422 48327-48329 Gene denotes β6 Gene:28873
1423 48320-48322 Gene denotes β5 Gene:28884
1424 47236-47246 Species denotes SARS-CoV-2 Tax:2697049
1425 47312-47322 Species denotes SARS-CoV-2 Tax:2697049
1426 47986-47994 Species denotes SARS-CoV Tax:694009
1427 48008-48018 Species denotes SARS-CoV-2 Tax:2697049
1428 48083-48093 Species denotes SARS-CoV-2 Tax:2697049
1429 48153-48161 Species denotes SARS-CoV Tax:694009
1430 48754-48764 Species denotes SARS-CoV-2 Tax:2697049
1431 48769-48777 Species denotes SARS-CoV Tax:694009
1432 48806-48814 Species denotes SARS-CoV Tax:694009
1433 48893-48903 Species denotes SARS-CoV-2 Tax:2697049
1434 49085-49095 Species denotes SARS-CoV-2 Tax:2697049
1435 49462-49472 Species denotes SARS-CoV-2 Tax:2697049
1436 49598-49608 Species denotes SARS-CoV-2 Tax:2697049
1437 48836-48847 Chemical denotes Pro-Pro-Ala MESH:C027789
1438 48874-48889 Chemical denotes Gly-Val-Glu-Gly
1439 49021-49026 Chemical denotes Ser19
144 1549-1553 Gene denotes ACE2 Gene:59272
1440 49031-49036 Chemical denotes Gln24
1441 49075-49081 Chemical denotes Phe486
1442 49235-49240 Chemical denotes Tyr83
1443 49270-49276 Chemical denotes Asn501
145 1669-1673 Gene denotes ACE2 Gene:59272
1454 49877-49889 Gene denotes RBD-receptor
1455 50231-50235 Gene denotes ACE2 Gene:480847
1456 50407-50411 Gene denotes ACE2 Gene:59272
1457 50405-50406 Gene denotes S Gene:43740568
1458 50288-50289 Gene denotes S Gene:43740568
1459 50211-50215 Species denotes cats Tax:9685
146 1689-1693 Gene denotes ACE2 Gene:59272
1460 50220-50224 Species denotes dogs Tax:9615
1461 50277-50287 Species denotes SARS-CoV-2 Tax:2697049
1462 50312-50320 Disease denotes COVID-19 MESH:C000657245
1463 50321-50330 Disease denotes infection MESH:D007239
147 1711-1721 Species denotes SARS-CoV-2 Tax:2697049
148 1374-1386 Disease denotes Hypertension MESH:D006973
1484 50515-50519 Gene denotes ACE2 Gene:59272
1485 50804-50807 Gene denotes ACE Gene:1636
1486 50954-50958 Gene denotes ACE2 Gene:59272
1487 51144-51148 Gene denotes ACE2 Gene:59272
1488 51204-51208 Gene denotes ACE2 Gene:59272
1489 51258-51262 Gene denotes ACE2 Gene:59272
149 1432-1440 Disease denotes COVID-19 MESH:C000657245
1490 50460-50465 Species denotes human Tax:9606
1491 50466-50469 Species denotes CoV Tax:11118
1492 50471-50480 Species denotes hCoV-NL63 Tax:277944
1493 50627-50637 Species denotes SARS-CoV-2 Tax:2697049
1494 50683-50692 Species denotes hCoV-NL63 Tax:277944
1496 50866-50876 Species denotes SARS-CoV-2 Tax:2697049
1497 50901-50905 Species denotes CoVs Tax:11118
1498 51043-51052 Species denotes novel CoV Tax:2697049
1499 51068-51074 Species denotes humans Tax:9606
150 1506-1518 Disease denotes hypertension MESH:D006973
1500 51134-51138 Species denotes CoVs Tax:11118
1501 51194-51197 Species denotes CoV Tax:11118
1502 51301-51311 Species denotes SARS-CoV-2 Tax:2697049
1503 51372-51375 Species denotes CoV Tax:11118
1505 51426-51430 Gene denotes ACE2 Gene:59272
151 1525-1537 Disease denotes hypertensive MESH:D006973
153 1873-1877 Gene denotes ACE2 Gene:59272
1536 51499-51507 Species denotes patients Tax:9606
1537 51957-51965 Species denotes patients Tax:9606
1538 52625-52633 Species denotes patients Tax:9606
1539 53365-53373 Species denotes patients Tax:9606
1540 53404-53414 Species denotes SARS-CoV-2 Tax:2697049
1541 51490-51498 Disease denotes COVID-19 MESH:C000657245
1542 51615-51627 Disease denotes hypertension MESH:D006973
1543 51629-51652 Disease denotes cardiovascular diseases MESH:D002318
1544 51657-51681 Disease denotes type-2 diabetes mellitus MESH:D003924
1545 51948-51956 Disease denotes infected MESH:D007239
1546 52039-52051 Disease denotes hypertension MESH:D006973
1547 52061-52069 Disease denotes diabetes MESH:D003920
1548 52082-52105 Disease denotes cardiovascular diseases MESH:D002318
1549 52255-52267 Disease denotes hypertension MESH:D006973
1550 52277-52299 Disease denotes cardiovascular disease MESH:D002318
1551 52467-52475 Disease denotes COVID-19 MESH:C000657245
1552 52689-52701 Disease denotes hypertension MESH:D006973
1553 52706-52715 Disease denotes mortality MESH:D003643
1554 52803-52815 Disease denotes hypertension MESH:D006973
1555 52823-52831 Disease denotes diabetes MESH:D003920
1556 52843-52865 Disease denotes cardiovascular disease MESH:D002318
1557 52898-52906 Disease denotes Diabetes MESH:D003920
1558 52954-52958 Disease denotes ARDS MESH:D012128
1559 52972-52991 Disease denotes acute kidney injury MESH:D058186
156 2076-2079 Gene denotes ACE Gene:1636
1560 53005-53017 Disease denotes septic shock MESH:D012772
1561 53045-53054 Disease denotes mortality MESH:D003643
1562 53216-53225 Disease denotes mortality MESH:D003643
1563 53309-53317 Disease denotes COVID-19 MESH:C000657245
1564 53336-53343 Disease denotes obesity MESH:D009765
1565 53547-53556 Disease denotes mortality MESH:D003643
157 2091-2095 Gene denotes ACE2 Gene:59272
1571 53816-53820 Gene denotes ACE2 Gene:59272
1572 53977-53981 Gene denotes ACE2 Gene:59272
1573 54111-54121 Species denotes SARS-CoV-2 Tax:2697049
1574 53647-53659 Disease denotes hypertensive MESH:D006973
1575 54019-54037 Disease denotes SARS-CoV infection MESH:C000657245
1581 55086-55089 Gene denotes ACE Gene:1636
1582 54207-54217 Species denotes SARS-CoV-2 Tax:2697049
1583 55137-55145 Species denotes patients Tax:9606
1584 55156-55168 Disease denotes hypertension MESH:D006973
1585 55193-55214 Disease denotes coronavirus infection MESH:D018352
1595 55425-55429 Gene denotes ACE2 Gene:59272
1596 55484-55488 Gene denotes ACE2 Gene:59272
1597 55491-55495 Gene denotes ACE2 Gene:59272
1598 55642-55646 Gene denotes ACE2 Gene:59272
1599 55702-55712 Species denotes SARS-CoV-2 Tax:2697049
1600 55343-55358 Disease denotes viral infection MESH:D001102
1601 55579-55591 Disease denotes hypertension MESH:D006973
1602 55593-55615 Disease denotes cardiovascular disease MESH:D002318
1603 55620-55628 Disease denotes diabetes MESH:D003920
1611 55900-55904 Gene denotes ACE2 Gene:59272
1612 56071-56075 Gene denotes ACE2 Gene:59272
1613 56192-56196 Gene denotes ACE2 Gene:59272
1614 55921-55929 Gene denotes membrane Gene:43740571
1615 55946-55966 Disease denotes SARS-CoV-2 infection MESH:C000657245
1616 56127-56136 Disease denotes infection MESH:D007239
1617 56235-56255 Disease denotes respiratory distress MESH:D012128
1622 56602-56610 Species denotes patients Tax:9606
1623 56616-56624 Disease denotes COVID-19 MESH:C000657245
1624 56629-56641 Disease denotes hypertension MESH:D006973
1625 56730-56739 Disease denotes mortality MESH:D003643
1630 57003-57011 Species denotes patients Tax:9606
1631 57121-57129 Species denotes patients Tax:9606
1632 57017-57025 Disease denotes COVID-19 MESH:C000657245
1633 57135-57143 Disease denotes COVID-19 MESH:C000657245
1645 57425-57429 Gene denotes ACE2 Gene:59272
1646 57454-57458 Gene denotes ACE2 Gene:59272
1647 57587-57591 Gene denotes ACE2 Gene:59272
1648 57626-57630 Gene denotes SIT1 Gene:27240
1649 57382-57387 Species denotes human Tax:9606
1650 57516-57521 Species denotes human Tax:9606
1651 57522-57530 Species denotes patients Tax:9606
1652 57605-57613 Gene denotes membrane Gene:43740571
1653 57358-57378 Disease denotes SARS-CoV-2 infection MESH:C000657245
1654 57668-57676 Disease denotes COVID-19 MESH:C000657245
1655 57716-57728 Disease denotes hypertensive MESH:D006973
1657 57739-57743 Gene denotes ACE2 Gene:59272
167 2112-2141 Gene denotes Angiotensin-converting enzyme Gene:1636
1673 58054-58062 Species denotes patients Tax:9606
1674 58651-58659 Species denotes patients Tax:9606
1675 57820-57836 Disease denotes viral infections MESH:D001102
1676 57838-57845 Disease denotes COVID19 MESH:C000657245
1677 57973-57977 Disease denotes ARDS MESH:D012128
1678 57995-58006 Disease denotes lung injury MESH:D055370
1679 58109-58113 Disease denotes ARDS MESH:D012128
168 2143-2146 Gene denotes ACE Gene:1636
1680 58179-58187 Disease denotes COVID-19 MESH:C000657245
1681 58233-58242 Disease denotes pneumonia MESH:D011014
1682 58272-58292 Disease denotes microvascular damage MESH:D017566
1683 58441-58467 Disease denotes cardiovascular involvement MESH:D002318
1684 58511-58528 Disease denotes myocardial injury MESH:D009202
1685 58533-58545 Disease denotes sudden death MESH:D003645
1686 58575-58584 Disease denotes infection MESH:D007239
1687 58642-58650 Disease denotes COVID-19 MESH:C000657245
169 2318-2321 Gene denotes ACE Gene:1636
170 2323-2327 Gene denotes tACE Gene:6868
1703 59199-59204 Gene denotes IL-1β Gene:3552
1704 59206-59211 Gene denotes IFN-γ Gene:3458
1705 59213-59218 Gene denotes IP-10 Gene:3627
1706 59220-59225 Gene denotes MCP-1 Gene:6347
1707 59227-59231 Gene denotes IL-4 Gene:3565
1708 59237-59242 Gene denotes IL-10 Gene:3586
1709 58951-58959 Species denotes patients Tax:9606
171 2471-2474 Gene denotes ACE Gene:1636
1710 59065-59073 Species denotes patients Tax:9606
1711 59151-59159 Species denotes patients Tax:9606
1712 59263-59269 Species denotes people Tax:9606
1713 59285-59293 Species denotes patients Tax:9606
1714 58896-58905 Disease denotes infection MESH:D007239
1715 59022-59030 Disease denotes COVID-19 MESH:C000657245
1716 59035-59044 Disease denotes pneumonia MESH:D011014
1717 59074-59078 Disease denotes ARDS MESH:D012128
172 2294-2297 Gene denotes ACE Gene:1636
1725 59659-59663 Gene denotes ACE2 Gene:59272
1726 59747-59751 Gene denotes ACE2 Gene:59272
1727 60595-60600 Gene denotes NLRP3 Gene:114548
1728 60763-60772 Gene denotes caspase 1 Gene:834
1729 60537-60545 Gene denotes membrane Gene:43740571
173 2424-2432 Gene denotes membrane Gene:43740571
1730 60141-60153 Disease denotes inflammation MESH:D007249
1731 60881-60893 Disease denotes inflammation MESH:D007249
1734 61020-61024 Gene denotes ACE2 Gene:59272
1735 61089-61099 Species denotes SARS-CoV-2 Tax:2697049
174 2106-2111 Species denotes Human Tax:9606
1746 61225-61230 Gene denotes NLRP3 Gene:114548
1747 61296-61312 Gene denotes IL-1β (Chen et a Gene:3552
1748 61431-61451 Gene denotes IL-1β (Huang C. et a Gene:3552
1749 61335-61343 Species denotes patients Tax:9606
175 2166-2175 Chemical denotes gluzincin
1750 61108-61128 Disease denotes SARS-CoV-2 infection MESH:C000657245
1751 61326-61334 Disease denotes COVID-19 MESH:C000657245
1752 61483-61494 Disease denotes leucopoenia
1753 61499-61510 Disease denotes lymphopenia MESH:D008231
1754 61531-61549 Disease denotes COVID-19 pneumonia MESH:C000657245
1755 61604-61635 Disease denotes lymphocyte injury by pyroptosis MESH:D015451
1771 61737-61740 Gene denotes ACE Gene:1636
1772 61741-61745 Gene denotes ACE2 Gene:59272
1773 61809-61813 Gene denotes ACE2 Gene:59272
1774 62084-62088 Gene denotes AT1R Gene:185
1775 62142-62149 Gene denotes ADAM 17 Gene:6868
1776 62165-62169 Gene denotes TNFα Gene:7124
1777 62186-62190 Gene denotes TACE Gene:6868
1778 62272-62276 Gene denotes EGFR Gene:1956
1779 62282-62286 Gene denotes TNFα Gene:7124
1780 62432-62439 Gene denotes ADAM 17 Gene:6868
1781 62497-62503 Gene denotes IL-6Rα Gene:3570
1782 62515-62519 Gene denotes IL-6 Gene:3569
1783 62520-62525 Gene denotes STAT3 Gene:6774
1784 62834-62849 Gene denotes angiotensinogen Gene:183
1785 61723-61733 Species denotes SARS-CoV-2 Tax:2697049
1803 62952-62956 Gene denotes ACE2 Gene:59272
1804 63041-63045 Gene denotes ACE2 Gene:59272
1805 63171-63175 Gene denotes ACE2 Gene:59272
1806 63295-63302 Gene denotes ADAM 17 Gene:6868
1807 63345-63349 Gene denotes TNFα Gene:7124
1808 63409-63413 Gene denotes ACE2 Gene:59272
1809 63587-63591 Gene denotes ACE2 Gene:59272
1810 63822-63826 Gene denotes ACE2 Gene:59272
1811 63895-63901 Gene denotes ADAM17 Gene:6868
1812 63532-63537 Species denotes human Tax:9606
1813 63581-63586 Species denotes human Tax:9606
1814 63372-63380 Gene denotes membrane Gene:43740571
1815 63621-63646 Chemical denotes phorbol myristate acetate MESH:D013755
1816 63009-63021 Disease denotes inflammation MESH:D007249
1817 63538-63554 Disease denotes embryonic kidney MESH:D007674
1818 63562-63568 CellLine denotes HEK293 CVCL:0045
1819 63593-63601 CellLine denotes HEK-ACE2 CVCL:L310
1829 64049-64053 Gene denotes ACE2 Gene:59272
1830 64195-64199 Gene denotes ACE2 Gene:59272
1831 64337-64342 Gene denotes IL-1β Gene:3552
1832 64398-64402 Gene denotes ACE2 Gene:59272
1833 64565-64569 Gene denotes ACE2 Gene:59272
1834 64647-64653 Gene denotes ADAM17 Gene:6868
1835 64718-64728 Species denotes SARS-CoV-2 Tax:2697049
1836 64126-64141 Disease denotes viral infection MESH:D001102
1837 64609-64624 Disease denotes viral infection MESH:D001102
1849 64886-64896 Species denotes SARS-CoV-2 Tax:2697049
1850 65274-65284 Species denotes SARS-CoV-2 Tax:2697049
1851 65317-65327 Species denotes SARS-CoV-2 Tax:2697049
1852 65690-65700 Species denotes SARS-CoV-2 Tax:2697049
1853 64912-64921 Chemical denotes vitamin D MESH:D014807
1854 65046-65061 Disease denotes hypovitaminosis
1855 65089-65097 Disease denotes COVID-19 MESH:C000657245
1856 65409-65424 Disease denotes hypovitaminosis
1857 65431-65451 Disease denotes pulmonary infections MESH:D012141
1858 65508-65530 Disease denotes respiratory infections MESH:D012141
1859 65715-65724 Disease denotes mortality MESH:D003643
1861 65791-65795 Gene denotes ACE2 Gene:59272
1868 65843-65847 Gene denotes ACE2 Gene:59272
1869 66020-66024 Gene denotes ACE2 Gene:59272
1870 65949-65959 Species denotes SARS-CoV-2 Tax:2697049
1871 65889-65897 Disease denotes COVID-19 MESH:C000657245
1872 66034-66043 Disease denotes infection MESH:D007239
1873 66201-66212 Disease denotes lung injury MESH:D055370
1880 66355-66359 Gene denotes ACE2 Gene:59272
1881 66434-66439 Gene denotes ACE 2 Gene:59272
1882 66495-66499 Gene denotes ACE2 Gene:59272
1883 66541-66550 Gene denotes S-protein Gene:43740568
1884 66428-66433 Species denotes human Tax:9606
1885 66369-66378 Disease denotes infection MESH:D007239
1887 66589-66593 Gene denotes ACE2 Gene:59272
1889 66636-66640 Gene denotes ACE2 Gene:59272
1891 66643-66647 Gene denotes ACE2 Gene:59272
1907 66669-66673 Gene denotes ACE2 Gene:59272
1908 67193-67197 Gene denotes ACE2 Gene:59272
1909 67445-67449 Gene denotes ACE2 Gene:59272
191 2591-2594 Gene denotes ACE Gene:1636
1910 67551-67555 Gene denotes ACE2 Gene:59272
1911 67661-67665 Gene denotes ACE2 Gene:59272
1912 67850-67854 Gene denotes ACE2 Gene:59272
1913 67054-67062 Species denotes SARS-CoV Tax:694009
1914 67276-67284 Species denotes SARS-CoV Tax:694009
1915 67734-67750 Species denotes SARS coronavirus Tax:694009
1916 67486-67495 Gene denotes S-protein Gene:43740568
1917 67141-67179 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine
1918 67181-67185 Chemical denotes NAAE
1919 67512-67516 Chemical denotes NAAE
192 2839-2842 Gene denotes ACE Gene:1636
1920 67697-67714 Disease denotes acute lung injury MESH:D055371
1921 67718-67728 Disease denotes infections MESH:D007239
193 2968-2981 Gene denotes angiotensin I Gene:183
1932 68011-68015 Gene denotes ACE2 Gene:59272
1933 68075-68079 Gene denotes ACE2 Gene:59272
1934 68226-68230 Gene denotes ACE2 Gene:59272
1935 68452-68483 Gene denotes angiotensin-converting enzyme 2 Gene:59272
1936 68129-68139 Species denotes SARS-CoV-2 Tax:2697049
1937 68446-68451 Species denotes human Tax:9606
1938 68496-68504 Species denotes patients Tax:9606
1939 68485-68491 Chemical denotes rhACE2
194 2986-2996 Gene denotes bradykinin Gene:3827
1940 68324-68335 Disease denotes lung injury MESH:D055370
1941 68510-68518 Disease denotes COVID-19 MESH:C000657245
195 3032-3035 Gene denotes ACE Gene:1636
1959 66434-66439 Gene denotes ACE 2 Gene:59272
196 3129-3142 Gene denotes angiotensin I Gene:183
1960 68662-68671 Gene denotes S-protein Gene:43740568
1961 69364-69369 Gene denotes hACE2 Gene:59272
1962 69517-69521 Gene denotes ACE2 Gene:59272
1963 69631-69635 Gene denotes ACE2 Gene:59272
1964 66428-66433 Species denotes human Tax:9606
1965 68825-68833 Species denotes patients Tax:9606
1966 69065-69073 Species denotes patients Tax:9606
2111 73357-73361 Gene denotes ACE2 Gene:59272
2114 73530-73534 Gene denotes ACE2 Gene:59272
1967 69232-69237 Species denotes human Tax:9606
1968 69265-69270 Species denotes human Tax:9606
1969 69426-69436 Species denotes SARS-CoV-2 Tax:2697049
197 3155-3169 Gene denotes angiotensin II Gene:183
1970 69533-69543 Species denotes SARS-CoV-2 Tax:2697049
1971 68959-68965 Chemical denotes rhACE2
1972 69145-69151 Chemical denotes rhACE2
1973 68816-68824 Disease denotes COVID-19 MESH:C000657245
1974 69079-69083 Disease denotes ARDS MESH:D012128
1975 69196-69217 Disease denotes SARS-CoV-2 infections MESH:C000657245
1979 69715-69719 Gene denotes ACE2 Gene:59272
198 3255-3258 Gene denotes ACE Gene:1636
1980 70062-70066 Gene denotes ACE2 Gene:59272
1981 70018-70033 Disease denotes viral infection MESH:D001102
1983 13021-13025 Gene denotes ACE2 Gene:59272
1995 70376-70383 Gene denotes insulin Gene:3630
1996 70430-70434 Gene denotes ACE2 Gene:59272
1997 70536-70540 Gene denotes ACE2 Gene:59272
1998 70605-70619 Species denotes gut microbiome Tax:749906
1999 70461-70478 Disease denotes Hartnup’s disease MESH:D006250
200 3377-3380 Gene denotes ACE Gene:1636
2007 70656-70660 Gene denotes ACE2 Gene:59272
2008 70779-70783 Gene denotes ACE2 Gene:59272
2009 70784-70788 Gene denotes Ang1 Gene:284
201 2682-2705 Chemical denotes angiotensin-aldosterone
2010 70813-70820 Gene denotes insulin Gene:3630
2011 70900-70904 Gene denotes ACE2 Gene:59272
2012 70791-70795 Gene denotes MasR Gene:116511
2013 70723-70742 Disease denotes glucose homeostasis MESH:D044882
2017 71050-71054 Gene denotes ACE2 Gene:59272
2018 71118-71122 Gene denotes ACE2 Gene:59272
2019 71070-71087 Disease denotes Alzheimer disease MESH:D000544
202 2707-2711 Chemical denotes RAAS
203 3444-3448 Chemical denotes salt MESH:D012492
2038 71269-71273 Gene denotes ACE2 Gene:59272
2039 71557-71561 Gene denotes ACE2 Gene:59272
204 2727-2750 Disease denotes cardiovascular diseases MESH:D002318
2040 71624-71628 Gene denotes ACE2 Gene:59272
2041 71739-71743 Gene denotes ACE2 Gene:70008
2042 71910-71914 Gene denotes ACE2 Gene:70008
2043 71942-71952 Gene denotes E-cadherin Gene:999
2044 71996-72004 Gene denotes vimentin Gene:7431
2045 71526-71534 Species denotes patients Tax:9606
2046 71691-71696 Species denotes human Tax:9606
2047 71711-71715 Species denotes mice Tax:10090
2048 71261-71267 Disease denotes cancer MESH:D009369
2049 71295-71301 Disease denotes cancer MESH:D009369
205 3336-3347 Disease denotes hypotensive MESH:D007022
2051 71501-71525 Disease denotes hepatocellular carcinoma MESH:D006528
2052 71754-71759 Disease denotes tumor MESH:D009369
2053 71811-71837 Disease denotes Non-Small Cell Lung Cancer MESH:D002289
2054 71839-71844 Disease denotes NSCLC MESH:D002289
2055 72068-72073 Disease denotes NSCLC MESH:D002289
2062 72311-72315 Gene denotes ACE2 Gene:59272
2063 72152-72160 Species denotes patients Tax:9606
2064 72140-72151 Disease denotes lung cancer MESH:D008175
2065 72173-72181 Disease denotes COVID-19 MESH:C000657245
2066 72294-72306 Disease denotes malignancies MESH:D009369
2067 72403-72409 Disease denotes cancer MESH:D009369
2071 72481-72485 Gene denotes ACE2 Gene:59272
2072 72568-72572 Gene denotes ACE2 Gene:59272
2073 72507-72513 Disease denotes cancer MESH:D009369
2084 72626-72630 Gene denotes ACE2 Gene:59272
2085 72893-72897 Gene denotes ACE2 Gene:59272
2086 72668-72674 Disease denotes tumors MESH:D009369
2087 72676-72696 Disease denotes colon adenocarcinoma MESH:D003110
2088 72705-72742 Disease denotes kidney renal papillary cell carcinoma MESH:C538614
2089 72751-72776 Disease denotes pancreatic adenocarcinoma MESH:D000230
2090 72785-72806 Disease denotes rectum adenocarcinoma MESH:D012004
2091 72815-72837 Disease denotes stomach adenocarcinoma MESH:D000230
2092 72850-72869 Disease denotes lung adenocarcinoma MESH:D000077192
2093 72929-72957 Disease denotes lung squamous cell carcinoma MESH:D002294
2099 72971-72975 Gene denotes ACE2 Gene:59272
2100 73017-73023 Disease denotes tumors MESH:D009369
2101 73054-73071 Disease denotes thyroid carcinoma MESH:D013964
2102 73084-73102 Disease denotes kidney chromophobe MESH:D000238
2103 73104-73108 Disease denotes KICH
2106 73127-73131 Gene denotes ACE2 Gene:59272
2107 73212-73216 Gene denotes ACE2 Gene:59272
2110 73298-73302 Gene denotes ACE2 Gene:59272
2115 73549-73556 Species denotes patient Tax:9606
2122 73664-73668 Gene denotes ACE2 Gene:59272
2123 73849-73853 Gene denotes ACE2 Gene:59272
2124 73987-73991 Gene denotes ACE2 Gene:59272
2125 73760-73768 Chemical denotes Oncomine
2126 73832-73837 Disease denotes tumor MESH:D009369
2127 73952-73973 Disease denotes endometrial carcinoma MESH:D016889
2135 74104-74108 Gene denotes ACE2 Gene:59272
2136 74131-74134 Gene denotes ACE Gene:1636
2137 74174-74177 Gene denotes ACE Gene:1636
2138 74327-74331 Gene denotes ACE2 Gene:59272
2139 74491-74494 Gene denotes ACE Gene:1636
2140 74585-74589 Gene denotes ACE2 Gene:59272
2141 74431-74457 Disease denotes cardiovascular homeostasis MESH:D002318
2154 74797-74801 Gene denotes ACE2 Gene:59272
2155 75052-75056 Gene denotes ACE2 Gene:59272
2156 75205-75209 Gene denotes ACE2 Gene:59272
2157 75238-75242 Gene denotes ACE2 Gene:59272
2158 75402-75406 Gene denotes ACE2 Gene:59272
2159 75564-75568 Gene denotes ACE2 Gene:59272
2160 74878-74886 Species denotes SARS-Cov Tax:694009
2161 74891-74900 Species denotes SARS-Cov2 Tax:2697049
2162 75110-75123 Species denotes coronaviruses Tax:11118
2163 74771-74779 Disease denotes COVID-19 MESH:C000657245
2164 75328-75336 Disease denotes COVID-19 MESH:C000657245
2165 75573-75581 Disease denotes COVID-19 MESH:C000657245
2167 75733-75735 Disease denotes FS MESH:D018223
228 3499-3502 Gene denotes ACE Gene:1636
229 3778-3781 Gene denotes ACE Gene:1636
230 3937-3940 Gene denotes ACE Gene:1636
231 4149-4152 Gene denotes ACE Gene:1636
232 4477-4480 Gene denotes ACE Gene:1636
233 4496-4500 Gene denotes ACE2 Gene:59272
234 4673-4677 Gene denotes ACE2 Gene:59272
235 4750-4753 Gene denotes ACE Gene:1636
236 4781-4784 Gene denotes ACE Gene:1636
237 4786-4790 Gene denotes ACE2 Gene:59272
238 4857-4861 Gene denotes ACE2 Gene:59272
239 4946-4950 Gene denotes ACE2 Gene:59272
240 5027-5031 Gene denotes ACE2 Gene:59272
241 3569-3574 Species denotes human Tax:9606
242 3772-3777 Species denotes human Tax:9606
243 4041-4046 Species denotes human Tax:9606
244 4466-4471 Species denotes human Tax:9606
245 4627-4632 Species denotes woman Tax:9606
246 4214-4223 Chemical denotes glutamate MESH:D018698
247 4047-4055 Disease denotes lymphoma MESH:D008223
248 4435-4448 Disease denotes heart failure MESH:D006333
249 4638-4671 Disease denotes idiopathic dilated cardiomyopathy MESH:C536277
251 5144-5148 Gene denotes ACE2 Gene:59272
260 5226-5230 Gene denotes ACE2 Gene:59272
261 5305-5308 Gene denotes ACE Gene:1636
262 5364-5368 Gene denotes ACE2 Gene:59272
263 5395-5398 Gene denotes ACE Gene:1636
264 5410-5414 Gene denotes ACE2 Gene:59272
265 5484-5488 Gene denotes ACE2 Gene:59272
266 5589-5601 Disease denotes hypertension MESH:D006973
267 5606-5628 Disease denotes cardiovascular disease MESH:D002318
282 5700-5704 Gene denotes ACE2 Gene:59272
283 5849-5852 Gene denotes ACE Gene:1636
284 5857-5861 Gene denotes ACE2 Gene:59272
285 5934-5937 Gene denotes ACE Gene:1636
286 5959-5963 Gene denotes ACE2 Gene:59272
287 6029-6033 Gene denotes ACE2 Gene:59272
288 6064-6077 Gene denotes angiotensin I Gene:183
289 6081-6095 Gene denotes angiotensin II Gene:183
290 6116-6126 Gene denotes bradykinin Gene:3827
291 6138-6142 Gene denotes ACE2 Gene:59272
292 6161-6164 Gene denotes ACE Gene:1636
293 6165-6175 Chemical denotes inhibitors
294 6182-6192 Chemical denotes lisinopril MESH:D017706
295 6197-6206 Chemical denotes captopril MESH:D002216
310 6447-6451 Gene denotes ACE2 Gene:59272
311 6540-6544 Gene denotes ACE2 Gene:59272
312 6696-6700 Gene denotes ACE2 Gene:59272
313 7132-7135 Gene denotes ACE Gene:1636
314 7140-7144 Gene denotes ACE2 Gene:59272
315 7246-7250 Gene denotes ACE2 Gene:59272
316 7343-7346 Gene denotes ACE Gene:1636
317 7377-7381 Gene denotes ACE2 Gene:59272
318 7499-7503 Gene denotes ACE2 Gene:59272
319 7596-7606 Gene denotes collectrin Gene:57393
320 7564-7567 Gene denotes ACE Gene:1636
321 7682-7690 Gene denotes membrane Gene:43740571
322 7333-7339 Chemical denotes Gln281
323 7367-7373 Chemical denotes Arg273
327 7743-7747 Gene denotes ACE2 Gene:59272
328 8092-8095 Gene denotes PDB Gene:5131
329 7800-7810 Gene denotes collectrin Gene:57393
332 8149-8153 Gene denotes Post Gene:159371
333 8123-8127 Gene denotes Post Gene:159371
337 8207-8211 Gene denotes ACE2 Gene:59272
338 8270-8274 Gene denotes ACE2 Gene:59272
339 8554-8558 Gene denotes ACE2 Gene:59272
369 8952-8956 Gene denotes ACE2 Gene:59272
370 9064-9068 Gene denotes ACE2 Gene:59272
371 9202-9206 Gene denotes ACE2 Gene:59272
372 9322-9326 Gene denotes ACE2 Gene:59272
373 9381-9385 Gene denotes ACE2 Gene:59272
374 9475-9479 Gene denotes ACE2 Gene:59272
375 9580-9583 Gene denotes ACE Gene:1636
376 9623-9628 Gene denotes renin Gene:5972
377 9825-9829 Gene denotes ACE2 Gene:59272
378 9853-9856 Gene denotes ACE Gene:1636
379 9922-9949 Gene denotes ERα) (Bukowska et al., 2017 Gene:2099
380 10235-10266 Gene denotes Estrogen Related Receptor alpha Gene:2101
381 10268-10272 Gene denotes ERRα Gene:2101
382 10290-10293 Gene denotes ERα Gene:2099
383 10361-10365 Gene denotes ACE2 Gene:59272
384 10529-10533 Gene denotes ACE2 Gene:59272
385 8772-8777 Species denotes human Tax:9606
386 9512-9517 Species denotes human Tax:9606
387 9959-9962 Gene denotes ERα Gene:2099
388 8881-8894 Chemical denotes 17β-estradiol MESH:D004958
389 8896-8898 Chemical denotes E2 MESH:D004958
390 8922-8929 Chemical denotes steroid MESH:D013256
391 9047-9049 Chemical denotes E2 MESH:D004958
392 9462-9464 Chemical denotes E2 MESH:D004958
393 9891-9893 Chemical denotes E2 MESH:D004958
394 9294-9302 Disease denotes COVID-19 MESH:C000657245
395 9337-9357 Disease denotes SARS-CoV-2 infection MESH:C000657245
396 9390-9398 Disease denotes COVID-19 MESH:C000657245
397 9745-9762 Disease denotes myocardial stress MESH:D000079225
420 10689-10693 Gene denotes ACE2 Gene:59272
421 10766-10770 Gene denotes ACE2 Gene:59272
422 10934-10938 Gene denotes ACE2 Gene:59272
423 10972-10975 Gene denotes K27 Gene:342574
424 11158-11162 Gene denotes PRC1 Gene:9055
425 11329-11333 Gene denotes PRC1 Gene:9055
426 11599-11603 Gene denotes EZH2 Gene:2146
427 11663-11667 Gene denotes ACE2 Gene:59272
428 11688-11692 Gene denotes ACE2 Gene:59272
429 11744-11748 Gene denotes EZH2 Gene:2146
430 11812-11816 Gene denotes EZH2 Gene:2146
491 13997-14001 Gene denotes ACE2 Gene:59272
431 11832-11836 Gene denotes ACE2 Gene:59272
432 11909-11913 Gene denotes EZH2 Gene:2146
433 11989-11993 Gene denotes ACE2 Gene:59272
434 12114-12118 Gene denotes ACE2 Gene:59272
435 12273-12277 Gene denotes ACE2 Gene:59272
436 11707-11712 Species denotes human Tax:9606
437 12006-12011 Species denotes human Tax:9606
438 12051-12053 Chemical denotes H3 MESH:C012616
439 12203-12215 Disease denotes hypertension MESH:D006973
440 12217-12225 Disease denotes diabetes MESH:D003920
441 12231-12263 Disease denotes chronic obstructive lung disease MESH:D029424
461 12402-12406 Gene denotes ACE2 Gene:59272
462 12463-12467 Gene denotes ACE2 Gene:59272
463 12718-12722 Gene denotes ACE2 Gene:59272
464 12931-12935 Gene denotes ACE2 Gene:59272
465 13021-13025 Gene denotes ACE2 Gene:59272
466 13117-13121 Gene denotes ACE2 Gene:59272
467 13290-13294 Gene denotes ACE2 Gene:59272
468 13356-13374 Gene denotes Vitamin D receptor Gene:7421
469 13376-13379 Gene denotes VDR Gene:7421
470 13445-13449 Gene denotes ACE2 Gene:59272
471 13470-13473 Gene denotes VDR Gene:7421
472 13504-13508 Gene denotes ACE2 Gene:59272
473 13610-13614 Gene denotes ACE2 Gene:59272
474 13108-13116 Species denotes children Tax:9606
475 13648-13658 Species denotes Sars-CoV-2 Tax:2697049
476 13277-13286 Chemical denotes Vitamin D MESH:D014807
477 13579-13588 Chemical denotes Vitamin D MESH:D014807
478 12978-12984 Disease denotes tumors MESH:D009369
479 13592-13600 Disease denotes COVID-19 MESH:C000657245
487 13704-13707 Gene denotes ACE Gene:1636
488 13708-13712 Gene denotes ACE2 Gene:59272
489 13910-13914 Gene denotes Brg1 Gene:6597
490 13943-13948 Gene denotes FoxM1 Gene:2305
492 14002-14005 Gene denotes ACE Gene:1636
493 14043-14062 Disease denotes cardiac hypertrophy MESH:D006332
498 14220-14227 Gene denotes miR-421 Gene:693122
499 14242-14246 Gene denotes ACE2 Gene:59272
500 14289-14296 Gene denotes miR-421 Gene:693122
501 14307-14311 Gene denotes ACE2 Gene:59272
521 14485-14489 Gene denotes ACE2 Gene:59272
522 14631-14635 Gene denotes ACE2 Gene:59272
523 14707-14711 Gene denotes ACE2 Gene:59272
524 14816-14820 Gene denotes ACE2 Gene:59272
525 14967-14971 Gene denotes ACE2 Gene:59272
526 15058-15062 Gene denotes ACE2 Gene:59272
527 15114-15120 Gene denotes Ang II Gene:24179
528 15131-15137 Gene denotes ADAM17 Gene:6868
529 15173-15177 Gene denotes ACE2 Gene:59272
530 15279-15283 Gene denotes ACE2 Gene:59272
531 15398-15404 Gene denotes ADAM17 Gene:6868
532 15439-15443 Gene denotes ACE2 Gene:59272
533 15003-15013 Gene denotes calmodulin Gene:801
534 14940-14950 Gene denotes calmodulin Gene:801
535 14498-14502 Gene denotes post Gene:159371
536 14414-14418 Gene denotes post Gene:159371
537 14551-14559 Gene denotes membrane Gene:43740571
538 15477-15487 Species denotes Sars-CoV-2 Tax:2697049
539 15310-15332 Disease denotes myocardial dysfunction MESH:D009202
543 15604-15608 Gene denotes ACE2 Gene:59272
544 15562-15566 Gene denotes post Gene:159371
545 15536-15540 Gene denotes post Gene:159371
548 15706-15710 Gene denotes ACE2 Gene:59272
549 15675-15679 Gene denotes post Gene:159371
561 15830-15834 Gene denotes ACE2 Gene:59272
562 15946-15950 Gene denotes ACE2 Gene:59272
563 16173-16177 Gene denotes ACE2 Gene:59272
564 16482-16486 Gene denotes ACE2 Gene:59272
565 16962-16966 Gene denotes ACE2 Gene:59272
566 17008-17012 Gene denotes ACE2 Gene:59272
567 16151-16152 Gene denotes S Gene:43740568
568 15897-15906 Species denotes mammalian Tax:9606
569 17064-17069 Species denotes human Tax:9606
570 15983-16004 Disease denotes cardiovascular system MESH:D002318
571 17070-17085 Disease denotes hemato-lymphoid MESH:D008224
575 17341-17345 Gene denotes ACE2 Gene:59272
576 17687-17691 Gene denotes ACE2 Gene:59272
577 17674-17679 Species denotes human Tax:9606
581 17879-17883 Gene denotes ACE2 Gene:59272
582 17925-17934 Species denotes mammalian Tax:9606
583 17946-17951 Species denotes human Tax:9606
599 18551-18555 Gene denotes ACE2 Gene:59272
600 18694-18698 Gene denotes ACE2 Gene:59272
601 19122-19126 Gene denotes ACE2 Gene:59272
602 19174-19178 Gene denotes ACE2 Gene:59272
603 19336-19340 Gene denotes ACE2 Gene:70008
604 19723-19726 Gene denotes age Gene:5973
605 19643-19646 Gene denotes age Gene:5973
606 18715-18720 Species denotes human Tax:9606
607 19047-19057 Species denotes SARS-CoV-2 Tax:2697049
608 19439-19444 Species denotes mouse Tax:10090
609 19446-19449 Species denotes rat Tax:10116
610 19456-19462 Species denotes ferret Tax:9669
611 19475-19480 Species denotes human Tax:9606
612 19066-19075 Disease denotes infection MESH:D007239
613 19131-19139 Disease denotes COVID-19 MESH:C000657245
620 19793-19797 Gene denotes ACE2 Gene:59272
621 20058-20062 Gene denotes ACE2 Gene:59272
622 20470-20474 Gene denotes ACE2 Gene:59272
623 20241-20246 Disease denotes colon MESH:D003110
624 20309-20314 Disease denotes colon MESH:D003110
625 20514-20534 Disease denotes endocrine pancreatic MESH:D010195
634 20625-20629 Gene denotes ACE2 Gene:70008
635 20729-20733 Gene denotes ACE2 Gene:70008
636 21407-21411 Gene denotes ACE2 Gene:70008
637 21558-21562 Gene denotes ACE2 Gene:70008
638 20664-20669 Species denotes mouse Tax:10090
639 20686-20699 Disease denotes telencephalon
640 20928-20956 Disease denotes hypothalamic paraventricular MESH:D007027
641 20971-20979 Disease denotes postrema
648 21753-21757 Gene denotes ACE2 Gene:59272
649 21842-21846 Gene denotes ACE2 Gene:59272
650 21989-21993 Gene denotes ACE2 Gene:59272
651 21828-21833 Species denotes human Tax:9606
652 22016-22021 Species denotes human Tax:9606
653 22022-22029 Disease denotes ovaries MESH:D010051
656 22247-22251 Gene denotes ACE2 Gene:59272
657 22378-22383 Species denotes human Tax:9606
666 22465-22469 Gene denotes ACE2 Gene:59272
667 22652-22656 Gene denotes ACE2 Gene:59272
668 22762-22766 Gene denotes ACE2 Gene:59272
669 22830-22834 Gene denotes ACE2 Gene:59272
670 22999-23003 Gene denotes ACE2 Gene:59272
671 22857-22865 Gene denotes membrane Gene:43740571
672 22453-22458 Species denotes human Tax:9606
673 22869-22874 Species denotes human Tax:9606
675 23101-23105 Gene denotes ACE2 Gene:59272
688 23175-23179 Gene denotes ACE2 Gene:59272
689 23294-23298 Gene denotes ACE2 Gene:59272
690 23423-23427 Gene denotes ACE2 Gene:59272
691 23517-23521 Gene denotes ACE2 Gene:59272
692 23539-23542 Gene denotes ACE Gene:1636
693 23591-23605 Gene denotes angiotensin II Gene:183
694 23640-23644 Gene denotes ACE2 Gene:70008
695 23721-23725 Gene denotes ACE2 Gene:70008
696 23899-23902 Gene denotes ACE Gene:1636
697 24005-24009 Gene denotes ACE2 Gene:70008
698 23708-23713 Species denotes mouse Tax:10090
699 23688-23698 Species denotes transgenic Tax:10090
705 24132-24136 Gene denotes ACE2 Gene:59272
706 24250-24254 Gene denotes ACE2 Gene:59272
707 24364-24367 Gene denotes ACE Gene:1636
708 24589-24593 Gene denotes MasR Gene:116511
709 24503-24507 Gene denotes MasR Gene:116511
718 24675-24679 Gene denotes ACE2 Gene:59272
719 24701-24705 Gene denotes ACE2 Gene:59272
720 24764-24770 Gene denotes ANG II Gene:24179
721 24803-24816 Gene denotes angiotensin I Gene:183
722 24894-24897 Gene denotes ACE Gene:1636
723 25003-25007 Gene denotes ACE2 Gene:59272
724 25047-25052 Gene denotes BKB1R Gene:623
725 24916-24920 Gene denotes MasR Gene:116511
737 25164-25168 Gene denotes ACE2 Gene:59272
738 25521-25525 Gene denotes ACE2 Gene:59272
739 26097-26101 Gene denotes ACE2 Gene:59272
740 25176-25180 Gene denotes MasR Gene:116511
741 26146-26151 Species denotes human Tax:9606
742 26163-26171 Species denotes patients Tax:9606
743 25585-25597 Chemical denotes nitric oxide MESH:D009569
744 25832-25854 Disease denotes myocardial hypertrophy MESH:D006332
745 25902-25923 Disease denotes myocardial infarction MESH:D009203
746 26184-26192 Disease denotes ischemic MESH:D007511
747 26196-26218 Disease denotes dilated cardiomyopathy MESH:D002311
760 26298-26302 Gene denotes ACE2 Gene:59272
761 26352-26356 Gene denotes ACE2 Gene:59272
762 26577-26581 Gene denotes ACE2 Gene:59272
763 26744-26748 Gene denotes MrgD Gene:116512
764 26806-26810 Gene denotes MrgD Gene:116512
765 26386-26399 Chemical denotes Angiotensin A
766 26401-26406 Chemical denotes Ang-A
767 26597-26604 Chemical denotes Ala-Ang
768 26625-26635 Chemical denotes alamandine MESH:C581752
769 26861-26871 Chemical denotes alamandine MESH:C581752
770 26845-26856 Disease denotes cardiopathy MESH:C536187
771 26919-26925 Disease denotes sepsis MESH:D018805
777 26956-26959 Gene denotes ACE Gene:1636
778 26961-26965 Gene denotes ACE2 Gene:59272
779 26983-26993 Gene denotes bradykinin Gene:3827
780 27025-27035 Gene denotes bradykinin Gene:3827
781 27113-27135 Gene denotes B1 bradykinin receptor Gene:623
794 27200-27204 Gene denotes ACE2 Gene:59272
795 27227-27238 Gene denotes neurotensin Gene:4922
796 27314-27320 Gene denotes apelin Gene:8862
797 27365-27369 Gene denotes ACE2 Gene:59272
798 27491-27495 Gene denotes ACE2 Gene:59272
799 27619-27623 Gene denotes ACE2 Gene:59272
800 27628-27634 Gene denotes Apelin Gene:8862
801 27524-27530 Gene denotes apelin Gene:8862
802 27240-27251 Chemical denotes dynorphin A
803 27264-27271 Chemical denotes ghrelin MESH:D054439
804 27433-27446 Disease denotes heart failure MESH:D006333
805 27698-27710 Disease denotes hypertension MESH:D006973
811 27797-27801 Gene denotes ACE2 Gene:59272
812 27929-27932 Gene denotes ACE Gene:1636
813 28019-28023 Gene denotes MrgD Gene:116512
814 27996-28000 Gene denotes MasR Gene:116511
815 28008-28018 Chemical denotes Alamandine MESH:C581752
818 28112-28116 Gene denotes ACE2 Gene:59272
819 28121-28132 Disease denotes Lung Injury MESH:D055370
831 28133-28137 Gene denotes ACE2 Gene:59272
832 28292-28296 Gene denotes ACE2 Gene:59272
833 28390-28393 Gene denotes ACE Gene:1636
834 28398-28412 Gene denotes angiotensin II Gene:183
835 28208-28223 Disease denotes pulmonary small MESH:D008171
836 28343-28355 Disease denotes lung disease MESH:D008171
837 28432-28449 Disease denotes acute lung injury MESH:D055371
838 28457-28475 Disease denotes pulmonary fibrosis MESH:D011658
839 28477-28499 Disease denotes pulmonary hypertension MESH:D006976
840 28505-28540 Disease denotes acute respiratory distress syndrome MESH:D012128
841 28542-28546 Disease denotes ARDS MESH:D012128
858 28825-28829 Gene denotes ACE2 Gene:70008
859 29238-29242 Gene denotes ACE2 Gene:70008
860 28728-28735 Species denotes anthrax Tax:1392
861 28771-28775 Species denotes H5N1 Tax:102793
862 28839-28843 Species denotes mice Tax:10090
863 28575-28579 Disease denotes ARDS MESH:D012128
864 28649-28660 Disease denotes lung injury MESH:D055370
865 28689-28695 Disease denotes sepsis MESH:D018805
866 28714-28726 Disease denotes pancreatitis MESH:D010195
867 28740-28756 Disease denotes virus infections MESH:D001102
868 28863-28867 Disease denotes ARDS MESH:D012128
869 28935-28941 Disease denotes sepsis MESH:D018805
870 28960-28964 Disease denotes ARDS MESH:D012128
871 29015-29026 Disease denotes lung oedema MESH:D004487
872 29048-29060 Disease denotes inflammation MESH:D007249
873 29084-29118 Disease denotes impairment of respiratory function MESH:D012131
883 29310-29314 Gene denotes ACE2 Gene:59272
884 29360-29364 Gene denotes MasR Gene:116511
885 29879-29907 Gene denotes transforming growth factor β Gene:7124
886 29909-29915 Gene denotes TGF- β Gene:7039
887 29331-29348 Disease denotes lung inflammation MESH:D011014
888 29420-29435 Disease denotes allergic asthma MESH:D001249
889 29484-29496 Disease denotes inflammation MESH:D007249
890 29498-29506 Disease denotes fibrosis MESH:D005355
891 29680-29686 Disease denotes asthma MESH:D001249
900 29983-29987 Gene denotes ACE2 Gene:59272
901 30050-30055 Gene denotes BKB1R Gene:623
902 30081-30085 Gene denotes ACE2 Gene:70008
903 30201-30206 Gene denotes CXCL5 Gene:20311
904 30208-30212 Gene denotes MIP2 Gene:20310
905 30222-30227 Gene denotes TNF-α Gene:21926
906 30098-30103 Species denotes mouse Tax:10090
907 30008-30025 Disease denotes lung inflammation MESH:D011014
923 30292-30295 Gene denotes ACE Gene:1636
924 30296-30300 Gene denotes ACE2 Gene:59272
925 30392-30395 Gene denotes ACE Gene:1636
926 30409-30412 Gene denotes ACE Gene:1636
927 30443-30446 Gene denotes ACE Gene:1636
928 30470-30474 Gene denotes ACE2 Gene:59272
929 30601-30615 Gene denotes angiotensin II Gene:183
930 30285-30290 Species denotes human Tax:9606
931 30638-30646 Species denotes patients Tax:9606
932 30667-30684 Species denotes influenza viruses Tax:11308
933 30685-30689 Species denotes H5N1 Tax:102793
934 30507-30511 Disease denotes ARDS MESH:D012128
935 30531-30540 Disease denotes mortality MESH:D003643
936 30647-30655 Disease denotes infected MESH:D007239
937 30696-30698 CellLine denotes N9 CVCL:0452
940 9381-9385 Gene denotes ACE2 Gene:59272
941 9390-9398 Disease denotes COVID-19 MESH:C000657245
950 30845-30849 Gene denotes ACE2 Gene:59272
951 31709-31713 Gene denotes ACE2 Gene:59272
952 31318-31319 Gene denotes S Gene:43740568
953 31162-31173 Species denotes coronavirus Tax:11118
954 31191-31199 Species denotes SARS-CoV Tax:694009
955 30887-30916 Disease denotes respiratory infective disease MESH:D012141
956 31533-31584 Disease denotes SARS-CoV efficiently infected African Monkey kidney MESH:C000657245
957 31600-31602 CellLine denotes E6 CVCL:4582
976 32500-32504 Gene denotes ACE2 Gene:59272
977 32627-32631 Gene denotes ACE2 Gene:59272
978 31733-31741 Species denotes SARS-CoV Tax:694009
979 31862-31873 Species denotes coronavirus Tax:11118
98 13-42 Gene denotes Angiotensin-converting enzyme Gene:1636
980 31887-31892 Species denotes human Tax:9606
981 32042-32057 Species denotes new coronavirus Tax:2697049
982 32079-32089 Species denotes SARS-CoV-2 Tax:2697049
983 32123-32131 Species denotes SARS-CoV Tax:694009
984 32264-32274 Species denotes SARS-CoV-2 Tax:2697049
985 32476-32486 Species denotes SARS-CoV-2 Tax:2697049
986 32623-32626 Species denotes CoV Tax:11118
987 31797-31807 Disease denotes infections MESH:D007239
988 31960-31965 Disease denotes fever MESH:D005334
989 31974-31996 Disease denotes respiratory impairment MESH:D012131
99 44-47 Gene denotes ACE Gene:1636
990 32002-32011 Disease denotes pneumonia MESH:D011014
991 32189-32213 Disease denotes COronaVIrus Disease 2019 MESH:C000657245
992 32421-32429 Disease denotes COVID-19 MESH:C000657245
993 32528-32537 Disease denotes infection MESH:D007239
995 16151-16152 Gene denotes S Gene:43740568

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T142 13-42 Protein denotes Angiotensin-converting enzyme https://www.uniprot.org/uniprot/Q9VJV3|https://www.uniprot.org/uniprot/Q9TX66|https://www.uniprot.org/uniprot/Q9NKE4|https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6Q4G4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q27572|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q10715|https://www.uniprot.org/uniprot/Q10714|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/A4V0P3
T174 44-47 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T199 162-175 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T216 180-190 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T253 238-241 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T278 342-345 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T303 478-481 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T328 563-566 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T353 597-601 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T354 704-717 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T371 770-773 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T396 859-863 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T397 897-901 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T398 955-958 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T423 994-998 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T424 1083-1101 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T528 1153-1157 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T529 1294-1298 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T530 1549-1553 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T531 1669-1673 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T532 1689-1693 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T533 1873-1877 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T534 2076-2079 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T559 2091-2095 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T560 2112-2141 Protein denotes Angiotensin-converting enzyme https://www.uniprot.org/uniprot/Q9VJV3|https://www.uniprot.org/uniprot/Q9TX66|https://www.uniprot.org/uniprot/Q9NKE4|https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6Q4G4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q27572|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q10715|https://www.uniprot.org/uniprot/Q10714|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/A4V0P3
T592 2143-2146 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T617 2294-2297 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T642 2318-2321 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T667 2424-2440 Protein denotes membrane protein https://www.uniprot.org/uniprot/Q9WCD1|https://www.uniprot.org/uniprot/Q9QAR9|https://www.uniprot.org/uniprot/Q9PY97|https://www.uniprot.org/uniprot/Q9PWZ0|https://www.uniprot.org/uniprot/Q9JEB4|https://www.uniprot.org/uniprot/Q9J4B3|https://www.uniprot.org/uniprot/Q9J4A6|https://www.uniprot.org/uniprot/Q9J3P3|https://www.uniprot.org/uniprot/Q9J3P2|https://www.uniprot.org/uniprot/Q9J3P1|https://www.uniprot.org/uniprot/Q9J3P0|https://www.uniprot.org/uniprot/Q9J3N9|https://www.uniprot.org/uniprot/Q9J3N8|https://www.uniprot.org/uniprot/Q9IKC7|https://www.uniprot.org/uniprot/Q9DLM9|https://www.uniprot.org/uniprot/Q99AS5|https://www.uniprot.org/uniprot/Q91QS9|https://www.uniprot.org/uniprot/Q91GB7|https://www.uniprot.org/uniprot/Q91AU9|https://www.uniprot.org/uniprot/Q91A23|https://www.uniprot.org/uniprot/Q910E2|https://www.uniprot.org/uniprot/Q8V433|https://www.uniprot.org/uniprot/Q8JSP5|https://www.uniprot.org/uniprot/Q8BB24|https://www.uniprot.org/uniprot/Q7TA12|https://www.uniprot.org/uniprot/Q7T7S6|https://www.uniprot.org/uniprot/Q7T7P6|https://www.uniprot.org/uniprot/Q7T726|https://www.uniprot.org/uniprot/Q7T6S9|https://www.uniprot.org/uniprot/Q7T6S3|https://www.uniprot.org/uniprot/Q7T6S0|https://www.uniprot.org/uniprot/Q7T6R5|https://www.uniprot.org/uniprot/Q7T6R1|https://www.uniprot.org/uniprot/Q7T6Q8|https://www.uniprot.org/uniprot/Q6TNF6|https://www.uniprot.org/uniprot/Q6S8E5|https://www.uniprot.org/uniprot/Q6Q1R9|https://www.uniprot.org/uniprot/Q5MQC7|https://www.uniprot.org/uniprot/Q5I5X5|https://www.uniprot.org/uniprot/Q52PA8|https://www.uniprot.org/uniprot/Q4ZJS7|https://www.uniprot.org/uniprot/Q4U5F8|https://www.uniprot.org/uniprot/Q3T8I9|https://www.uniprot.org/uniprot/Q3LZX9|https://www.uniprot.org/uniprot/Q3I5J2|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q14EA7|https://www.uniprot.org/uniprot/Q0ZME4|https://www.uniprot.org/uniprot/Q0Q4E7|https://www.uniprot.org/uniprot/Q0Q472|https://www.uniprot.org/uniprot/Q0Q463|https://www.uniprot.org/uniprot/Q07504|https://www.uniprot.org/uniprot/Q04565|https://www.uniprot.org/uniprot/Q01455|https://www.uniprot.org/uniprot/Q008X3|https://www.uniprot.org/uniprot/P69705|https://www.uniprot.org/uniprot/P69704|https://www.uniprot.org/uniprot/P69703|https://www.uniprot.org/uniprot/P69607|https://www.uniprot.org/uniprot/P69606|https://www.uniprot.org/uniprot/P69605|https://www.uniprot.org/uniprot/P69604|https://www.uniprot.org/uniprot/P69603|https://www.uniprot.org/uniprot/P69602|https://www.uniprot.org/uniprot/P69601|https://www.uniprot.org/uniprot/P69600|https://www.uniprot.org/uniprot/P69599|https://www.uniprot.org/uniprot/P59771|https://www.uniprot.org/uniprot/P59770|https://www.uniprot.org/uniprot/P59596|https://www.uniprot.org/uniprot/P36359|https://www.uniprot.org/uniprot/P36299|https://www.uniprot.org/uniprot/P33464|https://www.uniprot.org/uniprot/P28991|https://www.uniprot.org/uniprot/P27904|https://www.uniprot.org/uniprot/P26021|https://www.uniprot.org/uniprot/P25878|https://www.uniprot.org/uniprot/P24412|https://www.uniprot.org/uniprot/P24266|https://www.uniprot.org/uniprot/P16629|https://www.uniprot.org/uniprot/P15422|https://www.uniprot.org/uniprot/P12649|https://www.uniprot.org/uniprot/P11222|https://www.uniprot.org/uniprot/P10526|https://www.uniprot.org/uniprot/P0DTC5|https://www.uniprot.org/uniprot/P09175|https://www.uniprot.org/uniprot/P08549|https://www.uniprot.org/uniprot/P05136|https://www.uniprot.org/uniprot/P04327|https://www.uniprot.org/uniprot/P04135|https://www.uniprot.org/uniprot/P03415|https://www.uniprot.org/uniprot/O90305|https://www.uniprot.org/uniprot/K9N7A1|https://www.uniprot.org/uniprot/A3EXG9|https://www.uniprot.org/uniprot/A3EXD6|https://www.uniprot.org/uniprot/A3EXA0|https://www.uniprot.org/uniprot/A0MD35
T764 2471-2474 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T789 2591-2594 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T814 2676-2681 Protein denotes renin https://www.uniprot.org/uniprot/Q9TSZ1|https://www.uniprot.org/uniprot/Q6T5C2|https://www.uniprot.org/uniprot/Q6FI38|https://www.uniprot.org/uniprot/Q6DYE7|https://www.uniprot.org/uniprot/Q6DLW5|https://www.uniprot.org/uniprot/Q6DLS0|https://www.uniprot.org/uniprot/Q63497|https://www.uniprot.org/uniprot/P60016|https://www.uniprot.org/uniprot/P52115|https://www.uniprot.org/uniprot/P08424|https://www.uniprot.org/uniprot/P00797
T825 2682-2693 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T826 2839-2842 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T851 2968-2981 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T868 2986-2996 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T905 3032-3035 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T930 3129-3142 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T947 3155-3169 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T964 3255-3258 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T989 3301-3311 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T1026 3377-3380 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1051 3499-3502 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1076 3778-3781 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1101 3937-3940 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1126 3950-3954 Protein denotes ACEH https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/C7ECU1
T1132 4084-4088 Protein denotes ACEH https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/C7ECU1
T1138 4149-4152 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1163 4477-4480 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1188 4496-4500 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1189 4534-4538 Protein denotes RACE https://www.uniprot.org/uniprot/O93323
T1190 4673-4677 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1191 4750-4753 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1216 4781-4784 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1241 4786-4790 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1242 4857-4861 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1243 4946-4950 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1244 5027-5031 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1245 5144-5148 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1246 5221-5225 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1247 5226-5230 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1248 5305-5308 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1273 5364-5368 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1274 5395-5398 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1299 5410-5414 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1300 5484-5488 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1301 5700-5704 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1302 5849-5852 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1327 5857-5861 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1328 5934-5937 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1353 5959-5963 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1354 6029-6033 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1355 6064-6077 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T1372 6081-6095 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T1389 6116-6126 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T1426 6138-6142 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1427 6161-6164 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1452 6447-6451 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1453 6540-6544 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1454 6696-6700 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1455 7132-7135 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1480 7140-7144 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1481 7246-7250 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1482 7343-7346 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1507 7377-7381 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1508 7499-7503 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1509 7564-7567 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1534 7596-7606 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1
