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PMC:7556165 JSONTXT

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LitCovid-sample-MedDRA

Id Subject Object Predicate Lexical cue meddra_id
T1 78-107 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T2 131-134 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T3 202-205 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T4 1520-1523 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T5 1757-1771 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T6 2331-2345 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T7 2592-2621 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T8 2623-2626 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T9 2741-2754 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T10 2817-2820 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T11 2921-2924 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T12 3057-3060 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T13 3142-3145 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T14 3283-3296 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T15 3349-3352 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T16 3365-3379 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T17 3534-3537 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T18 4638-4652 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigations http://purl.bioontology.org/ontology/MEDDRA/10062026
T19 4655-4658 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T20 4691-4720 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Angiotensin-converting enzyme http://purl.bioontology.org/ontology/MEDDRA/10050289
T21 4722-4725 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T22 4873-4876 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T23 4897-4900 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T24 5050-5053 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T25 5170-5173 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T26 5255-5260 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes renin http://purl.bioontology.org/ontology/MEDDRA/10038555
T27 5418-5421 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T28 5547-5560 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T29 5611-5614 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T30 5708-5721 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T31 5734-5748 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T32 5834-5837 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T33 5956-5959 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T34 6078-6081 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T35 6357-6360 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T36 6516-6519 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T37 6728-6731 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T38 7056-7059 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T39 7329-7332 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T40 7360-7363 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T41 7884-7887 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T42 7974-7977 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T43 8428-8431 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T44 8513-8516 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T45 8643-8656 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T46 8660-8674 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T47 8740-8743 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T48 9711-9714 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T49 9922-9925 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T50 10143-10146 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T51 11464-11473 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes estradiol http://purl.bioontology.org/ontology/MEDDRA/10030227
T52 12159-12162 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T53 12202-12207 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes renin http://purl.bioontology.org/ontology/MEDDRA/10038555
T54 12432-12435 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T55 15856-15865 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Vitamin D http://purl.bioontology.org/ontology/MEDDRA/10050713
T56 15935-15944 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Vitamin D http://purl.bioontology.org/ontology/MEDDRA/10050713
T57 16158-16167 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes Vitamin D http://purl.bioontology.org/ontology/MEDDRA/10050713
T58 16283-16286 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T59 16581-16584 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T60 21404-21424 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes immunohistochemistry http://purl.bioontology.org/ontology/MEDDRA/10059656
T61 26039-26051 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T62 26118-26121 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T63 26170-26184 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T64 26478-26481 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T65 26851-26864 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T66 26943-26946 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T67 27382-27395 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin I http://purl.bioontology.org/ontology/MEDDRA/10002484
T68 27473-27476 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T69 29535-29538 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T70 30508-30511 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T71 30969-30972 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T72 30977-30991 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T73 32871-32874 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T74 32971-32974 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T75 32988-32991 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T76 33022-33025 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes ACE http://purl.bioontology.org/ontology/MEDDRA/10050289
T77 33180-33194 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes angiotensin II http://purl.bioontology.org/ontology/MEDDRA/10002491
T78 35436-35441 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes lipid http://purl.bioontology.org/ontology/MEDDRA/10024587
T79 45436-45446 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes microscopy http://purl.bioontology.org/ontology/MEDDRA/10069374
T80 45822-45834 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T81 45859-45864 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes X-ray http://purl.bioontology.org/ontology/MEDDRA/10048064
T82 46944-46956 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T83 47438-47450 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes investigated http://purl.bioontology.org/ontology/MEDDRA/10062026
T84 48846-48859 http://purl.bioontology.org/ontology/MEDDRA/10022891 denotes protein and S http://purl.bioontology.org/ontology/MEDDRA/10050417

LitCovid-sample-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T1 78-89 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T2 554-561 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T3 1181-1188 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T4 1539-1550 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T5 2213-2221 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T6 2592-2603 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T7 2679-2687 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T8 2692-2700 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T9 2741-2754 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T11 2759-2769 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T12 3283-3296 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T14 3668-3680 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T15 4691-4702 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T16 5012-5019 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T17 5261-5272 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T18 5273-5284 Chemical denotes aldosterone http://purl.obolibrary.org/obo/CHEBI_27584|http://purl.obolibrary.org/obo/CHEBI_30834
T20 5530-5538 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T21 5547-5560 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T23 5565-5575 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T24 5647-5658 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T25 5708-5721 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T27 5734-5748 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T30 5880-5890 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T31 5927-5934 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T32 6023-6027 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T34 6793-6810 Chemical denotes glutamate residue http://purl.obolibrary.org/obo/CHEBI_32484
T35 6824-6828 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T37 7290-7294 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T39 7346-7353 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T40 7404-7411 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T41 8312-8316 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T43 8341-8352 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T44 8565-8575 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T45 8643-8656 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T47 8660-8674 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T50 8695-8705 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T51 8761-8771 Chemical denotes lisinopril http://purl.obolibrary.org/obo/CHEBI_43755
T52 8776-8785 Chemical denotes captopril http://purl.obolibrary.org/obo/CHEBI_3380
T53 9170-9177 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T54 9868-9878 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T55 10195-10202 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T56 10225-10236 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T57 10455-10463 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365
T58 10896-10900 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T59 11464-11473 Chemical denotes estradiol http://purl.obolibrary.org/obo/CHEBI_23965
T60 11501-11508 Chemical denotes steroid http://purl.obolibrary.org/obo/CHEBI_35341
T61 11768-11772 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T62 12163-12170 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T63 12208-12219 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T64 13206-13213 Chemical denotes histone http://purl.obolibrary.org/obo/CHEBI_15358
T65 13389-13396 Chemical denotes histone http://purl.obolibrary.org/obo/CHEBI_15358
T66 13693-13701 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T67 13916-13919 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T68 14183-14190 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T69 14905-14912 Chemical denotes Histone http://purl.obolibrary.org/obo/CHEBI_15358
T70 15000-15003 Chemical denotes NAD http://purl.obolibrary.org/obo/CHEBI_13389|http://purl.obolibrary.org/obo/CHEBI_15846
T72 15249-15252 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T73 15278-15281 Chemical denotes CpG http://purl.obolibrary.org/obo/CHEBI_165823
T74 15856-15865 Chemical denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T75 15935-15944 Chemical denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T76 16158-16167 Chemical denotes Vitamin D http://purl.obolibrary.org/obo/CHEBI_89324
T77 16350-16358 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T78 16689-16693 Chemical denotes mRNA http://purl.obolibrary.org/obo/CHEBI_33699
T79 16957-16961 Chemical denotes mRNA http://purl.obolibrary.org/obo/CHEBI_33699
T80 18414-18421 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T81 18732-18739 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T82 20463-20470 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T83 21503-21506 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T84 21920-21927 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T85 22030-22033 Chemical denotes cat http://purl.obolibrary.org/obo/CHEBI_149681|http://purl.obolibrary.org/obo/CHEBI_32402
T87 22642-22649 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T88 23949-23952 Chemical denotes Lin http://purl.obolibrary.org/obo/CHEBI_32386
T89 24366-24370 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T90 24573-24580 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T91 26170-26184 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T94 26851-26864 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T96 27382-27395 Chemical denotes angiotensin I http://purl.obolibrary.org/obo/CHEBI_147350|http://purl.obolibrary.org/obo/CHEBI_2718
T98 27610-27620 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T99 28164-28176 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T100 28965-28976 Chemical denotes Angiotensin http://purl.obolibrary.org/obo/CHEBI_2719
T101 29168-29175 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T102 29176-29179 Chemical denotes Ala http://purl.obolibrary.org/obo/CHEBI_16977|http://purl.obolibrary.org/obo/CHEBI_46217
T104 29288-29295 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T105 29562-29572 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T106 29604-29614 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T107 29635-29645 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T108 29695-29705 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T109 29792-29801 Chemical denotes apelin-13 http://purl.obolibrary.org/obo/CHEBI_147395|http://purl.obolibrary.org/obo/CHEBI_80131
T111 29806-29817 Chemical denotes neurotensin http://purl.obolibrary.org/obo/CHEBI_147362|http://purl.obolibrary.org/obo/CHEBI_7542
T113 29819-29830 Chemical denotes dynorphin A http://purl.obolibrary.org/obo/CHEBI_4727
T114 29843-29850 Chemical denotes ghrelin http://purl.obolibrary.org/obo/CHEBI_75431
T115 29881-29889 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T116 30977-30991 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T119 32613-32623 Chemical denotes bradykinin http://purl.obolibrary.org/obo/CHEBI_3165
T120 32780-32785 Chemical denotes CXCL5 http://purl.obolibrary.org/obo/CHEBI_138180
T121 33180-33194 Chemical denotes angiotensin II http://purl.obolibrary.org/obo/CHEBI_2719|http://purl.obolibrary.org/obo/CHEBI_48432|http://purl.obolibrary.org/obo/CHEBI_58506
T124 33714-33717 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T125 33883-33895 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T126 34210-34222 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T127 35269-35276 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T128 35316-35324 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T129 35393-35401 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T130 35409-35417 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T131 35436-35441 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T132 35618-35625 Chemical denotes glycans http://purl.obolibrary.org/obo/CHEBI_18154
T133 35641-35646 Chemical denotes crown http://purl.obolibrary.org/obo/CHEBI_37409
T134 35738-35750 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T135 35923-35930 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T136 36150-36157 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T137 36540-36547 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T138 36582-36589 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T139 37327-37334 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T140 37430-37437 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T141 37515-37522 Chemical denotes glycine http://purl.obolibrary.org/obo/CHEBI_15428|http://purl.obolibrary.org/obo/CHEBI_29947|http://purl.obolibrary.org/obo/CHEBI_57305
T144 37530-37537 Chemical denotes alanine http://purl.obolibrary.org/obo/CHEBI_16449
T145 37947-37955 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T146 39156-39163 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T147 39838-39845 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T148 41268-41275 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T149 41922-41929 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T150 42256-42263 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T151 42383-42390 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T152 43039-43051 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T153 44486-44489 Chemical denotes RNA http://purl.obolibrary.org/obo/CHEBI_33697
T154 45150-45157 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T155 45719-45727 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T156 46203-46212 Chemical denotes disulfide http://purl.obolibrary.org/obo/CHEBI_48343
T157 46397-46402 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T158 47173-47180 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T159 48025-48032 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T160 48601-48608 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T161 48846-48853 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T162 50205-50212 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T163 50436-50443 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T164 51415-51426 Chemical denotes Pro-Pro-Ala http://purl.obolibrary.org/obo/CHEBI_162578
T165 51453-51464 Chemical denotes Gly-Val-Glu http://purl.obolibrary.org/obo/CHEBI_164159
T166 51465-51468 Chemical denotes Gly http://purl.obolibrary.org/obo/CHEBI_15428
T167 51695-51698 Chemical denotes Ile http://purl.obolibrary.org/obo/CHEBI_17191|http://purl.obolibrary.org/obo/CHEBI_30009
T169 52869-52876 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T170 57683-57694 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T171 60140-60148 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T172 61792-61797 Chemical denotes IP-10 http://purl.obolibrary.org/obo/CHEBI_138157
T173 61799-61802 Chemical denotes MCP http://purl.obolibrary.org/obo/CHEBI_132592|http://purl.obolibrary.org/obo/CHEBI_50099
T175 63163-63170 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T176 63210-63217 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T177 63237-63244 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T178 63285-63292 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T179 65674-65681 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T180 66200-66207 Chemical denotes phorbol http://purl.obolibrary.org/obo/CHEBI_8116
T181 66208-66217 Chemical denotes myristate http://purl.obolibrary.org/obo/CHEBI_30807
T182 66218-66225 Chemical denotes acetate http://purl.obolibrary.org/obo/CHEBI_30089|http://purl.obolibrary.org/obo/CHEBI_47622
T184 66262-66273 Chemical denotes polypeptide http://purl.obolibrary.org/obo/CHEBI_15841
T185 66515-66530 Chemical denotes hydroxamic acid http://purl.obolibrary.org/obo/CHEBI_24650
T186 67491-67500 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T187 67839-67848 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T188 67941-67950 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T189 68157-68166 Chemical denotes vitamin D http://purl.obolibrary.org/obo/CHEBI_27300
T190 69122-69129 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T191 69456-69464 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T192 69720-69758 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine http://purl.obolibrary.org/obo/CHEBI_145998
T193 70067-70074 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T194 71031-71042 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T195 71243-71250 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T196 71457-71464 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T197 72299-72312 Chemical denotes nanoparticles http://purl.obolibrary.org/obo/CHEBI_50803
T198 72768-72775 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T199 72907-72914 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T200 72927-72938 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T201 72955-72962 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T202 73082-73093 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T203 73150-73160 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T204 73302-73309 Chemical denotes glucose http://purl.obolibrary.org/obo/CHEBI_4167|http://purl.obolibrary.org/obo/CHEBI_17234
T206 73392-73399 Chemical denotes insulin http://purl.obolibrary.org/obo/CHEBI_145810
T207 73729-73737 Chemical denotes peptides http://purl.obolibrary.org/obo/CHEBI_16670
T208 76787-76800 Chemical denotes macromolecule http://purl.obolibrary.org/obo/CHEBI_33839
T209 77651-77663 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T210 77747-77754 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080

LitCovid-sample-PD-NCBITaxon

Id Subject Object Predicate Lexical cue ncbi_taxonomy_id
T1 19-29 Species denotes SARS-CoV-2 NCBItxid:2697049
T2 19-23 Species denotes SARS NCBItxid:694009
T3 812-845 Species denotes severe acute respiratory syndrome NCBItxid:694009
T4 847-851 Species denotes SARS NCBItxid:694009
T5 889-898 Species denotes SARS-CoV2 NCBItxid:2697049
T6 889-893 Species denotes SARS NCBItxid:694009
T7 919-943 Species denotes COronaVIrus Disease 2019 NCBItxid:2697049
T8 945-953 Species denotes COVID-19 NCBItxid:2697049
T9 979-987 Species denotes COVID-19 NCBItxid:2697049
T10 1075-1084 Species denotes SARS-CoV2 NCBItxid:2697049
T11 1075-1079 Species denotes SARS NCBItxid:694009
T12 1131-1140 Species denotes SARS-CoV2 NCBItxid:2697049
T13 1131-1135 Species denotes SARS NCBItxid:694009
T14 1407-1416 Species denotes SARS-CoV2 NCBItxid:2697049
T15 1407-1411 Species denotes SARS NCBItxid:694009
T16 1626-1636 Species denotes SARS-CoV-2 NCBItxid:2697049
T17 1626-1630 Species denotes SARS NCBItxid:694009
T18 2017-2025 Species denotes COVID-19 NCBItxid:2697049
T19 2507-2515 Species denotes COVID-19 NCBItxid:2697049
T20 3636-3644 Species denotes SARS-CoV NCBItxid:694009
T21 3636-3640 Species denotes SARS NCBItxid:694009
T22 3771-3781 Species denotes SARS-CoV-2 NCBItxid:2697049
T23 3771-3775 Species denotes SARS NCBItxid:694009
T24 3823-3831 Species denotes COVID-19 NCBItxid:2697049
T25 4011-4019 Species denotes COVID-19 NCBItxid:2697049
T26 4290-4300 Species denotes SARS-CoV-2 NCBItxid:2697049
T27 4290-4294 Species denotes SARS NCBItxid:694009
T28 4685-4690 Species denotes Human NCBItxid:9606
T29 6148-6153 Species denotes human NCBItxid:9606
T30 6351-6356 Species denotes human NCBItxid:9606
T31 6576-6583 Species denotes insects NCBItxid:6960|NCBItxid:50557
T33 6620-6625 Species denotes human NCBItxid:9606
T34 7045-7050 Species denotes human NCBItxid:9606
T35 8808-8812 Species denotes Rice NCBItxid:4530
T36 11351-11356 Species denotes human NCBItxid:9606
T37 11873-11881 Species denotes COVID-19 NCBItxid:2697049
T38 11916-11926 Species denotes SARS-CoV-2 NCBItxid:2697049
T39 11916-11920 Species denotes SARS NCBItxid:694009
T40 11969-11977 Species denotes COVID-19 NCBItxid:2697049
T41 12091-12096 Species denotes human NCBItxid:9606
T42 14286-14291 Species denotes human NCBItxid:9606
T43 14585-14590 Species denotes human NCBItxid:9606
T44 16171-16179 Species denotes COVID-19 NCBItxid:2697049
T45 16227-16237 Species denotes Sars-CoV-2 NCBItxid:2697049
T46 18056-18066 Species denotes Sars-CoV-2 NCBItxid:2697049
T47 19643-19648 Species denotes human NCBItxid:9606
T48 19954-19960 Species denotes rodent NCBItxid:9989
T49 20253-20258 Species denotes human NCBItxid:9606
T50 20525-20530 Species denotes human NCBItxid:9606
T51 21098-21106 Species denotes primates NCBItxid:9443
T52 21219-21226 Species denotes trachea NCBItxid:988164
T53 21294-21299 Species denotes human NCBItxid:9606
T54 21626-21636 Species denotes SARS-CoV-2 NCBItxid:2697049
T55 21626-21630 Species denotes SARS NCBItxid:694009
T56 21710-21718 Species denotes COVID-19 NCBItxid:2697049
T57 22018-22023 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T59 22025-22028 Species denotes rat NCBItxid:10116|NCBItxid:10114
T61 22030-22033 Species denotes cat NCBItxid:9685
T62 22035-22041 Species denotes ferret NCBItxid:9669
T63 22043-22049 Species denotes monkey NCBItxid:9527|NCBItxid:9479
T65 22054-22059 Species denotes human NCBItxid:9606
T66 22203-22210 Species denotes rodents NCBItxid:9989
T67 23040-23047 Species denotes rodents NCBItxid:9989
T68 23243-23248 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T70 23852-23863 Species denotes hippocampus NCBItxid:72046
T71 24407-24412 Species denotes human NCBItxid:9606
T72 24595-24600 Species denotes human NCBItxid:9606
T73 24813-24819 Species denotes rodent NCBItxid:9989
T74 24957-24962 Species denotes human NCBItxid:9606
T75 25032-25037 Species denotes human NCBItxid:9606
T76 25448-25453 Species denotes human NCBItxid:9606
T77 26287-26292 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T79 28725-28730 Species denotes human NCBItxid:9606
T80 29498-29504 Species denotes sepsis NCBItxid:137507
T81 31268-31274 Species denotes sepsis NCBItxid:137507
T82 31307-31314 Species denotes anthrax NCBItxid:1392
T159 38543-38551 Species denotes MERS CoV NCBItxid:1335626
T83 31350-31364 Species denotes H5N1 avian flu NCBItxid:102793
T84 31369-31373 Species denotes SARS NCBItxid:694009
T85 31418-31422 Species denotes mice NCBItxid:10095|NCBItxid:10088
T87 31514-31520 Species denotes sepsis NCBItxid:137507
T88 32677-32682 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T90 32864-32869 Species denotes human NCBItxid:9606
T91 33240-33263 Species denotes avian influenza viruses NCBItxid:11309
T92 33264-33268 Species denotes H5N1 NCBItxid:102793
T93 33273-33277 Species denotes H7N9 NCBItxid:333278
T94 33395-33403 Species denotes COVID-19 NCBItxid:2697049
T95 33506-33539 Species denotes severe acute respiratory syndrome NCBItxid:694009
T96 33541-33545 Species denotes SARS NCBItxid:694009
T97 33714-33723 Species denotes RNA virus NCBItxid:2559587
T98 33770-33778 Species denotes SARS-CoV NCBItxid:694009
T99 33770-33774 Species denotes SARS NCBItxid:694009
T100 34112-34120 Species denotes SARS-CoV NCBItxid:694009
T101 34112-34116 Species denotes SARS NCBItxid:694009
T102 34150-34156 Species denotes Monkey NCBItxid:9527|NCBItxid:9479
T104 34312-34320 Species denotes SARS-CoV NCBItxid:694009
T105 34312-34316 Species denotes SARS NCBItxid:694009
T106 34332-34336 Species denotes SARS NCBItxid:694009
T107 34466-34471 Species denotes human NCBItxid:9606
T108 34658-34668 Species denotes SARS-CoV-2 NCBItxid:2697049
T109 34658-34662 Species denotes SARS NCBItxid:694009
T110 34702-34710 Species denotes SARS-CoV NCBItxid:694009
T111 34702-34706 Species denotes SARS NCBItxid:694009
T112 34758-34766 Species denotes COVID-19 NCBItxid:2697049
T113 34768-34792 Species denotes COronaVIrus Disease 2019 NCBItxid:2697049
T114 34843-34853 Species denotes SARS-CoV-2 NCBItxid:2697049
T115 34843-34847 Species denotes SARS NCBItxid:694009
T116 35000-35008 Species denotes COVID-19 NCBItxid:2697049
T117 35055-35065 Species denotes SARS-CoV-2 NCBItxid:2697049
T118 35055-35059 Species denotes SARS NCBItxid:694009
T119 35910-35920 Species denotes SARS-CoV-2 NCBItxid:2697049
T120 35910-35914 Species denotes SARS NCBItxid:694009
T121 35994-36008 Species denotes human SARS-CoV NCBItxid:694009
T122 36000-36004 Species denotes SARS NCBItxid:694009
T123 36073-36083 Species denotes SARS-CoV-2 NCBItxid:2697049
T124 36073-36077 Species denotes SARS NCBItxid:694009
T125 36127-36135 Species denotes SARS-CoV NCBItxid:694009
T126 36127-36131 Species denotes SARS NCBItxid:694009
T127 36265-36273 Species denotes SARS-CoV NCBItxid:694009
T128 36265-36269 Species denotes SARS NCBItxid:694009
T129 36279-36289 Species denotes SARS-CoV-2 NCBItxid:2697049
T130 36279-36283 Species denotes SARS NCBItxid:694009
T131 36366-36374 Species denotes SARS-CoV NCBItxid:694009
T132 36366-36370 Species denotes SARS NCBItxid:694009
T133 36378-36388 Species denotes SARS-CoV-2 NCBItxid:2697049
T134 36378-36382 Species denotes SARS NCBItxid:694009
T135 36389-36396 Species denotes viruses NCBItxid:10239
T136 36551-36559 Species denotes SARS-CoV NCBItxid:694009
T137 36551-36555 Species denotes SARS NCBItxid:694009
T138 36564-36574 Species denotes SARS-CoV-2 NCBItxid:2697049
T139 36564-36568 Species denotes SARS NCBItxid:694009
T140 37089-37097 Species denotes SARS-CoV NCBItxid:694009
T141 37089-37093 Species denotes SARS NCBItxid:694009
T142 37113-37123 Species denotes SARS-CoV-2 NCBItxid:2697049
T143 37113-37117 Species denotes SARS NCBItxid:694009
T144 37959-37967 Species denotes SARS-CoV NCBItxid:694009
T145 37959-37963 Species denotes SARS NCBItxid:694009
T146 37972-37982 Species denotes SARS-CoV-2 NCBItxid:2697049
T147 37972-37976 Species denotes SARS NCBItxid:694009
T148 38043-38050 Species denotes viruses NCBItxid:10239
T149 38194-38199 Species denotes human NCBItxid:9606
T150 38201-38204 Species denotes bat NCBItxid:9397
T151 38217-38220 Species denotes pig NCBItxid:9823
T152 38230-38235 Species denotes mouse NCBItxid:10090|NCBItxid:10088
T154 38394-38404 Species denotes SARS-CoV-2 NCBItxid:2697049
T155 38394-38398 Species denotes SARS NCBItxid:694009
T156 38408-38416 Species denotes SARS-CoV NCBItxid:694009
T157 38408-38412 Species denotes SARS NCBItxid:694009
T158 38484-38489 Species denotes human NCBItxid:9606
T160 38556-38565 Species denotes HCoV-229E NCBItxid:11137
T161 38596-38607 Species denotes pseudovirus NCBItxid:186672
T162 38705-38715 Species denotes SARS-CoV-2 NCBItxid:2697049
T163 38705-38709 Species denotes SARS NCBItxid:694009
T164 38766-38773 Species denotes viruses NCBItxid:10239
T165 38922-38930 Species denotes SARS-CoV NCBItxid:694009
T166 38922-38926 Species denotes SARS NCBItxid:694009
T167 38935-38945 Species denotes SARS-CoV-2 NCBItxid:2697049
T168 38935-38939 Species denotes SARS NCBItxid:694009
T169 39006-39014 Species denotes SARS-CoV NCBItxid:694009
T170 39006-39010 Species denotes SARS NCBItxid:694009
T171 39019-39029 Species denotes SARS-CoV-2 NCBItxid:2697049
T172 39019-39023 Species denotes SARS NCBItxid:694009
T173 42267-42277 Species denotes SARS-CoV-2 NCBItxid:2697049
T174 42267-42271 Species denotes SARS NCBItxid:694009
T175 42648-42658 Species denotes SARS-CoV-2 NCBItxid:2697049
T176 42648-42652 Species denotes SARS NCBItxid:694009
T177 42722-42732 Species denotes SARS-CoV-2 NCBItxid:2697049
T178 42722-42726 Species denotes SARS NCBItxid:694009
T179 42756-42764 Species denotes SARS-CoV NCBItxid:694009
T180 42756-42760 Species denotes SARS NCBItxid:694009
T181 42782-42799 Species denotes bat coronaviruses NCBItxid:1508220
T182 43086-43099 Species denotes pseudoviruses NCBItxid:186672
T183 43108-43118 Species denotes SARS-CoV-2 NCBItxid:2697049
T184 43108-43112 Species denotes SARS NCBItxid:694009
T185 43230-43243 Species denotes pseudoviruses NCBItxid:186672
T186 43252-43260 Species denotes SARS-CoV NCBItxid:694009
T187 43252-43256 Species denotes SARS NCBItxid:694009
T188 43286-43296 Species denotes SARS-COV-2 NCBItxid:2697049
T189 43286-43290 Species denotes SARS NCBItxid:694009
T190 43738-43748 Species denotes SARS-CoV-2 NCBItxid:2697049
T191 43738-43742 Species denotes SARS NCBItxid:694009
T192 43791-43799 Species denotes COVID-19 NCBItxid:2697049
T193 44127-44134 Species denotes viruses NCBItxid:10239
T194 44217-44224 Species denotes viruses NCBItxid:10239
T195 44276-44283 Species denotes viruses NCBItxid:10239
T196 44502-44509 Species denotes viruses NCBItxid:10239
T197 44826-44833 Species denotes viruses NCBItxid:10239
T198 44914-44924 Species denotes SARS-CoV-2 NCBItxid:2697049
T199 44914-44918 Species denotes SARS NCBItxid:694009
T200 44958-44968 Species denotes SARS-CoV-2 NCBItxid:2697049
T201 44958-44962 Species denotes SARS NCBItxid:694009
T202 44973-44981 Species denotes SARS-CoV NCBItxid:694009
T203 44973-44977 Species denotes SARS NCBItxid:694009
T204 45049-45059 Species denotes SARS-CoV-2 NCBItxid:2697049
T205 45049-45053 Species denotes SARS NCBItxid:694009
T206 45090-45098 Species denotes SARS-CoV NCBItxid:694009
T207 45090-45094 Species denotes SARS NCBItxid:694009
T208 45100-45108 Species denotes SARS-CoV NCBItxid:694009
T209 45100-45104 Species denotes SARS NCBItxid:694009
T210 45226-45236 Species denotes SARS-CoV-2 NCBItxid:2697049
T211 45226-45230 Species denotes SARS NCBItxid:694009
T212 45283-45291 Species denotes SARS-CoV NCBItxid:694009
T213 45283-45287 Species denotes SARS NCBItxid:694009
T214 45399-45409 Species denotes SARS-CoV-2 NCBItxid:2697049
T215 45399-45403 Species denotes SARS NCBItxid:694009
T216 45455-45465 Species denotes SARS-CoV-2 NCBItxid:2697049
T217 45455-45459 Species denotes SARS NCBItxid:694009
T218 45636-45640 Species denotes MERS NCBItxid:1335626
T219 45786-45796 Species denotes SARS-CoV-2 NCBItxid:2697049
T220 45786-45790 Species denotes SARS NCBItxid:694009
T221 45893-45903 Species denotes SARS-CoV-2 NCBItxid:2697049
T222 45893-45897 Species denotes SARS NCBItxid:694009
T223 46323-46333 Species denotes SARS-COV-2 NCBItxid:2697049
T224 46323-46327 Species denotes SARS NCBItxid:694009
T225 46338-46346 Species denotes SARS-CoV NCBItxid:694009
T226 46338-46342 Species denotes SARS NCBItxid:694009
T227 46556-46566 Species denotes SARS-CoV-2 NCBItxid:2697049
T228 46556-46560 Species denotes SARS NCBItxid:694009
T229 46710-46720 Species denotes SARS-CoV-2 NCBItxid:2697049
T230 46710-46714 Species denotes SARS NCBItxid:694009
T231 46976-46986 Species denotes SARS-CoV-2 NCBItxid:2697049
T232 46976-46980 Species denotes SARS NCBItxid:694009
T233 47073-47083 Species denotes SARS-CoV-2 NCBItxid:2697049
T234 47073-47077 Species denotes SARS NCBItxid:694009
T235 47544-47554 Species denotes SARS-CoV-2 NCBItxid:2697049
T236 47544-47548 Species denotes SARS NCBItxid:694009
T237 47613-47621 Species denotes SARS-CoV NCBItxid:694009
T238 47613-47617 Species denotes SARS NCBItxid:694009
T239 47793-47803 Species denotes SARS-CoV-2 NCBItxid:2697049
T240 47793-47797 Species denotes SARS NCBItxid:694009
T241 47841-47851 Species denotes SARS-CoV-2 NCBItxid:2697049
T242 47841-47845 Species denotes SARS NCBItxid:694009
T243 47875-47883 Species denotes SARS-CoV NCBItxid:694009
T244 47875-47879 Species denotes SARS NCBItxid:694009
T245 48012-48022 Species denotes SARS-CoV-2 NCBItxid:2697049
T246 48012-48016 Species denotes SARS NCBItxid:694009
T247 48072-48076 Species denotes SARS NCBItxid:694009
T248 48139-48149 Species denotes SARS-CoV-2 NCBItxid:2697049
T249 48139-48143 Species denotes SARS NCBItxid:694009
T250 48208-48216 Species denotes SARS-CoV NCBItxid:694009
T251 48208-48212 Species denotes SARS NCBItxid:694009
T252 48386-48396 Species denotes SARS-CoV-2 NCBItxid:2697049
T253 48386-48390 Species denotes SARS NCBItxid:694009
T254 48401-48409 Species denotes SARS-CoV NCBItxid:694009
T255 48401-48405 Species denotes SARS NCBItxid:694009
T256 48445-48455 Species denotes SARS-CoV-2 NCBItxid:2697049
T257 48445-48449 Species denotes SARS NCBItxid:694009
T258 48758-48768 Species denotes SARS-CoV-2 NCBItxid:2697049
T259 48758-48762 Species denotes SARS NCBItxid:694009
T260 48825-48835 Species denotes SARS-CoV-2 NCBItxid:2697049
T261 48825-48829 Species denotes SARS NCBItxid:694009
T262 48923-48929 Species denotes SARS-2 NCBItxid:2697049
T263 48923-48927 Species denotes SARS NCBItxid:694009
T264 48963-48969 Species denotes SARS-2 NCBItxid:2697049
T265 48963-48967 Species denotes SARS NCBItxid:694009
T266 49001-49007 Species denotes SARS-2 NCBItxid:2697049
T267 49001-49005 Species denotes SARS NCBItxid:694009
T268 49051-49057 Species denotes SARS-2 NCBItxid:2697049
T269 49051-49055 Species denotes SARS NCBItxid:694009
T270 49104-49110 Species denotes SARS-2 NCBItxid:2697049
T271 49104-49108 Species denotes SARS NCBItxid:694009
T272 49154-49160 Species denotes SARS-2 NCBItxid:2697049
T273 49154-49158 Species denotes SARS NCBItxid:694009
T274 49202-49208 Species denotes SARS-2 NCBItxid:2697049
T275 49202-49206 Species denotes SARS NCBItxid:694009
T276 49269-49275 Species denotes SARS-2 NCBItxid:2697049
T277 49269-49273 Species denotes SARS NCBItxid:694009
T278 49512-49520 Species denotes SARS-CoV NCBItxid:694009
T279 49512-49516 Species denotes SARS NCBItxid:694009
T280 49636-49644 Species denotes SARS-CoV NCBItxid:694009
T281 49636-49640 Species denotes SARS NCBItxid:694009
T282 49815-49825 Species denotes SARS-CoV-2 NCBItxid:2697049
T283 49815-49819 Species denotes SARS NCBItxid:694009
T284 49891-49901 Species denotes SARS-CoV-2 NCBItxid:2697049
T285 49891-49895 Species denotes SARS NCBItxid:694009
T286 50565-50573 Species denotes SARS-CoV NCBItxid:694009
T287 50565-50569 Species denotes SARS NCBItxid:694009
T288 50587-50597 Species denotes SARS-CoV-2 NCBItxid:2697049
T289 50587-50591 Species denotes SARS NCBItxid:694009
T290 50662-50672 Species denotes SARS-CoV-2 NCBItxid:2697049
T291 50662-50666 Species denotes SARS NCBItxid:694009
T292 50732-50740 Species denotes SARS-CoV NCBItxid:694009
T293 50732-50736 Species denotes SARS NCBItxid:694009
T294 51333-51343 Species denotes SARS-CoV-2 NCBItxid:2697049
T295 51333-51337 Species denotes SARS NCBItxid:694009
T296 51348-51356 Species denotes SARS-CoV NCBItxid:694009
T297 51348-51352 Species denotes SARS NCBItxid:694009
T298 51385-51393 Species denotes SARS-CoV NCBItxid:694009
T299 51385-51389 Species denotes SARS NCBItxid:694009
T300 51472-51482 Species denotes SARS-CoV-2 NCBItxid:2697049
T301 51472-51476 Species denotes SARS NCBItxid:694009
T302 51664-51674 Species denotes SARS-CoV-2 NCBItxid:2697049
T303 51664-51668 Species denotes SARS NCBItxid:694009
T304 51702-51706 Species denotes SARS NCBItxid:694009
T305 52041-52051 Species denotes SARS-CoV-2 NCBItxid:2697049
T306 52041-52045 Species denotes SARS NCBItxid:694009
T307 52068-52072 Species denotes SARS NCBItxid:694009
T308 52177-52187 Species denotes SARS-CoV-2 NCBItxid:2697049
T309 52177-52181 Species denotes SARS NCBItxid:694009
T310 52758-52765 Species denotes mammals NCBItxid:40674
T311 52790-52794 Species denotes cats NCBItxid:9685
T312 52799-52803 Species denotes dogs NCBItxid:9615
T313 52856-52866 Species denotes SARS-CoV-2 NCBItxid:2697049
T314 52856-52860 Species denotes SARS NCBItxid:694009
T315 52891-52899 Species denotes COVID-19 NCBItxid:2697049
T316 53039-53044 Species denotes human NCBItxid:9606
T317 53050-53059 Species denotes hCoV-NL63 NCBItxid:277944
T318 53189-53193 Species denotes SARS NCBItxid:694009
T319 53206-53216 Species denotes SARS-CoV-2 NCBItxid:2697049
T320 53206-53210 Species denotes SARS NCBItxid:694009
T321 53262-53271 Species denotes hCoV-NL63 NCBItxid:277944
T322 53294-53302 Species denotes SARS-CoV NCBItxid:694009
T323 53294-53298 Species denotes SARS NCBItxid:694009
T324 53445-53455 Species denotes SARS-CoV-2 NCBItxid:2697049
T325 53445-53449 Species denotes SARS NCBItxid:694009
T326 53647-53653 Species denotes humans NCBItxid:9605
T327 53709-53712 Species denotes bat NCBItxid:9397
T328 53762-53765 Species denotes bat NCBItxid:9397
T329 53880-53890 Species denotes SARS-CoV-2 NCBItxid:2697049
T330 53880-53884 Species denotes SARS NCBItxid:694009
T331 53947-53950 Species denotes bat NCBItxid:9397
T332 54069-54077 Species denotes COVID-19 NCBItxid:2697049
T333 55046-55054 Species denotes COVID-19 NCBItxid:2697049
T334 55888-55896 Species denotes COVID-19 NCBItxid:2697049
T335 55983-55993 Species denotes SARS-CoV-2 NCBItxid:2697049
T336 55983-55987 Species denotes SARS NCBItxid:694009
T337 56598-56606 Species denotes SARS-CoV NCBItxid:694009
T338 56598-56602 Species denotes SARS NCBItxid:694009
T339 56690-56700 Species denotes SARS-CoV-2 NCBItxid:2697049
T340 56690-56694 Species denotes SARS NCBItxid:694009
T341 56786-56796 Species denotes SARS-CoV-2 NCBItxid:2697049
T342 56786-56790 Species denotes SARS NCBItxid:694009
T343 58281-58291 Species denotes SARS-CoV-2 NCBItxid:2697049
T344 58281-58285 Species denotes SARS NCBItxid:694009
T345 58525-58535 Species denotes SARS-CoV-2 NCBItxid:2697049
T346 58525-58529 Species denotes SARS NCBItxid:694009
T347 59195-59203 Species denotes COVID-19 NCBItxid:2697049
T348 59596-59604 Species denotes COVID-19 NCBItxid:2697049
T349 59714-59722 Species denotes COVID-19 NCBItxid:2697049
T350 59937-59947 Species denotes SARS-CoV-2 NCBItxid:2697049
T351 59937-59941 Species denotes SARS NCBItxid:694009
T352 59961-59966 Species denotes human NCBItxid:9606
T353 60095-60100 Species denotes human NCBItxid:9606
T354 60247-60255 Species denotes COVID-19 NCBItxid:2697049
T355 60356-60366 Species denotes SARS-CoV-2 NCBItxid:2697049
T356 60356-60360 Species denotes SARS NCBItxid:694009
T357 60417-60424 Species denotes COVID19 NCBItxid:2697049
T358 60758-60766 Species denotes COVID-19 NCBItxid:2697049
T359 61221-61229 Species denotes COVID-19 NCBItxid:2697049
T360 61601-61609 Species denotes COVID-19 NCBItxid:2697049
T361 63668-63678 Species denotes SARS-CoV-2 NCBItxid:2697049
T362 63668-63672 Species denotes SARS NCBItxid:694009
T363 63687-63697 Species denotes SARS-CoV-2 NCBItxid:2697049
T364 63687-63691 Species denotes SARS NCBItxid:694009
T365 63905-63913 Species denotes COVID-19 NCBItxid:2697049
T366 64110-64118 Species denotes COVID-19 NCBItxid:2697049
T367 64302-64312 Species denotes SARS-CoV-2 NCBItxid:2697049
T368 64302-64306 Species denotes SARS NCBItxid:694009
T369 66111-66116 Species denotes human NCBItxid:9606
T370 66160-66165 Species denotes human NCBItxid:9606
T371 67297-67307 Species denotes SARS-CoV-2 NCBItxid:2697049
T372 67297-67301 Species denotes SARS NCBItxid:694009
T373 67465-67475 Species denotes SARS-CoV-2 NCBItxid:2697049
T374 67465-67469 Species denotes SARS NCBItxid:694009
T375 67668-67676 Species denotes COVID-19 NCBItxid:2697049
T376 67853-67863 Species denotes SARS-CoV-2 NCBItxid:2697049
T377 67853-67857 Species denotes SARS NCBItxid:694009
T378 67896-67906 Species denotes SARS-CoV-2 NCBItxid:2697049
T379 67896-67900 Species denotes SARS NCBItxid:694009
T380 68269-68279 Species denotes SARS-CoV-2 NCBItxid:2697049
T381 68269-68273 Species denotes SARS NCBItxid:694009
T382 68468-68476 Species denotes COVID-19 NCBItxid:2697049
T383 68528-68538 Species denotes SARS-CoV-2 NCBItxid:2697049
T384 68528-68532 Species denotes SARS NCBItxid:694009
T385 69007-69012 Species denotes human NCBItxid:9606
T386 69633-69641 Species denotes SARS-CoV NCBItxid:694009
T387 69633-69637 Species denotes SARS NCBItxid:694009
T388 69855-69863 Species denotes SARS-CoV NCBItxid:694009
T389 69855-69859 Species denotes SARS NCBItxid:694009
T390 70158-70162 Species denotes SARS NCBItxid:694009
T391 70313-70329 Species denotes SARS coronavirus NCBItxid:694009
T392 70313-70317 Species denotes SARS NCBItxid:694009
T393 70708-70718 Species denotes SARS-CoV-2 NCBItxid:2697049
T394 70708-70712 Species denotes SARS NCBItxid:694009
T395 71025-71030 Species denotes human NCBItxid:9606
T396 71089-71097 Species denotes COVID-19 NCBItxid:2697049
T397 71135-71140 Species denotes human NCBItxid:9606
T398 71395-71403 Species denotes COVID-19 NCBItxid:2697049
T399 71775-71785 Species denotes SARS-CoV-2 NCBItxid:2697049
T400 71775-71779 Species denotes SARS NCBItxid:694009
T401 71811-71816 Species denotes human NCBItxid:9606
T402 71844-71849 Species denotes human NCBItxid:9606
T403 72005-72015 Species denotes SARS-CoV-2 NCBItxid:2697049
T404 72005-72009 Species denotes SARS NCBItxid:694009
T405 72112-72122 Species denotes SARS-CoV-2 NCBItxid:2697049
T406 72112-72116 Species denotes SARS NCBItxid:694009
T407 73184-73198 Species denotes gut microbiome NCBItxid:749906
T408 74270-74275 Species denotes human NCBItxid:9606
T409 74290-74294 Species denotes mice NCBItxid:10095|NCBItxid:10088
T411 74752-74760 Species denotes COVID-19 NCBItxid:2697049
T412 77350-77358 Species denotes COVID-19 NCBItxid:2697049
T413 77457-77461 Species denotes SARS NCBItxid:694009
T414 77470-77479 Species denotes SARS-Cov2 NCBItxid:2697049
T415 77470-77474 Species denotes SARS NCBItxid:694009
T416 77480-77487 Species denotes viruses NCBItxid:10239
T417 77907-77915 Species denotes COVID-19 NCBItxid:2697049
T418 78152-78160 Species denotes COVID-19 NCBItxid:2697049

