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PMC:7556165 / 18356-25678 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T60 3048-3068 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunohistochemistry http://purl.bioontology.org/ontology/MEDDRA/10059656

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T80 58-65 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 376-383 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T82 2107-2114 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T83 3147-3150 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T84 3564-3571 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T85 3674-3677 Chemical denotes cat http://purl.obolibrary.org/obo/CHEBI_149681|http://purl.obolibrary.org/obo/CHEBI_32402
T87 4286-4293 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 5593-5596 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T89 6010-6014 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T90 6217-6224 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T47 1287-1292 Species denotes human NCBItxid:9606
T48 1598-1604 Species denotes rodent NCBItxid:9989
T49 1897-1902 Species denotes human NCBItxid:9606
T50 2169-2174 Species denotes human NCBItxid:9606
T51 2742-2750 Species denotes primates NCBItxid:9443
T52 2863-2870 Species denotes trachea NCBItxid:988164
T53 2938-2943 Species denotes human NCBItxid:9606
T54 3270-3280 Species denotes SARS-CoV-2 NCBItxid:2697049
T55 3270-3274 Species denotes SARS NCBItxid:694009
T56 3354-3362 Species denotes COVID-19 NCBItxid:2697049
T57 3662-3667 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T59 3669-3672 Species denotes rat NCBItxid:10116|NCBItxid:10114
T61 3674-3677 Species denotes cat NCBItxid:9685
T62 3679-3685 Species denotes ferret NCBItxid:9669
T63 3687-3693 Species denotes monkey NCBItxid:9527|NCBItxid:9479
T65 3698-3703 Species denotes human NCBItxid:9606
T66 3847-3854 Species denotes rodents NCBItxid:9989
T67 4684-4691 Species denotes rodents NCBItxid:9989
T68 4887-4892 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T70 5496-5507 Species denotes hippocampus NCBItxid:72046
T71 6051-6056 Species denotes human NCBItxid:9606
T72 6239-6244 Species denotes human NCBItxid:9606
T73 6457-6463 Species denotes rodent NCBItxid:9989
T74 6601-6606 Species denotes human NCBItxid:9606
T75 6676-6681 Species denotes human NCBItxid:9606
T76 7092-7097 Species denotes human NCBItxid:9606

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T124 0-27 Sentence denotes Tissue Distribution of ACE2
T125 28-168 Sentence denotes Detectable quantities of ACE2 protein have been found almost ubiquitously in tissues across mammalian species, using immunostaining methods.
T126 169-386 Sentence denotes ACE2 is predominantly located in the cardiovascular system and kidney, where it probably plays a role in the maintenance of hydro electrolyte homeostasis (section “Mechanism of Viral Entry Mediated by the S Protein”).
T127 387-605 Sentence denotes In fact, ACE2 is pervasively expressed throughout the vasculature, at the level of the arteries and veins, mainly in smooth muscle cells of the media and in the endothelium (Hamming et al., 2004; Burrell et al., 2005).
T128 606-696 Sentence denotes Such signal from vessels also delivers part of the expression detected in specific organs.
T129 697-1035 Sentence denotes Indeed, ACE2 is evident in: coronary vessels and myocardial capillaries (Wiener et al., 2007; Garabelli et al., 2008); lung microvascular endothelial cells (Wiener et al., 2007; Chen et al., 2013); kidney interlobular arteries (Lely et al., 2004); endothelial and smooth muscle cells in the brain (Hamming et al., 2004; Kar et al., 2010).
T130 1036-1213 Sentence denotes Notably, the mesangium and glomerular endothelium in the kidney, and the endothelial lining of the sinusoids in the liver are allegedly negative for ACE2 (Hamming et al., 2004).
T131 1214-1401 Sentence denotes On the contrary, ACE2 is virtually absent from the lymphatic system, and human hemato-lymphoid organs (i.e., spleen, lymph nodes, and bone marrow) (Hamming et al., 2004; Li et al., 2007).
T132 1402-1549 Sentence denotes In blood cells, it has been observed in platelets and macrophages, but not in B and T lymphocytes (Hamming et al., 2004; Fraga-Silva et al., 2011).
T133 1550-1893 Sentence denotes Expression of ACE2 was originally identified in rodent heart (Donoghue et al., 2000a), where it was observed to occur in both atrium an ventricle (Gembardt et al., 2005), and, cellularly, in cardiomyocytes and in specialized cells of the sinoatrial node (Burrell et al., 2005; Garabelli et al., 2008; Ferreira et al., 2011; Wang et al., 2017).
T134 1894-2086 Sentence denotes In human heart, ACE2 has been found in the stromal area in spongiosa layer in aortic valves (Peltonen et al., 2011), where it is expressed in myofibroblasts and fibroblasts (Guy et al., 2008).
T135 2087-2374 Sentence denotes High levels of ACE2 protein expression have been detected in mammalian, including human, kidney (Gembardt et al., 2005; Koka et al., 2008; Reich et al., 2008; Giani et al., 2012; Mitani et al., 2014; Grobe et al., 2015; Shi et al., 2015; Larouche-Lebel et al., 2019; Alawi et al., 2020).
T136 2375-2713 Sentence denotes Strong signals were reported in the brush border of the proximal tubular cells, whereas weak to moderate signals could be found in the glomeruli, Henle’s loop, distal tubules, and collecting duct (Hamming et al., 2004; Lely et al., 2004; Kamilic et al., 2010; Giani et al., 2012; Bae et al., 2015; Cao et al., 2017; Errarte et al., 2017).
T137 2714-2908 Sentence denotes In the respiratory tract of primates, positive labeling for ACE2 has been reported at multiple sites, from the nasal and oral mucosa, to the larynx, trachea, bronchi and lung (Liu et al., 2011).