T1542 7743-7747 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1543 7800-7810 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1
T1551 8182-8186 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1552 8207-8211 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1553 8270-8274 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1554 8554-8558 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1555 8952-8956 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1556 9064-9068 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1557 9202-9206 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1558 9322-9326 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1559 9381-9385 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1560 9475-9479 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1561 9580-9583 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1586 9623-9628 Protein denotes renin https://www.uniprot.org/uniprot/Q9TSZ1|https://www.uniprot.org/uniprot/Q6T5C2|https://www.uniprot.org/uniprot/Q6FI38|https://www.uniprot.org/uniprot/Q6DYE7|https://www.uniprot.org/uniprot/Q6DLW5|https://www.uniprot.org/uniprot/Q6DLS0|https://www.uniprot.org/uniprot/Q63497|https://www.uniprot.org/uniprot/P60016|https://www.uniprot.org/uniprot/P52115|https://www.uniprot.org/uniprot/P08424|https://www.uniprot.org/uniprot/P00797
T1597 9629-9640 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T1598 9825-9829 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1599 9853-9856 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1624 9897-9914 Protein denotes Estrogen Receptor https://www.uniprot.org/uniprot/Q9YHZ7|https://www.uniprot.org/uniprot/Q9YHT3|https://www.uniprot.org/uniprot/Q9YH33|https://www.uniprot.org/uniprot/Q9YGE6|https://www.uniprot.org/uniprot/Q9UIS7|https://www.uniprot.org/uniprot/Q9UDZ7|https://www.uniprot.org/uniprot/Q9TV98|https://www.uniprot.org/uniprot/Q9QZJ5|https://www.uniprot.org/uniprot/Q9QZG6|https://www.uniprot.org/uniprot/Q9QY52|https://www.uniprot.org/uniprot/Q9QY51|https://www.uniprot.org/uniprot/Q9PWP6|https://www.uniprot.org/uniprot/Q9PVZ9|https://www.uniprot.org/uniprot/Q9PSZ9|https://www.uniprot.org/uniprot/Q9PSZ8|https://www.uniprot.org/uniprot/Q9NU51|https://www.uniprot.org/uniprot/Q9JJT5|https://www.uniprot.org/uniprot/Q98SM9|https://www.uniprot.org/uniprot/Q95131|https://www.uniprot.org/uniprot/Q91424|https://www.uniprot.org/uniprot/Q91250|https://www.uniprot.org/uniprot/Q6QIS5|https://www.uniprot.org/uniprot/Q6MZQ9|https://www.uniprot.org/uniprot/Q5T5H7|https://www.uniprot.org/uniprot/Q53AD2|https://www.uniprot.org/uniprot/Q29040|https://www.uniprot.org/uniprot/Q14276|https://www.uniprot.org/uniprot/Q13511|https://www.uniprot.org/uniprot/P81559|https://www.uniprot.org/uniprot/P57753|https://www.uniprot.org/uniprot/P57717|https://www.uniprot.org/uniprot/P50242|https://www.uniprot.org/uniprot/P50241|https://www.uniprot.org/uniprot/P50240|https://www.uniprot.org/uniprot/P49886|https://www.uniprot.org/uniprot/P49885|https://www.uniprot.org/uniprot/P49884|https://www.uniprot.org/uniprot/P19785|https://www.uniprot.org/uniprot/P16058|https://www.uniprot.org/uniprot/P06212|https://www.uniprot.org/uniprot/P06211|https://www.uniprot.org/uniprot/P03372|https://www.uniprot.org/uniprot/O42174|https://www.uniprot.org/uniprot/O42132
T1668 9915-9920 Protein denotes alpha https://www.uniprot.org/uniprot/Q66765|https://www.uniprot.org/uniprot/Q66764|https://www.uniprot.org/uniprot/Q2V6G9|https://www.uniprot.org/uniprot/Q155Z9|https://www.uniprot.org/uniprot/P32540|https://www.uniprot.org/uniprot/P17594|https://www.uniprot.org/uniprot/P17593|https://www.uniprot.org/uniprot/P12296|https://www.uniprot.org/uniprot/P03304|https://www.uniprot.org/uniprot/C0MHL9|https://www.uniprot.org/uniprot/B8XTP8
T1679 10235-10266 Protein denotes Estrogen Related Receptor alpha https://www.uniprot.org/uniprot/Q6QMY5|https://www.uniprot.org/uniprot/Q5QJV7|https://www.uniprot.org/uniprot/Q3U110|https://www.uniprot.org/uniprot/Q3MHT1|https://www.uniprot.org/uniprot/Q14514|https://www.uniprot.org/uniprot/P11474|https://www.uniprot.org/uniprot/O08580|https://www.uniprot.org/uniprot/B2RRU9
T1687 10268-10271 Protein denotes ERR https://www.uniprot.org/uniprot/Q09143|https://www.uniprot.org/uniprot/P30824
T1689 10361-10365 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1690 10529-10533 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1691 10689-10693 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1692 10766-10770 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1693 10934-10938 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1694 10972-10975 Protein denotes K27 https://www.uniprot.org/uniprot/Q9Z320|https://www.uniprot.org/uniprot/Q7Z3Y8|https://www.uniprot.org/uniprot/Q6R649|https://www.uniprot.org/uniprot/Q6IFW8|https://www.uniprot.org/uniprot/Q0P5J6
T1699 11663-11667 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1700 11688-11692 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1701 11832-11836 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1702 11989-11993 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1703 12114-12118 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1704 12273-12277 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1705 12402-12406 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1706 12463-12467 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1707 12718-12722 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1708 12931-12935 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1709 13021-13025 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1710 13117-13121 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1711 13290-13294 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1712 13376-13379 Protein denotes VDR https://www.uniprot.org/uniprot/Q95MH5|https://www.uniprot.org/uniprot/Q922X0|https://www.uniprot.org/uniprot/Q5PSV3|https://www.uniprot.org/uniprot/Q28037|https://www.uniprot.org/uniprot/P49701|https://www.uniprot.org/uniprot/P48281|https://www.uniprot.org/uniprot/P13053|https://www.uniprot.org/uniprot/P11473|https://www.uniprot.org/uniprot/O42392|https://www.uniprot.org/uniprot/O13124|https://www.uniprot.org/uniprot/G3V1V9|https://www.uniprot.org/uniprot/B2R5Q1|https://www.uniprot.org/uniprot/A3RGC1
T1725 13445-13449 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1726 13470-13473 Protein denotes VDR https://www.uniprot.org/uniprot/Q95MH5|https://www.uniprot.org/uniprot/Q922X0|https://www.uniprot.org/uniprot/Q5PSV3|https://www.uniprot.org/uniprot/Q28037|https://www.uniprot.org/uniprot/P49701|https://www.uniprot.org/uniprot/P48281|https://www.uniprot.org/uniprot/P13053|https://www.uniprot.org/uniprot/P11473|https://www.uniprot.org/uniprot/O42392|https://www.uniprot.org/uniprot/O13124|https://www.uniprot.org/uniprot/G3V1V9|https://www.uniprot.org/uniprot/B2R5Q1|https://www.uniprot.org/uniprot/A3RGC1
T1739 13504-13508 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1740 13610-13614 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1741 13704-13707 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1766 13708-13712 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1767 13997-14001 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1768 14002-14005 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1793 14242-14246 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1794 14307-14311 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1795 14485-14489 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1796 14604-14610 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T1805 14631-14635 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1806 14707-14711 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1807 14816-14820 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1808 14940-14950 Protein denotes calmodulin https://www.uniprot.org/uniprot/Q90496|https://www.uniprot.org/uniprot/Q8STF0|https://www.uniprot.org/uniprot/Q7T3T2|https://www.uniprot.org/uniprot/Q71UH6|https://www.uniprot.org/uniprot/Q6YNX6|https://www.uniprot.org/uniprot/Q6R520|https://www.uniprot.org/uniprot/Q6PI52|https://www.uniprot.org/uniprot/Q6IT78|https://www.uniprot.org/uniprot/Q61380|https://www.uniprot.org/uniprot/Q61379|https://www.uniprot.org/uniprot/Q5ZIQ6|https://www.uniprot.org/uniprot/Q5RAD2|https://www.uniprot.org/uniprot/Q4V949|https://www.uniprot.org/uniprot/Q2KJE6|https://www.uniprot.org/uniprot/Q08D84|https://www.uniprot.org/uniprot/P99014|https://www.uniprot.org/uniprot/P70667|https://www.uniprot.org/uniprot/P62184|https://www.uniprot.org/uniprot/P62160|https://www.uniprot.org/uniprot/P62157|https://www.uniprot.org/uniprot/P62156|https://www.uniprot.org/uniprot/P62154|https://www.uniprot.org/uniprot/P62152|https://www.uniprot.org/uniprot/P62151|https://www.uniprot.org/uniprot/P62149|https://www.uniprot.org/uniprot/P62145|https://www.uniprot.org/uniprot/P62144|https://www.uniprot.org/uniprot/P21251|https://www.uniprot.org/uniprot/P11121|https://www.uniprot.org/uniprot/P07181|https://www.uniprot.org/uniprot/P05935|https://www.uniprot.org/uniprot/P05934|https://www.uniprot.org/uniprot/P02596|https://www.uniprot.org/uniprot/P02595|https://www.uniprot.org/uniprot/P02594|https://www.uniprot.org/uniprot/P02593|https://www.uniprot.org/uniprot/O97341|https://www.uniprot.org/uniprot/O16305|https://www.uniprot.org/uniprot/O02367|https://www.uniprot.org/uniprot/Q9V3T4|https://www.uniprot.org/uniprot/Q9U6D3|https://www.uniprot.org/uniprot/Q9NDV6|https://www.uniprot.org/uniprot/Q9GRJ1|https://www.uniprot.org/uniprot/Q95NR9|https://www.uniprot.org/uniprot/Q95NI4
T1853 14967-14971 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1854 15003-15013 Protein denotes calmodulin https://www.uniprot.org/uniprot/Q90496|https://www.uniprot.org/uniprot/Q8STF0|https://www.uniprot.org/uniprot/Q7T3T2|https://www.uniprot.org/uniprot/Q71UH6|https://www.uniprot.org/uniprot/Q6YNX6|https://www.uniprot.org/uniprot/Q6R520|https://www.uniprot.org/uniprot/Q6PI52|https://www.uniprot.org/uniprot/Q6IT78|https://www.uniprot.org/uniprot/Q61380|https://www.uniprot.org/uniprot/Q61379|https://www.uniprot.org/uniprot/Q5ZIQ6|https://www.uniprot.org/uniprot/Q5RAD2|https://www.uniprot.org/uniprot/Q4V949|https://www.uniprot.org/uniprot/Q2KJE6|https://www.uniprot.org/uniprot/Q08D84|https://www.uniprot.org/uniprot/P99014|https://www.uniprot.org/uniprot/P70667|https://www.uniprot.org/uniprot/P62184|https://www.uniprot.org/uniprot/P62160|https://www.uniprot.org/uniprot/P62157|https://www.uniprot.org/uniprot/P62156|https://www.uniprot.org/uniprot/P62154|https://www.uniprot.org/uniprot/P62152|https://www.uniprot.org/uniprot/P62151|https://www.uniprot.org/uniprot/P62149|https://www.uniprot.org/uniprot/P62145|https://www.uniprot.org/uniprot/P62144|https://www.uniprot.org/uniprot/P21251|https://www.uniprot.org/uniprot/P11121|https://www.uniprot.org/uniprot/P07181|https://www.uniprot.org/uniprot/P05935|https://www.uniprot.org/uniprot/P05934|https://www.uniprot.org/uniprot/P02596|https://www.uniprot.org/uniprot/P02595|https://www.uniprot.org/uniprot/P02594|https://www.uniprot.org/uniprot/P02593|https://www.uniprot.org/uniprot/O97341|https://www.uniprot.org/uniprot/O16305|https://www.uniprot.org/uniprot/O02367|https://www.uniprot.org/uniprot/Q9V3T4|https://www.uniprot.org/uniprot/Q9U6D3|https://www.uniprot.org/uniprot/Q9NDV6|https://www.uniprot.org/uniprot/Q9GRJ1|https://www.uniprot.org/uniprot/Q95NR9|https://www.uniprot.org/uniprot/Q95NI4
T1899 15058-15062 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1900 15131-15137 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T1909 15173-15177 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1910 15279-15283 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1911 15398-15404 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T1920 15439-15443 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1921 15604-15608 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1922 15706-15710 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1923 15800-15804 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1924 15830-15834 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1925 15946-15950 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1926 16151-16160 Protein denotes S Protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T1959 16173-16177 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1960 16281-16287 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1963 16482-16486 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1964 16738-16744 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1967 16962-16966 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1968 17008-17012 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1969 17341-17345 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1970 17687-17691 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1971 17879-17883 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1972 18551-18555 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1973 18694-18698 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1974 19122-19126 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1975 19174-19178 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1976 19221-19227 Protein denotes lamina https://www.uniprot.org/uniprot/P13648|https://www.uniprot.org/uniprot/P11048
T1978 19336-19340 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1979 19793-19797 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1980 20058-20062 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1981 20470-20474 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1982 20625-20629 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1983 20729-20733 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1984 20861-20867 Protein denotes lamina https://www.uniprot.org/uniprot/P13648|https://www.uniprot.org/uniprot/P11048
T1986 21407-21411 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1987 21558-21562 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1988 21753-21757 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1989 21842-21846 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1990 21989-21993 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1991 22247-22251 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1992 22465-22469 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1993 22576-22582 Protein denotes Smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1996 22652-22656 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1997 22762-22766 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1998 22830-22834 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1999 22999-23003 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2000 23101-23105 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2001 23175-23179 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2002 23294-23298 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2003 23423-23427 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2004 23517-23521 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2005 23539-23542 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2030 23591-23605 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2047 23640-23644 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2048 23721-23725 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2049 23899-23902 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2074 24005-24009 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2075 24132-24136 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2076 24150-24166 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2077 24250-24254 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2078 24272-24285 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2095 24364-24367 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2120 24675-24679 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2121 24701-24705 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2122 24719-24735 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2123 24775-24779 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2133 24803-24816 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2150 24884-24888 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2160 24894-24897 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2185 24899-24903 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2195 25003-25007 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2196 25031-25041 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2233 25164-25168 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2234 25521-25525 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2235 25629-25635 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T2238 26097-26101 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2239 26298-26302 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2240 26352-26356 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2241 26357-26373 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2242 26386-26397 Protein denotes Angiotensin https://www.uniprot.org/uniprot/Q10757
T2243 26577-26581 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2244 26707-26733 Protein denotes G-protein coupled receptor https://www.uniprot.org/uniprot/Q9QJ51|https://www.uniprot.org/uniprot/Q18LE5
T2246 26956-26959 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2271 26961-26965 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2272 26983-26993 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2309 27025-27035 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2346 27047-27066 Protein denotes des-Arg9 bradykinin https://www.uniprot.org/uniprot/P86628
T2347 27056-27066 Protein denotes bradykinin https://www.uniprot.org/uniprot/A0A088MIT0
T2348 27113-27135 Protein denotes B1 bradykinin receptor https://www.uniprot.org/uniprot/Q9Z1F4|https://www.uniprot.org/uniprot/Q9R250|https://www.uniprot.org/uniprot/Q9BDQ5|https://www.uniprot.org/uniprot/Q95L02|https://www.uniprot.org/uniprot/Q95L01|https://www.uniprot.org/uniprot/Q8N0Y8|https://www.uniprot.org/uniprot/Q8HZP3|https://www.uniprot.org/uniprot/Q8HZP2|https://www.uniprot.org/uniprot/Q8HZP1|https://www.uniprot.org/uniprot/Q8HZN9|https://www.uniprot.org/uniprot/Q61125|https://www.uniprot.org/uniprot/Q546S7|https://www.uniprot.org/uniprot/Q3BCU0|https://www.uniprot.org/uniprot/P97583|https://www.uniprot.org/uniprot/P48748|https://www.uniprot.org/uniprot/P46663|https://www.uniprot.org/uniprot/O35782|https://www.uniprot.org/uniprot/A8K7F5
T2366 27200-27204 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2367 27213-27222 Protein denotes apelin-13 https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08
T2373 27227-27238 Protein denotes neurotensin https://www.uniprot.org/uniprot/Q9TS28|https://www.uniprot.org/uniprot/Q9QV80|https://www.uniprot.org/uniprot/Q9D3P9|https://www.uniprot.org/uniprot/Q3ZCG0|https://www.uniprot.org/uniprot/P81796|https://www.uniprot.org/uniprot/P41536|https://www.uniprot.org/uniprot/P32560|https://www.uniprot.org/uniprot/P31745|https://www.uniprot.org/uniprot/P30990|https://www.uniprot.org/uniprot/P20068|https://www.uniprot.org/uniprot/P13724|https://www.uniprot.org/uniprot/P10673|https://www.uniprot.org/uniprot/P01156
T2386 27240-27258 Protein denotes dynorphin A (1–13) https://www.uniprot.org/uniprot/Q95104|https://www.uniprot.org/uniprot/Q63193|https://www.uniprot.org/uniprot/Q60478|https://www.uniprot.org/uniprot/P06300|https://www.uniprot.org/uniprot/P01214|https://www.uniprot.org/uniprot/P01213|https://www.uniprot.org/uniprot/O35417|https://www.uniprot.org/uniprot/A8K0Q3
T2394 27264-27271 Protein denotes ghrelin https://www.uniprot.org/uniprot/Q9WUZ1|https://www.uniprot.org/uniprot/Q9QYH7|https://www.uniprot.org/uniprot/Q9GKY6|https://www.uniprot.org/uniprot/Q9GKY5|https://www.uniprot.org/uniprot/Q9GKY4|https://www.uniprot.org/uniprot/Q9ET69|https://www.uniprot.org/uniprot/Q9EQX0|https://www.uniprot.org/uniprot/Q9BEF8|https://www.uniprot.org/uniprot/Q9BEF7|https://www.uniprot.org/uniprot/Q9BDJ6|https://www.uniprot.org/uniprot/Q9BDG8|https://www.uniprot.org/uniprot/Q90W22|https://www.uniprot.org/uniprot/Q8JFY4|https://www.uniprot.org/uniprot/Q8AUU1|https://www.uniprot.org/uniprot/Q76IQ4|https://www.uniprot.org/uniprot/Q76HE2|https://www.uniprot.org/uniprot/Q6BEG7|https://www.uniprot.org/uniprot/Q6BEG6|https://www.uniprot.org/uniprot/Q6BEG5|https://www.uniprot.org/uniprot/Q2I0G0|https://www.uniprot.org/uniprot/Q0VH85|https://www.uniprot.org/uniprot/A5X8W4|https://www.uniprot.org/uniprot/A0MLS4
T2417 27314-27320 Protein denotes apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2424 27365-27369 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2425 27491-27495 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2426 27524-27530 Protein denotes apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2433 27619-27623 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2434 27628-27634 Protein denotes Apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2441 27797-27801 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2442 27929-27932 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2467 28112-28116 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2468 28133-28137 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2469 28292-28296 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2470 28390-28393 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2495 28398-28412 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2512 28825-28829 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2513 29238-29242 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2514 29310-29314 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2515 29892-29905 Protein denotes growth factor https://www.uniprot.org/uniprot/Q8V307|https://www.uniprot.org/uniprot/Q77PC4|https://www.uniprot.org/uniprot/Q776B5|https://www.uniprot.org/uniprot/Q6RZT5|https://www.uniprot.org/uniprot/P08441|https://www.uniprot.org/uniprot/P08072
T2521 29983-29987 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2522 30034-30044 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2559 30081-30085 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2560 30208-30212 Protein denotes MIP2 https://www.uniprot.org/uniprot/Q5WA60|https://www.uniprot.org/uniprot/P30348|https://www.uniprot.org/uniprot/P10889
T2563 30292-30295 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2588 30296-30300 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2589 30392-30395 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2614 30409-30412 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2639 30443-30446 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2664 30470-30474 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2665 30601-30615 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2682 30807-30811 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2683 30845-30849 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2684 31298-31316 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T2788 31631-31643 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T2873 31709-31713 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2874 32500-32504 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2875 32627-32631 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2876 32688-32697 Protein denotes S Protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T2909 32726-32745 Protein denotes structural proteins https://www.uniprot.org/uniprot/Q6LEG6|https://www.uniprot.org/uniprot/Q04766|https://www.uniprot.org/uniprot/Q04765
T2912 33159-33171 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T2997 33342-33351 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3030 33569-33578 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3063 33954-33968 Protein denotes spike” protein https://www.uniprot.org/uniprot/P31340
T3064 34001-34010 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3097 34607-34610 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3106 34621-34624 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3115 35366-35376 Protein denotes S proteins https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3148 35508-35512 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3149 35658-35662 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3150 35848-35852 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3151 35951-35954 Protein denotes APN https://www.uniprot.org/uniprot/Q9UCE0|https://www.uniprot.org/uniprot/Q9JHP4|https://www.uniprot.org/uniprot/Q99K63|https://www.uniprot.org/uniprot/Q91YH8|https://www.uniprot.org/uniprot/Q8IVH3|https://www.uniprot.org/uniprot/Q8IUK3|https://www.uniprot.org/uniprot/Q6GT90|https://www.uniprot.org/uniprot/Q3MHR1|https://www.uniprot.org/uniprot/Q29242|https://www.uniprot.org/uniprot/Q16728|https://www.uniprot.org/uniprot/Q10737|https://www.uniprot.org/uniprot/P97449|https://www.uniprot.org/uniprot/P91887|https://www.uniprot.org/uniprot/P91885|https://www.uniprot.org/uniprot/P81731|https://www.uniprot.org/uniprot/P79171|https://www.uniprot.org/uniprot/P79143|https://www.uniprot.org/uniprot/P79098|https://www.uniprot.org/uniprot/P15684|https://www.uniprot.org/uniprot/P15541|https://www.uniprot.org/uniprot/P15145|https://www.uniprot.org/uniprot/P15144|https://www.uniprot.org/uniprot/O97783|https://www.uniprot.org/uniprot/F1PCB5
T3175 36145-36149 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3176 36575-36584 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3209 36812-36815 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3218 37052-37055 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3227 37436-37439 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3236 38687-38696 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3269 39062-39070 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T3513 39341-39350 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3546 39675-39684 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3579 39749-39752 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3588 39968-39972 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3589 40360-40368 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T3833 40369-40374 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T3841 40460-40472 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T3926 40605-40610 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T3934 40759-40767 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4178 40813-40818 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4186 40823-40828 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4194 40864-40886 Protein denotes trypsin-like proteases https://www.uniprot.org/uniprot/Q9UBX7|https://www.uniprot.org/uniprot/Q9NS65|https://www.uniprot.org/uniprot/Q8IXD7|https://www.uniprot.org/uniprot/Q0WXX5|https://www.uniprot.org/uniprot/O75837
T4199 41050-41061 Protein denotes cathepsin L https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1
T4221 41279-41287 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4465 41609-41614 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4473 41791-41799 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4717 42064-42072 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4961 42346-42349 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4970 42368-42372 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T4971 42498-42501 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4980 42530-42533 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4989 42569-42578 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5022 42713-42716 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5031 42831-42834 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5040 42942-42946 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5041 42976-42979 Protein denotes HEK https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320
T5044 43095-43099 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5045 43153-43157 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5046 43218-43221 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5055 43325-43328 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5064 43768-43771 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5073 44029-44033 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5074 44142-44145 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5083 44209-44212 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5092 44408-44411 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5101 44417-44421 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5102 44505-44508 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5111 44592-44601 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5144 44611-44614 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5153 44736-44740 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5154 44741-44744 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5163 44976-44979 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5172 45005-45009 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5173 45043-45046 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5182 45237-45241 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5183 45396-45400 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5184 45444-45453 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5217 45571-45574 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5226 45638-45641 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5235 45919-45923 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5236 45957-45960 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5245 46020-46029 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5278 46263-46274 Protein denotes (S) protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5311 46300-46304 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5312 46360-46363 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5334 46400-46403 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5356 46449-46452 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5378 46489-46492 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5387 46502-46505 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5409 46542-46545 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5418 46553-46556 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5440 46598-46601 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5462 46774-46778 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5463 46779-46782 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5472 46863-46867 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5473 46942-46945 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5482 47044-47048 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5483 47066-47069 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5492 47307-47311 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5493 47323-47326 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5502 47624-47633 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5535 47639-47642 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5544 47745-47748 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5553 47763-47767 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5554 47828-47832 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5555 47855-47864 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5588 47981-47985 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5589 47995-47998 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5598 48003-48007 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5599 48019-48022 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5608 48202-48206 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5609 48353-48356 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5618 48800-48804 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5619 49000-49004 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5620 49244-49248 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5621 49330-49334 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5622 49446-49450 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5623 49613-49617 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5624 49809-49813 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5625 49877-49880 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5634 50231-50235 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5635 50288-50297 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5668 50407-50411 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5669 50515-50519 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5670 50724-50727 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5679 50804-50807 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5704 50954-50958 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5705 51144-51148 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5706 51204-51208 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5707 51258-51262 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5708 51426-51430 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5709 53675-53678 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5734 53816-53820 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5735 53977-53981 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5736 55086-55089 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5761 55104-55115 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T5762 55425-55429 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5763 55484-55488 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5764 55491-55495 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5765 55642-55646 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5766 55900-55904 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5767 56071-56075 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5768 56192-56196 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5769 57425-57429 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5770 57454-57458 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5771 57587-57591 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5772 57739-57743 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5773 59213-59218 Protein denotes IP-10 https://www.uniprot.org/uniprot/Q96QJ5|https://www.uniprot.org/uniprot/Q8MIZ1|https://www.uniprot.org/uniprot/Q865F5|https://www.uniprot.org/uniprot/Q6GTC7|https://www.uniprot.org/uniprot/P70538|https://www.uniprot.org/uniprot/P48973|https://www.uniprot.org/uniprot/P17515|https://www.uniprot.org/uniprot/P02778
T5781 59220-59225 Protein denotes MCP-1 https://www.uniprot.org/uniprot/Q9UDF3|https://www.uniprot.org/uniprot/Q9TTQ3|https://www.uniprot.org/uniprot/Q9QYD7|https://www.uniprot.org/uniprot/Q9MYN4|https://www.uniprot.org/uniprot/Q549R5|https://www.uniprot.org/uniprot/Q08782|https://www.uniprot.org/uniprot/P61275|https://www.uniprot.org/uniprot/P61274|https://www.uniprot.org/uniprot/P52203|https://www.uniprot.org/uniprot/P42831|https://www.uniprot.org/uniprot/P28292|https://www.uniprot.org/uniprot/P28291|https://www.uniprot.org/uniprot/P14844|https://www.uniprot.org/uniprot/P13500|https://www.uniprot.org/uniprot/P10148|https://www.uniprot.org/uniprot/B2R4V3|https://www.uniprot.org/uniprot/A9QWP7
T5798 59227-59231 Protein denotes IL-4 https://www.uniprot.org/uniprot/Q9XS58|https://www.uniprot.org/uniprot/Q9MZR8|https://www.uniprot.org/uniprot/Q9GL85|https://www.uniprot.org/uniprot/Q95MZ6|https://www.uniprot.org/uniprot/Q8MKE6|https://www.uniprot.org/uniprot/Q8HYB1|https://www.uniprot.org/uniprot/Q865Y0|https://www.uniprot.org/uniprot/Q865X5|https://www.uniprot.org/uniprot/Q7YS71|https://www.uniprot.org/uniprot/Q6YL20|https://www.uniprot.org/uniprot/Q6NZ77|https://www.uniprot.org/uniprot/Q60440|https://www.uniprot.org/uniprot/Q58M18|https://www.uniprot.org/uniprot/Q3S4V6|https://www.uniprot.org/uniprot/Q2PE74|https://www.uniprot.org/uniprot/Q29054|https://www.uniprot.org/uniprot/Q14630|https://www.uniprot.org/uniprot/Q0MS73|https://www.uniprot.org/uniprot/Q0MS70|https://www.uniprot.org/uniprot/Q04745|https://www.uniprot.org/uniprot/P79339|https://www.uniprot.org/uniprot/P79170|https://www.uniprot.org/uniprot/P79155|https://www.uniprot.org/uniprot/P55030|https://www.uniprot.org/uniprot/P51744|https://www.uniprot.org/uniprot/P51492|https://www.uniprot.org/uniprot/P47966|https://www.uniprot.org/uniprot/P46652|https://www.uniprot.org/uniprot/P42202|https://www.uniprot.org/uniprot/P30368|https://www.uniprot.org/uniprot/P30367|https://www.uniprot.org/uniprot/P20096|https://www.uniprot.org/uniprot/P07750|https://www.uniprot.org/uniprot/P05112|https://www.uniprot.org/uniprot/O77762|https://www.uniprot.org/uniprot/O70330|https://www.uniprot.org/uniprot/O62774|https://www.uniprot.org/uniprot/O46393|https://www.uniprot.org/uniprot/A9QWQ7|https://www.uniprot.org/uniprot/A1E293
T5838 59237-59242 Protein denotes IL-10 https://www.uniprot.org/uniprot/Q9Z1Y5|https://www.uniprot.org/uniprot/Q9TSJ7|https://www.uniprot.org/uniprot/Q9TSJ4|https://www.uniprot.org/uniprot/Q9JHK7|https://www.uniprot.org/uniprot/Q8MKG9|https://www.uniprot.org/uniprot/Q865X4|https://www.uniprot.org/uniprot/Q6A2H5|https://www.uniprot.org/uniprot/Q6A2H4|https://www.uniprot.org/uniprot/Q63263|https://www.uniprot.org/uniprot/Q5Q0V6|https://www.uniprot.org/uniprot/Q2PE73|https://www.uniprot.org/uniprot/Q29408|https://www.uniprot.org/uniprot/Q29055|https://www.uniprot.org/uniprot/Q28374|https://www.uniprot.org/uniprot/Q25BC1|https://www.uniprot.org/uniprot/Q1W5D6|https://www.uniprot.org/uniprot/Q0Z972|https://www.uniprot.org/uniprot/Q0VBJ1|https://www.uniprot.org/uniprot/P79338|https://www.uniprot.org/uniprot/P55029|https://www.uniprot.org/uniprot/P51746|https://www.uniprot.org/uniprot/P51497|https://www.uniprot.org/uniprot/P51496|https://www.uniprot.org/uniprot/P48411|https://www.uniprot.org/uniprot/P47965|https://www.uniprot.org/uniprot/P46651|https://www.uniprot.org/uniprot/P43480|https://www.uniprot.org/uniprot/P29456|https://www.uniprot.org/uniprot/P22301|https://www.uniprot.org/uniprot/P18893|https://www.uniprot.org/uniprot/O97798|https://www.uniprot.org/uniprot/O46673|https://www.uniprot.org/uniprot/A9QWR2|https://www.uniprot.org/uniprot/A2T6Z6
T5872 59659-59663 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5873 59747-59751 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5874 60584-60593 Protein denotes protein 3 https://www.uniprot.org/uniprot/Q9JGT9|https://www.uniprot.org/uniprot/Q98663|https://www.uniprot.org/uniprot/Q8V3T9|https://www.uniprot.org/uniprot/Q6UBL8|https://www.uniprot.org/uniprot/Q6Q1S1|https://www.uniprot.org/uniprot/Q6E0W9|https://www.uniprot.org/uniprot/Q68Y30|https://www.uniprot.org/uniprot/Q5GA88|https://www.uniprot.org/uniprot/Q3LZX0|https://www.uniprot.org/uniprot/Q3I5J4|https://www.uniprot.org/uniprot/Q12988|https://www.uniprot.org/uniprot/Q0Q474|https://www.uniprot.org/uniprot/Q02967|https://www.uniprot.org/uniprot/Q00967|https://www.uniprot.org/uniprot/P09522|https://www.uniprot.org/uniprot/P05398|https://www.uniprot.org/uniprot/P03553|https://www.uniprot.org/uniprot/P03552|https://www.uniprot.org/uniprot/P03551
T5893 60629-60638 Protein denotes a protein https://www.uniprot.org/uniprot/Q38365|https://www.uniprot.org/uniprot/P25244|https://www.uniprot.org/uniprot/P25243|https://www.uniprot.org/uniprot/P15966|https://www.uniprot.org/uniprot/P09676|https://www.uniprot.org/uniprot/P07394|https://www.uniprot.org/uniprot/P03632|https://www.uniprot.org/uniprot/P03610|https://www.uniprot.org/uniprot/O64306
T5902 60639-60646 Protein denotes caspase https://www.uniprot.org/uniprot/Q9VAH1|https://www.uniprot.org/uniprot/O01382
T5904 60667-60670 Protein denotes ASC https://www.uniprot.org/uniprot/P50427|https://www.uniprot.org/uniprot/P15589|https://www.uniprot.org/uniprot/P08842|https://www.uniprot.org/uniprot/B2RA47
T5908 60727-60734 Protein denotes caspase https://www.uniprot.org/uniprot/Q9VAH1|https://www.uniprot.org/uniprot/O01382
T5910 60763-60772 Protein denotes caspase 1 https://www.uniprot.org/uniprot/Q9W1N0|https://www.uniprot.org/uniprot/Q9UCN3|https://www.uniprot.org/uniprot/Q9TV13|https://www.uniprot.org/uniprot/Q9N2I1|https://www.uniprot.org/uniprot/Q9MZV7|https://www.uniprot.org/uniprot/Q9MZV6|https://www.uniprot.org/uniprot/Q6PI75|https://www.uniprot.org/uniprot/Q6GSS3|https://www.uniprot.org/uniprot/Q6DMQ1|https://www.uniprot.org/uniprot/Q53EY6|https://www.uniprot.org/uniprot/P89116|https://www.uniprot.org/uniprot/P43527|https://www.uniprot.org/uniprot/P29466|https://www.uniprot.org/uniprot/P29452|https://www.uniprot.org/uniprot/O02002|https://www.uniprot.org/uniprot/B5MDZ1
T5926 61020-61024 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5927 61737-61740 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5952 61741-61745 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5953 61809-61813 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5954 62106-62117 Protein denotes disintegrin https://www.uniprot.org/uniprot/Q9YI19|https://www.uniprot.org/uniprot/Q9PVK9|https://www.uniprot.org/uniprot/Q9IAX6|https://www.uniprot.org/uniprot/Q7SZE0|https://www.uniprot.org/uniprot/Q7SZD7|https://www.uniprot.org/uniprot/Q7SZD6|https://www.uniprot.org/uniprot/Q5EE07|https://www.uniprot.org/uniprot/P0DMH4|https://www.uniprot.org/uniprot/P0C6E3|https://www.uniprot.org/uniprot/O73795|https://www.uniprot.org/uniprot/E9NW26
T5965 62142-62149 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T5974 62239-62262 Protein denotes epidermal growth factor https://www.uniprot.org/uniprot/Q9GU69|https://www.uniprot.org/uniprot/Q9BEA0|https://www.uniprot.org/uniprot/Q9BDQ0|https://www.uniprot.org/uniprot/Q95ND4|https://www.uniprot.org/uniprot/Q6P9J2|https://www.uniprot.org/uniprot/Q63183|https://www.uniprot.org/uniprot/Q569W5|https://www.uniprot.org/uniprot/Q52LZ6|https://www.uniprot.org/uniprot/Q00968|https://www.uniprot.org/uniprot/P07522|https://www.uniprot.org/uniprot/P01133|https://www.uniprot.org/uniprot/P01132|https://www.uniprot.org/uniprot/O62759|https://www.uniprot.org/uniprot/E9QNX6|https://www.uniprot.org/uniprot/E9PBF0|https://www.uniprot.org/uniprot/E7EVD2|https://www.uniprot.org/uniprot/B4DRK7
T5991 62432-62439 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6000 62515-62519 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T6044 62834-62849 Protein denotes angiotensinogen https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T6061 62952-62956 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6062 63041-63045 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6063 63171-63175 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6064 63295-63302 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6073 63307-63318 Protein denotes disintegrin https://www.uniprot.org/uniprot/Q9YI19|https://www.uniprot.org/uniprot/Q9PVK9|https://www.uniprot.org/uniprot/Q9IAX6|https://www.uniprot.org/uniprot/Q7SZE0|https://www.uniprot.org/uniprot/Q7SZD7|https://www.uniprot.org/uniprot/Q7SZD6|https://www.uniprot.org/uniprot/Q5EE07|https://www.uniprot.org/uniprot/P0DMH4|https://www.uniprot.org/uniprot/P0C6E3|https://www.uniprot.org/uniprot/O73795|https://www.uniprot.org/uniprot/E9NW26
T6084 63409-63413 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6085 63538-63547 Protein denotes embryonic https://www.uniprot.org/uniprot/P02301
T6086 63587-63591 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6087 63593-63596 Protein denotes HEK https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320
T6090 63597-63601 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6091 63822-63826 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6092 63895-63901 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6101 63958-63985 Protein denotes metalloproteinase inhibitor https://www.uniprot.org/uniprot/Q9DGI0|https://www.uniprot.org/uniprot/Q98TC1|https://www.uniprot.org/uniprot/P29695
T6104 64007-64027 Protein denotes protease inhibitor 1 https://www.uniprot.org/uniprot/C1IC50
T6105 64049-64053 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6106 64195-64199 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6107 64398-64402 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6108 64565-64569 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6109 64647-64653 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6118 65791-65795 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6119 65843-65847 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6120 66020-66024 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6121 66355-66359 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6122 66434-66437 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6147 66495-66499 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6148 66541-66550 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6159 66589-66593 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6160 66636-66640 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6161 66643-66647 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6162 66669-66673 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6163 67193-67197 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6164 67445-67449 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6165 67486-67495 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6176 67551-67555 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6177 67661-67665 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6178 67850-67854 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6179 67950-67954 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6180 68011-68015 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6181 68075-68079 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6182 68226-68230 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6183 68452-68483 Protein denotes angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T6198 68562-68565 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6223 68662-68671 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6234 69437-69440 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6243 69517-69521 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6244 69544-69547 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6253 69631-69635 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6254 69715-69719 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6255 70062-70066 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6256 70145-70149 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6257 70169-70173 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6258 70265-70269 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6259 70307-70317 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1
T6267 70376-70383 Protein denotes insulin https://www.uniprot.org/uniprot/Q9W7R2|https://www.uniprot.org/uniprot/Q9W653|https://www.uniprot.org/uniprot/Q9TSJ5|https://www.uniprot.org/uniprot/Q9TQY8|https://www.uniprot.org/uniprot/Q9TQY7|https://www.uniprot.org/uniprot/Q9PRR2|https://www.uniprot.org/uniprot/Q9PRR1|https://www.uniprot.org/uniprot/Q9NDE7|https://www.uniprot.org/uniprot/Q98TA8|https://www.uniprot.org/uniprot/Q91XI3|https://www.uniprot.org/uniprot/Q91479|https://www.uniprot.org/uniprot/Q91478|https://www.uniprot.org/uniprot/Q91477|https://www.uniprot.org/uniprot/Q8WNW6|https://www.uniprot.org/uniprot/Q8HXV2|https://www.uniprot.org/uniprot/Q6YK33|https://www.uniprot.org/uniprot/Q62587|https://www.uniprot.org/uniprot/Q5EEX2|https://www.uniprot.org/uniprot/Q53YX4|https://www.uniprot.org/uniprot/Q504H9|https://www.uniprot.org/uniprot/Q10995|https://www.uniprot.org/uniprot/P81881|https://www.uniprot.org/uniprot/P81423|https://www.uniprot.org/uniprot/P81025|https://www.uniprot.org/uniprot/P69048|https://www.uniprot.org/uniprot/P69047|https://www.uniprot.org/uniprot/P69046|https://www.uniprot.org/uniprot/P69045|https://www.uniprot.org/uniprot/P68992|https://www.uniprot.org/uniprot/P68991|https://www.uniprot.org/uniprot/P68990|https://www.uniprot.org/uniprot/P68989|https://www.uniprot.org/uniprot/P68988|https://www.uniprot.org/uniprot/P68987|https://www.uniprot.org/uniprot/P68245|https://www.uniprot.org/uniprot/P68243|https://www.uniprot.org/uniprot/P67974|https://www.uniprot.org/uniprot/P67973|https://www.uniprot.org/uniprot/P67972|https://www.uniprot.org/uniprot/P67971|https://www.uniprot.org/uniprot/P67970|https://www.uniprot.org/uniprot/P67969|https://www.uniprot.org/uniprot/P67968|https://www.uniprot.org/uniprot/P51463|https://www.uniprot.org/uniprot/P42633|https://www.uniprot.org/uniprot/P41522|https://www.uniprot.org/uniprot/P31887|https://www.uniprot.org/uniprot/P30410|https://www.uniprot.org/uniprot/P30407|https://www.uniprot.org/uniprot/P30406|https://www.uniprot.org/uniprot/P29335|https://www.uniprot.org/uniprot/P23187|https://www.uniprot.org/uniprot/P21563|https://www.uniprot.org/uniprot/P18109|https://www.uniprot.org/uniprot/P17715|https://www.uniprot.org/uniprot/P14806|https://www.uniprot.org/uniprot/P13190|https://www.uniprot.org/uniprot/P12708|https://www.uniprot.org/uniprot/P12705|https://www.uniprot.org/uniprot/P12704|https://www.uniprot.org/uniprot/P12703|https://www.uniprot.org/uniprot/P10604|https://www.uniprot.org/uniprot/P0C236|https://www.uniprot.org/uniprot/P09536|https://www.uniprot.org/uniprot/P09477|https://www.uniprot.org/uniprot/P09476|https://www.uniprot.org/uniprot/P07454|https://www.uniprot.org/uniprot/P07453|https://www.uniprot.org/uniprot/P06306|https://www.uniprot.org/uniprot/P04667|https://www.uniprot.org/uniprot/P01342|https://www.uniprot.org/uniprot/P01341|https://www.uniprot.org/uniprot/P01340|https://www.uniprot.org/uniprot/P01339|https://www.uniprot.org/uniprot/P01336|https://www.uniprot.org/uniprot/P01335|https://www.uniprot.org/uniprot/P01334|https://www.uniprot.org/uniprot/P01333|https://www.uniprot.org/uniprot/P01332|https://www.uniprot.org/uniprot/P01331|https://www.uniprot.org/uniprot/P01330|https://www.uniprot.org/uniprot/P01329|https://www.uniprot.org/uniprot/P01328|https://www.uniprot.org/uniprot/P01327|https://www.uniprot.org/uniprot/P01324|https://www.uniprot.org/uniprot/P01321|https://www.uniprot.org/uniprot/P01320|https://www.uniprot.org/uniprot/P01319|https://www.uniprot.org/uniprot/P01318|https://www.uniprot.org/uniprot/P01317|https://www.uniprot.org/uniprot/P01316|https://www.uniprot.org/uniprot/P01315|https://www.uniprot.org/uniprot/P01314|https://www.uniprot.org/uniprot/P01313|https://www.uniprot.org/uniprot/P01312|https://www.uniprot.org/uniprot/P01311|https://www.uniprot.org/uniprot/P01310|https://www.uniprot.org/uniprot/P01309|https://www.uniprot.org/uniprot/P01308|https://www.uniprot.org/uniprot/O73727|https://www.uniprot.org/uniprot/O42485|https://www.uniprot.org/uniprot/C0HJU0|https://www.uniprot.org/uniprot/C0HJT9|https://www.uniprot.org/uniprot/C0HJI4|https://www.uniprot.org/uniprot/C0HJI1