LitCovid-sample-sentences

Id Subject Object Predicate Lexical cue
T1 0-30 Sentence denotes ACE2 in the Era of SARS-CoV-2:
T2 31-67 Sentence denotes Controversies and Novel Perspectives
T3 69-77 Sentence denotes Abstract
T4 78-206 Sentence denotes Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE.
T5 207-295 Sentence denotes ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation.
T6 296-418 Sentence denotes ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs.
T7 419-548 Sentence denotes Also, ACE2 expression is regulated post-translationally by glycosylation, phosphorylation, and shedding from the plasma membrane.
T8 549-666 Sentence denotes ACE2 protein is ubiquitous across mammalian tissues, prominently in the cardiovascular system, kidney, and intestine.
T9 667-955 Sentence denotes ACE2 expression in the respiratory tract is of particular interest, in light of the discovery that ACE2 serves as the initial cellular target of severe acute respiratory syndrome (SARS)-coronaviruses, including the recent SARS-CoV2, responsible of the COronaVIrus Disease 2019 (COVID-19).
T10 956-1102 Sentence denotes Since the onset of the COVID-19 pandemic, an intense effort has been made to elucidate the biochemical determinants of SARS-CoV2-ACE2 interaction.
T11 1103-1377 Sentence denotes It has been determined that SARS-CoV2 engages with ACE2 through its spike (S) protein, which consists of two subunits: S1, that mediates binding to the host receptor; S2, that induces fusion of the viral envelope with the host cell membrane and delivery of the viral genome.
T12 1378-1647 Sentence denotes Owing to the role of ACE2 in SARS-CoV2 pathogenicity, it has been speculated that medical conditions, i.e., hypertension, and/or drugs, i.e., ACE inhibitors and angiotensin receptor blockers, known to influence ACE2 density could alter the fate of SARS-CoV-2 infection.
T13 1648-1792 Sentence denotes The debate is still open and will only be solved when results of properly designed experimental and clinical investigations will be made public.
T14 1793-1919 Sentence denotes An interesting observation is, however that, upon infection, ACE2 activity is reduced either by downregulation or by shedding.
T15 1920-2032 Sentence denotes These events might precipitate the so-called “cytokine storm” that characterizes the most severe COVID-19 forms.
T16 2033-2142 Sentence denotes As evidence accumulates, ACE2 appears a druggable target in the attempt to limit virus entry and replication.
T17 2143-2346 Sentence denotes Strategies aimed at blocking ACE2 with antibodies, small molecules or peptides, or at neutralizing the virus by competitive binding with exogenously administered ACE2, are currently under investigations.
T18 2347-2577 Sentence denotes In this review, we will present an overview of the state-of-the-art knowledge on ACE2 biochemistry and pathophysiology, outlining open issues in the context of COVID-19 disease and potential experimental and clinical developments.
T19 2579-2591 Sentence denotes Introduction
T20 2592-2770 Sentence denotes Angiotensin-converting enzyme (ACE) has an important role in the metabolism of several peptides and proteins, including chemical messengers, such as angiotensin I and bradykinin.
T21 2771-3044 Sentence denotes The importance assumed by research focused on ACE biochemistry, physiology and pharmacology is closely linked to the clinical effectiveness showed by ACE inhibitors in the treatment of cardiovascular disease, particularly arterial hypertension and congestive heart failure.
T22 3045-3125 Sentence denotes At present, ACE inhibitors are among the most widely prescribed drugs worldwide.
T23 3126-3197 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 3198-3297 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 3298-3364 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 3365-3564 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 3565-3737 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 3738-3952 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.
T29 3953-4194 Sentence denotes Hypertension has been suggested to have a major impact on COVID-19 susceptibility and prognosis, therefore the elusive link between hypertension, anti-hypertensive drugs, and ACE2 expression has soon become the object of a major controversy.
T30 4195-4374 Sentence denotes On the other hand, treatments able to interfere with ACE2 expression, or ACE2 availability for SARS-CoV-2 binding, have been identified as a novel goal of pharmaceutical research.
T31 4375-4482 Sentence denotes The purpose of the present review is to summarize the available knowledge on ACE2 biochemistry and biology.
T32 4483-4653 Sentence denotes We have also tried to point out some crucial open questions, which should be addressed to provide a better background for future experimental and clinical investigations.
T33 4655-4684 Sentence denotes ACE System and ACE2 Discovery
T34 4685-4908 Sentence denotes Human Angiotensin-converting enzyme (ACE) belongs to the M2 gluzincin family of metalloproteinases and (Ehlers and Riordan, 1989; Masuyer et al., 2014) exists in two forms, namely somatic ACE (sACE) and germinal ACE (tACE).
T35 4909-5131 Sentence denotes Both are derived from the same gene, controlled by alternative promotors. sACE is an integral membrane protein, which can be also cleaved by ACE secretases to produce a circulating form of the enzyme (Natesh et al., 2003).
T36 5132-5368 Sentence denotes sACE, hereafter referred to simply as ACE, has been extensively studied, because of its crucial role in the homeostasis of renin-angiotensin-aldosterone (RAAS) system and in cardiovascular diseases (Takimoto-Ohnishi and Murakami, 2019).
T37 5369-5602 Sentence denotes The two extracellular domains N and C domains of ACE (Wei et al., 1991; Jaspard et al., 1993; Natesh et al., 2003; Riordan, 2003) can both hydrolase two crucial peptides, namely angiotensin I and bradykinin, with the same efficiency.
T38 5603-5823 Sentence denotes Indeed, ACE carries out the cleavage of two amino acids (dipeptidase action) from the C-terminal part of angiotensin I to generate angiotensin II, which exerts a potent vasopressor, proliferative, and profibrotic effect.
T39 5824-5935 Sentence denotes Moreover, ACE mediates the cleavage and inactivation of bradykinin, which is a vasodilator hypotensive peptide.
T40 5936-6063 Sentence denotes The pivotal role of ACE in the RAAS system allows a refined blood pressure control and salt homeostasis (Sayer and Bhat, 2014).
T41 6064-6252 Sentence denotes Following the ACE discovery in mid-1950s, despite intense research in the field, no human homologs of the enzyme have been found for more than 50 years (Isaac et al., 1998; Riordan, 2003).
T42 6253-6404 Sentence denotes It was only in 2000 that two independent research groups identified, almost simultaneously, a new human ACE-like enzyme, with two different approaches.
T43 6405-6584 Sentence denotes Tipnis et al. (2000) searched for new metalloproteases in an expressed sequence tag (EST) database, finding an ACE homolog (ACEH) with a single domain, similar to that of insects.
T44 6585-6648 Sentence denotes Subsequently they cloned it from a human lymphoma cDNA library.
T45 6649-6837 Sentence denotes Interestingly ACEH showed high homology (40% identity and 60% similarity) with ACE, particularly around the HEXXH sequence and highly conserved glutamate residue, involved in zinc binding.
T46 6838-6930 Sentence denotes Moreover, they demonstrated the presence of seven glycosylation sites (Tipnis et al., 2000).
T47 6931-7251 Sentence denotes In the same year, Donoghue et al. (2000b) were searching for new genes involved in heart failure and identified a human cDNA ACE homolog, named ACE2, among 19,000 5’end sequences by RACE (rapid amplification of cDNA ends) in the heart ventricle cDNA library, obtained from a woman with idiopathic dilated cardiomyopathy.
T48 7252-7354 Sentence denotes ACE2 showed a transmembrane domain, a zinc catalytic domain 42% identical to ACE and a signal peptide.
T49 7355-7412 Sentence denotes Like ACE, ACE2 seemed to be an ectoenzyme type I protein.
T50 7413-7581 Sentence denotes The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b).
T51 7582-7721 Sentence denotes In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.
T52 7723-7728 Sentence denotes ACE2:
T53 7729-7785 Sentence denotes Structure, Expression, Tissue Distribution, and Function
T54 7787-7804 Sentence denotes Structure of ACE2
T55 7805-7926 Sentence denotes ACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17.
T56 7927-7984 Sentence denotes The 18 exons of ACE2 are remarkably similar to ACE exons.
T57 7985-8274 Sentence denotes The ACE2 gene depicts a large polymorphism and several novel polymorphisms of ACE2, with specific geographical distribution, have been described and associated with susceptibility to hypertension and cardiovascular disease (Burrell et al., 2013; Patel et al., 2014; Pinheiro et al., 2019).
T58 8275-8395 Sentence denotes The ACE2 gene codifies for a typical zinc-metallopeptidase of 805 amino acids (120 kDa), with a unique catalytic domain.
T59 8396-8506 Sentence denotes Despite the high resemblance of ACE and ACE2, considerable differences exist in their substrates and products.
T60 8507-8596 Sentence denotes While ACE acts as dipeptidase, ACE2 removes only a single amino acid from its substrates.
T61 8597-8848 Sentence denotes Therefore, ACE2 is not active in transforming angiotensin I to angiotensin II and in inactivating bradykinin; moreover, ACE2 is insensitive to ACE inhibitors, like lisinopril and captopril (Tipnis et al., 2000; Rice et al., 2004; Turner et al., 2004).
T62 8849-8946 Sentence denotes These differences depend on variances in the three-dimensional structure (3D) of the two enzymes.
T63 8947-9055 Sentence denotes Comparative homology modeling and crystallography contributed to shed light on ACE2 3D structure (Figure 1).
T64 9056-9208 Sentence denotes Prabakaran et al. (2004) clarified the major characteristic of ACE2, which is a deep channel on the summit of the protein, hosting the catalytic domain.
T65 9209-9357 Sentence denotes Specific loops, like the long loop N210-Q221 that is exclusive of ACE2, α helices and a portion of β-sheet are located around the catalytic channel.
T66 9358-9518 Sentence denotes The negative charge of the channel and the presence of distinct hydrophobic regions contribute to the specificity of the binding site (Prabakaran et al., 2004).
T67 9519-9781 Sentence denotes The determination of the crystal structure of the extracellular domain to 2.2-3-A resolution from Towler et al. (2004) and the model from Guy et al. (2003) showed that the catalytic domain of ACE and ACE2 are very conserved and have similar mechanisms of action.
T68 9782-10053 Sentence denotes The main difference stems from the smaller ACE2 pocket, thereby lodging only a single amino acid: the crucial substitution of the Gln281 in ACE binding pocket with Arg273 in ACE2 is likely to be responsible for the steric conflict (Guy et al., 2003; Towler et al., 2004).
T69 10054-10290 Sentence denotes Another surprise of the ACE2 structure was its C-terminal domain, which—differently from ACE—revealed high homology with collectrin, a renal protein, which is involved in amino acids trafficking through the membrane (Yang et al., 2017).
T70 10291-10327 Sentence denotes FIGURE 1 Crystal structure of ACE2.
T71 10328-10443 Sentence denotes The peptidase domain (PD) is in green, whereas the collectrin homology domain is enclosed in the light cyan square.
T72 10444-10589 Sentence denotes The active zinc ion is showed enclosed in a red circle, whereas the glycosylation moieties are showed as cyan cubes and denoted by dashed arrows.
T73 10590-10683 Sentence denotes The structures have been drawn from PDB 1R42 (Towler et al., 2004) by Mol on the PDB website.
T74 10685-10765 Sentence denotes Transcriptional, Post-transcriptional, and Post-translational Regulation of ACE2
T75 10766-11049 Sentence denotes The location of the ACE2 gene on the X chromosome questions whether one of the two ACE2 is silenced in females, to balance female/male expression dosage (X chromosome inactivation or XCI), or otherwise belongs to the class of “escape genes” which are transcribed on both chromosomes.
T76 11050-11238 Sentence denotes Interestingly, a wide survey of XCI in several individuals and tissues showed that ACE2 is a heterogeneous escape gene, because it has a tissue-dependent sex bias (Tukiainen et al., 2017).
T77 11239-11391 Sentence denotes A growing number of recent findings point to an important role of epigenetic mechanisms associated with several human diseases (Surguchov et al., 2017).
T78 11392-11566 Sentence denotes In this context, several authors highlighted the regulatory role of 17β-estradiol (E2), a primary female sex steroid, in the expression of ACE2 in a tissue-dependent fashion.
T79 11567-11715 Sentence denotes Liu et al. (2010) and Stelzig et al. (2020) found out that E2 downregulates ACE2 in kidney and differentiated airway epithelial cells, respectively.
T80 11716-11998 Sentence denotes The latter result is particularly important, as the male-bias of ACE2 expression in the lung could account for the alleged higher susceptibility of males to COVID-19 symptoms following ACE2-dependent SARS-CoV-2 infection (section Links Between ACE2 and COVID-19) (Jin et al., 2020).
T81 11999-12171 Sentence denotes Yet, Bukowska et al. (2017) observed that E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein.
T82 12172-12383 Sentence denotes This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to myocardial stress and contributes to antiarhythmic effects.
T83 12384-12530 Sentence denotes The upregulation of ACE2 (and downregulation of ACE) was clearly linked to binding of E2 to Estrogen Receptor alpha (ERα) (Bukowska et al., 2017).
T84 12531-12771 Sentence denotes The E2-ERα complex might migrate to the nucleus to bind to estrogen response elements, although the actual mechanism is still obscure and should likely involve other co-factors to take into account the observed tissue bias of E2 regulation.
T85 12772-13021 Sentence denotes Nonetheless, it was demonstrated that the Estrogen Related Receptor alpha (ERRα), which likewise ERα recognizes the estrogen response element in target genes, binds to ACE2 promoter to repress transcription (Tremblay et al., 2010; Lee et al., 2012).
T86 13022-13124 Sentence denotes Hopefully, future studies will shed more light on the intriguing role of estrogens in ACE2 regulation.
T87 13125-13287 Sentence denotes A recent analysis of public genomic and transcriptomic data outlined the role of histone methylation, a classical epigenetic mark, to regulate ACE2 transcription.
T88 13288-13449 Sentence denotes Indeed, Li Y. et al. (2020) showed that transcription of ACE2 was significantly upregulated when the histone mutant H3K27M was overexpressed to inhibit H3K27me3.
T89 13450-13532 Sentence denotes Conversely, overexpression of mutant H3K4/9/36M did not change ACE2 transcription.
T90 13533-13688 Sentence denotes Trimethylation of K27 on H3 is catalyzed by the polycomb groups (PcG), a group of conserved transcriptional gene repressors (Schuettengruber et al., 2017).
T91 13689-13751 Sentence denotes PcG proteins assemble into two major complexes: PRC1 and PRC2.
T92 13752-13876 Sentence denotes The simplest model of PcG activity involves trimethylation of H3 by PRC2 at target gene promoters (Blackledge et al., 2015).
T93 13877-14125 Sentence denotes These epigenetic marks recruit PRC1 on DNA, which in turn acts as E3-ligase and ubiquitinates nearby H2A histones (Storti et al., 2019), triggering silencing of gene transcription by local and reversible compaction of chromatin (Illingworth, 2019).
T94 14126-14191 Sentence denotes The catalytic subunit of PRC2 is constituted by the EZH2 protein.
T95 14192-14359 Sentence denotes In agreement with the inverse correlation between ACE2 level and H3K27me3, ACE2 expression in human ESCs was upregulated following EZH2 knock-out (Li Y. et al., 2020).
T96 14360-14423 Sentence denotes On the other side, recovery of EZH2 restored basal ACE2 levels.
T97 14424-14617 Sentence denotes Chromatin immunoprecipitation sequencing (ChIP-seq) showed that EZH2 depletion induced H3K27me3 decrease, with concomitant H3K27ac increase, at ACE2 promoter in human ESCs (Li Y. et al., 2020).
T98 14618-14904 Sentence denotes The role of H3 methylation and acetylation in the epigenetic regulation of ACE2 was also hypothesized by Pinto et al., who demonstrated that co-morbidities such as hypertension, diabetes, and chronic obstructive lung disease increase ACE2 transcription in the lung (Pinto et al., 2020).
T99 14905-14986 Sentence denotes Histone methylation does not appear to exhaust the epigenetic regulation of ACE2.
T100 14987-15135 Sentence denotes Notably, the NAD+-dependent deacetylase SIRT1 binds to ACE2 promoter favoring its transcription during cellular energy stress (Clarke et al., 2014).
T101 15136-15216 Sentence denotes Two recent unrefereed preprints highlighted other epigenetic mechanisms at play.
T102 15217-15421 Sentence denotes Corley et al.1 pointed out that DNA methylation across three CpG islands in the ACE2 promoter was lower in lung epithelial cells compared to other cell types, suggesting high transcription in lung tissue.
T103 15422-15624 Sentence denotes These findings are in excellent agreement with the reported inverse correlation between ACE2 transcription and promoter methylation in tumors, which will be discussed in section ACE2 and Other Diseases.
T104 15625-15807 Sentence denotes This correlation is also supported by the observation that in children ACE2 is normally hypermethylated and poorly expressed either in the lung and in other organs (Pruimboom, 2020).
T105 15808-16029 Sentence denotes Glinsky (2020) addressed the epigenetic role of Vitamin D on ACE2 expression, showing by gene set enrichment analysis that the Vitamin D receptor (VDR) should be involved in a set of regulatory pathways conveying on ACE2.
T106 16030-16239 Sentence denotes More specifically, VDR activation would downregulate ACE2, thus affording a potential reason for the alleged beneficial role of Vitamin D in COVID-19 (section ACE2 and the Inflammatory Response to Sars-CoV-2).
T107 16240-16359 Sentence denotes Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins.
T108 16360-16655 Sentence denotes Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart.
T109 16656-16700 Sentence denotes Further regulation occurs at the mRNA level.
T110 16701-16826 Sentence denotes From putative microRNA-binding sites identified in vitro, Lambert et al. (2014) demonstrated that miR-421 downregulates ACE2.
T111 16827-16974 Sentence denotes According to the hypothesized mechanism, miR-421 modulates ACE2 expression by hampering translation rather than by degradation of mRNA transcripts.
T112 16975-17190 Sentence denotes Beside undergoing post-translational modifications by glycosylation and phosphorylation, ACE2 is also post-translationally regulated by shedding from cell membrane through the action of the metalloproteinase ADAM17.
T113 17191-17361 Sentence denotes The proteolysis of ACE2 releases a soluble, enzymatically active form which corresponds to the ACE2 ectodomain (Jia et al., 2009; Xiao et al., 2014; Conrad et al., 2016).
T114 17362-17479 Sentence denotes The function, if any, of soluble ACE2 is still obscure, but the shedding mechanism is under strict molecular control.
T115 17480-17642 Sentence denotes Lambert et al. (2008) highlighted that calmodulin associates with ACE2 to prevent its shedding, while calmodulin inhibitors increase the cellular release of ACE2.
T116 17643-17692 Sentence denotes Patel identified a positive feedback in the RAAS:
T117 17693-17803 Sentence denotes Ang II activates ADAM17, thereby increasing the release of ACE2, its negative regulator (Patel et al., 2016b).
T118 17804-17935 Sentence denotes It is worth noting that high levels of plasma-soluble ACE2 have been associated with myocardial dysfunction (Epelman et al., 2009).
T119 17936-18067 Sentence denotes The potential pathophysiological role of ADAM17 is further discussed in paragraph ACE2 and the Inflammatory Response to Sars-CoV-2.
T120 18068-18188 Sentence denotes Figure 2 summarizes the known transcriptional, post-transcriptional, and post translational regulation pathways of ACE2.
T121 18189-18290 Sentence denotes FIGURE 2 Regulation pathways of transcription, translation, and post-translational shedding of ACE2.
T122 18291-18323 Sentence denotes Red text: non-molecular factors.
T123 18324-18354 Sentence denotes Black text: molecular factors.
T124 18356-18383 Sentence denotes Tissue Distribution of ACE2
T125 18384-18524 Sentence denotes Detectable quantities of ACE2 protein have been found almost ubiquitously in tissues across mammalian species, using immunostaining methods.
T126 18525-18742 Sentence denotes ACE2 is predominantly located in the cardiovascular system and kidney, where it probably plays a role in the maintenance of hydro electrolyte homeostasis (section “Mechanism of Viral Entry Mediated by the S Protein”).
T127 18743-18961 Sentence denotes In fact, ACE2 is pervasively expressed throughout the vasculature, at the level of the arteries and veins, mainly in smooth muscle cells of the media and in the endothelium (Hamming et al., 2004; Burrell et al., 2005).
T128 18962-19052 Sentence denotes Such signal from vessels also delivers part of the expression detected in specific organs.
T129 19053-19391 Sentence denotes Indeed, ACE2 is evident in: coronary vessels and myocardial capillaries (Wiener et al., 2007; Garabelli et al., 2008); lung microvascular endothelial cells (Wiener et al., 2007; Chen et al., 2013); kidney interlobular arteries (Lely et al., 2004); endothelial and smooth muscle cells in the brain (Hamming et al., 2004; Kar et al., 2010).
T130 19392-19569 Sentence denotes Notably, the mesangium and glomerular endothelium in the kidney, and the endothelial lining of the sinusoids in the liver are allegedly negative for ACE2 (Hamming et al., 2004).
T131 19570-19757 Sentence denotes On the contrary, ACE2 is virtually absent from the lymphatic system, and human hemato-lymphoid organs (i.e., spleen, lymph nodes, and bone marrow) (Hamming et al., 2004; Li et al., 2007).
T132 19758-19905 Sentence denotes In blood cells, it has been observed in platelets and macrophages, but not in B and T lymphocytes (Hamming et al., 2004; Fraga-Silva et al., 2011).
T133 19906-20249 Sentence denotes Expression of ACE2 was originally identified in rodent heart (Donoghue et al., 2000a), where it was observed to occur in both atrium an ventricle (Gembardt et al., 2005), and, cellularly, in cardiomyocytes and in specialized cells of the sinoatrial node (Burrell et al., 2005; Garabelli et al., 2008; Ferreira et al., 2011; Wang et al., 2017).
T134 20250-20442 Sentence denotes In human heart, ACE2 has been found in the stromal area in spongiosa layer in aortic valves (Peltonen et al., 2011), where it is expressed in myofibroblasts and fibroblasts (Guy et al., 2008).
T135 20443-20730 Sentence denotes High levels of ACE2 protein expression have been detected in mammalian, including human, kidney (Gembardt et al., 2005; Koka et al., 2008; Reich et al., 2008; Giani et al., 2012; Mitani et al., 2014; Grobe et al., 2015; Shi et al., 2015; Larouche-Lebel et al., 2019; Alawi et al., 2020).
T136 20731-21069 Sentence denotes Strong signals were reported in the brush border of the proximal tubular cells, whereas weak to moderate signals could be found in the glomeruli, Henle’s loop, distal tubules, and collecting duct (Hamming et al., 2004; Lely et al., 2004; Kamilic et al., 2010; Giani et al., 2012; Bae et al., 2015; Cao et al., 2017; Errarte et al., 2017).
T137 21070-21264 Sentence denotes In the respiratory tract of primates, positive labeling for ACE2 has been reported at multiple sites, from the nasal and oral mucosa, to the larynx, trachea, bronchi and lung (Liu et al., 2011).
T138 21265-21550 Sentence denotes Whether ACE2 is expressed in human nasal and oral epithelium remains unclear, as contradictory results have been reported by studies using immunohistochemistry (Hamming et al., 2004; Bertram et al., 2012), in face of positive single-cell RNA sequencing findings (Sungnak et al., 2020).
T139 21551-21721 Sentence denotes This point is of great interest to understand the role of those tissues in SARS-CoV-2 initial infection, spread and clearance (section “Links Between ACE2 and COVID-19”).
T140 21722-21879 Sentence denotes In the upper respiratory tract ACE2 is expressed in the epithelial lining and lamina propria, in some muscle cells and in the salivary gland duct epithelium.
T141 21880-22174 Sentence denotes In the lung, an intense signal for ACE2 protein has been consistently observed in type I and II pneumocytes in several species, including mouse, rat, cat, ferret, monkey and human (Wiener et al., 2007; van den Brand et al., 2008; Liu et al., 2011; Wong et al., 2012; Chen et al., 2013; Zhang B.
T142 22175-22192 Sentence denotes N. et al., 2019).
T143 22193-22357 Sentence denotes Data from rodents suggest an age- and gender-dependent pattern of expression, with a more rapid decline with age in males as compared to females (Xie et al., 2006).
T144 22358-22636 Sentence denotes Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020).
T145 22637-22826 Sentence denotes ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon.
T146 22827-23036 Sentence denotes Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004).
T147 23037-23203 Sentence denotes In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010).
T148 23204-23294 Sentence denotes ACE2 distribution is widespread in the mouse brain, from the telencephalon to the medulla.
T149 23295-23701 Sentence denotes As expected, ACE2 is found in brain areas involved in the regulation of cardiovascular function and fluid balance, such as the vascular organ of lamina terminalis, subfornical organ, magnocellular neurons in the hypothalamic paraventricular nucleus, area postrema, nucleus of the solitary tract, dorsal motor nucleus of the vagus, nucleus ambiguous, and rostral ventrolateral medulla (Doobay et al., 2007).
T150 23702-23985 Sentence denotes However, significant expression had also been reported in brain areas not engaged in the classical functions of the RAAS, namely the piriform cortex, hippocampus, caudate putamen, hypoglossal nucleus and primary motor cortex (Doobay et al., 2007; Lin et al., 2008; Liu et al., 2014).
T151 23986-24123 Sentence denotes ACE2 immunostaining was identified in neurons as well as astrocytes (Gallagher et al., 2006; Doobay et al., 2007; Yamazato et al., 2007).
T152 24124-24294 Sentence denotes Furthermore, ACE2 has been documented in the retina, predominantly in the inner nuclear layer but also in photoreceptors (Tikellis et al., 2004; Senanayake et al., 2007).
T153 24295-24403 Sentence denotes With regard to the endocrine system, ACE2 expression was found in both male and female reproductive systems.
T154 24404-24541 Sentence denotes In human testis, ACE2 was localized to the Leydig and Sertoli cells, and might be involved in testicular function (Douglas et al., 2004).
T155 24542-24809 Sentence denotes At present, no data about ACE2 protein expression is human ovaries is available, although evidence of expression in stroma, theca, and granulosa cells has been reported in other species (Tonellotto dos Santos et al., 2012; Barreta et al., 2015; Pereira et al., 2015).
T156 24810-24923 Sentence denotes In rodent bone, ACE2 is expressed in osteoblasts and osteoclasts, as well as in epithelial cells and fibroblasts.
T157 24924-25028 Sentence denotes However, a similar expression in human samples still awaits clarification (Queiroz-Junior et al., 2019).
T158 25029-25154 Sentence denotes In human skin, ACE2 was present in the basal cell layer of the epidermis extending to the basal cell layer of hair follicles.
T159 25155-25236 Sentence denotes Smooth muscle cells surrounding the sebaceous glands were also positive for ACE2.
T160 25237-25301 Sentence denotes Weak cytoplasmic staining was observed in sebaceous gland cells.
T161 25302-25386 Sentence denotes A strong granular staining pattern for ACE2 was seen in cells of the eccrine glands.
T162 25387-25567 Sentence denotes Positive staining for ACE2 was also noted in the membrane of human fat cells in various organs, including the epicardial adipose tissue (Hamming et al., 2004; Patel et al., 2016a).
T163 25568-25678 Sentence denotes Globally, ACE2 is chiefly bound to cell membranes, while negligible levels can be detected in the circulation.
T164 25680-25722 Sentence denotes ACE2, the RAAS System and Cardioprotection
T165 25723-25987 Sentence denotes After the initial discovery of ACE2 in the heart and kidney, it is now clear that it is widely distributed in tissues (section Tissue Distribution of ACE2), where it exerts many physiological effects and may be involved in pathophysiological events (Turner, 2015).
T166 25988-26194 Sentence denotes The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II).
T167 26195-26421 Sentence denotes The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinning of the left ventricular wall.
T168 26422-26553 Sentence denotes Interestingly, in this knockout model disruption of the ACE pathway could rescue the myocardial phenotype (Crackower et al., 2002).
T169 26554-26689 Sentence denotes In another study, a selective ACE2 knockout model showed high blood pressure, worsened by the infusion of Ang-II (Gurley et al., 2006).
T170 26690-26828 Sentence denotes As a matter of fact, ACE2 displays its carboxypeptidase activity converting Ang-II to a heptapeptide, namely Ang1–7 (Turner et al., 2004).
T171 26829-27037 Sentence denotes ACE2 can also convert angiotensin I (Ang-I) to the non apeptide Ang1–9, which is in turn converted into Ang1–7 by ACE, competing with Ang-I and thus further decreasing Ang-II (Arendse et al., 2019; Figure 3).
T172 27038-27243 Sentence denotes Ang1–7 has been demonstrated to bind to the MasR receptor, which was initially regarded as an orphan receptor, since the use of a MasR antagonist caused inhibition of Ang1–7 effects (Alenina et al., 2008).
T173 27244-27477 Sentence denotes FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE.
T174 27478-27581 Sentence denotes ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs).
T175 27582-27720 Sentence denotes ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm.
T176 27721-28072 Sentence denotes In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016).
T177 28073-28320 Sentence denotes Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008).
T178 28321-28508 Sentence denotes In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI).
T179 28509-28843 Sentence denotes In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005).
T180 28844-28909 Sentence denotes Additional players contribute to ACE2-mediated cardio-protection.
T181 28910-29104 Sentence denotes Another substrate of ACE2 carboxypeptidase activity is Angiotensin A (Ang-A), identified in 2008, which has a similar, although less potent, vasopressor effect as AngII (Jankowski et al., 2007).
T182 29105-29248 Sentence denotes The product of the enzymatic reaction catalyzed by ACE2 is the peptide Ala-Ang (1–7) also known as alamandine (Lautner et al., 2013; Figure 3).
T183 29249-29384 Sentence denotes Alamandine receptor is a Mas-related G-protein coupled receptor, known as MrgD, which is expressed in cardiomyocytes and blood vessels.
T184 29385-29527 Sentence denotes MrgD knockout animals develop a severe cardiopathy and alamandine showed a cardioprotective effect in a model of sepsis (Santos et al., 2019).
T185 29528-29758 Sentence denotes Unlike ACE, ACE2 is not active on bradykinin, but it can degrade the active bradykinin metabolite des-Arg9 bradykinin (DABK), blocking the signaling pathway of the B1 bradykinin receptor (Vickers et al., 2002; Sodhi et al., 2018).
T186 29759-29866 Sentence denotes Other substrates of ACE2 include apelin-13/17, neurotensin, dynorphin A (1–13), and ghrelin (Turner, 2015).
T187 29867-30069 Sentence denotes Interestingly peptides of apelin family have been demonstrated to upregulate ACE2 expression in physiological condition and more actively during heart failure in in vivo experiments (Sato et al., 2013).
T188 30070-30334 Sentence denotes ACE2 in turn is able to regulate apelin bioavailability, establishing a negative feedback loop, and the crosstalk between RAAS, ACE2 and Apelin system might play a significant role in the pathophysiology of hypertension (Kalea and Batlle, 2010; Chen et al., 2015).
T189 30335-30689 Sentence denotes On the whole these findings suggest that ACE2 might exert antihypertensive and/or cardioprotective effects by different mechanisms, namely: (i) limiting the availability of ACE substrates, (ii) degrading Ang-II, (iii) activating the Ang1-7/MasR and/or Alamandine/MrgD pathways, (iv) interfering with other substrates, such as DABK and apelins (Figure 3).
T190 30691-30711 Sentence denotes ACE2 and Lung Injury
T191 30712-30846 Sentence denotes ACE2 is highly expressed in type I and II alveolar epithelial cells and in pulmonary small vessels (either endothelial cells or VSMC).
T192 30847-31153 Sentence denotes The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010).
T193 31154-31375 Sentence denotes ARDS is an overly aggressive form of ALI and it is the final mechanism of lung injury in many diseases, including sepsis, acid aspiration, pancreatitis, anthrax and virus infections (Spanish flu, H5N1 avian flu and SARS).
T194 31376-31521 Sentence denotes Imai et al. developed three ACE2 knockout mice models with severe ARDS induced by acid aspiration, endotoxin administration or peritoneal sepsis.
T195 31522-31743 Sentence denotes They showed that ARDS was accompanied by increased vessel permeability, lung oedema, and infiltration of inflammation cells, with consequent impairment of respiratory function (Imai et al., 2005, 2007; Kuba et al., 2006).
T196 31744-31888 Sentence denotes The phenotype was dramatically improved and rescued either administering ACE2 recombinant analogs or AT1Ra inhibitors (Imai et al., 2005, 2008).
T197 31889-32139 Sentence denotes ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012).
T198 32140-32338 Sentence denotes An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013).
T199 32339-32561 Sentence denotes The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015).
T200 32562-32640 Sentence denotes ACE2 might also modulate lung inflammation via the bradykinin-DABK/BKB1R axis.
T201 32641-32860 Sentence denotes In fact, decreased ACE2 function in mouse lungs caused increased activity of the DABK axis and triggered a proinflammatory cytokine storm (CXCL5, MIP2, KC, and TNF-α), leading to pulmonary collapse (Sodhi et al., 2018).
T202 32861-32924 Sentence denotes In human, ACE/ACE2 imbalance may be related to genetic factors.
T203 32925-33149 Sentence denotes In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002).
T204 33150-33370 Sentence denotes More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014).
T205 33372-33403 Sentence denotes Links Between ACE2 and COVID-19
T206 33404-33652 Sentence denotes A “second life” for ACE2 was discovered in 2003, when a novel respiratory infective disease, known as severe acute respiratory syndrome (SARS), appeared in China and spread all over Asia and Canada, with a lethality rate of 10% (Rota et al., 2003).
T207 33653-33802 Sentence denotes The responsible pathogen was identified in a positive strand RNA virus belonging to the coronavirus family and named SARS-CoV (Ksiazek et al., 2003).
T208 33803-34023 Sentence denotes The virus genome was sequenced and this allowed the identification of the spike glycoprotein (S), whose N-terminal portion, or S1-domain, was found to mediate the high affinity binding to host cells (Marra et al., 2003).
T209 34024-34311 Sentence denotes The group of Farzan et al. succeeded in identifying the cell receptor: they showed that SARS-CoV efficiently infected African Monkey kidney cell line Vero E6 and co-immunoprecipitated a glycoprotein responsible for virus binding and entry, which was identified as ACE2 (Li et al., 2003).
T210 34312-34418 Sentence denotes SARS-CoV caused the SARS epidemic in 2002–2003, with over 8,000 infections and a fatality rate around 10%.
T211 34419-34615 Sentence denotes In late 2019, another coronavirus emerged as a human pathogen in the city of Wuhan in China, producing symptoms such as fever, severe respiratory impairment, and pneumonia (Petersen et al., 2020).
T212 34616-34794 Sentence denotes This new coronavirus has been denominated SARS-CoV-2 for its genetic resemblance with SARS-CoV (∼80%), and its related disease has been named COVID-19 (COronaVIrus Disease 2019).
T213 34795-34955 Sentence denotes Owing to its high reproduction number R0 (2–3), SARS-CoV-2 has rapidly diffused in several countries and is currently posing a significant global health threat.
T214 34956-35029 Sentence denotes On March 11, 2020, the WHO has declared the COVID-19 outbreak a pandemic.
T215 35030-35224 Sentence denotes The early discovery that SARS-CoV-2 also engages ACE2 as entry door for cell infection has prompted an intense research effort to elucidate the biochemical determinants of CoV-ACE2 interactions.
T216 35226-35276 Sentence denotes Mechanism of Viral Entry Mediated by the S Protein
T217 35277-35402 Sentence denotes A coronavirus contains four structural proteins, namely spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins.
T218 35403-35529 Sentence denotes These proteins assemble around a lipid bilayer to provide the shell enclosing the viral genome (Figure 4A; Tang et al., 2020).
T219 35530-35721 Sentence denotes Homotrimers of S protrude from the viral surface, and are densely decorated by N-linked glycans, creating the “crown” (“Corona” in Latin) that christens this virus group (Walls et al., 2016).
T220 35722-35876 Sentence denotes S is a ∼180 kDa glycoprotein anchored in the viral membrane, which plays the most important roles in viral attachment, fusion and entry (Ou et al., 2020).
T221 35877-36027 Sentence denotes Sequence analysis has shown that SARS-CoV-2 S protein shares 76% of the primary sequence with the corresponding S of human SARS-CoV (Ou et al., 2020).
T222 36028-36158 Sentence denotes Accordingly, it has been early proposed that SARS-CoV-2 utilizes a similar cell entry mechanism as SARS-CoV, pivoted on S protein.
T223 36159-36229 Sentence denotes This hypothesis has been confirmed from an experimental point of view.
T224 36230-36442 Sentence denotes By using pseudotyped virus bearing SARS-CoV S or SARS-CoV-2 S, it was shown that a large panel of cell lines allows comparable entry of SARS-CoV or SARS-CoV-2 viruses (Hoffmann et al., 2020b; Walls et al., 2020).
T225 36443-36575 Sentence denotes FIGURE 4 (A) Structure of a Coronavirus. (B) Functional motifs in the sequence of the S “spike” protein of SARS-CoV and SARS-CoV-2.
T226 36576-36857 Sentence denotes The S protein consists of ∼1300 aminoacids and it is composed by a N-terminal “S1”subunit (∼700 aa) and a C-terminal “S2”subunit (∼600 aa); binding to the host receptor is mediated by S1, whereas S2 induces fusion of the viral envelope with cellular membranes (Walls et al., 2017).
T227 36858-36984 Sentence denotes S1 and S2 can be further subdivided in functional segments with different roles in viral entry (Figure 4B; Tang et al., 2020).
T228 36985-37085 Sentence denotes The S1 subunit contains two subdomains, the N-terminal domain (NTD) and the C-terminal domain (CTD).
T229 37086-37289 Sentence denotes In SARS-CoV (Li, 2015) and SARS-CoV-2 (Wang et al., 2020) CTD encloses the receptor-binding domain (RBD), and the RBD section that directly contacts the receptor is named as receptor-binding motif (RBM).
T230 37290-37443 Sentence denotes The N-region of S2 contains a fusion peptide (FP), two heptapeptide repeat domains (HR1, HR2), a transmembrane domain (TM), and cytoplasmic peptide (CP).
T231 37444-37611 Sentence denotes FP is a short segment composed of mostly hydrophobic residues, such as glycine (G) or alanine (A), which inserts in the host cell membrane to trigger the fusion event.
T232 37612-37795 Sentence denotes HR1 and HR2 are composed of a repetitive heptapeptide with HPPHCPC sequence, where H represents hydrophobic or bulky residues, P polar or hydrophilic residues, and C charged residues.
T233 37796-37894 Sentence denotes HR regions typically fold into α-helices with a hydrophobic interface that drives membrane fusion.
T234 37895-38092 Sentence denotes On the basis of the strong similarity between the S proteins of SARS-CoV and SARS-CoV-2, many researchers early set-out to demonstrate whether both viruses target the same host cell receptor, ACE2.
T235 38093-38251 Sentence denotes Zhou et al. (2020) highlighted that the virus was able to infect cell lines only when they expressed human, bat, civet, and pig (but not mouse) ACE2 receptor.
T236 38252-38443 Sentence denotes Hoffmann et al. (2020b), Ou et al. (2020), and Walls et al. (2020) elegantly outlined that the BHK cell line could be infected by pseudotyped SARS-CoV-2 or SARS-CoV only upon ACE2 expression.
T237 38444-38649 Sentence denotes Conversely, the expression of different human receptors used by other CoVs (hDPP4 and APN, used by MERS CoV and HCoV-229E, respectively) did not enable pseudovirus access to cells (Hoffmann et al., 2020b).
T238 38650-38744 Sentence denotes Taken together, these findings are solid evidence that SARS-CoV-2 engages ACE2 for cell entry.
T239 38745-38968 Sentence denotes Nonetheless, the two viruses were demonstrated by Xia to share also the membrane fusion mechanism, as strongly suggested by the impressive 89.9% sequence identity of S2 between SARS-CoV and SARS-CoV-2 (Xia et al., 2020a,b).
T240 38969-39194 Sentence denotes To date, the cell entry mechanism of SARS-CoV and SARS-CoV-2 has been understood in its general details and it is based on a concerted action of receptor binding and proteolysis of the S protein (Figure 5; Tang et al., 2020).
T241 39195-39386 Sentence denotes Ultrastructural studies showed a metastable “prefusion” V-shaped trimer composed by three S1 heads sitting on top of a trimeric S2 stalk anchored into the virus membrane (Walls et al., 2016).
T242 39387-39604 Sentence denotes The RBD constantly switches between a standing-up (“open”) position for receptor binding and a lying-down (“closed”) configuration, the latter allowing immune evasion (Figure 6; Song et al., 2018; Wrapp et al., 2020).
T243 39605-39723 Sentence denotes Yet only one of the three RBD in trimeric S can flip up at a time and interact with the receptor (Wrapp et al., 2020).
T244 39724-39886 Sentence denotes The second key feature of the fusion mechanism is “priming” by host proteases, which recognize and cleave a short peptide motif at the S1/S2 boundary (Figure 4B).
T245 39887-40250 Sentence denotes This cleavage does not disassemble S1 from S2 in pre-fusion conditions (Belouzard et al., 2009), but the binding interaction of RBD with its receptor, accompanied by a further cleavage in a second site in S2 (S2’site, upstream of FP, Figure 4B), triggers the possible dissociation of S1 and the irreversible refolding of S2 into a “post-fusion” state (Figure 4B).
T246 40251-40486 Sentence denotes In detail, HR1 undergoes a dramatic “jack-knife” conformational change, converting four helical stretches that run in an antiparallel fashion into a single long (∼130 aa) α-helix (Heald-Sargent and Gallagher, 2012; Walls et al., 2017).
T247 40487-40601 Sentence denotes At first, three of these helices assemble into a homotrimeric bundle and stick the FP into the host cell membrane.
T248 40602-40756 Sentence denotes Then, HR2 (one for each S2 chain) fold backward and bind to HR1, yielding the “six-helix bundle fusion core” (6-HB) of post-fusion S2 (Song et al., 2018).
T249 40757-40989 Sentence denotes This conformational foldback brings the FP (at N-terminus of HR1) and the TM (at the C terminus of HR2) close to each other, so that the viral and host cell membranes approach until their outer leaflets merge (hemifusion, Figure 5).
T250 40990-41200 Sentence denotes Eventually the inner leaflets merge (pore formation), enabling a connection between the interior of the virus and the host cell cytoplasm, that allows the delivery of viral genome (Figure 5; Tang et al., 2020).
T251 41201-41250 Sentence denotes FIGURE 5 Coronavirus viral fusion pathway model.
T252 41251-41314 Sentence denotes Initially, the S protein is in the pre-fusion native state (1).
T253 41315-41613 Sentence denotes Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2).
T254 41614-41793 Sentence denotes Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3).
T255 41794-41908 Sentence denotes The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state.
T256 41909-42079 Sentence denotes During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation).
T257 42080-42201 Sentence denotes Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle).
T258 42202-42234 Sentence denotes Adapted from Tang et al. (2020).
T259 42235-42311 Sentence denotes FIGURE 6 Trimeric S protein of SARS-CoV-2 in the ”Closed” and “Open” forms.
T260 42312-42400 Sentence denotes Note the single RBD protruding out of the V-shaped conformation of the protein assembly.
T261 42401-42449 Sentence denotes The structures have been drawn from PDB 6X2C (R.
T262 42450-42513 Sentence denotes Henderson, 10.1101/2020.05.18.10208) by Mol on the PDB website.
T263 42514-42683 Sentence denotes Although not directly related to ACE2, the role of S “priming” by host cell proteases deserves particular attention in the context of SARS-CoV-2 virus entry and tropism.
T264 42684-42896 Sentence denotes Possibly, the most notable feature of SARS-CoV-2 genome, as compared to SARS-CoV and some related bat coronaviruses, is a four basic aminoacid insert (PRRA) at the S1/S2 junction (Figure 4B; Jaimes et al., 2020).
T265 42897-43052 Sentence denotes This site is potentially cleavable by the protease furin, a proprotein convertase widely recognized to activate the fusion machinery of viral glycoprotein.
T266 43053-43285 Sentence denotes Indeed, many authors showed that pseudoviruses bearing SARS-CoV-2 S were already “primed” (i.e., cleaved) at the S1/S2 boundary by furin upon assembly in the cell, at odds with pseudoviruses bearing SARS-CoV S (Shang et al., 2020a).
T267 43286-43679 Sentence denotes SARS-COV-2 shows a large flexibility with regard to protease priming, which may independently occur by a) furin and furin-like proteases intracellularly, b) trypsin-like proteases such as TMPRSS2 that are present on the host cell membrane (particularly on airway epithelial cells), and 3) endosomal cathepsins activated by a drop in pH (e.g., cathepsin L) (Figure 7; Hoffmann et al., 2020a,b).
T268 43680-43831 Sentence denotes This flexibility could be the crucial factor that explain SARS-CoV-2 cell tropism and the peculiar features of COVID-19 symptoms (Jaimes et al., 2020).
T269 43832-44017 Sentence denotes Additionally, the kind of protease “priming” may determine whether the membrane fusion process occur directly at the plasma membrane or at endosomal level (Tang et al., 2020; Figure 7).
T270 44018-44103 Sentence denotes FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells.
T271 44104-44264 Sentence denotes The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell.
T272 44265-44490 Sentence denotes The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA.
T273 44491-44801 Sentence denotes Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles.
T274 44802-44912 Sentence denotes Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell.
T275 44914-44951 Sentence denotes SARS-CoV-2 RBD and Its Receptor, ACE2
T276 44952-45099 Sentence denotes Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV.
T277 45100-45176 Sentence denotes SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005).
T278 45177-45316 Sentence denotes Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020).
T279 45317-45447 Sentence denotes Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy.
T280 45448-45651 Sentence denotes Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor).
T281 45652-45781 Sentence denotes Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner.
T282 45782-45858 Sentence denotes The SARS-CoV-2 RBD sequence was further investigated by structural analysis.
T283 45859-46256 Sentence denotes X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020).
T284 46257-46524 Sentence denotes In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference.
T285 46525-46759 Sentence denotes FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue.
T286 46760-46832 Sentence denotes The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A).
T287 46833-46923 Sentence denotes The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website.
T288 46924-47001 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 47002-47088 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 47089-47249 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 47250-47364 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 47365-47513 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 47514-47705 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 47706-47923 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 47924-48101 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 48102-48345 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 48346-48672 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 48673-48790 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.
T299 48791-48884 Sentence denotes TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2.
T300 48885-48922 Sentence denotes Sequence KD (nM) Method References
T301 48923-48962 Sentence denotes SARS-2 S 14.7 SPR Wrapp et al., 2020
T302 48963-49000 Sentence denotes SARS-2 S 11.2 SPR Lei et al., 2020
T303 49001-49050 Sentence denotes SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020
T304 49051-49103 Sentence denotes SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020
T305 49104-49153 Sentence denotes SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020
T306 49154-49201 Sentence denotes SARS-2 S319–529 44.2 SPR Shang et al., 2020b
T307 49202-49268 Sentence denotes SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020
T308 49269-49334 Sentence denotes SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020
T309 49336-49369 Sentence denotes Structure of the ACE2-RBD Complex
T310 49370-49603 Sentence denotes Previous studies showed that the extracellular Peptidase Domain (PD) of ACE2, which adopts a claw-like morphology, is the interaction site of SARS-CoV RBD (Towler et al., 2004; Li, 2015; Kirchdoerfer et al., 2018; Song et al., 2018).
T311 49604-49778 Sentence denotes More specifically, ACE2 engages SARS-CoV RBD by establishing contacts with the 424–494 residue domain, which is referred to as Receptor Binding Motif (RBM) (Li et al., 2005).
T312 49779-50059 Sentence denotes In spite of the recent emergence of SARS-CoV-2, multiple authors have already highlighted the structure of ACE2/SARS-CoV-2 RBD complex by either X-ray (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020) or cryo-EM (Walls et al., 2020; Wrapp et al., 2020; Yan et al., 2020).
T313 50060-50170 Sentence denotes Pleasantly, all data converged to a consistent tridimensional arrangement of the receptor (Wang et al., 2020).
T314 50171-50288 Sentence denotes In the “closed” conformation of S protein, the RBD is buried at the interface between protomers (Walls et al., 2020).
T315 50289-50471 Sentence denotes Only in the “open” S conformation, RBD engages PD of ACE2 (Wrapp et al., 2020), and the complex may involve a dimeric ACE2 that accommodates two S protein trimers (Yan et al., 2020).
T316 50472-50661 Sentence denotes In keeping with their sequence similarity, strong structural homology was found between ACE2/SARS-CoV RBD and ACE2/SARS-CoV-2 RBD (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020).
T317 50662-50850 Sentence denotes SARS-CoV-2 RBM spans from residue 438–506 of S sequence and, likewise SARS-CoV RBM, it approaches the outer surface of ACE2 by a gently concave surface with a ridge on one side (Figure 8).
T318 50851-51016 Sentence denotes The concave surface is made up by the two short β5 and β6 sheets of the external RBD subdomain, whereas the ridge contains the β5/β6 loop (loop 1: residues 474–489).
T319 51017-51118 Sentence denotes A second smaller loop (loop 2: residues 498–505) is visible on the other side of the concave surface.
T320 51119-51384 Sentence denotes Inspection of the complex structure and molecular dynamics (MD) highlighted that the motifs 453–456 (in β5), 484–489 (in the loop 1), and 500–505 (in the loop 2) are at the basis of the largest differences between SARS-CoV-2 and SARS-CoV RBM interactions with ACE2.
T321 51385-51639 Sentence denotes SARS-CoV RBM ridge contains a Pro-Pro-Ala motif that is replaced by Gly-Val-Glu-Gly in SARS-CoV-2 (residues 482–485), yielding a more compact loop able to engage more interactions with proximal ACE2 residues (e.g., Ser19 and Gln24) (Shang et al., 2020b).
T322 51640-51848 Sentence denotes Additionally, Phe486 of SARS-CoV-2 RBM (which replaces Ile of SARS) inserts into a hydrophobic pocket on the receptor surface, establishing strong aromatic interactions with Tyr83 of ACE2 (Wang et al., 2020).
T323 51849-51944 Sentence denotes Asn501 in loop 2 further engages recognized hotspots on the ACE2 surface (Shang et al., 2020b).
T324 51945-52096 Sentence denotes Consistently, MD studies confirmed that loop 1 and 2 are much more rigid in RBM-ACE2 complex of SARS-CoV-2 with respect to SARS (Brielle et al., 2020).
T325 52097-52217 Sentence denotes These subtle structural differences probably account for the higher affinity of SARS-CoV-2 for ACE2 (Wang et al., 2020).
T326 52218-52427 Sentence denotes Interestingly, MD simulations suggest that the difference in affinity is largely due to the solvation energy, emphasizing the relevant role of hydrophobic patches in RBM/ACE2 binding surface (He et al., 2020).
T327 52428-52695 Sentence denotes It is worth noting that the RBD-receptor engagement is the crucial effector of viral-host interaction, which eventually determines viral host range, and in tandem with the host proteases is responsible for virus tropism and pathogenicity (Millet and Whittaker, 2015).
T328 52696-52930 Sentence denotes Structure-guided sequence analysis has suggested that several mammals, including pets such as cats and dogs, host ACE2 receptors that could bind effectively to SARS-CoV-2 S protein and propagate COVID-19 infection (Luan et al., 2020).
T329 52931-53013 Sentence denotes Yet, no correlation between genetic distance and the S/ACE2 interaction was found.
T330 53014-53225 Sentence denotes In this context, a third human CoV, hCoV-NL63, has been previously found to use ACE2 for cell entry (Hofmann et al., 2005), although its S1 sequence is rather dissimilar from SARS (23.4%) and SARS-CoV-2 (29.2%).
T331 53226-53398 Sentence denotes In spite of this, the structures of hCoV-NL63 (Wu et al., 2009) and SARS-CoV RBD (Li et al., 2005) were found to engage some sterically overlapping sites in ACE (Li, 2015).
T332 53399-53559 Sentence denotes This homology can be transitively extended to SARS-CoV-2, suggesting these three CoVs have evolved to recognize a “hotspot” region in ACE2 for receptor binding.
T333 53560-53753 Sentence denotes This might represent a critical feature for the appearance of novel CoV able to infect humans in the future, as it is known that at least three more bat CoVs bind ACE2 (Hoffmann et al., 2020b).
T334 53754-53977 Sentence denotes Indeed, bat RaTG13 CoV binds ACE2 and contains a similar four-residue motif in the ACE2 binding ridge of RBM, suggesting that SARS-CoV-2 could have evolved from RaTG13 or a yet-unknown related bat CoV (Shang et al., 2020b).
T335 53979-54020 Sentence denotes The Controversial Role of ACE2 Expression
T336 54021-54261 Sentence denotes Epidemiological data consistently show that the COVID-19 patients at highest risk of a poor prognosis are males older than 60 years with chronic underlying diseases, mostly hypertension, cardiovascular diseases and type-2 diabetes mellitus.
T337 54262-54444 Sentence denotes Clinical reports have been rapidly delivered from all over the world, and meta-analyses assessing the prevalence of comorbidities and their impact on prognosis are already available.
T338 54445-54692 Sentence denotes A meta-analysis pooling data from seven studies following a total number of 1,576 infected patients from hospitals in China found that the most prevalent comorbidities were hypertension (21.1%), diabetes (9.7%), and cardiovascular diseases (8.4%).
T339 54693-54901 Sentence denotes These increased the risk of developing a more serious disease (i.e., requiring intensive care treatment), with odds ratios ranging from 2.4 (hypertension) to 3.4 (cardiovascular disease) (Yang et al., 2020b).
T340 54902-55177 Sentence denotes These findings have been confirmed in the analysis performed by the Chinese Center for Disease Control and Prevention in a huge sample of 72314 COVID-19 cases (Epidemiology Working Group for Ncip Epidemic Response and Chinese Center for Disease Control and Prevention, 2020).
T341 55178-55331 Sentence denotes A study with 1591 Italian patients, similarly, reported a significant association between hypertension and mortality in Intensive Care Unit (63 vs. 40%).
T342 55332-55476 Sentence denotes This series reported an even higher prevalence of hypertension (49%), diabetes (17%), and cardiovascular disease (21%) (Grasselli et al., 2020).
T343 55477-55665 Sentence denotes Diabetes has been reported to predict the occurrence of ARDS (HR = 1.44), acute kidney injury (HR = 3.01), septic shock (HR = 1.95), and all-cause mortality (HR = 1.70) (Zhu et al., 2020).
T344 55666-55824 Sentence denotes Notably, poor glycemic control was significantly associated with worse clinical outcomes, namely multi-organ injuries and higher mortality (Zhu et al., 2020).
T345 55825-55906 Sentence denotes Obesity has also emerged as an important factor in determining COVID-19 severity.
T346 55907-56175 Sentence denotes Indeed, obesity was more frequent in patients admitted to critical care for SARS-CoV-2 as compared to the general population; moreover, the BMI was positively related to the need for invasive mechanical ventilation and mortality (Drucker, 2020; Simonnet et al., 2020).
T347 56176-56318 Sentence denotes The RAAS system is the target of widely used anti-hypertensive drugs, such as ACE-inhibitors (ACEI) and Ang-II type 1 receptor blockers (ARB).
T348 56319-56531 Sentence denotes Several experimental studies reported that, although not directly affecting ACE2 activity, these drugs are able to upregulate its expression (Ishiyama et al., 2004; Ferrario et al., 2005; Gallagher et al., 2008).
T349 56532-56764 Sentence denotes Increased expression of ACE2 has also been reported to facilitate SARS-CoV infection in several experimental models and postulated to act in the same way for SARS-CoV-2 (Li et al., 2003; Hofmann et al., 2004; Perrotta et al., 2020).
T350 56765-56935 Sentence denotes Hence, following the SARS-CoV-2 outbreak, it has been speculated that the use of ACEI and ARB could increase viral invasion and should therefore be temporarily suspended.
T351 56936-57404 Sentence denotes This topic has been abundantly debated in the last few months (March–May 2020), with contradictory views (Bavishi et al., 2020; Buckley et al., 2020; Danser et al., 2020; Fang et al., 2020; Huang Z. et al., 2020; Kreutz et al., 2020; Kuster et al., 2020; Mourad and Levy, 2020; Park et al., 2020; Rico-Mesa et al., 2020; Sommerstein et al., 2020; South et al., 2020; Tignanelli et al., 2020; Vaduganathan et al., 2020; Verdecchia et al., 2020b; Zhang P. et al., 2020).
T352 57405-57794 Sentence denotes As a consequence of this debate, several clinical societies have stated that suspension of ACEI and ARB is not justified on the basis of the present scientific evidence, although a recent BMJ editorial (Aronson and Ferner, 2020) suggested to consider stopping ACE inhibitors or angiotensin receptor blockers in patients with mild hypertension who are at high risk of coronavirus infection.
T353 57795-58020 Sentence denotes On the other hand, a different viewpoint is based on the intriguing observation that several conditions increasing the risk of viral infection and disease severity are all characterized by a certain degree of ACE2 deficiency.
T354 58021-58208 Sentence denotes As discussed above (section “Structure of ACE2”) ACE2 deficiency has been suggested to play a significant role in the pathophysiology of hypertension, cardiovascular disease and diabetes.
T355 58209-58406 Sentence denotes The role of ACE2 expression in the panel of comorbidities correlated to SARS-CoV-2 is a matter of intense still unsolved debate, as brilliantly revised by Shyh et al. (2020) in a very recent paper.
T356 58407-58546 Sentence denotes On the whole, there is still uncertainty about the relationship between ACE2 density on cell membrane and the fate of SARS-CoV-2 infection.
T357 58547-58888 Sentence denotes An interesting speculation which could reconcile the two position comes from the hypothesis that while ACE2 is for sure the entry door for the virus, once the infection has evolved, there is the subsequent downregulation of ACE2, responsible for the precipitating of respiratory distress, as showed also in animal models (Kuba et al., 2005).
T358 58889-59061 Sentence denotes It should be pointed out that the great clinical impact of this issue has encouraged discussions that are largely based on indirect speculations rather than objective data.
T359 59062-59355 Sentence denotes Data from appropriate clinical trials are still lacking, although a retrospective multicenter study on more than 1,000 patients with COVID-19 and hypertension treated with ACEI or ARB revealed that the use of these drugs was associated with lower mortality from all cause (Bosso et al., 2020).
T360 59356-59760 Sentence denotes A definite conclusion would require specific prospective clinical trials, which are still running: https://clinicaltrials.gov/ct2/show/NCT04312009 is a multi-centered double blind trial with the aim to test the role of ARB in patients with COVID-19 and https://clinicaltrials.gov/ct2/show/NCT04331574 is another trial evaluating the outcome of patients with COVID-19 in therapy with either ACEI and ARBS.
T361 59761-60316 Sentence denotes In the meanwhile, partial but important information might be obtained by circumscribed experimental and clinical investigations focused some on crucial issues, namely: fate of SARS-CoV-2 infection in human cells manipulated in order to modify ACE2 density; correlation of ACE2 density (in different cell types) and clinical course in human patients; potential role of additional proteins interacting with ACE2, such as the membrane transporter SIT1, which appears to be associated with COVID-19 prognosis and is also affected by anti-hypertensive therapy.
T362 60318-60366 Sentence denotes ACE2 and the Inflammatory Response to SARS-CoV-2
T363 60367-60533 Sentence denotes Differently from other flu-like viral infections, COVID19 showed a relatively high lethality, although the latter was quite different in different geographical areas.
T364 60534-60693 Sentence denotes The appearance of ARDS and acute severe lung injury was initially regarded as the main insult, and patients underwent the typical treatment developed for ARDS.
T365 60694-61009 Sentence denotes However, more recent evidence from autopsy series revealed that COVID-19 is a systemic disease, in which interstitial pneumonia is associated with extensive microvascular damage, which is not limited to the lungs and leads to fibrin deposition, neutrophils trapping in microvasculature, and arteriolar microthrombi.
T366 61010-61164 Sentence denotes Moreover, cardiovascular involvement has been observed, occasionally leading to myocardial injury and sudden death after weeks from the initial infection.
T367 61165-61336 Sentence denotes These findings are crucial to optimize the treatment of COVID-19 patients, hopefully improving the prognosis (Buja et al., 2020; Carsana et al., 2020; Magro et al., 2020).
T368 61337-61485 Sentence denotes Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection.
T369 61486-61624 Sentence denotes Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia.
T370 61625-61723 Sentence denotes In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required.
T371 61724-61849 Sentence denotes These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people.
T372 61850-62165 Sentence denotes Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020).
T373 62166-62284 Sentence denotes The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood.
T374 62285-62498 Sentence denotes As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes).
T375 62499-62627 Sentence denotes This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020).
T376 62628-62878 Sentence denotes The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016).
T377 62879-63125 Sentence denotes In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane.
T378 63126-63571 Sentence denotes One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9).
T379 63572-63679 Sentence denotes FIGURE 9 Possible role of ACE2 in the molecular mechanisms involved in the “cytokine storm” of SARS-CoV-2.
T380 63680-63901 Sentence denotes In the SARS-CoV-2 infection, pyroptosis has been demonstrated to be active in macrophages, being viroporin 3a a trigger for NLRP3 with subsequent production of proinflammatory cytokines, such as IL-1β (Chen et al., 2019).
T381 63902-64040 Sentence denotes In COVID-19 patients, the pyroptosis activation has been indirectly demonstrated by the high serum level of IL-1β (Huang C. et al., 2020).
T382 64041-64228 Sentence denotes Moreover, the severe leucopoenia and lymphopenia, commonly showed in COVID-19 pneumonia and associated with poor prognosis, are likely due to lymphocyte injury by pyroptosis (Yang, 2020).
T383 64229-64354 Sentence denotes Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system.
T384 64355-64651 Sentence denotes It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018).
T385 64652-64996 Sentence denotes The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release.
T386 64997-65236 Sentence denotes Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020).
T387 65237-65333 Sentence denotes The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm.
T388 65334-65530 Sentence denotes The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).
T389 65531-65619 Sentence denotes ACE2 shedding is an additional mechanism contributing to inflammation (Fu et al., 2020).
T390 65620-65873 Sentence denotes ACE2 shedding consists in proteolytic cleavage of the protein ectodomain and leads to the release of enzymatically active soluble ACE2 (sACE), whose action is not completely understood, but might enhance the pro-inflammatory response (Guy et al., 2005).
T391 65874-66089 Sentence denotes ADAM 17 and disintegrin are able to shed not only TNFα but also a variety of membrane-anchored enzymes, including ACE2 (Black et al., 1997; Palau et al., 2020), as demonstrated by Lambert in 2005 (Guy et al., 2005).
T392 66090-66406 Sentence denotes In their experiment, human embryonic kidney cells (HEK293) expressing human ACE2 (HEK-ACE2) were treated with phorbol myristate acetate stimulation and the production of a polypeptide of 105 kDa was demonstrated by western blot analysis, suggesting the occurrence of a proteolytic shedding in the ectodomain of ACE2.
T393 66407-66627 Sentence denotes Subsequently, they demonstrated that the cleavage was performed by ADAM17, incubating cells with a specific hydroxamic acid-based metalloproteinase inhibitor, namely TAPI-1 (TNFα protease inhibitor 1) (Guy et al., 2005).
T394 66628-66745 Sentence denotes ACE2 shedding seems to be inducible by specific stimuli produced either by a viral infection or by the immune system.
T395 66746-66859 Sentence denotes Jia et al. (2009) confirmed ACE2 shedding in differentiated primary airway epithelial cells and Calu-3-cell line.
T396 66860-67068 Sentence denotes Furthermore, they demonstrated that the incubation with IL-1β at the dosage of 100 ng/ml and TNF α 100 ng/ml induced ACE2 shedding and sACE release, with a maximum after 18 h of incubation (Jia et al., 2009).
T397 67069-67204 Sentence denotes These findings suggest that an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection.
T398 67205-67389 Sentence denotes Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).
T399 67390-67549 Sentence denotes Other conditions have been assumed to be involved in the susceptibility to SARS-CoV-2 and among them vitamin D deficiency was proposed as a credible candidate.
T400 67550-67711 Sentence denotes The interesting candidate could be identified as a modifiable risk factor (hypovitaminosis D) and a potential tool in COVID-19 prevention or ancillary treatment.
T401 67712-68368 Sentence denotes The rationale has been summarized by Grant et al. in a recent review on the evidence supporting a possible correlation between vitamin D and SARS-CoV-2 risk: (i) the seasonal flare of SARS-CoV-2 which coincides with the nadir of vitamin D levels, (ii) the association between hypovitaminosis D and pulmonary infections together with the demonstrated protective role in acute respiratory infections, in adults (iii) the anti-inflammatory role of vitamin D which could be of benefit against the so called “cytokine storm,” which seems to be a major player in SARS-CoV-2 morbidity and mortality (Martineau et al., 2017; Zhou et al., 2019; Grant et al., 2020).
T402 68370-68398 Sentence denotes ACE2 as a Therapeutic Target
T403 68399-68487 Sentence denotes As evidence builds up, ACE2 rapidly emerged as a specific target for COVID-19 treatment.
T404 68488-68792 Sentence denotes Since this enzyme was identified as the SARS-CoV-2 receptor (Zhou et al., 2020), several approaches to address ACE2 mediated infection have been described (Li Y. et al., 2020; Zhang H. et al., 2020), with the aim to prevent host cell entry and subsequent viral replication, as well as severe lung injury.
T405 68793-68846 Sentence denotes Potential therapeutic approaches include (Figure 10):
T406 68847-68958 Sentence denotes FIGURE 10 Schematic representation of the potential therapeutic approaches to address ACE2 mediated infection.
T407 68959-69163 Sentence denotes Exogenous administration of soluble recombinant human ACE 2 sequesters circulating viral particles, while specific ACE2 blockers bind the receptor, impeding the S-protein interaction with the host target.
T408 69164-69166 Sentence denotes 1.
T409 69168-69182 Sentence denotes ACE2 blockers;
T410 69183-69185 Sentence denotes 2.
T411 69187-69220 Sentence denotes Exogenous administration of ACE2.
T412 69222-69235 Sentence denotes ACE2 Blockers
T413 69236-69486 Sentence denotes Blockade of ACE2 receptor could be achieved through specific antibodies (Li et al., 2003), rationally designed small molecules (Dales et al., 2002; Huentelman et al., 2004; Gross et al., 2020; Pillaiyar et al., 2020) or peptides (Huang et al., 2003).
T414 69487-69675 Sentence denotes Although their efficacy needs to be confirmed, some of these agents are currently available on the market and have been show to effectively block SARS-CoV invasion (Li S.-R. et al., 2020).
T415 69676-70003 Sentence denotes For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004).
T416 70004-70202 Sentence denotes Therefore, although ACE2 catalytic site is distinct from the S-protein-binding domain, NAAE exerts dual inhibitory effects on ACE2 catalytic activity and SARS binding (Adedeji and Sarafianos, 2014).
T417 70203-70499 Sentence denotes However, since a protecting role for ACE2 receptor against virus-induced acute lung injury in infections with SARS coronavirus has not been excluded (Imai et al., 2005; Kuba et al., 2005; Li S.-R. et al., 2020), the choice of ACE2 inhibition as therapeutic approach should be carefully evaluated.
T418 70501-70533 Sentence denotes Exogenous Administration of ACE2
T419 70534-70942 Sentence denotes The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a).
T420 70943-71122 Sentence denotes A pilot clinical study is currently investigating the efficiency of a recombinant human angiotensin-converting enzyme 2 (rhACE2) in patients with COVID-19 (Zhang H. et al., 2020).
T421 71123-71327 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 71328-71683 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 71684-71890 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 71891-72052 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 72053-72259 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.
T426 72260-72489 Sentence denotes Additionally, the availability of ACE2 nanoparticles applied to nose filters, chewing gums, clothes, filters and gloves could be of help in sequestering the virus thus preventing its entry into the host (Aydemir and Ulusu, 2020).
T427 72490-72722 Sentence denotes Prevention virus transmission could represent a more convenient strategy than therapeutic interventions on viral infection, avoiding interference with ACE2 and disturbance of the finely regulated RAAS axis (Aydemir and Ulusu, 2020).
T428 72724-72747 Sentence denotes ACE2 and Other Diseases
T429 72748-72802 Sentence denotes ACE2 is a multiform protein (Feng et al., 2010, 2011).
T430 72803-72993 Sentence denotes As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013).
T431 72994-73106 Sentence denotes Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis.
T432 73107-73224 Sentence denotes Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012).
T433 73225-73322 Sentence denotes Moreover, ACE2 participates in the regulation of metabolism, particularly of glucose homeostasis.
T434 73323-73430 Sentence denotes In the pancreas, activation of the ACE2-Ang1-7-MasR pathway improves insulin secretion (Yuan et al., 2013).
T435 73431-73617 Sentence denotes Obesity and high-fat diets cause a reduction in ACE2 expression in the adipose tissue, which in turn results in increased blood pressure (Gupte et al., 2008, 2012; Carsana et al., 2020).
T436 73618-73763 Sentence denotes A role for ACE2 is emerging in Alzheimer disease, since it has been shown that ACE2 can hydrolyse Beta amyloid peptides (Zou et al., 2007, 2013).
T437 73764-73847 Sentence denotes There is also increasing evidence that the RAAS system may be implicated in cancer.
T438 73848-74048 Sentence denotes ACE2 was found to inhibit cancer cell growth, metastasis, and angiogenesis in breast (Yu et al., 2016; Zhang Q. et al., 2019), pancreatic (Zhou et al., 2011), and colon cancer (Bernardi et al., 2012).
T439 74049-74258 Sentence denotes Another study pointed out that hepatocellular carcinoma patients with higher levels of ACE2 had longer survival times, suggesting a positive link between ACE2 expression and better prognosis (Ye et al., 2015).
T440 74259-74425 Sentence denotes Studies on human xenografts in mice clearly indicated that ACE2 inhibited tumor growth by suppressing invasion and angiogenesis in Non-Small Cell Lung Cancer (NSCLC).
T441 74426-74699 Sentence denotes Remarkably, the same group demonstrated that overexpression of ACE2 promotes the expression of E-cadherin at expenses of mesenchymal markers such as vimentin, and thereby inhibits the epithelial-mesenchymal transition in NSCLC models (Feng et al., 2010; Qian et al., 2013).
T442 74700-74906 Sentence denotes The discovery that lung cancer patients that harbor COVID-19 display more severe symptoms (Liang et al., 2020) set out intensive research on the possible connection between malignancies and ACE2 expression.
T443 74907-75024 Sentence denotes A thorough bioinformatics analysis of the TCGA dataset on several kinds of cancer (Chai et al., 2020) has shown that:
T444 75025-75093 Sentence denotes (1) Mutation and amplification of ACE2 gene are frequent in cancer.
T445 75094-75199 Sentence denotes Yet, hot-spot mutation sites were never observed, as ACE2 mutations were distributed across all 18 exons.
T446 75200-75456 Sentence denotes (2) ACE2 transcription was upregulated in six tumors: colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and lung adenocarcinoma (LUAD).
T447 75457-75544 Sentence denotes Interestingly, ACE2 transcription was unchanged in lung squamous cell carcinoma (LUSC).
T448 75545-75689 Sentence denotes (3) ACE2 transcription was downregulated in three tumors: testicular germ cell (TGCT), thyroid carcinoma (THCA), and kidney chromophobe (KICH).
T449 75690-75845 Sentence denotes (4) Changes of ACE2 transcription were epigenetic in nature, as both mutation and copy variation of ACE2 did not correlate with its up- or downregulation.
T450 75846-75950 Sentence denotes (5) In most cases, changes of ACE2 transcription strongly correlated with methylation in ACE2 promoter.
T451 75951-76081 Sentence denotes More specifically, decreased methylation levels correlated with upregulation, whereas increased methylation led to downregulation.
T452 76082-76169 Sentence denotes (6) No prognostic role of ACE2 expression on patient’s survival could be demonstrated.
T453 76170-76290 Sentence denotes These data confirm the remarkable role of methylation in determining the ACE2 expression, as described in paragraph 2.2.
T454 76291-76636 Sentence denotes Interestingly, a second bioinformatics study on Oncomine and TCGA databases gave slightly different results in terms of tumor-associated ACE2 expression changes, but confirmed the role of promoter hypomethylation in KIRP and uterine corpus endometrial carcinoma (UCEC) where ACE2 transcription was significantly upregulated (Yang et al., 2020a).
T455 76638-76648 Sentence denotes Conclusion
T456 76649-76772 Sentence denotes From the structural point of view ACE2 is closely related to ACE, and its discovery was a by-product of ACE investigations.
T457 76773-76887 Sentence denotes However, this macromolecule has soon showed peculiar functional properties and has attracted increasing attention.
T458 76888-77139 Sentence denotes The expression of ACE2 in the heart, kidney and vascular system pointed to a role in the regulation of blood pressure and cardiovascular homeostasis, possibly as a counterbalance to ACE activation, but this hypothesis now appears to be too simplistic.
T459 77140-77338 Sentence denotes Additional functions of ACE2 are strongly suggested by its capability to modulate cytokine metabolism and the inflammatory reaction, as well as by its remarkable expression in the respiratory tract.
T460 77339-77549 Sentence denotes The recent COVID-19 pandemic has put ACE2 in the spotlight, since it has been identified as the initial target of the SARS-Cov and SARS-Cov2 viruses, representing the receptor responsible for cellular adhesion.
T461 77550-77783 Sentence denotes Recent investigations have clarified the molecular details of the interaction of ACE2 with the spike glycoprotein present in this class of coronaviruses, and have partly unraveled the mechanism of protein cleavage and cellular entry.
T462 77784-78082 Sentence denotes ACE2 density on cell surface and ACE2-modulated inflammatory reactions have been suggested to be important determinants of COVID-19 susceptibility and clinical course, while drugs interfering with ACE2 expression, availability and processing are under investigation as potential therapeutic agents.
T463 78083-78289 Sentence denotes However, several crucial issues concerning the link between ACE2 and COVID-19 pathophysiology are still unclear, pointing to the need for focused experimental investigations and prospective clinical trials.
T464 78291-78311 Sentence denotes Author Contributions
T465 78312-78414 Sentence denotes FS, GR, SS, LB, BS, and RB wrote the first draft of the manuscript and prepared the table and figures.
T466 78415-78450 Sentence denotes RZ revised and integrated the text.
T467 78451-78510 Sentence denotes All authors decided upon the general outline of the review.
T468 78512-78532 Sentence denotes Conflict of Interest
T469 78533-78705 Sentence denotes The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
T470 78707-78715 Sentence denotes Funding.
T471 78716-78799 Sentence denotes This work is supported by the PRA 2020-22 to GR, granted by the University of Pisa.
T472 78800-78854 Sentence denotes 1 https://www.preprints.org/manuscript/202003.0295/v1