T138 2909-3194 Sentence denotes Whether ACE2 is expressed in human nasal and oral epithelium remains unclear, as contradictory results have been reported by studies using immunohistochemistry (Hamming et al., 2004; Bertram et al., 2012), in face of positive single-cell RNA sequencing findings (Sungnak et al., 2020).
T139 3195-3365 Sentence denotes This point is of great interest to understand the role of those tissues in SARS-CoV-2 initial infection, spread and clearance (section “Links Between ACE2 and COVID-19”).
T140 3366-3523 Sentence denotes In the upper respiratory tract ACE2 is expressed in the epithelial lining and lamina propria, in some muscle cells and in the salivary gland duct epithelium.
T141 3524-3818 Sentence denotes In the lung, an intense signal for ACE2 protein has been consistently observed in type I and II pneumocytes in several species, including mouse, rat, cat, ferret, monkey and human (Wiener et al., 2007; van den Brand et al., 2008; Liu et al., 2011; Wong et al., 2012; Chen et al., 2013; Zhang B.
T142 3819-3836 Sentence denotes N. et al., 2019).
T143 3837-4001 Sentence denotes Data from rodents suggest an age- and gender-dependent pattern of expression, with a more rapid decline with age in males as compared to females (Xie et al., 2006).
T144 4002-4280 Sentence denotes Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020).
T145 4281-4470 Sentence denotes ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon.
T146 4471-4680 Sentence denotes Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004).
T147 4681-4847 Sentence denotes In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010).
T148 4848-4938 Sentence denotes ACE2 distribution is widespread in the mouse brain, from the telencephalon to the medulla.
T149 4939-5345 Sentence denotes As expected, ACE2 is found in brain areas involved in the regulation of cardiovascular function and fluid balance, such as the vascular organ of lamina terminalis, subfornical organ, magnocellular neurons in the hypothalamic paraventricular nucleus, area postrema, nucleus of the solitary tract, dorsal motor nucleus of the vagus, nucleus ambiguous, and rostral ventrolateral medulla (Doobay et al., 2007).
T150 5346-5629 Sentence denotes However, significant expression had also been reported in brain areas not engaged in the classical functions of the RAAS, namely the piriform cortex, hippocampus, caudate putamen, hypoglossal nucleus and primary motor cortex (Doobay et al., 2007; Lin et al., 2008; Liu et al., 2014).
T151 5630-5767 Sentence denotes ACE2 immunostaining was identified in neurons as well as astrocytes (Gallagher et al., 2006; Doobay et al., 2007; Yamazato et al., 2007).
T152 5768-5938 Sentence denotes Furthermore, ACE2 has been documented in the retina, predominantly in the inner nuclear layer but also in photoreceptors (Tikellis et al., 2004; Senanayake et al., 2007).
T153 5939-6047 Sentence denotes With regard to the endocrine system, ACE2 expression was found in both male and female reproductive systems.
T154 6048-6185 Sentence denotes In human testis, ACE2 was localized to the Leydig and Sertoli cells, and might be involved in testicular function (Douglas et al., 2004).
T155 6186-6453 Sentence denotes At present, no data about ACE2 protein expression is human ovaries is available, although evidence of expression in stroma, theca, and granulosa cells has been reported in other species (Tonellotto dos Santos et al., 2012; Barreta et al., 2015; Pereira et al., 2015).
T156 6454-6567 Sentence denotes In rodent bone, ACE2 is expressed in osteoblasts and osteoclasts, as well as in epithelial cells and fibroblasts.
T157 6568-6672 Sentence denotes However, a similar expression in human samples still awaits clarification (Queiroz-Junior et al., 2019).
T158 6673-6798 Sentence denotes In human skin, ACE2 was present in the basal cell layer of the epidermis extending to the basal cell layer of hair follicles.
T159 6799-6880 Sentence denotes Smooth muscle cells surrounding the sebaceous glands were also positive for ACE2.
T160 6881-6945 Sentence denotes Weak cytoplasmic staining was observed in sebaceous gland cells.
T161 6946-7030 Sentence denotes A strong granular staining pattern for ACE2 was seen in cells of the eccrine glands.
T162 7031-7211 Sentence denotes Positive staining for ACE2 was also noted in the membrane of human fat cells in various organs, including the epicardial adipose tissue (Hamming et al., 2004; Patel et al., 2016a).
T163 7212-7322 Sentence denotes Globally, ACE2 is chiefly bound to cell membranes, while negligible levels can be detected in the circulation.

