PMC:7556165 / 16240-16655 JSON TXT

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LitCovid-sample-MedDRA

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T58","span":{"begin":43,"end":46},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T59","span":{"begin":341,"end":344},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A58","pred":"meddra_id","subj":"T58","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A59","pred":"meddra_id","subj":"T59","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-CHEBI

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T77","span":{"begin":110,"end":118},"obj":"Chemical"}],"attributes":[{"id":"A77","pred":"chebi_id","subj":"T77","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-sentences

{"project":"LitCovid-sample-sentences","denotations":[{"id":"T107","span":{"begin":0,"end":119},"obj":"Sentence"},{"id":"T108","span":{"begin":120,"end":415},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-PD-UBERON

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T28","span":{"begin":409,"end":414},"obj":"Body_part"}],"attributes":[{"id":"A28","pred":"uberon_id","subj":"T28","obj":"http://purl.obolibrary.org/obo/UBERON_0000948"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-Pubtator

{"project":"LitCovid-sample-Pubtator","denotations":[{"id":"491","span":{"begin":336,"end":340},"obj":"Gene"},{"id":"487","span":{"begin":43,"end":46},"obj":"Gene"},{"id":"488","span":{"begin":47,"end":51},"obj":"Gene"},{"id":"489","span":{"begin":249,"end":253},"obj":"Gene"},{"id":"490","span":{"begin":282,"end":287},"obj":"Gene"},{"id":"492","span":{"begin":341,"end":344},"obj":"Gene"},{"id":"493","span":{"begin":382,"end":401},"obj":"Disease"}],"attributes":[{"id":"A488","pred":"pubann:denotes","subj":"488","obj":"Gene:59272"},{"id":"A490","pred":"pubann:denotes","subj":"490","obj":"Gene:2305"},{"id":"A489","pred":"pubann:denotes","subj":"489","obj":"Gene:6597"},{"id":"A487","pred":"pubann:denotes","subj":"487","obj":"Gene:1636"},{"id":"A493","pred":"pubann:denotes","subj":"493","obj":"MESH:D006332"},{"id":"A491","pred":"pubann:denotes","subj":"491","obj":"Gene:59272"},{"id":"A492","pred":"pubann:denotes","subj":"492","obj":"Gene:1636"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-UniProt

LitCovid-sample-PD-IDO

{"project":"LitCovid-sample-PD-IDO","denotations":[{"id":"T38","span":{"begin":232,"end":237},"obj":"http://purl.obolibrary.org/obo/CL_0000000"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-PD-FMA

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T85","span":{"begin":110,"end":118},"obj":"Body_part"},{"id":"T86","span":{"begin":220,"end":237},"obj":"Body_part"},{"id":"T87","span":{"begin":232,"end":237},"obj":"Body_part"},{"id":"T88","span":{"begin":254,"end":263},"obj":"Body_part"},{"id":"T89","span":{"begin":409,"end":414},"obj":"Body_part"}],"attributes":[{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma7088"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma67526"},{"id":"A86","pred":"fma_id","subj":"T86","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A85","pred":"fma_id","subj":"T85","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-PD-MAT

{"project":"LitCovid-sample-PD-MAT","denotations":[{"id":"T26","span":{"begin":409,"end":414},"obj":"http://purl.obolibrary.org/obo/MAT_0000036"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-PD-GO-BP-0

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T41","span":{"begin":72,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0003712"},{"id":"T42","span":{"begin":91,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T43","span":{"begin":254,"end":273},"obj":"http://purl.obolibrary.org/obo/GO_0006338"},{"id":"T44","span":{"begin":288,"end":301},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sample-GO-BP

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T42","span":{"begin":72,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0003712"},{"id":"T43","span":{"begin":91,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0065007"},{"id":"T44","span":{"begin":254,"end":273},"obj":"http://purl.obolibrary.org/obo/GO_0006338"},{"id":"T45","span":{"begin":288,"end":308},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T46","span":{"begin":288,"end":301},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"487","span":{"begin":43,"end":46},"obj":"Gene"},{"id":"488","span":{"begin":47,"end":51},"obj":"Gene"},{"id":"489","span":{"begin":249,"end":253},"obj":"Gene"},{"id":"490","span":{"begin":282,"end":287},"obj":"Gene"},{"id":"491","span":{"begin":336,"end":340},"obj":"Gene"},{"id":"492","span":{"begin":341,"end":344},"obj":"Gene"},{"id":"493","span":{"begin":382,"end":401},"obj":"Disease"}],"attributes":[{"id":"A487","pred":"tao:has_database_id","subj":"487","obj":"Gene:1636"},{"id":"A488","pred":"tao:has_database_id","subj":"488","obj":"Gene:59272"},{"id":"A489","pred":"tao:has_database_id","subj":"489","obj":"Gene:6597"},{"id":"A490","pred":"tao:has_database_id","subj":"490","obj":"Gene:2305"},{"id":"A491","pred":"tao:has_database_id","subj":"491","obj":"Gene:59272"},{"id":"A492","pred":"tao:has_database_id","subj":"492","obj":"Gene:1636"},{"id":"A493","pred":"tao:has_database_id","subj":"493","obj":"MESH:D006332"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T107","span":{"begin":0,"end":119},"obj":"Sentence"},{"id":"T108","span":{"begin":120,"end":415},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins. Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart."}

PMC:7556165 / 16240-16655 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:7556165 / 16240-16655 JSON TXT