LitCovid-sample-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 277-281 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T2 621-642 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T3 644-650 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T4 656-665 Body_part denotes intestine http://purl.obolibrary.org/obo/UBERON_0000160
T5 690-707 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T6 3030-3035 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T7 4208-4212 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T8 5996-6001 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T9 7014-7019 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T10 7160-7165 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T11 7478-7483 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T12 7495-7501 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T13 7752-7758 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T14 11187-11193 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T15 11541-11547 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T16 11651-11657 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T17 11804-11808 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T18 12104-12110 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T19 12202-12226 Body_part denotes renin-angiotensin system http://purl.obolibrary.org/obo/UBERON_0018229
T20 12742-12748 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T21 14830-14834 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T22 14878-14882 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T23 15324-15328 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T24 15409-15413 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 15414-15420 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T26 15764-15768 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T27 15782-15788 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T28 16649-16654 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T29 18356-18362 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T30 18562-18583 Body_part denotes cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535
T31 18588-18594 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T32 18797-18808 Body_part denotes vasculature http://purl.obolibrary.org/obo/UBERON_0002049
T33 18904-18915 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T34 18979-18986 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T35 19045-19051 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T36 19081-19097 Body_part denotes coronary vessels http://purl.obolibrary.org/obo/UBERON_0005985
T37 19172-19176 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T38 19251-19257 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T39 19258-19279 Body_part denotes interlobular arteries http://purl.obolibrary.org/obo/UBERON_0004723
T40 19344-19349 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T41 19405-19414 Body_part denotes mesangium http://purl.obolibrary.org/obo/UBERON_0002319
T42 19419-19441 Body_part denotes glomerular endothelium http://purl.obolibrary.org/obo/UBERON_0004189
T43 19449-19455 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T44 19491-19500 Body_part denotes sinusoids http://purl.obolibrary.org/obo/UBERON_0003909
T45 19508-19513 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T46 19665-19671 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T47 19679-19685 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T48 19687-19698 Body_part denotes lymph nodes http://purl.obolibrary.org/obo/UBERON_0000029
T49 19704-19715 Body_part denotes bone marrow http://purl.obolibrary.org/obo/UBERON_0002371
T50 19761-19766 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T51 19961-19966 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T52 20144-20159 Body_part denotes sinoatrial node http://purl.obolibrary.org/obo/UBERON_0002351
T53 20259-20264 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T54 20328-20341 Body_part denotes aortic valves http://purl.obolibrary.org/obo/UBERON_0002137
T55 20532-20538 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T56 20891-20905 Body_part denotes distal tubules http://purl.obolibrary.org/obo/UBERON_0004135
T57 20922-20926 Body_part denotes duct http://purl.obolibrary.org/obo/UBERON_0000058
T58 21077-21094 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065
T59 21196-21202 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344
T60 21211-21217 Body_part denotes larynx http://purl.obolibrary.org/obo/UBERON_0001737
T61 21219-21226 Body_part denotes trachea http://purl.obolibrary.org/obo/UBERON_0003126
T62 21228-21235 Body_part denotes bronchi http://purl.obolibrary.org/obo/UBERON_0002185
T63 21240-21244 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T64 21310-21325 Body_part denotes oral epithelium http://purl.obolibrary.org/obo/UBERON_0002424
T65 21474-21478 Body_part denotes face http://purl.obolibrary.org/obo/UBERON_0001456
T66 21729-21752 Body_part denotes upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0001557
T67 21800-21814 Body_part denotes lamina propria http://purl.obolibrary.org/obo/UBERON_0000030
T68 21857-21862 Body_part denotes gland http://purl.obolibrary.org/obo/UBERON_0002530
T69 21863-21867 Body_part denotes duct http://purl.obolibrary.org/obo/UBERON_0000058
T70 21868-21878 Body_part denotes epithelium http://purl.obolibrary.org/obo/UBERON_0000483
T71 21887-21891 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T72 22409-22414 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T73 22453-22459 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T74 22460-22471 Body_part denotes endothelium http://purl.obolibrary.org/obo/UBERON_0001986
T75 22490-22499 Body_part denotes bile duct http://purl.obolibrary.org/obo/UBERON_0002394
T76 22729-22744 Body_part denotes small intestine http://purl.obolibrary.org/obo/UBERON_0002108
T77 22760-22768 Body_part denotes duodenum http://purl.obolibrary.org/obo/UBERON_0002114
T78 22770-22777 Body_part denotes jejunum http://purl.obolibrary.org/obo/UBERON_0002115
T79 22783-22788 Body_part denotes ileum http://purl.obolibrary.org/obo/UBERON_0002116
T80 22820-22825 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T81 22833-22839 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T82 22847-22862 Body_part denotes digestive tract http://purl.obolibrary.org/obo/UBERON_0001555
T83 22876-22883 Body_part denotes stomach http://purl.obolibrary.org/obo/UBERON_0000945
T84 22888-22893 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T85 23114-23120 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T86 23142-23162 Body_part denotes islets of Langerhans http://purl.obolibrary.org/obo/UBERON_0000006
T87 23249-23254 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T88 23265-23278 Body_part denotes telencephalon http://purl.obolibrary.org/obo/UBERON_0001893
T89 23325-23330 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T90 23431-23436 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T91 23440-23446 Body_part denotes lamina http://purl.obolibrary.org/obo/UBERON_0000957
T92 23459-23476 Body_part denotes subfornical organ http://purl.obolibrary.org/obo/UBERON_0002219
T93 23545-23558 Body_part denotes area postrema http://purl.obolibrary.org/obo/UBERON_0002162
T94 23560-23589 Body_part denotes nucleus of the solitary tract http://purl.obolibrary.org/obo/UBERON_0009050
T95 23649-23678 Body_part denotes rostral ventrolateral medulla http://purl.obolibrary.org/obo/UBERON_0005807
T96 23760-23765 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955
T97 23835-23850 Body_part denotes piriform cortex http://purl.obolibrary.org/obo/UBERON_0004725
T98 23865-23880 Body_part denotes caudate putamen http://purl.obolibrary.org/obo/UBERON_0005383
T99 23882-23901 Body_part denotes hypoglossal nucleus http://purl.obolibrary.org/obo/UBERON_0002871
T100 23906-23926 Body_part denotes primary motor cortex http://purl.obolibrary.org/obo/UBERON_0001384
T101 24169-24175 Body_part denotes retina http://purl.obolibrary.org/obo/UBERON_0000966
T102 24314-24330 Body_part denotes endocrine system http://purl.obolibrary.org/obo/UBERON_0000949
T103 24375-24402 Body_part denotes female reproductive systems http://purl.obolibrary.org/obo/UBERON_0000474
T104 24413-24419 Body_part denotes testis http://purl.obolibrary.org/obo/UBERON_0000473
T105 24658-24664 Body_part denotes stroma http://purl.obolibrary.org/obo/UBERON_0003891
T106 25038-25042 Body_part denotes skin http://purl.obolibrary.org/obo/UBERON_0000014
T107 25074-25084 Body_part denotes cell layer http://purl.obolibrary.org/obo/UBERON_0000119
T108 25125-25135 Body_part denotes cell layer http://purl.obolibrary.org/obo/UBERON_0000119
T109 25139-25153 Body_part denotes hair follicles http://purl.obolibrary.org/obo/UBERON_0002073
T110 25191-25207 Body_part denotes sebaceous glands http://purl.obolibrary.org/obo/UBERON_0001821
T111 25279-25294 Body_part denotes sebaceous gland http://purl.obolibrary.org/obo/UBERON_0001821
T112 25475-25481 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T113 25508-25522 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T114 25766-25771 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T115 25776-25782 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T116 25850-25856 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T117 26616-26621 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T118 27540-27546 Body_part denotes organs http://purl.obolibrary.org/obo/UBERON_0000062
T119 27558-27563 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T120 27565-27572 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T121 29370-29383 Body_part denotes blood vessels http://purl.obolibrary.org/obo/UBERON_0001981
T122 30012-30017 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T123 30700-30704 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T124 30803-30810 Body_part denotes vessels http://purl.obolibrary.org/obo/UBERON_0000055
T125 30876-30879 Body_part denotes arm http://purl.obolibrary.org/obo/UBERON_0001460
T126 30922-30926 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T127 31017-31021 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T128 31228-31232 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T129 31573-31579 Body_part denotes vessel http://purl.obolibrary.org/obo/UBERON_0000055
T130 31594-31598 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T131 31910-31914 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T132 32587-32591 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T133 34157-34163 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T134 35465-35470 Body_part denotes shell http://purl.obolibrary.org/obo/UBERON_0006612
T135 40424-40429 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T136 40685-40690 Body_part denotes helix http://purl.obolibrary.org/obo/UBERON_0002488
T137 41027-41031 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T138 42063-42067 Body_part denotes pore http://purl.obolibrary.org/obo/UBERON_0008915
T139 48319-48332 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T140 55557-55563 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T141 55769-55774 Body_part denotes organ http://purl.obolibrary.org/obo/UBERON_0000062
T142 57808-57812 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T143 60574-60578 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T144 62453-62466 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T145 63995-64000 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T146 66127-66133 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T147 66731-66744 Body_part denotes immune system http://purl.obolibrary.org/obo/UBERON_0002405
T148 68780-68784 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T149 70282-70286 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T150 70903-70907 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T151 71817-71829 Body_part denotes blood vessel http://purl.obolibrary.org/obo/UBERON_0001981
T152 71850-71856 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T153 72324-72328 Body_part denotes nose http://purl.obolibrary.org/obo/UBERON_0000004
T154 72900-72906 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T155 73330-73338 Body_part denotes pancreas http://purl.obolibrary.org/obo/UBERON_0001264
T156 73502-73516 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T157 73553-73558 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T158 73926-73932 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T159 74011-74016 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T160 74405-74409 Body_part denotes Lung http://purl.obolibrary.org/obo/UBERON_0002048
T161 74719-74723 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T162 75255-75260 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155
T163 75284-75290 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T164 75364-75370 Body_part denotes rectum http://purl.obolibrary.org/obo/UBERON_0001052
T165 75394-75401 Body_part denotes stomach http://purl.obolibrary.org/obo/UBERON_0000945
T166 75429-75433 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T167 75508-75512 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T168 75633-75640 Body_part denotes thyroid http://purl.obolibrary.org/obo/UBERON_0002046
T169 75663-75669 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T170 76524-76530 Body_part denotes corpus http://purl.obolibrary.org/obo/UBERON_3000645
T171 76918-76923 Body_part denotes heart http://purl.obolibrary.org/obo/UBERON_0000948
T172 76925-76931 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T173 76936-76951 Body_part denotes vascular system http://purl.obolibrary.org/obo/UBERON_0007798
T174 76991-76996 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T175 77320-77337 Body_part denotes respiratory tract http://purl.obolibrary.org/obo/UBERON_0000065