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T29 0-6 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T30 206-227 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T31 232-238 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T32 441-452 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T33 548-559 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T34 623-630 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T35 689-695 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T36 725-741 Body_part denotes coronary vessels http://purl.obolibrary.org/obo/UBERON_0005985
T37 816-820 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T38 895-901 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T39 902-923 Body_part denotes interlobular arteries http://purl.obolibrary.org/obo/UBERON_0004723
T40 988-993 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T41 1049-1058 Body_part denotes mesangium http://purl.obolibrary.org/obo/UBERON_0002319
T42 1063-1085 Body_part denotes glomerular endothelium http://purl.obolibrary.org/obo/UBERON_0004189
T43 1093-1099 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T44 1135-1144 Body_part denotes sinusoids http://purl.obolibrary.org/obo/UBERON_0003909
T45 1152-1157 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T46 1309-1315 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T47 1323-1329 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T48 1331-1342 Body_part denotes lymph nodes http://purl.obolibrary.org/obo/UBERON_0000029
T49 1348-1359 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T50 1405-1410 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T51 1605-1610 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T52 1788-1803 Body_part denotes sinoatrial node http://purl.obolibrary.org/obo/UBERON_0002351
T53 1903-1908 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T54 1972-1985 Body_part denotes aortic valves http://purl.obolibrary.org/obo/UBERON_0002137
T55 2176-2182 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T56 2535-2549 Body_part denotes distal tubules http://purl.obolibrary.org/obo/UBERON_0004135
T57 2566-2570 Body_part denotes duct http://purl.obolibrary.org/obo/UBERON_0000058
T58 2721-2738 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T59 2840-2846 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T60 2855-2861 Body_part denotes larynx http://purl.obolibrary.org/obo/UBERON_0001737
T61 2863-2870 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T62 2872-2879 Body_part denotes bronchi http://purl.obolibrary.org/obo/UBERON_0002185
T63 2884-2888 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T64 2954-2969 Body_part denotes oral epithelium http://purl.obolibrary.org/obo/UBERON_0002424
T65 3118-3122 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T66 3373-3396 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T67 3444-3458 Body_part denotes lamina propria http://purl.obolibrary.org/obo/UBERON_0000030
T68 3501-3506 Body_part denotes gland http://purl.obolibrary.org/obo/UBERON_0002530
T69 3507-3511 Body_part denotes duct http://purl.obolibrary.org/obo/UBERON_0000058
T70 3512-3522 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T71 3531-3535 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T72 4053-4058 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T73 4097-4103 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T74 4104-4115 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T75 4134-4143 Body_part denotes bile duct http://purl.obolibrary.org/obo/UBERON_0002394
T76 4373-4388 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T77 4404-4412 Body_part denotes duodenum http://purl.obolibrary.org/obo/UBERON_0002114
T78 4414-4421 Body_part denotes jejunum http://purl.obolibrary.org/obo/UBERON_0002115
T79 4427-4432 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T80 4464-4469 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T81 4477-4483 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T82 4491-4506 Body_part denotes digestive tract http://purl.obolibrary.org/obo/UBERON_0001555
T83 4520-4527 Body_part denotes stomach http://purl.obolibrary.org/obo/UBERON_0000945
T84 4532-4537 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T85 4758-4764 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T86 4786-4806 Body_part denotes islets of Langerhans http://purl.obolibrary.org/obo/UBERON_0000006
T87 4893-4898 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T88 4909-4922 Body_part denotes telencephalon http://purl.obolibrary.org/obo/UBERON_0001893
T89 4969-4974 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T90 5075-5080 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T91 5084-5090 Body_part denotes lamina http://purl.obolibrary.org/obo/UBERON_0000957
T92 5103-5120 Body_part denotes subfornical organ http://purl.obolibrary.org/obo/UBERON_0002219
T93 5189-5202 Body_part denotes area postrema http://purl.obolibrary.org/obo/UBERON_0002162
T94 5204-5233 Body_part denotes nucleus of the solitary tract http://purl.obolibrary.org/obo/UBERON_0009050
T95 5293-5322 Body_part denotes rostral ventrolateral medulla http://purl.obolibrary.org/obo/UBERON_0005807
T96 5404-5409 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T97 5479-5494 Body_part denotes piriform cortex http://purl.obolibrary.org/obo/UBERON_0004725
T98 5509-5524 Body_part denotes caudate putamen http://purl.obolibrary.org/obo/UBERON_0005383
T99 5526-5545 Body_part denotes hypoglossal nucleus http://purl.obolibrary.org/obo/UBERON_0002871
T100 5550-5570 Body_part denotes primary motor cortex http://purl.obolibrary.org/obo/UBERON_0001384
T101 5813-5819 Body_part denotes retina http://purl.obolibrary.org/obo/UBERON_0000966
T102 5958-5974 Body_part denotes endocrine system http://purl.obolibrary.org/obo/UBERON_0000949
T103 6019-6046 Body_part denotes female reproductive systems http://purl.obolibrary.org/obo/UBERON_0000474
T104 6057-6063 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T105 6302-6308 Body_part denotes stroma http://purl.obolibrary.org/obo/UBERON_0003891
T106 6682-6686 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T107 6718-6728 Body_part denotes cell layer http://purl.obolibrary.org/obo/UBERON_0000119
T108 6769-6779 Body_part denotes cell layer http://purl.obolibrary.org/obo/UBERON_0000119
T109 6783-6797 Body_part denotes hair follicles http://purl.obolibrary.org/obo/UBERON_0002073
T110 6835-6851 Body_part denotes sebaceous glands http://purl.obolibrary.org/obo/UBERON_0001821
T111 6923-6938 Body_part denotes sebaceous gland http://purl.obolibrary.org/obo/UBERON_0001821
T112 7119-7125 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T113 7152-7166 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
561 53-57 Gene denotes ACE2 Gene:59272
562 169-173 Gene denotes ACE2 Gene:59272
563 396-400 Gene denotes ACE2 Gene:59272
564 705-709 Gene denotes ACE2 Gene:59272
565 1185-1189 Gene denotes ACE2 Gene:59272
566 1231-1235 Gene denotes ACE2 Gene:59272
567 374-375 Gene denotes S Gene:43740568
568 120-129 Species denotes mammalian Tax:9606
569 1287-1292 Species denotes human Tax:9606
570 206-227 Disease denotes cardiovascular system MESH:D002318
571 1293-1308 Disease denotes hemato-lymphoid MESH:D008224
575 1564-1568 Gene denotes ACE2 Gene:59272
