PMC:7556165 / 22358-23203 JSONTXT

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T87","span":{"begin":284,"end":291},"obj":"Chemical"}],"attributes":[{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T67","span":{"begin":682,"end":689},"obj":"Species"}],"attributes":[{"id":"A67","pred":"ncbi_taxonomy_id","subj":"T67","obj":"NCBItxid:9989"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T144","span":{"begin":0,"end":278},"obj":"Sentence"},{"id":"T145","span":{"begin":279,"end":468},"obj":"Sentence"},{"id":"T146","span":{"begin":469,"end":678},"obj":"Sentence"},{"id":"T147","span":{"begin":679,"end":845},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T72","span":{"begin":51,"end":56},"obj":"Body_part"},{"id":"T73","span":{"begin":95,"end":101},"obj":"Body_part"},{"id":"T74","span":{"begin":102,"end":113},"obj":"Body_part"},{"id":"T75","span":{"begin":132,"end":141},"obj":"Body_part"},{"id":"T76","span":{"begin":371,"end":386},"obj":"Body_part"},{"id":"T77","span":{"begin":402,"end":410},"obj":"Body_part"},{"id":"T78","span":{"begin":412,"end":419},"obj":"Body_part"},{"id":"T79","span":{"begin":425,"end":430},"obj":"Body_part"},{"id":"T80","span":{"begin":462,"end":467},"obj":"Body_part"},{"id":"T81","span":{"begin":475,"end":481},"obj":"Body_part"},{"id":"T82","span":{"begin":489,"end":504},"obj":"Body_part"},{"id":"T83","span":{"begin":518,"end":525},"obj":"Body_part"},{"id":"T84","span":{"begin":530,"end":535},"obj":"Body_part"},{"id":"T85","span":{"begin":756,"end":762},"obj":"Body_part"},{"id":"T86","span":{"begin":784,"end":804},"obj":"Body_part"}],"attributes":[{"id":"A78","pred":"uberon_id","subj":"T78","obj":"http://purl.obolibrary.org/obo/UBERON_0002115"},{"id":"A80","pred":"uberon_id","subj":"T80","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A74","pred":"uberon_id","subj":"T74","obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"id":"A77","pred":"uberon_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/UBERON_0002114"},{"id":"A82","pred":"uberon_id","subj":"T82","obj":"http://purl.obolibrary.org/obo/UBERON_0001555"},{"id":"A76","pred":"uberon_id","subj":"T76","obj":"http://purl.obolibrary.org/obo/UBERON_0002108"},{"id":"A85","pred":"uberon_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A81","pred":"uberon_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"id":"A86","pred":"uberon_id","subj":"T86","obj":"http://purl.obolibrary.org/obo/UBERON_0000006"},{"id":"A79","pred":"uberon_id","subj":"T79","obj":"http://purl.obolibrary.org/obo/UBERON_0002116"},{"id":"A73","pred":"uberon_id","subj":"T73","obj":"http://purl.obolibrary.org/obo/UBERON_0000055"},{"id":"A83","pred":"uberon_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/UBERON_0000945"},{"id":"A72","pred":"uberon_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"A84","pred":"uberon_id","subj":"T84","obj":"http://purl.obolibrary.org/obo/UBERON_0001155"},{"id":"A75","pred":"uberon_id","subj":"T75","obj":"http://purl.obolibrary.org/obo/UBERON_0002394"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"620","span":{"begin":14,"end":18},"obj":"Gene"},{"id":"621","span":{"begin":279,"end":283},"obj":"Gene"},{"id":"622","span":{"begin":691,"end":695},"obj":"Gene"},{"id":"623","span":{"begin":462,"end":467},"obj":"Disease"},{"id":"624","span":{"begin":530,"end":535},"obj":"Disease"},{"id":"625","span":{"begin":735,"end":755},"obj":"Disease"}],"attributes":[{"id":"A621","pred":"pubann:denotes","subj":"621","obj":"Gene:59272"},{"id":"A624","pred":"pubann:denotes","subj":"624","obj":"MESH:D003110"},{"id":"A625","pred":"pubann:denotes","subj":"625","obj":"MESH:D010195"},{"id":"A622","pred":"pubann:denotes","subj":"622","obj":"Gene:59272"},{"id":"A620","pred":"pubann:denotes","subj":"620","obj":"Gene:59272"},{"id":"A623","pred":"pubann:denotes","subj":"623","obj":"MESH:D003110"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1979","span":{"begin":14,"end":18},"obj":"Protein"},{"id":"T1980","span":{"begin":279,"end":283},"obj":"Protein"},{"id":"T1981","span":{"begin":691,"end":695},"obj":"Protein"}],"attributes":[{"id":"A1979","pred":"uniprot_id","subj":"T1979","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1980","pred":"uniprot_id","subj":"T1980","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1981","pred":"uniprot_id","subj":"T1981","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T55","span":{"begin":153,"end":158},"obj":"http://purl.obolibrary.org/obo/CL_0000000"},{"id":"T56","span":{"begin":475,"end":481},"obj":"http://purl.obolibrary.org/obo/OBI_0100026"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T167","span":{"begin":51,"end":56},"obj":"Body_part"},{"id":"T168","span":{"begin":102,"end":113},"obj":"Body_part"},{"id":"T169","span":{"begin":132,"end":141},"obj":"Body_part"},{"id":"T170","span":{"begin":142,"end":158},"obj":"Body_part"},{"id":"T171","span":{"begin":153,"end":158},"obj":"Body_part"},{"id":"T172","span":{"begin":203,"end":214},"obj":"Body_part"},{"id":"T173","span":{"begin":284,"end":291},"obj":"Body_part"},{"id":"T174","span":{"begin":323,"end":335},"obj":"Body_part"},{"id":"T175","span":{"begin":339,"end":350},"obj":"Body_part"},{"id":"T176","span":{"begin":371,"end":386},"obj":"Body_part"},{"id":"T177","span":{"begin":402,"end":410},"obj":"Body_part"},{"id":"T178","span":{"begin":412,"end":419},"obj":"Body_part"},{"id":"T179","span":{"begin":425,"end":430},"obj":"Body_part"},{"id":"T180","span":{"begin":443,"end":454},"obj":"Body_part"},{"id":"T181","span":{"begin":462,"end":467},"obj":"Body_part"},{"id":"T182","span":{"begin":489,"end":504},"obj":"Body_part"},{"id":"T183","span":{"begin":518,"end":525},"obj":"Body_part"},{"id":"T184","span":{"begin":530,"end":535},"obj":"Body_part"},{"id":"T185","span":{"begin":550,"end":562},"obj":"Body_part"},{"id":"T186","span":{"begin":620,"end":627},"obj":"Body_part"},{"id":"T187","span":{"begin":756,"end":762},"obj":"Body_part"},{"id":"T188","span":{"begin":784,"end":804},"obj":"Body_part"}],"attributes":[{"id":"A188","pred":"fma_id","subj":"T188","obj":"http://purl.org/sig/ont/fma/fma76489"},{"id":"A179","pred":"fma_id","subj":"T179","obj":"http://purl.org/sig/ont/fma/fma7208"},{"id":"A178","pred":"fma_id","subj":"T178","obj":"http://purl.org/sig/ont/fma/fma7207"},{"id":"A169","pred":"fma_id","subj":"T169","obj":"http://purl.org/sig/ont/fma/fma9706"},{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A182","pred":"fma_id","subj":"T182","obj":"http://purl.org/sig/ont/fma/fma317863"},{"id":"A185","pred":"fma_id","subj":"T185","obj":"http://purl.org/sig/ont/fma/fma70977"},{"id":"A186","pred":"fma_id","subj":"T186","obj":"http://purl.org/sig/ont/fma/fma85355"},{"id":"A176","pred":"fma_id","subj":"T176","obj":"http://purl.org/sig/ont/fma/fma7200"},{"id":"A168","pred":"fma_id","subj":"T168","obj":"http://purl.org/sig/ont/fma/fma63916"},{"id":"A171","pred":"fma_id","subj":"T171","