LitCovid-sample-Pubtator

Id Subject Object Predicate Lexical cue pubann:denotes
199 5880-5890 Gene denotes bradykinin Gene:3827
1992 72748-72752 Gene denotes ACE2 Gene:59272
1993 72844-72848 Gene denotes ACE2 Gene:59272
1994 72886-72896 Gene denotes collectrin Gene:57393
1080 38724-38728 Gene denotes ACE2 Gene:59272
1081 37959-37967 Species denotes SARS-CoV Tax:694009
100 2741-2754 Gene denotes angiotensin I Gene:183
101 2759-2769 Gene denotes bradykinin Gene:3827
1014 35333-35338 Gene denotes spike Gene:43740568
1015 35358-35366 Gene denotes membrane Gene:43740571
1016 35344-35352 Gene denotes envelope Gene:43740570
1017 36290-36291 Gene denotes S Gene:43740568
1018 35989-35990 Gene denotes S Gene:43740568
1019 35921-35922 Gene denotes S Gene:43740568
102 2817-2820 Gene denotes ACE Gene:1636
1020 35773-35781 Gene denotes membrane Gene:43740571
1021 35279-35290 Species denotes coronavirus Tax:11118
1022 35910-35920 Species denotes SARS-CoV-2 Tax:2697049
1023 35994-35999 Species denotes human Tax:9606
1024 36000-36008 Species denotes SARS-CoV Tax:694009
1025 36073-36083 Species denotes SARS-CoV-2 Tax:2697049
1026 36127-36135 Species denotes SARS-CoV Tax:694009
1027 36265-36273 Species denotes SARS-CoV Tax:694009
1028 36279-36289 Species denotes SARS-CoV-2 Tax:2697049
1029 36366-36374 Species denotes SARS-CoV Tax:694009
103 2921-2924 Gene denotes ACE Gene:1636
1030 36378-36388 Species denotes SARS-CoV-2 Tax:2697049
1031 35609-35625 Chemical denotes N-linked glycans
1035 36472-36483 Species denotes Coronavirus Tax:11118
1036 36551-36559 Species denotes SARS-CoV Tax:694009
1037 36564-36574 Species denotes SARS-CoV-2 Tax:2697049
104 3057-3060 Gene denotes ACE Gene:1636
1048 36803-36811 Gene denotes envelope Gene:43740570
1049 36580-36581 Gene denotes S Gene:43740568
105 2956-2978 Disease denotes cardiovascular disease MESH:D002318
1050 50421-50428 Gene denotes mmodate Gene:43740571
1051 50076-50086 Gene denotes data conve Gene:43740571
1052 37089-37097 Species denotes SARS-CoV Tax:694009
1053 38935-38945 Species denotes SARS-CoV-2 Tax:2697049
1054 36711-36713 Gene denotes aa Gene:351
1055 36672-36674 Gene denotes aa Gene:351
1056 49953-49976 Chemical denotes g et al., 2020b; Wang e MESH:D005998
1057 50002-50008 Chemical denotes alls e MESH:D000409
106 3002-3014 Disease denotes hypertension MESH:D006973
107 3019-3043 Disease denotes congestive heart failure MESH:D006333
1076 38087-38091 Gene denotes ACE2 Gene:59272
1077 38237-38241 Gene denotes ACE2 Gene:70008
1078 38427-38431 Gene denotes ACE2 Gene:59272
1079 38520-38525 Gene denotes hDPP4 Gene:1803
1082 37972-37982 Species denotes SARS-CoV-2 Tax:2697049
1083 38194-38199 Species denotes human Tax:9606
1084 38217-38220 Species denotes pig Tax:9823
1085 38230-38235 Species denotes mouse Tax:10090
1086 38394-38404 Species denotes SARS-CoV-2 Tax:2697049
1087 38408-38416 Species denotes SARS-CoV Tax:694009
1088 38484-38489 Species denotes human Tax:9606
1089 38514-38518 Species denotes CoVs Tax:11118
1090 38543-38551 Species denotes MERS CoV Tax:1335626
1091 38556-38565 Species denotes HCoV-229E Tax:11137
1092 38705-38715 Species denotes SARS-CoV-2 Tax:2697049
1093 38370-38378 Disease denotes infected MESH:D007239
1097 38817-38825 Gene denotes membrane Gene:43740571
1098 38922-38930 Species denotes SARS-CoV Tax:694009
1099 38935-38945 Species denotes SARS-CoV-2 Tax:2697049
1109 39647-39648 Gene denotes S Gene:43740568
1110 39154-39155 Gene denotes S Gene:43740568
1111 40721-40725 Gene denotes post Gene:159371
1112 40219-40223 Gene denotes post Gene:159371
1113 40592-40600 Gene denotes membrane Gene:43740571
1114 39356-39364 Gene denotes membrane Gene:43740571
1115 39006-39014 Species denotes SARS-CoV Tax:694009
1116 39019-39029 Species denotes SARS-CoV-2 Tax:2697049
1117 40418-40420 Gene denotes aa Gene:351
1127 41920-41921 Gene denotes S Gene:43740568
1128 41320-41321 Gene denotes S Gene:43740568
1129 41266-41267 Gene denotes S Gene:43740568
1130 41886-41890 Gene denotes post Gene:159371
1131 42162-42170 Gene denotes membrane Gene:43740571
1132 42124-42132 Gene denotes membrane Gene:43740571
1133 42095-42103 Gene denotes membrane Gene:43740571
1134 41694-41702 Gene denotes membrane Gene:43740571
1135 41211-41222 Species denotes Coronavirus Tax:11118
1139 42501-42504 Gene denotes PDB Gene:5131
1140 42254-42255 Gene denotes S Gene:43740568
1141 42267-42277 Species denotes SARS-CoV-2 Tax:2697049
1163 42547-42551 Gene denotes ACE2 Gene:59272
1164 43392-43397 Gene denotes furin Gene:5045
1165 43474-43481 Gene denotes TMPRSS2 Gene:7113
1166 43629-43640 Gene denotes cathepsin L Gene:1514
1167 42948-42953 Gene denotes furin Gene:5045
1168 43184-43189 Gene denotes furin Gene:5045
1169 43119-43120 Gene denotes S Gene:43740568
1170 42565-42566 Gene denotes S Gene:43740568
1171 43956-43964 Gene denotes membrane Gene:43740571
1172 43903-43911 Gene denotes membrane Gene:43740571
1173 43516-43524 Gene denotes membrane Gene:43740571
1174 42648-42658 Species denotes SARS-CoV-2 Tax:2697049
1175 42722-42732 Species denotes SARS-CoV-2 Tax:2697049
1176 42756-42764 Species denotes SARS-CoV Tax:694009
1177 42786-42799 Species denotes coronaviruses Tax:11118
1178 43108-43118 Species denotes SARS-CoV-2 Tax:2697049
1179 43252-43260 Species denotes SARS-CoV Tax:694009
1180 43286-43296 Species denotes SARS-COV-2 Tax:2697049
1181 43738-43748 Species denotes SARS-CoV-2 Tax:2697049
1182 43402-43407 Gene denotes furin Gene:5045
1183 43791-43799 Disease denotes COVID-19 MESH:C000657245
1192 44386-44393 Gene denotes TMPRSS2 Gene:487770
1193 44188-44193 Gene denotes furin Gene:5045
1194 44041-44042 Gene denotes S Gene:43740568
1195 44661-44665 Gene denotes fuse Gene:2522
1196 44682-44690 Gene denotes membrane Gene:43740571
1197 44601-44609 Gene denotes membrane Gene:43740571
1198 44448-44456 Gene denotes membrane Gene:43740571
1199 44361-44369 Gene denotes membrane Gene:43740571
1201 44914-44924 Species denotes SARS-CoV-2 Tax:2697049
1217 45521-45525 Gene denotes ACE2 Gene:59272
1218 45629-45634 Gene denotes hDPP4 Gene:1803
1219 45674-45678 Gene denotes ACE2 Gene:59272
122 3176-3180 Gene denotes ACE2 Gene:59272
1220 45732-45736 Gene denotes ACE2 Gene:59272
1221 45610-45618 Gene denotes membrane Gene:43740571
1222 44958-44968 Species denotes SARS-CoV-2 Tax:2697049
1223 44973-44981 Species denotes SARS-CoV Tax:694009
1224 45049-45059 Species denotes SARS-CoV-2 Tax:2697049
1225 45090-45098 Species denotes SARS-CoV Tax:694009
1226 45100-45108 Species denotes SARS-CoV Tax:694009
1227 45226-45236 Species denotes SARS-CoV-2 Tax:2697049
1228 45283-45291 Species denotes SARS-CoV Tax:694009
1229 45399-45409 Species denotes SARS-CoV-2 Tax:2697049
123 3283-3296 Gene denotes angiotensin I Gene:183
1230 45455-45465 Species denotes SARS-CoV-2 Tax:2697049
1231 45555-45558 CellLine denotes HEK CVCL:M624
124 3349-3352 Gene denotes ACE Gene:1636
1248 46011-46013 Gene denotes β1 Gene:597
1249 46015-46017 Gene denotes β2 Gene:170589
125 3438-3442 Gene denotes ACE2 Gene:59272
1250 46019-46021 Gene denotes β3 Gene:28883
1251 46023-46025 Gene denotes β4 Gene:28898
1252 46027-46029 Gene denotes β7 Gene:28885
1253 46082-46084 Gene denotes β4 Gene:28898
1254 46161-46164 Gene denotes β2’ Gene:170589
1255 46153-46156 Gene denotes β1’ Gene:597
1256 46141-46143 Gene denotes β6 Gene:28873
1257 46134-46136 Gene denotes β5 Gene:28884
1258 46089-46091 Gene denotes β7 Gene:28885
1259 45786-45796 Species denotes SARS-CoV-2 Tax:2697049
126 3476-3480 Gene denotes ACE2 Gene:59272
1260 45893-45903 Species denotes SARS-CoV-2 Tax:2697049
1261 46323-46333 Species denotes SARS-COV-2 Tax:2697049
1262 46338-46346 Species denotes SARS-CoV Tax:694009
1263 46203-46212 Chemical denotes disulfide MESH:D004220
127 3534-3537 Gene denotes ACE Gene:1636
1271 46608-46612 Gene denotes ACE2 Gene:59272
1272 46679-46684 Gene denotes hACE2 Gene:59272
1273 46567-46572 Gene denotes spike Gene:43740568
1274 46911-46914 Gene denotes PDB Gene:5131
1275 46869-46872 Gene denotes PDB Gene:5131
1276 46323-46333 Species denotes SARS-COV-2 Tax:2697049
1277 46710-46720 Species denotes SARS-CoV-2 Tax:2697049
128 3573-3577 Gene denotes ACE2 Gene:59272
129 3732-3736 Gene denotes ACE2 Gene:59272
130 3873-3877 Gene denotes ACE2 Gene:59272
1301 46996-47000 Gene denotes ACE2 Gene:59272
1302 47315-47319 Gene denotes ACE2 Gene:59272
1303 47584-47588 Gene denotes ACE2 Gene:59272
1304 47816-47820 Gene denotes ACE2 Gene:59272
1305 47975-47979 Gene denotes ACE2 Gene:59272
1306 48498-48502 Gene denotes ACE2 Gene:59272
1307 48077-48078 Gene denotes S Gene:43740568
1308 48023-48024 Gene denotes S Gene:43740568
1309 47171-47172 Gene denotes S Gene:43740568
131 3723-3731 Gene denotes membrane Gene:43740571
1310 46976-46986 Species denotes SARS-CoV-2 Tax:2697049
1311 47073-47083 Species denotes SARS-CoV-2 Tax:2697049
1312 47544-47554 Species denotes SARS-CoV-2 Tax:2697049
1313 47613-47621 Species denotes SARS-CoV Tax:694009
1314 47793-47803 Species denotes SARS-CoV-2 Tax:2697049
1315 47841-47851 Species denotes SARS-CoV-2 Tax:2697049
1316 47875-47883 Species denotes SARS-CoV Tax:694009
1317 48012-48022 Species denotes SARS-CoV-2 Tax:2697049
1318 48139-48149 Species denotes SARS-CoV-2 Tax:2697049
1319 48208-48216 Species denotes SARS-CoV Tax:694009
132 3636-3644 Species denotes SARS-CoV Tax:694009
1320 48386-48396 Species denotes SARS-CoV-2 Tax:2697049
1321 48401-48409 Species denotes SARS-CoV Tax:694009
1322 48445-48455 Species denotes SARS-CoV-2 Tax:2697049
1323 48758-48768 Species denotes SARS-CoV-2 Tax:2697049
1329 48836-48841 Gene denotes spike Gene:43740568
133 3771-3781 Species denotes SARS-CoV-2 Tax:2697049
1330 48843-48844 Gene denotes S Gene:43740568
1331 48879-48883 Gene denotes ACE2 Gene:59272
1332 48858-48859 Gene denotes S Gene:43740568
1333 48825-48835 Species denotes SARS-CoV-2 Tax:2697049
134 3142-3145 Gene denotes ACE Gene:11421
1344 48970-48971 Gene denotes S Gene:43740568
1345 48930-48931 Gene denotes S Gene:43740568
1346 48923-48929 Species denotes SARS-2 Tax:2697049
1347 48963-48969 Species denotes SARS-2 Tax:2697049
1348 49001-49007 Species denotes SARS-2 Tax:2697049
1349 49051-49057 Species denotes SARS-2 Tax:2697049
135 3823-3831 Disease denotes COVID-19 MESH:C000657245
1350 49104-49110 Species denotes SARS-2 Tax:2697049
1351 49202-49208 Species denotes SARS-2 Tax:2697049
1352 49269-49275 Species denotes SARS-2 Tax:2697049
1353 49154-49175 CellLine denotes SARS-2 S319–529 44.2 CVCL:Z232
1355 49353-49357 Gene denotes ACE2 Gene:59272
1360 49442-49446 Gene denotes ACE2 Gene:59272
1361 49623-49627 Gene denotes ACE2 Gene:59272
1362 49512-49520 Species denotes SARS-CoV Tax:694009
1363 49636-49644 Species denotes SARS-CoV Tax:694009
1404 49886-49890 Gene denotes ACE2 Gene:59272
1405 50342-50346 Gene denotes ACE2 Gene:59272
1406 50407-50411 Gene denotes ACE2 Gene:59272
1407 50560-50564 Gene denotes ACE2 Gene:59272
1408 50582-50586 Gene denotes ACE2 Gene:59272
1409 50781-50785 Gene denotes ACE2 Gene:59272
1410 51223-51225 Gene denotes β5 Gene:28884
1411 51379-51383 Gene denotes ACE2 Gene:59272
1412 51579-51583 Gene denotes ACE2 Gene:59272
1413 51823-51827 Gene denotes ACE2 Gene:59272
1414 51909-51913 Gene denotes ACE2 Gene:59272
1415 52025-52029 Gene denotes ACE2 Gene:59272
1416 52192-52196 Gene denotes ACE2 Gene:59272
1417 52388-52392 Gene denotes ACE2 Gene:59272
1418 50707-50708 Gene denotes S Gene:43740568
1419 50434-50435 Gene denotes S Gene:43740568
1420 50308-50309 Gene denotes S Gene:43740568
1421 50203-50204 Gene denotes S Gene:43740568
1422 50906-50908 Gene denotes β6 Gene:28873
1423 50899-50901 Gene denotes β5 Gene:28884
1424 49815-49825 Species denotes SARS-CoV-2 Tax:2697049
1425 49891-49901 Species denotes SARS-CoV-2 Tax:2697049
1426 50565-50573 Species denotes SARS-CoV Tax:694009
1427 50587-50597 Species denotes SARS-CoV-2 Tax:2697049
1428 50662-50672 Species denotes SARS-CoV-2 Tax:2697049
1429 50732-50740 Species denotes SARS-CoV Tax:694009
1430 51333-51343 Species denotes SARS-CoV-2 Tax:2697049
1431 51348-51356 Species denotes SARS-CoV Tax:694009
1432 51385-51393 Species denotes SARS-CoV Tax:694009
1433 51472-51482 Species denotes SARS-CoV-2 Tax:2697049
1434 51664-51674 Species denotes SARS-CoV-2 Tax:2697049
1435 52041-52051 Species denotes SARS-CoV-2 Tax:2697049
1436 52177-52187 Species denotes SARS-CoV-2 Tax:2697049
1437 51415-51426 Chemical denotes Pro-Pro-Ala MESH:C027789
1438 51453-51468 Chemical denotes Gly-Val-Glu-Gly
1439 51600-51605 Chemical denotes Ser19
144 4128-4132 Gene denotes ACE2 Gene:59272
1440 51610-51615 Chemical denotes Gln24
1441 51654-51660 Chemical denotes Phe486
1442 51814-51819 Chemical denotes Tyr83
1443 51849-51855 Chemical denotes Asn501
145 4248-4252 Gene denotes ACE2 Gene:59272
1454 52456-52468 Gene denotes RBD-receptor
1455 52810-52814 Gene denotes ACE2 Gene:480847
1456 52986-52990 Gene denotes ACE2 Gene:59272
1457 52984-52985 Gene denotes S Gene:43740568
1458 52867-52868 Gene denotes S Gene:43740568
1459 52790-52794 Species denotes cats Tax:9685
146 4268-4272 Gene denotes ACE2 Gene:59272
1460 52799-52803 Species denotes dogs Tax:9615
1461 52856-52866 Species denotes SARS-CoV-2 Tax:2697049
1462 52891-52899 Disease denotes COVID-19 MESH:C000657245
1463 52900-52909 Disease denotes infection MESH:D007239
147 4290-4300 Species denotes SARS-CoV-2 Tax:2697049
148 3953-3965 Disease denotes Hypertension MESH:D006973
1484 53094-53098 Gene denotes ACE2 Gene:59272
1485 53383-53386 Gene denotes ACE Gene:1636
1486 53533-53537 Gene denotes ACE2 Gene:59272
1487 53723-53727 Gene denotes ACE2 Gene:59272
1488 53783-53787 Gene denotes ACE2 Gene:59272
1489 53837-53841 Gene denotes ACE2 Gene:59272
149 4011-4019 Disease denotes COVID-19 MESH:C000657245
1490 53039-53044 Species denotes human Tax:9606
1491 53045-53048 Species denotes CoV Tax:11118
1492 53050-53059 Species denotes hCoV-NL63 Tax:277944
1493 53206-53216 Species denotes SARS-CoV-2 Tax:2697049
1494 53262-53271 Species denotes hCoV-NL63 Tax:277944
1496 53445-53455 Species denotes SARS-CoV-2 Tax:2697049
1497 53480-53484 Species denotes CoVs Tax:11118
1498 53622-53631 Species denotes novel CoV Tax:2697049
1499 53647-53653 Species denotes humans Tax:9606
150 4085-4097 Disease denotes hypertension MESH:D006973
1500 53713-53717 Species denotes CoVs Tax:11118
1501 53773-53776 Species denotes CoV Tax:11118
1502 53880-53890 Species denotes SARS-CoV-2 Tax:2697049
1503 53951-53954 Species denotes CoV Tax:11118
1505 54005-54009 Gene denotes ACE2 Gene:59272
151 4104-4116 Disease denotes hypertensive MESH:D006973
153 4452-4456 Gene denotes ACE2 Gene:59272
1536 54078-54086 Species denotes patients Tax:9606
1537 54536-54544 Species denotes patients Tax:9606
1538 55204-55212 Species denotes patients Tax:9606
1539 55944-55952 Species denotes patients Tax:9606
1540 55983-55993 Species denotes SARS-CoV-2 Tax:2697049
1541 54069-54077 Disease denotes COVID-19 MESH:C000657245
1542 54194-54206 Disease denotes hypertension MESH:D006973
1543 54208-54231 Disease denotes cardiovascular diseases MESH:D002318
1544 54236-54260 Disease denotes type-2 diabetes mellitus MESH:D003924
1545 54527-54535 Disease denotes infected MESH:D007239
1546 54618-54630 Disease denotes hypertension MESH:D006973
1547 54640-54648 Disease denotes diabetes MESH:D003920
1548 54661-54684 Disease denotes cardiovascular diseases MESH:D002318
1549 54834-54846 Disease denotes hypertension MESH:D006973
1550 54856-54878 Disease denotes cardiovascular disease MESH:D002318
1551 55046-55054 Disease denotes COVID-19 MESH:C000657245
1552 55268-55280 Disease denotes hypertension MESH:D006973
1553 55285-55294 Disease denotes mortality MESH:D003643
1554 55382-55394 Disease denotes hypertension MESH:D006973
1555 55402-55410 Disease denotes diabetes MESH:D003920
1556 55422-55444 Disease denotes cardiovascular disease MESH:D002318
1557 55477-55485 Disease denotes Diabetes MESH:D003920
1558 55533-55537 Disease denotes ARDS MESH:D012128
1559 55551-55570 Disease denotes acute kidney injury MESH:D058186
156 4655-4658 Gene denotes ACE Gene:1636
1560 55584-55596 Disease denotes septic shock MESH:D012772
1561 55624-55633 Disease denotes mortality MESH:D003643
1562 55795-55804 Disease denotes mortality MESH:D003643
1563 55888-55896 Disease denotes COVID-19 MESH:C000657245
1564 55915-55922 Disease denotes obesity MESH:D009765
1565 56126-56135 Disease denotes mortality MESH:D003643
157 4670-4674 Gene denotes ACE2 Gene:59272
1571 56395-56399 Gene denotes ACE2 Gene:59272
1572 56556-56560 Gene denotes ACE2 Gene:59272
1573 56690-56700 Species denotes SARS-CoV-2 Tax:2697049
1574 56226-56238 Disease denotes hypertensive MESH:D006973
1575 56598-56616 Disease denotes SARS-CoV infection MESH:C000657245
1581 57665-57668 Gene denotes ACE Gene:1636
1582 56786-56796 Species denotes SARS-CoV-2 Tax:2697049
1583 57716-57724 Species denotes patients Tax:9606
1584 57735-57747 Disease denotes hypertension MESH:D006973
1585 57772-57793 Disease denotes coronavirus infection MESH:D018352
1595 58004-58008 Gene denotes ACE2 Gene:59272
1596 58063-58067 Gene denotes ACE2 Gene:59272
1597 58070-58074 Gene denotes ACE2 Gene:59272
1598 58221-58225 Gene denotes ACE2 Gene:59272
1599 58281-58291 Species denotes SARS-CoV-2 Tax:2697049
1600 57922-57937 Disease denotes viral infection MESH:D001102
1601 58158-58170 Disease denotes hypertension MESH:D006973
1602 58172-58194 Disease denotes cardiovascular disease MESH:D002318
1603 58199-58207 Disease denotes diabetes MESH:D003920
1611 58479-58483 Gene denotes ACE2 Gene:59272
1612 58650-58654 Gene denotes ACE2 Gene:59272
1613 58771-58775 Gene denotes ACE2 Gene:59272
1614 58500-58508 Gene denotes membrane Gene:43740571
1615 58525-58545 Disease denotes SARS-CoV-2 infection MESH:C000657245
1616 58706-58715 Disease denotes infection MESH:D007239
1617 58814-58834 Disease denotes respiratory distress MESH:D012128
1622 59181-59189 Species denotes patients Tax:9606
1623 59195-59203 Disease denotes COVID-19 MESH:C000657245
1624 59208-59220 Disease denotes hypertension MESH:D006973
1625 59309-59318 Disease denotes mortality MESH:D003643
1630 59582-59590 Species denotes patients Tax:9606
1631 59700-59708 Species denotes patients Tax:9606
1632 59596-59604 Disease denotes COVID-19 MESH:C000657245
1633 59714-59722 Disease denotes COVID-19 MESH:C000657245
1645 60004-60008 Gene denotes ACE2 Gene:59272
1646 60033-60037 Gene denotes ACE2 Gene:59272
1647 60166-60170 Gene denotes ACE2 Gene:59272
1648 60205-60209 Gene denotes SIT1 Gene:27240
1649 59961-59966 Species denotes human Tax:9606
1650 60095-60100 Species denotes human Tax:9606
1651 60101-60109 Species denotes patients Tax:9606
1652 60184-60192 Gene denotes membrane Gene:43740571
1653 59937-59957 Disease denotes SARS-CoV-2 infection MESH:C000657245
1654 60247-60255 Disease denotes COVID-19 MESH:C000657245
1655 60295-60307 Disease denotes hypertensive MESH:D006973
1657 60318-60322 Gene denotes ACE2 Gene:59272
167 4691-4720 Gene denotes Angiotensin-converting enzyme Gene:1636
1673 60633-60641 Species denotes patients Tax:9606
1674 61230-61238 Species denotes patients Tax:9606
1675 60399-60415 Disease denotes viral infections MESH:D001102
1676 60417-60424 Disease denotes COVID19 MESH:C000657245
1677 60552-60556 Disease denotes ARDS MESH:D012128
1678 60574-60585 Disease denotes lung injury MESH:D055370
1679 60688-60692 Disease denotes ARDS MESH:D012128
168 4722-4725 Gene denotes ACE Gene:1636
1680 60758-60766 Disease denotes COVID-19 MESH:C000657245
1681 60812-60821 Disease denotes pneumonia MESH:D011014
1682 60851-60871 Disease denotes microvascular damage MESH:D017566
1683 61020-61046 Disease denotes cardiovascular involvement MESH:D002318
1684 61090-61107 Disease denotes myocardial injury MESH:D009202
1685 61112-61124 Disease denotes sudden death MESH:D003645
1686 61154-61163 Disease denotes infection MESH:D007239
1687 61221-61229 Disease denotes COVID-19 MESH:C000657245
169 4897-4900 Gene denotes ACE Gene:1636
170 4902-4906 Gene denotes tACE Gene:6868
1703 61778-61783 Gene denotes IL-1β Gene:3552
1704 61785-61790 Gene denotes IFN-γ Gene:3458
1705 61792-61797 Gene denotes IP-10 Gene:3627
1706 61799-61804 Gene denotes MCP-1 Gene:6347
1707 61806-61810 Gene denotes IL-4 Gene:3565
1708 61816-61821 Gene denotes IL-10 Gene:3586
1709 61530-61538 Species denotes patients Tax:9606
171 5050-5053 Gene denotes ACE Gene:1636
1710 61644-61652 Species denotes patients Tax:9606
1711 61730-61738 Species denotes patients Tax:9606
1712 61842-61848 Species denotes people Tax:9606
1713 61864-61872 Species denotes patients Tax:9606
1714 61475-61484 Disease denotes infection MESH:D007239
1715 61601-61609 Disease denotes COVID-19 MESH:C000657245
1716 61614-61623 Disease denotes pneumonia MESH:D011014
1717 61653-61657 Disease denotes ARDS MESH:D012128
172 4873-4876 Gene denotes ACE Gene:1636
1725 62238-62242 Gene denotes ACE2 Gene:59272
1726 62326-62330 Gene denotes ACE2 Gene:59272
1727 63174-63179 Gene denotes NLRP3 Gene:114548
1728 63342-63351 Gene denotes caspase 1 Gene:834
1729 63116-63124 Gene denotes membrane Gene:43740571
173 5003-5011 Gene denotes membrane Gene:43740571
1730 62720-62732 Disease denotes inflammation MESH:D007249
1731 63460-63472 Disease denotes inflammation MESH:D007249
1734 63599-63603 Gene denotes ACE2 Gene:59272
1735 63668-63678 Species denotes SARS-CoV-2 Tax:2697049
174 4685-4690 Species denotes Human Tax:9606
1746 63804-63809 Gene denotes NLRP3 Gene:114548
1747 63875-63891 Gene denotes IL-1β (Chen et a Gene:3552
1748 64010-64030 Gene denotes IL-1β (Huang C. et a Gene:3552
1749 63914-63922 Species denotes patients Tax:9606
175 4745-4754 Chemical denotes gluzincin
1750 63687-63707 Disease denotes SARS-CoV-2 infection MESH:C000657245
1751 63905-63913 Disease denotes COVID-19 MESH:C000657245
1752 64062-64073 Disease denotes leucopoenia
1753 64078-64089 Disease denotes lymphopenia MESH:D008231
1754 64110-64128 Disease denotes COVID-19 pneumonia MESH:C000657245
1755 64183-64214 Disease denotes lymphocyte injury by pyroptosis MESH:D015451
1771 64316-64319 Gene denotes ACE Gene:1636
1772 64320-64324 Gene denotes ACE2 Gene:59272
1773 64388-64392 Gene denotes ACE2 Gene:59272
1774 64663-64667 Gene denotes AT1R Gene:185
1775 64721-64728 Gene denotes ADAM 17 Gene:6868
1776 64744-64748 Gene denotes TNFα Gene:7124
1777 64765-64769 Gene denotes TACE Gene:6868
1778 64851-64855 Gene denotes EGFR Gene:1956
1779 64861-64865 Gene denotes TNFα Gene:7124
1780 65011-65018 Gene denotes ADAM 17 Gene:6868
1781 65076-65082 Gene denotes IL-6Rα Gene:3570
1782 65094-65098 Gene denotes IL-6 Gene:3569
1783 65099-65104 Gene denotes STAT3 Gene:6774
1784 65413-65428 Gene denotes angiotensinogen Gene:183
1785 64302-64312 Species denotes SARS-CoV-2 Tax:2697049
1803 65531-65535 Gene denotes ACE2 Gene:59272
1804 65620-65624 Gene denotes ACE2 Gene:59272
1805 65750-65754 Gene denotes ACE2 Gene:59272
1806 65874-65881 Gene denotes ADAM 17 Gene:6868
1807 65924-65928 Gene denotes TNFα Gene:7124
1808 65988-65992 Gene denotes ACE2 Gene:59272
1809 66166-66170 Gene denotes ACE2 Gene:59272
1810 66401-66405 Gene denotes ACE2 Gene:59272
1811 66474-66480 Gene denotes ADAM17 Gene:6868
1812 66111-66116 Species denotes human Tax:9606
1813 66160-66165 Species denotes human Tax:9606
1814 65951-65959 Gene denotes membrane Gene:43740571
1815 66200-66225 Chemical denotes phorbol myristate acetate MESH:D013755
1816 65588-65600 Disease denotes inflammation MESH:D007249
1817 66117-66133 Disease denotes embryonic kidney MESH:D007674
1818 66141-66147 CellLine denotes HEK293 CVCL:0045
1819 66172-66180 CellLine denotes HEK-ACE2 CVCL:L310
1829 66628-66632 Gene denotes ACE2 Gene:59272
1830 66774-66778 Gene denotes ACE2 Gene:59272
1831 66916-66921 Gene denotes IL-1β Gene:3552
1832 66977-66981 Gene denotes ACE2 Gene:59272
1833 67144-67148 Gene denotes ACE2 Gene:59272
1834 67226-67232 Gene denotes ADAM17 Gene:6868
1835 67297-67307 Species denotes SARS-CoV-2 Tax:2697049
1836 66705-66720 Disease denotes viral infection MESH:D001102
1837 67188-67203 Disease denotes viral infection MESH:D001102
1849 67465-67475 Species denotes SARS-CoV-2 Tax:2697049
1850 67853-67863 Species denotes SARS-CoV-2 Tax:2697049
1851 67896-67906 Species denotes SARS-CoV-2 Tax:2697049
1852 68269-68279 Species denotes SARS-CoV-2 Tax:2697049
1853 67491-67500 Chemical denotes vitamin D MESH:D014807
1854 67625-67640 Disease denotes hypovitaminosis
1855 67668-67676 Disease denotes COVID-19 MESH:C000657245
1856 67988-68003 Disease denotes hypovitaminosis
1857 68010-68030 Disease denotes pulmonary infections MESH:D012141
1858 68087-68109 Disease denotes respiratory infections MESH:D012141
1859 68294-68303 Disease denotes mortality MESH:D003643
1861 68370-68374 Gene denotes ACE2 Gene:59272
1868 68422-68426 Gene denotes ACE2 Gene:59272
1869 68599-68603 Gene denotes ACE2 Gene:59272
1870 68528-68538 Species denotes SARS-CoV-2 Tax:2697049
1871 68468-68476 Disease denotes COVID-19 MESH:C000657245
1872 68613-68622 Disease denotes infection MESH:D007239
1873 68780-68791 Disease denotes lung injury MESH:D055370
1880 68934-68938 Gene denotes ACE2 Gene:59272
1881 69013-69018 Gene denotes ACE 2 Gene:59272
1882 69074-69078 Gene denotes ACE2 Gene:59272
1883 69120-69129 Gene denotes S-protein Gene:43740568
1884 69007-69012 Species denotes human Tax:9606
1885 68948-68957 Disease denotes infection MESH:D007239
1887 69168-69172 Gene denotes ACE2 Gene:59272
1889 69215-69219 Gene denotes ACE2 Gene:59272
1891 69222-69226 Gene denotes ACE2 Gene:59272
1907 69248-69252 Gene denotes ACE2 Gene:59272
1908 69772-69776 Gene denotes ACE2 Gene:59272
1909 70024-70028 Gene denotes ACE2 Gene:59272
191 5170-5173 Gene denotes ACE Gene:1636
1910 70130-70134 Gene denotes ACE2 Gene:59272
1911 70240-70244 Gene denotes ACE2 Gene:59272
1912 70429-70433 Gene denotes ACE2 Gene:59272
1913 69633-69641 Species denotes SARS-CoV Tax:694009
1914 69855-69863 Species denotes SARS-CoV Tax:694009
1915 70313-70329 Species denotes SARS coronavirus Tax:694009
1916 70065-70074 Gene denotes S-protein Gene:43740568
1917 69720-69758 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine
1918 69760-69764 Chemical denotes NAAE
1919 70091-70095 Chemical denotes NAAE
192 5418-5421 Gene denotes ACE Gene:1636
1920 70276-70293 Disease denotes acute lung injury MESH:D055371
1921 70297-70307 Disease denotes infections MESH:D007239
193 5547-5560 Gene denotes angiotensin I Gene:183
1932 70590-70594 Gene denotes ACE2 Gene:59272
1933 70654-70658 Gene denotes ACE2 Gene:59272
1934 70805-70809 Gene denotes ACE2 Gene:59272
1935 71031-71062 Gene denotes angiotensin-converting enzyme 2 Gene:59272
1936 70708-70718 Species denotes SARS-CoV-2 Tax:2697049
1937 71025-71030 Species denotes human Tax:9606
1938 71075-71083 Species denotes patients Tax:9606
1939 71064-71070 Chemical denotes rhACE2
194 5565-5575 Gene denotes bradykinin Gene:3827
1940 70903-70914 Disease denotes lung injury MESH:D055370
1941 71089-71097 Disease denotes COVID-19 MESH:C000657245
195 5611-5614 Gene denotes ACE Gene:1636
1959 69013-69018 Gene denotes ACE 2 Gene:59272
196 5708-5721 Gene denotes angiotensin I Gene:183
1960 71241-71250 Gene denotes S-protein Gene:43740568
1961 71943-71948 Gene denotes hACE2 Gene:59272
1962 72096-72100 Gene denotes ACE2 Gene:59272
1963 72210-72214 Gene denotes ACE2 Gene:59272
1964 69007-69012 Species denotes human Tax:9606
1965 71404-71412 Species denotes patients Tax:9606
1966 71644-71652 Species denotes patients Tax:9606
2111 75936-75940 Gene denotes ACE2 Gene:59272
2114 76109-76113 Gene denotes ACE2 Gene:59272
1967 71811-71816 Species denotes human Tax:9606
1968 71844-71849 Species denotes human Tax:9606
1969 72005-72015 Species denotes SARS-CoV-2 Tax:2697049
197 5734-5748 Gene denotes angiotensin II Gene:183
1970 72112-72122 Species denotes SARS-CoV-2 Tax:2697049
1971 71538-71544 Chemical denotes rhACE2
1972 71724-71730 Chemical denotes rhACE2
1973 71395-71403 Disease denotes COVID-19 MESH:C000657245
1974 71658-71662 Disease denotes ARDS MESH:D012128
1975 71775-71796 Disease denotes SARS-CoV-2 infections MESH:C000657245
1979 72294-72298 Gene denotes ACE2 Gene:59272
198 5834-5837 Gene denotes ACE Gene:1636
1980 72641-72645 Gene denotes ACE2 Gene:59272
1981 72597-72612 Disease denotes viral infection MESH:D001102
1983 15600-15604 Gene denotes ACE2 Gene:59272
1995 72955-72962 Gene denotes insulin Gene:3630
1996 73009-73013 Gene denotes ACE2 Gene:59272
1997 73115-73119 Gene denotes ACE2 Gene:59272
1998 73184-73198 Species denotes gut microbiome Tax:749906
1999 73040-73057 Disease denotes Hartnup’s disease MESH:D006250
2 0-4 Gene denotes ACE2 Gene:59272
200 5956-5959 Gene denotes ACE Gene:1636
2007 73235-73239 Gene denotes ACE2 Gene:59272
2008 73358-73362 Gene denotes ACE2 Gene:59272
2009 73363-73367 Gene denotes Ang1 Gene:284
201 5261-5284 Chemical denotes angiotensin-aldosterone
2010 73392-73399 Gene denotes insulin Gene:3630
2011 73479-73483 Gene denotes ACE2 Gene:59272
2012 73370-73374 Gene denotes MasR Gene:116511
2013 73302-73321 Disease denotes glucose homeostasis MESH:D044882
2017 73629-73633 Gene denotes ACE2 Gene:59272
2018 73697-73701 Gene denotes ACE2 Gene:59272
2019 73649-73666 Disease denotes Alzheimer disease MESH:D000544
202 5286-5290 Chemical denotes RAAS
203 6023-6027 Chemical denotes salt MESH:D012492
2038 73848-73852 Gene denotes ACE2 Gene:59272
2039 74136-74140 Gene denotes ACE2 Gene:59272
204 5306-5329 Disease denotes cardiovascular diseases MESH:D002318
2040 74203-74207 Gene denotes ACE2 Gene:59272
2041 74318-74322 Gene denotes ACE2 Gene:70008
2042 74489-74493 Gene denotes ACE2 Gene:70008
2043 74521-74531 Gene denotes E-cadherin Gene:999
2044 74575-74583 Gene denotes vimentin Gene:7431
2045 74105-74113 Species denotes patients Tax:9606
2046 74270-74275 Species denotes human Tax:9606
2047 74290-74294 Species denotes mice Tax:10090
2048 73840-73846 Disease denotes cancer MESH:D009369
2049 73874-73880 Disease denotes cancer MESH:D009369
205 5915-5926 Disease denotes hypotensive MESH:D007022
2051 74080-74104 Disease denotes hepatocellular carcinoma MESH:D006528
2052 74333-74338 Disease denotes tumor MESH:D009369
2053 74390-74416 Disease denotes Non-Small Cell Lung Cancer MESH:D002289
2054 74418-74423 Disease denotes NSCLC MESH:D002289
2055 74647-74652 Disease denotes NSCLC MESH:D002289
2062 74890-74894 Gene denotes ACE2 Gene:59272
2063 74731-74739 Species denotes patients Tax:9606
2064 74719-74730 Disease denotes lung cancer MESH:D008175
2065 74752-74760 Disease denotes COVID-19 MESH:C000657245
2066 74873-74885 Disease denotes malignancies MESH:D009369
2067 74982-74988 Disease denotes cancer MESH:D009369
2071 75060-75064 Gene denotes ACE2 Gene:59272
2072 75147-75151 Gene denotes ACE2 Gene:59272
2073 75086-75092 Disease denotes cancer MESH:D009369
2084 75205-75209 Gene denotes ACE2 Gene:59272
2085 75472-75476 Gene denotes ACE2 Gene:59272
2086 75247-75253 Disease denotes tumors MESH:D009369
2087 75255-75275 Disease denotes colon adenocarcinoma MESH:D003110
2088 75284-75321 Disease denotes kidney renal papillary cell carcinoma MESH:C538614
2089 75330-75355 Disease denotes pancreatic adenocarcinoma MESH:D000230
2090 75364-75385 Disease denotes rectum adenocarcinoma MESH:D012004
2091 75394-75416 Disease denotes stomach adenocarcinoma MESH:D000230
2092 75429-75448 Disease denotes lung adenocarcinoma MESH:D000077192
2093 75508-75536 Disease denotes lung squamous cell carcinoma MESH:D002294
2099 75550-75554 Gene denotes ACE2 Gene:59272
2100 75596-75602 Disease denotes tumors MESH:D009369
2101 75633-75650 Disease denotes thyroid carcinoma MESH:D013964
2102 75663-75681 Disease denotes kidney chromophobe MESH:D000238
2103 75683-75687 Disease denotes KICH
2106 75706-75710 Gene denotes ACE2 Gene:59272
2107 75791-75795 Gene denotes ACE2 Gene:59272
2110 75877-75881 Gene denotes ACE2 Gene:59272
2115 76128-76135 Species denotes patient Tax:9606
2122 76243-76247 Gene denotes ACE2 Gene:59272
2123 76428-76432 Gene denotes ACE2 Gene:59272
2124 76566-76570 Gene denotes ACE2 Gene:59272
2125 76339-76347 Chemical denotes Oncomine
2126 76411-76416 Disease denotes tumor MESH:D009369
2127 76531-76552 Disease denotes endometrial carcinoma MESH:D016889
2135 76683-76687 Gene denotes ACE2 Gene:59272
2136 76710-76713 Gene denotes ACE Gene:1636
2137 76753-76756 Gene denotes ACE Gene:1636
2138 76906-76910 Gene denotes ACE2 Gene:59272
2139 77070-77073 Gene denotes ACE Gene:1636
2140 77164-77168 Gene denotes ACE2 Gene:59272
2141 77010-77036 Disease denotes cardiovascular homeostasis MESH:D002318
2154 77376-77380 Gene denotes ACE2 Gene:59272
2155 77631-77635 Gene denotes ACE2 Gene:59272
2156 77784-77788 Gene denotes ACE2 Gene:59272
2157 77817-77821 Gene denotes ACE2 Gene:59272
2158 77981-77985 Gene denotes ACE2 Gene:59272
2159 78143-78147 Gene denotes ACE2 Gene:59272
2160 77457-77465 Species denotes SARS-Cov Tax:694009
2161 77470-77479 Species denotes SARS-Cov2 Tax:2697049
2162 77689-77702 Species denotes coronaviruses Tax:11118
2163 77350-77358 Disease denotes COVID-19 MESH:C000657245
2164 77907-77915 Disease denotes COVID-19 MESH:C000657245
2165 78152-78160 Disease denotes COVID-19 MESH:C000657245
2167 78312-78314 Disease denotes FS MESH:D018223
228 6078-6081 Gene denotes ACE Gene:1636
229 6357-6360 Gene denotes ACE Gene:1636
230 6516-6519 Gene denotes ACE Gene:1636
231 6728-6731 Gene denotes ACE Gene:1636
232 7056-7059 Gene denotes ACE Gene:1636
233 7075-7079 Gene denotes ACE2 Gene:59272
234 7252-7256 Gene denotes ACE2 Gene:59272
235 7329-7332 Gene denotes ACE Gene:1636
236 7360-7363 Gene denotes ACE Gene:1636
237 7365-7369 Gene denotes ACE2 Gene:59272
238 7436-7440 Gene denotes ACE2 Gene:59272
239 7525-7529 Gene denotes ACE2 Gene:59272
240 7606-7610 Gene denotes ACE2 Gene:59272
241 6148-6153 Species denotes human Tax:9606
242 6351-6356 Species denotes human Tax:9606
243 6620-6625 Species denotes human Tax:9606
244 7045-7050 Species denotes human Tax:9606
245 7206-7211 Species denotes woman Tax:9606
246 6793-6802 Chemical denotes glutamate MESH:D018698
247 6626-6634 Disease denotes lymphoma MESH:D008223
248 7014-7027 Disease denotes heart failure MESH:D006333
249 7217-7250 Disease denotes idiopathic dilated cardiomyopathy MESH:C536277
251 7723-7727 Gene denotes ACE2 Gene:59272
260 7805-7809 Gene denotes ACE2 Gene:59272
261 7884-7887 Gene denotes ACE Gene:1636
262 7943-7947 Gene denotes ACE2 Gene:59272
263 7974-7977 Gene denotes ACE Gene:1636
264 7989-7993 Gene denotes ACE2 Gene:59272
265 8063-8067 Gene denotes ACE2 Gene:59272
266 8168-8180 Disease denotes hypertension MESH:D006973
267 8185-8207 Disease denotes cardiovascular disease MESH:D002318
282 8279-8283 Gene denotes ACE2 Gene:59272
283 8428-8431 Gene denotes ACE Gene:1636
284 8436-8440 Gene denotes ACE2 Gene:59272
285 8513-8516 Gene denotes ACE Gene:1636
286 8538-8542 Gene denotes ACE2 Gene:59272
287 8608-8612 Gene denotes ACE2 Gene:59272
288 8643-8656 Gene denotes angiotensin I Gene:183
289 8660-8674 Gene denotes angiotensin II Gene:183
290 8695-8705 Gene denotes bradykinin Gene:3827
291 8717-8721 Gene denotes ACE2 Gene:59272
292 8740-8743 Gene denotes ACE Gene:1636
293 8744-8754 Chemical denotes inhibitors
294 8761-8771 Chemical denotes lisinopril MESH:D017706
295 8776-8785 Chemical denotes captopril MESH:D002216
3 19-29 Species denotes SARS-CoV-2 Tax:2697049
310 9026-9030 Gene denotes ACE2 Gene:59272
311 9119-9123 Gene denotes ACE2 Gene:59272
312 9275-9279 Gene denotes ACE2 Gene:59272
313 9711-9714 Gene denotes ACE Gene:1636
314 9719-9723 Gene denotes ACE2 Gene:59272
315 9825-9829 Gene denotes ACE2 Gene:59272
316 9922-9925 Gene denotes ACE Gene:1636
317 9956-9960 Gene denotes ACE2 Gene:59272
318 10078-10082 Gene denotes ACE2 Gene:59272
319 10175-10185 Gene denotes collectrin Gene:57393
320 10143-10146 Gene denotes ACE Gene:1636
321 10261-10269 Gene denotes membrane Gene:43740571
322 9912-9918 Chemical denotes Gln281
323 9946-9952 Chemical denotes Arg273
327 10322-10326 Gene denotes ACE2 Gene:59272
328 10671-10674 Gene denotes PDB Gene:5131
329 10379-10389 Gene denotes collectrin Gene:57393
332 10728-10732 Gene denotes Post Gene:159371
333 10702-10706 Gene denotes Post Gene:159371
337 10786-10790 Gene denotes ACE2 Gene:59272
338 10849-10853 Gene denotes ACE2 Gene:59272
339 11133-11137 Gene denotes ACE2 Gene:59272
369 11531-11535 Gene denotes ACE2 Gene:59272
370 11643-11647 Gene denotes ACE2 Gene:59272
371 11781-11785 Gene denotes ACE2 Gene:59272
372 11901-11905 Gene denotes ACE2 Gene:59272
373 11960-11964 Gene denotes ACE2 Gene:59272
374 12054-12058 Gene denotes ACE2 Gene:59272
375 12159-12162 Gene denotes ACE Gene:1636
376 12202-12207 Gene denotes renin Gene:5972
377 12404-12408 Gene denotes ACE2 Gene:59272
378 12432-12435 Gene denotes ACE Gene:1636
379 12501-12528 Gene denotes ERα) (Bukowska et al., 2017 Gene:2099
380 12814-12845 Gene denotes Estrogen Related Receptor alpha Gene:2101
381 12847-12851 Gene denotes ERRα Gene:2101
382 12869-12872 Gene denotes ERα Gene:2099
383 12940-12944 Gene denotes ACE2 Gene:59272
384 13108-13112 Gene denotes ACE2 Gene:59272
385 11351-11356 Species denotes human Tax:9606
386 12091-12096 Species denotes human Tax:9606
387 12538-12541 Gene denotes ERα Gene:2099
388 11460-11473 Chemical denotes 17β-estradiol MESH:D004958
389 11475-11477 Chemical denotes E2 MESH:D004958
390 11501-11508 Chemical denotes steroid MESH:D013256
391 11626-11628 Chemical denotes E2 MESH:D004958
392 12041-12043 Chemical denotes E2 MESH:D004958
393 12470-12472 Chemical denotes E2 MESH:D004958
394 11873-11881 Disease denotes COVID-19 MESH:C000657245
395 11916-11936 Disease denotes SARS-CoV-2 infection MESH:C000657245
396 11969-11977 Disease denotes COVID-19 MESH:C000657245
397 12324-12341 Disease denotes myocardial stress MESH:D000079225
420 13268-13272 Gene denotes ACE2 Gene:59272
421 13345-13349 Gene denotes ACE2 Gene:59272
422 13513-13517 Gene denotes ACE2 Gene:59272
423 13551-13554 Gene denotes K27 Gene:342574
424 13737-13741 Gene denotes PRC1 Gene:9055
425 13908-13912 Gene denotes PRC1 Gene:9055
426 14178-14182 Gene denotes EZH2 Gene:2146
427 14242-14246 Gene denotes ACE2 Gene:59272
428 14267-14271 Gene denotes ACE2 Gene:59272
429 14323-14327 Gene denotes EZH2 Gene:2146
430 14391-14395 Gene denotes EZH2 Gene:2146
491 16576-16580 Gene denotes ACE2 Gene:59272
431 14411-14415 Gene denotes ACE2 Gene:59272
432 14488-14492 Gene denotes EZH2 Gene:2146
433 14568-14572 Gene denotes ACE2 Gene:59272
434 14693-14697 Gene denotes ACE2 Gene:59272
435 14852-14856 Gene denotes ACE2 Gene:59272
436 14286-14291 Species denotes human Tax:9606
437 14585-14590 Species denotes human Tax:9606
438 14630-14632 Chemical denotes H3 MESH:C012616
439 14782-14794 Disease denotes hypertension MESH:D006973
440 14796-14804 Disease denotes diabetes MESH:D003920
441 14810-14842 Disease denotes chronic obstructive lung disease MESH:D029424
46 78-109 Gene denotes Angiotensin-converting enzyme 2 Gene:59272
461 14981-14985 Gene denotes ACE2 Gene:59272
462 15042-15046 Gene denotes ACE2 Gene:59272
463 15297-15301 Gene denotes ACE2 Gene:59272
464 15510-15514 Gene denotes ACE2 Gene:59272
465 15600-15604 Gene denotes ACE2 Gene:59272
466 15696-15700 Gene denotes ACE2 Gene:59272
467 15869-15873 Gene denotes ACE2 Gene:59272
468 15935-15953 Gene denotes Vitamin D receptor Gene:7421
469 15955-15958 Gene denotes VDR Gene:7421
47 111-115 Gene denotes ACE2 Gene:59272
470 16024-16028 Gene denotes ACE2 Gene:59272
471 16049-16052 Gene denotes VDR Gene:7421
472 16083-16087 Gene denotes ACE2 Gene:59272
473 16189-16193 Gene denotes ACE2 Gene:59272
474 15687-15695 Species denotes children Tax:9606
475 16227-16237 Species denotes Sars-CoV-2 Tax:2697049
476 15856-15865 Chemical denotes Vitamin D MESH:D014807
477 16158-16167 Chemical denotes Vitamin D MESH:D014807
478 15557-15563 Disease denotes tumors MESH:D009369
479 16171-16179 Disease denotes COVID-19 MESH:C000657245
48 131-134 Gene denotes ACE Gene:1636
487 16283-16286 Gene denotes ACE Gene:1636
488 16287-16291 Gene denotes ACE2 Gene:59272
489 16489-16493 Gene denotes Brg1 Gene:6597
49 202-205 Gene denotes ACE Gene:1636
490 16522-16527 Gene denotes FoxM1 Gene:2305
492 16581-16584 Gene denotes ACE Gene:1636
493 16622-16641 Disease denotes cardiac hypertrophy MESH:D006332
498 16799-16806 Gene denotes miR-421 Gene:693122
499 16821-16825 Gene denotes ACE2 Gene:59272
50 207-211 Gene denotes ACE2 Gene:59272
500 16868-16875 Gene denotes miR-421 Gene:693122
501 16886-16890 Gene denotes ACE2 Gene:59272
51 296-300 Gene denotes ACE2 Gene:59272
52 425-429 Gene denotes ACE2 Gene:59272
521 17064-17068 Gene denotes ACE2 Gene:59272
522 17210-17214 Gene denotes ACE2 Gene:59272
523 17286-17290 Gene denotes ACE2 Gene:59272
524 17395-17399 Gene denotes ACE2 Gene:59272
525 17546-17550 Gene denotes ACE2 Gene:59272
526 17637-17641 Gene denotes ACE2 Gene:59272
527 17693-17699 Gene denotes Ang II Gene:24179
528 17710-17716 Gene denotes ADAM17 Gene:6868
529 17752-17756 Gene denotes ACE2 Gene:59272
53 549-553 Gene denotes ACE2 Gene:59272
530 17858-17862 Gene denotes ACE2 Gene:59272
531 17977-17983 Gene denotes ADAM17 Gene:6868
532 18018-18022 Gene denotes ACE2 Gene:59272
533 17582-17592 Gene denotes calmodulin Gene:801
534 17519-17529 Gene denotes calmodulin Gene:801
535 17077-17081 Gene denotes post Gene:159371
536 16993-16997 Gene denotes post Gene:159371
537 17130-17138 Gene denotes membrane Gene:43740571
538 18056-18066 Species denotes Sars-CoV-2 Tax:2697049
539 17889-17911 Disease denotes myocardial dysfunction MESH:D009202
54 667-671 Gene denotes ACE2 Gene:59272
543 18183-18187 Gene denotes ACE2 Gene:59272
544 18141-18145 Gene denotes post Gene:159371
545 18115-18119 Gene denotes post Gene:159371
548 18285-18289 Gene denotes ACE2 Gene:59272
549 18254-18258 Gene denotes post Gene:159371
55 766-770 Gene denotes ACE2 Gene:59272
56 1085-1089 Gene denotes ACE2 Gene:59272
561 18409-18413 Gene denotes ACE2 Gene:59272
562 18525-18529 Gene denotes ACE2 Gene:59272
563 18752-18756 Gene denotes ACE2 Gene:59272
564 19061-19065 Gene denotes ACE2 Gene:59272
565 19541-19545 Gene denotes ACE2 Gene:59272
566 19587-19591 Gene denotes ACE2 Gene:59272
567 18730-18731 Gene denotes S Gene:43740568
568 18476-18485 Species denotes mammalian Tax:9606
569 19643-19648 Species denotes human Tax:9606
57 1154-1158 Gene denotes ACE2 Gene:59272
570 18562-18583 Disease denotes cardiovascular system MESH:D002318
571 19649-19664 Disease denotes hemato-lymphoid MESH:D008224
575 19920-19924 Gene denotes ACE2 Gene:59272
576 20266-20270 Gene denotes ACE2 Gene:59272
577 20253-20258 Species denotes human Tax:9606
58 1399-1403 Gene denotes ACE2 Gene:59272
581 20458-20462 Gene denotes ACE2 Gene:59272
582 20504-20513 Species denotes mammalian Tax:9606
583 20525-20530 Species denotes human Tax:9606
59 1520-1523 Gene denotes ACE Gene:1636
599 21130-21134 Gene denotes ACE2 Gene:59272
60 1589-1593 Gene denotes ACE2 Gene:59272
600 21273-21277 Gene denotes ACE2 Gene:59272
601 21701-21705 Gene denotes ACE2 Gene:59272
602 21753-21757 Gene denotes ACE2 Gene:59272
603 21915-21919 Gene denotes ACE2 Gene:70008
604 22302-22305 Gene denotes age Gene:5973
605 22222-22225 Gene denotes age Gene:5973
606 21294-21299 Species denotes human Tax:9606
607 21626-21636 Species denotes SARS-CoV-2 Tax:2697049
608 22018-22023 Species denotes mouse Tax:10090
609 22025-22028 Species denotes rat Tax:10116
61 1854-1858 Gene denotes ACE2 Gene:59272
610 22035-22041 Species denotes ferret Tax:9669
611 22054-22059 Species denotes human Tax:9606
612 21645-21654 Disease denotes infection MESH:D007239
613 21710-21718 Disease denotes COVID-19 MESH:C000657245
62 2058-2062 Gene denotes ACE2 Gene:59272
620 22372-22376 Gene denotes ACE2 Gene:59272
621 22637-22641 Gene denotes ACE2 Gene:59272
622 23049-23053 Gene denotes ACE2 Gene:59272
623 22820-22825 Disease denotes colon MESH:D003110
624 22888-22893 Disease denotes colon MESH:D003110
625 23093-23113 Disease denotes endocrine pancreatic MESH:D010195
63 2172-2176 Gene denotes ACE2 Gene:59272
634 23204-23208 Gene denotes ACE2 Gene:70008
635 23308-23312 Gene denotes ACE2 Gene:70008
636 23986-23990 Gene denotes ACE2 Gene:70008
637 24137-24141 Gene denotes ACE2 Gene:70008
638 23243-23248 Species denotes mouse Tax:10090
639 23265-23278 Disease denotes telencephalon
64 2305-2309 Gene denotes ACE2 Gene:59272
640 23507-23535 Disease denotes hypothalamic paraventricular MESH:D007027
641 23550-23558 Disease denotes postrema
648 24332-24336 Gene denotes ACE2 Gene:59272
649 24421-24425 Gene denotes ACE2 Gene:59272
65 2428-2432 Gene denotes ACE2 Gene:59272
650 24568-24572 Gene denotes ACE2 Gene:59272
651 24407-24412 Species denotes human Tax:9606
652 24595-24600 Species denotes human Tax:9606
653 24601-24608 Disease denotes ovaries MESH:D010051
656 24826-24830 Gene denotes ACE2 Gene:59272
657 24957-24962 Species denotes human Tax:9606
66 1307-1315 Gene denotes envelope Gene:43740570
666 25044-25048 Gene denotes ACE2 Gene:59272
667 25231-25235 Gene denotes ACE2 Gene:59272
668 25341-25345 Gene denotes ACE2 Gene:59272
669 25409-25413 Gene denotes ACE2 Gene:59272
67 454-458 Gene denotes post Gene:159371
670 25578-25582 Gene denotes ACE2 Gene:59272
671 25436-25444 Gene denotes membrane Gene:43740571
672 25032-25037 Species denotes human Tax:9606
673 25448-25453 Species denotes human Tax:9606
675 25680-25684 Gene denotes ACE2 Gene:59272
68 347-351 Gene denotes post Gene:159371
688 25754-25758 Gene denotes ACE2 Gene:59272
689 25873-25877 Gene denotes ACE2 Gene:59272
69 1335-1343 Gene denotes membrane Gene:43740571
690 26002-26006 Gene denotes ACE2 Gene:59272
691 26096-26100 Gene denotes ACE2 Gene:59272
692 26118-26121 Gene denotes ACE Gene:1636
693 26170-26184 Gene denotes angiotensin II Gene:183
694 26219-26223 Gene denotes ACE2 Gene:70008
695 26300-26304 Gene denotes ACE2 Gene:70008
696 26478-26481 Gene denotes ACE Gene:1636
697 26584-26588 Gene denotes ACE2 Gene:70008
698 26287-26292 Species denotes mouse Tax:10090
699 26267-26277 Species denotes transgenic Tax:10090
70 539-547 Gene denotes membrane Gene:43740571
705 26711-26715 Gene denotes ACE2 Gene:59272
706 26829-26833 Gene denotes ACE2 Gene:59272
707 26943-26946 Gene denotes ACE Gene:1636
708 27168-27172 Gene denotes MasR Gene:116511
709 27082-27086 Gene denotes MasR Gene:116511
71 583-592 Species denotes mammalian Tax:9606
718 27254-27258 Gene denotes ACE2 Gene:59272
719 27280-27284 Gene denotes ACE2 Gene:59272
72 847-866 Species denotes SARS)-coronaviruses Tax:694009
720 27343-27349 Gene denotes ANG II Gene:24179
721 27382-27395 Gene denotes angiotensin I Gene:183
722 27473-27476 Gene denotes ACE Gene:1636
723 27582-27586 Gene denotes ACE2 Gene:59272
724 27626-27631 Gene denotes BKB1R Gene:623
725 27495-27499 Gene denotes MasR Gene:116511
73 889-898 Species denotes SARS-CoV2 Tax:2697049
737 27743-27747 Gene denotes ACE2 Gene:59272
738 28100-28104 Gene denotes ACE2 Gene:59272
739 28676-28680 Gene denotes ACE2 Gene:59272
74 1075-1084 Species denotes SARS-CoV2 Tax:2697049
740 27755-27759 Gene denotes MasR Gene:116511
741 28725-28730 Species denotes human Tax:9606
742 28742-28750 Species denotes patients Tax:9606
743 28164-28176 Chemical denotes nitric oxide MESH:D009569
744 28411-28433 Disease denotes myocardial hypertrophy MESH:D006332
745 28481-28502 Disease denotes myocardial infarction MESH:D009203
746 28763-28771 Disease denotes ischemic MESH:D007511
747 28775-28797 Disease denotes dilated cardiomyopathy MESH:D002311
75 1131-1140 Species denotes SARS-CoV2 Tax:2697049
76 1407-1416 Species denotes SARS-CoV2 Tax:2697049
760 28877-28881 Gene denotes ACE2 Gene:59272
761 28931-28935 Gene denotes ACE2 Gene:59272
762 29156-29160 Gene denotes ACE2 Gene:59272
763 29323-29327 Gene denotes MrgD Gene:116512
764 29385-29389 Gene denotes MrgD Gene:116512
765 28965-28978 Chemical denotes Angiotensin A
766 28980-28985 Chemical denotes Ang-A
767 29176-29183 Chemical denotes Ala-Ang
768 29204-29214 Chemical denotes alamandine MESH:C581752
769 29440-29450 Chemical denotes alamandine MESH:C581752
77 277-294 Disease denotes lung inflammation MESH:D011014
770 29424-29435 Disease denotes cardiopathy MESH:C536187
771 29498-29504 Disease denotes sepsis MESH:D018805
777 29535-29538 Gene denotes ACE Gene:1636
778 29540-29544 Gene denotes ACE2 Gene:59272
779 29562-29572 Gene denotes bradykinin Gene:3827
78 621-642 Disease denotes cardiovascular system MESH:D002318
780 29604-29614 Gene denotes bradykinin Gene:3827
781 29692-29714 Gene denotes B1 bradykinin receptor Gene:623
79 812-845 Disease denotes severe acute respiratory syndrome MESH:D045169
794 29779-29783 Gene denotes ACE2 Gene:59272
795 29806-29817 Gene denotes neurotensin Gene:4922
796 29893-29899 Gene denotes apelin Gene:8862
797 29944-29948 Gene denotes ACE2 Gene:59272
798 30070-30074 Gene denotes ACE2 Gene:59272
799 30198-30202 Gene denotes ACE2 Gene:59272
80 919-943 Disease denotes COronaVIrus Disease 2019 MESH:C000657245
800 30207-30213 Gene denotes Apelin Gene:8862
801 30103-30109 Gene denotes apelin Gene:8862
802 29819-29830 Chemical denotes dynorphin A
803 29843-29850 Chemical denotes ghrelin MESH:D054439
804 30012-30025 Disease denotes heart failure MESH:D006333
805 30277-30289 Disease denotes hypertension MESH:D006973
81 945-953 Disease denotes COVID-19 MESH:C000657245
811 30376-30380 Gene denotes ACE2 Gene:59272
812 30508-30511 Gene denotes ACE Gene:1636
813 30598-30602 Gene denotes MrgD Gene:116512
814 30575-30579 Gene denotes MasR Gene:116511
815 30587-30597 Chemical denotes Alamandine MESH:C581752
818 30691-30695 Gene denotes ACE2 Gene:59272
819 30700-30711 Disease denotes Lung Injury MESH:D055370
82 979-987 Disease denotes COVID-19 MESH:C000657245
83 1486-1498 Disease denotes hypertension MESH:D006973
831 30712-30716 Gene denotes ACE2 Gene:59272
832 30871-30875 Gene denotes ACE2 Gene:59272
833 30969-30972 Gene denotes ACE Gene:1636
834 30977-30991 Gene denotes angiotensin II Gene:183
835 30787-30802 Disease denotes pulmonary small MESH:D008171
836 30922-30934 Disease denotes lung disease MESH:D008171
837 31011-31028 Disease denotes acute lung injury MESH:D055371
838 31036-31054 Disease denotes pulmonary fibrosis MESH:D011658
839 31056-31078 Disease denotes pulmonary hypertension MESH:D006976
84 1626-1646 Disease denotes SARS-CoV-2 infection MESH:C000657245
840 31084-31119 Disease denotes acute respiratory distress syndrome MESH:D012128
841 31121-31125 Disease denotes ARDS MESH:D012128
85 1843-1852 Disease denotes infection MESH:D007239
858 31404-31408 Gene denotes ACE2 Gene:70008
859 31817-31821 Gene denotes ACE2 Gene:70008
86 2017-2025 Disease denotes COVID-19 MESH:C000657245
860 31307-31314 Species denotes anthrax Tax:1392
861 31350-31354 Species denotes H5N1 Tax:102793
862 31418-31422 Species denotes mice Tax:10090
863 31154-31158 Disease denotes ARDS MESH:D012128
864 31228-31239 Disease denotes lung injury MESH:D055370
865 31268-31274 Disease denotes sepsis MESH:D018805
866 31293-31305 Disease denotes pancreatitis MESH:D010195
867 31319-31335 Disease denotes virus infections MESH:D001102
868 31442-31446 Disease denotes ARDS MESH:D012128
869 31514-31520 Disease denotes sepsis MESH:D018805
87 2507-2515 Disease denotes COVID-19 MESH:C000657245
870 31539-31543 Disease denotes ARDS MESH:D012128
871 31594-31605 Disease denotes lung oedema MESH:D004487
872 31627-31639 Disease denotes inflammation MESH:D007249
873 31663-31697 Disease denotes impairment of respiratory function MESH:D012131
883 31889-31893 Gene denotes ACE2 Gene:59272
884 31939-31943 Gene denotes MasR Gene:116511
885 32458-32486 Gene denotes transforming growth factor β Gene:7124
886 32488-32494 Gene denotes TGF- β Gene:7039
887 31910-31927 Disease denotes lung inflammation MESH:D011014
888 31999-32014 Disease denotes allergic asthma MESH:D001249
889 32063-32075 Disease denotes inflammation MESH:D007249
890 32077-32085 Disease denotes fibrosis MESH:D005355
891 32259-32265 Disease denotes asthma MESH:D001249
900 32562-32566 Gene denotes ACE2 Gene:59272
901 32629-32634 Gene denotes BKB1R Gene:623
902 32660-32664 Gene denotes ACE2 Gene:70008
903 32780-32785 Gene denotes CXCL5 Gene:20311
904 32787-32791 Gene denotes MIP2 Gene:20310
905 32801-32806 Gene denotes TNF-α Gene:21926
906 32677-32682 Species denotes mouse Tax:10090
907 32587-32604 Disease denotes lung inflammation MESH:D011014
923 32871-32874 Gene denotes ACE Gene:1636
924 32875-32879 Gene denotes ACE2 Gene:59272
925 32971-32974 Gene denotes ACE Gene:1636
926 32988-32991 Gene denotes ACE Gene:1636
927 33022-33025 Gene denotes ACE Gene:1636
928 33049-33053 Gene denotes ACE2 Gene:59272
929 33180-33194 Gene denotes angiotensin II Gene:183
930 32864-32869 Species denotes human Tax:9606
931 33217-33225 Species denotes patients Tax:9606
932 33246-33263 Species denotes influenza viruses Tax:11308
933 33264-33268 Species denotes H5N1 Tax:102793
934 33086-33090 Disease denotes ARDS MESH:D012128
935 33110-33119 Disease denotes mortality MESH:D003643
936 33226-33234 Disease denotes infected MESH:D007239
937 33275-33277 CellLine denotes N9 CVCL:0452
940 11960-11964 Gene denotes ACE2 Gene:59272
941 11969-11977 Disease denotes COVID-19 MESH:C000657245
950 33424-33428 Gene denotes ACE2 Gene:59272
951 34288-34292 Gene denotes ACE2 Gene:59272
952 33897-33898 Gene denotes S Gene:43740568
953 33741-33752 Species denotes coronavirus Tax:11118
954 33770-33778 Species denotes SARS-CoV Tax:694009
955 33466-33495 Disease denotes respiratory infective disease MESH:D012141
956 34112-34163 Disease denotes SARS-CoV efficiently infected African Monkey kidney MESH:C000657245
957 34179-34181 CellLine denotes E6 CVCL:4582
976 35079-35083 Gene denotes ACE2 Gene:59272
977 35206-35210 Gene denotes ACE2 Gene:59272
978 34312-34320 Species denotes SARS-CoV Tax:694009
979 34441-34452 Species denotes coronavirus Tax:11118
98 2592-2621 Gene denotes Angiotensin-converting enzyme Gene:1636
980 34466-34471 Species denotes human Tax:9606
981 34621-34636 Species denotes new coronavirus Tax:2697049
982 34658-34668 Species denotes SARS-CoV-2 Tax:2697049
983 34702-34710 Species denotes SARS-CoV Tax:694009
984 34843-34853 Species denotes SARS-CoV-2 Tax:2697049
985 35055-35065 Species denotes SARS-CoV-2 Tax:2697049
986 35202-35205 Species denotes CoV Tax:11118
987 34376-34386 Disease denotes infections MESH:D007239
988 34539-34544 Disease denotes fever MESH:D005334
989 34553-34575 Disease denotes respiratory impairment MESH:D012131
99 2623-2626 Gene denotes ACE Gene:1636
990 34581-34590 Disease denotes pneumonia MESH:D011014
991 34768-34792 Disease denotes COronaVIrus Disease 2019 MESH:C000657245
992 35000-35008 Disease denotes COVID-19 MESH:C000657245
993 35107-35116 Disease denotes infection MESH:D007239
995 18730-18731 Gene denotes S Gene:43740568