576 1910-1914 Gene denotes ACE2 Gene:59272
577 1897-1902 Species denotes human Tax:9606
581 2102-2106 Gene denotes ACE2 Gene:59272
582 2148-2157 Species denotes mammalian Tax:9606
583 2169-2174 Species denotes human Tax:9606
599 2774-2778 Gene denotes ACE2 Gene:59272
600 2917-2921 Gene denotes ACE2 Gene:59272
601 3345-3349 Gene denotes ACE2 Gene:59272
602 3397-3401 Gene denotes ACE2 Gene:59272
603 3559-3563 Gene denotes ACE2 Gene:70008
604 3946-3949 Gene denotes age Gene:5973
605 3866-3869 Gene denotes age Gene:5973
606 2938-2943 Species denotes human Tax:9606
607 3270-3280 Species denotes SARS-CoV-2 Tax:2697049
608 3662-3667 Species denotes mouse Tax:10090
609 3669-3672 Species denotes rat Tax:10116
610 3679-3685 Species denotes ferret Tax:9669
611 3698-3703 Species denotes human Tax:9606
612 3289-3298 Disease denotes infection MESH:D007239
613 3354-3362 Disease denotes COVID-19 MESH:C000657245
620 4016-4020 Gene denotes ACE2 Gene:59272
621 4281-4285 Gene denotes ACE2 Gene:59272
622 4693-4697 Gene denotes ACE2 Gene:59272
623 4464-4469 Disease denotes colon MESH:D003110
624 4532-4537 Disease denotes colon MESH:D003110
625 4737-4757 Disease denotes endocrine pancreatic MESH:D010195
634 4848-4852 Gene denotes ACE2 Gene:70008
635 4952-4956 Gene denotes ACE2 Gene:70008
636 5630-5634 Gene denotes ACE2 Gene:70008
637 5781-5785 Gene denotes ACE2 Gene:70008
638 4887-4892 Species denotes mouse Tax:10090
639 4909-4922 Disease denotes telencephalon
640 5151-5179 Disease denotes hypothalamic paraventricular MESH:D007027
641 5194-5202 Disease denotes postrema
648 5976-5980 Gene denotes ACE2 Gene:59272
649 6065-6069 Gene denotes ACE2 Gene:59272
650 6212-6216 Gene denotes ACE2 Gene:59272
651 6051-6056 Species denotes human Tax:9606
652 6239-6244 Species denotes human Tax:9606
653 6245-6252 Disease denotes ovaries MESH:D010051
656 6470-6474 Gene denotes ACE2 Gene:59272
657 6601-6606 Species denotes human Tax:9606
666 6688-6692 Gene denotes ACE2 Gene:59272
667 6875-6879 Gene denotes ACE2 Gene:59272
668 6985-6989 Gene denotes ACE2 Gene:59272
669 7053-7057 Gene denotes ACE2 Gene:59272
670 7222-7226 Gene denotes ACE2 Gene:59272
671 7080-7088 Gene denotes membrane Gene:43740571
672 6676-6681 Species denotes human Tax:9606
673 7092-7097 Species denotes human Tax:9606
995 374-375 Gene denotes S Gene:43740568

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1923 23-27 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1924 53-57 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1925 169-173 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1926 374-383 Protein denotes S Protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T1959 396-400 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1960 504-510 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1963 705-709 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1964 961-967 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1967 1185-1189 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1968 1231-1235 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1969 1564-1568 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1970 1910-1914 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1971 2102-2106 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1972 2774-2778 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1973 2917-2921 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1974 3345-3349 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1975 3397-3401 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1976 3444-3450 Protein denotes lamina https://www.uniprot.org/uniprot/P13648|https://www.uniprot.org/uniprot/P11048
T1978 3559-3563 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1979 4016-4020 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1980 4281-4285 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1981 4693-4697 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1982 4848-4852 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1983 4952-4956 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1984 5084-5090 Protein denotes lamina https://www.uniprot.org/uniprot/P13648|https://www.uniprot.org/uniprot/P11048
T1986 5630-5634 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1987 5781-5785 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1988 5976-5980 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1989 6065-6069 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1990 6212-6216 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1991 6470-6474 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1992 6688-6692 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1993 6799-6805 Protein denotes Smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1996 6875-6879 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1997 6985-6989 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1998 7053-7057 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1999 7222-7226 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T42 518-523 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T43 689-695 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T44 847-852 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T45 975-980 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T46 1309-1315 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T47 1405-1410 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T48 1411-1416 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T49 1775-1780 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T50 2448-2453 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T51 2809-2814 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T52 3142-3146 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T53 3289-3298 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T54 3475-3480 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T55 4155-4160 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T56 4477-4483 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T57 5026-5034 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T58 5075-5080 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T59 5115-5120 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T60 5445-5454 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T61 6026-6038 http://purl.obolibrary.org/obo/GO_0000003 denotes reproductive
T62 6110-6115 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T63 6153-6161 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T64 6331-6336 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T65 6545-6550 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T66 6718-6722 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T67 6769-6773 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T68 6813-6818 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T69 6939-6944 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T70 7002-7007 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T71 7102-7107 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T72 7119-7125 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T73 7247-7251 http://purl.obolibrary.org/obo/CL_0000000 denotes cell

