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PMC:7556165 / 16975-18067 JSON TXT

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LitCovid-sample-PD-NCBITaxon

Id	Subject	Object	Predicate	Lexical cue	ncbi_taxonomy_id
T46	1081-1091	Species	denotes	Sars-CoV-2	NCBItxid:2697049

LitCovid-sample-sentences

Id	Subject	Object	Predicate	Lexical cue
T112	0-215	Sentence	denotes	Beside undergoing post-translational modifications by glycosylation and phosphorylation, ACE2 is also post-translationally regulated by shedding from cell membrane through the action of the metalloproteinase ADAM17.
T113	216-386	Sentence	denotes	The proteolysis of ACE2 releases a soluble, enzymatically active form which corresponds to the ACE2 ectodomain (Jia et al., 2009; Xiao et al., 2014; Conrad et al., 2016).
T114	387-504	Sentence	denotes	The function, if any, of soluble ACE2 is still obscure, but the shedding mechanism is under strict molecular control.
T115	505-667	Sentence	denotes	Lambert et al. (2008) highlighted that calmodulin associates with ACE2 to prevent its shedding, while calmodulin inhibitors increase the cellular release of ACE2.
T116	668-717	Sentence	denotes	Patel identified a positive feedback in the RAAS:
T117	718-828	Sentence	denotes	Ang II activates ADAM17, thereby increasing the release of ACE2, its negative regulator (Patel et al., 2016b).
T118	829-960	Sentence	denotes	It is worth noting that high levels of plasma-soluble ACE2 have been associated with myocardial dysfunction (Epelman et al., 2009).
T119	961-1092	Sentence	denotes	The potential pathophysiological role of ADAM17 is further discussed in paragraph ACE2 and the Inflammatory Response to Sars-CoV-2.

LitCovid-sample-Pubtator

Id	Subject	Object	Predicate	Lexical cue	pubann:denotes
521	89-93	Gene	denotes	ACE2	Gene:59272
522	235-239	Gene	denotes	ACE2	Gene:59272
523	311-315	Gene	denotes	ACE2	Gene:59272
524	420-424	Gene	denotes	ACE2	Gene:59272
525	571-575	Gene	denotes	ACE2	Gene:59272
526	662-666	Gene	denotes	ACE2	Gene:59272
527	718-724	Gene	denotes	Ang II	Gene:24179
528	735-741	Gene	denotes	ADAM17	Gene:6868
529	777-781	Gene	denotes	ACE2	Gene:59272
530	883-887	Gene	denotes	ACE2	Gene:59272
531	1002-1008	Gene	denotes	ADAM17	Gene:6868
532	1043-1047	Gene	denotes	ACE2	Gene:59272
533	607-617	Gene	denotes	calmodulin	Gene:801
534	544-554	Gene	denotes	calmodulin	Gene:801
535	102-106	Gene	denotes	post	Gene:159371
536	18-22	Gene	denotes	post	Gene:159371
537	155-163	Gene	denotes	membrane	Gene:43740571
538	1081-1091	Species	denotes	Sars-CoV-2	Tax:2697049
539	914-936	Disease	denotes	myocardial dysfunction	MESH:D009202