LitCovid-sample-UniProt

Id Subject Object Predicate Lexical cue uniprot_id
T1 0-4 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2 78-109 Protein denotes Angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T17 111-115 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T18 131-134 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T43 202-205 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T68 207-211 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T69 296-300 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T70 425-429 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T71 549-553 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T72 667-671 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T73 766-770 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T74 1085-1089 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T75 1154-1158 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T76 1177-1188 Protein denotes (S) protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T109 1399-1403 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T110 1520-1523 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T135 1539-1550 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T136 1589-1593 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T137 1854-1858 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T138 2058-2062 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T139 2172-2176 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T140 2305-2309 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T141 2428-2432 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T142 2592-2621 Protein denotes Angiotensin-converting enzyme https://www.uniprot.org/uniprot/Q9VJV3|https://www.uniprot.org/uniprot/Q9TX66|https://www.uniprot.org/uniprot/Q9NKE4|https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6Q4G4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q27572|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q10715|https://www.uniprot.org/uniprot/Q10714|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/A4V0P3
T174 2623-2626 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T199 2741-2754 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T216 2759-2769 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T253 2817-2820 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T278 2921-2924 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T303 3057-3060 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T328 3142-3145 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T353 3176-3180 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T354 3283-3296 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T371 3349-3352 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T396 3438-3442 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T397 3476-3480 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T398 3534-3537 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T423 3573-3577 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T424 3662-3680 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T528 3732-3736 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T529 3873-3877 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T530 4128-4132 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T531 4248-4252 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T532 4268-4272 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T533 4452-4456 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T534 4655-4658 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T559 4670-4674 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T560 4691-4720 Protein denotes Angiotensin-converting enzyme https://www.uniprot.org/uniprot/Q9VJV3|https://www.uniprot.org/uniprot/Q9TX66|https://www.uniprot.org/uniprot/Q9NKE4|https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6Q4G4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q27572|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q10715|https://www.uniprot.org/uniprot/Q10714|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/A4V0P3
T592 4722-4725 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T617 4873-4876 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T642 4897-4900 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T667 5003-5019 Protein denotes membrane protein https://www.uniprot.org/uniprot/Q9WCD1|https://www.uniprot.org/uniprot/Q9QAR9|https://www.uniprot.org/uniprot/Q9PY97|https://www.uniprot.org/uniprot/Q9PWZ0|https://www.uniprot.org/uniprot/Q9JEB4|https://www.uniprot.org/uniprot/Q9J4B3|https://www.uniprot.org/uniprot/Q9J4A6|https://www.uniprot.org/uniprot/Q9J3P3|https://www.uniprot.org/uniprot/Q9J3P2|https://www.uniprot.org/uniprot/Q9J3P1|https://www.uniprot.org/uniprot/Q9J3P0|https://www.uniprot.org/uniprot/Q9J3N9|https://www.uniprot.org/uniprot/Q9J3N8|https://www.uniprot.org/uniprot/Q9IKC7|https://www.uniprot.org/uniprot/Q9DLM9|https://www.uniprot.org/uniprot/Q99AS5|https://www.uniprot.org/uniprot/Q91QS9|https://www.uniprot.org/uniprot/Q91GB7|https://www.uniprot.org/uniprot/Q91AU9|https://www.uniprot.org/uniprot/Q91A23|https://www.uniprot.org/uniprot/Q910E2|https://www.uniprot.org/uniprot/Q8V433|https://www.uniprot.org/uniprot/Q8JSP5|https://www.uniprot.org/uniprot/Q8BB24|https://www.uniprot.org/uniprot/Q7TA12|https://www.uniprot.org/uniprot/Q7T7S6|https://www.uniprot.org/uniprot/Q7T7P6|https://www.uniprot.org/uniprot/Q7T726|https://www.uniprot.org/uniprot/Q7T6S9|https://www.uniprot.org/uniprot/Q7T6S3|https://www.uniprot.org/uniprot/Q7T6S0|https://www.uniprot.org/uniprot/Q7T6R5|https://www.uniprot.org/uniprot/Q7T6R1|https://www.uniprot.org/uniprot/Q7T6Q8|https://www.uniprot.org/uniprot/Q6TNF6|https://www.uniprot.org/uniprot/Q6S8E5|https://www.uniprot.org/uniprot/Q6Q1R9|https://www.uniprot.org/uniprot/Q5MQC7|https://www.uniprot.org/uniprot/Q5I5X5|https://www.uniprot.org/uniprot/Q52PA8|https://www.uniprot.org/uniprot/Q4ZJS7|https://www.uniprot.org/uniprot/Q4U5F8|https://www.uniprot.org/uniprot/Q3T8I9|https://www.uniprot.org/uniprot/Q3LZX9|https://www.uniprot.org/uniprot/Q3I5J2|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q14EA7|https://www.uniprot.org/uniprot/Q0ZME4|https://www.uniprot.org/uniprot/Q0Q4E7|https://www.uniprot.org/uniprot/Q0Q472|https://www.uniprot.org/uniprot/Q0Q463|https://www.uniprot.org/uniprot/Q07504|https://www.uniprot.org/uniprot/Q04565|https://www.uniprot.org/uniprot/Q01455|https://www.uniprot.org/uniprot/Q008X3|https://www.uniprot.org/uniprot/P69705|https://www.uniprot.org/uniprot/P69704|https://www.uniprot.org/uniprot/P69703|https://www.uniprot.org/uniprot/P69607|https://www.uniprot.org/uniprot/P69606|https://www.uniprot.org/uniprot/P69605|https://www.uniprot.org/uniprot/P69604|https://www.uniprot.org/uniprot/P69603|https://www.uniprot.org/uniprot/P69602|https://www.uniprot.org/uniprot/P69601|https://www.uniprot.org/uniprot/P69600|https://www.uniprot.org/uniprot/P69599|https://www.uniprot.org/uniprot/P59771|https://www.uniprot.org/uniprot/P59770|https://www.uniprot.org/uniprot/P59596|https://www.uniprot.org/uniprot/P36359|https://www.uniprot.org/uniprot/P36299|https://www.uniprot.org/uniprot/P33464|https://www.uniprot.org/uniprot/P28991|https://www.uniprot.org/uniprot/P27904|https://www.uniprot.org/uniprot/P26021|https://www.uniprot.org/uniprot/P25878|https://www.uniprot.org/uniprot/P24412|https://www.uniprot.org/uniprot/P24266|https://www.uniprot.org/uniprot/P16629|https://www.uniprot.org/uniprot/P15422|https://www.uniprot.org/uniprot/P12649|https://www.uniprot.org/uniprot/P11222|https://www.uniprot.org/uniprot/P10526|https://www.uniprot.org/uniprot/P0DTC5|https://www.uniprot.org/uniprot/P09175|https://www.uniprot.org/uniprot/P08549|https://www.uniprot.org/uniprot/P05136|https://www.uniprot.org/uniprot/P04327|https://www.uniprot.org/uniprot/P04135|https://www.uniprot.org/uniprot/P03415|https://www.uniprot.org/uniprot/O90305|https://www.uniprot.org/uniprot/K9N7A1|https://www.uniprot.org/uniprot/A3EXG9|https://www.uniprot.org/uniprot/A3EXD6|https://www.uniprot.org/uniprot/A3EXA0|https://www.uniprot.org/uniprot/A0MD35
T764 5050-5053 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T789 5170-5173 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T814 5255-5260 Protein denotes renin https://www.uniprot.org/uniprot/Q9TSZ1|https://www.uniprot.org/uniprot/Q6T5C2|https://www.uniprot.org/uniprot/Q6FI38|https://www.uniprot.org/uniprot/Q6DYE7|https://www.uniprot.org/uniprot/Q6DLW5|https://www.uniprot.org/uniprot/Q6DLS0|https://www.uniprot.org/uniprot/Q63497|https://www.uniprot.org/uniprot/P60016|https://www.uniprot.org/uniprot/P52115|https://www.uniprot.org/uniprot/P08424|https://www.uniprot.org/uniprot/P00797
T825 5261-5272 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T826 5418-5421 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T851 5547-5560 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T868 5565-5575 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T905 5611-5614 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T930 5708-5721 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T947 5734-5748 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T964 5834-5837 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T989 5880-5890 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T1026 5956-5959 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1051 6078-6081 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1076 6357-6360 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1101 6516-6519 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1126 6529-6533 Protein denotes ACEH https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/C7ECU1
T1132 6663-6667 Protein denotes ACEH https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/C7ECU1
T1138 6728-6731 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1163 7056-7059 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1188 7075-7079 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1189 7113-7117 Protein denotes RACE https://www.uniprot.org/uniprot/O93323
T1190 7252-7256 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1191 7329-7332 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1216 7360-7363 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1241 7365-7369 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1242 7436-7440 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1243 7525-7529 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1244 7606-7610 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1245 7723-7727 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1246 7800-7804 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1247 7805-7809 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1248 7884-7887 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1273 7943-7947 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1274 7974-7977 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1299 7989-7993 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1300 8063-8067 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1301 8279-8283 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1302 8428-8431 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1327 8436-8440 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1328 8513-8516 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1353 8538-8542 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1354 8608-8612 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1355 8643-8656 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T1372 8660-8674 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T1389 8695-8705 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T1426 8717-8721 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1427 8740-8743 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1452 9026-9030 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1453 9119-9123 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1454 9275-9279 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1455 9711-9714 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1480 9719-9723 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1481 9825-9829 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1482 9922-9925 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1507 9956-9960 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1508 10078-10082 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1509 10143-10146 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1534 10175-10185 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1
T1542 10322-10326 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1543 10379-10389 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1
T1551 10761-10765 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1552 10786-10790 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1553 10849-10853 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1554 11133-11137 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1555 11531-11535 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1556 11643-11647 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1557 11781-11785 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1558 11901-11905 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1559 11960-11964 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1560 12054-12058 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1561 12159-12162 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1586 12202-12207 Protein denotes renin https://www.uniprot.org/uniprot/Q9TSZ1|https://www.uniprot.org/uniprot/Q6T5C2|https://www.uniprot.org/uniprot/Q6FI38|https://www.uniprot.org/uniprot/Q6DYE7|https://www.uniprot.org/uniprot/Q6DLW5|https://www.uniprot.org/uniprot/Q6DLS0|https://www.uniprot.org/uniprot/Q63497|https://www.uniprot.org/uniprot/P60016|https://www.uniprot.org/uniprot/P52115|https://www.uniprot.org/uniprot/P08424|https://www.uniprot.org/uniprot/P00797
T1597 12208-12219 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T1598 12404-12408 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1599 12432-12435 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1624 12476-12493 Protein denotes Estrogen Receptor https://www.uniprot.org/uniprot/Q9YHZ7|https://www.uniprot.org/uniprot/Q9YHT3|https://www.uniprot.org/uniprot/Q9YH33|https://www.uniprot.org/uniprot/Q9YGE6|https://www.uniprot.org/uniprot/Q9UIS7|https://www.uniprot.org/uniprot/Q9UDZ7|https://www.uniprot.org/uniprot/Q9TV98|https://www.uniprot.org/uniprot/Q9QZJ5|https://www.uniprot.org/uniprot/Q9QZG6|https://www.uniprot.org/uniprot/Q9QY52|https://www.uniprot.org/uniprot/Q9QY51|https://www.uniprot.org/uniprot/Q9PWP6|https://www.uniprot.org/uniprot/Q9PVZ9|https://www.uniprot.org/uniprot/Q9PSZ9|https://www.uniprot.org/uniprot/Q9PSZ8|https://www.uniprot.org/uniprot/Q9NU51|https://www.uniprot.org/uniprot/Q9JJT5|https://www.uniprot.org/uniprot/Q98SM9|https://www.uniprot.org/uniprot/Q95131|https://www.uniprot.org/uniprot/Q91424|https://www.uniprot.org/uniprot/Q91250|https://www.uniprot.org/uniprot/Q6QIS5|https://www.uniprot.org/uniprot/Q6MZQ9|https://www.uniprot.org/uniprot/Q5T5H7|https://www.uniprot.org/uniprot/Q53AD2|https://www.uniprot.org/uniprot/Q29040|https://www.uniprot.org/uniprot/Q14276|https://www.uniprot.org/uniprot/Q13511|https://www.uniprot.org/uniprot/P81559|https://www.uniprot.org/uniprot/P57753|https://www.uniprot.org/uniprot/P57717|https://www.uniprot.org/uniprot/P50242|https://www.uniprot.org/uniprot/P50241|https://www.uniprot.org/uniprot/P50240|https://www.uniprot.org/uniprot/P49886|https://www.uniprot.org/uniprot/P49885|https://www.uniprot.org/uniprot/P49884|https://www.uniprot.org/uniprot/P19785|https://www.uniprot.org/uniprot/P16058|https://www.uniprot.org/uniprot/P06212|https://www.uniprot.org/uniprot/P06211|https://www.uniprot.org/uniprot/P03372|https://www.uniprot.org/uniprot/O42174|https://www.uniprot.org/uniprot/O42132
T1668 12494-12499 Protein denotes alpha https://www.uniprot.org/uniprot/Q66765|https://www.uniprot.org/uniprot/Q66764|https://www.uniprot.org/uniprot/Q2V6G9|https://www.uniprot.org/uniprot/Q155Z9|https://www.uniprot.org/uniprot/P32540|https://www.uniprot.org/uniprot/P17594|https://www.uniprot.org/uniprot/P17593|https://www.uniprot.org/uniprot/P12296|https://www.uniprot.org/uniprot/P03304|https://www.uniprot.org/uniprot/C0MHL9|https://www.uniprot.org/uniprot/B8XTP8
T1679 12814-12845 Protein denotes Estrogen Related Receptor alpha https://www.uniprot.org/uniprot/Q6QMY5|https://www.uniprot.org/uniprot/Q5QJV7|https://www.uniprot.org/uniprot/Q3U110|https://www.uniprot.org/uniprot/Q3MHT1|https://www.uniprot.org/uniprot/Q14514|https://www.uniprot.org/uniprot/P11474|https://www.uniprot.org/uniprot/O08580|https://www.uniprot.org/uniprot/B2RRU9
T1687 12847-12850 Protein denotes ERR https://www.uniprot.org/uniprot/Q09143|https://www.uniprot.org/uniprot/P30824
T1689 12940-12944 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1690 13108-13112 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1691 13268-13272 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1692 13345-13349 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1693 13513-13517 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1694 13551-13554 Protein denotes K27 https://www.uniprot.org/uniprot/Q9Z320|https://www.uniprot.org/uniprot/Q7Z3Y8|https://www.uniprot.org/uniprot/Q6R649|https://www.uniprot.org/uniprot/Q6IFW8|https://www.uniprot.org/uniprot/Q0P5J6
T1699 14242-14246 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1700 14267-14271 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1701 14411-14415 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1702 14568-14572 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1703 14693-14697 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1704 14852-14856 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1705 14981-14985 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1706 15042-15046 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1707 15297-15301 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1708 15510-15514 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1709 15600-15604 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1710 15696-15700 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1711 15869-15873 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1712 15955-15958 Protein denotes VDR https://www.uniprot.org/uniprot/Q95MH5|https://www.uniprot.org/uniprot/Q922X0|https://www.uniprot.org/uniprot/Q5PSV3|https://www.uniprot.org/uniprot/Q28037|https://www.uniprot.org/uniprot/P49701|https://www.uniprot.org/uniprot/P48281|https://www.uniprot.org/uniprot/P13053|https://www.uniprot.org/uniprot/P11473|https://www.uniprot.org/uniprot/O42392|https://www.uniprot.org/uniprot/O13124|https://www.uniprot.org/uniprot/G3V1V9|https://www.uniprot.org/uniprot/B2R5Q1|https://www.uniprot.org/uniprot/A3RGC1
T1725 16024-16028 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1726 16049-16052 Protein denotes VDR https://www.uniprot.org/uniprot/Q95MH5|https://www.uniprot.org/uniprot/Q922X0|https://www.uniprot.org/uniprot/Q5PSV3|https://www.uniprot.org/uniprot/Q28037|https://www.uniprot.org/uniprot/P49701|https://www.uniprot.org/uniprot/P48281|https://www.uniprot.org/uniprot/P13053|https://www.uniprot.org/uniprot/P11473|https://www.uniprot.org/uniprot/O42392|https://www.uniprot.org/uniprot/O13124|https://www.uniprot.org/uniprot/G3V1V9|https://www.uniprot.org/uniprot/B2R5Q1|https://www.uniprot.org/uniprot/A3RGC1
T1739 16083-16087 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1740 16189-16193 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1741 16283-16286 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1766 16287-16291 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1767 16576-16580 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1768 16581-16584 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T1793 16821-16825 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1794 16886-16890 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1795 17064-17068 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1796 17183-17189 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T1805 17210-17214 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1806 17286-17290 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1807 17395-17399 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1808 17519-17529 Protein denotes calmodulin https://www.uniprot.org/uniprot/Q90496|https://www.uniprot.org/uniprot/Q8STF0|https://www.uniprot.org/uniprot/Q7T3T2|https://www.uniprot.org/uniprot/Q71UH6|https://www.uniprot.org/uniprot/Q6YNX6|https://www.uniprot.org/uniprot/Q6R520|https://www.uniprot.org/uniprot/Q6PI52|https://www.uniprot.org/uniprot/Q6IT78|https://www.uniprot.org/uniprot/Q61380|https://www.uniprot.org/uniprot/Q61379|https://www.uniprot.org/uniprot/Q5ZIQ6|https://www.uniprot.org/uniprot/Q5RAD2|https://www.uniprot.org/uniprot/Q4V949|https://www.uniprot.org/uniprot/Q2KJE6|https://www.uniprot.org/uniprot/Q08D84|https://www.uniprot.org/uniprot/P99014|https://www.uniprot.org/uniprot/P70667|https://www.uniprot.org/uniprot/P62184|https://www.uniprot.org/uniprot/P62160|https://www.uniprot.org/uniprot/P62157|https://www.uniprot.org/uniprot/P62156|https://www.uniprot.org/uniprot/P62154|https://www.uniprot.org/uniprot/P62152|https://www.uniprot.org/uniprot/P62151|https://www.uniprot.org/uniprot/P62149|https://www.uniprot.org/uniprot/P62145|https://www.uniprot.org/uniprot/P62144|https://www.uniprot.org/uniprot/P21251|https://www.uniprot.org/uniprot/P11121|https://www.uniprot.org/uniprot/P07181|https://www.uniprot.org/uniprot/P05935|https://www.uniprot.org/uniprot/P05934|https://www.uniprot.org/uniprot/P02596|https://www.uniprot.org/uniprot/P02595|https://www.uniprot.org/uniprot/P02594|https://www.uniprot.org/uniprot/P02593|https://www.uniprot.org/uniprot/O97341|https://www.uniprot.org/uniprot/O16305|https://www.uniprot.org/uniprot/O02367|https://www.uniprot.org/uniprot/Q9V3T4|https://www.uniprot.org/uniprot/Q9U6D3|https://www.uniprot.org/uniprot/Q9NDV6|https://www.uniprot.org/uniprot/Q9GRJ1|https://www.uniprot.org/uniprot/Q95NR9|https://www.uniprot.org/uniprot/Q95NI4
T1853 17546-17550 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1854 17582-17592 Protein denotes calmodulin https://www.uniprot.org/uniprot/Q90496|https://www.uniprot.org/uniprot/Q8STF0|https://www.uniprot.org/uniprot/Q7T3T2|https://www.uniprot.org/uniprot/Q71UH6|https://www.uniprot.org/uniprot/Q6YNX6|https://www.uniprot.org/uniprot/Q6R520|https://www.uniprot.org/uniprot/Q6PI52|https://www.uniprot.org/uniprot/Q6IT78|https://www.uniprot.org/uniprot/Q61380|https://www.uniprot.org/uniprot/Q61379|https://www.uniprot.org/uniprot/Q5ZIQ6|https://www.uniprot.org/uniprot/Q5RAD2|https://www.uniprot.org/uniprot/Q4V949|https://www.uniprot.org/uniprot/Q2KJE6|https://www.uniprot.org/uniprot/Q08D84|https://www.uniprot.org/uniprot/P99014|https://www.uniprot.org/uniprot/P70667|https://www.uniprot.org/uniprot/P62184|https://www.uniprot.org/uniprot/P62160|https://www.uniprot.org/uniprot/P62157|https://www.uniprot.org/uniprot/P62156|https://www.uniprot.org/uniprot/P62154|https://www.uniprot.org/uniprot/P62152|https://www.uniprot.org/uniprot/P62151|https://www.uniprot.org/uniprot/P62149|https://www.uniprot.org/uniprot/P62145|https://www.uniprot.org/uniprot/P62144|https://www.uniprot.org/uniprot/P21251|https://www.uniprot.org/uniprot/P11121|https://www.uniprot.org/uniprot/P07181|https://www.uniprot.org/uniprot/P05935|https://www.uniprot.org/uniprot/P05934|https://www.uniprot.org/uniprot/P02596|https://www.uniprot.org/uniprot/P02595|https://www.uniprot.org/uniprot/P02594|https://www.uniprot.org/uniprot/P02593|https://www.uniprot.org/uniprot/O97341|https://www.uniprot.org/uniprot/O16305|https://www.uniprot.org/uniprot/O02367|https://www.uniprot.org/uniprot/Q9V3T4|https://www.uniprot.org/uniprot/Q9U6D3|https://www.uniprot.org/uniprot/Q9NDV6|https://www.uniprot.org/uniprot/Q9GRJ1|https://www.uniprot.org/uniprot/Q95NR9|https://www.uniprot.org/uniprot/Q95NI4
T1899 17637-17641 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1900 17710-17716 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T1909 17752-17756 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1910 17858-17862 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1911 17977-17983 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T1920 18018-18022 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1921 18183-18187 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1922 18285-18289 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1923 18379-18383 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1924 18409-18413 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1925 18525-18529 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1926 18730-18739 Protein denotes S Protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T1959 18752-18756 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1960 18860-18866 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1963 19061-19065 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1964 19317-19323 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1967 19541-19545 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1968 19587-19591 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1969 19920-19924 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1970 20266-20270 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1971 20458-20462 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1972 21130-21134 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1973 21273-21277 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1974 21701-21705 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1975 21753-21757 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1976 21800-21806 Protein denotes lamina https://www.uniprot.org/uniprot/P13648|https://www.uniprot.org/uniprot/P11048
T1978 21915-21919 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1979 22372-22376 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1980 22637-22641 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1981 23049-23053 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1982 23204-23208 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1983 23308-23312 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1984 23440-23446 Protein denotes lamina https://www.uniprot.org/uniprot/P13648|https://www.uniprot.org/uniprot/P11048
T1986 23986-23990 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1987 24137-24141 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1988 24332-24336 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1989 24421-24425 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1990 24568-24572 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1991 24826-24830 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1992 25044-25048 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1993 25155-25161 Protein denotes Smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T1996 25231-25235 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1997 25341-25345 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1998 25409-25413 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T1999 25578-25582 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2000 25680-25684 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2001 25754-25758 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2002 25873-25877 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2003 26002-26006 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2004 26096-26100 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2005 26118-26121 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2030 26170-26184 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2047 26219-26223 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2048 26300-26304 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2049 26478-26481 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2074 26584-26588 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2075 26711-26715 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2076 26729-26745 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2077 26829-26833 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2078 26851-26864 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2095 26943-26946 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2120 27254-27258 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2121 27280-27284 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2122 27298-27314 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2123 27354-27358 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2133 27382-27395 Protein denotes angiotensin I https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2150 27463-27467 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2160 27473-27476 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2185 27478-27482 Protein denotes ANG1 https://www.uniprot.org/uniprot/Q9BDY8|https://www.uniprot.org/uniprot/Q8K4Q4|https://www.uniprot.org/uniprot/Q6NWV7|https://www.uniprot.org/uniprot/Q60FC1|https://www.uniprot.org/uniprot/Q5HYA0|https://www.uniprot.org/uniprot/Q15389|https://www.uniprot.org/uniprot/Q08DP8|https://www.uniprot.org/uniprot/O35460|https://www.uniprot.org/uniprot/O18920|https://www.uniprot.org/uniprot/O08538
T2195 27582-27586 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2196 27610-27620 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2233 27743-27747 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2234 28100-28104 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2235 28208-28214 Protein denotes smooth https://www.uniprot.org/uniprot/Q9VPM8|https://www.uniprot.org/uniprot/P91682|https://www.uniprot.org/uniprot/B7FNK1
T2238 28676-28680 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2239 28877-28881 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2240 28931-28935 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2241 28936-28952 Protein denotes carboxypeptidase https://www.uniprot.org/uniprot/P86516
T2242 28965-28976 Protein denotes Angiotensin https://www.uniprot.org/uniprot/Q10757
T2243 29156-29160 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2244 29286-29312 Protein denotes G-protein coupled receptor https://www.uniprot.org/uniprot/Q9QJ51|https://www.uniprot.org/uniprot/Q18LE5
T2246 29535-29538 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2271 29540-29544 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2272 29562-29572 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2309 29604-29614 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2346 29626-29645 Protein denotes des-Arg9 bradykinin https://www.uniprot.org/uniprot/P86628
T2347 29635-29645 Protein denotes bradykinin https://www.uniprot.org/uniprot/A0A088MIT0
T2348 29692-29714 Protein denotes B1 bradykinin receptor https://www.uniprot.org/uniprot/Q9Z1F4|https://www.uniprot.org/uniprot/Q9R250|https://www.uniprot.org/uniprot/Q9BDQ5|https://www.uniprot.org/uniprot/Q95L02|https://www.uniprot.org/uniprot/Q95L01|https://www.uniprot.org/uniprot/Q8N0Y8|https://www.uniprot.org/uniprot/Q8HZP3|https://www.uniprot.org/uniprot/Q8HZP2|https://www.uniprot.org/uniprot/Q8HZP1|https://www.uniprot.org/uniprot/Q8HZN9|https://www.uniprot.org/uniprot/Q61125|https://www.uniprot.org/uniprot/Q546S7|https://www.uniprot.org/uniprot/Q3BCU0|https://www.uniprot.org/uniprot/P97583|https://www.uniprot.org/uniprot/P48748|https://www.uniprot.org/uniprot/P46663|https://www.uniprot.org/uniprot/O35782|https://www.uniprot.org/uniprot/A8K7F5
T2366 29779-29783 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2367 29792-29801 Protein denotes apelin-13 https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08
T2373 29806-29817 Protein denotes neurotensin https://www.uniprot.org/uniprot/Q9TS28|https://www.uniprot.org/uniprot/Q9QV80|https://www.uniprot.org/uniprot/Q9D3P9|https://www.uniprot.org/uniprot/Q3ZCG0|https://www.uniprot.org/uniprot/P81796|https://www.uniprot.org/uniprot/P41536|https://www.uniprot.org/uniprot/P32560|https://www.uniprot.org/uniprot/P31745|https://www.uniprot.org/uniprot/P30990|https://www.uniprot.org/uniprot/P20068|https://www.uniprot.org/uniprot/P13724|https://www.uniprot.org/uniprot/P10673|https://www.uniprot.org/uniprot/P01156
T2386 29819-29837 Protein denotes dynorphin A (1–13) https://www.uniprot.org/uniprot/Q95104|https://www.uniprot.org/uniprot/Q63193|https://www.uniprot.org/uniprot/Q60478|https://www.uniprot.org/uniprot/P06300|https://www.uniprot.org/uniprot/P01214|https://www.uniprot.org/uniprot/P01213|https://www.uniprot.org/uniprot/O35417|https://www.uniprot.org/uniprot/A8K0Q3
T2394 29843-29850 Protein denotes ghrelin https://www.uniprot.org/uniprot/Q9WUZ1|https://www.uniprot.org/uniprot/Q9QYH7|https://www.uniprot.org/uniprot/Q9GKY6|https://www.uniprot.org/uniprot/Q9GKY5|https://www.uniprot.org/uniprot/Q9GKY4|https://www.uniprot.org/uniprot/Q9ET69|https://www.uniprot.org/uniprot/Q9EQX0|https://www.uniprot.org/uniprot/Q9BEF8|https://www.uniprot.org/uniprot/Q9BEF7|https://www.uniprot.org/uniprot/Q9BDJ6|https://www.uniprot.org/uniprot/Q9BDG8|https://www.uniprot.org/uniprot/Q90W22|https://www.uniprot.org/uniprot/Q8JFY4|https://www.uniprot.org/uniprot/Q8AUU1|https://www.uniprot.org/uniprot/Q76IQ4|https://www.uniprot.org/uniprot/Q76HE2|https://www.uniprot.org/uniprot/Q6BEG7|https://www.uniprot.org/uniprot/Q6BEG6|https://www.uniprot.org/uniprot/Q6BEG5|https://www.uniprot.org/uniprot/Q2I0G0|https://www.uniprot.org/uniprot/Q0VH85|https://www.uniprot.org/uniprot/A5X8W4|https://www.uniprot.org/uniprot/A0MLS4
T2417 29893-29899 Protein denotes apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2424 29944-29948 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2425 30070-30074 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2426 30103-30109 Protein denotes apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2433 30198-30202 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2434 30207-30213 Protein denotes Apelin https://www.uniprot.org/uniprot/Q9ULZ1|https://www.uniprot.org/uniprot/Q9TUI9|https://www.uniprot.org/uniprot/Q9R0R4|https://www.uniprot.org/uniprot/Q9R0R3|https://www.uniprot.org/uniprot/Q8WU89|https://www.uniprot.org/uniprot/Q4VY08|https://www.uniprot.org/uniprot/Q4TTN8
T2441 30376-30380 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2442 30508-30511 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2467 30691-30695 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2468 30712-30716 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2469 30871-30875 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2470 30969-30972 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2495 30977-30991 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2512 31404-31408 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2513 31817-31821 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2514 31889-31893 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2515 32471-32484 Protein denotes growth factor https://www.uniprot.org/uniprot/Q8V307|https://www.uniprot.org/uniprot/Q77PC4|https://www.uniprot.org/uniprot/Q776B5|https://www.uniprot.org/uniprot/Q6RZT5|https://www.uniprot.org/uniprot/P08441|https://www.uniprot.org/uniprot/P08072
T2521 32562-32566 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2522 32613-32623 Protein denotes bradykinin https://www.uniprot.org/uniprot/Q91XK5|https://www.uniprot.org/uniprot/Q90WZ1|https://www.uniprot.org/uniprot/Q90W88|https://www.uniprot.org/uniprot/Q90W16|https://www.uniprot.org/uniprot/Q7T3L1|https://www.uniprot.org/uniprot/Q7M4P1|https://www.uniprot.org/uniprot/Q6S9I1|https://www.uniprot.org/uniprot/Q6PAU9|https://www.uniprot.org/uniprot/Q53EQ0|https://www.uniprot.org/uniprot/Q32MX7|https://www.uniprot.org/uniprot/Q2KJ62|https://www.uniprot.org/uniprot/P86627|https://www.uniprot.org/uniprot/P86156|https://www.uniprot.org/uniprot/P84895|https://www.uniprot.org/uniprot/P84825|https://www.uniprot.org/uniprot/P84697|https://www.uniprot.org/uniprot/P84696|https://www.uniprot.org/uniprot/P84695|https://www.uniprot.org/uniprot/P83857|https://www.uniprot.org/uniprot/P83856|https://www.uniprot.org/uniprot/P83060|https://www.uniprot.org/uniprot/P83055|https://www.uniprot.org/uniprot/P0DM76|https://www.uniprot.org/uniprot/P08934|https://www.uniprot.org/uniprot/P08933|https://www.uniprot.org/uniprot/P01047|https://www.uniprot.org/uniprot/P01046|https://www.uniprot.org/uniprot/P01045|https://www.uniprot.org/uniprot/P01044|https://www.uniprot.org/uniprot/P01043|https://www.uniprot.org/uniprot/P01042|https://www.uniprot.org/uniprot/O08677|https://www.uniprot.org/uniprot/O08676|https://www.uniprot.org/uniprot/C9JEX1|https://www.uniprot.org/uniprot/B2RCR2|https://www.uniprot.org/uniprot/A8K474|https://www.uniprot.org/uniprot/A0A088MIT0
T2559 32660-32664 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2560 32787-32791 Protein denotes MIP2 https://www.uniprot.org/uniprot/Q5WA60|https://www.uniprot.org/uniprot/P30348|https://www.uniprot.org/uniprot/P10889
T2563 32871-32874 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2588 32875-32879 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2589 32971-32974 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2614 32988-32991 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2639 33022-33025 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T2664 33049-33053 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2665 33180-33194 Protein denotes angiotensin II https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T2682 33386-33390 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2683 33424-33428 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2684 33877-33895 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T2788 34210-34222 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T2873 34288-34292 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2874 35079-35083 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2875 35206-35210 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T2876 35267-35276 Protein denotes S Protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T2909 35305-35324 Protein denotes structural proteins https://www.uniprot.org/uniprot/Q6LEG6|https://www.uniprot.org/uniprot/Q04766|https://www.uniprot.org/uniprot/Q04765
T2912 35738-35750 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T2997 35921-35930 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3030 36148-36157 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3063 36533-36547 Protein denotes spike” protein https://www.uniprot.org/uniprot/P31340
T3064 36580-36589 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3097 37186-37189 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3106 37200-37203 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3115 37945-37955 Protein denotes S proteins https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3148 38087-38091 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3149 38237-38241 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3150 38427-38431 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3151 38530-38533 Protein denotes APN https://www.uniprot.org/uniprot/Q9UCE0|https://www.uniprot.org/uniprot/Q9JHP4|https://www.uniprot.org/uniprot/Q99K63|https://www.uniprot.org/uniprot/Q91YH8|https://www.uniprot.org/uniprot/Q8IVH3|https://www.uniprot.org/uniprot/Q8IUK3|https://www.uniprot.org/uniprot/Q6GT90|https://www.uniprot.org/uniprot/Q3MHR1|https://www.uniprot.org/uniprot/Q29242|https://www.uniprot.org/uniprot/Q16728|https://www.uniprot.org/uniprot/Q10737|https://www.uniprot.org/uniprot/P97449|https://www.uniprot.org/uniprot/P91887|https://www.uniprot.org/uniprot/P91885|https://www.uniprot.org/uniprot/P81731|https://www.uniprot.org/uniprot/P79171|https://www.uniprot.org/uniprot/P79143|https://www.uniprot.org/uniprot/P79098|https://www.uniprot.org/uniprot/P15684|https://www.uniprot.org/uniprot/P15541|https://www.uniprot.org/uniprot/P15145|https://www.uniprot.org/uniprot/P15144|https://www.uniprot.org/uniprot/O97783|https://www.uniprot.org/uniprot/F1PCB5
T3175 38724-38728 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3176 39154-39163 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3209 39391-39394 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3218 39631-39634 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3227 40015-40018 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3236 41266-41275 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3269 41641-41649 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T3513 41920-41929 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3546 42254-42263 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T3579 42328-42331 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T3588 42547-42551 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T3589 42939-42947 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T3833 42948-42953 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T3841 43039-43051 Protein denotes glycoprotein https://www.uniprot.org/uniprot/Q9QSP1|https://www.uniprot.org/uniprot/Q9QJT6|https://www.uniprot.org/uniprot/Q9JGT4|https://www.uniprot.org/uniprot/Q9IPJ6|https://www.uniprot.org/uniprot/Q9DIC6|https://www.uniprot.org/uniprot/Q91DS0|https://www.uniprot.org/uniprot/Q91C28|https://www.uniprot.org/uniprot/Q8QQA2|https://www.uniprot.org/uniprot/Q8QPE5|https://www.uniprot.org/uniprot/Q8QPE4|https://www.uniprot.org/uniprot/Q8QPE3|https://www.uniprot.org/uniprot/Q8JTH0|https://www.uniprot.org/uniprot/Q8BDV6|https://www.uniprot.org/uniprot/Q8B6J6|https://www.uniprot.org/uniprot/Q8B0I1|https://www.uniprot.org/uniprot/Q8B0H6|https://www.uniprot.org/uniprot/Q8B0H1|https://www.uniprot.org/uniprot/Q89669|https://www.uniprot.org/uniprot/Q85213|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q82020|https://www.uniprot.org/uniprot/Q787B5|https://www.uniprot.org/uniprot/Q77SK0|https://www.uniprot.org/uniprot/Q77N36|https://www.uniprot.org/uniprot/Q76G52|https://www.uniprot.org/uniprot/Q75T09|https://www.uniprot.org/uniprot/Q6X1D5|https://www.uniprot.org/uniprot/Q6X1D1|https://www.uniprot.org/uniprot/Q6TYA0|https://www.uniprot.org/uniprot/Q6E0W7|https://www.uniprot.org/uniprot/Q66T62|https://www.uniprot.org/uniprot/Q5VKP3|https://www.uniprot.org/uniprot/Q5VKN9|https://www.uniprot.org/uniprot/Q5K2K4|https://www.uniprot.org/uniprot/Q5IX93|https://www.uniprot.org/uniprot/Q5IX92|https://www.uniprot.org/uniprot/Q5IX91|https://www.uniprot.org/uniprot/Q5IX90|https://www.uniprot.org/uniprot/Q5IX89|https://www.uniprot.org/uniprot/Q5IX88|https://www.uniprot.org/uniprot/Q5IX87|https://www.uniprot.org/uniprot/Q5GA86|https://www.uniprot.org/uniprot/Q58FH1|https://www.uniprot.org/uniprot/Q4VKV3|https://www.uniprot.org/uniprot/Q4F900|https://www.uniprot.org/uniprot/Q49LL3|https://www.uniprot.org/uniprot/Q49IU2|https://www.uniprot.org/uniprot/Q49IU1|https://www.uniprot.org/uniprot/Q49IT9|https://www.uniprot.org/uniprot/Q49IT8|https://www.uniprot.org/uniprot/Q49AV0|https://www.uniprot.org/uniprot/Q0GBY1|https://www.uniprot.org/uniprot/Q0GBX6|https://www.uniprot.org/uniprot/Q08089|https://www.uniprot.org/uniprot/P32595|https://www.uniprot.org/uniprot/P32550|https://www.uniprot.org/uniprot/P19462|https://www.uniprot.org/uniprot/P16288|https://www.uniprot.org/uniprot/P15199|https://www.uniprot.org/uniprot/P13180|https://www.uniprot.org/uniprot/P0C572|https://www.uniprot.org/uniprot/P08667|https://www.uniprot.org/uniprot/P08163|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P04884|https://www.uniprot.org/uniprot/P04883|https://www.uniprot.org/uniprot/P04882|https://www.uniprot.org/uniprot/P03524|https://www.uniprot.org/uniprot/P03522|https://www.uniprot.org/uniprot/O92284|https://www.uniprot.org/uniprot/O56677|https://www.uniprot.org/uniprot/O10236|https://www.uniprot.org/uniprot/J7HBH4|https://www.uniprot.org/uniprot/D8V075|https://www.uniprot.org/uniprot/A7WNB3|https://www.uniprot.org/uniprot/A4UHQ6|https://www.uniprot.org/uniprot/A4UHQ1|https://www.uniprot.org/uniprot/A3RM22|https://www.uniprot.org/uniprot/A3F5R8|https://www.uniprot.org/uniprot/A3F5R3|https://www.uniprot.org/uniprot/A3F5Q8|https://www.uniprot.org/uniprot/A3F5N3|https://www.uniprot.org/uniprot/A3F5M3|https://www.uniprot.org/uniprot/A3F5L8
T3926 43184-43189 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T3934 43338-43346 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4178 43392-43397 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4186 43402-43407 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4194 43443-43465 Protein denotes trypsin-like proteases https://www.uniprot.org/uniprot/Q9UBX7|https://www.uniprot.org/uniprot/Q9NS65|https://www.uniprot.org/uniprot/Q8IXD7|https://www.uniprot.org/uniprot/Q0WXX5|https://www.uniprot.org/uniprot/O75837
T4199 43629-43640 Protein denotes cathepsin L https://www.uniprot.org/uniprot/Q9QV07|https://www.uniprot.org/uniprot/Q9GL24|https://www.uniprot.org/uniprot/Q9GKL8|https://www.uniprot.org/uniprot/Q96QJ0|https://www.uniprot.org/uniprot/Q95029|https://www.uniprot.org/uniprot/Q91UZ0|https://www.uniprot.org/uniprot/Q6IAV1|https://www.uniprot.org/uniprot/Q5U121|https://www.uniprot.org/uniprot/Q3T0P2|https://www.uniprot.org/uniprot/Q28944|https://www.uniprot.org/uniprot/Q26636|https://www.uniprot.org/uniprot/Q26534|https://www.uniprot.org/uniprot/Q10991|https://www.uniprot.org/uniprot/P25975|https://www.uniprot.org/uniprot/P25773|https://www.uniprot.org/uniprot/P09648|https://www.uniprot.org/uniprot/P07711|https://www.uniprot.org/uniprot/P07154|https://www.uniprot.org/uniprot/P06797|https://www.uniprot.org/uniprot/O97431|https://www.uniprot.org/uniprot/O77502|https://www.uniprot.org/uniprot/M3WXJ1
T4221 43858-43866 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4465 44188-44193 Protein denotes furin https://www.uniprot.org/uniprot/Q9UCZ5|https://www.uniprot.org/uniprot/Q6LBS3|https://www.uniprot.org/uniprot/Q6GTN6|https://www.uniprot.org/uniprot/Q28193|https://www.uniprot.org/uniprot/Q14336|https://www.uniprot.org/uniprot/P23377|https://www.uniprot.org/uniprot/P23188|https://www.uniprot.org/uniprot/P09958