T6372 70430-70434 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6373 70536-70540 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6374 70656-70660 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6375 70779-70783 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6376 70813-70820 Protein denotes insulin https://www.uniprot.org/uniprot/Q9W7R2|https://www.uniprot.org/uniprot/Q9W653|https://www.uniprot.org/uniprot/Q9TSJ5|https://www.uniprot.org/uniprot/Q9TQY8|https://www.uniprot.org/uniprot/Q9TQY7|https://www.uniprot.org/uniprot/Q9PRR2|https://www.uniprot.org/uniprot/Q9PRR1|https://www.uniprot.org/uniprot/Q9NDE7|https://www.uniprot.org/uniprot/Q98TA8|https://www.uniprot.org/uniprot/Q91XI3|https://www.uniprot.org/uniprot/Q91479|https://www.uniprot.org/uniprot/Q91478|https://www.uniprot.org/uniprot/Q91477|https://www.uniprot.org/uniprot/Q8WNW6|https://www.uniprot.org/uniprot/Q8HXV2|https://www.uniprot.org/uniprot/Q6YK33|https://www.uniprot.org/uniprot/Q62587|https://www.uniprot.org/uniprot/Q5EEX2|https://www.uniprot.org/uniprot/Q53YX4|https://www.uniprot.org/uniprot/Q504H9|https://www.uniprot.org/uniprot/Q10995|https://www.uniprot.org/uniprot/P81881|https://www.uniprot.org/uniprot/P81423|https://www.uniprot.org/uniprot/P81025|https://www.uniprot.org/uniprot/P69048|https://www.uniprot.org/uniprot/P69047|https://www.uniprot.org/uniprot/P69046|https://www.uniprot.org/uniprot/P69045|https://www.uniprot.org/uniprot/P68992|https://www.uniprot.org/uniprot/P68991|https://www.uniprot.org/uniprot/P68990|https://www.uniprot.org/uniprot/P68989|https://www.uniprot.org/uniprot/P68988|https://www.uniprot.org/uniprot/P68987|https://www.uniprot.org/uniprot/P68245|https://www.uniprot.org/uniprot/P68243|https://www.uniprot.org/uniprot/P67974|https://www.uniprot.org/uniprot/P67973|https://www.uniprot.org/uniprot/P67972|https://www.uniprot.org/uniprot/P67971|https://www.uniprot.org/uniprot/P67970|https://www.uniprot.org/uniprot/P67969|https://www.uniprot.org/uniprot/P67968|https://www.uniprot.org/uniprot/P51463|https://www.uniprot.org/uniprot/P42633|https://www.uniprot.org/uniprot/P41522|https://www.uniprot.org/uniprot/P31887|https://www.uniprot.org/uniprot/P30410|https://www.uniprot.org/uniprot/P30407|https://www.uniprot.org/uniprot/P30406|https://www.uniprot.org/uniprot/P29335|https://www.uniprot.org/uniprot/P23187|https://www.uniprot.org/uniprot/P21563|https://www.uniprot.org/uniprot/P18109|https://www.uniprot.org/uniprot/P17715|https://www.uniprot.org/uniprot/P14806|https://www.uniprot.org/uniprot/P13190|https://www.uniprot.org/uniprot/P12708|https://www.uniprot.org/uniprot/P12705|https://www.uniprot.org/uniprot/P12704|https://www.uniprot.org/uniprot/P12703|https://www.uniprot.org/uniprot/P10604|https://www.uniprot.org/uniprot/P0C236|https://www.uniprot.org/uniprot/P09536|https://www.uniprot.org/uniprot/P09477|https://www.uniprot.org/uniprot/P09476|https://www.uniprot.org/uniprot/P07454|https://www.uniprot.org/uniprot/P07453|https://www.uniprot.org/uniprot/P06306|https://www.uniprot.org/uniprot/P04667|https://www.uniprot.org/uniprot/P01342|https://www.uniprot.org/uniprot/P01341|https://www.uniprot.org/uniprot/P01340|https://www.uniprot.org/uniprot/P01339|https://www.uniprot.org/uniprot/P01336|https://www.uniprot.org/uniprot/P01335|https://www.uniprot.org/uniprot/P01334|https://www.uniprot.org/uniprot/P01333|https://www.uniprot.org/uniprot/P01332|https://www.uniprot.org/uniprot/P01331|https://www.uniprot.org/uniprot/P01330|https://www.uniprot.org/uniprot/P01329|https://www.uniprot.org/uniprot/P01328|https://www.uniprot.org/uniprot/P01327|https://www.uniprot.org/uniprot/P01324|https://www.uniprot.org/uniprot/P01321|https://www.uniprot.org/uniprot/P01320|https://www.uniprot.org/uniprot/P01319|https://www.uniprot.org/uniprot/P01318|https://www.uniprot.org/uniprot/P01317|https://www.uniprot.org/uniprot/P01316|https://www.uniprot.org/uniprot/P01315|https://www.uniprot.org/uniprot/P01314|https://www.uniprot.org/uniprot/P01313|https://www.uniprot.org/uniprot/P01312|https://www.uniprot.org/uniprot/P01311|https://www.uniprot.org/uniprot/P01310|https://www.uniprot.org/uniprot/P01309|https://www.uniprot.org/uniprot/P01308|https://www.uniprot.org/uniprot/O73727|https://www.uniprot.org/uniprot/O42485|https://www.uniprot.org/uniprot/C0HJU0|https://www.uniprot.org/uniprot/C0HJT9|https://www.uniprot.org/uniprot/C0HJI4|https://www.uniprot.org/uniprot/C0HJI1
T6481 70900-70904 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6482 71050-71054 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6483 71118-71122 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6484 71137-71141 Protein denotes Beta https://www.uniprot.org/uniprot/Q66765|https://www.uniprot.org/uniprot/Q66764|https://www.uniprot.org/uniprot/Q2V6G9|https://www.uniprot.org/uniprot/Q155Z9|https://www.uniprot.org/uniprot/P32540|https://www.uniprot.org/uniprot/P17594|https://www.uniprot.org/uniprot/P17593|https://www.uniprot.org/uniprot/P12296|https://www.uniprot.org/uniprot/P03304|https://www.uniprot.org/uniprot/C0MHL9|https://www.uniprot.org/uniprot/B8XTP8
T6495 71269-71273 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6496 71557-71561 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6497 71624-71628 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6498 71739-71743 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6499 71910-71914 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6500 71942-71952 Protein denotes E-cadherin https://www.uniprot.org/uniprot/Q9UII8|https://www.uniprot.org/uniprot/Q9R0T4|https://www.uniprot.org/uniprot/Q9JIV9|https://www.uniprot.org/uniprot/Q91709|https://www.uniprot.org/uniprot/Q6R8F2|https://www.uniprot.org/uniprot/Q61377|https://www.uniprot.org/uniprot/Q5RAX1|https://www.uniprot.org/uniprot/Q4PJ14|https://www.uniprot.org/uniprot/Q16194|https://www.uniprot.org/uniprot/Q15855|https://www.uniprot.org/uniprot/Q14216|https://www.uniprot.org/uniprot/Q13799|https://www.uniprot.org/uniprot/P30944|https://www.uniprot.org/uniprot/P12830|https://www.uniprot.org/uniprot/P09803|https://www.uniprot.org/uniprot/P08641|https://www.uniprot.org/uniprot/O35794|https://www.uniprot.org/uniprot/F1PAA9|https://www.uniprot.org/uniprot/A8K1U7
T6519 71996-72004 Protein denotes vimentin https://www.uniprot.org/uniprot/Q9NTM3|https://www.uniprot.org/uniprot/Q9MZA9|https://www.uniprot.org/uniprot/Q96ML2|https://www.uniprot.org/uniprot/Q92155|https://www.uniprot.org/uniprot/Q91023|https://www.uniprot.org/uniprot/Q8N850|https://www.uniprot.org/uniprot/Q8CCH1|https://www.uniprot.org/uniprot/Q6LER9|https://www.uniprot.org/uniprot/Q5R1W8|https://www.uniprot.org/uniprot/Q548L2|https://www.uniprot.org/uniprot/Q4R4X4|https://www.uniprot.org/uniprot/Q3HWE4|https://www.uniprot.org/uniprot/Q17QM7|https://www.uniprot.org/uniprot/Q15869|https://www.uniprot.org/uniprot/Q15868|https://www.uniprot.org/uniprot/Q15867|https://www.uniprot.org/uniprot/P84198|https://www.uniprot.org/uniprot/P48674|https://www.uniprot.org/uniprot/P48670|https://www.uniprot.org/uniprot/P48616|https://www.uniprot.org/uniprot/P31000|https://www.uniprot.org/uniprot/P20152|https://www.uniprot.org/uniprot/P09654|https://www.uniprot.org/uniprot/P08670|https://www.uniprot.org/uniprot/P02544|https://www.uniprot.org/uniprot/P02543|https://www.uniprot.org/uniprot/O08704|https://www.uniprot.org/uniprot/F1RWC0|https://www.uniprot.org/uniprot/F1RWB8|https://www.uniprot.org/uniprot/D3DRU4|https://www.uniprot.org/uniprot/B0YJC2|https://www.uniprot.org/uniprot/A5A6N8
T6551 72311-72315 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6552 72481-72485 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6553 72568-72572 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6554 72626-72630 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6555 72893-72897 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6556 72971-72975 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6557 73127-73131 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6558 73212-73216 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6559 73298-73302 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6560 73357-73361 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6561 73530-73534 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6562 73664-73668 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6563 73849-73853 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6564 73987-73991 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6565 74104-74108 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6566 74131-74134 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6591 74174-74177 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6616 74327-74331 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6617 74491-74494 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6642 74585-74589 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6643 74797-74801 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6644 75052-75056 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6645 75066-75084 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T6749 75205-75209 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6750 75238-75242 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6751 75402-75406 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6752 75564-75568 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T12 392-399 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T13 1066-1071 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T14 1203-1208 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 1362-1366 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T16 1441-1455 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T17 1585-1591 http://purl.obolibrary.org/obo/BFO_0000030 denotes object
T18 2742-2750 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T19 3417-3422 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T20 4323-4328 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T21 5075-5083 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T22 5198-5206 http://purl.obolibrary.org/obo/BFO_0000034 denotes Function
T23 5571-5585 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T24 5621-5628 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T25 5918-5926 http://purl.obolibrary.org/obo/IDO_0000607 denotes products
T26 6600-6607 http://purl.obolibrary.org/obo/IDO_0000531 denotes hosting
T27 6908-6912 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T28 8778-8786 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T29 9116-9121 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T30 9267-9281 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T31 9303-9311 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T32 9348-9357 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T33 12256-12263 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T34 12761-12766 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T35 12785-12789 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T36 13036-13044 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Diseases
T37 13203-13209 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T38 13893-13898 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T39 14153-14158 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T40 14546-14550 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T41 14787-14795 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T42 16295-16300 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T43 16466-16472 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T44 16624-16629 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T45 16752-16757 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T46 17086-17092 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T47 17182-17187 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T48 17188-17193 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T49 17552-17557 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T50 18225-18230 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T51 18586-18591 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T52 18919-18923 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T53 19066-19075 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T54 19252-19257 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T55 19932-19937 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T56 20254-20260 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T57 20803-20811 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T58 20852-20857 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T59 20892-20897 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T60 21222-21231 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T61 21803-21815 http://purl.obolibrary.org/obo/GO_0000003 denotes reproductive
T62 21887-21892 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T63 21930-21938 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T64 22108-22113 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T65 22322-22327 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T66 22495-22499 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T67 22546-22550 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T68 22590-22595 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T69 22716-22721 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T70 22779-22784 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T71 22879-22884 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T72 22896-22902 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T73 23024-23028 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T74 24037-24042 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T75 24961-24967 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T76 25308-25318 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T77 25393-25397 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T78 25398-25404 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T79 25643-25648 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T80 26530-26537 http://purl.obolibrary.org/obo/IDO_0000607 denotes product
T81 26791-26796 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T82 26919-26925 http://purl.obolibrary.org/obo/IDO_0000636 denotes sepsis
T83 28195-28200 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T84 28252-28257 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T85 28348-28355 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T86 28669-28677 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T87 28689-28695 http://purl.obolibrary.org/obo/IDO_0000636 denotes sepsis
T88 28740-28745 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T89 28746-28756 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T90 28896-28905 http://purl.obolibrary.org/obo/IDO_0000552 denotes endotoxin
T91 28935-28941 http://purl.obolibrary.org/obo/IDO_0000636 denotes sepsis
T92 29061-29066 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T93 29110-29118 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T94 29518-29523 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T95 29892-29898 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T96 30086-30094 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T97 30512-30526 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T98 30647-30655 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T99 30677-30684 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T100 30899-30908 http://purl.obolibrary.org/obo/IDO_0000464 denotes infective
T101 30909-30916 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T102 31090-31098 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T103 31139-31144 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T104 31228-31233 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T105 31412-31416 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T106 31417-31422 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T107 31501-31505 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T108 31554-31562 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T109 31585-31589 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T110 31660-31665 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T111 31797-31807 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T112 31893-31901 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T113 31943-31951 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T114 32156-32163 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T115 32201-32208 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T116 32234-32246 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T117 32523-32527 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T118 32528-32537 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T119 33109-33114 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 33524-33528 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T121 33672-33677 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T122 33749-33753 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T123 33810-33817 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T124 33910-33920 http://purl.obolibrary.org/obo/BFO_0000034 denotes Functional
T125 34152-34156 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T126 34318-34328 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T127 34985-34989 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T128 34990-34994 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T129 35464-35471 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T130 35488-35492 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T131 35493-35497 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T132 35554-35559 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T133 35572-35578 http://purl.obolibrary.org/obo/IDO_0000586 denotes infect
T134 35579-35583 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T135 35772-35776 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T136 35791-35802 http://purl.obolibrary.org/obo/IDO_0000464 denotes infected by
T137 35791-35799 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T138 36039-36044 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T139 36154-36158 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T140 36187-36194 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T141 36403-36407 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T142 36771-36776 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T143 37208-37212 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T144 37505-37509 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T145 37520-37524 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T146 38003-38007 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T147 38008-38012 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T148 38325-38329 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T149 38330-38334 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T150 38515-38520 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T151 38529-38533 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T152 38534-38538 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T153 38903-38908 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 38932-38936 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T155 38957-38962 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T156 38977-38981 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T157 38982-38986 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T158 39110-39114 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T159 39511-39515 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T160 40001-40005 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T161 40006-40010 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T162 40080-40085 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T163 40323-40327 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T164 40632-40636 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T165 40927-40931 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T166 40932-40936 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T167 40981-40986 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T168 41170-41174 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T169 41221-41229 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T170 41483-41487 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T171 41518-41523 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T172 41534-41539 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T173 41548-41555 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T174 41638-41645 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T175 41680-41684 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T176 41697-41704 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T177 41756-41760 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T178 41835-41839 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T179 41923-41930 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T180 41981-41986 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T181 41999-42003 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T182 42137-42142 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T183 42247-42254 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T184 42328-42332 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T185 42418-42422 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T186 42423-42427 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T187 42960-42964 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T188 42980-42985 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T189 43169-43174 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T190 45255-45260 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T191 45761-45765 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T192 46078-46082 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T193 46200-46204 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T194 46205-46210 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T195 46281-46287 http://www.geneontology.org/formats/oboInOwl#Subset denotes subset
T196 46925-46929 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T197 49934-49938 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T198 49986-49990 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T199 50021-50025 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T200 50055-50060 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T201 50073-50086 http://purl.obolibrary.org/obo/IDO_0000450 denotes pathogenicity
T202 50226-50230 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T203 50321-50330 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T204 50524-50528 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T205 50795-50800 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T206 51061-51067 http://purl.obolibrary.org/obo/IDO_0000586 denotes infect
T207 51598-51606 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T208 51644-51652 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T209 51948-51956 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T210 52097-52105 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T211 52168-52175 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T212 52292-52299 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T213 52410-52417 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T214 52560-52567 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T215 52858-52865 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T216 53190-53195 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T217 54028-54037 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T218 55205-55214 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T219 55349-55358 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T220 55363-55370 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T221 55608-55615 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T222 55916-55920 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T223 55957-55966 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T224 56111-56116 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T225 56127-56136 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T226 56433-56441 http://purl.obolibrary.org/obo/TRANS_0000002 denotes indirect
T227 56467-56476 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T228 57369-57378 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T229 57388-57393 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T230 57481-57485 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T231 57826-57836 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T232 58202-58209 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T233 58575-58584 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T234 58884-58888 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T235 58896-58905 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T236 59185-59195 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T237 59554-59561 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T238 59726-59731 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T239 59786-59797 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T240 59801-59812 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptible
T241 59813-59818 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T242 59848-59853 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T243 59864-59869 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T244 59888-59893 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T245 60079-60083 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T246 60105-60116 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T247 60207-60211 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T248 60343-60351 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T249 60363-60367 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T250 60368-60372 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T251 60406-60414 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T252 60430-60438 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T253 60532-60536 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T254 60857-60861 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T255 61119-61128 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T256 61247-61257 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T257 61380-61390 http://purl.obolibrary.org/obo/TRANS_0000002 denotes indirectly
T258 61833-61838 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T259 62225-62235 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T260 62249-62255 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T261 62287-62297 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T262 62463-62473 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T263 63555-63560 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T264 63667-63677 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T265 63914-63919 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T266 64132-64141 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T267 64253-64258 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T268 64270-64274 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T269 64615-64624 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T270 64868-64882 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T271 65441-65451 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T272 65520-65530 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T273 66034-66043 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T274 66133-66137 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T275 66138-66142 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T276 66170-66181 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T277 66369-66378 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T278 66572-66576 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T279 67205-67209 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T280 67381-67385 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T281 67386-67390 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T282 67460-67464 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T283 67683-67688 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T284 67718-67728 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T285 68095-68104 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T286 68158-68163 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T287 68182-68199 http://purl.obolibrary.org/obo/GO_0044409 denotes entry in the host
T288 68195-68199 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T289 68200-68204 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T290 68687-68691 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T291 69207-69220 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections in
T292 69238-69243 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T293 69457-69461 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T294 69838-69843 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T295 69864-69883 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T296 69879-69883 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T297 69922-69927 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T298 70024-70033 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T299 70160-70168 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Diseases
T300 70471-70478 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T301 70974-70979 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T302 71080-71087 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T303 71302-71306 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T304 71307-71313 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T305 71760-71766 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T306 71821-71825 http://purl.obolibrary.org/obo/CL_0000000 denotes Cell
T307 72202-72210 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T308 72538-72543 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T309 72728-72732 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T310 72943-72947 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T311 73041-73045 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T312 74163-74170 http://purl.obolibrary.org/obo/IDO_0000607 denotes product
T313 74247-74257 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T314 74412-74417 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T315 74572-74581 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T316 74901-74908 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T317 75221-75225 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T318 75337-75351 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T14 113-121 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T15 451-456 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T16 1089-1101 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T17 1362-1366 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 1629-1633 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T19 2361-2365 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T20 2433-2440 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 3068-3079 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T22 3417-3422 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T23 4435-4440 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T24 4581-4586 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T25 4825-4832 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 4899-4904 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T27 4916-4922 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T28 5173-5179 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T29 5242-5246 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T30 5271-5281 Body_part denotes chromosome http://purl.org/sig/ont/fma/fma67093
T31 5309-5313 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T32 5333-5343 Body_part denotes chromosome http://purl.org/sig/ont/fma/fma67093
T33 5415-5419 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T34 5705-5709 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T35 5762-5773 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T36 5986-5996 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T37 6591-6598 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 7289-7299 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T39 7616-7623 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 7646-7657 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T41 8212-8216 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T42 8224-8236 Body_part denotes X chromosome http://purl.org/sig/ont/fma/fma84055
T43 8341-8353 Body_part denotes X chromosome http://purl.org/sig/ont/fma/fma84055
T44 8458-8469 Body_part denotes chromosomes http://purl.org/sig/ont/fma/fma67093
T45 8534-8541 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T46 8585-8589 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T47 8608-8614 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T48 8962-8968 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T49 9072-9078 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T50 9105-9121 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T51 9116-9121 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T52 9225-9229 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T53 9525-9531 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T54 9584-9591 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T55 9897-9905 Body_part denotes Estrogen http://purl.org/sig/ont/fma/fma83376
T56 10011-10019 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T57 10163-10169 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T58 10235-10243 Body_part denotes Estrogen http://purl.org/sig/ont/fma/fma83376
T59 10309-10317 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T60 10516-10525 Body_part denotes estrogens http://purl.org/sig/ont/fma/fma83376
T61 10627-10634 Body_part denotes histone http://purl.org/sig/ont/fma/fma74413
T62 10810-10817 Body_part denotes histone http://purl.org/sig/ont/fma/fma74413
T63 11062-11066 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T64 11114-11122 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T65 11256-11260 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T66 11337-11340 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T67 11399-11402 Body_part denotes H2A http://purl.org/sig/ont/fma/fma84129
T68 11403-11411 Body_part denotes histones http://purl.org/sig/ont/fma/fma74413
T69 11459-11463 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T70 11516-11525 Body_part denotes chromatin http://purl.org/sig/ont/fma/fma67526
T71 11604-11611 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 11845-11854 Body_part denotes Chromatin http://purl.org/sig/ont/fma/fma67526
T73 12251-12255 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T74 12299-12303 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T75 12326-12333 Body_part denotes Histone http://purl.org/sig/ont/fma/fma74413
T76 12670-12673 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T77 12745-12749 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T78 12750-12766 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T79 12761-12766 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T80 12785-12789 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T81 12830-12834 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T82 12835-12841 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T83 13185-13189 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T84 13318-13322 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T85 13771-13779 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T86 13881-13898 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T87 13893-13898 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T88 13915-13924 Body_part denotes chromatin http://purl.org/sig/ont/fma/fma67526
T89 14070-14075 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T90 14110-14114 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T91 14378-14382 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T92 14546-14559 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T93 14546-14550 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T94 14940-14950 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T95 15003-15013 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T96 15264-15270 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T97 15777-15783 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T98 15835-15842 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T99 15882-15889 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T100 15983-16004 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T101 16009-16015 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T102 16153-16160 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T103 16218-16229 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T104 16251-16259 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T105 16264-16269 Body_part denotes veins http://purl.org/sig/ont/fma/fma63814
T106 16281-16300 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T107 16295-16300 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T108 16325-16336 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T109 16534-16545 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T110 16593-16597 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T111 16612-16629 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T112 16624-16629 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T113 16672-16678 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T114 16692-16700 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T115 16738-16757 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T116 16752-16757 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 16765-16770 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T118 16826-16835 Body_part denotes mesangium http://purl.org/sig/ont/fma/fma84139
T119 16851-16862 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T120 16870-16876 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T121 16912-16921 Body_part denotes sinusoids http://purl.org/sig/ont/fma/fma63131
T122 16929-16934 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T123 17042-17058 Body_part denotes lymphatic system http://purl.org/sig/ont/fma/fma7162
T124 17100-17106 Body_part denotes spleen http://purl.org/sig/ont/fma/fma7196
T125 17108-17119 Body_part denotes lymph nodes http://purl.org/sig/ont/fma/fma5034
T126 17108-17113 Body_part denotes lymph http://purl.org/sig/ont/fma/fma9671
T127 17125-17136 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608
T128 17182-17187 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T129 17188-17193 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T130 17219-17228 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T131 17233-17244 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T132 17263-17276 Body_part denotes T lymphocytes http://purl.org/sig/ont/fma/fma62870
T133 17382-17387 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T134 17518-17532 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T135 17552-17557 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T136 17565-17580 Body_part denotes sinoatrial node http://purl.org/sig/ont/fma/fma9477
T137 17680-17685 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T138 17749-17762 Body_part denotes aortic valves http://purl.org/sig/ont/fma/fma7236
T139 17813-17827 Body_part denotes myofibroblasts http://purl.org/sig/ont/fma/fma0326458
T140 17832-17843 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T141 17884-17891 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T142 17953-17959 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T143 18188-18200 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T144 18225-18230 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 18298-18310 Body_part denotes Henle’s loop http://purl.org/sig/ont/fma/fma17698
T146 18343-18347 Body_part denotes duct http://purl.org/sig/ont/fma/fma30320
T147 18498-18515 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T148 18612-18623 Body_part denotes oral mucosa http://purl.org/sig/ont/fma/fma59660
T149 18617-18623 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T150 18632-18638 Body_part denotes larynx http://purl.org/sig/ont/fma/fma55097
T151 18640-18647 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T152 18661-18665 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T153 18736-18746 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T154 18895-18899 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T155 18919-18923 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T156 18924-18927 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T157 19036-19043 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T158 19150-19173 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T159 19221-19235 Body_part denotes lamina propria http://purl.org/sig/ont/fma/fma62517
T160 19245-19257 Body_part denotes muscle cells http://purl.org/sig/ont/fma/fma67328
T161 19252-19257 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T162 19269-19288 Body_part denotes salivary gland duct http://purl.org/sig/ont/fma/fma59908
T163 19289-19299 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T164 19308-19312 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T165 19341-19348 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T166 19397-19408 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T167 19830-19835 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T168 19881-19892 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T169 19911-19920 Body_part denotes bile duct http://purl.org/sig/ont/fma/fma9706
T170 19921-19937 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T171 19932-19937 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T172 19982-19993 Body_part denotes hepatocytes http://purl.org/sig/ont/fma/fma14515
T173 20063-20070 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 20102-20114 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T175 20118-20129 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T176 20150-20165 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T177 20181-20189 Body_part denotes duodenum http://purl.org/sig/ont/fma/fma7206
T178 20191-20198 Body_part denotes jejunum http://purl.org/sig/ont/fma/fma7207
T179 20204-20209 Body_part denotes ileum http://purl.org/sig/ont/fma/fma7208
T180 20222-20233 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T181 20241-20246 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T182 20268-20283 Body_part denotes digestive tract http://purl.org/sig/ont/fma/fma317863
T183 20297-20304 Body_part denotes stomach http://purl.org/sig/ont/fma/fma7148
T184 20309-20314 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T185 20329-20341 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T186 20399-20406 Body_part denotes mucosae http://purl.org/sig/ont/fma/fma85355
T187 20535-20541 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T188 20563-20583 Body_part denotes islets of Langerhans http://purl.org/sig/ont/fma/fma76489
T189 20670-20675 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T190 20686-20699 Body_part denotes telencephalon http://purl.org/sig/ont/fma/fma62000
T191 20707-20714 Body_part denotes medulla http://purl.org/sig/ont/fma/fma61108
T192 20746-20751 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T193 20843-20878 Body_part denotes vascular organ of lamina terminalis http://purl.org/sig/ont/fma/fma62315
T194 20880-20897 Body_part denotes subfornical organ http://purl.org/sig/ont/fma/fma75260
T195 20913-20920 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T196 20941-20964 Body_part denotes paraventricular nucleus http://purl.org/sig/ont/fma/fma62320
T197 20966-20979 Body_part denotes area postrema http://purl.org/sig/ont/fma/fma72607
T198 20981-21010 Body_part denotes nucleus of the solitary tract http://purl.org/sig/ont/fma/fma256691
T199 20996-21010 Body_part denotes solitary tract http://purl.org/sig/ont/fma/fma72619
T200 21040-21045 Body_part denotes vagus http://purl.org/sig/ont/fma/fma5731
T201 21092-21099 Body_part denotes medulla http://purl.org/sig/ont/fma/fma61108
T202 21181-21186 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T203 21265-21271 Body_part denotes cortex http://purl.org/sig/ont/fma/fma61109
T204 21273-21284 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T205 21294-21301 Body_part denotes putamen http://purl.org/sig/ont/fma/fma61834
T206 21303-21322 Body_part denotes hypoglossal nucleus http://purl.org/sig/ont/fma/fma54505
T207 21327-21347 Body_part denotes primary motor cortex http://purl.org/sig/ont/fma/fma224854
T208 21445-21452 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T209 21464-21474 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T210 21590-21596 Body_part denotes retina http://purl.org/sig/ont/fma/fma58301
T211 21651-21665 Body_part denotes photoreceptors http://purl.org/sig/ont/fma/fma85613
T212 21735-21751 Body_part denotes endocrine system http://purl.org/sig/ont/fma/fma9668
T213 21803-21823 Body_part denotes reproductive systems http://purl.org/sig/ont/fma/fma7160
T214 21834-21840 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T215 21879-21892 Body_part denotes Sertoli cells http://purl.org/sig/ont/fma/fma72298
T216 21887-21892 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T217 21994-22001 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T218 22079-22085 Body_part denotes stroma http://purl.org/sig/ont/fma/fma81494
T219 22098-22113 Body_part denotes granulosa cells http://purl.org/sig/ont/fma/fma18718
T220 22108-22113 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T221 22268-22279 Body_part denotes osteoblasts http://purl.org/sig/ont/fma/fma66780
T222 22284-22295 Body_part denotes osteoclasts http://purl.org/sig/ont/fma/fma66781
T223 22311-22327 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T224 22322-22327 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T225 22332-22343 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T226 22459-22463 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T227 22489-22522 Body_part denotes basal cell layer of the epidermis http://purl.org/sig/ont/fma/fma67540
T228 22489-22499 Body_part denotes basal cell http://purl.org/sig/ont/fma/fma62516
T229 22495-22499 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T230 22513-22522 Body_part denotes epidermis http://purl.org/sig/ont/fma/fma70596
T231 22540-22550 Body_part denotes basal cell http://purl.org/sig/ont/fma/fma62516
T232 22546-22550 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T233 22560-22574 Body_part denotes hair follicles http://purl.org/sig/ont/fma/fma70660
T234 22576-22595 Body_part denotes Smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T235 22590-22595 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T236 22612-22628 Body_part denotes sebaceous glands http://purl.org/sig/ont/fma/fma71874
T237 22663-22674 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T238 22700-22715 Body_part denotes sebaceous gland http://purl.org/sig/ont/fma/fma59160
T239 22716-22721 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T240 22779-22784 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T241 22792-22806 Body_part denotes eccrine glands http://purl.org/sig/ont/fma/fma59154
T242 22800-22806 Body_part denotes glands http://purl.org/sig/ont/fma/fma71481
T243 22875-22884 Body_part denotes fat cells http://purl.org/sig/ont/fma/fma63880
T244 22879-22884 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T245 22929-22943 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T246 23024-23038 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T247 23024-23028 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T248 23187-23192 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T249 23197-23203 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T250 23254-23261 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T251 23271-23277 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T252 23820-23841 Body_part denotes left ventricular wall http://purl.org/sig/ont/fma/fma9556
T253 24037-24042 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T254 24979-24984 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T255 24995-25000 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T256 25053-25057 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T257 25094-25098 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T258 25126-25134 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T259 25243-25257 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T260 25299-25307 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T261 25335-25349 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T262 25393-25397 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T263 25620-25648 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T264 25643-25648 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T265 25870-25884 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T266 26707-26716 Body_part denotes G-protein http://purl.org/sig/ont/fma/fma61788
T267 26772-26786 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T268 26791-26804 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T269 26791-26796 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T270 27227-27238 Body_part denotes neurotensin http://purl.org/sig/ont/fma/fma83371
T271 27433-27438 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T272 28121-28125 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T273 28175-28200 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T274 28195-28200 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T275 28240-28257 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T276 28252-28257 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T277 28297-28300 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T278 28343-28347 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T279 28438-28442 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T280 28649-28653 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T281 29015-29019 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T282 29061-29066 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T283 29331-29335 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T284 29444-29454 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T285 29511-29523 Body_part denotes goblet cells http://purl.org/sig/ont/fma/fma13148