LitCovid-sample-UniProt

Id	Subject	Object	Predicate	Lexical cue	uniprot_id
T1795	89-93	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T1796	208-214	Protein	denotes	ADAM17	https://www.uniprot.org/uniprot/Q9Z1K9\|https://www.uniprot.org/uniprot/Q9Z0K3\|https://www.uniprot.org/uniprot/Q9Z0F8\|https://www.uniprot.org/uniprot/Q9R1U4\|https://www.uniprot.org/uniprot/Q505A7\|https://www.uniprot.org/uniprot/P78536\|https://www.uniprot.org/uniprot/O88726\|https://www.uniprot.org/uniprot/O77636\|https://www.uniprot.org/uniprot/O60226
T1805	235-239	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T1806	311-315	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T1807	420-424	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T1808	544-554	Protein	denotes	calmodulin	https://www.uniprot.org/uniprot/Q90496\|https://www.uniprot.org/uniprot/Q8STF0\|https://www.uniprot.org/uniprot/Q7T3T2\|https://www.uniprot.org/uniprot/Q71UH6\|https://www.uniprot.org/uniprot/Q6YNX6\|https://www.uniprot.org/uniprot/Q6R520\|https://www.uniprot.org/uniprot/Q6PI52\|https://www.uniprot.org/uniprot/Q6IT78\|https://www.uniprot.org/uniprot/Q61380\|https://www.uniprot.org/uniprot/Q61379\|https://www.uniprot.org/uniprot/Q5ZIQ6\|https://www.uniprot.org/uniprot/Q5RAD2\|https://www.uniprot.org/uniprot/Q4V949\|https://www.uniprot.org/uniprot/Q2KJE6\|https://www.uniprot.org/uniprot/Q08D84\|https://www.uniprot.org/uniprot/P99014\|https://www.uniprot.org/uniprot/P70667\|https://www.uniprot.org/uniprot/P62184\|https://www.uniprot.org/uniprot/P62160\|https://www.uniprot.org/uniprot/P62157\|https://www.uniprot.org/uniprot/P62156\|https://www.uniprot.org/uniprot/P62154\|https://www.uniprot.org/uniprot/P62152\|https://www.uniprot.org/uniprot/P62151\|https://www.uniprot.org/uniprot/P62149\|https://www.uniprot.org/uniprot/P62145\|https://www.uniprot.org/uniprot/P62144\|https://www.uniprot.org/uniprot/P21251\|https://www.uniprot.org/uniprot/P11121\|https://www.uniprot.org/uniprot/P07181\|https://www.uniprot.org/uniprot/P05935\|https://www.uniprot.org/uniprot/P05934\|https://www.uniprot.org/uniprot/P02596\|https://www.uniprot.org/uniprot/P02595\|https://www.uniprot.org/uniprot/P02594\|https://www.uniprot.org/uniprot/P02593\|https://www.uniprot.org/uniprot/O97341\|https://www.uniprot.org/uniprot/O16305\|https://www.uniprot.org/uniprot/O02367\|https://www.uniprot.org/uniprot/Q9V3T4\|https://www.uniprot.org/uniprot/Q9U6D3\|https://www.uniprot.org/uniprot/Q9NDV6\|https://www.uniprot.org/uniprot/Q9GRJ1\|https://www.uniprot.org/uniprot/Q95NR9\|https://www.uniprot.org/uniprot/Q95NI4