T4473 44370-44378 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4717 44643-44651 Protein denotes protease https://www.uniprot.org/uniprot/Q9Y6I0|https://www.uniprot.org/uniprot/Q9WJC5|https://www.uniprot.org/uniprot/Q9WF19|https://www.uniprot.org/uniprot/Q9WC63|https://www.uniprot.org/uniprot/Q9WC54|https://www.uniprot.org/uniprot/Q9UKI1|https://www.uniprot.org/uniprot/Q9UKI0|https://www.uniprot.org/uniprot/Q9UKH6|https://www.uniprot.org/uniprot/Q9UKH5|https://www.uniprot.org/uniprot/P04323|https://www.uniprot.org/uniprot/P04023|https://www.uniprot.org/uniprot/P03371|https://www.uniprot.org/uniprot/P03370|https://www.uniprot.org/uniprot/P03369|https://www.uniprot.org/uniprot/P03368|https://www.uniprot.org/uniprot/P03367|https://www.uniprot.org/uniprot/P03366|https://www.uniprot.org/uniprot/P03365|https://www.uniprot.org/uniprot/P03363|https://www.uniprot.org/uniprot/P03362|https://www.uniprot.org/uniprot/P03361|https://www.uniprot.org/uniprot/P03360|https://www.uniprot.org/uniprot/P03359|https://www.uniprot.org/uniprot/P03357|https://www.uniprot.org/uniprot/P03356|https://www.uniprot.org/uniprot/P03355|https://www.uniprot.org/uniprot/P03353|https://www.uniprot.org/uniprot/P03253|https://www.uniprot.org/uniprot/P03252|https://www.uniprot.org/uniprot/P03234|https://www.uniprot.org/uniprot/O93215|https://www.uniprot.org/uniprot/O92808|https://www.uniprot.org/uniprot/O91080|https://www.uniprot.org/uniprot/O89940|https://www.uniprot.org/uniprot/O89811|https://www.uniprot.org/uniprot/O89290|https://www.uniprot.org/uniprot/O73194|https://www.uniprot.org/uniprot/O71150|https://www.uniprot.org/uniprot/O71070|https://www.uniprot.org/uniprot/O56228|https://www.uniprot.org/uniprot/O56227|https://www.uniprot.org/uniprot/O41798|https://www.uniprot.org/uniprot/O40958|https://www.uniprot.org/uniprot/O36367|https://www.uniprot.org/uniprot/O12158|https://www.uniprot.org/uniprot/O09798|https://www.uniprot.org/uniprot/O09777|https://www.uniprot.org/uniprot/D2K3N9|https://www.uniprot.org/uniprot/D2K3N8|https://www.uniprot.org/uniprot/D0UZM9|https://www.uniprot.org/uniprot/A0A0U3TYK5|https://www.uniprot.org/uniprot/A0A0A8IBU6|https://www.uniprot.org/uniprot/Q9UKH4|https://www.uniprot.org/uniprot/Q9QSR3|https://www.uniprot.org/uniprot/Q9QM72|https://www.uniprot.org/uniprot/Q9QJ30|https://www.uniprot.org/uniprot/Q9QBZ9|https://www.uniprot.org/uniprot/Q9QBZ5|https://www.uniprot.org/uniprot/Q9QBZ1|https://www.uniprot.org/uniprot/Q9QBY3|https://www.uniprot.org/uniprot/Q9Q720|https://www.uniprot.org/uniprot/Q9IZT3|https://www.uniprot.org/uniprot/Q9IZT2|https://www.uniprot.org/uniprot/Q9IRA3|https://www.uniprot.org/uniprot/Q9IIH4|https://www.uniprot.org/uniprot/Q9IDV9|https://www.uniprot.org/uniprot/Q9E6P2|https://www.uniprot.org/uniprot/Q9E6P1|https://www.uniprot.org/uniprot/Q96629|https://www.uniprot.org/uniprot/Q91QZ3|https://www.uniprot.org/uniprot/Q8JN66|https://www.uniprot.org/uniprot/Q8I7P9|https://www.uniprot.org/uniprot/Q8AII1|https://www.uniprot.org/uniprot/Q89928|https://www.uniprot.org/uniprot/Q89855|https://www.uniprot.org/uniprot/Q89703|https://www.uniprot.org/uniprot/Q89548|https://www.uniprot.org/uniprot/Q88140|https://www.uniprot.org/uniprot/Q85590|https://www.uniprot.org/uniprot/Q85571|https://www.uniprot.org/uniprot/Q85570|https://www.uniprot.org/uniprot/Q84177|https://www.uniprot.org/uniprot/Q83906|https://www.uniprot.org/uniprot/Q83417|https://www.uniprot.org/uniprot/Q82859|https://www.uniprot.org/uniprot/Q82851|https://www.uniprot.org/uniprot/Q7SVK7|https://www.uniprot.org/uniprot/Q7M6L1|https://www.uniprot.org/uniprot/Q7M6L0|https://www.uniprot.org/uniprot/Q79666|https://www.uniprot.org/uniprot/Q79582|https://www.uniprot.org/uniprot/Q77906|https://www.uniprot.org/uniprot/Q777B6|https://www.uniprot.org/uniprot/Q77373|https://www.uniprot.org/uniprot/Q76634|https://www.uniprot.org/uniprot/Q76629|https://www.uniprot.org/uniprot/Q76605|https://www.uniprot.org/uniprot/Q75002|https://www.uniprot.org/uniprot/Q74120|https://www.uniprot.org/uniprot/Q73368|https://www.uniprot.org/uniprot/Q6UDK6|https://www.uniprot.org/uniprot/Q6UDK5|https://www.uniprot.org/uniprot/Q6SW62|https://www.uniprot.org/uniprot/Q6SW61|https://www.uniprot.org/uniprot/Q6S6T7|https://www.uniprot.org/uniprot/Q6S6T6|https://www.uniprot.org/uniprot/Q69263|https://www.uniprot.org/uniprot/Q69030|https://www.uniprot.org/uniprot/Q66541|https://www.uniprot.org/uniprot/Q65ZF9|https://www.uniprot.org/uniprot/Q65652|https://www.uniprot.org/uniprot/Q65593|https://www.uniprot.org/uniprot/Q64962|https://www.uniprot.org/uniprot/Q61577|https://www.uniprot.org/uniprot/Q5TJ03|https://www.uniprot.org/uniprot/Q4U0X6|https://www.uniprot.org/uniprot/Q3KSP9|https://www.uniprot.org/uniprot/Q2Q1R2|https://www.uniprot.org/uniprot/Q2HRB6|https://www.uniprot.org/uniprot/Q2HRB5|https://www.uniprot.org/uniprot/Q27YG9|https://www.uniprot.org/uniprot/Q1HVC7|https://www.uniprot.org/uniprot/Q18LE3|https://www.uniprot.org/uniprot/Q0R5R3|https://www.uniprot.org/uniprot/Q0R5R2|https://www.uniprot.org/uniprot/Q09SZ9|https://www.uniprot.org/uniprot/Q02836|https://www.uniprot.org/uniprot/Q01002|https://www.uniprot.org/uniprot/P90341|https://www.uniprot.org/uniprot/P89449|https://www.uniprot.org/uniprot/P87563|https://www.uniprot.org/uniprot/P84454|https://www.uniprot.org/uniprot/P68986|https://www.uniprot.org/uniprot/P68985|https://www.uniprot.org/uniprot/P68984|https://www.uniprot.org/uniprot/P63131|https://www.uniprot.org/uniprot/P63129|https://www.uniprot.org/uniprot/P63128|https://www.uniprot.org/uniprot/P63127|https://www.uniprot.org/uniprot/P63125|https://www.uniprot.org/uniprot/P63124|https://www.uniprot.org/uniprot/P63123|https://www.uniprot.org/uniprot/P63122|https://www.uniprot.org/uniprot/P63121|https://www.uniprot.org/uniprot/P63120|https://www.uniprot.org/uniprot/P63119|https://www.uniprot.org/uniprot/P54817|https://www.uniprot.org/uniprot/P52369|https://www.uniprot.org/uniprot/P52351|https://www.uniprot.org/uniprot/P42672|https://www.uniprot.org/uniprot/P35990|https://www.uniprot.org/uniprot/P35963|https://www.uniprot.org/uniprot/P35956|https://www.uniprot.org/uniprot/P33459|https://www.uniprot.org/uniprot/P32542|https://www.uniprot.org/uniprot/P31822|https://www.uniprot.org/uniprot/P30202|https://www.uniprot.org/uniprot/P28936|https://www.uniprot.org/uniprot/P27980|https://www.uniprot.org/uniprot/P27973|https://www.uniprot.org/uniprot/P27528|https://www.uniprot.org/uniprot/P27502|https://www.uniprot.org/uniprot/P26810|https://www.uniprot.org/uniprot/P26809|https://www.uniprot.org/uniprot/P26808|https://www.uniprot.org/uniprot/P25059|https://www.uniprot.org/uniprot/P24740|https://www.uniprot.org/uniprot/P24433|https://www.uniprot.org/uniprot/P24107|https://www.uniprot.org/uniprot/P23984|https://www.uniprot.org/uniprot/P23427|https://www.uniprot.org/uniprot/P23426|https://www.uniprot.org/uniprot/P22382|https://www.uniprot.org/uniprot/P21414|https://www.uniprot.org/uniprot/P20892|https://www.uniprot.org/uniprot/P20876|https://www.uniprot.org/uniprot/P20875|https://www.uniprot.org/uniprot/P20825|https://www.uniprot.org/uniprot/P19561|https://www.uniprot.org/uniprot/P19560|https://www.uniprot.org/uniprot/P19505|https://www.uniprot.org/uniprot/P19202|https://www.uniprot.org/uniprot/P19199|https://www.uniprot.org/uniprot/P19151|https://www.uniprot.org/uniprot/P19119|https://www.uniprot.org/uniprot/P19028|https://www.uniprot.org/uniprot/P18802|https://www.uniprot.org/uniprot/P18096|https://www.uniprot.org/uniprot/P18042|https://www.uniprot.org/uniprot/P17965|https://www.uniprot.org/uniprot/P17757|https://www.uniprot.org/uniprot/P17283|https://www.uniprot.org/uniprot/P16901|https://www.uniprot.org/uniprot/P16753|https://www.uniprot.org/uniprot/P16423|https://www.uniprot.org/uniprot/P16088|https://www.uniprot.org/uniprot/P16046|https://www.uniprot.org/uniprot/P15833|https://www.uniprot.org/uniprot/P14078|https://www.uniprot.org/uniprot/P14074|https://www.uniprot.org/uniprot/P12502|https://www.uniprot.org/uniprot/P12499|https://www.uniprot.org/uniprot/P12498|https://www.uniprot.org/uniprot/P12497|https://www.uniprot.org/uniprot/P12451|https://www.uniprot.org/uniprot/P11826|https://www.uniprot.org/uniprot/P11825|https://www.uniprot.org/uniprot/P11365|https://www.uniprot.org/uniprot/P11283|https://www.uniprot.org/uniprot/P11227|https://www.uniprot.org/uniprot/P11204|https://www.uniprot.org/uniprot/P10394|https://www.uniprot.org/uniprot/P10381|https://www.uniprot.org/uniprot/P10274|https://www.uniprot.org/uniprot/P10273|https://www.uniprot.org/uniprot/P10272|https://www.uniprot.org/uniprot/P10271|https://www.uniprot.org/uniprot/P10270|https://www.uniprot.org/uniprot/P10265|https://www.uniprot.org/uniprot/P10210|https://www.uniprot.org/uniprot/P0DOI1|https://www.uniprot.org/uniprot/P0DOI0|https://www.uniprot.org/uniprot/P0C6F2|https://www.uniprot.org/uniprot/P0C211|https://www.uniprot.org/uniprot/P0C210|https://www.uniprot.org/uniprot/P09569|https://www.uniprot.org/uniprot/P09286|https://www.uniprot.org/uniprot/P08361|https://www.uniprot.org/uniprot/P07885|https://www.uniprot.org/uniprot/P05962|https://www.uniprot.org/uniprot/P05961|https://www.uniprot.org/uniprot/P05960|https://www.uniprot.org/uniprot/P05959|https://www.uniprot.org/uniprot/P05897|https://www.uniprot.org/uniprot/P05896|https://www.uniprot.org/uniprot/P05895|https://www.uniprot.org/uniprot/P04589|https://www.uniprot.org/uniprot/P04588|https://www.uniprot.org/uniprot/P04587|https://www.uniprot.org/uniprot/P04585|https://www.uniprot.org/uniprot/P04584|https://www.uniprot.org/uniprot/Q1HVC6|https://www.uniprot.org/uniprot/Q1A267|https://www.uniprot.org/uniprot/Q1A249
T4961 44925-44928 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4970 44947-44951 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T4971 45077-45080 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4980 45109-45112 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T4989 45148-45157 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5022 45292-45295 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5031 45410-45413 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5040 45521-45525 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5041 45555-45558 Protein denotes HEK https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320
T5044 45674-45678 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5045 45732-45736 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5046 45797-45800 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5055 45904-45907 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5064 46347-46350 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5073 46608-46612 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5074 46721-46724 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5083 46788-46791 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5092 46987-46990 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5101 46996-47000 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5102 47084-47087 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5111 47171-47180 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5144 47190-47193 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5153 47315-47319 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5154 47320-47323 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5163 47555-47558 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5172 47584-47588 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5173 47622-47625 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5182 47816-47820 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5183 47975-47979 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5184 48023-48032 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5217 48150-48153 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5226 48217-48220 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5235 48498-48502 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5236 48536-48539 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5245 48599-48608 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5278 48842-48853 Protein denotes (S) protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5311 48879-48883 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5312 48939-48942 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5334 48979-48982 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5356 49028-49031 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5378 49068-49071 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5387 49081-49084 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5409 49121-49124 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5418 49132-49135 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5440 49177-49180 Protein denotes SPR https://www.uniprot.org/uniprot/Q9UBB1|https://www.uniprot.org/uniprot/Q98982|https://www.uniprot.org/uniprot/Q8R536|https://www.uniprot.org/uniprot/Q8BYR7|https://www.uniprot.org/uniprot/Q7ZY31|https://www.uniprot.org/uniprot/Q64105|https://www.uniprot.org/uniprot/Q63996|https://www.uniprot.org/uniprot/Q5DUB3|https://www.uniprot.org/uniprot/Q5DUB1|https://www.uniprot.org/uniprot/Q53GI9|https://www.uniprot.org/uniprot/Q17QK8|https://www.uniprot.org/uniprot/P35270|https://www.uniprot.org/uniprot/P30548|https://www.uniprot.org/uniprot/P30547|https://www.uniprot.org/uniprot/P25103|https://www.uniprot.org/uniprot/P18297|https://www.uniprot.org/uniprot/P14600|https://www.uniprot.org/uniprot/D6W5H2|https://www.uniprot.org/uniprot/B0BML7|https://www.uniprot.org/uniprot/A8K741|https://www.uniprot.org/uniprot/A8K150|https://www.uniprot.org/uniprot/A7YKV0
T5462 49353-49357 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5463 49358-49361 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5472 49442-49446 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5473 49521-49524 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5482 49623-49627 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5483 49645-49648 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5492 49886-49890 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5493 49902-49905 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5502 50203-50212 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5535 50218-50221 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5544 50324-50327 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5553 50342-50346 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5554 50407-50411 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5555 50434-50443 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5588 50560-50564 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5589 50574-50577 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5598 50582-50586 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5599 50598-50601 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5608 50781-50785 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5609 50932-50935 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5618 51379-51383 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5619 51579-51583 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5620 51823-51827 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5621 51909-51913 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5622 52025-52029 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5623 52192-52196 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5624 52388-52392 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5625 52456-52459 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5634 52810-52814 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5635 52867-52876 Protein denotes S protein https://www.uniprot.org/uniprot/Q9UIP0|https://www.uniprot.org/uniprot/Q9UIN9|https://www.uniprot.org/uniprot/Q9UIN8|https://www.uniprot.org/uniprot/Q9UIN7|https://www.uniprot.org/uniprot/Q9UIN6|https://www.uniprot.org/uniprot/Q9UBH8|https://www.uniprot.org/uniprot/Q9NRH8|https://www.uniprot.org/uniprot/Q9NRH7|https://www.uniprot.org/uniprot/Q9NRH6|https://www.uniprot.org/uniprot/Q9NRH5|https://www.uniprot.org/uniprot/Q9NRH4|https://www.uniprot.org/uniprot/Q9NPG5|https://www.uniprot.org/uniprot/Q9NPE0|https://www.uniprot.org/uniprot/Q9NP52|https://www.uniprot.org/uniprot/Q95IF9|https://www.uniprot.org/uniprot/Q8N5P3|https://www.uniprot.org/uniprot/Q8IZU6|https://www.uniprot.org/uniprot/Q8IZU5|https://www.uniprot.org/uniprot/Q8IZU4|https://www.uniprot.org/uniprot/Q86Z04|https://www.uniprot.org/uniprot/Q7YR44|https://www.uniprot.org/uniprot/Q7LA71|https://www.uniprot.org/uniprot/Q7LA70|https://www.uniprot.org/uniprot/Q5STD2|https://www.uniprot.org/uniprot/Q5SQ85|https://www.uniprot.org/uniprot/Q1XI16|https://www.uniprot.org/uniprot/Q1XI12|https://www.uniprot.org/uniprot/Q15517|https://www.uniprot.org/uniprot/O43509|https://www.uniprot.org/uniprot/O19084|https://www.uniprot.org/uniprot/B0UYZ7|https://www.uniprot.org/uniprot/B0S7V2|https://www.uniprot.org/uniprot/A5A6L9
T5668 52986-52990 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5669 53094-53098 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5670 53303-53306 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T5679 53383-53386 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5704 53533-53537 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5705 53723-53727 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5706 53783-53787 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5707 53837-53841 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5708 54005-54009 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5709 56254-56257 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5734 56395-56399 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5735 56556-56560 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5736 57665-57668 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5761 57683-57694 Protein denotes angiotensin https://www.uniprot.org/uniprot/Q10757
T5762 58004-58008 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5763 58063-58067 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5764 58070-58074 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5765 58221-58225 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5766 58479-58483 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5767 58650-58654 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5768 58771-58775 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5769 60004-60008 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5770 60033-60037 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5771 60166-60170 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5772 60318-60322 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5773 61792-61797 Protein denotes IP-10 https://www.uniprot.org/uniprot/Q96QJ5|https://www.uniprot.org/uniprot/Q8MIZ1|https://www.uniprot.org/uniprot/Q865F5|https://www.uniprot.org/uniprot/Q6GTC7|https://www.uniprot.org/uniprot/P70538|https://www.uniprot.org/uniprot/P48973|https://www.uniprot.org/uniprot/P17515|https://www.uniprot.org/uniprot/P02778
T5781 61799-61804 Protein denotes MCP-1 https://www.uniprot.org/uniprot/Q9UDF3|https://www.uniprot.org/uniprot/Q9TTQ3|https://www.uniprot.org/uniprot/Q9QYD7|https://www.uniprot.org/uniprot/Q9MYN4|https://www.uniprot.org/uniprot/Q549R5|https://www.uniprot.org/uniprot/Q08782|https://www.uniprot.org/uniprot/P61275|https://www.uniprot.org/uniprot/P61274|https://www.uniprot.org/uniprot/P52203|https://www.uniprot.org/uniprot/P42831|https://www.uniprot.org/uniprot/P28292|https://www.uniprot.org/uniprot/P28291|https://www.uniprot.org/uniprot/P14844|https://www.uniprot.org/uniprot/P13500|https://www.uniprot.org/uniprot/P10148|https://www.uniprot.org/uniprot/B2R4V3|https://www.uniprot.org/uniprot/A9QWP7
T5798 61806-61810 Protein denotes IL-4 https://www.uniprot.org/uniprot/Q9XS58|https://www.uniprot.org/uniprot/Q9MZR8|https://www.uniprot.org/uniprot/Q9GL85|https://www.uniprot.org/uniprot/Q95MZ6|https://www.uniprot.org/uniprot/Q8MKE6|https://www.uniprot.org/uniprot/Q8HYB1|https://www.uniprot.org/uniprot/Q865Y0|https://www.uniprot.org/uniprot/Q865X5|https://www.uniprot.org/uniprot/Q7YS71|https://www.uniprot.org/uniprot/Q6YL20|https://www.uniprot.org/uniprot/Q6NZ77|https://www.uniprot.org/uniprot/Q60440|https://www.uniprot.org/uniprot/Q58M18|https://www.uniprot.org/uniprot/Q3S4V6|https://www.uniprot.org/uniprot/Q2PE74|https://www.uniprot.org/uniprot/Q29054|https://www.uniprot.org/uniprot/Q14630|https://www.uniprot.org/uniprot/Q0MS73|https://www.uniprot.org/uniprot/Q0MS70|https://www.uniprot.org/uniprot/Q04745|https://www.uniprot.org/uniprot/P79339|https://www.uniprot.org/uniprot/P79170|https://www.uniprot.org/uniprot/P79155|https://www.uniprot.org/uniprot/P55030|https://www.uniprot.org/uniprot/P51744|https://www.uniprot.org/uniprot/P51492|https://www.uniprot.org/uniprot/P47966|https://www.uniprot.org/uniprot/P46652|https://www.uniprot.org/uniprot/P42202|https://www.uniprot.org/uniprot/P30368|https://www.uniprot.org/uniprot/P30367|https://www.uniprot.org/uniprot/P20096|https://www.uniprot.org/uniprot/P07750|https://www.uniprot.org/uniprot/P05112|https://www.uniprot.org/uniprot/O77762|https://www.uniprot.org/uniprot/O70330|https://www.uniprot.org/uniprot/O62774|https://www.uniprot.org/uniprot/O46393|https://www.uniprot.org/uniprot/A9QWQ7|https://www.uniprot.org/uniprot/A1E293
T5838 61816-61821 Protein denotes IL-10 https://www.uniprot.org/uniprot/Q9Z1Y5|https://www.uniprot.org/uniprot/Q9TSJ7|https://www.uniprot.org/uniprot/Q9TSJ4|https://www.uniprot.org/uniprot/Q9JHK7|https://www.uniprot.org/uniprot/Q8MKG9|https://www.uniprot.org/uniprot/Q865X4|https://www.uniprot.org/uniprot/Q6A2H5|https://www.uniprot.org/uniprot/Q6A2H4|https://www.uniprot.org/uniprot/Q63263|https://www.uniprot.org/uniprot/Q5Q0V6|https://www.uniprot.org/uniprot/Q2PE73|https://www.uniprot.org/uniprot/Q29408|https://www.uniprot.org/uniprot/Q29055|https://www.uniprot.org/uniprot/Q28374|https://www.uniprot.org/uniprot/Q25BC1|https://www.uniprot.org/uniprot/Q1W5D6|https://www.uniprot.org/uniprot/Q0Z972|https://www.uniprot.org/uniprot/Q0VBJ1|https://www.uniprot.org/uniprot/P79338|https://www.uniprot.org/uniprot/P55029|https://www.uniprot.org/uniprot/P51746|https://www.uniprot.org/uniprot/P51497|https://www.uniprot.org/uniprot/P51496|https://www.uniprot.org/uniprot/P48411|https://www.uniprot.org/uniprot/P47965|https://www.uniprot.org/uniprot/P46651|https://www.uniprot.org/uniprot/P43480|https://www.uniprot.org/uniprot/P29456|https://www.uniprot.org/uniprot/P22301|https://www.uniprot.org/uniprot/P18893|https://www.uniprot.org/uniprot/O97798|https://www.uniprot.org/uniprot/O46673|https://www.uniprot.org/uniprot/A9QWR2|https://www.uniprot.org/uniprot/A2T6Z6
T5872 62238-62242 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5873 62326-62330 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5874 63163-63172 Protein denotes protein 3 https://www.uniprot.org/uniprot/Q9JGT9|https://www.uniprot.org/uniprot/Q98663|https://www.uniprot.org/uniprot/Q8V3T9|https://www.uniprot.org/uniprot/Q6UBL8|https://www.uniprot.org/uniprot/Q6Q1S1|https://www.uniprot.org/uniprot/Q6E0W9|https://www.uniprot.org/uniprot/Q68Y30|https://www.uniprot.org/uniprot/Q5GA88|https://www.uniprot.org/uniprot/Q3LZX0|https://www.uniprot.org/uniprot/Q3I5J4|https://www.uniprot.org/uniprot/Q12988|https://www.uniprot.org/uniprot/Q0Q474|https://www.uniprot.org/uniprot/Q02967|https://www.uniprot.org/uniprot/Q00967|https://www.uniprot.org/uniprot/P09522|https://www.uniprot.org/uniprot/P05398|https://www.uniprot.org/uniprot/P03553|https://www.uniprot.org/uniprot/P03552|https://www.uniprot.org/uniprot/P03551
T5893 63208-63217 Protein denotes a protein https://www.uniprot.org/uniprot/Q38365|https://www.uniprot.org/uniprot/P25244|https://www.uniprot.org/uniprot/P25243|https://www.uniprot.org/uniprot/P15966|https://www.uniprot.org/uniprot/P09676|https://www.uniprot.org/uniprot/P07394|https://www.uniprot.org/uniprot/P03632|https://www.uniprot.org/uniprot/P03610|https://www.uniprot.org/uniprot/O64306
T5902 63218-63225 Protein denotes caspase https://www.uniprot.org/uniprot/Q9VAH1|https://www.uniprot.org/uniprot/O01382
T5904 63246-63249 Protein denotes ASC https://www.uniprot.org/uniprot/P50427|https://www.uniprot.org/uniprot/P15589|https://www.uniprot.org/uniprot/P08842|https://www.uniprot.org/uniprot/B2RA47
T5908 63306-63313 Protein denotes caspase https://www.uniprot.org/uniprot/Q9VAH1|https://www.uniprot.org/uniprot/O01382
T5910 63342-63351 Protein denotes caspase 1 https://www.uniprot.org/uniprot/Q9W1N0|https://www.uniprot.org/uniprot/Q9UCN3|https://www.uniprot.org/uniprot/Q9TV13|https://www.uniprot.org/uniprot/Q9N2I1|https://www.uniprot.org/uniprot/Q9MZV7|https://www.uniprot.org/uniprot/Q9MZV6|https://www.uniprot.org/uniprot/Q6PI75|https://www.uniprot.org/uniprot/Q6GSS3|https://www.uniprot.org/uniprot/Q6DMQ1|https://www.uniprot.org/uniprot/Q53EY6|https://www.uniprot.org/uniprot/P89116|https://www.uniprot.org/uniprot/P43527|https://www.uniprot.org/uniprot/P29466|https://www.uniprot.org/uniprot/P29452|https://www.uniprot.org/uniprot/O02002|https://www.uniprot.org/uniprot/B5MDZ1
T5926 63599-63603 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5927 64316-64319 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T5952 64320-64324 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5953 64388-64392 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T5954 64685-64696 Protein denotes disintegrin https://www.uniprot.org/uniprot/Q9YI19|https://www.uniprot.org/uniprot/Q9PVK9|https://www.uniprot.org/uniprot/Q9IAX6|https://www.uniprot.org/uniprot/Q7SZE0|https://www.uniprot.org/uniprot/Q7SZD7|https://www.uniprot.org/uniprot/Q7SZD6|https://www.uniprot.org/uniprot/Q5EE07|https://www.uniprot.org/uniprot/P0DMH4|https://www.uniprot.org/uniprot/P0C6E3|https://www.uniprot.org/uniprot/O73795|https://www.uniprot.org/uniprot/E9NW26
T5965 64721-64728 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T5974 64818-64841 Protein denotes epidermal growth factor https://www.uniprot.org/uniprot/Q9GU69|https://www.uniprot.org/uniprot/Q9BEA0|https://www.uniprot.org/uniprot/Q9BDQ0|https://www.uniprot.org/uniprot/Q95ND4|https://www.uniprot.org/uniprot/Q6P9J2|https://www.uniprot.org/uniprot/Q63183|https://www.uniprot.org/uniprot/Q569W5|https://www.uniprot.org/uniprot/Q52LZ6|https://www.uniprot.org/uniprot/Q00968|https://www.uniprot.org/uniprot/P07522|https://www.uniprot.org/uniprot/P01133|https://www.uniprot.org/uniprot/P01132|https://www.uniprot.org/uniprot/O62759|https://www.uniprot.org/uniprot/E9QNX6|https://www.uniprot.org/uniprot/E9PBF0|https://www.uniprot.org/uniprot/E7EVD2|https://www.uniprot.org/uniprot/B4DRK7
T5991 65011-65018 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6000 65094-65098 Protein denotes IL-6 https://www.uniprot.org/uniprot/Q9XT80|https://www.uniprot.org/uniprot/Q9UCU4|https://www.uniprot.org/uniprot/Q9UCU3|https://www.uniprot.org/uniprot/Q9UCU2|https://www.uniprot.org/uniprot/Q9MZR1|https://www.uniprot.org/uniprot/Q9MYZ7|https://www.uniprot.org/uniprot/Q95KN6|https://www.uniprot.org/uniprot/Q95181|https://www.uniprot.org/uniprot/Q90YI0|https://www.uniprot.org/uniprot/Q8MKH0|https://www.uniprot.org/uniprot/Q8BN26|https://www.uniprot.org/uniprot/Q865X6|https://www.uniprot.org/uniprot/Q865W7|https://www.uniprot.org/uniprot/Q6V919|https://www.uniprot.org/uniprot/Q6L6X6|https://www.uniprot.org/uniprot/Q5I6E3|https://www.uniprot.org/uniprot/Q3UCQ0|https://www.uniprot.org/uniprot/Q2MH06|https://www.uniprot.org/uniprot/Q28819|https://www.uniprot.org/uniprot/Q28747|https://www.uniprot.org/uniprot/Q28319|https://www.uniprot.org/uniprot/Q25BC2|https://www.uniprot.org/uniprot/Q0PW36|https://www.uniprot.org/uniprot/Q0GGL7|https://www.uniprot.org/uniprot/Q08DT2|https://www.uniprot.org/uniprot/P79341|https://www.uniprot.org/uniprot/P51494|https://www.uniprot.org/uniprot/P46650|https://www.uniprot.org/uniprot/P41693|https://www.uniprot.org/uniprot/P41683|https://www.uniprot.org/uniprot/P41323|https://www.uniprot.org/uniprot/P29455|https://www.uniprot.org/uniprot/P26893|https://www.uniprot.org/uniprot/P26892|https://www.uniprot.org/uniprot/P20607|https://www.uniprot.org/uniprot/P08505|https://www.uniprot.org/uniprot/P05231|https://www.uniprot.org/uniprot/O46568|https://www.uniprot.org/uniprot/O35736|https://www.uniprot.org/uniprot/O19007|https://www.uniprot.org/uniprot/B6CKP4|https://www.uniprot.org/uniprot/A9QWQ9|https://www.uniprot.org/uniprot/A3FBE9|https://www.uniprot.org/uniprot/A0S0B0
T6044 65413-65428 Protein denotes angiotensinogen https://www.uniprot.org/uniprot/Q9TSZ0|https://www.uniprot.org/uniprot/Q9GLP7|https://www.uniprot.org/uniprot/Q9GLP6|https://www.uniprot.org/uniprot/Q9GLN8|https://www.uniprot.org/uniprot/Q96F91|https://www.uniprot.org/uniprot/Q16359|https://www.uniprot.org/uniprot/Q16358|https://www.uniprot.org/uniprot/P67886|https://www.uniprot.org/uniprot/P67885|https://www.uniprot.org/uniprot/P20757|https://www.uniprot.org/uniprot/P11859|https://www.uniprot.org/uniprot/P01019|https://www.uniprot.org/uniprot/P01018|https://www.uniprot.org/uniprot/P01017|https://www.uniprot.org/uniprot/P01016|https://www.uniprot.org/uniprot/P01015|https://www.uniprot.org/uniprot/A0A3Q1LGY9
T6061 65531-65535 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6062 65620-65624 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6063 65750-65754 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6064 65874-65881 Protein denotes ADAM 17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6073 65886-65897 Protein denotes disintegrin https://www.uniprot.org/uniprot/Q9YI19|https://www.uniprot.org/uniprot/Q9PVK9|https://www.uniprot.org/uniprot/Q9IAX6|https://www.uniprot.org/uniprot/Q7SZE0|https://www.uniprot.org/uniprot/Q7SZD7|https://www.uniprot.org/uniprot/Q7SZD6|https://www.uniprot.org/uniprot/Q5EE07|https://www.uniprot.org/uniprot/P0DMH4|https://www.uniprot.org/uniprot/P0C6E3|https://www.uniprot.org/uniprot/O73795|https://www.uniprot.org/uniprot/E9NW26
T6084 65988-65992 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6085 66117-66126 Protein denotes embryonic https://www.uniprot.org/uniprot/P02301
T6086 66166-66170 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6087 66172-66175 Protein denotes HEK https://www.uniprot.org/uniprot/Q9H2V4|https://www.uniprot.org/uniprot/Q9H2V3|https://www.uniprot.org/uniprot/P29320
T6090 66176-66180 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6091 66401-66405 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6092 66474-66480 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6101 66537-66564 Protein denotes metalloproteinase inhibitor https://www.uniprot.org/uniprot/Q9DGI0|https://www.uniprot.org/uniprot/Q98TC1|https://www.uniprot.org/uniprot/P29695
T6104 66586-66606 Protein denotes protease inhibitor 1 https://www.uniprot.org/uniprot/C1IC50
T6105 66628-66632 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6106 66774-66778 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6107 66977-66981 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6108 67144-67148 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6109 67226-67232 Protein denotes ADAM17 https://www.uniprot.org/uniprot/Q9Z1K9|https://www.uniprot.org/uniprot/Q9Z0K3|https://www.uniprot.org/uniprot/Q9Z0F8|https://www.uniprot.org/uniprot/Q9R1U4|https://www.uniprot.org/uniprot/Q505A7|https://www.uniprot.org/uniprot/P78536|https://www.uniprot.org/uniprot/O88726|https://www.uniprot.org/uniprot/O77636|https://www.uniprot.org/uniprot/O60226
T6118 68370-68374 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6119 68422-68426 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6120 68599-68603 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6121 68934-68938 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6122 69013-69016 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6147 69074-69078 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6148 69120-69129 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6159 69168-69172 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6160 69215-69219 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6161 69222-69226 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6162 69248-69252 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6163 69772-69776 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6164 70024-70028 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6165 70065-70074 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6176 70130-70134 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6177 70240-70244 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6178 70429-70433 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6179 70529-70533 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6180 70590-70594 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6181 70654-70658 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6182 70805-70809 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6183 71031-71062 Protein denotes angiotensin-converting enzyme 2 https://www.uniprot.org/uniprot/Q9UFZ6|https://www.uniprot.org/uniprot/Q9NRA7|https://www.uniprot.org/uniprot/Q9BYF1|https://www.uniprot.org/uniprot/Q99N71|https://www.uniprot.org/uniprot/Q99N70|https://www.uniprot.org/uniprot/Q8R0I0|https://www.uniprot.org/uniprot/Q86WT0|https://www.uniprot.org/uniprot/Q6UWP0|https://www.uniprot.org/uniprot/Q5RFN1|https://www.uniprot.org/uniprot/Q5EGZ1|https://www.uniprot.org/uniprot/Q58DD0|https://www.uniprot.org/uniprot/Q56NL1|https://www.uniprot.org/uniprot/Q56H28|https://www.uniprot.org/uniprot/Q2PGE2|https://www.uniprot.org/uniprot/C7ECU1
T6198 71141-71144 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6223 71241-71250 Protein denotes S-protein https://www.uniprot.org/uniprot/Q9D080|https://www.uniprot.org/uniprot/Q9BSH7|https://www.uniprot.org/uniprot/Q91X32|https://www.uniprot.org/uniprot/Q8VII4|https://www.uniprot.org/uniprot/Q5SYG4|https://www.uniprot.org/uniprot/P48819|https://www.uniprot.org/uniprot/P29788|https://www.uniprot.org/uniprot/P22458|https://www.uniprot.org/uniprot/P04004|https://www.uniprot.org/uniprot/P01141|https://www.uniprot.org/uniprot/B2R7G0
T6234 72016-72019 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6243 72096-72100 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6244 72123-72126 Protein denotes RBD https://www.uniprot.org/uniprot/Q63492|https://www.uniprot.org/uniprot/Q63491|https://www.uniprot.org/uniprot/Q62815|https://www.uniprot.org/uniprot/Q62691|https://www.uniprot.org/uniprot/Q01542|https://www.uniprot.org/uniprot/P27732|https://www.uniprot.org/uniprot/O09024|https://www.uniprot.org/uniprot/O09023|https://www.uniprot.org/uniprot/O09022
T6253 72210-72214 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6254 72294-72298 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6255 72641-72645 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6256 72724-72728 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6257 72748-72752 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6258 72844-72848 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6259 72886-72896 Protein denotes collectrin https://www.uniprot.org/uniprot/Q9HBJ8|https://www.uniprot.org/uniprot/Q9ESG4|https://www.uniprot.org/uniprot/Q9ESG3|https://www.uniprot.org/uniprot/Q6UW07|https://www.uniprot.org/uniprot/Q6AYY2|https://www.uniprot.org/uniprot/Q3UFF6|https://www.uniprot.org/uniprot/Q0VCT4|https://www.uniprot.org/uniprot/B2R9M1
T6267 72955-72962 Protein denotes insulin https://www.uniprot.org/uniprot/Q9W7R2|https://www.uniprot.org/uniprot/Q9W653|https://www.uniprot.org/uniprot/Q9TSJ5|https://www.uniprot.org/uniprot/Q9TQY8|https://www.uniprot.org/uniprot/Q9TQY7|https://www.uniprot.org/uniprot/Q9PRR2|https://www.uniprot.org/uniprot/Q9PRR1|https://www.uniprot.org/uniprot/Q9NDE7|https://www.uniprot.org/uniprot/Q98TA8|https://www.uniprot.org/uniprot/Q91XI3|https://www.uniprot.org/uniprot/Q91479|https://www.uniprot.org/uniprot/Q91478|https://www.uniprot.org/uniprot/Q91477|https://www.uniprot.org/uniprot/Q8WNW6|https://www.uniprot.org/uniprot/Q8HXV2|https://www.uniprot.org/uniprot/Q6YK33|https://www.uniprot.org/uniprot/Q62587|https://www.uniprot.org/uniprot/Q5EEX2|https://www.uniprot.org/uniprot/Q53YX4|https://www.uniprot.org/uniprot/Q504H9|https://www.uniprot.org/uniprot/Q10995|https://www.uniprot.org/uniprot/P81881|https://www.uniprot.org/uniprot/P81423|https://www.uniprot.org/uniprot/P81025|https://www.uniprot.org/uniprot/P69048|https://www.uniprot.org/uniprot/P69047|https://www.uniprot.org/uniprot/P69046|https://www.uniprot.org/uniprot/P69045|https://www.uniprot.org/uniprot/P68992|https://www.uniprot.org/uniprot/P68991|https://www.uniprot.org/uniprot/P68990|https://www.uniprot.org/uniprot/P68989|https://www.uniprot.org/uniprot/P68988|https://www.uniprot.org/uniprot/P68987|https://www.uniprot.org/uniprot/P68245|https://www.uniprot.org/uniprot/P68243|https://www.uniprot.org/uniprot/P67974|https://www.uniprot.org/uniprot/P67973|https://www.uniprot.org/uniprot/P67972|https://www.uniprot.org/uniprot/P67971|https://www.uniprot.org/uniprot/P67970|https://www.uniprot.org/uniprot/P67969|https://www.uniprot.org/uniprot/P67968|https://www.uniprot.org/uniprot/P51463|https://www.uniprot.org/uniprot/P42633|https://www.uniprot.org/uniprot/P41522|https://www.uniprot.org/uniprot/P31887|https://www.uniprot.org/uniprot/P30410|https://www.uniprot.org/uniprot/P30407|https://www.uniprot.org/uniprot/P30406|https://www.uniprot.org/uniprot/P29335|https://www.uniprot.org/uniprot/P23187|https://www.uniprot.org/uniprot/P21563|https://www.uniprot.org/uniprot/P18109|https://www.uniprot.org/uniprot/P17715|https://www.uniprot.org/uniprot/P14806|https://www.uniprot.org/uniprot/P13190|https://www.uniprot.org/uniprot/P12708|https://www.uniprot.org/uniprot/P12705|https://www.uniprot.org/uniprot/P12704|https://www.uniprot.org/uniprot/P12703|https://www.uniprot.org/uniprot/P10604|https://www.uniprot.org/uniprot/P0C236|https://www.uniprot.org/uniprot/P09536|https://www.uniprot.org/uniprot/P09477|https://www.uniprot.org/uniprot/P09476|https://www.uniprot.org/uniprot/P07454|https://www.uniprot.org/uniprot/P07453|https://www.uniprot.org/uniprot/P06306|https://www.uniprot.org/uniprot/P04667|https://www.uniprot.org/uniprot/P01342|https://www.uniprot.org/uniprot/P01341|https://www.uniprot.org/uniprot/P01340|https://www.uniprot.org/uniprot/P01339|https://www.uniprot.org/uniprot/P01336|https://www.uniprot.org/uniprot/P01335|https://www.uniprot.org/uniprot/P01334|https://www.uniprot.org/uniprot/P01333|https://www.uniprot.org/uniprot/P01332|https://www.uniprot.org/uniprot/P01331|https://www.uniprot.org/uniprot/P01330|https://www.uniprot.org/uniprot/P01329|https://www.uniprot.org/uniprot/P01328|https://www.uniprot.org/uniprot/P01327|https://www.uniprot.org/uniprot/P01324|https://www.uniprot.org/uniprot/P01321|https://www.uniprot.org/uniprot/P01320|https://www.uniprot.org/uniprot/P01319|https://www.uniprot.org/uniprot/P01318|https://www.uniprot.org/uniprot/P01317|https://www.uniprot.org/uniprot/P01316|https://www.uniprot.org/uniprot/P01315|https://www.uniprot.org/uniprot/P01314|https://www.uniprot.org/uniprot/P01313|https://www.uniprot.org/uniprot/P01312|https://www.uniprot.org/uniprot/P01311|https://www.uniprot.org/uniprot/P01310|https://www.uniprot.org/uniprot/P01309|https://www.uniprot.org/uniprot/P01308|https://www.uniprot.org/uniprot/O73727|https://www.uniprot.org/uniprot/O42485|https://www.uniprot.org/uniprot/C0HJU0|https://www.uniprot.org/uniprot/C0HJT9|https://www.uniprot.org/uniprot/C0HJI4|https://www.uniprot.org/uniprot/C0HJI1
T6372 73009-73013 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6373 73115-73119 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6374 73235-73239 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6375 73358-73362 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6376 73392-73399 Protein denotes insulin https://www.uniprot.org/uniprot/Q9W7R2|https://www.uniprot.org/uniprot/Q9W653|https://www.uniprot.org/uniprot/Q9TSJ5|https://www.uniprot.org/uniprot/Q9TQY8|https://www.uniprot.org/uniprot/Q9TQY7|https://www.uniprot.org/uniprot/Q9PRR2|https://www.uniprot.org/uniprot/Q9PRR1|https://www.uniprot.org/uniprot/Q9NDE7|https://www.uniprot.org/uniprot/Q98TA8|https://www.uniprot.org/uniprot/Q91XI3|https://www.uniprot.org/uniprot/Q91479|https://www.uniprot.org/uniprot/Q91478|https://www.uniprot.org/uniprot/Q91477|https://www.uniprot.org/uniprot/Q8WNW6|https://www.uniprot.org/uniprot/Q8HXV2|https://www.uniprot.org/uniprot/Q6YK33|https://www.uniprot.org/uniprot/Q62587|https://www.uniprot.org/uniprot/Q5EEX2|https://www.uniprot.org/uniprot/Q53YX4|https://www.uniprot.org/uniprot/Q504H9|https://www.uniprot.org/uniprot/Q10995|https://www.uniprot.org/uniprot/P81881|https://www.uniprot.org/uniprot/P81423|https://www.uniprot.org/uniprot/P81025|https://www.uniprot.org/uniprot/P69048|https://www.uniprot.org/uniprot/P69047|https://www.uniprot.org/uniprot/P69046|https://www.uniprot.org/uniprot/P69045|https://www.uniprot.org/uniprot/P68992|https://www.uniprot.org/uniprot/P68991|https://www.uniprot.org/uniprot/P68990|https://www.uniprot.org/uniprot/P68989|https://www.uniprot.org/uniprot/P68988|https://www.uniprot.org/uniprot/P68987|https://www.uniprot.org/uniprot/P68245|https://www.uniprot.org/uniprot/P68243|https://www.uniprot.org/uniprot/P67974|https://www.uniprot.org/uniprot/P67973|https://www.uniprot.org/uniprot/P67972|https://www.uniprot.org/uniprot/P67971|https://www.uniprot.org/uniprot/P67970|https://www.uniprot.org/uniprot/P67969|https://www.uniprot.org/uniprot/P67968|https://www.uniprot.org/uniprot/P51463|https://www.uniprot.org/uniprot/P42633|https://www.uniprot.org/uniprot/P41522|https://www.uniprot.org/uniprot/P31887|https://www.uniprot.org/uniprot/P30410|https://www.uniprot.org/uniprot/P30407|https://www.uniprot.org/uniprot/P30406|https://www.uniprot.org/uniprot/P29335|https://www.uniprot.org/uniprot/P23187|https://www.uniprot.org/uniprot/P21563|https://www.uniprot.org/uniprot/P18109|https://www.uniprot.org/uniprot/P17715|https://www.uniprot.org/uniprot/P14806|https://www.uniprot.org/uniprot/P13190|https://www.uniprot.org/uniprot/P12708|https://www.uniprot.org/uniprot/P12705|https://www.uniprot.org/uniprot/P12704|https://www.uniprot.org/uniprot/P12703|https://www.uniprot.org/uniprot/P10604|https://www.uniprot.org/uniprot/P0C236|https://www.uniprot.org/uniprot/P09536|https://www.uniprot.org/uniprot/P09477|https://www.uniprot.org/uniprot/P09476|https://www.uniprot.org/uniprot/P07454|https://www.uniprot.org/uniprot/P07453|https://www.uniprot.org/uniprot/P06306|https://www.uniprot.org/uniprot/P04667|https://www.uniprot.org/uniprot/P01342|https://www.uniprot.org/uniprot/P01341|https://www.uniprot.org/uniprot/P01340|https://www.uniprot.org/uniprot/P01339|https://www.uniprot.org/uniprot/P01336|https://www.uniprot.org/uniprot/P01335|https://www.uniprot.org/uniprot/P01334|https://www.uniprot.org/uniprot/P01333|https://www.uniprot.org/uniprot/P01332|https://www.uniprot.org/uniprot/P01331|https://www.uniprot.org/uniprot/P01330|https://www.uniprot.org/uniprot/P01329|https://www.uniprot.org/uniprot/P01328|https://www.uniprot.org/uniprot/P01327|https://www.uniprot.org/uniprot/P01324|https://www.uniprot.org/uniprot/P01321|https://www.uniprot.org/uniprot/P01320|https://www.uniprot.org/uniprot/P01319|https://www.uniprot.org/uniprot/P01318|https://www.uniprot.org/uniprot/P01317|https://www.uniprot.org/uniprot/P01316|https://www.uniprot.org/uniprot/P01315|https://www.uniprot.org/uniprot/P01314|https://www.uniprot.org/uniprot/P01313|https://www.uniprot.org/uniprot/P01312|https://www.uniprot.org/uniprot/P01311|https://www.uniprot.org/uniprot/P01310|https://www.uniprot.org/uniprot/P01309|https://www.uniprot.org/uniprot/P01308|https://www.uniprot.org/uniprot/O73727|https://www.uniprot.org/uniprot/O42485|https://www.uniprot.org/uniprot/C0HJU0|https://www.uniprot.org/uniprot/C0HJT9|https://www.uniprot.org/uniprot/C0HJI4|https://www.uniprot.org/uniprot/C0HJI1
T6481 73479-73483 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6482 73629-73633 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6483 73697-73701 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6484 73716-73720 Protein denotes Beta https://www.uniprot.org/uniprot/Q66765|https://www.uniprot.org/uniprot/Q66764|https://www.uniprot.org/uniprot/Q2V6G9|https://www.uniprot.org/uniprot/Q155Z9|https://www.uniprot.org/uniprot/P32540|https://www.uniprot.org/uniprot/P17594|https://www.uniprot.org/uniprot/P17593|https://www.uniprot.org/uniprot/P12296|https://www.uniprot.org/uniprot/P03304|https://www.uniprot.org/uniprot/C0MHL9|https://www.uniprot.org/uniprot/B8XTP8
T6495 73848-73852 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6496 74136-74140 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6497 74203-74207 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6498 74318-74322 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6499 74489-74493 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6500 74521-74531 Protein denotes E-cadherin https://www.uniprot.org/uniprot/Q9UII8|https://www.uniprot.org/uniprot/Q9R0T4|https://www.uniprot.org/uniprot/Q9JIV9|https://www.uniprot.org/uniprot/Q91709|https://www.uniprot.org/uniprot/Q6R8F2|https://www.uniprot.org/uniprot/Q61377|https://www.uniprot.org/uniprot/Q5RAX1|https://www.uniprot.org/uniprot/Q4PJ14|https://www.uniprot.org/uniprot/Q16194|https://www.uniprot.org/uniprot/Q15855|https://www.uniprot.org/uniprot/Q14216|https://www.uniprot.org/uniprot/Q13799|https://www.uniprot.org/uniprot/P30944|https://www.uniprot.org/uniprot/P12830|https://www.uniprot.org/uniprot/P09803|https://www.uniprot.org/uniprot/P08641|https://www.uniprot.org/uniprot/O35794|https://www.uniprot.org/uniprot/F1PAA9|https://www.uniprot.org/uniprot/A8K1U7
T6519 74575-74583 Protein denotes vimentin https://www.uniprot.org/uniprot/Q9NTM3|https://www.uniprot.org/uniprot/Q9MZA9|https://www.uniprot.org/uniprot/Q96ML2|https://www.uniprot.org/uniprot/Q92155|https://www.uniprot.org/uniprot/Q91023|https://www.uniprot.org/uniprot/Q8N850|https://www.uniprot.org/uniprot/Q8CCH1|https://www.uniprot.org/uniprot/Q6LER9|https://www.uniprot.org/uniprot/Q5R1W8|https://www.uniprot.org/uniprot/Q548L2|https://www.uniprot.org/uniprot/Q4R4X4|https://www.uniprot.org/uniprot/Q3HWE4|https://www.uniprot.org/uniprot/Q17QM7|https://www.uniprot.org/uniprot/Q15869|https://www.uniprot.org/uniprot/Q15868|https://www.uniprot.org/uniprot/Q15867|https://www.uniprot.org/uniprot/P84198|https://www.uniprot.org/uniprot/P48674|https://www.uniprot.org/uniprot/P48670|https://www.uniprot.org/uniprot/P48616|https://www.uniprot.org/uniprot/P31000|https://www.uniprot.org/uniprot/P20152|https://www.uniprot.org/uniprot/P09654|https://www.uniprot.org/uniprot/P08670|https://www.uniprot.org/uniprot/P02544|https://www.uniprot.org/uniprot/P02543|https://www.uniprot.org/uniprot/O08704|https://www.uniprot.org/uniprot/F1RWC0|https://www.uniprot.org/uniprot/F1RWB8|https://www.uniprot.org/uniprot/D3DRU4|https://www.uniprot.org/uniprot/B0YJC2|https://www.uniprot.org/uniprot/A5A6N8
T6551 74890-74894 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6552 75060-75064 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6553 75147-75151 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6554 75205-75209 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6555 75472-75476 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6556 75550-75554 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6557 75706-75710 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6558 75791-75795 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6559 75877-75881 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6560 75936-75940 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6561 76109-76113 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6562 76243-76247 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6563 76428-76432 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6564 76566-76570 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6565 76683-76687 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6566 76710-76713 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6591 76753-76756 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6616 76906-76910 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6617 77070-77073 Protein denotes ACE https://www.uniprot.org/uniprot/Q9GLN7|https://www.uniprot.org/uniprot/Q9GLN6|https://www.uniprot.org/uniprot/Q9EQM9|https://www.uniprot.org/uniprot/Q8CFN1|https://www.uniprot.org/uniprot/Q7TMC6|https://www.uniprot.org/uniprot/Q7M4L4|https://www.uniprot.org/uniprot/Q6GTS2|https://www.uniprot.org/uniprot/Q59GY8|https://www.uniprot.org/uniprot/Q53YX9|https://www.uniprot.org/uniprot/Q50JE5|https://www.uniprot.org/uniprot/Q10751|https://www.uniprot.org/uniprot/Q0GA41|https://www.uniprot.org/uniprot/P47820|https://www.uniprot.org/uniprot/P22968|https://www.uniprot.org/uniprot/P22967|https://www.uniprot.org/uniprot/P22966|https://www.uniprot.org/uniprot/P12822|https://www.uniprot.org/uniprot/P12821|https://www.uniprot.org/uniprot/P12820|https://www.uniprot.org/uniprot/P09470|https://www.uniprot.org/uniprot/O02852|https://www.uniprot.org/uniprot/E7EU16|https://www.uniprot.org/uniprot/B4DXI3|https://www.uniprot.org/uniprot/B0LPF0|https://www.uniprot.org/uniprot/Q9VJV3
T6642 77164-77168 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6643 77376-77380 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6644 77631-77635 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6645 77645-77663 Protein denotes spike glycoprotein https://www.uniprot.org/uniprot/Q9QAS2|https://www.uniprot.org/uniprot/Q9QAR5|https://www.uniprot.org/uniprot/Q9QAQ8|https://www.uniprot.org/uniprot/Q9IW04|https://www.uniprot.org/uniprot/Q9IKD1|https://www.uniprot.org/uniprot/Q990M4|https://www.uniprot.org/uniprot/Q990M3|https://www.uniprot.org/uniprot/Q990M2|https://www.uniprot.org/uniprot/Q990M1|https://www.uniprot.org/uniprot/Q91AV1|https://www.uniprot.org/uniprot/Q91A26|https://www.uniprot.org/uniprot/Q8V436|https://www.uniprot.org/uniprot/Q8JSP8|https://www.uniprot.org/uniprot/Q8BB25|https://www.uniprot.org/uniprot/Q86623|https://www.uniprot.org/uniprot/Q85088|https://www.uniprot.org/uniprot/Q85087|https://www.uniprot.org/uniprot/Q82706|https://www.uniprot.org/uniprot/Q82683|https://www.uniprot.org/uniprot/Q80BV6|https://www.uniprot.org/uniprot/Q7TFB1|https://www.uniprot.org/uniprot/Q7TFA2|https://www.uniprot.org/uniprot/Q7TA19|https://www.uniprot.org/uniprot/Q7T6T3|https://www.uniprot.org/uniprot/Q7T696|https://www.uniprot.org/uniprot/Q77NC4|https://www.uniprot.org/uniprot/Q6TNF9|https://www.uniprot.org/uniprot/Q6R1L7|https://www.uniprot.org/uniprot/Q6QU82|https://www.uniprot.org/uniprot/Q6Q1S2|https://www.uniprot.org/uniprot/Q696Q6|https://www.uniprot.org/uniprot/Q66291|https://www.uniprot.org/uniprot/Q66290|https://www.uniprot.org/uniprot/Q66199|https://www.uniprot.org/uniprot/Q66177|https://www.uniprot.org/uniprot/Q66176|https://www.uniprot.org/uniprot/Q66174|https://www.uniprot.org/uniprot/Q65984|https://www.uniprot.org/uniprot/Q5MQD0|https://www.uniprot.org/uniprot/Q5I5X9|https://www.uniprot.org/uniprot/Q5DIY0|https://www.uniprot.org/uniprot/Q5DIX9|https://www.uniprot.org/uniprot/Q5DIX8|https://www.uniprot.org/uniprot/Q5DIX7|https://www.uniprot.org/uniprot/Q52PA3|https://www.uniprot.org/uniprot/Q4ZJS1|https://www.uniprot.org/uniprot/Q4U5G0|https://www.uniprot.org/uniprot/Q3T8J0|https://www.uniprot.org/uniprot/Q3LZX1|https://www.uniprot.org/uniprot/Q3I5J5|https://www.uniprot.org/uniprot/Q14EB0|https://www.uniprot.org/uniprot/Q0ZME7|https://www.uniprot.org/uniprot/Q0Q4F2|https://www.uniprot.org/uniprot/Q0Q475|https://www.uniprot.org/uniprot/Q0Q466|https://www.uniprot.org/uniprot/Q0GNB8|https://www.uniprot.org/uniprot/Q02385|https://www.uniprot.org/uniprot/Q02167|https://www.uniprot.org/uniprot/Q01977|https://www.uniprot.org/uniprot/Q008X4|https://www.uniprot.org/uniprot/P89344|https://www.uniprot.org/uniprot/P89343|https://www.uniprot.org/uniprot/P89342|https://www.uniprot.org/uniprot/P59594|https://www.uniprot.org/uniprot/P36334|https://www.uniprot.org/uniprot/P36300|https://www.uniprot.org/uniprot/P33470|https://www.uniprot.org/uniprot/P30208|https://www.uniprot.org/uniprot/P30207|https://www.uniprot.org/uniprot/P30206|https://www.uniprot.org/uniprot/P27662|https://www.uniprot.org/uniprot/P27655|https://www.uniprot.org/uniprot/P27277|https://www.uniprot.org/uniprot/P25194|https://www.uniprot.org/uniprot/P25193|https://www.uniprot.org/uniprot/P25192|https://www.uniprot.org/uniprot/P25191|https://www.uniprot.org/uniprot/P25190|https://www.uniprot.org/uniprot/P24413|https://www.uniprot.org/uniprot/P23052|https://www.uniprot.org/uniprot/P22432|https://www.uniprot.org/uniprot/P18450|https://www.uniprot.org/uniprot/P17662|https://www.uniprot.org/uniprot/P15777|https://www.uniprot.org/uniprot/P15423|https://www.uniprot.org/uniprot/P12722|https://www.uniprot.org/uniprot/P12651|https://www.uniprot.org/uniprot/P12650|https://www.uniprot.org/uniprot/P12647|https://www.uniprot.org/uniprot/P11225|https://www.uniprot.org/uniprot/P11224|https://www.uniprot.org/uniprot/P11223|https://www.uniprot.org/uniprot/P10033|https://www.uniprot.org/uniprot/P0DTC2|https://www.uniprot.org/uniprot/P07946|https://www.uniprot.org/uniprot/P07923|https://www.uniprot.org/uniprot/P05135|https://www.uniprot.org/uniprot/P05134|https://www.uniprot.org/uniprot/O90304|https://www.uniprot.org/uniprot/O39227|https://www.uniprot.org/uniprot/K9N5Q8|https://www.uniprot.org/uniprot/A3EXG6|https://www.uniprot.org/uniprot/A3EXD0|https://www.uniprot.org/uniprot/A3EX94
T6749 77784-77788 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6750 77817-77821 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6751 77981-77985 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6752 78143-78147 Protein denotes ACE2 https://www.uniprot.org/uniprot/Q9UFZ6
T6753 78746-78749 Protein denotes PRA https://www.uniprot.org/uniprot/Q5RHS4|https://www.uniprot.org/uniprot/P06703|https://www.uniprot.org/uniprot/D3DV39