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A183","pred":"fma_id","subj":"T183","obj":"http://purl.org/sig/ont/fma/fma7148"},{"id":"A184","pred":"fma_id","subj":"T184","obj":"http://purl.org/sig/ont/fma/fma14543"},{"id":"A170","pred":"fma_id","subj":"T170","obj":"http://purl.org/sig/ont/fma/fma66768"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma70977"},{"id":"A177","pred":"fma_id","subj":"T177","obj":"http://purl.org/sig/ont/fma/fma7206"},{"id":"A167","pred":"fma_id","subj":"T167","obj":"http://purl.org/sig/ont/fma/fma7197"},{"id":"A181","pred":"fma_id","subj":"T181","obj":"http://purl.org/sig/ont/fma/fma14543"},{"id":"A187","pred":"fma_id","subj":"T187","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A175","pred":"fma_id","subj":"T175","obj":"http://purl.org/sig/ont/fma/fma62122"},{"id":"A180","pred":"fma_id","subj":"T180","obj":"http://purl.org/sig/ont/fma/fma62122"},{"id":"A172","pred":"fma_id","subj":"T172","obj":"http://purl.org/sig/ont/fma/fma14515"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T67","span":{"begin":51,"end":56},"obj":"http://purl.obolibrary.org/obo/MAT_0000097"},{"id":"T68","span":{"begin":95,"end":101},"obj":"http://purl.obolibrary.org/obo/MAT_0000393"},{"id":"T69","span":{"begin":371,"end":386},"obj":"http://purl.obolibrary.org/obo/MAT_0000047"},{"id":"T70","span":{"begin":377,"end":386},"obj":"http://purl.obolibrary.org/obo/MAT_0000043"},{"id":"T71","span":{"begin":402,"end":410},"obj":"http://purl.obolibrary.org/obo/MAT_0000044"},{"id":"T72","span":{"begin":412,"end":419},"obj":"http://purl.obolibrary.org/obo/MAT_0000045"},{"id":"T73","span":{"begin":425,"end":430},"obj":"http://purl.obolibrary.org/obo/MAT_0000282"},{"id":"T74","span":{"begin":462,"end":467},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T75","span":{"begin":518,"end":525},"obj":"http://purl.obolibrary.org/obo/MAT_0000051"},{"id":"T76","span":{"begin":530,"end":535},"obj":"http://purl.obolibrary.org/obo/MAT_0000526"},{"id":"T77","span":{"begin":784,"end":804},"obj":"http://purl.obolibrary.org/obo/MAT_0000076"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"620","span":{"begin":14,"end":18},"obj":"Gene"},{"id":"621","span":{"begin":279,"end":283},"obj":"Gene"},{"id":"622","span":{"begin":691,"end":695},"obj":"Gene"},{"id":"623","span":{"begin":462,"end":467},"obj":"Disease"},{"id":"624","span":{"begin":530,"end":535},"obj":"Disease"},{"id":"625","span":{"begin":735,"end":755},"obj":"Disease"}],"attributes":[{"id":"A620","pred":"tao:has_database_id","subj":"620","obj":"Gene:59272"},{"id":"A621","pred":"tao:has_database_id","subj":"621","obj":"Gene:59272"},{"id":"A622","pred":"tao:has_database_id","subj":"622","obj":"Gene:59272"},{"id":"A623","pred":"tao:has_database_id","subj":"623","obj":"MESH:D003110"},{"id":"A624","pred":"tao:has_database_id","subj":"624","obj":"MESH:D003110"},{"id":"A625","pred":"tao:has_database_id","subj":"625","obj":"MESH:D010195"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T144","span":{"begin":0,"end":278},"obj":"Sentence"},{"id":"T145","span":{"begin":279,"end":468},"obj":"Sentence"},{"id":"T146","span":{"begin":469,"end":678},"obj":"Sentence"},{"id":"T147","span":{"begin":679,"end":845},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020). ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon. Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004). In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010)."}