T286 29518-29523 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T287 29829-29837 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T288 30008-30012 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T289 30056-30060 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T290 30104-30109 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T291 30148-30152 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T292 30185-30193 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T293 30396-30400 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T294 31135-31138 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T295 31234-31240 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T296 31304-31316 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T297 31417-31422 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T298 31501-31505 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T299 31578-31584 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T300 31585-31589 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T301 31631-31643 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T302 32523-32527 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T303 32690-32697 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T304 32737-32745 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T305 32814-32822 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T306 32830-32838 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T307 32857-32862 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T308 32912-32918 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T309 33159-33171 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T310 33344-33351 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T311 33524-33528 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T312 33571-33578 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T313 33749-33753 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T314 33961-33968 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T315 34003-34010 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T316 34029-34039 Body_part denotes aminoacids http://purl.org/sig/ont/fma/fma82739
T317 34238-34256 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T318 34647-34668 Body_part denotes contacts the receptor http://purl.org/sig/ont/fma/fma85595
T319 34839-34850 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T320 34936-34943 Body_part denotes glycine http://purl.org/sig/ont/fma/fma82753
T321 34951-34958 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T322 34990-35003 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T323 34990-34994 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T324 35368-35376 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T325 35493-35497 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T326 35579-35583 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T327 35772-35776 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T328 36039-36044 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T329 36154-36158 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T330 36403-36407 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T331 36577-36584 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T332 37845-37850 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T333 38008-38021 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T334 38008-38012 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T335 38106-38111 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T336 38330-38344 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T337 38330-38334 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T338 38534-38538 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T339 38539-38548 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T340 38584-38590 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T341 38689-38696 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T342 38932-38936 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T343 38982-38986 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T344 39343-39350 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T345 39511-39524 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T346 39511-39515 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T347 39538-39553 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T348 39573-39582 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T349 39603-39620 Body_part denotes endocytic vesicle http://purl.org/sig/ont/fma/fma67463
T350 39677-39684 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T351 39804-39811 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T352 40006-40010 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T353 40154-40160 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T354 40238-40247 Body_part denotes aminoacid http://purl.org/sig/ont/fma/fma82739
T355 40460-40472 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T356 40632-40636 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T357 40932-40945 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T358 40932-40936 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T359 40970-40986 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T360 40981-40986 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T361 40996-41005 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T362 41170-41174 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T363 41370-41385 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T364 41392-41401 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T365 41518-41523 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T366 41534-41539 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T367 41680-41684 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T368 41756-41760 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T369 41907-41910 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T370 41949-41955 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T371 41999-42003 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T372 42096-42111 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T373 42203-42221 Body_part denotes endocytic vesicles http://purl.org/sig/ont/fma/fma67463
T374 42328-42332 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T375 42423-42427 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T376 42571-42578 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T377 42960-42972 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T378 42960-42964 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T379 42980-42985 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T380 43140-43148 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T381 43169-43174 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T382 44594-44601 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T383 45255-45260 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T384 45446-45453 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T385 45740-45753 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T386 46022-46029 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T387 46205-46210 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T388 46267-46274 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T389 47626-47633 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T390 47857-47864 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T391 48242-48247 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T392 48380-48385 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T393 48819-48824 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T394 50290-50297 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T395 50524-50528 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T396 51271-51276 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T397 52978-52984 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T398 53190-53195 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T399 55229-55233 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T400 55916-55929 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T401 55916-55920 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T402 57388-57393 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T403 57481-57485 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T404 57561-57569 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T405 57995-57999 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T406 58322-58327 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T407 58360-58371 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T408 59199-59203 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T409 59392-59401 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T410 59478-59486 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T411 59628-59636 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T412 59813-59818 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T413 59828-59853 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T414 59848-59853 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T415 59864-59869 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T416 59874-59887 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T417 59888-59893 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T418 59895-59906 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T419 59908-59917 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T420 60079-60083 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T421 60207-60211 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T422 60368-60372 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T423 60584-60591 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T424 60631-60638 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T425 60658-60665 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T426 60706-60713 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T427 60834-60843 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T428 60857-60861 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T429 61070-61078 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T430 61179-61190 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T431 61277-61286 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T432 61296-61300 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T433 61416-61421 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T434 61431-61435 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T435 61604-61614 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T436 62399-62408 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T437 62739-62747 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T438 62850-62854 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T439 63095-63102 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T440 63548-63554 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T441 63555-63560 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T442 63914-63919 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T443 64152-64165 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T444 64242-64258 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T445 64253-64258 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T446 64270-64274 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T447 64337-64341 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T448 65637-65645 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T449 66138-66142 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T450 66201-66205 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T451 66543-66550 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T452 67381-67385 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T453 67386-67390 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T454 67488-67495 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T455 67703-67707 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T456 68200-68204 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T457 68324-68328 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T458 68664-68671 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T459 68878-68885 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T460 69238-69250 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T461 69271-69277 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T462 69457-69461 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T463 69745-69749 Body_part denotes nose http://purl.org/sig/ont/fma/fma46472
T464 70112-70116 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T465 70189-70196 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T466 70321-70327 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T467 70328-70335 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T468 70348-70359 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T469 70376-70383 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T470 70503-70514 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T471 70571-70581 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T472 70595-70600 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T473 70605-70608 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T474 70723-70730 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T475 70751-70759 Body_part denotes pancreas http://purl.org/sig/ont/fma/fma7198
T476 70813-70820 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T477 70923-70937 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T478 70974-70979 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T479 71302-71306 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T480 71347-71353 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T481 71432-71437 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T482 71821-71825 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T483 71826-71830 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T484 71942-71952 Body_part denotes E-cadherin http://purl.org/sig/ont/fma/fma61792
T485 71996-72004 Body_part denotes vimentin http://purl.org/sig/ont/fma/fma67330
T486 72140-72144 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T487 72486-72490 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T488 72676-72681 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T489 72705-72711 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T490 72728-72732 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T491 72785-72791 Body_part denotes rectum http://purl.org/sig/ont/fma/fma14544
T492 72815-72822 Body_part denotes stomach http://purl.org/sig/ont/fma/fma7148
T493 72850-72854 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T494 72929-72933 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T495 72943-72947 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T496 73041-73045 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T497 73054-73061 Body_part denotes thyroid http://purl.org/sig/ont/fma/fma9603
T498 73084-73090 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T499 73937-73951 Body_part denotes uterine corpus http://purl.org/sig/ont/fma/fma17739
T500 74339-74344 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T501 74346-74352 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T502 74412-74417 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T503 74643-74651 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T504 74741-74758 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T505 75072-75084 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T506 75168-75175 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T507 75221-75233 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T508 75221-75225 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T24 377-399 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T25 423-435 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T26 440-464 Disease denotes congestive heart failure http://purl.obolibrary.org/obo/MONDO_0005009
T27 1057-1065 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 1057-1061 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T29 1192-1202 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T30 1192-1196 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T31 1244-1252 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T32 1374-1386 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T33 1432-1440 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T34 1506-1518 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T35 1711-1721 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T36 1711-1715 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T37 2727-2750 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T38 3911-3914 Disease denotes EST http://purl.obolibrary.org/obo/MONDO_0023726
T39 4047-4055 Disease denotes lymphoma http://purl.obolibrary.org/obo/MONDO_0005062
T40 4435-4448 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T41 4638-4671 Disease denotes idiopathic dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0016333
T42 5589-5628 Disease denotes hypertension and cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T43 9294-9302 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T44 9337-9347 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T45 9337-9341 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T46 9348-9357 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T47 9390-9398 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 11713-11717 Disease denotes ESCs http://purl.obolibrary.org/obo/MONDO_0009989
T49 12012-12016 Disease denotes ESCs http://purl.obolibrary.org/obo/MONDO_0009989
T50 12203-12215 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T51 12217-12225 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T52 12231-12263 Disease denotes chronic obstructive lung disease http://purl.obolibrary.org/obo/MONDO_0005002
T53 12978-12984 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T54 13592-13600 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T55 13648-13658 Disease denotes Sars-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T56 15477-15487 Disease denotes Sars-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T57 19047-19057 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T58 19047-19051 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 19066-19075 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 19131-19139 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 24032-24051 Disease denotes high blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T62 25902-25923 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T63 25925-25927 Disease denotes MI http://purl.obolibrary.org/obo/MONDO_0005068
T64 26196-26218 Disease denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0005021
T65 27433-27446 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T66 27698-27710 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T67 28126-28132 Disease denotes Injury http://purl.obolibrary.org/obo/MONDO_0021178
T68 28343-28355 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T69 28432-28449 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T71 28451-28454 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T72 28457-28475 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T73 28477-28499 Disease denotes pulmonary hypertension http://purl.obolibrary.org/obo/MONDO_0005149
T74 28505-28540 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T75 28542-28546 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T76 28575-28579 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T77 28612-28615 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T78 28654-28660 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T79 28714-28726 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T80 28728-28735 Disease denotes anthrax http://purl.obolibrary.org/obo/MONDO_0005119
T81 28740-28756 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T82 28766-28769 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T83 28776-28785 Disease denotes avian flu http://purl.obolibrary.org/obo/MONDO_0018695
T84 28790-28794 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T85 28863-28867 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T86 28960-28964 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T87 29048-29060 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T88 29336-29348 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T89 29420-29435 Disease denotes allergic asthma http://purl.obolibrary.org/obo/MONDO_0004784
T90 29484-29496 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T91 29680-29686 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T92 30013-30025 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T93 30507-30511 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T94 30661-30676 Disease denotes avian influenza http://purl.obolibrary.org/obo/MONDO_0018695
T95 30816-30824 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 30887-30908 Disease denotes respiratory infective http://purl.obolibrary.org/obo/MONDO_0024355
T97 30927-30960 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T98 30962-30966 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 31191-31199 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 31191-31195 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 31533-31541 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 31533-31537 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 31733-31741 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 31733-31737 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 31753-31757 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 31797-31807 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T107 32002-32011 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T108 32079-32089 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T109 32079-32083 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T110 32123-32131 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 32123-32127 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T112 32179-32187 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 32189-32213 Disease denotes COronaVIrus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T114 32264-32274 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T115 32264-32268 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T116 32421-32429 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 32476-32486 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T118 32476-32480 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T119 32528-32537 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T120 33331-33341 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T121 33331-33335 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T122 33421-33429 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 33421-33425 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T124 33494-33504 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T125 33494-33498 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T126 33548-33556 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T127 33548-33552 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T128 33686-33694 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T129 33686-33690 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T130 33700-33710 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T131 33700-33704 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T132 33787-33795 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 33787-33791 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T134 33799-33809 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T135 33799-33803 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T136 33972-33980 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T137 33972-33976 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T138 33985-33995 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T139 33985-33989 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T140 34510-34518 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T141 34510-34514 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T142 34534-34544 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T143 34534-34538 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T144 35380-35388 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 35380-35384 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T146 35393-35403 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T147 35393-35397 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T148 35815-35825 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T149 35815-35819 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T150 35829-35837 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 35829-35833 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T152 36126-36136 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T153 36126-36130 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T154 36343-36351 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 36343-36347 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 36356-36366 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T157 36356-36360 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 36427-36435 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 36427-36431 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T160 36440-36450 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T161 36440-36444 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T162 39688-39698 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T163 39688-39692 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T164 40069-40079 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T165 40069-40073 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T166 40143-40153 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T167 40143-40147 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T168 40177-40185 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T169 40177-40181 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T170 40529-40539 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T171 40529-40533 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T172 40673-40681 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T173 40673-40677 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T174 40707-40717 Disease denotes SARS-COV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T175 40707-40711 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T176 41159-41169 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T177 41159-41163 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T178 41212-41220 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T179 42335-42345 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T180 42335-42339 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 42379-42389 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T182 42379-42383 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T183 42394-42402 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 42394-42398 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 42470-42480 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T186 42470-42474 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T187 42511-42519 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T188 42511-42515 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T189 42521-42529 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T190 42521-42525 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T191 42647-42657 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T192 42647-42651 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T193 42704-42712 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T194 42704-42708 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T195 42820-42830 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T196 42820-42824 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T197 42876-42886 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T198 42876-42880 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 43207-43217 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T200 43207-43211 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T201 43314-43324 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T202 43314-43318 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T203 43744-43754 Disease denotes SARS-COV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T204 43744-43748 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T205 43759-43767 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T206 43759-43763 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T207 43977-43987 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T208 43977-43981 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T209 44131-44141 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T210 44131-44135 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T211 44397-44407 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T212 44397-44401 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T213 44494-44504 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T214 44494-44498 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T215 44965-44975 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T216 44965-44969 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T217 45034-45042 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T218 45034-45038 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T219 45214-45224 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T220 45214-45218 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 45262-45272 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T222 45262-45266 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T223 45296-45304 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T224 45296-45300 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T225 45433-45443 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T226 45433-45437 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 45493-45497 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T228 45560-45570 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T229 45560-45564 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T230 45629-45637 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T231 45629-45633 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T232 45807-45817 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T233 45807-45811 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T234 45822-45830 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T235 45822-45826 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T236 45866-45876 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T237 45866-45870 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 46179-46189 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T239 46179-46183 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T240 46246-46256 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T241 46246-46250 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T242 46344-46348 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T243 46384-46388 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T244 46422-46426 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T245 46472-46476 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T246 46525-46529 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T247 46575-46579 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T248 46623-46627 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T249 46690-46694 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T250 46933-46941 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T251 46933-46937 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T252 47057-47065 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T253 47057-47061 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T254 47236-47246 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T255 47236-47240 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T256 47312-47322 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T257 47312-47316 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T258 47986-47994 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T259 47986-47990 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T260 48008-48018 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T261 48008-48012 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 48083-48093 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T263 48083-48087 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T264 48128-48138 Disease denotes S sequence http://purl.obolibrary.org/obo/MONDO_0007821
T265 48153-48161 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T266 48153-48157 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T267 48754-48764 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T268 48754-48758 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T269 48769-48777 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T270 48769-48773 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T271 48806-48814 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T272 48806-48810 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T273 48893-48903 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T274 48893-48897 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T275 49085-49095 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T276 49085-49089 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T277 49123-49127 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T278 49462-49472 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T279 49462-49466 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T280 49489-49493 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T281 49598-49608 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T282 49598-49602 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T283 50277-50287 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T284 50277-50281 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T285 50312-50320 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T286 50321-50330 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T287 50610-50614 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T288 50627-50637 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T289 50627-50631 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T290 50715-50723 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T291 50715-50719 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T292 50866-50876 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T293 50866-50870 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T294 51301-51311 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T295 51301-51305 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T296 51490-51498 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T297 51615-51652 Disease denotes hypertension, cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0001302
T298 51657-51681 Disease denotes type-2 diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005148
T299 52039-52051 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T300 52061-52069 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T301 52082-52105 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T302 52255-52267 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T303 52277-52299 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T304 52467-52475 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T305 52689-52701 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T306 52803-52815 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T307 52823-52831 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T308 52843-52865 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T309 52898-52906 Disease denotes Diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T310 52954-52958 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T311 52972-52991 Disease denotes acute kidney injury http://purl.obolibrary.org/obo/MONDO_0002492
T312 53246-53253 Disease denotes Obesity http://purl.obolibrary.org/obo/MONDO_0011122
T313 53309-53317 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T314 53336-53343 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T315 53404-53414 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T316 53404-53408 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T317 53734-53737 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T318 54019-54037 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T319 54019-54023 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T320 54111-54121 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T321 54111-54115 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T322 54207-54217 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T323 54207-54211 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T324 54276-54279 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T325 54635-54639 Disease denotes Park http://purl.obolibrary.org/obo/MONDO_0008199
T326 54926-54929 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T327 55156-55168 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T328 55205-55214 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T329 55343-55358 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T330 55579-55615 Disease denotes hypertension, cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T331 55620-55628 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T332 55702-55712 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T333 55702-55706 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T334 55946-55956 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T335 55946-55950 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T336 55957-55966 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T337 56127-56136 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T338 56616-56624 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T339 56629-56641 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T340 56663-56666 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T341 56996-56999 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T342 57017-57025 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T343 57135-57143 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T344 57358-57368 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T345 57358-57362 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T346 57369-57378 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T347 57668-57676 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T348 57777-57787 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T349 57777-57781 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T350 57811-57814 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T351 57820-57836 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T352 57838-57845 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T353 57973-57977 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T354 58000-58006 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T355 58109-58113 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T356 58179-58187 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T357 58193-58209 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938
T358 58233-58242 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T359 58522-58528 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T360 58575-58584 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T361 58642-58650 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T362 58896-58905 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T363 59022-59030 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T364 59035-59044 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T365 59074-59078 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T366 60141-60153 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T367 60519-60523 Disease denotes PRRs http://purl.obolibrary.org/obo/MONDO_0025494
T368 60565-60568 Disease denotes NOD http://purl.obolibrary.org/obo/MONDO_0007435
T369 60667-60670 Disease denotes ASC http://purl.obolibrary.org/obo/MONDO_0019018
T370 60881-60893 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T371 61089-61099 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T372 61089-61093 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T373 61108-61118 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T374 61108-61112 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T375 61119-61128 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T376 61326-61334 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T377 61499-61510 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T378 61531-61539 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T379 61540-61549 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T380 61615-61621 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T381 61723-61733 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T382 61723-61727 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T383 63009-63021 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T384 64126-64141 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T385 64609-64624 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T386 64718-64728 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T387 64718-64722 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T388 64886-64896 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T389 64886-64890 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T390 65046-65063 Disease denotes hypovitaminosis D http://purl.obolibrary.org/obo/MONDO_0005520
T391 65089-65097 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T392 65274-65284 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T393 65274-65278 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T394 65317-65327 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T395 65317-65321 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T396 65409-65426 Disease denotes hypovitaminosis D http://purl.obolibrary.org/obo/MONDO_0005520
T397 65441-65451 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T398 65508-65530 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T399 65690-65700 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T400 65690-65694 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T401 65889-65897 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T402 65949-65959 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T403 65949-65953 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T404 66034-66043 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T405 66206-66212 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T406 66369-66378 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T407 67054-67062 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T408 67054-67058 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T409 67276-67284 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T410 67276-67280 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T411 67579-67583 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T412 67697-67714 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T414 67718-67728 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T415 67734-67738 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T416 68129-68139 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T417 68129-68133 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T418 68329-68335 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T419 68510-68518 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T420 68816-68824 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T421 69079-69083 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T422 69196-69206 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T423 69196-69200 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T424 69207-69220 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T425 69426-69436 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T426 69426-69430 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T427 69533-69543 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T428 69533-69537 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T429 70018-70033 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T430 70461-70478 Disease denotes Hartnup’s disease http://purl.obolibrary.org/obo/MONDO_0009324
T431 70751-70759 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040
T432 70852-70859 Disease denotes Obesity http://purl.obolibrary.org/obo/MONDO_0011122
T433 70964-70988 Disease denotes increased blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T434 71070-71087 Disease denotes Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0004975
T435 71142-71149 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T436 71261-71267 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T437 71295-71301 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T438 71432-71444 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T439 71501-71525 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T440 71754-71759 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T441 71811-71837 Disease denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/MONDO_0005233
T442 71839-71844 Disease denotes NSCLC http://purl.obolibrary.org/obo/MONDO_0005233
T443 72068-72073 Disease denotes NSCLC http://purl.obolibrary.org/obo/MONDO_0005233
T444 72140-72151 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T445 72173-72181 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T446 72403-72409 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T447 72411-72415 Disease denotes Chai http://purl.obolibrary.org/obo/MONDO_0014493
T448 72507-72513 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T449 72668-72674 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T450 72676-72696 Disease denotes colon adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002271
T451 72698-72702 Disease denotes COAD http://purl.obolibrary.org/obo/MONDO_0002271
T452 72733-72742 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993
T453 72751-72776 Disease denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0006047
T454 72778-72782 Disease denotes PAAD http://purl.obolibrary.org/obo/MONDO_0006047
T455 72785-72806 Disease denotes rectum adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002169
T456 72808-72812 Disease denotes READ http://purl.obolibrary.org/obo/MONDO_0002169
T457 72815-72837 Disease denotes stomach adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005036
T458 72839-72843 Disease denotes STAD http://purl.obolibrary.org/obo/MONDO_0005036
T459 72850-72869 Disease denotes lung adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005061
T460 72871-72875 Disease denotes LUAD http://purl.obolibrary.org/obo/MONDO_0005061
T461 72929-72957 Disease denotes lung squamous cell carcinoma http://purl.obolibrary.org/obo/MONDO_0005097
T462 72959-72963 Disease denotes LUSC http://purl.obolibrary.org/obo/MONDO_0005097
T463 73017-73023 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T464 73047-73051 Disease denotes TGCT http://purl.obolibrary.org/obo/MONDO_0006906|http://purl.obolibrary.org/obo/MONDO_0010108
T466 73054-73071 Disease denotes thyroid carcinoma http://purl.obolibrary.org/obo/MONDO_0015075
T467 73073-73077 Disease denotes THCA http://purl.obolibrary.org/obo/MONDO_0015075
T468 73084-73102 Disease denotes kidney chromophobe http://purl.obolibrary.org/obo/MONDO_0017885
T469 73104-73108 Disease denotes KICH http://purl.obolibrary.org/obo/MONDO_0017885
T470 73832-73837 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T471 73937-73973 Disease denotes uterine corpus endometrial carcinoma http://purl.obolibrary.org/obo/MONDO_0000553
T472 73975-73979 Disease denotes UCEC http://purl.obolibrary.org/obo/MONDO_0000553
T473 74771-74779 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T474 74878-74882 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T475 74891-74900 Disease denotes SARS-Cov2 http://purl.obolibrary.org/obo/MONDO_0100096
T476 74891-74895 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T477 75328-75336 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T478 75573-75581 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T5 414-422 http://purl.obolibrary.org/obo/MAT_0000034 denotes arterial
T6 451-456 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T7 1629-1633 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand
T8 3417-3422 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T9 3417-3422 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T10 4435-4440 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T11 4581-4596 http://purl.obolibrary.org/obo/MAT_0000497 denotes heart ventricle
T12 4581-4586 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T13 4899-4904 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T14 4916-4922 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T15 7223-7228 http://purl.obolibrary.org/obo/MAT_0000239 denotes stems
T16 8317-8321 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T17 9072-9078 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T18 9189-9193 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T19 9225-9229 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T20 9285-9290 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T21 12251-12255 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T22 12299-12303 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T23 12745-12749 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T24 12830-12834 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T25 13185-13189 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T26 14070-14075 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T27 15983-16004 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T28 16009-16015 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T29 16218-16229 http://purl.obolibrary.org/obo/MAT_0000393 denotes vasculature
T30 16251-16259 http://purl.obolibrary.org/obo/MAT_0000034 denotes arteries
T31 16264-16269 http://purl.obolibrary.org/obo/MAT_0000037 denotes veins
T32 16281-16294 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T33 16288-16294 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T34 16400-16407 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T35 16511-16518 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T36 16593-16597 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T37 16672-16678 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T38 16692-16700 http://purl.obolibrary.org/obo/MAT_0000034 denotes arteries
T39 16738-16751 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T40 16745-16751 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T41 16765-16770 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T42 16870-16876 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T43 16929-16934 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T44 17042-17058 http://purl.obolibrary.org/obo/MAT_0000197 denotes lymphatic system
T45 17100-17106 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T46 17108-17119 http://purl.obolibrary.org/obo/MAT_0000197 denotes lymph nodes
T47 17108-17119 http://purl.obolibrary.org/obo/MAT_0000442 denotes lymph nodes
T48 17108-17113 http://purl.obolibrary.org/obo/MAT_0000055 denotes lymph
T49 17125-17136 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow
T50 17125-17129 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T51 17182-17193 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood cells
T52 17182-17187 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T53 17382-17387 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T54 17453-17459 http://purl.obolibrary.org/obo/MAT_0000496 denotes atrium
T55 17463-17472 http://purl.obolibrary.org/obo/MAT_0000497 denotes ventricle
T56 17680-17685 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T57 17953-17959 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T58 18208-18216 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T59 18632-18638 http://purl.obolibrary.org/obo/MAT_0000187 denotes larynx