LitCovid-sample-PD-IDO

Id Subject Object Predicate Lexical cue
T1 931-938 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T2 1255-1259 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T3 1325-1329 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T4 1330-1334 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T5 1417-1430 http://purl.obolibrary.org/obo/IDO_0000450 denotes pathogenicity
T6 1637-1646 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T7 1843-1852 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T8 2114-2119 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T9 2130-2141 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T10 2246-2251 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T11 2516-2523 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T12 2971-2978 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T13 3645-3650 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T14 3782-3787 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 3941-3945 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T16 4020-4034 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T17 4164-4170 http://purl.obolibrary.org/obo/BFO_0000030 denotes object
T18 5321-5329 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T19 5996-6001 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T20 6902-6907 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T21 7654-7662 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T22 7777-7785 http://purl.obolibrary.org/obo/BFO_0000034 denotes Function
T23 8150-8164 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T24 8200-8207 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T25 8497-8505 http://purl.obolibrary.org/obo/IDO_0000607 denotes products
T26 9179-9186 http://purl.obolibrary.org/obo/IDO_0000531 denotes hosting
T27 9487-9491 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T28 11357-11365 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T29 11695-11700 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T30 11846-11860 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T31 11882-11890 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T32 11927-11936 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T33 14835-14842 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T34 15340-15345 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T35 15364-15368 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T36 15615-15623 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Diseases
T37 15782-15788 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T38 16472-16477 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T39 16732-16737 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T40 17125-17129 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T41 17366-17374 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T42 18874-18879 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T43 19045-19051 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T44 19203-19208 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T45 19331-19336 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T46 19665-19671 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T47 19761-19766 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T48 19767-19772 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T49 20131-20136 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T50 20804-20809 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T51 21165-21170 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T52 21498-21502 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T53 21645-21654 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T54 21831-21836 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T55 22511-22516 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T56 22833-22839 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T57 23382-23390 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T58 23431-23436 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T59 23471-23476 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T60 23801-23810 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T61 24382-24394 http://purl.obolibrary.org/obo/GO_0000003 denotes reproductive
T62 24466-24471 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T63 24509-24517 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T64 24687-24692 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T65 24901-24906 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T66 25074-25078 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T67 25125-25129 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T68 25169-25174 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T69 25295-25300 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T70 25358-25363 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T71 25458-25463 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T72 25475-25481 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T73 25603-25607 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T74 26616-26621 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T75 27540-27546 http://purl.obolibrary.org/obo/OBI_0100026 denotes organs
T76 27887-27897 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T77 27972-27976 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T78 27977-27983 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T79 28222-28227 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T80 29109-29116 http://purl.obolibrary.org/obo/IDO_0000607 denotes product
T81 29370-29375 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T82 29498-29504 http://purl.obolibrary.org/obo/IDO_0000636 denotes sepsis
T83 30774-30779 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T84 30831-30836 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T85 30927-30934 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T86 31248-31256 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T87 31268-31274 http://purl.obolibrary.org/obo/IDO_0000636 denotes sepsis
T88 31319-31324 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T89 31325-31335 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T90 31475-31484 http://purl.obolibrary.org/obo/IDO_0000552 denotes endotoxin
T91 31514-31520 http://purl.obolibrary.org/obo/IDO_0000636 denotes sepsis
T92 31640-31645 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T93 31689-31697 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T94 32097-32102 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T95 32471-32477 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T96 32665-32673 http://purl.obolibrary.org/obo/BFO_0000034 denotes function
T97 33091-33105 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T98 33226-33234 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T99 33256-33263 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T100 33478-33487 http://purl.obolibrary.org/obo/IDO_0000464 denotes infective
T101 33488-33495 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T102 33669-33677 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T103 33718-33723 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T104 33807-33812 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T105 33991-33995 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T106 33996-34001 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T107 34080-34084 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T108 34133-34141 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T109 34164-34168 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T110 34239-34244 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T111 34376-34386 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T112 34472-34480 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T113 34522-34530 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T114 34735-34742 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T115 34780-34787 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T116 34813-34825 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T117 35102-35106 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T118 35107-35116 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T119 35688-35693 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T120 36103-36107 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T121 36251-36256 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T122 36328-36332 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T123 36389-36396 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T124 36489-36499 http://purl.obolibrary.org/obo/BFO_0000034 denotes Functional
T125 36731-36735 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T126 36897-36907 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T127 37564-37568 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T128 37569-37573 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T129 38043-38050 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T130 38067-38071 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T131 38072-38076 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T132 38133-38138 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T133 38151-38157 http://purl.obolibrary.org/obo/IDO_0000586 denotes infect
T134 38158-38162 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T135 38351-38355 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T136 38370-38381 http://purl.obolibrary.org/obo/IDO_0000464 denotes infected by
T137 38370-38378 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T138 38618-38623 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T139 38733-38737 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T140 38766-38773 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T141 38982-38986 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T142 39350-39355 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T143 39787-39791 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T144 40084-40088 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T145 40099-40103 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T146 40582-40586 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T147 40587-40591 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T148 40904-40908 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T149 40909-40913 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T150 41094-41099 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T151 41108-41112 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T152 41113-41117 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T153 41482-41487 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 41511-41515 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T155 41536-41541 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T156 41556-41560 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T157 41561-41565 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T158 41689-41693 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T159 42090-42094 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T160 42580-42584 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T161 42585-42589 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T162 42659-42664 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T163 42902-42906 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T164 43211-43215 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T165 43506-43510 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T166 43511-43515 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T167 43560-43565 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T168 43749-43753 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T169 43800-43808 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T170 44062-44066 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T171 44097-44102 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T172 44113-44118 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T173 44127-44134 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T174 44217-44224 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T175 44259-44263 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T176 44276-44283 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T177 44335-44339 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T178 44414-44418 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T179 44502-44509 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T180 44560-44565 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T181 44578-44582 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T182 44716-44721 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T183 44826-44833 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T184 44907-44911 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T185 44997-45001 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T186 45002-45006 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T187 45539-45543 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T188 45559-45564 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T189 45748-45753 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T190 47834-47839 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T191 48340-48344 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T192 48657-48661 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T193 48779-48783 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T194 48784-48789 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T195 48860-48866 http://www.geneontology.org/formats/oboInOwl#Subset denotes subset
T196 49504-49508 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T197 52513-52517 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T198 52565-52569 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T199 52600-52604 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T200 52634-52639 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T201 52652-52665 http://purl.obolibrary.org/obo/IDO_0000450 denotes pathogenicity
T202 52805-52809 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T203 52900-52909 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T204 53103-53107 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T205 53374-53379 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T206 53640-53646 http://purl.obolibrary.org/obo/IDO_0000586 denotes infect
T207 54177-54185 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T208 54223-54231 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T209 54527-54535 http://purl.obolibrary.org/obo/IDO_0000586 denotes infected
T210 54676-54684 http://purl.obolibrary.org/obo/OGMS_0000031 denotes diseases
T211 54747-54754 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T212 54871-54878 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T213 54989-54996 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T214 55139-55146 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Disease
T215 55437-55444 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T216 55769-55774 http://purl.obolibrary.org/obo/OBI_0100026 denotes organ
T217 56607-56616 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T218 57784-57793 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T219 57928-57937 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T220 57942-57949 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T221 58187-58194 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T222 58495-58499 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T223 58536-58545 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T224 58690-58695 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T225 58706-58715 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T226 59012-59020 http://purl.obolibrary.org/obo/TRANS_0000002 denotes indirect
T227 59046-59055 http://purl.obolibrary.org/obo/BFO_0000030 denotes objective
T228 59948-59957 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T229 59967-59972 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T230 60060-60064 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T231 60405-60415 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T232 60781-60788 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T233 61154-61163 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T234 61463-61467 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T235 61475-61484 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T236 61764-61774 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T237 62133-62140 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T238 62305-62310 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T239 62365-62376 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T240 62380-62391 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptible
T241 62392-62397 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T242 62427-62432 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T243 62443-62448 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T244 62467-62472 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T245 62658-62662 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T246 62684-62695 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T247 62786-62790 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T248 62922-62930 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T249 62942-62946 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T250 62947-62951 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T251 62985-62993 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T252 63009-63017 http://purl.obolibrary.org/obo/IDO_0000528 denotes pathogen
T253 63111-63115 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T254 63436-63440 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T255 63698-63707 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T256 63826-63836 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T257 63959-63969 http://purl.obolibrary.org/obo/TRANS_0000002 denotes indirectly
T258 64412-64417 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T259 64804-64814 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T260 64828-64834 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T261 64866-64876 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T262 65042-65052 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T263 66134-66139 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T264 66246-66256 http://purl.obolibrary.org/obo/IDO_0000607 denotes production
T265 66493-66498 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T266 66711-66720 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T267 66832-66837 http://purl.obolibrary.org/obo/CL_0000000 denotes cells
T268 66849-66853 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T269 67194-67203 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T270 67447-67461 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility
T271 68020-68030 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T272 68099-68109 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T273 68613-68622 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T274 68712-68716 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T275 68717-68721 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T276 68749-68760 http://purl.obolibrary.org/obo/IDO_0000608 denotes replication
T277 68948-68957 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T278 69151-69155 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T279 69784-69788 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T280 69960-69964 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T281 69965-69969 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T282 70039-70043 http://purl.obolibrary.org/obo/BFO_0000029 denotes site
T283 70262-70267 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T284 70297-70307 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections
T285 70674-70683 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T286 70737-70742 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T287 70761-70778 http://purl.obolibrary.org/obo/GO_0044409 denotes entry in the host
T288 70774-70778 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T289 70779-70783 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T290 71266-71270 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T291 71786-71799 http://purl.obolibrary.org/obo/IDO_0000586 denotes infections in
T292 71817-71822 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T293 72036-72040 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T294 72417-72422 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T295 72443-72462 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T296 72458-72462 http://purl.obolibrary.org/obo/IDO_0000531 denotes host
T297 72501-72506 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T298 72603-72612 http://purl.obolibrary.org/obo/IDO_0000586 denotes infection
T299 72739-72747 http://purl.obolibrary.org/obo/OGMS_0000031 denotes Diseases
T300 73050-73057 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T301 73553-73558 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T302 73659-73666 http://purl.obolibrary.org/obo/OGMS_0000031 denotes disease
T303 73881-73885 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T304 73886-73892 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T305 74339-74345 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T306 74400-74404 http://purl.obolibrary.org/obo/CL_0000000 denotes Cell
T307 74781-74789 http://purl.obolibrary.org/obo/OGMS_0000020 denotes symptoms
T308 75117-75122 http://purl.obolibrary.org/obo/BFO_0000029 denotes sites
T309 75307-75311 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T310 75522-75526 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T311 75620-75624 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T312 76742-76749 http://purl.obolibrary.org/obo/IDO_0000607 denotes product
T313 76826-76836 http://purl.obolibrary.org/obo/BFO_0000034 denotes functional
T314 76991-76996 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T315 77151-77160 http://purl.obolibrary.org/obo/BFO_0000034 denotes functions
T316 77480-77487 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T317 77800-77804 http://purl.obolibrary.org/obo/CL_0000000 denotes cell
T318 77916-77930 http://purl.obolibrary.org/obo/IDO_0000467 denotes susceptibility

LitCovid-sample-PD-FMA

Id Subject Object Predicate Lexical cue fma_id
T1 277-281 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T2 532-547 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T3 554-561 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T4 593-600 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T5 621-642 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T6 644-650 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T7 656-665 Body_part denotes intestine http://purl.org/sig/ont/fma/fma7199
T8 690-707 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T9 1181-1188 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10 1330-1343 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T11 1330-1334 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 1370-1376 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T13 1966-1974 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T14 2692-2700 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T15 3030-3035 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T16 3668-3680 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T17 3941-3945 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T18 4208-4212 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T19 4940-4944 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T20 5012-5019 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T21 5647-5658 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T22 5996-6001 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T23 7014-7019 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T24 7160-7165 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T25 7404-7411 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T26 7478-7483 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T27 7495-7501 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T28 7752-7758 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T29 7821-7825 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T30 7850-7860 Body_part denotes chromosome http://purl.org/sig/ont/fma/fma67093
T31 7888-7892 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T32 7912-7922 Body_part denotes chromosome http://purl.org/sig/ont/fma/fma67093
T33 7994-7998 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T34 8284-8288 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T35 8341-8352 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T36 8565-8575 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T37 9170-9177 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 9868-9878 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T39 10195-10202 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T40 10225-10236 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T41 10791-10795 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T42 10803-10815 Body_part denotes X chromosome http://purl.org/sig/ont/fma/fma84055
T43 10920-10932 Body_part denotes X chromosome http://purl.org/sig/ont/fma/fma84055
T44 11037-11048 Body_part denotes chromosomes http://purl.org/sig/ont/fma/fma67093
T45 11113-11120 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T46 11164-11168 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T47 11187-11193 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T48 11541-11547 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T49 11651-11657 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T50 11684-11700 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T51 11695-11700 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T52 11804-11808 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T53 12104-12110 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T54 12163-12170 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T55 12476-12484 Body_part denotes Estrogen http://purl.org/sig/ont/fma/fma83376
T56 12590-12598 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T57 12742-12748 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T58 12814-12822 Body_part denotes Estrogen http://purl.org/sig/ont/fma/fma83376
T59 12888-12896 Body_part denotes estrogen http://purl.org/sig/ont/fma/fma83376
T60 13095-13104 Body_part denotes estrogens http://purl.org/sig/ont/fma/fma83376
T61 13206-13213 Body_part denotes histone http://purl.org/sig/ont/fma/fma74413
T62 13389-13396 Body_part denotes histone http://purl.org/sig/ont/fma/fma74413
T63 13641-13645 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T64 13693-13701 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T65 13835-13839 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T66 13916-13919 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T67 13978-13981 Body_part denotes H2A http://purl.org/sig/ont/fma/fma84129
T68 13982-13990 Body_part denotes histones http://purl.org/sig/ont/fma/fma74413
T69 14038-14042 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T70 14095-14104 Body_part denotes chromatin http://purl.org/sig/ont/fma/fma67526
T71 14183-14190 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T72 14424-14433 Body_part denotes Chromatin http://purl.org/sig/ont/fma/fma67526
T73 14830-14834 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T74 14878-14882 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T75 14905-14912 Body_part denotes Histone http://purl.org/sig/ont/fma/fma74413
T76 15249-15252 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T77 15324-15328 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T78 15329-15345 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T79 15340-15345 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T80 15364-15368 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T81 15409-15413 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T82 15414-15420 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T83 15764-15768 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T84 15897-15901 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T85 16350-16358 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T86 16460-16477 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T87 16472-16477 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T88 16494-16503 Body_part denotes chromatin http://purl.org/sig/ont/fma/fma67526
T89 16649-16654 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T90 16689-16693 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T91 16957-16961 Body_part denotes mRNA http://purl.org/sig/ont/fma/fma67122
T92 17125-17138 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T93 17125-17129 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T94 17519-17529 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T95 17582-17592 Body_part denotes calmodulin http://purl.org/sig/ont/fma/fma62343
T96 17843-17849 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T97 18356-18362 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T98 18414-18421 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T99 18461-18468 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T100 18562-18583 Body_part denotes cardiovascular system http://purl.org/sig/ont/fma/fma7161
T101 18588-18594 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T102 18732-18739 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T103 18797-18808 Body_part denotes vasculature http://purl.org/sig/ont/fma/fma69050
T104 18830-18838 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T105 18843-18848 Body_part denotes veins http://purl.org/sig/ont/fma/fma63814
T106 18860-18879 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T107 18874-18879 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T108 18904-18915 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T109 19113-19124 Body_part denotes capillaries http://purl.org/sig/ont/fma/fma63194
T110 19172-19176 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T111 19191-19208 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T112 19203-19208 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T113 19251-19257 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T114 19271-19279 Body_part denotes arteries http://purl.org/sig/ont/fma/fma63812
T115 19317-19336 Body_part denotes smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T116 19331-19336 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T117 19344-19349 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T118 19405-19414 Body_part denotes mesangium http://purl.org/sig/ont/fma/fma84139
T119 19430-19441 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T120 19449-19455 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T121 19491-19500 Body_part denotes sinusoids http://purl.org/sig/ont/fma/fma63131
T122 19508-19513 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T123 19621-19637 Body_part denotes lymphatic system http://purl.org/sig/ont/fma/fma7162
T124 19679-19685 Body_part denotes spleen http://purl.org/sig/ont/fma/fma7196
T125 19687-19698 Body_part denotes lymph nodes http://purl.org/sig/ont/fma/fma5034
T126 19687-19692 Body_part denotes lymph http://purl.org/sig/ont/fma/fma9671
T127 19704-19715 Body_part denotes bone marrow http://purl.org/sig/ont/fma/fma9608
T128 19761-19766 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T129 19767-19772 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T130 19798-19807 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T131 19812-19823 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T132 19842-19855 Body_part denotes T lymphocytes http://purl.org/sig/ont/fma/fma62870
T133 19961-19966 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T134 20097-20111 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T135 20131-20136 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T136 20144-20159 Body_part denotes sinoatrial node http://purl.org/sig/ont/fma/fma9477
T137 20259-20264 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T138 20328-20341 Body_part denotes aortic valves http://purl.org/sig/ont/fma/fma7236
T139 20392-20406 Body_part denotes myofibroblasts http://purl.org/sig/ont/fma/fma0326458
T140 20411-20422 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T141 20463-20470 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T142 20532-20538 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T143 20767-20779 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T144 20804-20809 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T145 20877-20889 Body_part denotes Henle’s loop http://purl.org/sig/ont/fma/fma17698
T146 20922-20926 Body_part denotes duct http://purl.org/sig/ont/fma/fma30320
T147 21077-21094 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T148 21191-21202 Body_part denotes oral mucosa http://purl.org/sig/ont/fma/fma59660
T149 21196-21202 Body_part denotes mucosa http://purl.org/sig/ont/fma/fma85355
T150 21211-21217 Body_part denotes larynx http://purl.org/sig/ont/fma/fma55097
T151 21219-21226 Body_part denotes trachea http://purl.org/sig/ont/fma/fma7394
T152 21240-21244 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T153 21315-21325 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T154 21474-21478 Body_part denotes face http://purl.org/sig/ont/fma/fma24728
T155 21498-21502 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T156 21503-21506 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T157 21615-21622 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T158 21729-21752 Body_part denotes upper respiratory tract http://purl.org/sig/ont/fma/fma45661
T159 21800-21814 Body_part denotes lamina propria http://purl.org/sig/ont/fma/fma62517
T160 21824-21836 Body_part denotes muscle cells http://purl.org/sig/ont/fma/fma67328
T161 21831-21836 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T162 21848-21867 Body_part denotes salivary gland duct http://purl.org/sig/ont/fma/fma59908
T163 21868-21878 Body_part denotes epithelium http://purl.org/sig/ont/fma/fma9639
T164 21887-21891 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T165 21920-21927 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T166 21976-21987 Body_part denotes pneumocytes http://purl.org/sig/ont/fma/fma62499
T167 22409-22414 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T168 22460-22471 Body_part denotes endothelium http://purl.org/sig/ont/fma/fma63916
T169 22490-22499 Body_part denotes bile duct http://purl.org/sig/ont/fma/fma9706
T170 22500-22516 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T171 22511-22516 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T172 22561-22572 Body_part denotes hepatocytes http://purl.org/sig/ont/fma/fma14515
T173 22642-22649 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T174 22681-22693 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T175 22697-22708 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T176 22729-22744 Body_part denotes small intestine http://purl.org/sig/ont/fma/fma7200
T177 22760-22768 Body_part denotes duodenum http://purl.org/sig/ont/fma/fma7206
T178 22770-22777 Body_part denotes jejunum http://purl.org/sig/ont/fma/fma7207
T179 22783-22788 Body_part denotes ileum http://purl.org/sig/ont/fma/fma7208
T180 22801-22812 Body_part denotes enterocytes http://purl.org/sig/ont/fma/fma62122
T181 22820-22825 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T182 22847-22862 Body_part denotes digestive tract http://purl.org/sig/ont/fma/fma317863
T183 22876-22883 Body_part denotes stomach http://purl.org/sig/ont/fma/fma7148
T184 22888-22893 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T185 22908-22920 Body_part denotes brush border http://purl.org/sig/ont/fma/fma70977
T186 22978-22985 Body_part denotes mucosae http://purl.org/sig/ont/fma/fma85355
T187 23114-23120 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T188 23142-23162 Body_part denotes islets of Langerhans http://purl.org/sig/ont/fma/fma76489
T189 23249-23254 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T190 23265-23278 Body_part denotes telencephalon http://purl.org/sig/ont/fma/fma62000
T191 23286-23293 Body_part denotes medulla http://purl.org/sig/ont/fma/fma61108
T192 23325-23330 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T193 23422-23457 Body_part denotes vascular organ of lamina terminalis http://purl.org/sig/ont/fma/fma62315
T194 23459-23476 Body_part denotes subfornical organ http://purl.org/sig/ont/fma/fma75260
T195 23492-23499 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T196 23520-23543 Body_part denotes paraventricular nucleus http://purl.org/sig/ont/fma/fma62320
T197 23545-23558 Body_part denotes area postrema http://purl.org/sig/ont/fma/fma72607
T198 23560-23589 Body_part denotes nucleus of the solitary tract http://purl.org/sig/ont/fma/fma256691
T199 23575-23589 Body_part denotes solitary tract http://purl.org/sig/ont/fma/fma72619
T200 23619-23624 Body_part denotes vagus http://purl.org/sig/ont/fma/fma5731
T201 23671-23678 Body_part denotes medulla http://purl.org/sig/ont/fma/fma61108
T202 23760-23765 Body_part denotes brain http://purl.org/sig/ont/fma/fma50801
T203 23844-23850 Body_part denotes cortex http://purl.org/sig/ont/fma/fma61109
T204 23852-23863 Body_part denotes hippocampus http://purl.org/sig/ont/fma/fma275020
T205 23873-23880 Body_part denotes putamen http://purl.org/sig/ont/fma/fma61834
T206 23882-23901 Body_part denotes hypoglossal nucleus http://purl.org/sig/ont/fma/fma54505
T207 23906-23926 Body_part denotes primary motor cortex http://purl.org/sig/ont/fma/fma224854
T208 24024-24031 Body_part denotes neurons http://purl.org/sig/ont/fma/fma54527
T209 24043-24053 Body_part denotes astrocytes http://purl.org/sig/ont/fma/fma54537
T210 24169-24175 Body_part denotes retina http://purl.org/sig/ont/fma/fma58301
T211 24230-24244 Body_part denotes photoreceptors http://purl.org/sig/ont/fma/fma85613
T212 24314-24330 Body_part denotes endocrine system http://purl.org/sig/ont/fma/fma9668
T213 24382-24402 Body_part denotes reproductive systems http://purl.org/sig/ont/fma/fma7160
T214 24413-24419 Body_part denotes testis http://purl.org/sig/ont/fma/fma7210
T215 24458-24471 Body_part denotes Sertoli cells http://purl.org/sig/ont/fma/fma72298
T216 24466-24471 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T217 24573-24580 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T218 24658-24664 Body_part denotes stroma http://purl.org/sig/ont/fma/fma81494
T219 24677-24692 Body_part denotes granulosa cells http://purl.org/sig/ont/fma/fma18718
T220 24687-24692 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T221 24847-24858 Body_part denotes osteoblasts http://purl.org/sig/ont/fma/fma66780
T222 24863-24874 Body_part denotes osteoclasts http://purl.org/sig/ont/fma/fma66781
T223 24890-24906 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T224 24901-24906 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T225 24911-24922 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877
T226 25038-25042 Body_part denotes skin http://purl.org/sig/ont/fma/fma7163
T227 25068-25101 Body_part denotes basal cell layer of the epidermis http://purl.org/sig/ont/fma/fma67540
T228 25068-25078 Body_part denotes basal cell http://purl.org/sig/ont/fma/fma62516
T229 25074-25078 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T230 25092-25101 Body_part denotes epidermis http://purl.org/sig/ont/fma/fma70596
T231 25119-25129 Body_part denotes basal cell http://purl.org/sig/ont/fma/fma62516
T232 25125-25129 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T233 25139-25153 Body_part denotes hair follicles http://purl.org/sig/ont/fma/fma70660
T234 25155-25174 Body_part denotes Smooth muscle cells http://purl.org/sig/ont/fma/fma14072
T235 25169-25174 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T236 25191-25207 Body_part denotes sebaceous glands http://purl.org/sig/ont/fma/fma71874
T237 25242-25253 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T238 25279-25294 Body_part denotes sebaceous gland http://purl.org/sig/ont/fma/fma59160
T239 25295-25300 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T240 25358-25363 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T241 25371-25385 Body_part denotes eccrine glands http://purl.org/sig/ont/fma/fma59154
T242 25379-25385 Body_part denotes glands http://purl.org/sig/ont/fma/fma71481
T243 25454-25463 Body_part denotes fat cells http://purl.org/sig/ont/fma/fma63880
T244 25458-25463 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T245 25508-25522 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T246 25603-25617 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T247 25603-25607 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T248 25766-25771 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T249 25776-25782 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T250 25833-25840 Body_part denotes tissues http://purl.org/sig/ont/fma/fma9637
T251 25850-25856 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T252 26399-26420 Body_part denotes left ventricular wall http://purl.org/sig/ont/fma/fma9556
T253 26616-26621 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T254 27558-27563 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T255 27574-27579 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T256 27632-27636 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T257 27673-27677 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T258 27705-27713 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T259 27822-27836 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T260 27878-27886 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T261 27914-27928 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T262 27972-27976 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T263 28199-28227 Body_part denotes vascular smooth muscle cells http://purl.org/sig/ont/fma/fma284560
T264 28222-28227 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T265 28449-28463 Body_part denotes left ventricle http://purl.org/sig/ont/fma/fma7101
T266 29286-29295 Body_part denotes G-protein http://purl.org/sig/ont/fma/fma61788
T267 29351-29365 Body_part denotes cardiomyocytes http://purl.org/sig/ont/fma/fma14067
T268 29370-29383 Body_part denotes blood vessels http://purl.org/sig/ont/fma/fma63183
T269 29370-29375 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T270 29806-29817 Body_part denotes neurotensin http://purl.org/sig/ont/fma/fma83371
T271 30012-30017 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T272 30700-30704 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T273 30754-30779 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T274 30774-30779 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T275 30819-30836 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T276 30831-30836 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T277 30876-30879 Body_part denotes arm http://purl.org/sig/ont/fma/fma24890
T278 30922-30926 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T279 31017-31021 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T280 31228-31232 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T281 31594-31598 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T282 31640-31645 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T283 31910-31914 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T284 32023-32033 Body_part denotes eosinophil http://purl.org/sig/ont/fma/fma62861
T285 32090-32102 Body_part denotes goblet cells http://purl.org/sig/ont/fma/fma13148
T286 32097-32102 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T287 32408-32416 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T288 32587-32591 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T289 32635-32639 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T290 32683-32688 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T291 32727-32731 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T292 32764-32772 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T293 32975-32979 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T294 33714-33717 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T295 33813-33819 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T296 33883-33895 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T297 33996-34001 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T298 34080-34084 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T299 34157-34163 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T300 34164-34168 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T301 34210-34222 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T302 35102-35106 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T303 35269-35276 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T304 35316-35324 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T305 35393-35401 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T306 35409-35417 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T307 35436-35441 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T308 35491-35497 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T309 35738-35750 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T310 35923-35930 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T311 36103-36107 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T312 36150-36157 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T313 36328-36332 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T314 36540-36547 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T315 36582-36589 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T316 36608-36618 Body_part denotes aminoacids http://purl.org/sig/ont/fma/fma82739
T317 36817-36835 Body_part denotes cellular membranes http://purl.org/sig/ont/fma/fma63841
T318 37226-37247 Body_part denotes contacts the receptor http://purl.org/sig/ont/fma/fma85595
T319 37418-37429 Body_part denotes cytoplasmic http://purl.org/sig/ont/fma/fma66835
T320 37515-37522 Body_part denotes glycine http://purl.org/sig/ont/fma/fma82753
T321 37530-37537 Body_part denotes alanine http://purl.org/sig/ont/fma/fma82749
T322 37569-37582 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T323 37569-37573 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T324 37947-37955 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T325 38072-38076 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T326 38158-38162 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T327 38351-38355 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T328 38618-38623 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T329 38733-38737 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T330 38982-38986 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T331 39156-39163 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T332 40424-40429 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T333 40587-40600 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T334 40587-40591 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T335 40685-40690 Body_part denotes helix http://purl.org/sig/ont/fma/fma60992
T336 40909-40923 Body_part denotes cell membranes http://purl.org/sig/ont/fma/fma63841
T337 40909-40913 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T338 41113-41117 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T339 41118-41127 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T340 41163-41169 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T341 41268-41275 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T342 41511-41515 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T343 41561-41565 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T344 41922-41929 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T345 42090-42103 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T346 42090-42094 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T347 42117-42132 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T348 42152-42161 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T349 42182-42199 Body_part denotes endocytic vesicle http://purl.org/sig/ont/fma/fma67463
T350 42256-42263 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T351 42383-42390 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T352 42585-42589 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T353 42733-42739 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T354 42817-42826 Body_part denotes aminoacid http://purl.org/sig/ont/fma/fma82739
T355 43039-43051 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T356 43211-43215 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T357 43511-43524 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T358 43511-43515 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T359 43549-43565 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T360 43560-43565 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T361 43575-43584 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T362 43749-43753 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T363 43949-43964 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T364 43971-43980 Body_part denotes endosomal http://purl.org/sig/ont/fma/fma67180
T365 44097-44102 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T366 44113-44118 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T367 44259-44263 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T368 44335-44339 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T369 44486-44489 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T370 44528-44534 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T371 44578-44582 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T372 44675-44690 Body_part denotes plasma membrane http://purl.org/sig/ont/fma/fma63841
T373 44782-44800 Body_part denotes endocytic vesicles http://purl.org/sig/ont/fma/fma67463
T374 44907-44911 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T375 45002-45006 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T376 45150-45157 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T377 45539-45551 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T378 45539-45543 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T379 45559-45564 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T380 45719-45727 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T381 45748-45753 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T382 47173-47180 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T383 47834-47839 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T384 48025-48032 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T385 48319-48332 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T386 48601-48608 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T387 48784-48789 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T388 48846-48853 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T389 50205-50212 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T390 50436-50443 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T391 50821-50826 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T392 50959-50964 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T393 51398-51403 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T394 52869-52876 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T395 53103-53107 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T396 53850-53855 Body_part denotes ridge http://purl.org/sig/ont/fma/fma75035
T397 55557-55563 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T398 55769-55774 Body_part denotes organ http://purl.org/sig/ont/fma/fma67498
T399 57808-57812 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T400 58495-58508 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T401 58495-58499 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T402 59967-59972 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T403 60060-60064 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T404 60140-60148 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T405 60574-60578 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T406 60901-60906 Body_part denotes lungs http://purl.org/sig/ont/fma/fma68877
T407 60939-60950 Body_part denotes neutrophils http://purl.org/sig/ont/fma/fma62860
T408 61778-61782 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T409 61971-61980 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T410 62057-62065 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T411 62207-62215 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T412 62392-62397 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T413 62407-62432 Body_part denotes alveolar epithelial cells http://purl.org/sig/ont/fma/fma62499
T414 62427-62432 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T415 62443-62448 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T416 62453-62466 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T417 62467-62472 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T418 62474-62485 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T419 62487-62496 Body_part denotes monocytes http://purl.org/sig/ont/fma/fma62864
T420 62658-62662 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T421 62786-62790 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T422 62947-62951 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T423 63163-63170 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T424 63210-63217 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T425 63237-63244 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T426 63285-63292 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T427 63413-63422 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T428 63436-63440 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T429 63649-63657 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T430 63758-63769 Body_part denotes macrophages http://purl.org/sig/ont/fma/fma63261
T431 63856-63865 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T432 63875-63879 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T433 63995-64000 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T434 64010-64014 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T435 64183-64193 Body_part denotes lymphocyte http://purl.org/sig/ont/fma/fma62863
T436 64978-64987 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T437 65318-65326 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T438 65429-65433 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T439 65674-65681 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T440 66127-66133 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T441 66134-66139 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T442 66493-66498 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T443 66731-66744 Body_part denotes immune system http://purl.org/sig/ont/fma/fma9825
T444 66821-66837 Body_part denotes epithelial cells http://purl.org/sig/ont/fma/fma66768
T445 66832-66837 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T446 66849-66853 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T447 66916-66920 Body_part denotes IL-1 http://purl.org/sig/ont/fma/fma86583
T448 68216-68224 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T449 68717-68721 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T450 68780-68784 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T451 69122-69129 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T452 69960-69964 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T453 69965-69969 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T454 70067-70074 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T455 70282-70286 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T456 70779-70783 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T457 70903-70907 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T458 71243-71250 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T459 71457-71464 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T460 71817-71829 Body_part denotes blood vessel http://purl.org/sig/ont/fma/fma63183
T461 71850-71856 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T462 72036-72040 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T463 72324-72328 Body_part denotes nose http://purl.org/sig/ont/fma/fma46472
T464 72691-72695 Body_part denotes axis http://purl.org/sig/ont/fma/fma12520
T465 72768-72775 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T466 72900-72906 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T467 72907-72914 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T468 72927-72938 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T469 72955-72962 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T470 73082-73093 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T471 73150-73160 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T472 73174-73179 Body_part denotes bowel http://purl.org/sig/ont/fma/fma7199
T473 73184-73187 Body_part denotes gut http://purl.org/sig/ont/fma/fma7199
T474 73302-73309 Body_part denotes glucose http://purl.org/sig/ont/fma/fma82743
T475 73330-73338 Body_part denotes pancreas http://purl.org/sig/ont/fma/fma7198
T476 73392-73399 Body_part denotes insulin http://purl.org/sig/ont/fma/fma83365
T477 73502-73516 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T478 73553-73558 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T479 73881-73885 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T480 73926-73932 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T481 74011-74016 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T482 74400-74404 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T483 74405-74409 Body_part denotes Lung http://purl.org/sig/ont/fma/fma7195
T484 74521-74531 Body_part denotes E-cadherin http://purl.org/sig/ont/fma/fma61792
T485 74575-74583 Body_part denotes vimentin http://purl.org/sig/ont/fma/fma67330
T486 74719-74723 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T487 75065-75069 Body_part denotes gene http://purl.org/sig/ont/fma/fma74402
T488 75255-75260 Body_part denotes colon http://purl.org/sig/ont/fma/fma14543
T489 75284-75290 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T490 75307-75311 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T491 75364-75370 Body_part denotes rectum http://purl.org/sig/ont/fma/fma14544
T492 75394-75401 Body_part denotes stomach http://purl.org/sig/ont/fma/fma7148
T493 75429-75433 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T494 75508-75512 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T495 75522-75526 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T496 75620-75624 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T497 75633-75640 Body_part denotes thyroid http://purl.org/sig/ont/fma/fma9603
T498 75663-75669 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T499 76516-76530 Body_part denotes uterine corpus http://purl.org/sig/ont/fma/fma17739
T500 76918-76923 Body_part denotes heart http://purl.org/sig/ont/fma/fma7088
T501 76925-76931 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T502 76991-76996 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T503 77222-77230 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T504 77320-77337 Body_part denotes respiratory tract http://purl.org/sig/ont/fma/fma265130
T505 77651-77663 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T506 77747-77754 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T507 77800-77812 Body_part denotes cell surface http://purl.org/sig/ont/fma/fma67653
T508 77800-77804 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-sample-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 19-29 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T2 19-23 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T3 282-294 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T4 812-845 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T5 847-851 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T6 889-898 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T7 889-893 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T8 919-943 Disease denotes COronaVIrus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T9 945-953 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T10 979-987 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T11 1075-1084 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T12 1075-1079 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T13 1131-1140 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T14 1131-1135 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T15 1407-1416 Disease denotes SARS-CoV2 http://purl.obolibrary.org/obo/MONDO_0100096
T16 1407-1411 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T17 1486-1498 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T18 1626-1636 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T19 1626-1630 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T20 1637-1646 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T21 1843-1852 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T22 2017-2025 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T23 2507-2515 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T24 2956-2978 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T25 3002-3014 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T26 3019-3043 Disease denotes congestive heart failure http://purl.obolibrary.org/obo/MONDO_0005009
T27 3636-3644 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 3636-3640 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T29 3771-3781 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T30 3771-3775 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T31 3823-3831 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T32 3953-3965 Disease denotes Hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T33 4011-4019 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T34 4085-4097 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T35 4290-4300 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T36 4290-4294 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T37 5306-5329 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T38 6490-6493 Disease denotes EST http://purl.obolibrary.org/obo/MONDO_0023726
T39 6626-6634 Disease denotes lymphoma http://purl.obolibrary.org/obo/MONDO_0005062
T40 7014-7027 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T41 7217-7250 Disease denotes idiopathic dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0016333
T42 8168-8207 Disease denotes hypertension and cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T43 11873-11881 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T44 11916-11926 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T45 11916-11920 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T46 11927-11936 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T47 11969-11977 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 14292-14296 Disease denotes ESCs http://purl.obolibrary.org/obo/MONDO_0009989
T49 14591-14595 Disease denotes ESCs http://purl.obolibrary.org/obo/MONDO_0009989
T50 14782-14794 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T51 14796-14804 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T52 14810-14842 Disease denotes chronic obstructive lung disease http://purl.obolibrary.org/obo/MONDO_0005002
T53 15557-15563 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T54 16171-16179 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T55 16227-16237 Disease denotes Sars-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T56 18056-18066 Disease denotes Sars-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T57 21626-21636 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T58 21626-21630 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T59 21645-21654 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T60 21710-21718 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T61 26611-26630 Disease denotes high blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T62 28481-28502 Disease denotes myocardial infarction http://purl.obolibrary.org/obo/MONDO_0005068
T63 28504-28506 Disease denotes MI http://purl.obolibrary.org/obo/MONDO_0005068
T64 28775-28797 Disease denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/MONDO_0005021
T65 30012-30025 Disease denotes heart failure http://purl.obolibrary.org/obo/MONDO_0005252
T66 30277-30289 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T67 30705-30711 Disease denotes Injury http://purl.obolibrary.org/obo/MONDO_0021178
T68 30922-30934 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T69 31011-31028 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T71 31030-31033 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T72 31036-31054 Disease denotes pulmonary fibrosis http://purl.obolibrary.org/obo/MONDO_0002771
T73 31056-31078 Disease denotes pulmonary hypertension http://purl.obolibrary.org/obo/MONDO_0005149
T74 31084-31119 Disease denotes acute respiratory distress syndrome http://purl.obolibrary.org/obo/MONDO_0006502
T75 31121-31125 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T76 31154-31158 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T77 31191-31194 Disease denotes ALI http://purl.obolibrary.org/obo/MONDO_0006502
T78 31233-31239 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T79 31293-31305 Disease denotes pancreatitis http://purl.obolibrary.org/obo/MONDO_0004982
T80 31307-31314 Disease denotes anthrax http://purl.obolibrary.org/obo/MONDO_0005119
T81 31319-31335 Disease denotes virus infections http://purl.obolibrary.org/obo/MONDO_0005108
T82 31345-31348 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T83 31355-31364 Disease denotes avian flu http://purl.obolibrary.org/obo/MONDO_0018695
T84 31369-31373 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T85 31442-31446 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T86 31539-31543 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T87 31627-31639 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T88 31915-31927 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T89 31999-32014 Disease denotes allergic asthma http://purl.obolibrary.org/obo/MONDO_0004784
T90 32063-32075 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T91 32259-32265 Disease denotes asthma http://purl.obolibrary.org/obo/MONDO_0004979
T92 32592-32604 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T93 33086-33090 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T94 33240-33255 Disease denotes avian influenza http://purl.obolibrary.org/obo/MONDO_0018695
T95 33395-33403 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T96 33466-33487 Disease denotes respiratory infective http://purl.obolibrary.org/obo/MONDO_0024355
T97 33506-33539 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T98 33541-33545 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T99 33770-33778 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T100 33770-33774 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T101 34112-34120 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T102 34112-34116 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T103 34312-34320 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T104 34312-34316 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T105 34332-34336 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T106 34376-34386 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T107 34581-34590 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T108 34658-34668 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T109 34658-34662 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T110 34702-34710 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T111 34702-34706 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T112 34758-34766 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T113 34768-34792 Disease denotes COronaVIrus Disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T114 34843-34853 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T115 34843-34847 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T116 35000-35008 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T117 35055-35065 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T118 35055-35059 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T119 35107-35116 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T120 35910-35920 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T121 35910-35914 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T122 36000-36008 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 36000-36004 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T124 36073-36083 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T125 36073-36077 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T126 36127-36135 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T127 36127-36131 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T128 36265-36273 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T129 36265-36269 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T130 36279-36289 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T131 36279-36283 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T132 36366-36374 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T133 36366-36370 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T134 36378-36388 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T135 36378-36382 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T136 36551-36559 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T137 36551-36555 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T138 36564-36574 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T139 36564-36568 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T140 37089-37097 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T141 37089-37093 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T142 37113-37123 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T143 37113-37117 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T144 37959-37967 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T145 37959-37963 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T146 37972-37982 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T147 37972-37976 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T148 38394-38404 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T149 38394-38398 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T150 38408-38416 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T151 38408-38412 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T152 38705-38715 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T153 38705-38709 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T154 38922-38930 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T155 38922-38926 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T156 38935-38945 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T157 38935-38939 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T158 39006-39014 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T159 39006-39010 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T160 39019-39029 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T161 39019-39023 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T162 42267-42277 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T163 42267-42271 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T164 42648-42658 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T165 42648-42652 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T166 42722-42732 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T167 42722-42726 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T168 42756-42764 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T169 42756-42760 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T170 43108-43118 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T171 43108-43112 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T172 43252-43260 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T173 43252-43256 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T174 43286-43296 Disease denotes SARS-COV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T175 43286-43290 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T176 43738-43748 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T177 43738-43742 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T178 43791-43799 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T179 44914-44924 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T180 44914-44918 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T181 44958-44968 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T182 44958-44962 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T183 44973-44981 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T184 44973-44977 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T185 45049-45059 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T186 45049-45053 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T187 45090-45098 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T188 45090-45094 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T189 45100-45108 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T190 45100-45104 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T191 45226-45236 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T192 45226-45230 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T193 45283-45291 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T194 45283-45287 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T195 45399-45409 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T196 45399-45403 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T197 45455-45465 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T198 45455-45459 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T199 45786-45796 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T200 45786-45790 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T201 45893-45903 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T202 45893-45897 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T203 46323-46333 Disease denotes SARS-COV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T204 46323-46327 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T205 46338-46346 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T206 46338-46342 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T207 46556-46566 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T208 46556-46560 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T209 46710-46720 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T210 46710-46714 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T211 46976-46986 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T212 46976-46980 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T213 47073-47083 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T214 47073-47077 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T215 47544-47554 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T216 47544-47548 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T217 47613-47621 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T218 47613-47617 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T219 47793-47803 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T220 47793-47797 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T221 47841-47851 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T222 47841-47845 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T223 47875-47883 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T224 47875-47879 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T225 48012-48022 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T226 48012-48016 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T227 48072-48076 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T228 48139-48149 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T229 48139-48143 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T230 48208-48216 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T231 48208-48212 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T232 48386-48396 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T233 48386-48390 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T234 48401-48409 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T235 48401-48405 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T236 48445-48455 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T237 48445-48449 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T238 48758-48768 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T239 48758-48762 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T240 48825-48835 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T241 48825-48829 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T242 48923-48927 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T243 48963-48967 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T244 49001-49005 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T245 49051-49055 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T246 49104-49108 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T247 49154-49158 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T248 49202-49206 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T249 49269-49273 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T250 49512-49520 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T251 49512-49516 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T252 49636-49644 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T253 49636-49640 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T254 49815-49825 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T255 49815-49819 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T256 49891-49901 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T257 49891-49895 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T258 50565-50573 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T259 50565-50569 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T260 50587-50597 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T261 50587-50591 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T262 50662-50672 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T263 50662-50666 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T264 50707-50717 Disease denotes S sequence http://purl.obolibrary.org/obo/MONDO_0007821
T265 50732-50740 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T266 50732-50736 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T267 51333-51343 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T268 51333-51337 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T269 51348-51356 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T270 51348-51352 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T271 51385-51393 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T272 51385-51389 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T273 51472-51482 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T274 51472-51476 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T275 51664-51674 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T276 51664-51668 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T277 51702-51706 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T278 52041-52051 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T279 52041-52045 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T280 52068-52072 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T281 52177-52187 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T282 52177-52181 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T283 52856-52866 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T284 52856-52860 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T285 52891-52899 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T286 52900-52909 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T287 53189-53193 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T288 53206-53216 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T289 53206-53210 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T290 53294-53302 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T291 53294-53298 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T292 53445-53455 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T293 53445-53449 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T294 53880-53890 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T295 53880-53884 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T296 54069-54077 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T297 54194-54231 Disease denotes hypertension, cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0001302
T298 54236-54260 Disease denotes type-2 diabetes mellitus http://purl.obolibrary.org/obo/MONDO_0005148
T299 54618-54630 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T300 54640-54648 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T301 54661-54684 Disease denotes cardiovascular diseases http://purl.obolibrary.org/obo/MONDO_0004995
T302 54834-54846 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T303 54856-54878 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T304 55046-55054 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T305 55268-55280 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T306 55382-55394 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T307 55402-55410 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T308 55422-55444 Disease denotes cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0004995
T309 55477-55485 Disease denotes Diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T310 55533-55537 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T311 55551-55570 Disease denotes acute kidney injury http://purl.obolibrary.org/obo/MONDO_0002492
T312 55825-55832 Disease denotes Obesity http://purl.obolibrary.org/obo/MONDO_0011122
T313 55888-55896 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T314 55915-55922 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122
T315 55983-55993 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T316 55983-55987 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T317 56313-56316 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T318 56598-56616 Disease denotes SARS-CoV infection http://purl.obolibrary.org/obo/MONDO_0005091
T319 56598-56602 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T320 56690-56700 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T321 56690-56694 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T322 56786-56796 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T323 56786-56790 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T324 56855-56858 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T325 57214-57218 Disease denotes Park http://purl.obolibrary.org/obo/MONDO_0008199
T326 57505-57508 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T327 57735-57747 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T328 57784-57793 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T329 57922-57937 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T330 58158-58194 Disease denotes hypertension, cardiovascular disease http://purl.obolibrary.org/obo/MONDO_0001302
T331 58199-58207 Disease denotes diabetes http://purl.obolibrary.org/obo/MONDO_0005015
T332 58281-58291 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T333 58281-58285 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T334 58525-58535 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T335 58525-58529 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T336 58536-58545 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T337 58706-58715 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T338 59195-59203 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T339 59208-59220 Disease denotes hypertension http://purl.obolibrary.org/obo/MONDO_0005044
T340 59242-59245 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T341 59575-59578 Disease denotes ARB http://purl.obolibrary.org/obo/MONDO_0012733
T342 59596-59604 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T343 59714-59722 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T344 59937-59947 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T345 59937-59941 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T346 59948-59957 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T347 60247-60255 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T348 60356-60366 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T349 60356-60360 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T350 60390-60393 Disease denotes flu http://purl.obolibrary.org/obo/MONDO_0005812
T351 60399-60415 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T352 60417-60424 Disease denotes COVID19 http://purl.obolibrary.org/obo/MONDO_0100096
T353 60552-60556 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T354 60579-60585 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T355 60688-60692 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T356 60758-60766 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T357 60772-60788 Disease denotes systemic disease http://purl.obolibrary.org/obo/MONDO_0015938
T358 60812-60821 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T359 61101-61107 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T360 61154-61163 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T361 61221-61229 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T362 61475-61484 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T363 61601-61609 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T364 61614-61623 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T365 61653-61657 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T366 62720-62732 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T367 63098-63102 Disease denotes PRRs http://purl.obolibrary.org/obo/MONDO_0025494
T368 63144-63147 Disease denotes NOD http://purl.obolibrary.org/obo/MONDO_0007435
T369 63246-63249 Disease denotes ASC http://purl.obolibrary.org/obo/MONDO_0019018
T370 63460-63472 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T371 63668-63678 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T372 63668-63672 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T373 63687-63697 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T374 63687-63691 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T375 63698-63707 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T376 63905-63913 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T377 64078-64089 Disease denotes lymphopenia http://purl.obolibrary.org/obo/MONDO_0003783
T378 64110-64118 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T379 64119-64128 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T380 64194-64200 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T381 64302-64312 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T382 64302-64306 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T383 65588-65600 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T384 66705-66720 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T385 67188-67203 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T386 67297-67307 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T387 67297-67301 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T388 67465-67475 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T389 67465-67469 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T390 67625-67642 Disease denotes hypovitaminosis D http://purl.obolibrary.org/obo/MONDO_0005520
T391 67668-67676 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T392 67853-67863 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T393 67853-67857 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T394 67896-67906 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T395 67896-67900 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T396 67988-68005 Disease denotes hypovitaminosis D http://purl.obolibrary.org/obo/MONDO_0005520
T397 68020-68030 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T398 68087-68109 Disease denotes respiratory infections http://purl.obolibrary.org/obo/MONDO_0024355
T399 68269-68279 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T400 68269-68273 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T401 68468-68476 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T402 68528-68538 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T403 68528-68532 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T404 68613-68622 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T405 68785-68791 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T406 68948-68957 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T407 69633-69641 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T408 69633-69637 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T409 69855-69863 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T410 69855-69859 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T411 70158-70162 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T412 70276-70293 Disease denotes acute lung injury http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796
T414 70297-70307 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T415 70313-70317 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T416 70708-70718 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T417 70708-70712 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T418 70908-70914 Disease denotes injury http://purl.obolibrary.org/obo/MONDO_0021178
T419 71089-71097 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T420 71395-71403 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T421 71658-71662 Disease denotes ARDS http://purl.obolibrary.org/obo/MONDO_0006502
T422 71775-71785 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T423 71775-71779 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T424 71786-71799 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T425 72005-72015 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T426 72005-72009 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T427 72112-72122 Disease denotes SARS-CoV-2 http://purl.obolibrary.org/obo/MONDO_0100096
T428 72112-72116 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T429 72597-72612 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108
T430 73040-73057 Disease denotes Hartnup’s disease http://purl.obolibrary.org/obo/MONDO_0009324
T431 73330-73338 Disease denotes pancreas http://purl.obolibrary.org/obo/MONDO_0021040
T432 73431-73438 Disease denotes Obesity http://purl.obolibrary.org/obo/MONDO_0011122
T433 73543-73567 Disease denotes increased blood pressure http://purl.obolibrary.org/obo/MONDO_0005044
T434 73649-73666 Disease denotes Alzheimer disease http://purl.obolibrary.org/obo/MONDO_0004975
T435 73721-73728 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T436 73840-73846 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T437 73874-73880 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T438 74011-74023 Disease denotes colon cancer http://purl.obolibrary.org/obo/MONDO_0021063
T439 74080-74104 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T440 74333-74338 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T441 74390-74416 Disease denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/MONDO_0005233
T442 74418-74423 Disease denotes NSCLC http://purl.obolibrary.org/obo/MONDO_0005233
T443 74647-74652 Disease denotes NSCLC http://purl.obolibrary.org/obo/MONDO_0005233
T444 74719-74730 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T445 74752-74760 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T446 74982-74988 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T447 74990-74994 Disease denotes Chai http://purl.obolibrary.org/obo/MONDO_0014493
T448 75086-75092 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T449 75247-75253 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T450 75255-75275 Disease denotes colon adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002271
T451 75277-75281 Disease denotes COAD http://purl.obolibrary.org/obo/MONDO_0002271
T452 75312-75321 Disease denotes carcinoma http://purl.obolibrary.org/obo/MONDO_0004993
T453 75330-75355 Disease denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0006047
T454 75357-75361 Disease denotes PAAD http://purl.obolibrary.org/obo/MONDO_0006047
T455 75364-75385 Disease denotes rectum adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0002169
T456 75387-75391 Disease denotes READ http://purl.obolibrary.org/obo/MONDO_0002169
T457 75394-75416 Disease denotes stomach adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005036
T458 75418-75422 Disease denotes STAD http://purl.obolibrary.org/obo/MONDO_0005036
T459 75429-75448 Disease denotes lung adenocarcinoma http://purl.obolibrary.org/obo/MONDO_0005061
T460 75450-75454 Disease denotes LUAD http://purl.obolibrary.org/obo/MONDO_0005061
T461 75508-75536 Disease denotes lung squamous cell carcinoma http://purl.obolibrary.org/obo/MONDO_0005097
T462 75538-75542 Disease denotes LUSC http://purl.obolibrary.org/obo/MONDO_0005097
T463 75596-75602 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T464 75626-75630 Disease denotes TGCT http://purl.obolibrary.org/obo/MONDO_0006906|http://purl.obolibrary.org/obo/MONDO_0010108
T466 75633-75650 Disease denotes thyroid carcinoma http://purl.obolibrary.org/obo/MONDO_0015075
T467 75652-75656 Disease denotes THCA http://purl.obolibrary.org/obo/MONDO_0015075
T468 75663-75681 Disease denotes kidney chromophobe http://purl.obolibrary.org/obo/MONDO_0017885
T469 75683-75687 Disease denotes KICH http://purl.obolibrary.org/obo/MONDO_0017885
T470 76411-76416 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T471 76516-76552 Disease denotes uterine corpus endometrial carcinoma http://purl.obolibrary.org/obo/MONDO_0000553
T472 76554-76558 Disease denotes UCEC http://purl.obolibrary.org/obo/MONDO_0000553
T473 77350-77358 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T474 77457-77461 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T475 77470-77479 Disease denotes SARS-Cov2 http://purl.obolibrary.org/obo/MONDO_0100096
T476 77470-77474 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T477 77907-77915 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T478 78152-78160 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-sample-PD-MAT