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T97 0-6 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T98 58-65 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T99 105-112 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T100 206-227 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T101 232-238 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T102 376-383 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T103 441-452 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T104 474-482 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T105 487-492 Body_part denotes veins http://purl.org/sig/ont/fma/fma63814
T106 504-523 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T107 518-523 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T108 548-559 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T109 757-768 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T110 816-820 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T111 835-852 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T112 847-852 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T113 895-901 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T114 915-923 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T115 961-980 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T116 975-980 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 988-993 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T118 1049-1058 Body_part denotes mesangium http://purl.org/sig/ont/fma/fma84139
T119 1074-1085 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T120 1093-1099 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T121 1135-1144 Body_part denotes sinusoids http://purl.org/sig/ont/fma/fma63131
T122 1152-1157 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T123 1265-1281 Body_part denotes lymphatic system http://purl.org/sig/ont/fma/fma7162
T124 1323-1329 Body_part denotes spleen http://purl.org/sig/ont/fma/fma7196
T125 1331-1342 Body_part denotes lymph nodes http://purl.org/sig/ont/fma/fma5034
T126 1331-1336 Body_part denotes lymph http://purl.org/sig/ont/fma/fma9671
T127 1348-1359 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608
T128 1405-1410 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T129 1411-1416 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T130 1442-1451 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T131 1456-1467 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T132 1486-1499 Body_part denotes T lymphocytes http://purl.org/sig/ont/fma/fma62870
T133 1605-1610 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T134 1741-1755 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T135 1775-1780 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T136 1788-1803 Body_part denotes sinoatrial node http://purl.org/sig/ont/fma/fma9477
T137 1903-1908 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T138 1972-1985 Body_part denotes aortic valves http://purl.org/sig/ont/fma/fma7236
T139 2036-2050 Body_part denotes myofibroblasts http://purl.org/sig/ont/fma/fma0326458
T140 2055-2066 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T141 2107-2114 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T142 2176-2182 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T143 2411-2423 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T144 2448-2453 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 2521-2533 Body_part denotes Henle’s loop http://purl.org/sig/ont/fma/fma17698
T146 2566-2570 Body_part denotes duct http://purl.org/sig/ont/fma/fma30320
T147 2721-2738 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T148 2835-2846 Body_part denotes oral mucosa http://purl.org/sig/ont/fma/fma59660
T149 2840-2846 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T150 2855-2861 Body_part denotes larynx http://purl.org/sig/ont/fma/fma55097
T151 2863-2870 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T152 2884-2888 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T153 2959-2969 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T154 3118-3122 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T155 3142-3146 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T156 3147-3150 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T157 3259-3266 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T158 3373-3396 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T159 3444-3458 Body_part denotes lamina propria http://purl.org/sig/ont/fma/fma62517
T160 3468-3480 Body_part denotes muscle cells http://purl.org/sig/ont/fma/fma67328
T161 3475-3480 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T162 3492-3511 Body_part denotes salivary gland duct http://purl.org/sig/ont/fma/fma59908
T163 3512-3522 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T164 3531-3535 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T165 3564-3571 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T166 3620-3631 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T167 4053-4058 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T168 4104-4115 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T169 4134-4143 Body_part denotes bile duct http://purl.org/sig/ont/fma/fma9706
T170 4144-4160 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T171 4155-4160 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T172 4205-4216 Body_part denotes hepatocytes http://purl.org/sig/ont/fma/fma14515
T173 4286-4293 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 4325-4337 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T175 4341-4352 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T176 4373-4388 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T177 4404-4412 Body_part denotes duodenum http://purl.org/sig/ont/fma/fma7206
T178 4414-4421 Body_part denotes jejunum http://purl.org/sig/ont/fma/fma7207
T179 4427-4432 Body_part denotes ileum http://purl.org/sig/ont/fma/fma7208
T180 4445-4456 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T181 4464-4469 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T182 4491-4506 Body_part denotes digestive tract http://purl.org/sig/ont/fma/fma317863
T183 4520-4527 Body_part denotes stomach http://purl.org/sig/ont/fma/fma7148
T184 4532-4537 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T185 4552-4564 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T186 4622-4629 Body_part denotes mucosae http://purl.org/sig/ont/fma/fma85355
T187 4758-4764 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T188 4786-4806 Body_part denotes islets of Langerhans http://purl.org/sig/ont/fma/fma76489
T189 4893-4898 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T190 4909-4922 Body_part denotes telencephalon http://purl.org/sig/ont/fma/fma62000
T191 4930-4937 Body_part denotes medulla http://purl.org/sig/ont/fma/fma61108
T192 4969-4974 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T193 5066-5101 Body_part denotes vascular organ of lamina terminalis http://purl.org/sig/ont/fma/fma62315
T194 5103-5120 Body_part denotes subfornical organ http://purl.org/sig/ont/fma/fma75260
T195 5136-5143 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T196 5164-5187 Body_part denotes paraventricular nucleus http://purl.org/sig/ont/fma/fma62320
T197 5189-5202 Body_part denotes area postrema http://purl.org/sig/ont/fma/fma72607
T198 5204-5233 Body_part denotes nucleus of the solitary tract http://purl.org/sig/ont/fma/fma256691
T199 5219-5233 Body_part denotes solitary tract http://purl.org/sig/ont/fma/fma72619
T200 5263-5268 Body_part denotes vagus http://purl.org/sig/ont/fma/fma5731
T201 5315-5322 Body_part denotes medulla http://purl.org/sig/ont/fma/fma61108
T202 5404-5409 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T203 5488-5494 Body_part denotes cortex http://purl.org/sig/ont/fma/fma61109
T204 5496-5507 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T205 5517-5524 Body_part denotes putamen http://purl.org/sig/ont/fma/fma61834
T206 5526-5545 Body_part denotes hypoglossal nucleus http://purl.org/sig/ont/fma/fma54505
T207 5550-5570 Body_part denotes primary motor cortex http://purl.org/sig/ont/fma/fma224854
T208 5668-5675 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T209 5687-5697 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T210 5813-5819 Body_part denotes retina http://purl.org/sig/ont/fma/fma58301
T211 5874-5888 Body_part denotes photoreceptors http://purl.org/sig/ont/fma/fma85613
T212 5958-5974 Body_part denotes endocrine system http://purl.org/sig/ont/fma/fma9668
T213 6026-6046 Body_part denotes reproductive systems http://purl.org/sig/ont/fma/fma7160
T214 6057-6063 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T215 6102-6115 Body_part denotes Sertoli cells http://purl.org/sig/ont/fma/fma72298
T216 6110-6115 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T217 6217-6224 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T218 6302-6308 Body_part denotes stroma http://purl.org/sig/ont/fma/fma81494
T219 6321-6336 Body_part denotes granulosa cells http://purl.org/sig/ont/fma/fma18718
T220 6331-6336 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T221 6491-6502 Body_part denotes osteoblasts http://purl.org/sig/ont/fma/fma66780
T222 6507-6518 Body_part denotes osteoclasts http://purl.org/sig/ont/fma/fma66781
T223 6534-6550 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T224 6545-6550 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T225 6555-6566 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T226 6682-6686 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T227 6712-6745 Body_part denotes basal cell layer of the epidermis http://purl.org/sig/ont/fma/fma67540
T228 6712-6722 Body_part denotes basal cell http://purl.org/sig/ont/fma/fma62516
T229 6718-6722 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T230 6736-6745 Body_part denotes epidermis http://purl.org/sig/ont/fma/fma70596
T231 6763-6773 Body_part denotes basal cell http://purl.org/sig/ont/fma/fma62516
T232 6769-6773 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T233 6783-6797 Body_part denotes hair follicles http://purl.org/sig/ont/fma/fma70660
T234 6799-6818 Body_part denotes Smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T235 6813-6818 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T236 6835-6851 Body_part denotes sebaceous glands http://purl.org/sig/ont/fma/fma71874
T237 6886-6897 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T238 6923-6938 Body_part denotes sebaceous gland http://purl.org/sig/ont/fma/fma59160
T239 6939-6944 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T240 7002-7007 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T241 7015-7029 Body_part denotes eccrine glands http://purl.org/sig/ont/fma/fma59154
T242 7023-7029 Body_part denotes glands http://purl.org/sig/ont/fma/fma71481
T243 7098-7107 Body_part denotes fat cells http://purl.org/sig/ont/fma/fma63880
T244 7102-7107 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T245 7152-7166 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T246 7247-7261 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T247 7247-7251 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T57 3270-3280 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T58 3270-3274 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 3289-3298 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 3354-3362 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T27 206-227 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T28 232-238 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T29 441-452 http://purl.obolibrary.org/obo/MAT_0000393 denotes vasculature
T30 474-482 http://purl.obolibrary.org/obo/MAT_0000034 denotes arteries
T31 487-492 http://purl.obolibrary.org/obo/MAT_0000037 denotes veins
T32 504-517 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T33 511-517 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T34 623-630 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T35 734-741 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T36 816-820 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T37 895-901 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T38 915-923 http://purl.obolibrary.org/obo/MAT_0000034 denotes arteries
T39 961-974 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T40 968-974 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T41 988-993 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T42 1093-1099 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T43 1152-1157 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T44 1265-1281 http://purl.obolibrary.org/obo/MAT_0000197 denotes lymphatic system
T45 1323-1329 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T46 1331-1342 http://purl.obolibrary.org/obo/MAT_0000197 denotes lymph nodes
T47 1331-1342 http://purl.obolibrary.org/obo/MAT_0000442 denotes lymph nodes
T48 1331-1336 http://purl.obolibrary.org/obo/MAT_0000055 denotes lymph
T49 1348-1359 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow
T50 1348-1352 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T51 1405-1416 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood cells
T52 1405-1410 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T53 1605-1610 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T54 1676-1682 http://purl.obolibrary.org/obo/MAT_0000496 denotes atrium
T55 1686-1695 http://purl.obolibrary.org/obo/MAT_0000497 denotes ventricle
T56 1903-1908 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T57 2176-2182 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T58 2431-2439 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T59 2855-2861 http://purl.obolibrary.org/obo/MAT_0000187 denotes larynx
T60 2863-2870 http://purl.obolibrary.org/obo/MAT_0000137 denotes trachea
T61 2884-2888 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T62 3468-3474 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T63 3492-3506 http://purl.obolibrary.org/obo/MAT_0000079 denotes salivary gland
T64 3501-3506 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland
T65 3531-3535 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T66 3953-3958 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T67 4053-4058 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T68 4097-4103 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessel
T69 4373-4388 http://purl.obolibrary.org/obo/MAT_0000047 denotes small intestine
T70 4379-4388 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestine
T71 4404-4412 http://purl.obolibrary.org/obo/MAT_0000044 denotes duodenum
T72 4414-4421 http://purl.obolibrary.org/obo/MAT_0000045 denotes jejunum
T73 4427-4432 http://purl.obolibrary.org/obo/MAT_0000282 denotes ileum