T60 18640-18647 http://purl.obolibrary.org/obo/MAT_0000137 denotes trachea
T61 18661-18665 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T62 19245-19251 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T63 19269-19283 http://purl.obolibrary.org/obo/MAT_0000079 denotes salivary gland
T64 19278-19283 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland
T65 19308-19312 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T66 19730-19735 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T67 19830-19835 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T68 19874-19880 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessel
T69 20150-20165 http://purl.obolibrary.org/obo/MAT_0000047 denotes small intestine
T70 20156-20165 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestine
T71 20181-20189 http://purl.obolibrary.org/obo/MAT_0000044 denotes duodenum
T72 20191-20198 http://purl.obolibrary.org/obo/MAT_0000045 denotes jejunum
T73 20204-20209 http://purl.obolibrary.org/obo/MAT_0000282 denotes ileum
T74 20241-20246 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T75 20297-20304 http://purl.obolibrary.org/obo/MAT_0000051 denotes stomach
T76 20309-20314 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T77 20563-20583 http://purl.obolibrary.org/obo/MAT_0000076 denotes islets of Langerhans
T78 20670-20675 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T79 20686-20699 http://purl.obolibrary.org/obo/MAT_0000421 denotes telencephalon
T80 20746-20751 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T81 21012-21018 http://purl.obolibrary.org/obo/MAT_0000487 denotes dorsal
T82 21181-21186 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T83 21273-21284 http://purl.obolibrary.org/obo/MAT_0000114 denotes hippocampus
T84 21590-21596 http://purl.obolibrary.org/obo/MAT_0000142 denotes retina
T85 21735-21751 http://purl.obolibrary.org/obo/MAT_0000021 denotes endocrine system
T86 21787-21791 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T87 21796-21823 http://purl.obolibrary.org/obo/MAT_0000028 denotes female reproductive systems
T88 21834-21840 http://purl.obolibrary.org/obo/MAT_0000132 denotes testis
T89 22241-22245 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T90 22459-22463 http://purl.obolibrary.org/obo/MAT_0000284 denotes skin
T91 22513-22522 http://purl.obolibrary.org/obo/MAT_0000154 denotes epidermis
T92 22560-22564 http://purl.obolibrary.org/obo/MAT_0000160 denotes hair
T93 22576-22589 http://purl.obolibrary.org/obo/MAT_0000303 denotes Smooth muscle
T94 22583-22589 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T95 22622-22628 http://purl.obolibrary.org/obo/MAT_0000021 denotes glands
T96 22710-22715 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland
T97 22800-22806 http://purl.obolibrary.org/obo/MAT_0000021 denotes glands
T98 22929-22943 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue
T99 23187-23192 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T100 23197-23203 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T101 24037-24042 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T102 24037-24042 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T103 24979-24984 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T104 24986-24993 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T105 24995-25000 http://purl.obolibrary.org/obo/MAT_0000135 denotes lungs
T106 25629-25642 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T107 25636-25642 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T108 25875-25884 http://purl.obolibrary.org/obo/MAT_0000497 denotes ventricle
T109 26152-26158 http://purl.obolibrary.org/obo/MAT_0000036 denotes hearts
T110 26791-26804 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessels
T111 26791-26796 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T112 26791-26796 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T113 27433-27438 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T114 28121-28125 http://purl.obolibrary.org/obo/MAT_0000135 denotes Lung
T115 28224-28231 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T116 28343-28347 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T117 28438-28442 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T118 28649-28653 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T119 28994-29000 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessel
T120 29015-29019 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T121 29331-29335 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T122 30008-30012 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T123 30104-30109 http://purl.obolibrary.org/obo/MAT_0000135 denotes lungs
T124 31578-31584 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T125 36709-36714 http://purl.obolibrary.org/obo/MAT_0000294 denotes heads
T126 46884-46888 http://purl.obolibrary.org/obo/MAT_0000158 denotes claw
T127 48991-48999 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T128 51548-51553 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T129 52978-52984 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T130 55229-55233 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand
T131 57995-57999 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T132 58322-58327 http://purl.obolibrary.org/obo/MAT_0000135 denotes lungs
T133 63548-63554 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T134 66201-66205 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T135 67703-67707 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T136 68324-68328 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T137 69238-69250 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessel
T138 69238-69243 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T139 69238-69243 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T140 69271-69277 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T141 69745-69749 http://purl.obolibrary.org/obo/MAT_0000139 denotes nose
T142 70321-70327 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T143 70605-70608 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut
T144 70751-70759 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas
T145 70923-70937 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue
T146 70974-70979 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T147 70974-70979 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T148 71432-71437 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T149 71826-71830 http://purl.obolibrary.org/obo/MAT_0000135 denotes Lung
T150 72140-72144 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T151 72676-72681 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T152 72705-72711 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T153 72785-72791 http://purl.obolibrary.org/obo/MAT_0000050 denotes rectum
T154 72815-72822 http://purl.obolibrary.org/obo/MAT_0000051 denotes stomach
T155 72850-72854 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T156 72929-72933 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T157 73036-73045 http://purl.obolibrary.org/obo/MAT_0000334 denotes germ cell
T158 73054-73061 http://purl.obolibrary.org/obo/MAT_0000081 denotes thyroid
T159 73084-73090 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T160 74339-74344 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T161 74346-74352 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T162 74412-74417 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T163 74412-74417 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T7 78-88 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T8 1320-1330 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9 2661-2672 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T10 3449-3460 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T11 4309-4322 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T12 7933-7946 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T13 8106-8121 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcriptional
T14 8128-8143 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T15 8154-8167 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T16 8168-8178 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T17 8341-8366 http://purl.obolibrary.org/obo/GO_0009048 denotes X chromosome inactivation
T18 9480-9493 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T19 10181-10191 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T20 10386-10399 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T21 10534-10544 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22 10627-10646 http://purl.obolibrary.org/obo/GO_0016571 denotes histone methylation
T23 10635-10646 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T24 10694-10707 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T25 10749-10762 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T26 10939-10952 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T27 11046-11061 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T28 11464-11477 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T29 12054-12065 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T30 12100-12110 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T31 12278-12291 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T32 12326-12345 http://purl.obolibrary.org/obo/GO_0016571 denotes Histone methylation
T33 12334-12345 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T34 12388-12398 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T35 12490-12503 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T36 12674-12685 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T37 12813-12826 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T38 12936-12949 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T39 12963-12974 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T40 13623-13644 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T41 13733-13762 http://purl.obolibrary.org/obo/GO_0003712 denotes transcriptional co-regulation
T42 13752-13762 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T43 13915-13934 http://purl.obolibrary.org/obo/GO_0006338 denotes chromatin remodeler
T44 13949-13962 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T45 14085-14095 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T46 14336-14347 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T47 14363-14374 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T48 14378-14394 http://purl.obolibrary.org/obo/GO_0009299 denotes mRNA transcripts
T49 14414-14446 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modifications
T50 14450-14463 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T51 14468-14483 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T52 14503-14518 http://purl.obolibrary.org/obo/GO_0006412 denotes translationally
T53 14616-14627 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T54 15452-15473 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T55 15519-15534 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T56 15541-15556 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T57 15567-15580 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T58 15581-15591 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T59 15620-15630 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T60 15643-15656 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T61 15658-15669 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T62 15680-15693 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T63 16076-16099 http://purl.obolibrary.org/obo/GO_0050801 denotes electrolyte homeostasis
T64 16088-16099 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T65 20774-20784 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T66 23480-23490 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T67 23564-23580 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstrictive
T68 24150-24175 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T69 24680-24699 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T70 24680-24690 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T71 24719-24744 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T72 25285-25294 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T73 25299-25318 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T74 25393-25404 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T75 25398-25404 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T76 25649-25669 http://purl.obolibrary.org/obo/GO_1990874 denotes (VSMC) proliferation
T77 26357-26382 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T78 27088-27105 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T79 27088-27097 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T80 29048-29060 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T81 29336-29348 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T82 29484-29496 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T83 29524-29534 http://purl.obolibrary.org/obo/GO_0036074 denotes metaplasia
T84 29892-29898 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T85 29926-29944 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T86 29926-29935 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T87 30013-30025 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T88 32234-32246 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T89 35299-35314 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T90 36238-36253 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T91 36556-36567 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T92 36960-36974 http://purl.obolibrary.org/obo/GO_0020012 denotes immune evasion
T93 36960-36974 http://purl.obolibrary.org/obo/GO_0051805 denotes immune evasion
T94 38448-38462 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T95 38453-38462 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T96 38909-38918 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T97 39484-39498 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T98 39489-39498 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T99 40096-40103 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T100 41175-41182 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T101 41324-41339 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T102 41869-41884 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T103 42162-42173 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T104 50061-50068 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T105 55343-55358 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T106 57605-57625 http://purl.obolibrary.org/obo/GO_0055085 denotes membrane transporter
T107 57752-57773 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T108 57820-57836 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T109 58540-58545 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T110 59220-59223 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T111 59780-59797 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T112 59780-59797 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T113 59967-59988 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T114 60005-60014 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T115 60005-60014 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T116 60053-60062 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T117 60053-60062 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T118 60079-60089 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T119 60084-60089 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T120 60099-60116 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T121 60099-60116 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T122 60141-60153 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T123 60196-60217 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T124 60207-60217 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T125 60212-60217 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T126 60639-60657 http://purl.obolibrary.org/obo/GO_0006919 denotes caspase activating
T127 60674-60683 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T128 60674-60683 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T129 60862-60867 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T130 60881-60893 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T131 61198-61207 http://purl.obolibrary.org/obo/GO_0039707 denotes viroporin
T132 62249-62255 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T133 62272-62276 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T134 62334-62347 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T135 62497-62502 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T136 62566-62575 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T137 62878-62899 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T138 63009-63021 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T139 63253-63274 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T140 63958-63985 http://purl.obolibrary.org/obo/GO_0008191 denotes metalloproteinase inhibitor
T141 64126-64141 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T142 64521-64542 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T143 64609-64624 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T144 66164-66181 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T145 66164-66181 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T146 66551-66576 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T147 67381-67397 http://purl.obolibrary.org/obo/GO_0000768 denotes cell-cell fusion
T148 67381-67397 http://purl.obolibrary.org/obo/GO_0045026 denotes cell-cell fusion
T149 67386-67397 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T150 67556-67574 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T151 68176-68204 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry in the host cell
T152 69759-69766 http://purl.obolibrary.org/obo/GO_0071626 denotes chewing
T153 69821-69833 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T154 69864-69883 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T155 70018-70033 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T156 70376-70393 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T157 70384-70393 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T158 70503-70526 http://purl.obolibrary.org/obo/GO_0080144 denotes amino acids homeostasis
T159 70515-70526 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T160 70571-70591 http://purl.obolibrary.org/obo/GO_0006865 denotes amino acid transport
T161 70582-70591 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T162 70681-70705 http://purl.obolibrary.org/obo/GO_0019222 denotes regulation of metabolism
T163 70681-70691 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T164 70695-70705 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T165 70731-70742 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T166 70813-70830 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T167 70821-70830 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T168 71302-71313 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T169 71307-71313 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T170 71331-71343 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T171 71760-71766 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T172 71795-71807 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T173 72031-72064 http://purl.obolibrary.org/obo/GO_0001837 denotes epithelial-mesenchymal transition
T174 72631-72644 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T175 72898-72911 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T176 72976-72989 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T177 73132-73145 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T178 73303-73316 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T179 73342-73353 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T180 73401-73412 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T181 73468-73479 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T182 73633-73644 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T183 73992-74005 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T184 74398-74426 http://purl.obolibrary.org/obo/GO_0008217 denotes regulation of blood pressure
T185 74398-74408 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T186 74446-74457 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T187 74643-74662 http://purl.obolibrary.org/obo/GO_0042107 denotes cytokine metabolism
T188 74652-74662 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 377-399 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T4 423-435 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 440-464 Phenotype denotes congestive heart failure http://purl.obolibrary.org/obo/HP_0001635
T6 1374-1386 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 1506-1518 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 2727-2750 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T9 4047-4055 Phenotype denotes lymphoma http://purl.obolibrary.org/obo/HP_0002665
T10 4435-4448 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T11 4649-4671 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T12 5589-5601 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 5606-5628 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T14 12203-12215 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T15 12239-12263 Phenotype denotes obstructive lung disease http://purl.obolibrary.org/obo/HP_0006536
T16 24032-24051 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T17 25126-25140 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T18 25902-25923 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T19 25925-25927 Phenotype denotes MI http://purl.obolibrary.org/obo/HP_0001658
T20 26196-26218 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T21 26919-26925 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T22 27433-27446 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T30 28714-28726 Phenotype denotes pancreatitis http://purl.obolibrary.org/obo/HP_0001733
T31 28884-28894 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T32 28935-28941 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T33 29020-29026 Phenotype denotes oedema http://purl.obolibrary.org/obo/HP_0000969
T34 29429-29435 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T23 27698-27710 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T24 28343-28355 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T25 28457-28475 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T26 28487-28499 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T27 28511-28531 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T28 28689-28695 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T29 28702-28712 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T35 29680-29686 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T36 29829-29843 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T37 30185-30199 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T38 30887-30908 Phenotype denotes respiratory infective http://purl.obolibrary.org/obo/HP_0011947
T39 31960-31965 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T40 31974-31996 Phenotype denotes respiratory impairment http://purl.obolibrary.org/obo/HP_0002093
T41 32002-32011 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T42 51615-51627 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T43 51629-51652 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T44 51664-51681 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T45 52039-52051 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T46 52082-52105 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T47 52255-52267 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T48 52277-52299 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T49 52689-52701 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T50 52803-52815 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T51 52843-52865 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T52 52972-52991 Phenotype denotes acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T53 53012-53017 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T54 53246-53253 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T55 53336-53343 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T56 55156-55168 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T57 55579-55591 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T58 55593-55615 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T59 56235-56255 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T60 56629-56641 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T61 58233-58242 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T62 58533-58545 Phenotype denotes sudden death http://purl.obolibrary.org/obo/HP_0001699
T63 59035-59044 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T64 59478-59492 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T65 59628-59642 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T66 61070-61084 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T67 61499-61510 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T68 61540-61549 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T69 62739-62753 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T70 64912-64932 Phenotype denotes vitamin D deficiency http://purl.obolibrary.org/obo/HP_0100512
T71 65431-65451 Phenotype denotes pulmonary infections http://purl.obolibrary.org/obo/HP_0006532
T72 65508-65530 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T73 65637-65651 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T74 70852-70859 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T75 70964-70988 Phenotype denotes increased blood pressure http://purl.obolibrary.org/obo/HP_0032263
T76 71070-71087 Phenotype denotes Alzheimer disease http://purl.obolibrary.org/obo/HP_0002511
T77 71261-71267 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T78 71295-71301 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T79 71432-71444 Phenotype denotes colon cancer http://purl.obolibrary.org/obo/HP_0003003
T80 71501-71525 Phenotype denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/HP_0001402
T81 71754-71759 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T82 71811-71837 Phenotype denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/HP_0030358
T83 72140-72151 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T84 72403-72409 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T85 72507-72513 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T86 72733-72742 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T87 72751-72776 Phenotype denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/HP_0006725
T88 72850-72869 Phenotype denotes lung adenocarcinoma http://purl.obolibrary.org/obo/HP_0030078
T89 72934-72957 Phenotype denotes squamous cell carcinoma http://purl.obolibrary.org/obo/HP_0002860
T90 73054-73071 Phenotype denotes thyroid carcinoma http://purl.obolibrary.org/obo/HP_0002890
T91 73073-73077 Phenotype denotes THCA http://purl.obolibrary.org/obo/HP_0002890
T92 73832-73837 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T93 73952-73973 Phenotype denotes endometrial carcinoma http://purl.obolibrary.org/obo/HP_0012114

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T7 78-88 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T8 1320-1330 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9 2661-2672 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T10 3449-3460 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T11 4309-4322 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T12 7933-7946 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T13 8106-8121 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcriptional
T14 8128-8143 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T15 8154-8167 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T16 8168-8178 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T17 8341-8366 http://purl.obolibrary.org/obo/GO_0009048 denotes X chromosome inactivation
T18 9480-9493 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T19 10181-10191 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T20 10386-10399 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T21 10534-10544 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22 10627-10646 http://purl.obolibrary.org/obo/GO_0016571 denotes histone methylation
T23 10635-10646 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T24 10694-10707 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T25 10749-10762 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T26 10939-10952 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T27 11046-11061 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T28 11464-11477 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T29 12054-12065 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T30 12100-12110 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T31 12278-12291 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T32 12326-12345 http://purl.obolibrary.org/obo/GO_0016571 denotes Histone methylation
T33 12334-12345 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T34 12388-12398 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T35 12490-12503 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T36 12670-12685 http://purl.obolibrary.org/obo/GO_0006306 denotes DNA methylation
T37 12674-12685 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T38 12813-12826 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T39 12936-12949 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T40 12963-12974 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T41 13623-13644 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T42 13733-13762 http://purl.obolibrary.org/obo/GO_0003712 denotes transcriptional co-regulation
T43 13752-13762 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T44 13915-13934 http://purl.obolibrary.org/obo/GO_0006338 denotes chromatin remodeler
T45 13949-13969 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T46 13949-13962 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T47 14085-14095 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T48 14336-14347 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T49 14363-14374 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T50 14378-14394 http://purl.obolibrary.org/obo/GO_0009299 denotes mRNA transcripts
T51 14414-14446 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modifications
T52 14450-14463 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T53 14468-14483 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T54 14503-14518 http://purl.obolibrary.org/obo/GO_0006412 denotes translationally
T55 14616-14627 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T56 15452-15473 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T57 15519-15534 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T58 15541-15556 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T59 15567-15580 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T60 15581-15591 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T61 15620-15630 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T62 15643-15656 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T63 15658-15669 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T64 15680-15693 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T65 16076-16099 http://purl.obolibrary.org/obo/GO_0050801 denotes electrolyte homeostasis
T66 16088-16099 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T67 20774-20784 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T68 23480-23490 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T69 23564-23580 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstrictive
T70 24150-24175 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T71 24680-24699 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T72 24680-24690 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T73 24719-24744 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T74 25285-25294 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T75 25299-25318 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T76 25393-25404 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T77 25398-25404 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T78 25571-25583 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T79 25649-25669 http://purl.obolibrary.org/obo/GO_1990874 denotes (VSMC) proliferation
T80 26357-26382 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T81 27088-27105 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T82 27088-27097 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T83 29048-29060 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T84 29336-29348 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T85 29484-29496 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T86 29524-29534 http://purl.obolibrary.org/obo/GO_0036074 denotes metaplasia
T87 29892-29898 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T88 29926-29944 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T89 29926-29935 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T90 30013-30025 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T91 32234-32246 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T92 35299-35314 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T93 36238-36253 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T94 36556-36567 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T95 36960-36974 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T96 38448-38462 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T97 38453-38462 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T98 38909-38918 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T99 39484-39498 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T100 39489-39498 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T101 40096-40103 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T102 41175-41182 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T103 41324-41339 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T104 41869-41884 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T105 42162-42173 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T106 50061-50068 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T107 55343-55358 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T108 57605-57625 http://purl.obolibrary.org/obo/GO_0055085 denotes membrane transporter
T109 57752-57773 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T110 57820-57836 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T111 59780-59797 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T112 59780-59797 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T113 59967-59988 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T114 60005-60014 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T115 60005-60014 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T116 60019-60029 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T117 60053-60062 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T118 60053-60062 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T119 60079-60089 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T120 60099-60116 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T121 60099-60116 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T122 60141-60153 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T123 60164-60174 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T124 60196-60217 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T125 60207-60217 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T126 60316-60326 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T127 60639-60657 http://purl.obolibrary.org/obo/GO_0006919 denotes caspase activating
T128 60674-60683 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T129 60674-60683 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T130 60862-60867 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T131 60881-60893 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T132 61130-61140 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T133 61198-61207 http://purl.obolibrary.org/obo/GO_0039707 denotes viroporin
T134 61349-61359 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T135 61625-61635 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T136 62249-62255 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T137 62272-62276 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T138 62334-62354 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T139 62334-62347 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T140 62497-62502 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T141 62566-62575 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T142 62878-62899 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T143 63009-63021 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T144 63253-63274 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T145 63958-63985 http://purl.obolibrary.org/obo/GO_0008191 denotes metalloproteinase inhibitor
T146 64126-64141 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T147 64521-64542 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T148 64609-64624 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T149 66164-66181 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T150 66164-66181 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T151 66551-66576 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T152 67381-67397 http://purl.obolibrary.org/obo/GO_0140253 denotes cell-cell fusion
T153 67381-67397 http://purl.obolibrary.org/obo/GO_0045026 denotes cell-cell fusion
T154 67386-67397 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T155 67386-67397 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T156 68176-68204 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry in the host cell
T157 69759-69766 http://purl.obolibrary.org/obo/GO_0071626 denotes chewing
T158 69821-69833 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T159 69864-69883 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T160 70018-70033 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T161 70376-70393 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T162 70384-70393 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T163 70503-70526 http://purl.obolibrary.org/obo/GO_0080144 denotes amino acids homeostasis
T164 70515-70526 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T165 70571-70591 http://purl.obolibrary.org/obo/GO_0006865 denotes amino acid transport
T166 70582-70591 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T167 70681-70705 http://purl.obolibrary.org/obo/GO_0019222 denotes regulation of metabolism
T168 70681-70691 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T169 70695-70705 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T170 70723-70742 http://purl.obolibrary.org/obo/GO_0042593 denotes glucose homeostasis
T171 70731-70742 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T172 70813-70830 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T173 70821-70830 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T174 71302-71313 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T175 71307-71313 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T176 71331-71343 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T177 71760-71766 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T178 71795-71807 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T179 72031-72064 http://purl.obolibrary.org/obo/GO_0001837 denotes epithelial-mesenchymal transition
T180 72631-72644 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T181 72898-72911 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T182 72976-72989 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T183 73132-73145 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T184 73303-73316 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T185 73342-73353 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T186 73401-73412 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T187 73468-73479 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T188 73633-73644 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T189 73992-74005 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T190 74398-74426 http://purl.obolibrary.org/obo/GO_0008217 denotes regulation of blood pressure
T191 74398-74408 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T192 74446-74457 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T193 74652-74662 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T3 377-399 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T4 423-435 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 440-464 Phenotype denotes congestive heart failure http://purl.obolibrary.org/obo/HP_0001635
T6 1374-1386 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 1506-1518 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 2727-2750 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T9 4047-4055 Phenotype denotes lymphoma http://purl.obolibrary.org/obo/HP_0002665
T10 4435-4448 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T11 4649-4671 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T12 5589-5601 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 5606-5628 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T14 12203-12215 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T15 12239-12263 Phenotype denotes obstructive lung disease http://purl.obolibrary.org/obo/HP_0006536
T16 24032-24051 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T17 25126-25140 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T18 25902-25923 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T19 25925-25927 Phenotype denotes MI http://purl.obolibrary.org/obo/HP_0001658
T20 26196-26218 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T21 26919-26925 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T22 27433-27446 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T23 27698-27710 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T24 28343-28355 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T25 28432-28449 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T26 28451-28454 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T27 28457-28475 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T28 28487-28499 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T29 28511-28531 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T30 28612-28615 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T31 28689-28695 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T32 28702-28712 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T33 28714-28726 Phenotype denotes pancreatitis http://purl.obolibrary.org/obo/HP_0001733
T34 28884-28894 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T35 28935-28941 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T36 29020-29026 Phenotype denotes oedema http://purl.obolibrary.org/obo/HP_0000969
T37 29429-29435 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T38 29680-29686 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T39 29829-29843 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T40 30185-30199 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T41 30887-30908 Phenotype denotes respiratory infective http://purl.obolibrary.org/obo/HP_0011947
T42 31960-31965 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T43 31974-31996 Phenotype denotes respiratory impairment http://purl.obolibrary.org/obo/HP_0002093
T44 32002-32011 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T45 51615-51627 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T46 51629-51652 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T47 51664-51681 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T48 52039-52051 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T49 52082-52105 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T50 52255-52267 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T51 52277-52299 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T52 52689-52701 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T53 52803-52815 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T54 52843-52865 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T55 52972-52991 Phenotype denotes acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T56 53012-53017 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T57 53246-53253 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T58 53336-53343 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T59 55156-55168 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T60 55579-55591 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T61 55593-55615 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T62 56235-56255 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T63 56629-56641 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T64 58233-58242 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T65 58533-58545 Phenotype denotes sudden death http://purl.obolibrary.org/obo/HP_0001699
T66 59035-59044 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T67 59478-59492 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T68 59628-59642 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T69 61070-61084 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T70 61499-61510 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T71 61540-61549 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T72 62739-62753 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T73 64912-64932 Phenotype denotes vitamin D deficiency http://purl.obolibrary.org/obo/HP_0100512
T74 65431-65451 Phenotype denotes pulmonary infections http://purl.obolibrary.org/obo/HP_0006532
T75 65508-65530 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T76 65637-65651 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T77 67697-67714 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T78 70852-70859 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T79 70964-70988 Phenotype denotes increased blood pressure http://purl.obolibrary.org/obo/HP_0032263
T80 71070-71087 Phenotype denotes Alzheimer disease http://purl.obolibrary.org/obo/HP_0002511
T81 71261-71267 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T82 71295-71301 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T83 71432-71444 Phenotype denotes colon cancer http://purl.obolibrary.org/obo/HP_0003003
T84 71501-71525 Phenotype denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/HP_0001402
T85 71754-71759 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T86 71811-71837 Phenotype denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/HP_0030358
T87 71839-71844 Phenotype denotes NSCLC http://purl.obolibrary.org/obo/HP_0030358
T88 72068-72073 Phenotype denotes NSCLC http://purl.obolibrary.org/obo/HP_0030358
T89 72140-72151 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T90 72403-72409 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T91 72507-72513 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T92 72733-72742 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T93 72751-72776 Phenotype denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/HP_0006725
T94 72850-72869 Phenotype denotes lung adenocarcinoma http://purl.obolibrary.org/obo/HP_0030078
T95 72934-72957 Phenotype denotes squamous cell carcinoma http://purl.obolibrary.org/obo/HP_0002860
T96 73054-73071 Phenotype denotes thyroid carcinoma http://purl.obolibrary.org/obo/HP_0002890
T97 73073-73077 Phenotype denotes THCA http://purl.obolibrary.org/obo/HP_0002890
T98 73832-73837 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T99 73952-73973 Phenotype denotes endometrial carcinoma http://purl.obolibrary.org/obo/HP_0012114

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T1 10979-10981 http://rdf.glyconavi.org/CarTNa/CarTNa66/trivialname denotes H3
T2 11235-11237 http://rdf.glyconavi.org/CarTNa/CarTNa66/trivialname denotes H3
T3 12051-12053 http://rdf.glyconavi.org/CarTNa/CarTNa66/trivialname denotes H3
T4 41912-41915 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T5 41912-41915 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T6 41912-41915 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T7 41912-41915 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T8 41912-41915 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T9 41912-41915 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T10 41912-41915 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T11 41912-41915 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T12 41912-41915 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T13 41912-41915 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non
T14 44786-44789 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T15 44786-44789 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T16 44786-44789 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T17 44786-44789 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T18 44786-44789 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T19 44786-44789 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T20 44786-44789 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T21 44786-44789 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T22 44786-44789 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T23 44786-44789 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non
T24 70723-70730 http://rdf.glyconavi.org/CarTNa/CarTNa210/trivialname denotes glucose
T25 71811-71814 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T26 71811-71814 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T27 71811-71814 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T28 71811-71814 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T29 71811-71814 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T30 71811-71814 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T31 71811-71814 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T32 71811-71814 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T33 71811-71814 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T34 71811-71814 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non
T35 75872-75875 https://glytoucan.org/Structures/Glycans/G05518TD denotes All

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
98 13-42 Gene denotes Angiotensin-converting enzyme Gene:1636
99 44-47 Gene denotes ACE Gene:1636
100 162-175 Gene denotes angiotensin I Gene:183
101 180-190 Gene denotes bradykinin Gene:3827
102 238-241 Gene denotes ACE Gene:1636
103 342-345 Gene denotes ACE Gene:1636
104 478-481 Gene denotes ACE Gene:1636
105 377-399 Disease denotes cardiovascular disease MESH:D002318
106 423-435 Disease denotes hypertension MESH:D006973
107 440-464 Disease denotes congestive heart failure MESH:D006333
122 597-601 Gene denotes ACE2 Gene:59272
123 704-717 Gene denotes angiotensin I Gene:183
124 770-773 Gene denotes ACE Gene:1636
125 859-863 Gene denotes ACE2 Gene:59272
126 897-901 Gene denotes ACE2 Gene:59272
127 955-958 Gene denotes ACE Gene:1636
128 994-998 Gene denotes ACE2 Gene:59272
129 1153-1157 Gene denotes ACE2 Gene:59272
130 1294-1298 Gene denotes ACE2 Gene:59272
