PMC:7556165 / 12039-12325 JSONTXT

{"project":"LitCovid-sample-MedDRA","denotations":[{"id":"T52","span":{"begin":120,"end":123},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"},{"id":"T53","span":{"begin":163,"end":168},"obj":"http://purl.bioontology.org/ontology/MEDDRA/10022891"}],"attributes":[{"id":"A52","pred":"meddra_id","subj":"T52","obj":"http://purl.bioontology.org/ontology/MEDDRA/10050289"},{"id":"A53","pred":"meddra_id","subj":"T53","obj":"http://purl.bioontology.org/ontology/MEDDRA/10038555"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}

{"project":"LitCovid-sample-CHEBI","denotations":[{"id":"T62","span":{"begin":124,"end":131},"obj":"Chemical"},{"id":"T63","span":{"begin":169,"end":180},"obj":"Chemical"}],"attributes":[{"id":"A62","pred":"chebi_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A63","pred":"chebi_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/CHEBI_48433"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}

{"project":"LitCovid-sample-PD-NCBITaxon","denotations":[{"id":"T41","span":{"begin":52,"end":57},"obj":"Species"}],"attributes":[{"id":"A41","pred":"ncbi_taxonomy_id","subj":"T41","obj":"NCBItxid:9606"}],"namespaces":[{"prefix":"NCBItxid","uri":"http://purl.bioontology.org/ontology/NCBITAXON/"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}

{"project":"LitCovid-sample-PD-UBERON","denotations":[{"id":"T18","span":{"begin":65,"end":71},"obj":"Body_part"},{"id":"T19","span":{"begin":163,"end":187},"obj":"Body_part"}],"attributes":[{"id":"A18","pred":"uberon_id","subj":"T18","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A19","pred":"uberon_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/UBERON_0018229"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}

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{"project":"LitCovid-sample-UniProt","denotations":[{"id":"T1560","span":{"begin":15,"end":19},"obj":"Protein"},{"id":"T1561","span":{"begin":120,"end":123},"obj":"Protein"},{"id":"T1586","span":{"begin":163,"end":168},"obj":"Protein"},{"id":"T1597","span":{"begin":169,"end":180},"obj":"Protein"}],"attributes":[{"id":"A1560","pred":"uniprot_id","subj":"T1560","obj":"https://www.uniprot.org/uniprot/Q9UFZ6"},{"id":"A1561","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q9GLN7"},{"id":"A1562","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q9GLN6"},{"id":"A1563","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q9EQM9"},{"id":"A1564","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q8CFN1"},{"id":"A1565","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q7TMC6"},{"id":"A1566","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q7M4L4"},{"id":"A1567","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q6GTS2"},{"id":"A1568","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q59GY8"},{"id":"A1569","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q53YX9"},{"id":"A1570","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q50JE5"},{"id":"A1571","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q10751"},{"id":"A1572","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q0GA41"},{"id":"A1573","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/P47820"},{"id":"A1574","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/P22968"},{"id":"A1575","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/P22967"},{"id":"A1576","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/P22966"},{"id":"A1577","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/P12822"},{"id":"A1578","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/P12821"},{"id":"A1579","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/P12820"},{"id":"A1580","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/P09470"},{"id":"A1581","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/O02852"},{"id":"A1582","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/E7EU16"},{"id":"A1583","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/B4DXI3"},{"id":"A1584","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/B0LPF0"},{"id":"A1585","pred":"uniprot_id","subj":"T1561","obj":"https://www.uniprot.org/uniprot/Q9VJV3"},{"id":"A1586","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/Q9TSZ1"},{"id":"A1587","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/Q6T5C2"},{"id":"A1588","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/Q6FI38"},{"id":"A1589","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/Q6DYE7"},{"id":"A1590","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/Q6DLW5"},{"id":"A1591","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/Q6DLS0"},{"id":"A1592","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/Q63497"},{"id":"A1593","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/P60016"},{"id":"A1594","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/P52115"},{"id":"A1595","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/P08424"},{"id":"A1596","pred":"uniprot_id","subj":"T1586","obj":"https://www.uniprot.org/uniprot/P00797"},{"id":"A1597","pred":"uniprot_id","subj":"T1597","obj":"https://www.uniprot.org/uniprot/Q10757"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}

{"project":"LitCovid-sample-PD-FMA","denotations":[{"id":"T53","span":{"begin":65,"end":71},"obj":"Body_part"},{"id":"T54","span":{"begin":124,"end":131},"obj":"Body_part"}],"attributes":[{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}

{"project":"LitCovid-sample-PD-GO-BP-0","denotations":[{"id":"T18","span":{"begin":20,"end":33},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}

{"project":"LitCovid-sample-GO-BP","denotations":[{"id":"T18","span":{"begin":20,"end":33},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}

{"project":"LitCovid-PubTator","denotations":[{"id":"374","span":{"begin":15,"end":19},"obj":"Gene"},{"id":"375","span":{"begin":120,"end":123},"obj":"Gene"},{"id":"376","span":{"begin":163,"end":168},"obj":"Gene"},{"id":"386","span":{"begin":52,"end":57},"obj":"Species"},{"id":"392","span":{"begin":2,"end":4},"obj":"Chemical"}],"attributes":[{"id":"A374","pred":"tao:has_database_id","subj":"374","obj":"Gene:59272"},{"id":"A375","pred":"tao:has_database_id","subj":"375","obj":"Gene:1636"},{"id":"A376","pred":"tao:has_database_id","subj":"376","obj":"Gene:5972"},{"id":"A386","pred":"tao:has_database_id","subj":"386","obj":"Tax:9606"},{"id":"A392","pred":"tao:has_database_id","subj":"392","obj":"MESH:D004958"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"t E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein. This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to m"}