T74 4464-4469 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T75 4520-4527 http://purl.obolibrary.org/obo/MAT_0000051 denotes stomach
T76 4532-4537 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T77 4786-4806 http://purl.obolibrary.org/obo/MAT_0000076 denotes islets of Langerhans
T78 4893-4898 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T79 4909-4922 http://purl.obolibrary.org/obo/MAT_0000421 denotes telencephalon
T80 4969-4974 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T81 5235-5241 http://purl.obolibrary.org/obo/MAT_0000487 denotes dorsal
T82 5404-5409 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T83 5496-5507 http://purl.obolibrary.org/obo/MAT_0000114 denotes hippocampus
T84 5813-5819 http://purl.obolibrary.org/obo/MAT_0000142 denotes retina
T85 5958-5974 http://purl.obolibrary.org/obo/MAT_0000021 denotes endocrine system
T86 6010-6014 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T87 6019-6046 http://purl.obolibrary.org/obo/MAT_0000028 denotes female reproductive systems
T88 6057-6063 http://purl.obolibrary.org/obo/MAT_0000132 denotes testis
T89 6464-6468 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T90 6682-6686 http://purl.obolibrary.org/obo/MAT_0000284 denotes skin
T91 6736-6745 http://purl.obolibrary.org/obo/MAT_0000154 denotes epidermis
T92 6783-6787 http://purl.obolibrary.org/obo/MAT_0000160 denotes hair
T93 6799-6812 http://purl.obolibrary.org/obo/MAT_0000303 denotes Smooth muscle
T94 6806-6812 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T95 6845-6851 http://purl.obolibrary.org/obo/MAT_0000021 denotes glands
T96 6933-6938 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland
T97 7023-7029 http://purl.obolibrary.org/obo/MAT_0000021 denotes glands
T98 7152-7166 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T63 299-322 http://purl.obolibrary.org/obo/GO_0050801 denotes electrolyte homeostasis
T64 311-322 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T65 4997-5007 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T65 299-322 http://purl.obolibrary.org/obo/GO_0050801 denotes electrolyte homeostasis
T66 311-322 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T67 4997-5007 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
561 53-57 Gene denotes ACE2 Gene:59272
562 169-173 Gene denotes ACE2 Gene:59272
563 396-400 Gene denotes ACE2 Gene:59272
564 705-709 Gene denotes ACE2 Gene:59272
565 1185-1189 Gene denotes ACE2 Gene:59272
566 1231-1235 Gene denotes ACE2 Gene:59272
567 374-375 Gene denotes S Gene:43740568
568 120-129 Species denotes mammalian Tax:9606
569 1287-1292 Species denotes human Tax:9606
570 206-227 Disease denotes cardiovascular system MESH:D002318
571 1293-1308 Disease denotes hemato-lymphoid MESH:D008224
575 1564-1568 Gene denotes ACE2 Gene:59272
576 1910-1914 Gene denotes ACE2 Gene:59272
577 1897-1902 Species denotes human Tax:9606
581 2102-2106 Gene denotes ACE2 Gene:59272
582 2148-2157 Species denotes mammalian Tax:9606
583 2169-2174 Species denotes human Tax:9606
599 2774-2778 Gene denotes ACE2 Gene:59272
600 2917-2921 Gene denotes ACE2 Gene:59272
601 3345-3349 Gene denotes ACE2 Gene:59272
602 3397-3401 Gene denotes ACE2 Gene:59272
603 3559-3563 Gene denotes ACE2 Gene:70008
604 3946-3949 Gene denotes age Gene:5973
605 3866-3869 Gene denotes age Gene:5973
606 2938-2943 Species denotes human Tax:9606
607 3270-3280 Species denotes SARS-CoV-2 Tax:2697049
608 3662-3667 Species denotes mouse Tax:10090
609 3669-3672 Species denotes rat Tax:10116
610 3679-3685 Species denotes ferret Tax:9669
611 3698-3703 Species denotes human Tax:9606
612 3289-3298 Disease denotes infection MESH:D007239
613 3354-3362 Disease denotes COVID-19 MESH:C000657245
620 4016-4020 Gene denotes ACE2 Gene:59272
621 4281-4285 Gene denotes ACE2 Gene:59272
622 4693-4697 Gene denotes ACE2 Gene:59272
623 4464-4469 Disease denotes colon MESH:D003110
624 4532-4537 Disease denotes colon MESH:D003110
625 4737-4757 Disease denotes endocrine pancreatic MESH:D010195
634 4848-4852 Gene denotes ACE2 Gene:70008
635 4952-4956 Gene denotes ACE2 Gene:70008
636 5630-5634 Gene denotes ACE2 Gene:70008
637 5781-5785 Gene denotes ACE2 Gene:70008
638 4887-4892 Species denotes mouse Tax:10090
639 4909-4922 Disease denotes telencephalon
640 5151-5179 Disease denotes hypothalamic paraventricular MESH:D007027
641 5194-5202 Disease denotes postrema
648 5976-5980 Gene denotes ACE2 Gene:59272
649 6065-6069 Gene denotes ACE2 Gene:59272
650 6212-6216 Gene denotes ACE2 Gene:59272
651 6051-6056 Species denotes human Tax:9606
652 6239-6244 Species denotes human Tax:9606
653 6245-6252 Disease denotes ovaries MESH:D010051
656 6470-6474 Gene denotes ACE2 Gene:59272
657 6601-6606 Species denotes human Tax:9606
666 6688-6692 Gene denotes ACE2 Gene:59272
667 6875-6879 Gene denotes ACE2 Gene:59272
668 6985-6989 Gene denotes ACE2 Gene:59272
669 7053-7057 Gene denotes ACE2 Gene:59272
670 7222-7226 Gene denotes ACE2 Gene:59272
671 7080-7088 Gene denotes membrane Gene:43740571
672 6676-6681 Species denotes human Tax:9606
673 7092-7097 Species denotes human Tax:9606

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T124 0-27 Sentence denotes Tissue Distribution of ACE2
T125 28-168 Sentence denotes Detectable quantities of ACE2 protein have been found almost ubiquitously in tissues across mammalian species, using immunostaining methods.
T126 169-386 Sentence denotes ACE2 is predominantly located in the cardiovascular system and kidney, where it probably plays a role in the maintenance of hydro electrolyte homeostasis (section “Mechanism of Viral Entry Mediated by the S Protein”).
T127 387-605 Sentence denotes In fact, ACE2 is pervasively expressed throughout the vasculature, at the level of the arteries and veins, mainly in smooth muscle cells of the media and in the endothelium (Hamming et al., 2004; Burrell et al., 2005).
T128 606-696 Sentence denotes Such signal from vessels also delivers part of the expression detected in specific organs.
T129 697-1035 Sentence denotes Indeed, ACE2 is evident in: coronary vessels and myocardial capillaries (Wiener et al., 2007; Garabelli et al., 2008); lung microvascular endothelial cells (Wiener et al., 2007; Chen et al., 2013); kidney interlobular arteries (Lely et al., 2004); endothelial and smooth muscle cells in the brain (Hamming et al., 2004; Kar et al., 2010).
T130 1036-1213 Sentence denotes Notably, the mesangium and glomerular endothelium in the kidney, and the endothelial lining of the sinusoids in the liver are allegedly negative for ACE2 (Hamming et al., 2004).
T131 1214-1401 Sentence denotes On the contrary, ACE2 is virtually absent from the lymphatic system, and human hemato-lymphoid organs (i.e., spleen, lymph nodes, and bone marrow) (Hamming et al., 2004; Li et al., 2007).
T132 1402-1549 Sentence denotes In blood cells, it has been observed in platelets and macrophages, but not in B and T lymphocytes (Hamming et al., 2004; Fraga-Silva et al., 2011).
T133 1550-1893 Sentence denotes Expression of ACE2 was originally identified in rodent heart (Donoghue et al., 2000a), where it was observed to occur in both atrium an ventricle (Gembardt et al., 2005), and, cellularly, in cardiomyocytes and in specialized cells of the sinoatrial node (Burrell et al., 2005; Garabelli et al., 2008; Ferreira et al., 2011; Wang et al., 2017).