131 1144-1152 Gene denotes membrane Gene:43740571
132 1057-1065 Species denotes SARS-CoV Tax:694009
133 1192-1202 Species denotes SARS-CoV-2 Tax:2697049
134 563-566 Gene denotes ACE Gene:11421
135 1244-1252 Disease denotes COVID-19 MESH:C000657245
144 1549-1553 Gene denotes ACE2 Gene:59272
145 1669-1673 Gene denotes ACE2 Gene:59272
146 1689-1693 Gene denotes ACE2 Gene:59272
147 1711-1721 Species denotes SARS-CoV-2 Tax:2697049
148 1374-1386 Disease denotes Hypertension MESH:D006973
149 1432-1440 Disease denotes COVID-19 MESH:C000657245
150 1506-1518 Disease denotes hypertension MESH:D006973
151 1525-1537 Disease denotes hypertensive MESH:D006973
153 1873-1877 Gene denotes ACE2 Gene:59272
156 2076-2079 Gene denotes ACE Gene:1636
157 2091-2095 Gene denotes ACE2 Gene:59272
167 2112-2141 Gene denotes Angiotensin-converting enzyme Gene:1636
168 2143-2146 Gene denotes ACE Gene:1636
169 2318-2321 Gene denotes ACE Gene:1636
170 2323-2327 Gene denotes tACE Gene:6868
171 2471-2474 Gene denotes ACE Gene:1636
172 2294-2297 Gene denotes ACE Gene:1636
173 2424-2432 Gene denotes membrane Gene:43740571
174 2106-2111 Species denotes Human Tax:9606
175 2166-2175 Chemical denotes gluzincin
191 2591-2594 Gene denotes ACE Gene:1636
192 2839-2842 Gene denotes ACE Gene:1636
193 2968-2981 Gene denotes angiotensin I Gene:183
194 2986-2996 Gene denotes bradykinin Gene:3827
195 3032-3035 Gene denotes ACE Gene:1636
196 3129-3142 Gene denotes angiotensin I Gene:183
197 3155-3169 Gene denotes angiotensin II Gene:183
198 3255-3258 Gene denotes ACE Gene:1636
199 3301-3311 Gene denotes bradykinin Gene:3827
200 3377-3380 Gene denotes ACE Gene:1636
201 2682-2705 Chemical denotes angiotensin-aldosterone
202 2707-2711 Chemical denotes RAAS
203 3444-3448 Chemical denotes salt MESH:D012492
204 2727-2750 Disease denotes cardiovascular diseases MESH:D002318
205 3336-3347 Disease denotes hypotensive MESH:D007022
228 3499-3502 Gene denotes ACE Gene:1636
229 3778-3781 Gene denotes ACE Gene:1636
230 3937-3940 Gene denotes ACE Gene:1636
231 4149-4152 Gene denotes ACE Gene:1636
232 4477-4480 Gene denotes ACE Gene:1636
233 4496-4500 Gene denotes ACE2 Gene:59272
234 4673-4677 Gene denotes ACE2 Gene:59272
235 4750-4753 Gene denotes ACE Gene:1636
236 4781-4784 Gene denotes ACE Gene:1636
237 4786-4790 Gene denotes ACE2 Gene:59272
238 4857-4861 Gene denotes ACE2 Gene:59272
239 4946-4950 Gene denotes ACE2 Gene:59272
240 5027-5031 Gene denotes ACE2 Gene:59272
241 3569-3574 Species denotes human Tax:9606
242 3772-3777 Species denotes human Tax:9606
243 4041-4046 Species denotes human Tax:9606
244 4466-4471 Species denotes human Tax:9606
245 4627-4632 Species denotes woman Tax:9606
246 4214-4223 Chemical denotes glutamate MESH:D018698
247 4047-4055 Disease denotes lymphoma MESH:D008223
248 4435-4448 Disease denotes heart failure MESH:D006333
249 4638-4671 Disease denotes idiopathic dilated cardiomyopathy MESH:C536277
251 5144-5148 Gene denotes ACE2 Gene:59272
260 5226-5230 Gene denotes ACE2 Gene:59272
261 5305-5308 Gene denotes ACE Gene:1636
262 5364-5368 Gene denotes ACE2 Gene:59272
263 5395-5398 Gene denotes ACE Gene:1636
264 5410-5414 Gene denotes ACE2 Gene:59272
265 5484-5488 Gene denotes ACE2 Gene:59272
266 5589-5601 Disease denotes hypertension MESH:D006973
267 5606-5628 Disease denotes cardiovascular disease MESH:D002318
282 5700-5704 Gene denotes ACE2 Gene:59272
283 5849-5852 Gene denotes ACE Gene:1636
284 5857-5861 Gene denotes ACE2 Gene:59272
285 5934-5937 Gene denotes ACE Gene:1636
286 5959-5963 Gene denotes ACE2 Gene:59272
287 6029-6033 Gene denotes ACE2 Gene:59272
288 6064-6077 Gene denotes angiotensin I Gene:183
289 6081-6095 Gene denotes angiotensin II Gene:183
290 6116-6126 Gene denotes bradykinin Gene:3827
291 6138-6142 Gene denotes ACE2 Gene:59272
292 6161-6164 Gene denotes ACE Gene:1636
293 6165-6175 Chemical denotes inhibitors
294 6182-6192 Chemical denotes lisinopril MESH:D017706
295 6197-6206 Chemical denotes captopril MESH:D002216
310 6447-6451 Gene denotes ACE2 Gene:59272
311 6540-6544 Gene denotes ACE2 Gene:59272
312 6696-6700 Gene denotes ACE2 Gene:59272
313 7132-7135 Gene denotes ACE Gene:1636
314 7140-7144 Gene denotes ACE2 Gene:59272
315 7246-7250 Gene denotes ACE2 Gene:59272
316 7343-7346 Gene denotes ACE Gene:1636
317 7377-7381 Gene denotes ACE2 Gene:59272
318 7499-7503 Gene denotes ACE2 Gene:59272
319 7596-7606 Gene denotes collectrin Gene:57393
320 7564-7567 Gene denotes ACE Gene:1636
321 7682-7690 Gene denotes membrane Gene:43740571
322 7333-7339 Chemical denotes Gln281
323 7367-7373 Chemical denotes Arg273
327 7743-7747 Gene denotes ACE2 Gene:59272
328 44332-44335 Gene denotes PDB Gene:5131
329 7800-7810 Gene denotes collectrin Gene:57393
332 8149-8153 Gene denotes Post Gene:159371
333 8123-8127 Gene denotes Post Gene:159371
337 8207-8211 Gene denotes ACE2 Gene:59272
338 8270-8274 Gene denotes ACE2 Gene:59272
339 8554-8558 Gene denotes ACE2 Gene:59272
369 8952-8956 Gene denotes ACE2 Gene:59272
370 9064-9068 Gene denotes ACE2 Gene:59272
371 9202-9206 Gene denotes ACE2 Gene:59272
372 9322-9326 Gene denotes ACE2 Gene:59272
373 9381-9385 Gene denotes ACE2 Gene:59272
374 9475-9479 Gene denotes ACE2 Gene:59272
375 9580-9583 Gene denotes ACE Gene:1636
376 9623-9628 Gene denotes renin Gene:5972
377 9825-9829 Gene denotes ACE2 Gene:59272
378 9853-9856 Gene denotes ACE Gene:1636
379 9922-9925 Gene denotes ERα Gene:2099
380 10235-10266 Gene denotes Estrogen Related Receptor alpha Gene:2101
381 10268-10272 Gene denotes ERRα Gene:2101
382 10290-10293 Gene denotes ERα Gene:2099
383 10361-10365 Gene denotes ACE2 Gene:59272
384 10529-10533 Gene denotes ACE2 Gene:59272
385 8772-8777 Species denotes human Tax:9606
386 9512-9517 Species denotes human Tax:9606
387 9959-9962 Gene denotes ERα Gene:2099
388 8881-8894 Chemical denotes 17β-estradiol MESH:D004958
389 8896-8898 Chemical denotes E2 MESH:D004958
390 8922-8929 Chemical denotes steroid MESH:D013256
391 9047-9049 Chemical denotes E2 MESH:D004958
392 9462-9464 Chemical denotes E2 MESH:D004958
393 9891-9893 Chemical denotes E2 MESH:D004958
394 9294-9302 Disease denotes COVID-19 MESH:C000657245
395 9337-9357 Disease denotes SARS-CoV-2 infection MESH:C000657245
396 9390-9398 Disease denotes COVID-19 MESH:C000657245
397 9745-9762 Disease denotes myocardial stress MESH:D000079225
420 10689-10693 Gene denotes ACE2 Gene:59272
421 10766-10770 Gene denotes ACE2 Gene:59272
422 10934-10938 Gene denotes ACE2 Gene:59272
423 10972-10975 Gene denotes K27 Gene:342574
424 11158-11162 Gene denotes PRC1 Gene:9055
425 11329-11333 Gene denotes PRC1 Gene:9055
426 11599-11603 Gene denotes EZH2 Gene:2146
427 11663-11667 Gene denotes ACE2 Gene:59272
428 11688-11692 Gene denotes ACE2 Gene:59272
429 11744-11748 Gene denotes EZH2 Gene:2146
430 11812-11816 Gene denotes EZH2 Gene:2146
431 11832-11836 Gene denotes ACE2 Gene:59272
432 11909-11913 Gene denotes EZH2 Gene:2146
433 11989-11993 Gene denotes ACE2 Gene:59272
434 12114-12118 Gene denotes ACE2 Gene:59272
435 12273-12277 Gene denotes ACE2 Gene:59272
436 11707-11712 Species denotes human Tax:9606
437 12006-12011 Species denotes human Tax:9606
438 12051-12053 Chemical denotes H3 MESH:C012616
439 12203-12215 Disease denotes hypertension MESH:D006973
440 12217-12225 Disease denotes diabetes MESH:D003920
441 12231-12263 Disease denotes chronic obstructive lung disease MESH:D029424
461 12402-12406 Gene denotes ACE2 Gene:59272
462 12463-12467 Gene denotes ACE2 Gene:59272
463 12718-12722 Gene denotes ACE2 Gene:59272
464 12931-12935 Gene denotes ACE2 Gene:59272
465 13021-13025 Gene denotes ACE2 Gene:59272
466 13117-13121 Gene denotes ACE2 Gene:59272
467 13290-13294 Gene denotes ACE2 Gene:59272
468 13356-13374 Gene denotes Vitamin D receptor Gene:7421
469 13376-13379 Gene denotes VDR Gene:7421
470 13445-13449 Gene denotes ACE2 Gene:59272
471 13470-13473 Gene denotes VDR Gene:7421
472 13504-13508 Gene denotes ACE2 Gene:59272
473 13610-13614 Gene denotes ACE2 Gene:59272
474 13108-13116 Species denotes children Tax:9606
475 13648-13658 Species denotes Sars-CoV-2 Tax:2697049
476 13277-13286 Chemical denotes Vitamin D MESH:D014807
477 13579-13588 Chemical denotes Vitamin D MESH:D014807
478 12978-12984 Disease denotes tumors MESH:D009369
479 13592-13600 Disease denotes COVID-19 MESH:C000657245
487 13704-13707 Gene denotes ACE Gene:1636
488 13708-13712 Gene denotes ACE2 Gene:59272
489 13910-13914 Gene denotes Brg1 Gene:6597
490 13943-13948 Gene denotes FoxM1 Gene:2305
491 13997-14001 Gene denotes ACE2 Gene:59272
492 14002-14005 Gene denotes ACE Gene:1636
493 14043-14062 Disease denotes cardiac hypertrophy MESH:D006332
498 14220-14227 Gene denotes miR-421 Gene:693122
499 14242-14246 Gene denotes ACE2 Gene:59272
500 14289-14296 Gene denotes miR-421 Gene:693122
501 14307-14311 Gene denotes ACE2 Gene:59272
521 14485-14489 Gene denotes ACE2 Gene:59272
522 14631-14635 Gene denotes ACE2 Gene:59272
523 14707-14711 Gene denotes ACE2 Gene:59272
524 14816-14820 Gene denotes ACE2 Gene:59272
525 14967-14971 Gene denotes ACE2 Gene:59272
526 15058-15062 Gene denotes ACE2 Gene:59272
527 15114-15120 Gene denotes Ang II Gene:24179
528 15131-15137 Gene denotes ADAM17 Gene:6868
529 15173-15177 Gene denotes ACE2 Gene:59272
530 15279-15283 Gene denotes ACE2 Gene:59272
531 15398-15404 Gene denotes ADAM17 Gene:6868
532 15439-15443 Gene denotes ACE2 Gene:59272
533 15003-15013 Gene denotes calmodulin Gene:801
534 14940-14950 Gene denotes calmodulin Gene:801
535 14498-14502 Gene denotes post Gene:159371
536 14414-14418 Gene denotes post Gene:159371
537 14551-14559 Gene denotes membrane Gene:43740571
538 15477-15487 Species denotes Sars-CoV-2 Tax:2697049
539 15310-15332 Disease denotes myocardial dysfunction MESH:D009202
543 15604-15608 Gene denotes ACE2 Gene:59272
544 15562-15566 Gene denotes post Gene:159371
545 15536-15540 Gene denotes post Gene:159371
548 15706-15710 Gene denotes ACE2 Gene:59272
549 15675-15679 Gene denotes post Gene:159371
561 15830-15834 Gene denotes ACE2 Gene:59272
562 15946-15950 Gene denotes ACE2 Gene:59272
563 16173-16177 Gene denotes ACE2 Gene:59272
564 16482-16486 Gene denotes ACE2 Gene:59272
565 16962-16966 Gene denotes ACE2 Gene:59272
566 17008-17012 Gene denotes ACE2 Gene:59272
567 16151-16152 Gene denotes S Gene:43740568
568 15897-15906 Species denotes mammalian Tax:9606
569 17064-17069 Species denotes human Tax:9606
570 15983-16004 Disease denotes cardiovascular system MESH:D002318
571 17070-17085 Disease denotes hemato-lymphoid MESH:D008224
575 17341-17345 Gene denotes ACE2 Gene:59272
576 17687-17691 Gene denotes ACE2 Gene:59272
577 17674-17679 Species denotes human Tax:9606
581 17879-17883 Gene denotes ACE2 Gene:59272
582 17925-17934 Species denotes mammalian Tax:9606
583 17946-17951 Species denotes human Tax:9606
599 18551-18555 Gene denotes ACE2 Gene:59272
600 18694-18698 Gene denotes ACE2 Gene:59272
601 19122-19126 Gene denotes ACE2 Gene:59272
602 19174-19178 Gene denotes ACE2 Gene:59272
603 19336-19340 Gene denotes ACE2 Gene:70008
604 19723-19726 Gene denotes age Gene:5973
605 19643-19646 Gene denotes age Gene:5973
606 18715-18720 Species denotes human Tax:9606
607 19047-19057 Species denotes SARS-CoV-2 Tax:2697049
608 19439-19444 Species denotes mouse Tax:10090
609 19446-19449 Species denotes rat Tax:10116
610 19456-19462 Species denotes ferret Tax:9669
611 19475-19480 Species denotes human Tax:9606
612 19066-19075 Disease denotes infection MESH:D007239
613 19131-19139 Disease denotes COVID-19 MESH:C000657245
620 19793-19797 Gene denotes ACE2 Gene:59272
621 20058-20062 Gene denotes ACE2 Gene:59272
622 20470-20474 Gene denotes ACE2 Gene:59272
623 20241-20246 Disease denotes colon MESH:D003110
624 20309-20314 Disease denotes colon MESH:D003110
625 20514-20534 Disease denotes endocrine pancreatic MESH:D010195
634 20625-20629 Gene denotes ACE2 Gene:70008
635 20729-20733 Gene denotes ACE2 Gene:70008
636 21407-21411 Gene denotes ACE2 Gene:70008
637 21558-21562 Gene denotes ACE2 Gene:70008
638 20664-20669 Species denotes mouse Tax:10090
639 20686-20699 Disease denotes telencephalon
640 20928-20956 Disease denotes hypothalamic paraventricular MESH:D007027
641 20971-20979 Disease denotes postrema
648 21753-21757 Gene denotes ACE2 Gene:59272
649 21842-21846 Gene denotes ACE2 Gene:59272
650 21989-21993 Gene denotes ACE2 Gene:59272
651 21828-21833 Species denotes human Tax:9606
652 22016-22021 Species denotes human Tax:9606
653 22022-22029 Disease denotes ovaries MESH:D010051
656 22247-22251 Gene denotes ACE2 Gene:59272
657 22378-22383 Species denotes human Tax:9606
666 22465-22469 Gene denotes ACE2 Gene:59272
667 22652-22656 Gene denotes ACE2 Gene:59272
668 22762-22766 Gene denotes ACE2 Gene:59272
669 22830-22834 Gene denotes ACE2 Gene:59272
670 22999-23003 Gene denotes ACE2 Gene:59272
671 22857-22865 Gene denotes membrane Gene:43740571
672 22453-22458 Species denotes human Tax:9606
673 22869-22874 Species denotes human Tax:9606
675 23101-23105 Gene denotes ACE2 Gene:59272
688 23175-23179 Gene denotes ACE2 Gene:59272
689 23294-23298 Gene denotes ACE2 Gene:59272
690 23423-23427 Gene denotes ACE2 Gene:59272
691 23517-23521 Gene denotes ACE2 Gene:59272
692 23539-23542 Gene denotes ACE Gene:1636
693 23591-23605 Gene denotes angiotensin II Gene:183
694 23640-23644 Gene denotes ACE2 Gene:70008
695 23721-23725 Gene denotes ACE2 Gene:70008
696 23899-23902 Gene denotes ACE Gene:1636
697 24005-24009 Gene denotes ACE2 Gene:70008
698 23708-23713 Species denotes mouse Tax:10090
699 23688-23698 Species denotes transgenic Tax:10090
705 24132-24136 Gene denotes ACE2 Gene:59272
706 24250-24254 Gene denotes ACE2 Gene:59272
707 24364-24367 Gene denotes ACE Gene:1636
708 24589-24593 Gene denotes MasR Gene:116511
709 24503-24507 Gene denotes MasR Gene:116511
718 24675-24679 Gene denotes ACE2 Gene:59272
719 24701-24705 Gene denotes ACE2 Gene:59272
720 24764-24770 Gene denotes ANG II Gene:24179
721 24803-24816 Gene denotes angiotensin I Gene:183
722 24894-24897 Gene denotes ACE Gene:1636
723 25003-25007 Gene denotes ACE2 Gene:59272
724 25047-25052 Gene denotes BKB1R Gene:623
725 24916-24920 Gene denotes MasR Gene:116511
737 25164-25168 Gene denotes ACE2 Gene:59272
738 25521-25525 Gene denotes ACE2 Gene:59272
739 26097-26101 Gene denotes ACE2 Gene:59272
740 25176-25180 Gene denotes MasR Gene:116511
741 26146-26151 Species denotes human Tax:9606
742 26163-26171 Species denotes patients Tax:9606
743 25585-25597 Chemical denotes nitric oxide MESH:D009569
744 25832-25854 Disease denotes myocardial hypertrophy MESH:D006332
745 25902-25923 Disease denotes myocardial infarction MESH:D009203
746 26184-26192 Disease denotes ischemic MESH:D007511
747 26196-26218 Disease denotes dilated cardiomyopathy MESH:D002311
760 26298-26302 Gene denotes ACE2 Gene:59272
761 26352-26356 Gene denotes ACE2 Gene:59272
762 26577-26581 Gene denotes ACE2 Gene:59272
763 26744-26748 Gene denotes MrgD Gene:116512
764 26806-26810 Gene denotes MrgD Gene:116512
765 26386-26399 Chemical denotes Angiotensin A
766 26401-26406 Chemical denotes Ang-A
767 26597-26604 Chemical denotes Ala-Ang
768 26625-26635 Chemical denotes alamandine MESH:C581752
769 26861-26871 Chemical denotes alamandine MESH:C581752
770 26845-26856 Disease denotes cardiopathy MESH:C536187
771 26919-26925 Disease denotes sepsis MESH:D018805
777 26956-26959 Gene denotes ACE Gene:1636
778 26961-26965 Gene denotes ACE2 Gene:59272
779 26983-26993 Gene denotes bradykinin Gene:3827
780 27025-27035 Gene denotes bradykinin Gene:3827
781 27113-27135 Gene denotes B1 bradykinin receptor Gene:623
794 27200-27204 Gene denotes ACE2 Gene:59272
795 27227-27238 Gene denotes neurotensin Gene:4922
796 27314-27320 Gene denotes apelin Gene:8862
797 27365-27369 Gene denotes ACE2 Gene:59272
798 27491-27495 Gene denotes ACE2 Gene:59272
799 27619-27623 Gene denotes ACE2 Gene:59272
800 27628-27634 Gene denotes Apelin Gene:8862
801 27524-27530 Gene denotes apelin Gene:8862
802 27240-27251 Chemical denotes dynorphin A
803 27264-27271 Chemical denotes ghrelin MESH:D054439
804 27433-27446 Disease denotes heart failure MESH:D006333
805 27698-27710 Disease denotes hypertension MESH:D006973
811 27797-27801 Gene denotes ACE2 Gene:59272
812 27929-27932 Gene denotes ACE Gene:1636
813 28019-28023 Gene denotes MrgD Gene:116512
814 27996-28000 Gene denotes MasR Gene:116511
815 28008-28018 Chemical denotes Alamandine MESH:C581752
818 28112-28116 Gene denotes ACE2 Gene:59272
819 28121-28132 Disease denotes Lung Injury MESH:D055370
831 28133-28137 Gene denotes ACE2 Gene:59272
832 28292-28296 Gene denotes ACE2 Gene:59272
833 28390-28393 Gene denotes ACE Gene:1636
834 28398-28412 Gene denotes angiotensin II Gene:183
835 28208-28223 Disease denotes pulmonary small MESH:D008171
836 28343-28355 Disease denotes lung disease MESH:D008171
837 28432-28449 Disease denotes acute lung injury MESH:D055371
838 28457-28475 Disease denotes pulmonary fibrosis MESH:D011658
839 28477-28499 Disease denotes pulmonary hypertension MESH:D006976
840 28505-28540 Disease denotes acute respiratory distress syndrome MESH:D012128
841 28542-28546 Disease denotes ARDS MESH:D012128
858 28825-28829 Gene denotes ACE2 Gene:70008
859 29238-29242 Gene denotes ACE2 Gene:70008
860 28728-28735 Species denotes anthrax Tax:1392
861 28771-28775 Species denotes H5N1 Tax:102793
862 28839-28843 Species denotes mice Tax:10090
863 28575-28579 Disease denotes ARDS MESH:D012128
864 28649-28660 Disease denotes lung injury MESH:D055370
865 28689-28695 Disease denotes sepsis MESH:D018805
866 28714-28726 Disease denotes pancreatitis MESH:D010195
867 28740-28756 Disease denotes virus infections MESH:D001102
868 28863-28867 Disease denotes ARDS MESH:D012128
869 28935-28941 Disease denotes sepsis MESH:D018805
870 28960-28964 Disease denotes ARDS MESH:D012128
871 29015-29026 Disease denotes lung oedema MESH:D004487
872 29048-29060 Disease denotes inflammation MESH:D007249
873 29084-29118 Disease denotes impairment of respiratory function MESH:D012131
883 29310-29314 Gene denotes ACE2 Gene:59272
884 29360-29364 Gene denotes MasR Gene:116511
885 29879-29907 Gene denotes transforming growth factor β Gene:7124
886 29909-29915 Gene denotes TGF- β Gene:7039
887 29331-29348 Disease denotes lung inflammation MESH:D011014
888 29420-29435 Disease denotes allergic asthma MESH:D001249
889 29484-29496 Disease denotes inflammation MESH:D007249
890 29498-29506 Disease denotes fibrosis MESH:D005355
891 29680-29686 Disease denotes asthma MESH:D001249
900 29983-29987 Gene denotes ACE2 Gene:59272
901 30050-30055 Gene denotes BKB1R Gene:623
902 30081-30085 Gene denotes ACE2 Gene:70008
903 30201-30206 Gene denotes CXCL5 Gene:20311
904 30208-30212 Gene denotes MIP2 Gene:20310
905 30222-30227 Gene denotes TNF-α Gene:21926
906 30098-30103 Species denotes mouse Tax:10090
907 30008-30025 Disease denotes lung inflammation MESH:D011014
923 30292-30295 Gene denotes ACE Gene:1636
924 30296-30300 Gene denotes ACE2 Gene:59272
925 30392-30395 Gene denotes ACE Gene:1636
926 30409-30412 Gene denotes ACE Gene:1636
927 30443-30446 Gene denotes ACE Gene:1636
928 30470-30474 Gene denotes ACE2 Gene:59272
929 30601-30615 Gene denotes angiotensin II Gene:183
930 30285-30290 Species denotes human Tax:9606
931 30638-30646 Species denotes patients Tax:9606
932 30667-30684 Species denotes influenza viruses Tax:11308
933 30685-30689 Species denotes H5N1 Tax:102793
934 30507-30511 Disease denotes ARDS MESH:D012128
935 30531-30540 Disease denotes mortality MESH:D003643
936 30647-30655 Disease denotes infected MESH:D007239
937 30696-30698 CellLine denotes N9 CVCL:0452
940 30807-30811 Gene denotes ACE2 Gene:59272
941 30816-30824 Disease denotes COVID-19 MESH:C000657245
950 30845-30849 Gene denotes ACE2 Gene:59272
951 31709-31713 Gene denotes ACE2 Gene:59272
952 31318-31319 Gene denotes S Gene:43740568
953 31162-31173 Species denotes coronavirus Tax:11118
954 31191-31199 Species denotes SARS-CoV Tax:694009
955 30887-30916 Disease denotes respiratory infective disease MESH:D012141
956 31533-31584 Disease denotes SARS-CoV efficiently infected African Monkey kidney MESH:C000657245
957 31600-31602 CellLine denotes E6 CVCL:4582
976 32500-32504 Gene denotes ACE2 Gene:59272
977 32627-32631 Gene denotes ACE2 Gene:59272
978 31733-31741 Species denotes SARS-CoV Tax:694009
979 31862-31873 Species denotes coronavirus Tax:11118
980 31887-31892 Species denotes human Tax:9606
981 32042-32057 Species denotes new coronavirus Tax:2697049
982 32079-32089 Species denotes SARS-CoV-2 Tax:2697049
983 32123-32131 Species denotes SARS-CoV Tax:694009
984 32264-32274 Species denotes SARS-CoV-2 Tax:2697049
985 32476-32486 Species denotes SARS-CoV-2 Tax:2697049
986 32623-32626 Species denotes CoV Tax:11118
987 31797-31807 Disease denotes infections MESH:D007239
988 31960-31965 Disease denotes fever MESH:D005334
989 31974-31996 Disease denotes respiratory impairment MESH:D012131
990 32002-32011 Disease denotes pneumonia MESH:D011014
991 32189-32213 Disease denotes COronaVIrus Disease 2019 MESH:C000657245
992 32421-32429 Disease denotes COVID-19 MESH:C000657245
993 32528-32537 Disease denotes infection MESH:D007239
995 32688-32689 Gene denotes S Gene:43740568
1014 32754-32759 Gene denotes spike Gene:43740568
1015 32779-32787 Gene denotes membrane Gene:43740571
1016 32765-32773 Gene denotes envelope Gene:43740570
1017 33711-33712 Gene denotes S Gene:43740568
1018 33410-33411 Gene denotes S Gene:43740568
1019 33342-33343 Gene denotes S Gene:43740568
1020 33194-33202 Gene denotes membrane Gene:43740571
1021 32700-32711 Species denotes coronavirus Tax:11118
1022 33331-33341 Species denotes SARS-CoV-2 Tax:2697049
1023 33415-33420 Species denotes human Tax:9606
1024 33421-33429 Species denotes SARS-CoV Tax:694009
1025 33494-33504 Species denotes SARS-CoV-2 Tax:2697049
1026 33548-33556 Species denotes SARS-CoV Tax:694009
1027 33686-33694 Species denotes SARS-CoV Tax:694009
1028 33700-33710 Species denotes SARS-CoV-2 Tax:2697049
1029 33787-33795 Species denotes SARS-CoV Tax:694009
1030 33799-33809 Species denotes SARS-CoV-2 Tax:2697049
1031 33030-33046 Chemical denotes N-linked glycans
1035 33893-33904 Species denotes Coronavirus Tax:11118
1036 33972-33980 Species denotes SARS-CoV Tax:694009
1037 33985-33995 Species denotes SARS-CoV-2 Tax:2697049
1048 34224-34232 Gene denotes envelope Gene:43740570
1049 34001-34002 Gene denotes S Gene:43740568
1050 35299-35307 Gene denotes membrane Gene:43740571
1051 34995-35003 Gene denotes membrane Gene:43740571
1052 34510-34518 Species denotes SARS-CoV Tax:694009
1053 34534-34544 Species denotes SARS-CoV-2 Tax:2697049
1054 34132-34134 Gene denotes aa Gene:351
1055 34093-34095 Gene denotes aa Gene:351
1056 34936-34943 Chemical denotes glycine MESH:D005998
1057 34951-34958 Chemical denotes alanine MESH:D000409
1076 35508-35512 Gene denotes ACE2 Gene:59272
1077 35658-35662 Gene denotes ACE2 Gene:70008
1078 35848-35852 Gene denotes ACE2 Gene:59272
1079 35941-35946 Gene denotes hDPP4 Gene:1803
1080 36145-36149 Gene denotes ACE2 Gene:59272
1081 35380-35388 Species denotes SARS-CoV Tax:694009
1082 35393-35403 Species denotes SARS-CoV-2 Tax:2697049
1083 35615-35620 Species denotes human Tax:9606
1084 35638-35641 Species denotes pig Tax:9823
1085 35651-35656 Species denotes mouse Tax:10090
1086 35815-35825 Species denotes SARS-CoV-2 Tax:2697049
1087 35829-35837 Species denotes SARS-CoV Tax:694009
1088 35905-35910 Species denotes human Tax:9606
1089 35935-35939 Species denotes CoVs Tax:11118
1090 35964-35972 Species denotes MERS CoV Tax:1335626
1091 35977-35986 Species denotes HCoV-229E Tax:11137
1092 36126-36136 Species denotes SARS-CoV-2 Tax:2697049
1093 35791-35799 Disease denotes infected MESH:D007239
1097 36238-36246 Gene denotes membrane Gene:43740571
1098 36343-36351 Species denotes SARS-CoV Tax:694009
1099 36356-36366 Species denotes SARS-CoV-2 Tax:2697049
1109 37068-37069 Gene denotes S Gene:43740568
1110 36575-36576 Gene denotes S Gene:43740568
1111 38142-38146 Gene denotes post Gene:159371
1112 37640-37644 Gene denotes post Gene:159371
1113 38013-38021 Gene denotes membrane Gene:43740571
1114 36777-36785 Gene denotes membrane Gene:43740571
1115 36427-36435 Species denotes SARS-CoV Tax:694009
1116 36440-36450 Species denotes SARS-CoV-2 Tax:2697049
1117 37839-37841 Gene denotes aa Gene:351
1127 39341-39342 Gene denotes S Gene:43740568
1128 38741-38742 Gene denotes S Gene:43740568
1129 38687-38688 Gene denotes S Gene:43740568
1130 39307-39311 Gene denotes post Gene:159371
1131 39583-39591 Gene denotes membrane Gene:43740571
1132 39545-39553 Gene denotes membrane Gene:43740571
1133 39516-39524 Gene denotes membrane Gene:43740571
1134 39115-39123 Gene denotes membrane Gene:43740571
1135 38632-38643 Species denotes Coronavirus Tax:11118
1139 39922-39925 Gene denotes PDB Gene:5131
1140 39675-39676 Gene denotes S Gene:43740568
1141 39688-39698 Species denotes SARS-CoV-2 Tax:2697049
1163 39968-39972 Gene denotes ACE2 Gene:59272
1164 40813-40818 Gene denotes furin Gene:5045
1165 40895-40902 Gene denotes TMPRSS2 Gene:7113
1166 41050-41061 Gene denotes cathepsin L Gene:1514
1167 40369-40374 Gene denotes furin Gene:5045
1168 40605-40610 Gene denotes furin Gene:5045
1169 40540-40541 Gene denotes S Gene:43740568
1170 39986-39987 Gene denotes S Gene:43740568
1171 41377-41385 Gene denotes membrane Gene:43740571
1172 41324-41332 Gene denotes membrane Gene:43740571
1173 40937-40945 Gene denotes membrane Gene:43740571
1174 40069-40079 Species denotes SARS-CoV-2 Tax:2697049
1175 40143-40153 Species denotes SARS-CoV-2 Tax:2697049
1176 40177-40185 Species denotes SARS-CoV Tax:694009
1177 40207-40220 Species denotes coronaviruses Tax:11118
1178 40529-40539 Species denotes SARS-CoV-2 Tax:2697049
1179 40673-40681 Species denotes SARS-CoV Tax:694009
1180 40707-40717 Species denotes SARS-COV-2 Tax:2697049
1181 41159-41169 Species denotes SARS-CoV-2 Tax:2697049
1182 40823-40828 Gene denotes furin Gene:5045
1183 41212-41220 Disease denotes COVID-19 MESH:C000657245
1192 41807-41814 Gene denotes TMPRSS2 Gene:487770
1193 41609-41614 Gene denotes furin Gene:5045
1194 41462-41463 Gene denotes S Gene:43740568
1195 42082-42086 Gene denotes fuse Gene:2522
1196 42103-42111 Gene denotes membrane Gene:43740571
1197 42022-42030 Gene denotes membrane Gene:43740571
1198 41869-41877 Gene denotes membrane Gene:43740571
1199 41782-41790 Gene denotes membrane Gene:43740571
1201 42335-42345 Species denotes SARS-CoV-2 Tax:2697049
1217 42942-42946 Gene denotes ACE2 Gene:59272
1218 43050-43055 Gene denotes hDPP4 Gene:1803
1219 43095-43099 Gene denotes ACE2 Gene:59272
1220 43153-43157 Gene denotes ACE2 Gene:59272
1221 43031-43039 Gene denotes membrane Gene:43740571
1222 42379-42389 Species denotes SARS-CoV-2 Tax:2697049
1223 42394-42402 Species denotes SARS-CoV Tax:694009
1224 42470-42480 Species denotes SARS-CoV-2 Tax:2697049
1225 42511-42519 Species denotes SARS-CoV Tax:694009
1226 42521-42529 Species denotes SARS-CoV Tax:694009
1227 42647-42657 Species denotes SARS-CoV-2 Tax:2697049
1228 42704-42712 Species denotes SARS-CoV Tax:694009
1229 42820-42830 Species denotes SARS-CoV-2 Tax:2697049
1230 42876-42886 Species denotes SARS-CoV-2 Tax:2697049
1231 42976-42979 CellLine denotes HEK CVCL:M624
1248 43432-43434 Gene denotes β1 Gene:597
1249 43436-43438 Gene denotes β2 Gene:170589
1250 43440-43442 Gene denotes β3 Gene:28883
1251 43444-43446 Gene denotes β4 Gene:28898
1252 43448-43450 Gene denotes β7 Gene:28885
1253 43503-43505 Gene denotes β4 Gene:28898
1254 43582-43585 Gene denotes β2’ Gene:170589
1255 43574-43577 Gene denotes β1’ Gene:597
1256 43562-43564 Gene denotes β6 Gene:28873
1257 43555-43557 Gene denotes β5 Gene:28884
1258 43510-43512 Gene denotes β7 Gene:28885
1259 43207-43217 Species denotes SARS-CoV-2 Tax:2697049
1260 43314-43324 Species denotes SARS-CoV-2 Tax:2697049
1261 43744-43754 Species denotes SARS-COV-2 Tax:2697049
1262 43759-43767 Species denotes SARS-CoV Tax:694009
1263 43624-43633 Chemical denotes disulfide MESH:D004220
1271 44029-44033 Gene denotes ACE2 Gene:59272
1272 44100-44105 Gene denotes hACE2 Gene:59272
1273 43988-43993 Gene denotes spike Gene:43740568
1275 44290-44293 Gene denotes PDB Gene:5131
1276 43977-43987 Species denotes SARS-CoV-2 Tax:2697049
1277 44131-44141 Species denotes SARS-CoV-2 Tax:2697049
1301 44417-44421 Gene denotes ACE2 Gene:59272
1302 44736-44740 Gene denotes ACE2 Gene:59272
1303 45005-45009 Gene denotes ACE2 Gene:59272
1304 45237-45241 Gene denotes ACE2 Gene:59272
1305 45396-45400 Gene denotes ACE2 Gene:59272
1306 45919-45923 Gene denotes ACE2 Gene:59272
1307 45498-45499 Gene denotes S Gene:43740568
1308 45444-45445 Gene denotes S Gene:43740568
1309 44592-44593 Gene denotes S Gene:43740568
1310 44397-44407 Species denotes SARS-CoV-2 Tax:2697049
1311 44494-44504 Species denotes SARS-CoV-2 Tax:2697049
1312 44965-44975 Species denotes SARS-CoV-2 Tax:2697049
1313 45034-45042 Species denotes SARS-CoV Tax:694009
1314 45214-45224 Species denotes SARS-CoV-2 Tax:2697049
1315 45262-45272 Species denotes SARS-CoV-2 Tax:2697049
1316 45296-45304 Species denotes SARS-CoV Tax:694009
1317 45433-45443 Species denotes SARS-CoV-2 Tax:2697049
1318 45560-45570 Species denotes SARS-CoV-2 Tax:2697049
1319 45629-45637 Species denotes SARS-CoV Tax:694009
1320 45807-45817 Species denotes SARS-CoV-2 Tax:2697049
1321 45822-45830 Species denotes SARS-CoV Tax:694009
1322 45866-45876 Species denotes SARS-CoV-2 Tax:2697049
1323 46179-46189 Species denotes SARS-CoV-2 Tax:2697049
1329 46257-46262 Gene denotes spike Gene:43740568
1330 46264-46265 Gene denotes S Gene:43740568
1331 46300-46304 Gene denotes ACE2 Gene:59272
1332 46279-46280 Gene denotes S Gene:43740568
1333 46246-46256 Species denotes SARS-CoV-2 Tax:2697049
1344 46391-46392 Gene denotes S Gene:43740568
1345 46351-46352 Gene denotes S Gene:43740568
1346 46344-46350 Species denotes SARS-2 Tax:2697049
1347 46384-46390 Species denotes SARS-2 Tax:2697049
1348 46422-46428 Species denotes SARS-2 Tax:2697049
1349 46472-46478 Species denotes SARS-2 Tax:2697049
1350 46525-46531 Species denotes SARS-2 Tax:2697049
1351 46603-46629 Species denotes Shang et al., 2020b SARS-2 Tax:2697049
1352 46690-46696 Species denotes SARS-2 Tax:2697049
1353 46575-46596 CellLine denotes SARS-2 S319–529 44.2 CVCL:Z232
1355 46774-46778 Gene denotes ACE2 Gene:59272
1360 46863-46867 Gene denotes ACE2 Gene:59272
1361 47044-47048 Gene denotes ACE2 Gene:59272
1362 46933-46941 Species denotes SARS-CoV Tax:694009
1363 47057-47065 Species denotes SARS-CoV Tax:694009
1404 47307-47311 Gene denotes ACE2 Gene:59272
1405 47763-47767 Gene denotes ACE2 Gene:59272
1406 47828-47832 Gene denotes ACE2 Gene:59272
1407 47981-47985 Gene denotes ACE2 Gene:59272
1408 48003-48007 Gene denotes ACE2 Gene:59272
1409 48202-48206 Gene denotes ACE2 Gene:59272
1410 48644-48646 Gene denotes β5 Gene:28884
1411 48800-48804 Gene denotes ACE2 Gene:59272
1412 49000-49004 Gene denotes ACE2 Gene:59272
1413 49244-49248 Gene denotes ACE2 Gene:59272
1414 49330-49334 Gene denotes ACE2 Gene:59272
1415 49446-49450 Gene denotes ACE2 Gene:59272
1416 49613-49617 Gene denotes ACE2 Gene:59272
1417 49809-49813 Gene denotes ACE2 Gene:59272
1418 48128-48129 Gene denotes S Gene:43740568
1419 47855-47856 Gene denotes S Gene:43740568
1420 47729-47730 Gene denotes S Gene:43740568
1421 47624-47625 Gene denotes S Gene:43740568
1422 48327-48329 Gene denotes β6 Gene:28873
1423 48320-48322 Gene denotes β5 Gene:28884
1424 47236-47246 Species denotes SARS-CoV-2 Tax:2697049
1425 47312-47322 Species denotes SARS-CoV-2 Tax:2697049
1426 47986-47994 Species denotes SARS-CoV Tax:694009
1427 48008-48018 Species denotes SARS-CoV-2 Tax:2697049
1428 48083-48093 Species denotes SARS-CoV-2 Tax:2697049
1429 48153-48161 Species denotes SARS-CoV Tax:694009
1430 48754-48764 Species denotes SARS-CoV-2 Tax:2697049
1431 48769-48777 Species denotes SARS-CoV Tax:694009
1432 48806-48814 Species denotes SARS-CoV Tax:694009
1433 48893-48903 Species denotes SARS-CoV-2 Tax:2697049
1434 49085-49095 Species denotes SARS-CoV-2 Tax:2697049
1435 49462-49472 Species denotes SARS-CoV-2 Tax:2697049
1436 49598-49608 Species denotes SARS-CoV-2 Tax:2697049
1437 48836-48847 Chemical denotes Pro-Pro-Ala MESH:C027789
1438 48874-48889 Chemical denotes Gly-Val-Glu-Gly
1439 49021-49026 Chemical denotes Ser19
1440 49031-49036 Chemical denotes Gln24
1441 49075-49081 Chemical denotes Phe486
1442 49235-49240 Chemical denotes Tyr83
1443 49270-49276 Chemical denotes Asn501
1454 49877-49889 Gene denotes RBD-receptor
1455 50231-50235 Gene denotes ACE2 Gene:480847
1456 50407-50411 Gene denotes ACE2 Gene:59272
1457 50405-50406 Gene denotes S Gene:43740568
1458 50288-50289 Gene denotes S Gene:43740568
1459 50211-50215 Species denotes cats Tax:9685
1460 50220-50224 Species denotes dogs Tax:9615
1461 50277-50287 Species denotes SARS-CoV-2 Tax:2697049
1462 50312-50320 Disease denotes COVID-19 MESH:C000657245
1463 50321-50330 Disease denotes infection MESH:D007239
1484 50515-50519 Gene denotes ACE2 Gene:59272
1485 50804-50807 Gene denotes ACE Gene:1636
1486 50954-50958 Gene denotes ACE2 Gene:59272
1487 51144-51148 Gene denotes ACE2 Gene:59272
1488 51204-51208 Gene denotes ACE2 Gene:59272
1489 51258-51262 Gene denotes ACE2 Gene:59272
1490 50460-50465 Species denotes human Tax:9606
1491 50466-50469 Species denotes CoV Tax:11118
1492 50471-50480 Species denotes hCoV-NL63 Tax:277944
1493 50627-50637 Species denotes SARS-CoV-2 Tax:2697049
1494 50683-50692 Species denotes hCoV-NL63 Tax:277944
1495 50715-50723 Species denotes SARS-CoV Tax:694009
1496 50866-50876 Species denotes SARS-CoV-2 Tax:2697049
1497 50901-50905 Species denotes CoVs Tax:11118
1498 51043-51052 Species denotes novel CoV Tax:2697049
1499 51068-51074 Species denotes humans Tax:9606
1500 51134-51138 Species denotes CoVs Tax:11118
1501 51194-51197 Species denotes CoV Tax:11118
1502 51301-51311 Species denotes SARS-CoV-2 Tax:2697049
1503 51372-51375 Species denotes CoV Tax:11118
1505 51426-51430 Gene denotes ACE2 Gene:59272
1536 51499-51507 Species denotes patients Tax:9606
1537 51957-51965 Species denotes patients Tax:9606
1538 52625-52633 Species denotes patients Tax:9606
1539 53365-53373 Species denotes patients Tax:9606
1540 53404-53414 Species denotes SARS-CoV-2 Tax:2697049
1541 51490-51498 Disease denotes COVID-19 MESH:C000657245
1542 51615-51627 Disease denotes hypertension MESH:D006973
1543 51629-51652 Disease denotes cardiovascular diseases MESH:D002318
1544 51657-51681 Disease denotes type-2 diabetes mellitus MESH:D003924
1545 51948-51956 Disease denotes infected MESH:D007239
1546 52039-52051 Disease denotes hypertension MESH:D006973
1547 52061-52069 Disease denotes diabetes MESH:D003920
1548 52082-52105 Disease denotes cardiovascular diseases MESH:D002318
1549 52255-52267 Disease denotes hypertension MESH:D006973
1550 52277-52299 Disease denotes cardiovascular disease MESH:D002318
1551 52467-52475 Disease denotes COVID-19 MESH:C000657245
1552 52689-52701 Disease denotes hypertension MESH:D006973
1553 52706-52715 Disease denotes mortality MESH:D003643
1554 52803-52815 Disease denotes hypertension MESH:D006973
1555 52823-52831 Disease denotes diabetes MESH:D003920
1556 52843-52865 Disease denotes cardiovascular disease MESH:D002318
1557 52898-52906 Disease denotes Diabetes MESH:D003920
1558 52954-52958 Disease denotes ARDS MESH:D012128
1559 52972-52991 Disease denotes acute kidney injury MESH:D058186
1560 53005-53017 Disease denotes septic shock MESH:D012772
1561 53045-53054 Disease denotes mortality MESH:D003643
1562 53216-53225 Disease denotes mortality MESH:D003643
1563 53309-53317 Disease denotes COVID-19 MESH:C000657245
1564 53336-53343 Disease denotes obesity MESH:D009765
1565 53547-53556 Disease denotes mortality MESH:D003643
1571 53816-53820 Gene denotes ACE2 Gene:59272
1572 53977-53981 Gene denotes ACE2 Gene:59272
1573 54111-54121 Species denotes SARS-CoV-2 Tax:2697049
1574 53647-53659 Disease denotes hypertensive MESH:D006973
1575 54019-54037 Disease denotes SARS-CoV infection MESH:C000657245
1581 55086-55089 Gene denotes ACE Gene:1636
1582 54207-54217 Species denotes SARS-CoV-2 Tax:2697049
1583 55137-55145 Species denotes patients Tax:9606
1584 55156-55168 Disease denotes hypertension MESH:D006973
1585 55193-55214 Disease denotes coronavirus infection MESH:D018352
1595 55425-55429 Gene denotes ACE2 Gene:59272
1596 55484-55488 Gene denotes ACE2 Gene:59272
1597 55491-55495 Gene denotes ACE2 Gene:59272
1598 55642-55646 Gene denotes ACE2 Gene:59272
1599 55702-55712 Species denotes SARS-CoV-2 Tax:2697049
1600 55343-55358 Disease denotes viral infection MESH:D001102
1601 55579-55591 Disease denotes hypertension MESH:D006973
1602 55593-55615 Disease denotes cardiovascular disease MESH:D002318
1603 55620-55628 Disease denotes diabetes MESH:D003920
1611 55900-55904 Gene denotes ACE2 Gene:59272
1612 56071-56075 Gene denotes ACE2 Gene:59272
1613 56192-56196 Gene denotes ACE2 Gene:59272
1614 55921-55929 Gene denotes membrane Gene:43740571
1615 55946-55966 Disease denotes SARS-CoV-2 infection MESH:C000657245
1616 56127-56136 Disease denotes infection MESH:D007239
1617 56235-56255 Disease denotes respiratory distress MESH:D012128
1622 56602-56610 Species denotes patients Tax:9606
1623 56616-56624 Disease denotes COVID-19 MESH:C000657245
1624 56629-56641 Disease denotes hypertension MESH:D006973
1625 56730-56739 Disease denotes mortality MESH:D003643
1630 57003-57011 Species denotes patients Tax:9606
1631 57121-57129 Species denotes patients Tax:9606
1632 57017-57025 Disease denotes COVID-19 MESH:C000657245
1633 57135-57143 Disease denotes COVID-19 MESH:C000657245
1645 57425-57429 Gene denotes ACE2 Gene:59272
1646 57454-57458 Gene denotes ACE2 Gene:59272
1647 57587-57591 Gene denotes ACE2 Gene:59272
1648 57626-57630 Gene denotes SIT1 Gene:27240
1649 57382-57387 Species denotes human Tax:9606
1650 57516-57521 Species denotes human Tax:9606
1651 57522-57530 Species denotes patients Tax:9606
1652 57605-57613 Gene denotes membrane Gene:43740571
1653 57358-57378 Disease denotes SARS-CoV-2 infection MESH:C000657245
1654 57668-57676 Disease denotes COVID-19 MESH:C000657245
1655 57716-57728 Disease denotes hypertensive MESH:D006973
1657 57739-57743 Gene denotes ACE2 Gene:59272
1673 58054-58062 Species denotes patients Tax:9606
1674 58651-58659 Species denotes patients Tax:9606
1675 57820-57836 Disease denotes viral infections MESH:D001102
1676 57838-57845 Disease denotes COVID19 MESH:C000657245
1677 57973-57977 Disease denotes ARDS MESH:D012128
1678 57995-58006 Disease denotes lung injury MESH:D055370
1679 58109-58113 Disease denotes ARDS MESH:D012128
1680 58179-58187 Disease denotes COVID-19 MESH:C000657245
1681 58233-58242 Disease denotes pneumonia MESH:D011014
1682 58272-58292 Disease denotes microvascular damage MESH:D017566
1683 58441-58467 Disease denotes cardiovascular involvement MESH:D002318
1684 58511-58528 Disease denotes myocardial injury MESH:D009202
1685 58533-58545 Disease denotes sudden death MESH:D003645
1686 58575-58584 Disease denotes infection MESH:D007239
1687 58642-58650 Disease denotes COVID-19 MESH:C000657245
1703 59199-59204 Gene denotes IL-1β Gene:3552
1704 59206-59211 Gene denotes IFN-γ Gene:3458
1705 59213-59218 Gene denotes IP-10 Gene:3627
1706 59220-59225 Gene denotes MCP-1 Gene:6347
1707 59227-59231 Gene denotes IL-4 Gene:3565
1708 59237-59242 Gene denotes IL-10 Gene:3586
1709 58951-58959 Species denotes patients Tax:9606
1710 59065-59073 Species denotes patients Tax:9606
1711 59151-59159 Species denotes patients Tax:9606
1712 59263-59269 Species denotes people Tax:9606
1713 59285-59293 Species denotes patients Tax:9606
1714 58896-58905 Disease denotes infection MESH:D007239
1715 59022-59030 Disease denotes COVID-19 MESH:C000657245
1716 59035-59044 Disease denotes pneumonia MESH:D011014
1717 59074-59078 Disease denotes ARDS MESH:D012128
1725 59659-59663 Gene denotes ACE2 Gene:59272
1726 59747-59751 Gene denotes ACE2 Gene:59272
1727 60595-60600 Gene denotes NLRP3 Gene:114548
1728 60763-60772 Gene denotes caspase 1 Gene:834
1729 60537-60545 Gene denotes membrane Gene:43740571
1730 60141-60153 Disease denotes inflammation MESH:D007249
1731 60881-60893 Disease denotes inflammation MESH:D007249
1734 61020-61024 Gene denotes ACE2 Gene:59272
1735 61089-61099 Species denotes SARS-CoV-2 Tax:2697049
1746 61225-61230 Gene denotes NLRP3 Gene:114548
1747 61296-61301 Gene denotes IL-1β Gene:3552
1748 61431-61436 Gene denotes IL-1β Gene:3552
1749 61335-61343 Species denotes patients Tax:9606
1750 61108-61128 Disease denotes SARS-CoV-2 infection MESH:C000657245
1751 61326-61334 Disease denotes COVID-19 MESH:C000657245
1752 61483-61494 Disease denotes leucopoenia
1753 61499-61510 Disease denotes lymphopenia MESH:D008231
1754 61531-61549 Disease denotes COVID-19 pneumonia MESH:C000657245
1755 61604-61635 Disease denotes lymphocyte injury by pyroptosis MESH:D015451
1771 61737-61740 Gene denotes ACE Gene:1636
1772 61741-61745 Gene denotes ACE2 Gene:59272
1773 61809-61813 Gene denotes ACE2 Gene:59272
1774 62084-62088 Gene denotes AT1R Gene:185
1775 62142-62149 Gene denotes ADAM 17 Gene:6868
1776 62165-62169 Gene denotes TNFα Gene:7124
1777 62186-62190 Gene denotes TACE Gene:6868
1778 62272-62276 Gene denotes EGFR Gene:1956
1779 62282-62286 Gene denotes TNFα Gene:7124
1780 62432-62439 Gene denotes ADAM 17 Gene:6868
1781 62497-62503 Gene denotes IL-6Rα Gene:3570
1782 62515-62519 Gene denotes IL-6 Gene:3569
1783 62520-62525 Gene denotes STAT3 Gene:6774
1784 62834-62849 Gene denotes angiotensinogen Gene:183
1785 61723-61733 Species denotes SARS-CoV-2 Tax:2697049
1803 62952-62956 Gene denotes ACE2 Gene:59272
1804 63041-63045 Gene denotes ACE2 Gene:59272
1805 63171-63175 Gene denotes ACE2 Gene:59272
1806 63295-63302 Gene denotes ADAM 17 Gene:6868
1807 63345-63349 Gene denotes TNFα Gene:7124
1808 63409-63413 Gene denotes ACE2 Gene:59272
1809 63587-63591 Gene denotes ACE2 Gene:59272
1810 63822-63826 Gene denotes ACE2 Gene:59272
1811 63895-63901 Gene denotes ADAM17 Gene:6868
1812 63532-63537 Species denotes human Tax:9606
1813 63581-63586 Species denotes human Tax:9606
1814 63372-63380 Gene denotes membrane Gene:43740571
1815 63621-63646 Chemical denotes phorbol myristate acetate MESH:D013755
1816 63009-63021 Disease denotes inflammation MESH:D007249
1817 63538-63554 Disease denotes embryonic kidney MESH:D007674
1818 63562-63568 CellLine denotes HEK293 CVCL:0045
1819 63593-63601 CellLine denotes HEK-ACE2 CVCL:L310
1829 64049-64053 Gene denotes ACE2 Gene:59272
1830 64195-64199 Gene denotes ACE2 Gene:59272
1831 64337-64342 Gene denotes IL-1β Gene:3552
1832 64398-64402 Gene denotes ACE2 Gene:59272
1833 64565-64569 Gene denotes ACE2 Gene:59272
1834 64647-64653 Gene denotes ADAM17 Gene:6868
1835 64718-64728 Species denotes SARS-CoV-2 Tax:2697049
1836 64126-64141 Disease denotes viral infection MESH:D001102
1837 64609-64624 Disease denotes viral infection MESH:D001102
1849 64886-64896 Species denotes SARS-CoV-2 Tax:2697049
1850 65274-65284 Species denotes SARS-CoV-2 Tax:2697049
1851 65317-65327 Species denotes SARS-CoV-2 Tax:2697049
1852 65690-65700 Species denotes SARS-CoV-2 Tax:2697049
1853 64912-64921 Chemical denotes vitamin D MESH:D014807
1854 65046-65061 Disease denotes hypovitaminosis
1855 65089-65097 Disease denotes COVID-19 MESH:C000657245
1856 65409-65424 Disease denotes hypovitaminosis
1857 65431-65451 Disease denotes pulmonary infections MESH:D012141
1858 65508-65530 Disease denotes respiratory infections MESH:D012141
1859 65715-65724 Disease denotes mortality MESH:D003643
1861 65791-65795 Gene denotes ACE2 Gene:59272
1868 65843-65847 Gene denotes ACE2 Gene:59272
1869 66020-66024 Gene denotes ACE2 Gene:59272
1870 65949-65959 Species denotes SARS-CoV-2 Tax:2697049
1871 65889-65897 Disease denotes COVID-19 MESH:C000657245
1872 66034-66043 Disease denotes infection MESH:D007239
1873 66201-66212 Disease denotes lung injury MESH:D055370
1880 66355-66359 Gene denotes ACE2 Gene:59272
1881 66434-66439 Gene denotes ACE 2 Gene:59272
1882 66495-66499 Gene denotes ACE2 Gene:59272
1883 66541-66550 Gene denotes S-protein Gene:43740568
1884 66428-66433 Species denotes human Tax:9606
1885 66369-66378 Disease denotes infection MESH:D007239
1887 66589-66593 Gene denotes ACE2 Gene:59272
1889 66636-66640 Gene denotes ACE2 Gene:59272
1891 66643-66647 Gene denotes ACE2 Gene:59272
1907 66669-66673 Gene denotes ACE2 Gene:59272
1908 67193-67197 Gene denotes ACE2 Gene:59272
1909 67445-67449 Gene denotes ACE2 Gene:59272
1910 67551-67555 Gene denotes ACE2 Gene:59272
1911 67661-67665 Gene denotes ACE2 Gene:59272
1912 67850-67854 Gene denotes ACE2 Gene:59272
1913 67054-67062 Species denotes SARS-CoV Tax:694009
1914 67276-67284 Species denotes SARS-CoV Tax:694009
1915 67734-67750 Species denotes SARS coronavirus Tax:694009
1916 67486-67495 Gene denotes S-protein Gene:43740568
1917 67141-67179 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine
1918 67181-67185 Chemical denotes NAAE
1919 67512-67516 Chemical denotes NAAE
1920 67697-67714 Disease denotes acute lung injury MESH:D055371
1921 67718-67728 Disease denotes infections MESH:D007239
1932 68011-68015 Gene denotes ACE2 Gene:59272
1933 68075-68079 Gene denotes ACE2 Gene:59272
1934 68226-68230 Gene denotes ACE2 Gene:59272
1935 68452-68483 Gene denotes angiotensin-converting enzyme 2 Gene:59272
1936 68129-68139 Species denotes SARS-CoV-2 Tax:2697049
1937 68446-68451 Species denotes human Tax:9606
1938 68496-68504 Species denotes patients Tax:9606
1939 68485-68491 Chemical denotes rhACE2
1940 68324-68335 Disease denotes lung injury MESH:D055370
1941 68510-68518 Disease denotes COVID-19 MESH:C000657245
1959 68562-68567 Gene denotes ACE 2 Gene:59272
1960 68662-68671 Gene denotes S-protein Gene:43740568
1961 69364-69369 Gene denotes hACE2 Gene:59272
1962 69517-69521 Gene denotes ACE2 Gene:59272
1963 69631-69635 Gene denotes ACE2 Gene:59272
1964 68556-68561 Species denotes human Tax:9606
1965 68825-68833 Species denotes patients Tax:9606
1966 69065-69073 Species denotes patients Tax:9606
1967 69232-69237 Species denotes human Tax:9606
1968 69265-69270 Species denotes human Tax:9606
1969 69426-69436 Species denotes SARS-CoV-2 Tax:2697049
1970 69533-69543 Species denotes SARS-CoV-2 Tax:2697049
1971 68959-68965 Chemical denotes rhACE2
1972 69145-69151 Chemical denotes rhACE2
1973 68816-68824 Disease denotes COVID-19 MESH:C000657245
1974 69079-69083 Disease denotes ARDS MESH:D012128
1975 69196-69217 Disease denotes SARS-CoV-2 infections MESH:C000657245
1979 69715-69719 Gene denotes ACE2 Gene:59272
1980 70062-70066 Gene denotes ACE2 Gene:59272
1981 70018-70033 Disease denotes viral infection MESH:D001102
1983 70145-70149 Gene denotes ACE2 Gene:59272
1992 70169-70173 Gene denotes ACE2 Gene:59272
1993 70265-70269 Gene denotes ACE2 Gene:59272
1994 70307-70317 Gene denotes collectrin Gene:57393
1995 70376-70383 Gene denotes insulin Gene:3630
1996 70430-70434 Gene denotes ACE2 Gene:59272
1997 70536-70540 Gene denotes ACE2 Gene:59272
1998 70605-70619 Species denotes gut microbiome Tax:749906
1999 70461-70478 Disease denotes Hartnup’s disease MESH:D006250
2007 70656-70660 Gene denotes ACE2 Gene:59272
2008 70779-70783 Gene denotes ACE2 Gene:59272
2009 70784-70788 Gene denotes Ang1 Gene:284
2010 70813-70820 Gene denotes insulin Gene:3630
2011 70900-70904 Gene denotes ACE2 Gene:59272
2012 70791-70795 Gene denotes MasR Gene:116511
2013 70723-70742 Disease denotes glucose homeostasis MESH:D044882
2017 71050-71054 Gene denotes ACE2 Gene:59272
2018 71118-71122 Gene denotes ACE2 Gene:59272
2019 71070-71087 Disease denotes Alzheimer disease MESH:D000544
2038 71269-71273 Gene denotes ACE2 Gene:59272
2039 71557-71561 Gene denotes ACE2 Gene:59272
2040 71624-71628 Gene denotes ACE2 Gene:59272
2041 71739-71743 Gene denotes ACE2 Gene:70008
2042 71910-71914 Gene denotes ACE2 Gene:70008
2043 71942-71952 Gene denotes E-cadherin Gene:999
2044 71996-72004 Gene denotes vimentin Gene:7431
2045 71526-71534 Species denotes patients Tax:9606
2046 71691-71696 Species denotes human Tax:9606
2047 71711-71715 Species denotes mice Tax:10090
2048 71261-71267 Disease denotes cancer MESH:D009369
2049 71295-71301 Disease denotes cancer MESH:D009369
2051 71501-71525 Disease denotes hepatocellular carcinoma MESH:D006528
2052 71754-71759 Disease denotes tumor MESH:D009369
2053 71811-71837 Disease denotes Non-Small Cell Lung Cancer MESH:D002289
2054 71839-71844 Disease denotes NSCLC MESH:D002289
2055 72068-72073 Disease denotes NSCLC MESH:D002289
2062 72311-72315 Gene denotes ACE2 Gene:59272
2063 72152-72160 Species denotes patients Tax:9606
2064 72140-72151 Disease denotes lung cancer MESH:D008175
2065 72173-72181 Disease denotes COVID-19 MESH:C000657245
2066 72294-72306 Disease denotes malignancies MESH:D009369
2067 72403-72409 Disease denotes cancer MESH:D009369
2071 72481-72485 Gene denotes ACE2 Gene:59272
2072 72568-72572 Gene denotes ACE2 Gene:59272
2073 72507-72513 Disease denotes cancer MESH:D009369
2084 72626-72630 Gene denotes ACE2 Gene:59272
2085 72893-72897 Gene denotes ACE2 Gene:59272
2086 72668-72674 Disease denotes tumors MESH:D009369
2087 72676-72696 Disease denotes colon adenocarcinoma MESH:D003110
2088 72705-72742 Disease denotes kidney renal papillary cell carcinoma MESH:C538614
2089 72751-72776 Disease denotes pancreatic adenocarcinoma MESH:D000230
2090 72785-72806 Disease denotes rectum adenocarcinoma MESH:D012004
2091 72815-72837 Disease denotes stomach adenocarcinoma MESH:D000230
2092 72850-72869 Disease denotes lung adenocarcinoma MESH:D000077192
2093 72929-72957 Disease denotes lung squamous cell carcinoma MESH:D002294
2099 72971-72975 Gene denotes ACE2 Gene:59272
2100 73017-73023 Disease denotes tumors MESH:D009369
2101 73054-73071 Disease denotes thyroid carcinoma MESH:D013964
2102 73084-73102 Disease denotes kidney chromophobe MESH:D000238
2103 73104-73108 Disease denotes KICH
2106 73127-73131 Gene denotes ACE2 Gene:59272
2107 73212-73216 Gene denotes ACE2 Gene:59272
2110 73298-73302 Gene denotes ACE2 Gene:59272
2111 73357-73361 Gene denotes ACE2 Gene:59272
2114 73530-73534 Gene denotes ACE2 Gene:59272
2115 73549-73556 Species denotes patient Tax:9606
2122 73664-73668 Gene denotes ACE2 Gene:59272
2123 73849-73853 Gene denotes ACE2 Gene:59272
2124 73987-73991 Gene denotes ACE2 Gene:59272
2125 73760-73768 Chemical denotes Oncomine
2126 73832-73837 Disease denotes tumor MESH:D009369
2127 73952-73973 Disease denotes endometrial carcinoma MESH:D016889
2135 74104-74108 Gene denotes ACE2 Gene:59272
2136 74131-74134 Gene denotes ACE Gene:1636
2137 74174-74177 Gene denotes ACE Gene:1636
2138 74327-74331 Gene denotes ACE2 Gene:59272
2139 74491-74494 Gene denotes ACE Gene:1636
2140 74585-74589 Gene denotes ACE2 Gene:59272
2141 74431-74457 Disease denotes cardiovascular homeostasis MESH:D002318
2154 74797-74801 Gene denotes ACE2 Gene:59272
2155 75052-75056 Gene denotes ACE2 Gene:59272
2156 75205-75209 Gene denotes ACE2 Gene:59272
2157 75238-75242 Gene denotes ACE2 Gene:59272
2158 75402-75406 Gene denotes ACE2 Gene:59272
2159 75564-75568 Gene denotes ACE2 Gene:59272
2160 74878-74886 Species denotes SARS-Cov Tax:694009
2161 74891-74900 Species denotes SARS-Cov2 Tax:2697049
2162 75110-75123 Species denotes coronaviruses Tax:11118
2163 74771-74779 Disease denotes COVID-19 MESH:C000657245
2164 75328-75336 Disease denotes COVID-19 MESH:C000657245
2165 75573-75581 Disease denotes COVID-19 MESH:C000657245
2167 75733-75735 Disease denotes FS MESH:D018223

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T19 0-12 Sentence denotes Introduction
T20 13-191 Sentence denotes Angiotensin-converting enzyme (ACE) has an important role in the metabolism of several peptides and proteins, including chemical messengers, such as angiotensin I and bradykinin.