T1853	571-575	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T1854	607-617	Protein	denotes	calmodulin	https://www.uniprot.org/uniprot/Q90496\|https://www.uniprot.org/uniprot/Q8STF0\|https://www.uniprot.org/uniprot/Q7T3T2\|https://www.uniprot.org/uniprot/Q71UH6\|https://www.uniprot.org/uniprot/Q6YNX6\|https://www.uniprot.org/uniprot/Q6R520\|https://www.uniprot.org/uniprot/Q6PI52\|https://www.uniprot.org/uniprot/Q6IT78\|https://www.uniprot.org/uniprot/Q61380\|https://www.uniprot.org/uniprot/Q61379\|https://www.uniprot.org/uniprot/Q5ZIQ6\|https://www.uniprot.org/uniprot/Q5RAD2\|https://www.uniprot.org/uniprot/Q4V949\|https://www.uniprot.org/uniprot/Q2KJE6\|https://www.uniprot.org/uniprot/Q08D84\|https://www.uniprot.org/uniprot/P99014\|https://www.uniprot.org/uniprot/P70667\|https://www.uniprot.org/uniprot/P62184\|https://www.uniprot.org/uniprot/P62160\|https://www.uniprot.org/uniprot/P62157\|https://www.uniprot.org/uniprot/P62156\|https://www.uniprot.org/uniprot/P62154\|https://www.uniprot.org/uniprot/P62152\|https://www.uniprot.org/uniprot/P62151\|https://www.uniprot.org/uniprot/P62149\|https://www.uniprot.org/uniprot/P62145\|https://www.uniprot.org/uniprot/P62144\|https://www.uniprot.org/uniprot/P21251\|https://www.uniprot.org/uniprot/P11121\|https://www.uniprot.org/uniprot/P07181\|https://www.uniprot.org/uniprot/P05935\|https://www.uniprot.org/uniprot/P05934\|https://www.uniprot.org/uniprot/P02596\|https://www.uniprot.org/uniprot/P02595\|https://www.uniprot.org/uniprot/P02594\|https://www.uniprot.org/uniprot/P02593\|https://www.uniprot.org/uniprot/O97341\|https://www.uniprot.org/uniprot/O16305\|https://www.uniprot.org/uniprot/O02367\|https://www.uniprot.org/uniprot/Q9V3T4\|https://www.uniprot.org/uniprot/Q9U6D3\|https://www.uniprot.org/uniprot/Q9NDV6\|https://www.uniprot.org/uniprot/Q9GRJ1\|https://www.uniprot.org/uniprot/Q95NR9\|https://www.uniprot.org/uniprot/Q95NI4
T1899	662-666	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T1900	735-741	Protein	denotes	ADAM17	https://www.uniprot.org/uniprot/Q9Z1K9\|https://www.uniprot.org/uniprot/Q9Z0K3\|https://www.uniprot.org/uniprot/Q9Z0F8\|https://www.uniprot.org/uniprot/Q9R1U4\|https://www.uniprot.org/uniprot/Q505A7\|https://www.uniprot.org/uniprot/P78536\|https://www.uniprot.org/uniprot/O88726\|https://www.uniprot.org/uniprot/O77636\|https://www.uniprot.org/uniprot/O60226
T1909	777-781	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T1910	883-887	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6
T1911	1002-1008	Protein	denotes	ADAM17	https://www.uniprot.org/uniprot/Q9Z1K9\|https://www.uniprot.org/uniprot/Q9Z0K3\|https://www.uniprot.org/uniprot/Q9Z0F8\|https://www.uniprot.org/uniprot/Q9R1U4\|https://www.uniprot.org/uniprot/Q505A7\|https://www.uniprot.org/uniprot/P78536\|https://www.uniprot.org/uniprot/O88726\|https://www.uniprot.org/uniprot/O77636\|https://www.uniprot.org/uniprot/O60226
T1920	1043-1047	Protein	denotes	ACE2	https://www.uniprot.org/uniprot/Q9UFZ6