T134 1894-2086 Sentence denotes In human heart, ACE2 has been found in the stromal area in spongiosa layer in aortic valves (Peltonen et al., 2011), where it is expressed in myofibroblasts and fibroblasts (Guy et al., 2008).
T135 2087-2374 Sentence denotes High levels of ACE2 protein expression have been detected in mammalian, including human, kidney (Gembardt et al., 2005; Koka et al., 2008; Reich et al., 2008; Giani et al., 2012; Mitani et al., 2014; Grobe et al., 2015; Shi et al., 2015; Larouche-Lebel et al., 2019; Alawi et al., 2020).
T136 2375-2713 Sentence denotes Strong signals were reported in the brush border of the proximal tubular cells, whereas weak to moderate signals could be found in the glomeruli, Henle’s loop, distal tubules, and collecting duct (Hamming et al., 2004; Lely et al., 2004; Kamilic et al., 2010; Giani et al., 2012; Bae et al., 2015; Cao et al., 2017; Errarte et al., 2017).
T137 2714-2908 Sentence denotes In the respiratory tract of primates, positive labeling for ACE2 has been reported at multiple sites, from the nasal and oral mucosa, to the larynx, trachea, bronchi and lung (Liu et al., 2011).
T138 2909-3194 Sentence denotes Whether ACE2 is expressed in human nasal and oral epithelium remains unclear, as contradictory results have been reported by studies using immunohistochemistry (Hamming et al., 2004; Bertram et al., 2012), in face of positive single-cell RNA sequencing findings (Sungnak et al., 2020).
T139 3195-3365 Sentence denotes This point is of great interest to understand the role of those tissues in SARS-CoV-2 initial infection, spread and clearance (section “Links Between ACE2 and COVID-19”).
T140 3366-3523 Sentence denotes In the upper respiratory tract ACE2 is expressed in the epithelial lining and lamina propria, in some muscle cells and in the salivary gland duct epithelium.
T141 3524-3818 Sentence denotes In the lung, an intense signal for ACE2 protein has been consistently observed in type I and II pneumocytes in several species, including mouse, rat, cat, ferret, monkey and human (Wiener et al., 2007; van den Brand et al., 2008; Liu et al., 2011; Wong et al., 2012; Chen et al., 2013; Zhang B.
T142 3819-3836 Sentence denotes N. et al., 2019).
T143 3837-4001 Sentence denotes Data from rodents suggest an age- and gender-dependent pattern of expression, with a more rapid decline with age in males as compared to females (Xie et al., 2006).
T144 4002-4280 Sentence denotes Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020).
T145 4281-4470 Sentence denotes ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon.
T146 4471-4680 Sentence denotes Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004).
T147 4681-4847 Sentence denotes In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010).
T148 4848-4938 Sentence denotes ACE2 distribution is widespread in the mouse brain, from the telencephalon to the medulla.
T149 4939-5345 Sentence denotes As expected, ACE2 is found in brain areas involved in the regulation of cardiovascular function and fluid balance, such as the vascular organ of lamina terminalis, subfornical organ, magnocellular neurons in the hypothalamic paraventricular nucleus, area postrema, nucleus of the solitary tract, dorsal motor nucleus of the vagus, nucleus ambiguous, and rostral ventrolateral medulla (Doobay et al., 2007).
T150 5346-5629 Sentence denotes However, significant expression had also been reported in brain areas not engaged in the classical functions of the RAAS, namely the piriform cortex, hippocampus, caudate putamen, hypoglossal nucleus and primary motor cortex (Doobay et al., 2007; Lin et al., 2008; Liu et al., 2014).
T151 5630-5767 Sentence denotes ACE2 immunostaining was identified in neurons as well as astrocytes (Gallagher et al., 2006; Doobay et al., 2007; Yamazato et al., 2007).
T152 5768-5938 Sentence denotes Furthermore, ACE2 has been documented in the retina, predominantly in the inner nuclear layer but also in photoreceptors (Tikellis et al., 2004; Senanayake et al., 2007).
T153 5939-6047 Sentence denotes With regard to the endocrine system, ACE2 expression was found in both male and female reproductive systems.
T154 6048-6185 Sentence denotes In human testis, ACE2 was localized to the Leydig and Sertoli cells, and might be involved in testicular function (Douglas et al., 2004).
T155 6186-6453 Sentence denotes At present, no data about ACE2 protein expression is human ovaries is available, although evidence of expression in stroma, theca, and granulosa cells has been reported in other species (Tonellotto dos Santos et al., 2012; Barreta et al., 2015; Pereira et al., 2015).
T156 6454-6567 Sentence denotes In rodent bone, ACE2 is expressed in osteoblasts and osteoclasts, as well as in epithelial cells and fibroblasts.
T157 6568-6672 Sentence denotes However, a similar expression in human samples still awaits clarification (Queiroz-Junior et al., 2019).
T158 6673-6798 Sentence denotes In human skin, ACE2 was present in the basal cell layer of the epidermis extending to the basal cell layer of hair follicles.
T159 6799-6880 Sentence denotes Smooth muscle cells surrounding the sebaceous glands were also positive for ACE2.
T160 6881-6945 Sentence denotes Weak cytoplasmic staining was observed in sebaceous gland cells.
T161 6946-7030 Sentence denotes A strong granular staining pattern for ACE2 was seen in cells of the eccrine glands.
T162 7031-7211 Sentence denotes Positive staining for ACE2 was also noted in the membrane of human fat cells in various organs, including the epicardial adipose tissue (Hamming et al., 2004; Patel et al., 2016a).
T163 7212-7322 Sentence denotes Globally, ACE2 is chiefly bound to cell membranes, while negligible levels can be detected in the circulation.