T21 192-465 Sentence denotes The importance assumed by research focused on ACE biochemistry, physiology and pharmacology is closely linked to the clinical effectiveness showed by ACE inhibitors in the treatment of cardiovascular disease, particularly arterial hypertension and congestive heart failure.
T22 466-546 Sentence denotes At present, ACE inhibitors are among the most widely prescribed drugs worldwide.
T23 547-618 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 619-718 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 719-785 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 786-985 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 986-1158 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 1159-1373 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.
T29 1374-1615 Sentence denotes Hypertension has been suggested to have a major impact on COVID-19 susceptibility and prognosis, therefore the elusive link between hypertension, anti-hypertensive drugs, and ACE2 expression has soon become the object of a major controversy.
T30 1616-1795 Sentence denotes On the other hand, treatments able to interfere with ACE2 expression, or ACE2 availability for SARS-CoV-2 binding, have been identified as a novel goal of pharmaceutical research.
T31 1796-1903 Sentence denotes The purpose of the present review is to summarize the available knowledge on ACE2 biochemistry and biology.
T32 1904-2074 Sentence denotes We have also tried to point out some crucial open questions, which should be addressed to provide a better background for future experimental and clinical investigations.
T33 2076-2105 Sentence denotes ACE System and ACE2 Discovery
T34 2106-2329 Sentence denotes Human Angiotensin-converting enzyme (ACE) belongs to the M2 gluzincin family of metalloproteinases and (Ehlers and Riordan, 1989; Masuyer et al., 2014) exists in two forms, namely somatic ACE (sACE) and germinal ACE (tACE).
T35 2330-2552 Sentence denotes Both are derived from the same gene, controlled by alternative promotors. sACE is an integral membrane protein, which can be also cleaved by ACE secretases to produce a circulating form of the enzyme (Natesh et al., 2003).
T36 2553-2789 Sentence denotes sACE, hereafter referred to simply as ACE, has been extensively studied, because of its crucial role in the homeostasis of renin-angiotensin-aldosterone (RAAS) system and in cardiovascular diseases (Takimoto-Ohnishi and Murakami, 2019).
T37 2790-3023 Sentence denotes The two extracellular domains N and C domains of ACE (Wei et al., 1991; Jaspard et al., 1993; Natesh et al., 2003; Riordan, 2003) can both hydrolase two crucial peptides, namely angiotensin I and bradykinin, with the same efficiency.
T38 3024-3244 Sentence denotes Indeed, ACE carries out the cleavage of two amino acids (dipeptidase action) from the C-terminal part of angiotensin I to generate angiotensin II, which exerts a potent vasopressor, proliferative, and profibrotic effect.
T39 3245-3356 Sentence denotes Moreover, ACE mediates the cleavage and inactivation of bradykinin, which is a vasodilator hypotensive peptide.
T40 3357-3484 Sentence denotes The pivotal role of ACE in the RAAS system allows a refined blood pressure control and salt homeostasis (Sayer and Bhat, 2014).
T41 3485-3673 Sentence denotes Following the ACE discovery in mid-1950s, despite intense research in the field, no human homologs of the enzyme have been found for more than 50 years (Isaac et al., 1998; Riordan, 2003).
T42 3674-3825 Sentence denotes It was only in 2000 that two independent research groups identified, almost simultaneously, a new human ACE-like enzyme, with two different approaches.
T43 3826-4005 Sentence denotes Tipnis et al. (2000) searched for new metalloproteases in an expressed sequence tag (EST) database, finding an ACE homolog (ACEH) with a single domain, similar to that of insects.
T44 4006-4069 Sentence denotes Subsequently they cloned it from a human lymphoma cDNA library.
T45 4070-4258 Sentence denotes Interestingly ACEH showed high homology (40% identity and 60% similarity) with ACE, particularly around the HEXXH sequence and highly conserved glutamate residue, involved in zinc binding.
T46 4259-4351 Sentence denotes Moreover, they demonstrated the presence of seven glycosylation sites (Tipnis et al., 2000).
T47 4352-4672 Sentence denotes In the same year, Donoghue et al. (2000b) were searching for new genes involved in heart failure and identified a human cDNA ACE homolog, named ACE2, among 19,000 5’end sequences by RACE (rapid amplification of cDNA ends) in the heart ventricle cDNA library, obtained from a woman with idiopathic dilated cardiomyopathy.
T48 4673-4775 Sentence denotes ACE2 showed a transmembrane domain, a zinc catalytic domain 42% identical to ACE and a signal peptide.
T49 4776-4833 Sentence denotes Like ACE, ACE2 seemed to be an ectoenzyme type I protein.
T50 4834-5002 Sentence denotes The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b).
T51 5003-5142 Sentence denotes In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.
T52 5144-5149 Sentence denotes ACE2:
T53 5150-5206 Sentence denotes Structure, Expression, Tissue Distribution, and Function
T54 5208-5225 Sentence denotes Structure of ACE2
T55 5226-5347 Sentence denotes ACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17.
T56 5348-5405 Sentence denotes The 18 exons of ACE2 are remarkably similar to ACE exons.
T57 5406-5695 Sentence denotes The ACE2 gene depicts a large polymorphism and several novel polymorphisms of ACE2, with specific geographical distribution, have been described and associated with susceptibility to hypertension and cardiovascular disease (Burrell et al., 2013; Patel et al., 2014; Pinheiro et al., 2019).
T58 5696-5816 Sentence denotes The ACE2 gene codifies for a typical zinc-metallopeptidase of 805 amino acids (120 kDa), with a unique catalytic domain.
T59 5817-5927 Sentence denotes Despite the high resemblance of ACE and ACE2, considerable differences exist in their substrates and products.
T60 5928-6017 Sentence denotes While ACE acts as dipeptidase, ACE2 removes only a single amino acid from its substrates.
T61 6018-6269 Sentence denotes Therefore, ACE2 is not active in transforming angiotensin I to angiotensin II and in inactivating bradykinin; moreover, ACE2 is insensitive to ACE inhibitors, like lisinopril and captopril (Tipnis et al., 2000; Rice et al., 2004; Turner et al., 2004).
T62 6270-6367 Sentence denotes These differences depend on variances in the three-dimensional structure (3D) of the two enzymes.
T63 6368-6476 Sentence denotes Comparative homology modeling and crystallography contributed to shed light on ACE2 3D structure (Figure 1).
T64 6477-6629 Sentence denotes Prabakaran et al. (2004) clarified the major characteristic of ACE2, which is a deep channel on the summit of the protein, hosting the catalytic domain.
T65 6630-6778 Sentence denotes Specific loops, like the long loop N210-Q221 that is exclusive of ACE2, α helices and a portion of β-sheet are located around the catalytic channel.
T66 6779-6939 Sentence denotes The negative charge of the channel and the presence of distinct hydrophobic regions contribute to the specificity of the binding site (Prabakaran et al., 2004).
T67 6940-7202 Sentence denotes The determination of the crystal structure of the extracellular domain to 2.2-3-A resolution from Towler et al. (2004) and the model from Guy et al. (2003) showed that the catalytic domain of ACE and ACE2 are very conserved and have similar mechanisms of action.
T68 7203-7474 Sentence denotes The main difference stems from the smaller ACE2 pocket, thereby lodging only a single amino acid: the crucial substitution of the Gln281 in ACE binding pocket with Arg273 in ACE2 is likely to be responsible for the steric conflict (Guy et al., 2003; Towler et al., 2004).
T69 7475-7711 Sentence denotes Another surprise of the ACE2 structure was its C-terminal domain, which—differently from ACE—revealed high homology with collectrin, a renal protein, which is involved in amino acids trafficking through the membrane (Yang et al., 2017).
T70 7712-7748 Sentence denotes FIGURE 1 Crystal structure of ACE2.
T71 7749-7864 Sentence denotes The peptidase domain (PD) is in green, whereas the collectrin homology domain is enclosed in the light cyan square.
T72 7865-8010 Sentence denotes The active zinc ion is showed enclosed in a red circle, whereas the glycosylation moieties are showed as cyan cubes and denoted by dashed arrows.
T73 8011-8104 Sentence denotes The structures have been drawn from PDB 1R42 (Towler et al., 2004) by Mol on the PDB website.
T74 8106-8186 Sentence denotes Transcriptional, Post-transcriptional, and Post-translational Regulation of ACE2
T75 8187-8470 Sentence denotes The location of the ACE2 gene on the X chromosome questions whether one of the two ACE2 is silenced in females, to balance female/male expression dosage (X chromosome inactivation or XCI), or otherwise belongs to the class of “escape genes” which are transcribed on both chromosomes.
T76 8471-8659 Sentence denotes Interestingly, a wide survey of XCI in several individuals and tissues showed that ACE2 is a heterogeneous escape gene, because it has a tissue-dependent sex bias (Tukiainen et al., 2017).
T77 8660-8812 Sentence denotes A growing number of recent findings point to an important role of epigenetic mechanisms associated with several human diseases (Surguchov et al., 2017).
T78 8813-8987 Sentence denotes In this context, several authors highlighted the regulatory role of 17β-estradiol (E2), a primary female sex steroid, in the expression of ACE2 in a tissue-dependent fashion.
T79 8988-9136 Sentence denotes Liu et al. (2010) and Stelzig et al. (2020) found out that E2 downregulates ACE2 in kidney and differentiated airway epithelial cells, respectively.
T80 9137-9419 Sentence denotes The latter result is particularly important, as the male-bias of ACE2 expression in the lung could account for the alleged higher susceptibility of males to COVID-19 symptoms following ACE2-dependent SARS-CoV-2 infection (section Links Between ACE2 and COVID-19) (Jin et al., 2020).
T81 9420-9592 Sentence denotes Yet, Bukowska et al. (2017) observed that E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein.
T82 9593-9804 Sentence denotes This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to myocardial stress and contributes to antiarhythmic effects.
T83 9805-9951 Sentence denotes The upregulation of ACE2 (and downregulation of ACE) was clearly linked to binding of E2 to Estrogen Receptor alpha (ERα) (Bukowska et al., 2017).
T84 9952-10192 Sentence denotes The E2-ERα complex might migrate to the nucleus to bind to estrogen response elements, although the actual mechanism is still obscure and should likely involve other co-factors to take into account the observed tissue bias of E2 regulation.
T85 10193-10442 Sentence denotes Nonetheless, it was demonstrated that the Estrogen Related Receptor alpha (ERRα), which likewise ERα recognizes the estrogen response element in target genes, binds to ACE2 promoter to repress transcription (Tremblay et al., 2010; Lee et al., 2012).
T86 10443-10545 Sentence denotes Hopefully, future studies will shed more light on the intriguing role of estrogens in ACE2 regulation.
T87 10546-10708 Sentence denotes A recent analysis of public genomic and transcriptomic data outlined the role of histone methylation, a classical epigenetic mark, to regulate ACE2 transcription.
T88 10709-10870 Sentence denotes Indeed, Li Y. et al. (2020) showed that transcription of ACE2 was significantly upregulated when the histone mutant H3K27M was overexpressed to inhibit H3K27me3.
T89 10871-10953 Sentence denotes Conversely, overexpression of mutant H3K4/9/36M did not change ACE2 transcription.
T90 10954-11109 Sentence denotes Trimethylation of K27 on H3 is catalyzed by the polycomb groups (PcG), a group of conserved transcriptional gene repressors (Schuettengruber et al., 2017).
T91 11110-11172 Sentence denotes PcG proteins assemble into two major complexes: PRC1 and PRC2.
T92 11173-11297 Sentence denotes The simplest model of PcG activity involves trimethylation of H3 by PRC2 at target gene promoters (Blackledge et al., 2015).
T93 11298-11546 Sentence denotes These epigenetic marks recruit PRC1 on DNA, which in turn acts as E3-ligase and ubiquitinates nearby H2A histones (Storti et al., 2019), triggering silencing of gene transcription by local and reversible compaction of chromatin (Illingworth, 2019).
T94 11547-11612 Sentence denotes The catalytic subunit of PRC2 is constituted by the EZH2 protein.
T95 11613-11780 Sentence denotes In agreement with the inverse correlation between ACE2 level and H3K27me3, ACE2 expression in human ESCs was upregulated following EZH2 knock-out (Li Y. et al., 2020).
T96 11781-11844 Sentence denotes On the other side, recovery of EZH2 restored basal ACE2 levels.
T97 11845-12038 Sentence denotes Chromatin immunoprecipitation sequencing (ChIP-seq) showed that EZH2 depletion induced H3K27me3 decrease, with concomitant H3K27ac increase, at ACE2 promoter in human ESCs (Li Y. et al., 2020).
T98 12039-12325 Sentence denotes The role of H3 methylation and acetylation in the epigenetic regulation of ACE2 was also hypothesized by Pinto et al., who demonstrated that co-morbidities such as hypertension, diabetes, and chronic obstructive lung disease increase ACE2 transcription in the lung (Pinto et al., 2020).
T99 12326-12407 Sentence denotes Histone methylation does not appear to exhaust the epigenetic regulation of ACE2.
T100 12408-12556 Sentence denotes Notably, the NAD+-dependent deacetylase SIRT1 binds to ACE2 promoter favoring its transcription during cellular energy stress (Clarke et al., 2014).
T101 12557-12637 Sentence denotes Two recent unrefereed preprints highlighted other epigenetic mechanisms at play.
T102 12638-12842 Sentence denotes Corley et al.1 pointed out that DNA methylation across three CpG islands in the ACE2 promoter was lower in lung epithelial cells compared to other cell types, suggesting high transcription in lung tissue.
T103 12843-13045 Sentence denotes These findings are in excellent agreement with the reported inverse correlation between ACE2 transcription and promoter methylation in tumors, which will be discussed in section ACE2 and Other Diseases.
T104 13046-13228 Sentence denotes This correlation is also supported by the observation that in children ACE2 is normally hypermethylated and poorly expressed either in the lung and in other organs (Pruimboom, 2020).
T105 13229-13450 Sentence denotes Glinsky (2020) addressed the epigenetic role of Vitamin D on ACE2 expression, showing by gene set enrichment analysis that the Vitamin D receptor (VDR) should be involved in a set of regulatory pathways conveying on ACE2.
T106 13451-13660 Sentence denotes More specifically, VDR activation would downregulate ACE2, thus affording a potential reason for the alleged beneficial role of Vitamin D in COVID-19 (section ACE2 and the Inflammatory Response to Sars-CoV-2).
T107 13661-13780 Sentence denotes Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins.
T108 13781-14076 Sentence denotes Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart.
T109 14077-14121 Sentence denotes Further regulation occurs at the mRNA level.
T110 14122-14247 Sentence denotes From putative microRNA-binding sites identified in vitro, Lambert et al. (2014) demonstrated that miR-421 downregulates ACE2.
T111 14248-14395 Sentence denotes According to the hypothesized mechanism, miR-421 modulates ACE2 expression by hampering translation rather than by degradation of mRNA transcripts.
T112 14396-14611 Sentence denotes Beside undergoing post-translational modifications by glycosylation and phosphorylation, ACE2 is also post-translationally regulated by shedding from cell membrane through the action of the metalloproteinase ADAM17.
T113 14612-14782 Sentence denotes The proteolysis of ACE2 releases a soluble, enzymatically active form which corresponds to the ACE2 ectodomain (Jia et al., 2009; Xiao et al., 2014; Conrad et al., 2016).
T114 14783-14900 Sentence denotes The function, if any, of soluble ACE2 is still obscure, but the shedding mechanism is under strict molecular control.
T115 14901-15063 Sentence denotes Lambert et al. (2008) highlighted that calmodulin associates with ACE2 to prevent its shedding, while calmodulin inhibitors increase the cellular release of ACE2.
T116 15064-15113 Sentence denotes Patel identified a positive feedback in the RAAS:
T117 15114-15224 Sentence denotes Ang II activates ADAM17, thereby increasing the release of ACE2, its negative regulator (Patel et al., 2016b).
T118 15225-15356 Sentence denotes It is worth noting that high levels of plasma-soluble ACE2 have been associated with myocardial dysfunction (Epelman et al., 2009).
T119 15357-15488 Sentence denotes The potential pathophysiological role of ADAM17 is further discussed in paragraph ACE2 and the Inflammatory Response to Sars-CoV-2.
T120 15489-15609 Sentence denotes Figure 2 summarizes the known transcriptional, post-transcriptional, and post translational regulation pathways of ACE2.
T121 15610-15711 Sentence denotes FIGURE 2 Regulation pathways of transcription, translation, and post-translational shedding of ACE2.
T122 15712-15744 Sentence denotes Red text: non-molecular factors.
T123 15745-15775 Sentence denotes Black text: molecular factors.
T124 15777-15804 Sentence denotes Tissue Distribution of ACE2
T125 15805-15945 Sentence denotes Detectable quantities of ACE2 protein have been found almost ubiquitously in tissues across mammalian species, using immunostaining methods.
T126 15946-16163 Sentence denotes ACE2 is predominantly located in the cardiovascular system and kidney, where it probably plays a role in the maintenance of hydro electrolyte homeostasis (section “Mechanism of Viral Entry Mediated by the S Protein”).
T127 16164-16382 Sentence denotes In fact, ACE2 is pervasively expressed throughout the vasculature, at the level of the arteries and veins, mainly in smooth muscle cells of the media and in the endothelium (Hamming et al., 2004; Burrell et al., 2005).
T128 16383-16473 Sentence denotes Such signal from vessels also delivers part of the expression detected in specific organs.
T129 16474-16812 Sentence denotes Indeed, ACE2 is evident in: coronary vessels and myocardial capillaries (Wiener et al., 2007; Garabelli et al., 2008); lung microvascular endothelial cells (Wiener et al., 2007; Chen et al., 2013); kidney interlobular arteries (Lely et al., 2004); endothelial and smooth muscle cells in the brain (Hamming et al., 2004; Kar et al., 2010).
T130 16813-16990 Sentence denotes Notably, the mesangium and glomerular endothelium in the kidney, and the endothelial lining of the sinusoids in the liver are allegedly negative for ACE2 (Hamming et al., 2004).
T131 16991-17178 Sentence denotes On the contrary, ACE2 is virtually absent from the lymphatic system, and human hemato-lymphoid organs (i.e., spleen, lymph nodes, and bone marrow) (Hamming et al., 2004; Li et al., 2007).
T132 17179-17326 Sentence denotes In blood cells, it has been observed in platelets and macrophages, but not in B and T lymphocytes (Hamming et al., 2004; Fraga-Silva et al., 2011).
T133 17327-17670 Sentence denotes Expression of ACE2 was originally identified in rodent heart (Donoghue et al., 2000a), where it was observed to occur in both atrium an ventricle (Gembardt et al., 2005), and, cellularly, in cardiomyocytes and in specialized cells of the sinoatrial node (Burrell et al., 2005; Garabelli et al., 2008; Ferreira et al., 2011; Wang et al., 2017).
T134 17671-17863 Sentence denotes In human heart, ACE2 has been found in the stromal area in spongiosa layer in aortic valves (Peltonen et al., 2011), where it is expressed in myofibroblasts and fibroblasts (Guy et al., 2008).
T135 17864-18151 Sentence denotes High levels of ACE2 protein expression have been detected in mammalian, including human, kidney (Gembardt et al., 2005; Koka et al., 2008; Reich et al., 2008; Giani et al., 2012; Mitani et al., 2014; Grobe et al., 2015; Shi et al., 2015; Larouche-Lebel et al., 2019; Alawi et al., 2020).
T136 18152-18490 Sentence denotes Strong signals were reported in the brush border of the proximal tubular cells, whereas weak to moderate signals could be found in the glomeruli, Henle’s loop, distal tubules, and collecting duct (Hamming et al., 2004; Lely et al., 2004; Kamilic et al., 2010; Giani et al., 2012; Bae et al., 2015; Cao et al., 2017; Errarte et al., 2017).
T137 18491-18685 Sentence denotes In the respiratory tract of primates, positive labeling for ACE2 has been reported at multiple sites, from the nasal and oral mucosa, to the larynx, trachea, bronchi and lung (Liu et al., 2011).
T138 18686-18971 Sentence denotes Whether ACE2 is expressed in human nasal and oral epithelium remains unclear, as contradictory results have been reported by studies using immunohistochemistry (Hamming et al., 2004; Bertram et al., 2012), in face of positive single-cell RNA sequencing findings (Sungnak et al., 2020).
T139 18972-19142 Sentence denotes This point is of great interest to understand the role of those tissues in SARS-CoV-2 initial infection, spread and clearance (section “Links Between ACE2 and COVID-19”).
T140 19143-19300 Sentence denotes In the upper respiratory tract ACE2 is expressed in the epithelial lining and lamina propria, in some muscle cells and in the salivary gland duct epithelium.
T141 19301-19595 Sentence denotes In the lung, an intense signal for ACE2 protein has been consistently observed in type I and II pneumocytes in several species, including mouse, rat, cat, ferret, monkey and human (Wiener et al., 2007; van den Brand et al., 2008; Liu et al., 2011; Wong et al., 2012; Chen et al., 2013; Zhang B.
T142 19596-19613 Sentence denotes N. et al., 2019).
T143 19614-19778 Sentence denotes Data from rodents suggest an age- and gender-dependent pattern of expression, with a more rapid decline with age in males as compared to females (Xie et al., 2006).
T144 19779-20057 Sentence denotes Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020).
T145 20058-20247 Sentence denotes ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon.
T146 20248-20457 Sentence denotes Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004).
T147 20458-20624 Sentence denotes In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010).
T148 20625-20715 Sentence denotes ACE2 distribution is widespread in the mouse brain, from the telencephalon to the medulla.
T149 20716-21122 Sentence denotes As expected, ACE2 is found in brain areas involved in the regulation of cardiovascular function and fluid balance, such as the vascular organ of lamina terminalis, subfornical organ, magnocellular neurons in the hypothalamic paraventricular nucleus, area postrema, nucleus of the solitary tract, dorsal motor nucleus of the vagus, nucleus ambiguous, and rostral ventrolateral medulla (Doobay et al., 2007).
T150 21123-21406 Sentence denotes However, significant expression had also been reported in brain areas not engaged in the classical functions of the RAAS, namely the piriform cortex, hippocampus, caudate putamen, hypoglossal nucleus and primary motor cortex (Doobay et al., 2007; Lin et al., 2008; Liu et al., 2014).
T151 21407-21544 Sentence denotes ACE2 immunostaining was identified in neurons as well as astrocytes (Gallagher et al., 2006; Doobay et al., 2007; Yamazato et al., 2007).
T152 21545-21715 Sentence denotes Furthermore, ACE2 has been documented in the retina, predominantly in the inner nuclear layer but also in photoreceptors (Tikellis et al., 2004; Senanayake et al., 2007).
T153 21716-21824 Sentence denotes With regard to the endocrine system, ACE2 expression was found in both male and female reproductive systems.
T154 21825-21962 Sentence denotes In human testis, ACE2 was localized to the Leydig and Sertoli cells, and might be involved in testicular function (Douglas et al., 2004).
T155 21963-22230 Sentence denotes At present, no data about ACE2 protein expression is human ovaries is available, although evidence of expression in stroma, theca, and granulosa cells has been reported in other species (Tonellotto dos Santos et al., 2012; Barreta et al., 2015; Pereira et al., 2015).
T156 22231-22344 Sentence denotes In rodent bone, ACE2 is expressed in osteoblasts and osteoclasts, as well as in epithelial cells and fibroblasts.
T157 22345-22449 Sentence denotes However, a similar expression in human samples still awaits clarification (Queiroz-Junior et al., 2019).
T158 22450-22575 Sentence denotes In human skin, ACE2 was present in the basal cell layer of the epidermis extending to the basal cell layer of hair follicles.
T159 22576-22657 Sentence denotes Smooth muscle cells surrounding the sebaceous glands were also positive for ACE2.
T160 22658-22722 Sentence denotes Weak cytoplasmic staining was observed in sebaceous gland cells.
T161 22723-22807 Sentence denotes A strong granular staining pattern for ACE2 was seen in cells of the eccrine glands.
T162 22808-22988 Sentence denotes Positive staining for ACE2 was also noted in the membrane of human fat cells in various organs, including the epicardial adipose tissue (Hamming et al., 2004; Patel et al., 2016a).
T163 22989-23099 Sentence denotes Globally, ACE2 is chiefly bound to cell membranes, while negligible levels can be detected in the circulation.
T164 23101-23143 Sentence denotes ACE2, the RAAS System and Cardioprotection
T165 23144-23408 Sentence denotes After the initial discovery of ACE2 in the heart and kidney, it is now clear that it is widely distributed in tissues (section Tissue Distribution of ACE2), where it exerts many physiological effects and may be involved in pathophysiological events (Turner, 2015).
T166 23409-23615 Sentence denotes The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II).
T167 23616-23842 Sentence denotes The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinning of the left ventricular wall.
T168 23843-23974 Sentence denotes Interestingly, in this knockout model disruption of the ACE pathway could rescue the myocardial phenotype (Crackower et al., 2002).
T169 23975-24110 Sentence denotes In another study, a selective ACE2 knockout model showed high blood pressure, worsened by the infusion of Ang-II (Gurley et al., 2006).
T170 24111-24249 Sentence denotes As a matter of fact, ACE2 displays its carboxypeptidase activity converting Ang-II to a heptapeptide, namely Ang1–7 (Turner et al., 2004).
T171 24250-24458 Sentence denotes ACE2 can also convert angiotensin I (Ang-I) to the non apeptide Ang1–9, which is in turn converted into Ang1–7 by ACE, competing with Ang-I and thus further decreasing Ang-II (Arendse et al., 2019; Figure 3).
T172 24459-24664 Sentence denotes Ang1–7 has been demonstrated to bind to the MasR receptor, which was initially regarded as an orphan receptor, since the use of a MasR antagonist caused inhibition of Ang1–7 effects (Alenina et al., 2008).
T173 24665-24898 Sentence denotes FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE.
T174 24899-25002 Sentence denotes ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs).
T175 25003-25141 Sentence denotes ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm.
T176 25142-25493 Sentence denotes In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016).
T177 25494-25741 Sentence denotes Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008).
T178 25742-25929 Sentence denotes In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI).
T179 25930-26264 Sentence denotes In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005).
T180 26265-26330 Sentence denotes Additional players contribute to ACE2-mediated cardio-protection.
T181 26331-26525 Sentence denotes Another substrate of ACE2 carboxypeptidase activity is Angiotensin A (Ang-A), identified in 2008, which has a similar, although less potent, vasopressor effect as AngII (Jankowski et al., 2007).
T182 26526-26669 Sentence denotes The product of the enzymatic reaction catalyzed by ACE2 is the peptide Ala-Ang (1–7) also known as alamandine (Lautner et al., 2013; Figure 3).
T183 26670-26805 Sentence denotes Alamandine receptor is a Mas-related G-protein coupled receptor, known as MrgD, which is expressed in cardiomyocytes and blood vessels.
T184 26806-26948 Sentence denotes MrgD knockout animals develop a severe cardiopathy and alamandine showed a cardioprotective effect in a model of sepsis (Santos et al., 2019).
T185 26949-27179 Sentence denotes Unlike ACE, ACE2 is not active on bradykinin, but it can degrade the active bradykinin metabolite des-Arg9 bradykinin (DABK), blocking the signaling pathway of the B1 bradykinin receptor (Vickers et al., 2002; Sodhi et al., 2018).
T186 27180-27287 Sentence denotes Other substrates of ACE2 include apelin-13/17, neurotensin, dynorphin A (1–13), and ghrelin (Turner, 2015).
T187 27288-27490 Sentence denotes Interestingly peptides of apelin family have been demonstrated to upregulate ACE2 expression in physiological condition and more actively during heart failure in in vivo experiments (Sato et al., 2013).
T188 27491-27755 Sentence denotes ACE2 in turn is able to regulate apelin bioavailability, establishing a negative feedback loop, and the crosstalk between RAAS, ACE2 and Apelin system might play a significant role in the pathophysiology of hypertension (Kalea and Batlle, 2010; Chen et al., 2015).
T189 27756-28110 Sentence denotes On the whole these findings suggest that ACE2 might exert antihypertensive and/or cardioprotective effects by different mechanisms, namely: (i) limiting the availability of ACE substrates, (ii) degrading Ang-II, (iii) activating the Ang1-7/MasR and/or Alamandine/MrgD pathways, (iv) interfering with other substrates, such as DABK and apelins (Figure 3).
T190 28112-28132 Sentence denotes ACE2 and Lung Injury
T191 28133-28267 Sentence denotes ACE2 is highly expressed in type I and II alveolar epithelial cells and in pulmonary small vessels (either endothelial cells or VSMC).
T192 28268-28574 Sentence denotes The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010).
T193 28575-28796 Sentence denotes ARDS is an overly aggressive form of ALI and it is the final mechanism of lung injury in many diseases, including sepsis, acid aspiration, pancreatitis, anthrax and virus infections (Spanish flu, H5N1 avian flu and SARS).
T194 28797-28942 Sentence denotes Imai et al. developed three ACE2 knockout mice models with severe ARDS induced by acid aspiration, endotoxin administration or peritoneal sepsis.
T195 28943-29164 Sentence denotes They showed that ARDS was accompanied by increased vessel permeability, lung oedema, and infiltration of inflammation cells, with consequent impairment of respiratory function (Imai et al., 2005, 2007; Kuba et al., 2006).
T196 29165-29309 Sentence denotes The phenotype was dramatically improved and rescued either administering ACE2 recombinant analogs or AT1Ra inhibitors (Imai et al., 2005, 2008).
T197 29310-29560 Sentence denotes ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012).
T198 29561-29759 Sentence denotes An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013).
T199 29760-29982 Sentence denotes The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015).
T200 29983-30061 Sentence denotes ACE2 might also modulate lung inflammation via the bradykinin-DABK/BKB1R axis.
T201 30062-30281 Sentence denotes In fact, decreased ACE2 function in mouse lungs caused increased activity of the DABK axis and triggered a proinflammatory cytokine storm (CXCL5, MIP2, KC, and TNF-α), leading to pulmonary collapse (Sodhi et al., 2018).
T202 30282-30345 Sentence denotes In human, ACE/ACE2 imbalance may be related to genetic factors.
T203 30346-30570 Sentence denotes In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002).
T204 30571-30791 Sentence denotes More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014).
T205 30793-30824 Sentence denotes Links Between ACE2 and COVID-19
T206 30825-31073 Sentence denotes A “second life” for ACE2 was discovered in 2003, when a novel respiratory infective disease, known as severe acute respiratory syndrome (SARS), appeared in China and spread all over Asia and Canada, with a lethality rate of 10% (Rota et al., 2003).
T207 31074-31223 Sentence denotes The responsible pathogen was identified in a positive strand RNA virus belonging to the coronavirus family and named SARS-CoV (Ksiazek et al., 2003).
T208 31224-31444 Sentence denotes The virus genome was sequenced and this allowed the identification of the spike glycoprotein (S), whose N-terminal portion, or S1-domain, was found to mediate the high affinity binding to host cells (Marra et al., 2003).