LitCovid-sample-PD-IDO

Id	Subject	Object	Predicate	Lexical cue
T40	150-154	http://purl.obolibrary.org/obo/CL_0000000	denotes	cell
T41	391-399	http://purl.obolibrary.org/obo/BFO_0000034	denotes	function

LitCovid-sample-PD-FMA

Id	Subject	Object	Predicate	Lexical cue	fma_id
T92	150-163	Body_part	denotes	cell membrane	http://purl.org/sig/ont/fma/fma63841
T93	150-154	Body_part	denotes	cell	http://purl.org/sig/ont/fma/fma68646
T94	544-554	Body_part	denotes	calmodulin	http://purl.org/sig/ont/fma/fma62343
T95	607-617	Body_part	denotes	calmodulin	http://purl.org/sig/ont/fma/fma62343
T96	868-874	Body_part	denotes	plasma	http://purl.org/sig/ont/fma/fma62970

LitCovid-sample-PD-MONDO

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T56	1081-1091	Disease	denotes	Sars-CoV-2	http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-GO-BP-0

Id	Subject	Object	Predicate	Lexical cue
T49	18-50	http://purl.obolibrary.org/obo/GO_0043687	denotes	post-translational modifications
T50	54-67	http://purl.obolibrary.org/obo/GO_0070085	denotes	glycosylation
T51	72-87	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T52	107-122	http://purl.obolibrary.org/obo/GO_0006412	denotes	translationally
T53	220-231	http://purl.obolibrary.org/obo/GO_0006508	denotes	proteolysis
T54	1056-1077	http://purl.obolibrary.org/obo/GO_0006954	denotes	Inflammatory Response

LitCovid-sample-GO-BP

Id	Subject	Object	Predicate	Lexical cue
T51	18-50	http://purl.obolibrary.org/obo/GO_0043687	denotes	post-translational modifications
T52	54-67	http://purl.obolibrary.org/obo/GO_0070085	denotes	glycosylation
T53	72-87	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T54	107-122	http://purl.obolibrary.org/obo/GO_0006412	denotes	translationally
T55	220-231	http://purl.obolibrary.org/obo/GO_0006508	denotes	proteolysis
T56	1056-1077	http://purl.obolibrary.org/obo/GO_0006954	denotes	Inflammatory Response

LitCovid-PubTator

Id	Subject	Object	Predicate	Lexical cue	tao:has_database_id
521	89-93	Gene	denotes	ACE2	Gene:59272
522	235-239	Gene	denotes	ACE2	Gene:59272
523	311-315	Gene	denotes	ACE2	Gene:59272
524	420-424	Gene	denotes	ACE2	Gene:59272
525	571-575	Gene	denotes	ACE2	Gene:59272
526	662-666	Gene	denotes	ACE2	Gene:59272
527	718-724	Gene	denotes	Ang II	Gene:24179
528	735-741	Gene	denotes	ADAM17	Gene:6868
529	777-781	Gene	denotes	ACE2	Gene:59272
530	883-887	Gene	denotes	ACE2	Gene:59272
531	1002-1008	Gene	denotes	ADAM17	Gene:6868
532	1043-1047	Gene	denotes	ACE2	Gene:59272
533	607-617	Gene	denotes	calmodulin	Gene:801
534	544-554	Gene	denotes	calmodulin	Gene:801
535	102-106	Gene	denotes	post	Gene:159371
536	18-22	Gene	denotes	post	Gene:159371
537	155-163	Gene	denotes	membrane	Gene:43740571
538	1081-1091	Species	denotes	Sars-CoV-2	Tax:2697049
539	914-936	Disease	denotes	myocardial dysfunction	MESH:D009202

LitCovid-sentences

Id	Subject	Object	Predicate	Lexical cue
T112	0-215	Sentence	denotes	Beside undergoing post-translational modifications by glycosylation and phosphorylation, ACE2 is also post-translationally regulated by shedding from cell membrane through the action of the metalloproteinase ADAM17.
T113	216-386	Sentence	denotes	The proteolysis of ACE2 releases a soluble, enzymatically active form which corresponds to the ACE2 ectodomain (Jia et al., 2009; Xiao et al., 2014; Conrad et al., 2016).
T114	387-504	Sentence	denotes	The function, if any, of soluble ACE2 is still obscure, but the shedding mechanism is under strict molecular control.
T115	505-667	Sentence	denotes	Lambert et al. (2008) highlighted that calmodulin associates with ACE2 to prevent its shedding, while calmodulin inhibitors increase the cellular release of ACE2.
T116	668-717	Sentence	denotes	Patel identified a positive feedback in the RAAS:
T117	718-828	Sentence	denotes	Ang II activates ADAM17, thereby increasing the release of ACE2, its negative regulator (Patel et al., 2016b).
T118	829-960	Sentence	denotes	It is worth noting that high levels of plasma-soluble ACE2 have been associated with myocardial dysfunction (Epelman et al., 2009).
T119	961-1092	Sentence	denotes	The potential pathophysiological role of ADAM17 is further discussed in paragraph ACE2 and the Inflammatory Response to Sars-CoV-2.