T209 31445-31732 Sentence denotes The group of Farzan et al. succeeded in identifying the cell receptor: they showed that SARS-CoV efficiently infected African Monkey kidney cell line Vero E6 and co-immunoprecipitated a glycoprotein responsible for virus binding and entry, which was identified as ACE2 (Li et al., 2003).
T210 31733-31839 Sentence denotes SARS-CoV caused the SARS epidemic in 2002–2003, with over 8,000 infections and a fatality rate around 10%.
T211 31840-32036 Sentence denotes In late 2019, another coronavirus emerged as a human pathogen in the city of Wuhan in China, producing symptoms such as fever, severe respiratory impairment, and pneumonia (Petersen et al., 2020).
T212 32037-32215 Sentence denotes This new coronavirus has been denominated SARS-CoV-2 for its genetic resemblance with SARS-CoV (∼80%), and its related disease has been named COVID-19 (COronaVIrus Disease 2019).
T213 32216-32376 Sentence denotes Owing to its high reproduction number R0 (2–3), SARS-CoV-2 has rapidly diffused in several countries and is currently posing a significant global health threat.
T214 32377-32450 Sentence denotes On March 11, 2020, the WHO has declared the COVID-19 outbreak a pandemic.
T215 32451-32645 Sentence denotes The early discovery that SARS-CoV-2 also engages ACE2 as entry door for cell infection has prompted an intense research effort to elucidate the biochemical determinants of CoV-ACE2 interactions.
T216 32647-32697 Sentence denotes Mechanism of Viral Entry Mediated by the S Protein
T217 32698-32823 Sentence denotes A coronavirus contains four structural proteins, namely spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins.
T218 32824-32950 Sentence denotes These proteins assemble around a lipid bilayer to provide the shell enclosing the viral genome (Figure 4A; Tang et al., 2020).
T219 32951-33142 Sentence denotes Homotrimers of S protrude from the viral surface, and are densely decorated by N-linked glycans, creating the “crown” (“Corona” in Latin) that christens this virus group (Walls et al., 2016).
T220 33143-33297 Sentence denotes S is a ∼180 kDa glycoprotein anchored in the viral membrane, which plays the most important roles in viral attachment, fusion and entry (Ou et al., 2020).
T221 33298-33448 Sentence denotes Sequence analysis has shown that SARS-CoV-2 S protein shares 76% of the primary sequence with the corresponding S of human SARS-CoV (Ou et al., 2020).
T222 33449-33579 Sentence denotes Accordingly, it has been early proposed that SARS-CoV-2 utilizes a similar cell entry mechanism as SARS-CoV, pivoted on S protein.
T223 33580-33650 Sentence denotes This hypothesis has been confirmed from an experimental point of view.
T224 33651-33863 Sentence denotes By using pseudotyped virus bearing SARS-CoV S or SARS-CoV-2 S, it was shown that a large panel of cell lines allows comparable entry of SARS-CoV or SARS-CoV-2 viruses (Hoffmann et al., 2020b; Walls et al., 2020).
T225 33864-33996 Sentence denotes FIGURE 4 (A) Structure of a Coronavirus. (B) Functional motifs in the sequence of the S “spike” protein of SARS-CoV and SARS-CoV-2.
T226 33997-34278 Sentence denotes The S protein consists of ∼1300 aminoacids and it is composed by a N-terminal “S1”subunit (∼700 aa) and a C-terminal “S2”subunit (∼600 aa); binding to the host receptor is mediated by S1, whereas S2 induces fusion of the viral envelope with cellular membranes (Walls et al., 2017).
T227 34279-34405 Sentence denotes S1 and S2 can be further subdivided in functional segments with different roles in viral entry (Figure 4B; Tang et al., 2020).
T228 34406-34506 Sentence denotes The S1 subunit contains two subdomains, the N-terminal domain (NTD) and the C-terminal domain (CTD).
T229 34507-34710 Sentence denotes In SARS-CoV (Li, 2015) and SARS-CoV-2 (Wang et al., 2020) CTD encloses the receptor-binding domain (RBD), and the RBD section that directly contacts the receptor is named as receptor-binding motif (RBM).
T230 34711-34864 Sentence denotes The N-region of S2 contains a fusion peptide (FP), two heptapeptide repeat domains (HR1, HR2), a transmembrane domain (TM), and cytoplasmic peptide (CP).
T231 34865-35032 Sentence denotes FP is a short segment composed of mostly hydrophobic residues, such as glycine (G) or alanine (A), which inserts in the host cell membrane to trigger the fusion event.
T232 35033-35216 Sentence denotes HR1 and HR2 are composed of a repetitive heptapeptide with HPPHCPC sequence, where H represents hydrophobic or bulky residues, P polar or hydrophilic residues, and C charged residues.
T233 35217-35315 Sentence denotes HR regions typically fold into α-helices with a hydrophobic interface that drives membrane fusion.
T234 35316-35513 Sentence denotes On the basis of the strong similarity between the S proteins of SARS-CoV and SARS-CoV-2, many researchers early set-out to demonstrate whether both viruses target the same host cell receptor, ACE2.
T235 35514-35672 Sentence denotes Zhou et al. (2020) highlighted that the virus was able to infect cell lines only when they expressed human, bat, civet, and pig (but not mouse) ACE2 receptor.
T236 35673-35864 Sentence denotes Hoffmann et al. (2020b), Ou et al. (2020), and Walls et al. (2020) elegantly outlined that the BHK cell line could be infected by pseudotyped SARS-CoV-2 or SARS-CoV only upon ACE2 expression.
T237 35865-36070 Sentence denotes Conversely, the expression of different human receptors used by other CoVs (hDPP4 and APN, used by MERS CoV and HCoV-229E, respectively) did not enable pseudovirus access to cells (Hoffmann et al., 2020b).
T238 36071-36165 Sentence denotes Taken together, these findings are solid evidence that SARS-CoV-2 engages ACE2 for cell entry.
T239 36166-36389 Sentence denotes Nonetheless, the two viruses were demonstrated by Xia to share also the membrane fusion mechanism, as strongly suggested by the impressive 89.9% sequence identity of S2 between SARS-CoV and SARS-CoV-2 (Xia et al., 2020a,b).
T240 36390-36615 Sentence denotes To date, the cell entry mechanism of SARS-CoV and SARS-CoV-2 has been understood in its general details and it is based on a concerted action of receptor binding and proteolysis of the S protein (Figure 5; Tang et al., 2020).
T241 36616-36807 Sentence denotes Ultrastructural studies showed a metastable “prefusion” V-shaped trimer composed by three S1 heads sitting on top of a trimeric S2 stalk anchored into the virus membrane (Walls et al., 2016).
T242 36808-37025 Sentence denotes The RBD constantly switches between a standing-up (“open”) position for receptor binding and a lying-down (“closed”) configuration, the latter allowing immune evasion (Figure 6; Song et al., 2018; Wrapp et al., 2020).
T243 37026-37144 Sentence denotes Yet only one of the three RBD in trimeric S can flip up at a time and interact with the receptor (Wrapp et al., 2020).
T244 37145-37307 Sentence denotes The second key feature of the fusion mechanism is “priming” by host proteases, which recognize and cleave a short peptide motif at the S1/S2 boundary (Figure 4B).
T245 37308-37671 Sentence denotes This cleavage does not disassemble S1 from S2 in pre-fusion conditions (Belouzard et al., 2009), but the binding interaction of RBD with its receptor, accompanied by a further cleavage in a second site in S2 (S2’site, upstream of FP, Figure 4B), triggers the possible dissociation of S1 and the irreversible refolding of S2 into a “post-fusion” state (Figure 4B).
T246 37672-37907 Sentence denotes In detail, HR1 undergoes a dramatic “jack-knife” conformational change, converting four helical stretches that run in an antiparallel fashion into a single long (∼130 aa) α-helix (Heald-Sargent and Gallagher, 2012; Walls et al., 2017).
T247 37908-38022 Sentence denotes At first, three of these helices assemble into a homotrimeric bundle and stick the FP into the host cell membrane.
T248 38023-38177 Sentence denotes Then, HR2 (one for each S2 chain) fold backward and bind to HR1, yielding the “six-helix bundle fusion core” (6-HB) of post-fusion S2 (Song et al., 2018).
T249 38178-38410 Sentence denotes This conformational foldback brings the FP (at N-terminus of HR1) and the TM (at the C terminus of HR2) close to each other, so that the viral and host cell membranes approach until their outer leaflets merge (hemifusion, Figure 5).
T250 38411-38621 Sentence denotes Eventually the inner leaflets merge (pore formation), enabling a connection between the interior of the virus and the host cell cytoplasm, that allows the delivery of viral genome (Figure 5; Tang et al., 2020).
T251 38622-38671 Sentence denotes FIGURE 5 Coronavirus viral fusion pathway model.
T252 38672-38735 Sentence denotes Initially, the S protein is in the pre-fusion native state (1).
T253 38736-39034 Sentence denotes Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2).
T254 39035-39214 Sentence denotes Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3).
T255 39215-39329 Sentence denotes The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state.
T256 39330-39500 Sentence denotes During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation).
T257 39501-39622 Sentence denotes Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle).
T258 39623-39655 Sentence denotes Adapted from Tang et al. (2020).
T259 39656-39732 Sentence denotes FIGURE 6 Trimeric S protein of SARS-CoV-2 in the ”Closed” and “Open” forms.
T260 39733-39821 Sentence denotes Note the single RBD protruding out of the V-shaped conformation of the protein assembly.
T261 39822-39870 Sentence denotes The structures have been drawn from PDB 6X2C (R.
T262 39871-39934 Sentence denotes Henderson, 10.1101/2020.05.18.10208) by Mol on the PDB website.
T263 39935-40104 Sentence denotes Although not directly related to ACE2, the role of S “priming” by host cell proteases deserves particular attention in the context of SARS-CoV-2 virus entry and tropism.
T264 40105-40317 Sentence denotes Possibly, the most notable feature of SARS-CoV-2 genome, as compared to SARS-CoV and some related bat coronaviruses, is a four basic aminoacid insert (PRRA) at the S1/S2 junction (Figure 4B; Jaimes et al., 2020).
T265 40318-40473 Sentence denotes This site is potentially cleavable by the protease furin, a proprotein convertase widely recognized to activate the fusion machinery of viral glycoprotein.
T266 40474-40706 Sentence denotes Indeed, many authors showed that pseudoviruses bearing SARS-CoV-2 S were already “primed” (i.e., cleaved) at the S1/S2 boundary by furin upon assembly in the cell, at odds with pseudoviruses bearing SARS-CoV S (Shang et al., 2020a).
T267 40707-41100 Sentence denotes SARS-COV-2 shows a large flexibility with regard to protease priming, which may independently occur by a) furin and furin-like proteases intracellularly, b) trypsin-like proteases such as TMPRSS2 that are present on the host cell membrane (particularly on airway epithelial cells), and 3) endosomal cathepsins activated by a drop in pH (e.g., cathepsin L) (Figure 7; Hoffmann et al., 2020a,b).
T268 41101-41252 Sentence denotes This flexibility could be the crucial factor that explain SARS-CoV-2 cell tropism and the peculiar features of COVID-19 symptoms (Jaimes et al., 2020).
T269 41253-41438 Sentence denotes Additionally, the kind of protease “priming” may determine whether the membrane fusion process occur directly at the plasma membrane or at endosomal level (Tang et al., 2020; Figure 7).
T270 41439-41524 Sentence denotes FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells.
T271 41525-41685 Sentence denotes The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell.
T272 41686-41911 Sentence denotes The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA.
T273 41912-42222 Sentence denotes Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles.
T274 42223-42333 Sentence denotes Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell.
T275 42335-42372 Sentence denotes SARS-CoV-2 RBD and Its Receptor, ACE2
T276 42373-42520 Sentence denotes Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV.
T277 42521-42597 Sentence denotes SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005).
T278 42598-42737 Sentence denotes Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020).
T279 42738-42868 Sentence denotes Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy.
T280 42869-43072 Sentence denotes Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor).
T281 43073-43202 Sentence denotes Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner.
T282 43203-43279 Sentence denotes The SARS-CoV-2 RBD sequence was further investigated by structural analysis.
T283 43280-43677 Sentence denotes X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020).
T284 43678-43945 Sentence denotes In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference.
T285 43946-44180 Sentence denotes FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue.
T286 44181-44253 Sentence denotes The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A).
T287 44254-44344 Sentence denotes The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website.
T288 44345-44422 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 44423-44509 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 44510-44670 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 44671-44785 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 44786-44934 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 44935-45126 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 45127-45344 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 45345-45522 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 45523-45766 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 45767-46093 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 46094-46211 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.
T299 46212-46305 Sentence denotes TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2.
T300 46306-46343 Sentence denotes Sequence KD (nM) Method References
T301 46344-46383 Sentence denotes SARS-2 S 14.7 SPR Wrapp et al., 2020
T302 46384-46421 Sentence denotes SARS-2 S 11.2 SPR Lei et al., 2020
T303 46422-46471 Sentence denotes SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020
T304 46472-46524 Sentence denotes SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020
T305 46525-46574 Sentence denotes SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020
T306 46575-46622 Sentence denotes SARS-2 S319–529 44.2 SPR Shang et al., 2020b
T307 46623-46689 Sentence denotes SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020
T308 46690-46755 Sentence denotes SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020
T309 46757-46790 Sentence denotes Structure of the ACE2-RBD Complex
T310 46791-47024 Sentence denotes Previous studies showed that the extracellular Peptidase Domain (PD) of ACE2, which adopts a claw-like morphology, is the interaction site of SARS-CoV RBD (Towler et al., 2004; Li, 2015; Kirchdoerfer et al., 2018; Song et al., 2018).
T311 47025-47199 Sentence denotes More specifically, ACE2 engages SARS-CoV RBD by establishing contacts with the 424–494 residue domain, which is referred to as Receptor Binding Motif (RBM) (Li et al., 2005).
T312 47200-47480 Sentence denotes In spite of the recent emergence of SARS-CoV-2, multiple authors have already highlighted the structure of ACE2/SARS-CoV-2 RBD complex by either X-ray (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020) or cryo-EM (Walls et al., 2020; Wrapp et al., 2020; Yan et al., 2020).
T313 47481-47591 Sentence denotes Pleasantly, all data converged to a consistent tridimensional arrangement of the receptor (Wang et al., 2020).
T314 47592-47709 Sentence denotes In the “closed” conformation of S protein, the RBD is buried at the interface between protomers (Walls et al., 2020).
T315 47710-47892 Sentence denotes Only in the “open” S conformation, RBD engages PD of ACE2 (Wrapp et al., 2020), and the complex may involve a dimeric ACE2 that accommodates two S protein trimers (Yan et al., 2020).
T316 47893-48082 Sentence denotes In keeping with their sequence similarity, strong structural homology was found between ACE2/SARS-CoV RBD and ACE2/SARS-CoV-2 RBD (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020).
T317 48083-48271 Sentence denotes SARS-CoV-2 RBM spans from residue 438–506 of S sequence and, likewise SARS-CoV RBM, it approaches the outer surface of ACE2 by a gently concave surface with a ridge on one side (Figure 8).
T318 48272-48437 Sentence denotes The concave surface is made up by the two short β5 and β6 sheets of the external RBD subdomain, whereas the ridge contains the β5/β6 loop (loop 1: residues 474–489).
T319 48438-48539 Sentence denotes A second smaller loop (loop 2: residues 498–505) is visible on the other side of the concave surface.
T320 48540-48805 Sentence denotes Inspection of the complex structure and molecular dynamics (MD) highlighted that the motifs 453–456 (in β5), 484–489 (in the loop 1), and 500–505 (in the loop 2) are at the basis of the largest differences between SARS-CoV-2 and SARS-CoV RBM interactions with ACE2.
T321 48806-49060 Sentence denotes SARS-CoV RBM ridge contains a Pro-Pro-Ala motif that is replaced by Gly-Val-Glu-Gly in SARS-CoV-2 (residues 482–485), yielding a more compact loop able to engage more interactions with proximal ACE2 residues (e.g., Ser19 and Gln24) (Shang et al., 2020b).
T322 49061-49269 Sentence denotes Additionally, Phe486 of SARS-CoV-2 RBM (which replaces Ile of SARS) inserts into a hydrophobic pocket on the receptor surface, establishing strong aromatic interactions with Tyr83 of ACE2 (Wang et al., 2020).
T323 49270-49365 Sentence denotes Asn501 in loop 2 further engages recognized hotspots on the ACE2 surface (Shang et al., 2020b).
T324 49366-49517 Sentence denotes Consistently, MD studies confirmed that loop 1 and 2 are much more rigid in RBM-ACE2 complex of SARS-CoV-2 with respect to SARS (Brielle et al., 2020).
T325 49518-49638 Sentence denotes These subtle structural differences probably account for the higher affinity of SARS-CoV-2 for ACE2 (Wang et al., 2020).
T326 49639-49848 Sentence denotes Interestingly, MD simulations suggest that the difference in affinity is largely due to the solvation energy, emphasizing the relevant role of hydrophobic patches in RBM/ACE2 binding surface (He et al., 2020).
T327 49849-50116 Sentence denotes It is worth noting that the RBD-receptor engagement is the crucial effector of viral-host interaction, which eventually determines viral host range, and in tandem with the host proteases is responsible for virus tropism and pathogenicity (Millet and Whittaker, 2015).
T328 50117-50351 Sentence denotes Structure-guided sequence analysis has suggested that several mammals, including pets such as cats and dogs, host ACE2 receptors that could bind effectively to SARS-CoV-2 S protein and propagate COVID-19 infection (Luan et al., 2020).
T329 50352-50434 Sentence denotes Yet, no correlation between genetic distance and the S/ACE2 interaction was found.
T330 50435-50646 Sentence denotes In this context, a third human CoV, hCoV-NL63, has been previously found to use ACE2 for cell entry (Hofmann et al., 2005), although its S1 sequence is rather dissimilar from SARS (23.4%) and SARS-CoV-2 (29.2%).
T331 50647-50819 Sentence denotes In spite of this, the structures of hCoV-NL63 (Wu et al., 2009) and SARS-CoV RBD (Li et al., 2005) were found to engage some sterically overlapping sites in ACE (Li, 2015).
T332 50820-50980 Sentence denotes This homology can be transitively extended to SARS-CoV-2, suggesting these three CoVs have evolved to recognize a “hotspot” region in ACE2 for receptor binding.
T333 50981-51174 Sentence denotes This might represent a critical feature for the appearance of novel CoV able to infect humans in the future, as it is known that at least three more bat CoVs bind ACE2 (Hoffmann et al., 2020b).
T334 51175-51398 Sentence denotes Indeed, bat RaTG13 CoV binds ACE2 and contains a similar four-residue motif in the ACE2 binding ridge of RBM, suggesting that SARS-CoV-2 could have evolved from RaTG13 or a yet-unknown related bat CoV (Shang et al., 2020b).
T335 51400-51441 Sentence denotes The Controversial Role of ACE2 Expression
T336 51442-51682 Sentence denotes Epidemiological data consistently show that the COVID-19 patients at highest risk of a poor prognosis are males older than 60 years with chronic underlying diseases, mostly hypertension, cardiovascular diseases and type-2 diabetes mellitus.
T337 51683-51865 Sentence denotes Clinical reports have been rapidly delivered from all over the world, and meta-analyses assessing the prevalence of comorbidities and their impact on prognosis are already available.
T338 51866-52113 Sentence denotes A meta-analysis pooling data from seven studies following a total number of 1,576 infected patients from hospitals in China found that the most prevalent comorbidities were hypertension (21.1%), diabetes (9.7%), and cardiovascular diseases (8.4%).
T339 52114-52322 Sentence denotes These increased the risk of developing a more serious disease (i.e., requiring intensive care treatment), with odds ratios ranging from 2.4 (hypertension) to 3.4 (cardiovascular disease) (Yang et al., 2020b).
T340 52323-52598 Sentence denotes These findings have been confirmed in the analysis performed by the Chinese Center for Disease Control and Prevention in a huge sample of 72314 COVID-19 cases (Epidemiology Working Group for Ncip Epidemic Response and Chinese Center for Disease Control and Prevention, 2020).
T341 52599-52752 Sentence denotes A study with 1591 Italian patients, similarly, reported a significant association between hypertension and mortality in Intensive Care Unit (63 vs. 40%).
T342 52753-52897 Sentence denotes This series reported an even higher prevalence of hypertension (49%), diabetes (17%), and cardiovascular disease (21%) (Grasselli et al., 2020).
T343 52898-53086 Sentence denotes Diabetes has been reported to predict the occurrence of ARDS (HR = 1.44), acute kidney injury (HR = 3.01), septic shock (HR = 1.95), and all-cause mortality (HR = 1.70) (Zhu et al., 2020).
T344 53087-53245 Sentence denotes Notably, poor glycemic control was significantly associated with worse clinical outcomes, namely multi-organ injuries and higher mortality (Zhu et al., 2020).
T345 53246-53327 Sentence denotes Obesity has also emerged as an important factor in determining COVID-19 severity.
T346 53328-53596 Sentence denotes Indeed, obesity was more frequent in patients admitted to critical care for SARS-CoV-2 as compared to the general population; moreover, the BMI was positively related to the need for invasive mechanical ventilation and mortality (Drucker, 2020; Simonnet et al., 2020).
T347 53597-53739 Sentence denotes The RAAS system is the target of widely used anti-hypertensive drugs, such as ACE-inhibitors (ACEI) and Ang-II type 1 receptor blockers (ARB).
T348 53740-53952 Sentence denotes Several experimental studies reported that, although not directly affecting ACE2 activity, these drugs are able to upregulate its expression (Ishiyama et al., 2004; Ferrario et al., 2005; Gallagher et al., 2008).
T349 53953-54185 Sentence denotes Increased expression of ACE2 has also been reported to facilitate SARS-CoV infection in several experimental models and postulated to act in the same way for SARS-CoV-2 (Li et al., 2003; Hofmann et al., 2004; Perrotta et al., 2020).
T350 54186-54356 Sentence denotes Hence, following the SARS-CoV-2 outbreak, it has been speculated that the use of ACEI and ARB could increase viral invasion and should therefore be temporarily suspended.
T351 54357-54825 Sentence denotes This topic has been abundantly debated in the last few months (March–May 2020), with contradictory views (Bavishi et al., 2020; Buckley et al., 2020; Danser et al., 2020; Fang et al., 2020; Huang Z. et al., 2020; Kreutz et al., 2020; Kuster et al., 2020; Mourad and Levy, 2020; Park et al., 2020; Rico-Mesa et al., 2020; Sommerstein et al., 2020; South et al., 2020; Tignanelli et al., 2020; Vaduganathan et al., 2020; Verdecchia et al., 2020b; Zhang P. et al., 2020).
T352 54826-55215 Sentence denotes As a consequence of this debate, several clinical societies have stated that suspension of ACEI and ARB is not justified on the basis of the present scientific evidence, although a recent BMJ editorial (Aronson and Ferner, 2020) suggested to consider stopping ACE inhibitors or angiotensin receptor blockers in patients with mild hypertension who are at high risk of coronavirus infection.
T353 55216-55441 Sentence denotes On the other hand, a different viewpoint is based on the intriguing observation that several conditions increasing the risk of viral infection and disease severity are all characterized by a certain degree of ACE2 deficiency.
T354 55442-55629 Sentence denotes As discussed above (section “Structure of ACE2”) ACE2 deficiency has been suggested to play a significant role in the pathophysiology of hypertension, cardiovascular disease and diabetes.
T355 55630-55827 Sentence denotes The role of ACE2 expression in the panel of comorbidities correlated to SARS-CoV-2 is a matter of intense still unsolved debate, as brilliantly revised by Shyh et al. (2020) in a very recent paper.
T356 55828-55967 Sentence denotes On the whole, there is still uncertainty about the relationship between ACE2 density on cell membrane and the fate of SARS-CoV-2 infection.
T357 55968-56309 Sentence denotes An interesting speculation which could reconcile the two position comes from the hypothesis that while ACE2 is for sure the entry door for the virus, once the infection has evolved, there is the subsequent downregulation of ACE2, responsible for the precipitating of respiratory distress, as showed also in animal models (Kuba et al., 2005).
T358 56310-56482 Sentence denotes It should be pointed out that the great clinical impact of this issue has encouraged discussions that are largely based on indirect speculations rather than objective data.
T359 56483-56776 Sentence denotes Data from appropriate clinical trials are still lacking, although a retrospective multicenter study on more than 1,000 patients with COVID-19 and hypertension treated with ACEI or ARB revealed that the use of these drugs was associated with lower mortality from all cause (Bosso et al., 2020).
T360 56777-57181 Sentence denotes A definite conclusion would require specific prospective clinical trials, which are still running: https://clinicaltrials.gov/ct2/show/NCT04312009 is a multi-centered double blind trial with the aim to test the role of ARB in patients with COVID-19 and https://clinicaltrials.gov/ct2/show/NCT04331574 is another trial evaluating the outcome of patients with COVID-19 in therapy with either ACEI and ARBS.
T361 57182-57737 Sentence denotes In the meanwhile, partial but important information might be obtained by circumscribed experimental and clinical investigations focused some on crucial issues, namely: fate of SARS-CoV-2 infection in human cells manipulated in order to modify ACE2 density; correlation of ACE2 density (in different cell types) and clinical course in human patients; potential role of additional proteins interacting with ACE2, such as the membrane transporter SIT1, which appears to be associated with COVID-19 prognosis and is also affected by anti-hypertensive therapy.
T362 57739-57787 Sentence denotes ACE2 and the Inflammatory Response to SARS-CoV-2
T363 57788-57954 Sentence denotes Differently from other flu-like viral infections, COVID19 showed a relatively high lethality, although the latter was quite different in different geographical areas.
T364 57955-58114 Sentence denotes The appearance of ARDS and acute severe lung injury was initially regarded as the main insult, and patients underwent the typical treatment developed for ARDS.
T365 58115-58430 Sentence denotes However, more recent evidence from autopsy series revealed that COVID-19 is a systemic disease, in which interstitial pneumonia is associated with extensive microvascular damage, which is not limited to the lungs and leads to fibrin deposition, neutrophils trapping in microvasculature, and arteriolar microthrombi.
T366 58431-58585 Sentence denotes Moreover, cardiovascular involvement has been observed, occasionally leading to myocardial injury and sudden death after weeks from the initial infection.
T367 58586-58757 Sentence denotes These findings are crucial to optimize the treatment of COVID-19 patients, hopefully improving the prognosis (Buja et al., 2020; Carsana et al., 2020; Magro et al., 2020).
T368 58758-58906 Sentence denotes Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection.
T369 58907-59045 Sentence denotes Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia.
T370 59046-59144 Sentence denotes In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required.
T371 59145-59270 Sentence denotes These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people.
T372 59271-59586 Sentence denotes Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020).
T373 59587-59705 Sentence denotes The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood.
T374 59706-59919 Sentence denotes As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes).
T375 59920-60048 Sentence denotes This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020).
T376 60049-60299 Sentence denotes The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016).
T377 60300-60546 Sentence denotes In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane.
T378 60547-60992 Sentence denotes One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9).
T379 60993-61100 Sentence denotes FIGURE 9 Possible role of ACE2 in the molecular mechanisms involved in the “cytokine storm” of SARS-CoV-2.
T380 61101-61322 Sentence denotes In the SARS-CoV-2 infection, pyroptosis has been demonstrated to be active in macrophages, being viroporin 3a a trigger for NLRP3 with subsequent production of proinflammatory cytokines, such as IL-1β (Chen et al., 2019).
T381 61323-61461 Sentence denotes In COVID-19 patients, the pyroptosis activation has been indirectly demonstrated by the high serum level of IL-1β (Huang C. et al., 2020).
T382 61462-61649 Sentence denotes Moreover, the severe leucopoenia and lymphopenia, commonly showed in COVID-19 pneumonia and associated with poor prognosis, are likely due to lymphocyte injury by pyroptosis (Yang, 2020).
T383 61650-61775 Sentence denotes Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system.
T384 61776-62072 Sentence denotes It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018).
T385 62073-62417 Sentence denotes The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release.
T386 62418-62657 Sentence denotes Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020).
T387 62658-62754 Sentence denotes The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm.
T388 62755-62951 Sentence denotes The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).
T389 62952-63040 Sentence denotes ACE2 shedding is an additional mechanism contributing to inflammation (Fu et al., 2020).
T390 63041-63294 Sentence denotes ACE2 shedding consists in proteolytic cleavage of the protein ectodomain and leads to the release of enzymatically active soluble ACE2 (sACE), whose action is not completely understood, but might enhance the pro-inflammatory response (Guy et al., 2005).
T391 63295-63510 Sentence denotes ADAM 17 and disintegrin are able to shed not only TNFα but also a variety of membrane-anchored enzymes, including ACE2 (Black et al., 1997; Palau et al., 2020), as demonstrated by Lambert in 2005 (Guy et al., 2005).
T392 63511-63827 Sentence denotes In their experiment, human embryonic kidney cells (HEK293) expressing human ACE2 (HEK-ACE2) were treated with phorbol myristate acetate stimulation and the production of a polypeptide of 105 kDa was demonstrated by western blot analysis, suggesting the occurrence of a proteolytic shedding in the ectodomain of ACE2.
T393 63828-64048 Sentence denotes Subsequently, they demonstrated that the cleavage was performed by ADAM17, incubating cells with a specific hydroxamic acid-based metalloproteinase inhibitor, namely TAPI-1 (TNFα protease inhibitor 1) (Guy et al., 2005).
T394 64049-64166 Sentence denotes ACE2 shedding seems to be inducible by specific stimuli produced either by a viral infection or by the immune system.
T395 64167-64280 Sentence denotes Jia et al. (2009) confirmed ACE2 shedding in differentiated primary airway epithelial cells and Calu-3-cell line.
T396 64281-64489 Sentence denotes Furthermore, they demonstrated that the incubation with IL-1β at the dosage of 100 ng/ml and TNF α 100 ng/ml induced ACE2 shedding and sACE release, with a maximum after 18 h of incubation (Jia et al., 2009).
T397 64490-64625 Sentence denotes These findings suggest that an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection.
T398 64626-64810 Sentence denotes Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).
T399 64811-64970 Sentence denotes Other conditions have been assumed to be involved in the susceptibility to SARS-CoV-2 and among them vitamin D deficiency was proposed as a credible candidate.
T400 64971-65132 Sentence denotes The interesting candidate could be identified as a modifiable risk factor (hypovitaminosis D) and a potential tool in COVID-19 prevention or ancillary treatment.
T401 65133-65789 Sentence denotes The rationale has been summarized by Grant et al. in a recent review on the evidence supporting a possible correlation between vitamin D and SARS-CoV-2 risk: (i) the seasonal flare of SARS-CoV-2 which coincides with the nadir of vitamin D levels, (ii) the association between hypovitaminosis D and pulmonary infections together with the demonstrated protective role in acute respiratory infections, in adults (iii) the anti-inflammatory role of vitamin D which could be of benefit against the so called “cytokine storm,” which seems to be a major player in SARS-CoV-2 morbidity and mortality (Martineau et al., 2017; Zhou et al., 2019; Grant et al., 2020).
T402 65791-65819 Sentence denotes ACE2 as a Therapeutic Target
T403 65820-65908 Sentence denotes As evidence builds up, ACE2 rapidly emerged as a specific target for COVID-19 treatment.
T404 65909-66213 Sentence denotes Since this enzyme was identified as the SARS-CoV-2 receptor (Zhou et al., 2020), several approaches to address ACE2 mediated infection have been described (Li Y. et al., 2020; Zhang H. et al., 2020), with the aim to prevent host cell entry and subsequent viral replication, as well as severe lung injury.
T405 66214-66267 Sentence denotes Potential therapeutic approaches include (Figure 10):
T406 66268-66379 Sentence denotes FIGURE 10 Schematic representation of the potential therapeutic approaches to address ACE2 mediated infection.
T407 66380-66584 Sentence denotes Exogenous administration of soluble recombinant human ACE 2 sequesters circulating viral particles, while specific ACE2 blockers bind the receptor, impeding the S-protein interaction with the host target.
T408 66585-66587 Sentence denotes 1.
T409 66589-66603 Sentence denotes ACE2 blockers;
T410 66604-66606 Sentence denotes 2.
T411 66608-66641 Sentence denotes Exogenous administration of ACE2.
T412 66643-66656 Sentence denotes ACE2 Blockers
T413 66657-66907 Sentence denotes Blockade of ACE2 receptor could be achieved through specific antibodies (Li et al., 2003), rationally designed small molecules (Dales et al., 2002; Huentelman et al., 2004; Gross et al., 2020; Pillaiyar et al., 2020) or peptides (Huang et al., 2003).
T414 66908-67096 Sentence denotes Although their efficacy needs to be confirmed, some of these agents are currently available on the market and have been show to effectively block SARS-CoV invasion (Li S.-R. et al., 2020).
T415 67097-67424 Sentence denotes For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004).
T416 67425-67623 Sentence denotes Therefore, although ACE2 catalytic site is distinct from the S-protein-binding domain, NAAE exerts dual inhibitory effects on ACE2 catalytic activity and SARS binding (Adedeji and Sarafianos, 2014).
T417 67624-67920 Sentence denotes However, since a protecting role for ACE2 receptor against virus-induced acute lung injury in infections with SARS coronavirus has not been excluded (Imai et al., 2005; Kuba et al., 2005; Li S.-R. et al., 2020), the choice of ACE2 inhibition as therapeutic approach should be carefully evaluated.
T418 67922-67954 Sentence denotes Exogenous Administration of ACE2
T419 67955-68363 Sentence denotes The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a).
T420 68364-68543 Sentence denotes A pilot clinical study is currently investigating the efficiency of a recombinant human angiotensin-converting enzyme 2 (rhACE2) in patients with COVID-19 (Zhang H. et al., 2020).
T421 68544-68748 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 68749-69104 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 69105-69311 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 69312-69473 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 69474-69680 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.
T426 69681-69910 Sentence denotes Additionally, the availability of ACE2 nanoparticles applied to nose filters, chewing gums, clothes, filters and gloves could be of help in sequestering the virus thus preventing its entry into the host (Aydemir and Ulusu, 2020).
T427 69911-70143 Sentence denotes Prevention virus transmission could represent a more convenient strategy than therapeutic interventions on viral infection, avoiding interference with ACE2 and disturbance of the finely regulated RAAS axis (Aydemir and Ulusu, 2020).
T428 70145-70168 Sentence denotes ACE2 and Other Diseases
T429 70169-70223 Sentence denotes ACE2 is a multiform protein (Feng et al., 2010, 2011).
T430 70224-70414 Sentence denotes As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013).
T431 70415-70527 Sentence denotes Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis.
T432 70528-70645 Sentence denotes Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012).
T433 70646-70743 Sentence denotes Moreover, ACE2 participates in the regulation of metabolism, particularly of glucose homeostasis.
T434 70744-70851 Sentence denotes In the pancreas, activation of the ACE2-Ang1-7-MasR pathway improves insulin secretion (Yuan et al., 2013).
T435 70852-71038 Sentence denotes Obesity and high-fat diets cause a reduction in ACE2 expression in the adipose tissue, which in turn results in increased blood pressure (Gupte et al., 2008, 2012; Carsana et al., 2020).
T436 71039-71184 Sentence denotes A role for ACE2 is emerging in Alzheimer disease, since it has been shown that ACE2 can hydrolyse Beta amyloid peptides (Zou et al., 2007, 2013).
T437 71185-71268 Sentence denotes There is also increasing evidence that the RAAS system may be implicated in cancer.
T438 71269-71469 Sentence denotes ACE2 was found to inhibit cancer cell growth, metastasis, and angiogenesis in breast (Yu et al., 2016; Zhang Q. et al., 2019), pancreatic (Zhou et al., 2011), and colon cancer (Bernardi et al., 2012).
T439 71470-71679 Sentence denotes Another study pointed out that hepatocellular carcinoma patients with higher levels of ACE2 had longer survival times, suggesting a positive link between ACE2 expression and better prognosis (Ye et al., 2015).
T440 71680-71846 Sentence denotes Studies on human xenografts in mice clearly indicated that ACE2 inhibited tumor growth by suppressing invasion and angiogenesis in Non-Small Cell Lung Cancer (NSCLC).
T441 71847-72120 Sentence denotes Remarkably, the same group demonstrated that overexpression of ACE2 promotes the expression of E-cadherin at expenses of mesenchymal markers such as vimentin, and thereby inhibits the epithelial-mesenchymal transition in NSCLC models (Feng et al., 2010; Qian et al., 2013).
T442 72121-72327 Sentence denotes The discovery that lung cancer patients that harbor COVID-19 display more severe symptoms (Liang et al., 2020) set out intensive research on the possible connection between malignancies and ACE2 expression.
T443 72328-72445 Sentence denotes A thorough bioinformatics analysis of the TCGA dataset on several kinds of cancer (Chai et al., 2020) has shown that:
T444 72446-72514 Sentence denotes (1) Mutation and amplification of ACE2 gene are frequent in cancer.
T445 72515-72620 Sentence denotes Yet, hot-spot mutation sites were never observed, as ACE2 mutations were distributed across all 18 exons.
T446 72621-72877 Sentence denotes (2) ACE2 transcription was upregulated in six tumors: colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and lung adenocarcinoma (LUAD).
T447 72878-72965 Sentence denotes Interestingly, ACE2 transcription was unchanged in lung squamous cell carcinoma (LUSC).
T448 72966-73110 Sentence denotes (3) ACE2 transcription was downregulated in three tumors: testicular germ cell (TGCT), thyroid carcinoma (THCA), and kidney chromophobe (KICH).
T449 73111-73266 Sentence denotes (4) Changes of ACE2 transcription were epigenetic in nature, as both mutation and copy variation of ACE2 did not correlate with its up- or downregulation.
T450 73267-73371 Sentence denotes (5) In most cases, changes of ACE2 transcription strongly correlated with methylation in ACE2 promoter.
T451 73372-73502 Sentence denotes More specifically, decreased methylation levels correlated with upregulation, whereas increased methylation led to downregulation.
T452 73503-73590 Sentence denotes (6) No prognostic role of ACE2 expression on patient’s survival could be demonstrated.
T453 73591-73711 Sentence denotes These data confirm the remarkable role of methylation in determining the ACE2 expression, as described in paragraph 2.2.
T454 73712-74057 Sentence denotes Interestingly, a second bioinformatics study on Oncomine and TCGA databases gave slightly different results in terms of tumor-associated ACE2 expression changes, but confirmed the role of promoter hypomethylation in KIRP and uterine corpus endometrial carcinoma (UCEC) where ACE2 transcription was significantly upregulated (Yang et al., 2020a).
T455 74059-74069 Sentence denotes Conclusion
T456 74070-74193 Sentence denotes From the structural point of view ACE2 is closely related to ACE, and its discovery was a by-product of ACE investigations.
T457 74194-74308 Sentence denotes However, this macromolecule has soon showed peculiar functional properties and has attracted increasing attention.
T458 74309-74560 Sentence denotes The expression of ACE2 in the heart, kidney and vascular system pointed to a role in the regulation of blood pressure and cardiovascular homeostasis, possibly as a counterbalance to ACE activation, but this hypothesis now appears to be too simplistic.
T459 74561-74759 Sentence denotes Additional functions of ACE2 are strongly suggested by its capability to modulate cytokine metabolism and the inflammatory reaction, as well as by its remarkable expression in the respiratory tract.
T460 74760-74970 Sentence denotes The recent COVID-19 pandemic has put ACE2 in the spotlight, since it has been identified as the initial target of the SARS-Cov and SARS-Cov2 viruses, representing the receptor responsible for cellular adhesion.
T461 74971-75204 Sentence denotes Recent investigations have clarified the molecular details of the interaction of ACE2 with the spike glycoprotein present in this class of coronaviruses, and have partly unraveled the mechanism of protein cleavage and cellular entry.
T462 75205-75503 Sentence denotes ACE2 density on cell surface and ACE2-modulated inflammatory reactions have been suggested to be important determinants of COVID-19 susceptibility and clinical course, while drugs interfering with ACE2 expression, availability and processing are under investigation as potential therapeutic agents.
T463 75504-75710 Sentence denotes However, several crucial issues concerning the link between ACE2 and COVID-19 pathophysiology are still unclear, pointing to the need for focused experimental investigations and prospective clinical trials.
T464 75712-75732 Sentence denotes Author Contributions
T465 75733-75835 Sentence denotes FS, GR, SS, LB, BS, and RB wrote the first draft of the manuscript and prepared the table and figures.
T466 75836-75871 Sentence denotes RZ revised and integrated the text.
T467 75872-75931 Sentence denotes All authors decided upon the general outline of the review.
T468 75933-75953 Sentence denotes Conflict of Interest
T469 75954-76126 Sentence denotes The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.