Id Subject Object Predicate Lexical cue
T1 277-281 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T2 621-642 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T3 644-650 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T4 656-665 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestine
T5 2993-3001 http://purl.obolibrary.org/obo/MAT_0000034 denotes arterial
T6 3030-3035 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T7 4208-4212 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand
T8 5996-6001 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T9 5996-6001 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T10 7014-7019 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T11 7160-7175 http://purl.obolibrary.org/obo/MAT_0000497 denotes heart ventricle
T12 7160-7165 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T13 7478-7483 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T14 7495-7501 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T15 9802-9807 http://purl.obolibrary.org/obo/MAT_0000239 denotes stems
T16 10896-10900 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T17 11651-11657 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T18 11768-11772 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T19 11804-11808 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T20 11864-11869 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T21 14830-14834 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T22 14878-14882 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T23 15324-15328 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T24 15409-15413 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T25 15764-15768 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T26 16649-16654 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T27 18562-18583 http://purl.obolibrary.org/obo/MAT_0000016 denotes cardiovascular system
T28 18588-18594 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T29 18797-18808 http://purl.obolibrary.org/obo/MAT_0000393 denotes vasculature
T30 18830-18838 http://purl.obolibrary.org/obo/MAT_0000034 denotes arteries
T31 18843-18848 http://purl.obolibrary.org/obo/MAT_0000037 denotes veins
T32 18860-18873 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T33 18867-18873 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T34 18979-18986 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T35 19090-19097 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T36 19172-19176 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T37 19251-19257 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T38 19271-19279 http://purl.obolibrary.org/obo/MAT_0000034 denotes arteries
T39 19317-19330 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T40 19324-19330 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T41 19344-19349 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T42 19449-19455 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T43 19508-19513 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T44 19621-19637 http://purl.obolibrary.org/obo/MAT_0000197 denotes lymphatic system
T45 19679-19685 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T46 19687-19698 http://purl.obolibrary.org/obo/MAT_0000197 denotes lymph nodes
T47 19687-19698 http://purl.obolibrary.org/obo/MAT_0000442 denotes lymph nodes
T48 19687-19692 http://purl.obolibrary.org/obo/MAT_0000055 denotes lymph
T49 19704-19715 http://purl.obolibrary.org/obo/MAT_0000084 denotes bone marrow
T50 19704-19708 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T51 19761-19772 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood cells
T52 19761-19766 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T53 19961-19966 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T54 20032-20038 http://purl.obolibrary.org/obo/MAT_0000496 denotes atrium
T55 20042-20051 http://purl.obolibrary.org/obo/MAT_0000497 denotes ventricle
T56 20259-20264 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T57 20532-20538 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T58 20787-20795 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T59 21211-21217 http://purl.obolibrary.org/obo/MAT_0000187 denotes larynx
T60 21219-21226 http://purl.obolibrary.org/obo/MAT_0000137 denotes trachea
T61 21240-21244 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T62 21824-21830 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T63 21848-21862 http://purl.obolibrary.org/obo/MAT_0000079 denotes salivary gland
T64 21857-21862 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland
T65 21887-21891 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T66 22309-22314 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T67 22409-22414 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T68 22453-22459 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessel
T69 22729-22744 http://purl.obolibrary.org/obo/MAT_0000047 denotes small intestine
T70 22735-22744 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestine
T71 22760-22768 http://purl.obolibrary.org/obo/MAT_0000044 denotes duodenum
T72 22770-22777 http://purl.obolibrary.org/obo/MAT_0000045 denotes jejunum
T73 22783-22788 http://purl.obolibrary.org/obo/MAT_0000282 denotes ileum
T74 22820-22825 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T75 22876-22883 http://purl.obolibrary.org/obo/MAT_0000051 denotes stomach
T76 22888-22893 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T77 23142-23162 http://purl.obolibrary.org/obo/MAT_0000076 denotes islets of Langerhans
T78 23249-23254 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T79 23265-23278 http://purl.obolibrary.org/obo/MAT_0000421 denotes telencephalon
T80 23325-23330 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T81 23591-23597 http://purl.obolibrary.org/obo/MAT_0000487 denotes dorsal
T82 23760-23765 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain
T83 23852-23863 http://purl.obolibrary.org/obo/MAT_0000114 denotes hippocampus
T84 24169-24175 http://purl.obolibrary.org/obo/MAT_0000142 denotes retina
T85 24314-24330 http://purl.obolibrary.org/obo/MAT_0000021 denotes endocrine system
T86 24366-24370 http://purl.obolibrary.org/obo/MAT_0000029 denotes male
T87 24375-24402 http://purl.obolibrary.org/obo/MAT_0000028 denotes female reproductive systems
T88 24413-24419 http://purl.obolibrary.org/obo/MAT_0000132 denotes testis
T89 24820-24824 http://purl.obolibrary.org/obo/MAT_0000299 denotes bone
T90 25038-25042 http://purl.obolibrary.org/obo/MAT_0000284 denotes skin
T91 25092-25101 http://purl.obolibrary.org/obo/MAT_0000154 denotes epidermis
T92 25139-25143 http://purl.obolibrary.org/obo/MAT_0000160 denotes hair
T93 25155-25168 http://purl.obolibrary.org/obo/MAT_0000303 denotes Smooth muscle
T94 25162-25168 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T95 25201-25207 http://purl.obolibrary.org/obo/MAT_0000021 denotes glands
T96 25289-25294 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland
T97 25379-25385 http://purl.obolibrary.org/obo/MAT_0000021 denotes glands
T98 25508-25522 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue
T99 25766-25771 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T100 25776-25782 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T101 26616-26621 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T102 26616-26621 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T103 27558-27563 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T104 27565-27572 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T105 27574-27579 http://purl.obolibrary.org/obo/MAT_0000135 denotes lungs
T106 28208-28221 http://purl.obolibrary.org/obo/MAT_0000303 denotes smooth muscle
T107 28215-28221 http://purl.obolibrary.org/obo/MAT_0000025 denotes muscle
T108 28454-28463 http://purl.obolibrary.org/obo/MAT_0000497 denotes ventricle
T109 28731-28737 http://purl.obolibrary.org/obo/MAT_0000036 denotes hearts
T110 29370-29383 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessels
T111 29370-29375 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T112 29370-29375 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T113 30012-30017 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T114 30700-30704 http://purl.obolibrary.org/obo/MAT_0000135 denotes Lung
T115 30803-30810 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessels
T116 30922-30926 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T117 31017-31021 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T118 31228-31232 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T119 31573-31579 http://purl.obolibrary.org/obo/MAT_0000393 denotes vessel
T120 31594-31598 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T121 31910-31914 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T122 32587-32591 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T123 32683-32688 http://purl.obolibrary.org/obo/MAT_0000135 denotes lungs
T124 34157-34163 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T125 39288-39293 http://purl.obolibrary.org/obo/MAT_0000294 denotes heads
T126 49463-49467 http://purl.obolibrary.org/obo/MAT_0000158 denotes claw
T127 51570-51578 http://purl.obolibrary.org/obo/MAT_0000491 denotes proximal
T128 54127-54132 http://purl.obolibrary.org/obo/MAT_0000029 denotes males
T129 55557-55563 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T130 57808-57812 http://purl.obolibrary.org/obo/MAT_0000091 denotes hand
T131 60574-60578 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T132 60901-60906 http://purl.obolibrary.org/obo/MAT_0000135 denotes lungs
T133 66127-66133 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T134 68780-68784 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T135 70282-70286 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T136 70903-70907 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T137 71817-71829 http://purl.obolibrary.org/obo/MAT_0000393 denotes blood vessel
T138 71817-71822 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T139 71817-71822 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T140 71850-71856 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T141 72324-72328 http://purl.obolibrary.org/obo/MAT_0000139 denotes nose
T142 72900-72906 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T143 73184-73187 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut
T144 73330-73338 http://purl.obolibrary.org/obo/MAT_0000075 denotes pancreas
T145 73502-73516 http://purl.obolibrary.org/obo/MAT_0000015 denotes adipose tissue
T146 73553-73558 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T147 73553-73558 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T148 74011-74016 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T149 74405-74409 http://purl.obolibrary.org/obo/MAT_0000135 denotes Lung
T150 74719-74723 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T151 75255-75260 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon
T152 75284-75290 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T153 75364-75370 http://purl.obolibrary.org/obo/MAT_0000050 denotes rectum
T154 75394-75401 http://purl.obolibrary.org/obo/MAT_0000051 denotes stomach
T155 75429-75433 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T156 75508-75512 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T157 75615-75624 http://purl.obolibrary.org/obo/MAT_0000334 denotes germ cell
T158 75633-75640 http://purl.obolibrary.org/obo/MAT_0000081 denotes thyroid
T159 75663-75669 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T160 76918-76923 http://purl.obolibrary.org/obo/MAT_0000036 denotes heart
T161 76925-76931 http://purl.obolibrary.org/obo/MAT_0000119 denotes kidney
T162 76991-76996 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T163 76991-76996 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood

LitCovid-sample-PD-GO-BP-0

Id Subject Object Predicate Lexical cue
T1 282-294 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2 327-342 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T3 352-367 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T4 459-474 http://purl.obolibrary.org/obo/GO_0006412 denotes translationally
T5 478-491 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 493-508 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7 2657-2667 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T8 3899-3909 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9 5240-5251 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T10 6028-6039 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T11 6888-6901 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T12 10512-10525 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T13 10685-10700 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcriptional
T14 10707-10722 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T15 10733-10746 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T16 10747-10757 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T17 10920-10945 http://purl.obolibrary.org/obo/GO_0009048 denotes X chromosome inactivation
T18 12059-12072 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T19 12760-12770 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T20 12965-12978 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T21 13113-13123 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22 13206-13225 http://purl.obolibrary.org/obo/GO_0016571 denotes histone methylation
T23 13214-13225 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T24 13273-13286 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T25 13328-13341 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T26 13518-13531 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T27 13625-13640 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T28 14043-14056 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T29 14633-14644 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T30 14679-14689 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T31 14857-14870 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T32 14905-14924 http://purl.obolibrary.org/obo/GO_0016571 denotes Histone methylation
T33 14913-14924 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T34 14967-14977 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T35 15069-15082 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T36 15253-15264 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T37 15392-15405 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T38 15515-15528 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T39 15542-15553 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T40 16202-16223 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T41 16312-16341 http://purl.obolibrary.org/obo/GO_0003712 denotes transcriptional co-regulation
T42 16331-16341 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T43 16494-16513 http://purl.obolibrary.org/obo/GO_0006338 denotes chromatin remodeler
T44 16528-16541 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T45 16664-16674 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T46 16915-16926 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T47 16942-16953 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T48 16957-16973 http://purl.obolibrary.org/obo/GO_0009299 denotes mRNA transcripts
T49 16993-17025 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modifications
T50 17029-17042 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T51 17047-17062 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T52 17082-17097 http://purl.obolibrary.org/obo/GO_0006412 denotes translationally
T53 17195-17206 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T54 18031-18052 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T55 18098-18113 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T56 18120-18135 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T57 18146-18159 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T58 18160-18170 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T59 18199-18209 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T60 18222-18235 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T61 18237-18248 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T62 18259-18272 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T63 18655-18678 http://purl.obolibrary.org/obo/GO_0050801 denotes electrolyte homeostasis
T64 18667-18678 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T65 23353-23363 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T66 26059-26069 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T67 26143-26159 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstrictive
T68 26729-26754 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T69 27259-27278 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T70 27259-27269 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T71 27298-27323 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T72 27864-27873 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T73 27878-27897 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T74 27972-27983 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T75 27977-27983 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T76 28228-28248 http://purl.obolibrary.org/obo/GO_1990874 denotes (VSMC) proliferation
T77 28936-28961 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T78 29667-29684 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T79 29667-29676 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T80 31627-31639 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T81 31915-31927 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T82 32063-32075 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T83 32103-32113 http://purl.obolibrary.org/obo/GO_0036074 denotes metaplasia
T84 32471-32477 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T85 32505-32523 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T86 32505-32514 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T87 32592-32604 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T88 34813-34825 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T89 37878-37893 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T90 38817-38832 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T91 39135-39146 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T92 39539-39553 http://purl.obolibrary.org/obo/GO_0020012 denotes immune evasion
T93 39539-39553 http://purl.obolibrary.org/obo/GO_0051805 denotes immune evasion
T94 41027-41041 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T95 41032-41041 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T96 41488-41497 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T97 42063-42077 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T98 42068-42077 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T99 42675-42682 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T100 43754-43761 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T101 43903-43918 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T102 44448-44463 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T103 44741-44752 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T104 52640-52647 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T105 57922-57937 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T106 60184-60204 http://purl.obolibrary.org/obo/GO_0055085 denotes membrane transporter
T107 60331-60352 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T108 60399-60415 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T109 61119-61124 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T110 61799-61802 http://purl.obolibrary.org/obo/GO_0004298 denotes MCP
T111 62359-62376 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T112 62359-62376 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T113 62546-62567 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T114 62584-62593 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T115 62584-62593 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T116 62632-62641 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T117 62632-62641 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T118 62658-62668 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T119 62663-62668 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T120 62678-62695 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T121 62678-62695 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T122 62720-62732 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T123 62775-62796 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T124 62786-62796 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T125 62791-62796 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T126 63218-63236 http://purl.obolibrary.org/obo/GO_0006919 denotes caspase activating
T127 63253-63262 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T128 63253-63262 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T129 63441-63446 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T130 63460-63472 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T131 63777-63786 http://purl.obolibrary.org/obo/GO_0039707 denotes viroporin
T132 64828-64834 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T133 64851-64855 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T134 64913-64926 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T135 65076-65081 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T136 65145-65154 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T137 65457-65478 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T138 65588-65600 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T139 65832-65853 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T140 66537-66564 http://purl.obolibrary.org/obo/GO_0008191 denotes metalloproteinase inhibitor
T141 66705-66720 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T142 67100-67121 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T143 67188-67203 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T144 68743-68760 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T145 68743-68760 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T146 69130-69155 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T147 69960-69976 http://purl.obolibrary.org/obo/GO_0000768 denotes cell-cell fusion
T148 69960-69976 http://purl.obolibrary.org/obo/GO_0045026 denotes cell-cell fusion
T149 69965-69976 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T150 70135-70153 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T151 70755-70783 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry in the host cell
T152 72338-72345 http://purl.obolibrary.org/obo/GO_0071626 denotes chewing
T153 72400-72412 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T154 72443-72462 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T155 72597-72612 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T156 72955-72972 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T157 72963-72972 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T158 73082-73105 http://purl.obolibrary.org/obo/GO_0080144 denotes amino acids homeostasis
T159 73094-73105 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T160 73150-73170 http://purl.obolibrary.org/obo/GO_0006865 denotes amino acid transport
T161 73161-73170 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T162 73260-73284 http://purl.obolibrary.org/obo/GO_0019222 denotes regulation of metabolism
T163 73260-73270 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T164 73274-73284 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T165 73310-73321 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T166 73392-73409 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T167 73400-73409 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T168 73881-73892 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T169 73886-73892 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T170 73910-73922 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T171 74339-74345 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T172 74374-74386 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T173 74610-74643 http://purl.obolibrary.org/obo/GO_0001837 denotes epithelial-mesenchymal transition
T174 75210-75223 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T175 75477-75490 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T176 75555-75568 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T177 75711-75724 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T178 75882-75895 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T179 75921-75932 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T180 75980-75991 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T181 76047-76058 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T182 76212-76223 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T183 76571-76584 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T184 76977-77005 http://purl.obolibrary.org/obo/GO_0008217 denotes regulation of blood pressure
T185 76977-76987 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T186 77025-77036 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T187 77222-77241 http://purl.obolibrary.org/obo/GO_0042107 denotes cytokine metabolism
T188 77231-77241 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism

LitCovid-sample-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1486-1498 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T2 1966-1980 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T3 2956-2978 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T4 3002-3014 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 3019-3043 Phenotype denotes congestive heart failure http://purl.obolibrary.org/obo/HP_0001635
T6 3953-3965 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 4085-4097 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 5306-5329 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T9 6626-6634 Phenotype denotes lymphoma http://purl.obolibrary.org/obo/HP_0002665
T10 7014-7027 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T11 7228-7250 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T12 8168-8180 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 8185-8207 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T14 14782-14794 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T15 14818-14842 Phenotype denotes obstructive lung disease http://purl.obolibrary.org/obo/HP_0006536
T16 26611-26630 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T17 27705-27719 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T18 28481-28502 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T19 28504-28506 Phenotype denotes MI http://purl.obolibrary.org/obo/HP_0001658
T20 28775-28797 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T21 29498-29504 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T22 30012-30025 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T30 31293-31305 Phenotype denotes pancreatitis http://purl.obolibrary.org/obo/HP_0001733
T31 31463-31473 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T32 31514-31520 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T33 31599-31605 Phenotype denotes oedema http://purl.obolibrary.org/obo/HP_0000969
T34 32008-32014 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T23 30277-30289 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T24 30922-30934 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T25 31036-31054 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T26 31066-31078 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T27 31090-31110 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T28 31268-31274 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T29 31281-31291 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T35 32259-32265 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T36 32408-32422 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T37 32764-32778 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T38 33466-33487 Phenotype denotes respiratory infective http://purl.obolibrary.org/obo/HP_0011947
T39 34539-34544 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T40 34553-34575 Phenotype denotes respiratory impairment http://purl.obolibrary.org/obo/HP_0002093
T41 34581-34590 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T42 54194-54206 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T43 54208-54231 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T44 54243-54260 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T45 54618-54630 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T46 54661-54684 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T47 54834-54846 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T48 54856-54878 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T49 55268-55280 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T50 55382-55394 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T51 55422-55444 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T52 55551-55570 Phenotype denotes acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T53 55591-55596 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T54 55825-55832 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T55 55915-55922 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T56 57735-57747 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T57 58158-58170 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T58 58172-58194 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T59 58814-58834 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T60 59208-59220 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T61 60812-60821 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T62 61112-61124 Phenotype denotes sudden death http://purl.obolibrary.org/obo/HP_0001699
T63 61614-61623 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T64 62057-62071 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T65 62207-62221 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T66 63649-63663 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T67 64078-64089 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T68 64119-64128 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T69 65318-65332 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T70 67491-67511 Phenotype denotes vitamin D deficiency http://purl.obolibrary.org/obo/HP_0100512
T71 68010-68030 Phenotype denotes pulmonary infections http://purl.obolibrary.org/obo/HP_0006532
T72 68087-68109 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T73 68216-68230 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T74 73431-73438 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T75 73543-73567 Phenotype denotes increased blood pressure http://purl.obolibrary.org/obo/HP_0032263
T76 73649-73666 Phenotype denotes Alzheimer disease http://purl.obolibrary.org/obo/HP_0002511
T77 73840-73846 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T78 73874-73880 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T79 74011-74023 Phenotype denotes colon cancer http://purl.obolibrary.org/obo/HP_0003003
T80 74080-74104 Phenotype denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/HP_0001402
T81 74333-74338 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T82 74390-74416 Phenotype denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/HP_0030358
T83 74719-74730 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T84 74982-74988 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T85 75086-75092 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T86 75312-75321 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T87 75330-75355 Phenotype denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/HP_0006725
T88 75429-75448 Phenotype denotes lung adenocarcinoma http://purl.obolibrary.org/obo/HP_0030078
T89 75513-75536 Phenotype denotes squamous cell carcinoma http://purl.obolibrary.org/obo/HP_0002860
T90 75633-75650 Phenotype denotes thyroid carcinoma http://purl.obolibrary.org/obo/HP_0002890
T91 75652-75656 Phenotype denotes THCA http://purl.obolibrary.org/obo/HP_0002890
T92 76411-76416 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T93 76531-76552 Phenotype denotes endometrial carcinoma http://purl.obolibrary.org/obo/HP_0012114

LitCovid-sample-GO-BP

Id Subject Object Predicate Lexical cue
T1 282-294 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T2 327-342 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T3 352-367 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T4 459-474 http://purl.obolibrary.org/obo/GO_0006412 denotes translationally
T5 478-491 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T6 493-508 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T7 2657-2667 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T8 3899-3909 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T9 5240-5251 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T10 6028-6039 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T11 6888-6901 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T12 10512-10525 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T13 10685-10700 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcriptional
T14 10707-10722 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T15 10733-10746 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T16 10747-10757 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T17 10920-10945 http://purl.obolibrary.org/obo/GO_0009048 denotes X chromosome inactivation
T18 12059-12072 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T19 12760-12770 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T20 12965-12978 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T21 13113-13123 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22 13206-13225 http://purl.obolibrary.org/obo/GO_0016571 denotes histone methylation
T23 13214-13225 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T24 13273-13286 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T25 13328-13341 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T26 13518-13531 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T27 13625-13640 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T28 14043-14056 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T29 14633-14644 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T30 14679-14689 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T31 14857-14870 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T32 14905-14924 http://purl.obolibrary.org/obo/GO_0016571 denotes Histone methylation
T33 14913-14924 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T34 14967-14977 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T35 15069-15082 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T36 15249-15264 http://purl.obolibrary.org/obo/GO_0006306 denotes DNA methylation
T37 15253-15264 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T38 15392-15405 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T39 15515-15528 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T40 15542-15553 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T41 16202-16223 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T42 16312-16341 http://purl.obolibrary.org/obo/GO_0003712 denotes transcriptional co-regulation
T43 16331-16341 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T44 16494-16513 http://purl.obolibrary.org/obo/GO_0006338 denotes chromatin remodeler
T45 16528-16548 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T46 16528-16541 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T47 16664-16674 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T48 16915-16926 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T49 16942-16953 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T50 16957-16973 http://purl.obolibrary.org/obo/GO_0009299 denotes mRNA transcripts
T51 16993-17025 http://purl.obolibrary.org/obo/GO_0043687 denotes post-translational modifications
T52 17029-17042 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T53 17047-17062 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T54 17082-17097 http://purl.obolibrary.org/obo/GO_0006412 denotes translationally
T55 17195-17206 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T56 18031-18052 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T57 18098-18113 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T58 18120-18135 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T59 18146-18159 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T60 18160-18170 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T61 18199-18209 http://purl.obolibrary.org/obo/GO_0065007 denotes Regulation
T62 18222-18235 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T63 18237-18248 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T64 18259-18272 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T65 18655-18678 http://purl.obolibrary.org/obo/GO_0050801 denotes electrolyte homeostasis
T66 18667-18678 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T67 23353-23363 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T68 26059-26069 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T69 26143-26159 http://purl.obolibrary.org/obo/GO_0042310 denotes vasoconstrictive
T70 26729-26754 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T71 27259-27278 http://purl.obolibrary.org/obo/GO_0007165 denotes signalling pathways
T72 27259-27269 http://purl.obolibrary.org/obo/GO_0023052 denotes signalling
T73 27298-27323 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T74 27864-27873 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T75 27878-27897 http://purl.obolibrary.org/obo/GO_0001816 denotes cytokine production
T76 27972-27983 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T77 27977-27983 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T78 28150-28162 http://purl.obolibrary.org/obo/GO_0042311 denotes vasodilation
T79 28228-28248 http://purl.obolibrary.org/obo/GO_1990874 denotes (VSMC) proliferation
T80 28936-28961 http://purl.obolibrary.org/obo/GO_0004180 denotes carboxypeptidase activity
T81 29667-29684 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T82 29667-29676 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T83 31627-31639 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T84 31915-31927 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T85 32063-32075 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T86 32103-32113 http://purl.obolibrary.org/obo/GO_0036074 denotes metaplasia
T87 32471-32477 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T88 32505-32523 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T89 32505-32514 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T90 32592-32604 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T91 34813-34825 http://purl.obolibrary.org/obo/GO_0000003 denotes reproduction
T92 37878-37893 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T93 38817-38832 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T94 39135-39146 http://purl.obolibrary.org/obo/GO_0006508 denotes proteolysis
T95 39539-39553 http://purl.obolibrary.org/obo/GO_0042783 denotes immune evasion
T96 41027-41041 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T97 41032-41041 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T98 41488-41497 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T99 42063-42077 http://purl.obolibrary.org/obo/GO_0046931 denotes pore formation
T100 42068-42077 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T101 42675-42682 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T102 43754-43761 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T103 43903-43918 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T104 44448-44463 http://purl.obolibrary.org/obo/GO_0061025 denotes membrane fusion
T105 44741-44752 http://purl.obolibrary.org/obo/GO_0006897 denotes endocytosis
T106 52640-52647 http://purl.obolibrary.org/obo/GO_0009606 denotes tropism
T107 57922-57937 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T108 60184-60204 http://purl.obolibrary.org/obo/GO_0055085 denotes membrane transporter
T109 60331-60352 http://purl.obolibrary.org/obo/GO_0006954 denotes Inflammatory Response
T110 60399-60415 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T111 62359-62376 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T112 62359-62376 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T113 62546-62567 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T114 62584-62593 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T115 62584-62593 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T116 62598-62608 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T117 62632-62641 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T118 62632-62641 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T119 62658-62668 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T120 62678-62695 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T121 62678-62695 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T122 62720-62732 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T123 62743-62753 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T124 62775-62796 http://purl.obolibrary.org/obo/GO_0012501 denotes programmed cell death
T125 62786-62796 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T126 62895-62905 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T127 63218-63236 http://purl.obolibrary.org/obo/GO_0006919 denotes caspase activating
T128 63253-63262 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T129 63253-63262 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T130 63441-63446 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T131 63460-63472 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T132 63709-63719 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T133 63777-63786 http://purl.obolibrary.org/obo/GO_0039707 denotes viroporin
T134 63928-63938 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T135 64204-64214 http://purl.obolibrary.org/obo/GO_0070269 denotes pyroptosis
T136 64828-64834 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T137 64851-64855 http://purl.obolibrary.org/obo/GO_0005006 denotes EGFR
T138 64913-64933 http://purl.obolibrary.org/obo/GO_0000981 denotes transcription factor
T139 64913-64926 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T140 65076-65081 http://purl.obolibrary.org/obo/GO_0004915 denotes IL-6R
T141 65145-65154 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T142 65457-65478 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T143 65588-65600 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T144 65832-65853 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T145 66537-66564 http://purl.obolibrary.org/obo/GO_0008191 denotes metalloproteinase inhibitor
T146 66705-66720 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T147 67100-67121 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T148 67188-67203 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T149 68743-68760 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T150 68743-68760 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T151 69130-69155 http://purl.obolibrary.org/obo/GO_0051701 denotes interaction with the host
T152 69960-69976 http://purl.obolibrary.org/obo/GO_0140253 denotes cell-cell fusion
T153 69960-69976 http://purl.obolibrary.org/obo/GO_0045026 denotes cell-cell fusion
T154 69965-69976 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T155 69965-69976 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T156 70755-70783 http://purl.obolibrary.org/obo/GO_0046718 denotes viral entry in the host cell
T157 72338-72345 http://purl.obolibrary.org/obo/GO_0071626 denotes chewing
T158 72400-72412 http://purl.obolibrary.org/obo/GO_0051235 denotes sequestering
T159 72443-72462 http://purl.obolibrary.org/obo/GO_0044409 denotes entry into the host
T160 72597-72612 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T161 72955-72972 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T162 72963-72972 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T163 73082-73105 http://purl.obolibrary.org/obo/GO_0080144 denotes amino acids homeostasis
T164 73094-73105 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T165 73150-73170 http://purl.obolibrary.org/obo/GO_0006865 denotes amino acid transport
T166 73161-73170 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T167 73260-73284 http://purl.obolibrary.org/obo/GO_0019222 denotes regulation of metabolism
T168 73260-73270 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T169 73274-73284 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T170 73302-73321 http://purl.obolibrary.org/obo/GO_0042593 denotes glucose homeostasis
T171 73310-73321 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T172 73392-73409 http://purl.obolibrary.org/obo/GO_0030073 denotes insulin secretion
T173 73400-73409 http://purl.obolibrary.org/obo/GO_0046903 denotes secretion
T174 73881-73892 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T175 73886-73892 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T176 73910-73922 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T177 74339-74345 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T178 74374-74386 http://purl.obolibrary.org/obo/GO_0001525 denotes angiogenesis
T179 74610-74643 http://purl.obolibrary.org/obo/GO_0001837 denotes epithelial-mesenchymal transition
T180 75210-75223 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T181 75477-75490 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T182 75555-75568 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T183 75711-75724 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T184 75882-75895 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T185 75921-75932 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T186 75980-75991 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T187 76047-76058 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T188 76212-76223 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T189 76571-76584 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T190 76977-77005 http://purl.obolibrary.org/obo/GO_0008217 denotes regulation of blood pressure
T191 76977-76987 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T192 77025-77036 http://purl.obolibrary.org/obo/GO_0042592 denotes homeostasis
T193 77231-77241 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1486-1498 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T2 1966-1980 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T3 2956-2978 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T4 3002-3014 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T5 3019-3043 Phenotype denotes congestive heart failure http://purl.obolibrary.org/obo/HP_0001635
T6 3953-3965 Phenotype denotes Hypertension http://purl.obolibrary.org/obo/HP_0000822
T7 4085-4097 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T8 5306-5329 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T9 6626-6634 Phenotype denotes lymphoma http://purl.obolibrary.org/obo/HP_0002665
T10 7014-7027 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T11 7228-7250 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T12 8168-8180 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T13 8185-8207 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T14 14782-14794 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T15 14818-14842 Phenotype denotes obstructive lung disease http://purl.obolibrary.org/obo/HP_0006536
T16 26611-26630 Phenotype denotes high blood pressure http://purl.obolibrary.org/obo/HP_0000822
T17 27705-27719 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T18 28481-28502 Phenotype denotes myocardial infarction http://purl.obolibrary.org/obo/HP_0001658
T19 28504-28506 Phenotype denotes MI http://purl.obolibrary.org/obo/HP_0001658
T20 28775-28797 Phenotype denotes dilated cardiomyopathy http://purl.obolibrary.org/obo/HP_0001644
T21 29498-29504 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T22 30012-30025 Phenotype denotes heart failure http://purl.obolibrary.org/obo/HP_0001635
T23 30277-30289 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T24 30922-30934 Phenotype denotes lung disease http://purl.obolibrary.org/obo/HP_0002088
T25 31011-31028 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T26 31030-31033 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T27 31036-31054 Phenotype denotes pulmonary fibrosis http://purl.obolibrary.org/obo/HP_0002206
T28 31066-31078 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T29 31090-31110 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T30 31191-31194 Phenotype denotes ALI http://www.orpha.net/ORDO/Orphanet_178320
T31 31268-31274 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T32 31281-31291 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T33 31293-31305 Phenotype denotes pancreatitis http://purl.obolibrary.org/obo/HP_0001733
T34 31463-31473 Phenotype denotes aspiration http://purl.obolibrary.org/obo/HP_0002835
T35 31514-31520 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T36 31599-31605 Phenotype denotes oedema http://purl.obolibrary.org/obo/HP_0000969
T37 32008-32014 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T38 32259-32265 Phenotype denotes asthma http://purl.obolibrary.org/obo/HP_0002099
T39 32408-32422 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T40 32764-32778 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T41 33466-33487 Phenotype denotes respiratory infective http://purl.obolibrary.org/obo/HP_0011947
T42 34539-34544 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T43 34553-34575 Phenotype denotes respiratory impairment http://purl.obolibrary.org/obo/HP_0002093
T44 34581-34590 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T45 54194-54206 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T46 54208-54231 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T47 54243-54260 Phenotype denotes diabetes mellitus http://purl.obolibrary.org/obo/HP_0000819
T48 54618-54630 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T49 54661-54684 Phenotype denotes cardiovascular diseases http://purl.obolibrary.org/obo/HP_0001626
T50 54834-54846 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T51 54856-54878 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T52 55268-55280 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T53 55382-55394 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T54 55422-55444 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T55 55551-55570 Phenotype denotes acute kidney injury http://purl.obolibrary.org/obo/HP_0001919
T56 55591-55596 Phenotype denotes shock http://purl.obolibrary.org/obo/HP_0031273
T57 55825-55832 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T58 55915-55922 Phenotype denotes obesity http://purl.obolibrary.org/obo/HP_0001513
T59 57735-57747 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T60 58158-58170 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T61 58172-58194 Phenotype denotes cardiovascular disease http://purl.obolibrary.org/obo/HP_0001626
T62 58814-58834 Phenotype denotes respiratory distress http://purl.obolibrary.org/obo/HP_0002098
T63 59208-59220 Phenotype denotes hypertension http://purl.obolibrary.org/obo/HP_0000822
T64 60812-60821 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T65 61112-61124 Phenotype denotes sudden death http://purl.obolibrary.org/obo/HP_0001699
T66 61614-61623 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T67 62057-62071 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T68 62207-62221 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T69 63649-63663 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T70 64078-64089 Phenotype denotes lymphopenia http://purl.obolibrary.org/obo/HP_0001888
T71 64119-64128 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T72 65318-65332 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T73 67491-67511 Phenotype denotes vitamin D deficiency http://purl.obolibrary.org/obo/HP_0100512
T74 68010-68030 Phenotype denotes pulmonary infections http://purl.obolibrary.org/obo/HP_0006532
T75 68087-68109 Phenotype denotes respiratory infections http://purl.obolibrary.org/obo/HP_0011947
T76 68216-68230 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041
T77 70276-70293 Phenotype denotes acute lung injury http://www.orpha.net/ORDO/Orphanet_178320
T78 73431-73438 Phenotype denotes Obesity http://purl.obolibrary.org/obo/HP_0001513
T79 73543-73567 Phenotype denotes increased blood pressure http://purl.obolibrary.org/obo/HP_0032263
T80 73649-73666 Phenotype denotes Alzheimer disease http://purl.obolibrary.org/obo/HP_0002511
T81 73840-73846 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T82 73874-73880 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T83 74011-74023 Phenotype denotes colon cancer http://purl.obolibrary.org/obo/HP_0003003
T84 74080-74104 Phenotype denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/HP_0001402
T85 74333-74338 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T86 74390-74416 Phenotype denotes Non-Small Cell Lung Cancer http://purl.obolibrary.org/obo/HP_0030358
T87 74418-74423 Phenotype denotes NSCLC http://purl.obolibrary.org/obo/HP_0030358
T88 74647-74652 Phenotype denotes NSCLC http://purl.obolibrary.org/obo/HP_0030358
T89 74719-74730 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526
T90 74982-74988 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T91 75086-75092 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T92 75312-75321 Phenotype denotes carcinoma http://purl.obolibrary.org/obo/HP_0030731
T93 75330-75355 Phenotype denotes pancreatic adenocarcinoma http://purl.obolibrary.org/obo/HP_0006725
T94 75429-75448 Phenotype denotes lung adenocarcinoma http://purl.obolibrary.org/obo/HP_0030078
T95 75513-75536 Phenotype denotes squamous cell carcinoma http://purl.obolibrary.org/obo/HP_0002860
T96 75633-75650 Phenotype denotes thyroid carcinoma http://purl.obolibrary.org/obo/HP_0002890
T97 75652-75656 Phenotype denotes THCA http://purl.obolibrary.org/obo/HP_0002890
T98 76411-76416 Phenotype denotes tumor http://purl.obolibrary.org/obo/HP_0002664
T99 76531-76552 Phenotype denotes endometrial carcinoma http://purl.obolibrary.org/obo/HP_0012114

LitCovid-sample-Glycan

Id Subject Object Predicate Lexical cue
T1 13558-13560 http://rdf.glyconavi.org/CarTNa/CarTNa66/trivialname denotes H3
T2 13814-13816 http://rdf.glyconavi.org/CarTNa/CarTNa66/trivialname denotes H3
T3 14630-14632 http://rdf.glyconavi.org/CarTNa/CarTNa66/trivialname denotes H3
T4 44491-44494 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T5 44491-44494 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T6 44491-44494 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T7 44491-44494 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T8 44491-44494 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T9 44491-44494 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T10 44491-44494 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T11 44491-44494 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T12 44491-44494 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T13 44491-44494 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non
T14 47365-47368 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T15 47365-47368 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T16 47365-47368 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T17 47365-47368 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T18 47365-47368 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T19 47365-47368 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T20 47365-47368 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T21 47365-47368 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T22 47365-47368 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T23 47365-47368 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non
T24 73302-73309 http://rdf.glyconavi.org/CarTNa/CarTNa210/trivialname denotes glucose
T25 74390-74393 https://glytoucan.org/Structures/Glycans/G02780QX denotes Non
T26 74390-74393 https://glytoucan.org/Structures/Glycans/G18425DX denotes Non
T27 74390-74393 https://glytoucan.org/Structures/Glycans/G18630JE denotes Non
T28 74390-74393 https://glytoucan.org/Structures/Glycans/G87301QZ denotes Non
T29 74390-74393 https://glytoucan.org/Structures/Glycans/G01004IT denotes Non
T30 74390-74393 https://glytoucan.org/Structures/Glycans/G39790GW denotes Non
T31 74390-74393 https://glytoucan.org/Structures/Glycans/G68183GR denotes Non
T32 74390-74393 https://glytoucan.org/Structures/Glycans/G42928BB denotes Non
T33 74390-74393 https://glytoucan.org/Structures/Glycans/G51134HC denotes Non
T34 74390-74393 https://glytoucan.org/Structures/Glycans/G54702VY denotes Non
T35 78451-78454 https://glytoucan.org/Structures/Glycans/G05518TD denotes All

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2 0-4 Gene denotes ACE2 Gene:59272
3 19-29 Species denotes SARS-CoV-2 Tax:2697049
46 78-109 Gene denotes Angiotensin-converting enzyme 2 Gene:59272
47 111-115 Gene denotes ACE2 Gene:59272
48 131-134 Gene denotes ACE Gene:1636
49 202-205 Gene denotes ACE Gene:1636
50 207-211 Gene denotes ACE2 Gene:59272
51 296-300 Gene denotes ACE2 Gene:59272
52 425-429 Gene denotes ACE2 Gene:59272
53 549-553 Gene denotes ACE2 Gene:59272
54 667-671 Gene denotes ACE2 Gene:59272
55 766-770 Gene denotes ACE2 Gene:59272
56 1085-1089 Gene denotes ACE2 Gene:59272
57 1154-1158 Gene denotes ACE2 Gene:59272
58 1399-1403 Gene denotes ACE2 Gene:59272
59 1520-1523 Gene denotes ACE Gene:1636
60 1589-1593 Gene denotes ACE2 Gene:59272
61 1854-1858 Gene denotes ACE2 Gene:59272
62 2058-2062 Gene denotes ACE2 Gene:59272
63 2172-2176 Gene denotes ACE2 Gene:59272
64 2305-2309 Gene denotes ACE2 Gene:59272
65 2428-2432 Gene denotes ACE2 Gene:59272
66 1307-1315 Gene denotes envelope Gene:43740570
67 454-458 Gene denotes post Gene:159371
68 347-351 Gene denotes post Gene:159371
69 1335-1343 Gene denotes membrane Gene:43740571
70 539-547 Gene denotes membrane Gene:43740571
71 583-592 Species denotes mammalian Tax:9606
72 847-866 Species denotes SARS)-coronaviruses Tax:694009
73 889-898 Species denotes SARS-CoV2 Tax:2697049
74 1075-1084 Species denotes SARS-CoV2 Tax:2697049
75 1131-1140 Species denotes SARS-CoV2 Tax:2697049
76 1407-1416 Species denotes SARS-CoV2 Tax:2697049
77 277-294 Disease denotes lung inflammation MESH:D011014
78 621-642 Disease denotes cardiovascular system MESH:D002318
79 812-845 Disease denotes severe acute respiratory syndrome MESH:D045169
80 919-943 Disease denotes COronaVIrus Disease 2019 MESH:C000657245
81 945-953 Disease denotes COVID-19 MESH:C000657245
82 979-987 Disease denotes COVID-19 MESH:C000657245
83 1486-1498 Disease denotes hypertension MESH:D006973
84 1626-1646 Disease denotes SARS-CoV-2 infection MESH:C000657245
85 1843-1852 Disease denotes infection MESH:D007239
86 2017-2025 Disease denotes COVID-19 MESH:C000657245
87 2507-2515 Disease denotes COVID-19 MESH:C000657245
98 2592-2621 Gene denotes Angiotensin-converting enzyme Gene:1636
99 2623-2626 Gene denotes ACE Gene:1636
100 2741-2754 Gene denotes angiotensin I Gene:183
101 2759-2769 Gene denotes bradykinin Gene:3827
102 2817-2820 Gene denotes ACE Gene:1636
103 2921-2924 Gene denotes ACE Gene:1636
104 3057-3060 Gene denotes ACE Gene:1636
105 2956-2978 Disease denotes cardiovascular disease MESH:D002318
106 3002-3014 Disease denotes hypertension MESH:D006973
107 3019-3043 Disease denotes congestive heart failure MESH:D006333
122 3176-3180 Gene denotes ACE2 Gene:59272
123 3283-3296 Gene denotes angiotensin I Gene:183
124 3349-3352 Gene denotes ACE Gene:1636
125 3438-3442 Gene denotes ACE2 Gene:59272
126 3476-3480 Gene denotes ACE2 Gene:59272
127 3534-3537 Gene denotes ACE Gene:1636
128 3573-3577 Gene denotes ACE2 Gene:59272
129 3732-3736 Gene denotes ACE2 Gene:59272
130 3873-3877 Gene denotes ACE2 Gene:59272
131 3723-3731 Gene denotes membrane Gene:43740571
132 3636-3644 Species denotes SARS-CoV Tax:694009
133 3771-3781 Species denotes SARS-CoV-2 Tax:2697049
134 3142-3145 Gene denotes ACE Gene:11421
135 3823-3831 Disease denotes COVID-19 MESH:C000657245
144 4128-4132 Gene denotes ACE2 Gene:59272
145 4248-4252 Gene denotes ACE2 Gene:59272
146 4268-4272 Gene denotes ACE2 Gene:59272
147 4290-4300 Species denotes SARS-CoV-2 Tax:2697049
148 3953-3965 Disease denotes Hypertension MESH:D006973
149 4011-4019 Disease denotes COVID-19 MESH:C000657245
150 4085-4097 Disease denotes hypertension MESH:D006973
151 4104-4116 Disease denotes hypertensive MESH:D006973
153 4452-4456 Gene denotes ACE2 Gene:59272
156 4655-4658 Gene denotes ACE Gene:1636
157 4670-4674 Gene denotes ACE2 Gene:59272
167 4691-4720 Gene denotes Angiotensin-converting enzyme Gene:1636
168 4722-4725 Gene denotes ACE Gene:1636
169 4897-4900 Gene denotes ACE Gene:1636
170 4902-4906 Gene denotes tACE Gene:6868
171 5050-5053 Gene denotes ACE Gene:1636
172 4873-4876 Gene denotes ACE Gene:1636
173 5003-5011 Gene denotes membrane Gene:43740571
174 4685-4690 Species denotes Human Tax:9606
175 4745-4754 Chemical denotes gluzincin
191 5170-5173 Gene denotes ACE Gene:1636
192 5418-5421 Gene denotes ACE Gene:1636
193 5547-5560 Gene denotes angiotensin I Gene:183
194 5565-5575 Gene denotes bradykinin Gene:3827
195 5611-5614 Gene denotes ACE Gene:1636
196 5708-5721 Gene denotes angiotensin I Gene:183
197 5734-5748 Gene denotes angiotensin II Gene:183
198 5834-5837 Gene denotes ACE Gene:1636
199 5880-5890 Gene denotes bradykinin Gene:3827
200 5956-5959 Gene denotes ACE Gene:1636
201 5261-5284 Chemical denotes angiotensin-aldosterone
202 5286-5290 Chemical denotes RAAS
203 6023-6027 Chemical denotes salt MESH:D012492
204 5306-5329 Disease denotes cardiovascular diseases MESH:D002318
205 5915-5926 Disease denotes hypotensive MESH:D007022
228 6078-6081 Gene denotes ACE Gene:1636
229 6357-6360 Gene denotes ACE Gene:1636
230 6516-6519 Gene denotes ACE Gene:1636
231 6728-6731 Gene denotes ACE Gene:1636
232 7056-7059 Gene denotes ACE Gene:1636
233 7075-7079 Gene denotes ACE2 Gene:59272
234 7252-7256 Gene denotes ACE2 Gene:59272
235 7329-7332 Gene denotes ACE Gene:1636
236 7360-7363 Gene denotes ACE Gene:1636
237 7365-7369 Gene denotes ACE2 Gene:59272
238 7436-7440 Gene denotes ACE2 Gene:59272
239 7525-7529 Gene denotes ACE2 Gene:59272
240 7606-7610 Gene denotes ACE2 Gene:59272
241 6148-6153 Species denotes human Tax:9606
242 6351-6356 Species denotes human Tax:9606
243 6620-6625 Species denotes human Tax:9606
244 7045-7050 Species denotes human Tax:9606
245 7206-7211 Species denotes woman Tax:9606
246 6793-6802 Chemical denotes glutamate MESH:D018698
247 6626-6634 Disease denotes lymphoma MESH:D008223
248 7014-7027 Disease denotes heart failure MESH:D006333
249 7217-7250 Disease denotes idiopathic dilated cardiomyopathy MESH:C536277
251 7723-7727 Gene denotes ACE2 Gene:59272
260 7805-7809 Gene denotes ACE2 Gene:59272
261 7884-7887 Gene denotes ACE Gene:1636
262 7943-7947 Gene denotes ACE2 Gene:59272
263 7974-7977 Gene denotes ACE Gene:1636
264 7989-7993 Gene denotes ACE2 Gene:59272
265 8063-8067 Gene denotes ACE2 Gene:59272
266 8168-8180 Disease denotes hypertension MESH:D006973
267 8185-8207 Disease denotes cardiovascular disease MESH:D002318
282 8279-8283 Gene denotes ACE2 Gene:59272
283 8428-8431 Gene denotes ACE Gene:1636
284 8436-8440 Gene denotes ACE2 Gene:59272
285 8513-8516 Gene denotes ACE Gene:1636
286 8538-8542 Gene denotes ACE2 Gene:59272
287 8608-8612 Gene denotes ACE2 Gene:59272
288 8643-8656 Gene denotes angiotensin I Gene:183
289 8660-8674 Gene denotes angiotensin II Gene:183
290 8695-8705 Gene denotes bradykinin Gene:3827
291 8717-8721 Gene denotes ACE2 Gene:59272
292 8740-8743 Gene denotes ACE Gene:1636
293 8744-8754 Chemical denotes inhibitors
294 8761-8771 Chemical denotes lisinopril MESH:D017706
295 8776-8785 Chemical denotes captopril MESH:D002216
310 9026-9030 Gene denotes ACE2 Gene:59272
311 9119-9123 Gene denotes ACE2 Gene:59272
312 9275-9279 Gene denotes ACE2 Gene:59272
313 9711-9714 Gene denotes ACE Gene:1636
314 9719-9723 Gene denotes ACE2 Gene:59272
315 9825-9829 Gene denotes ACE2 Gene:59272
316 9922-9925 Gene denotes ACE Gene:1636
317 9956-9960 Gene denotes ACE2 Gene:59272
318 10078-10082 Gene denotes ACE2 Gene:59272
319 10175-10185 Gene denotes collectrin Gene:57393
320 10143-10146 Gene denotes ACE Gene:1636
321 10261-10269 Gene denotes membrane Gene:43740571
322 9912-9918 Chemical denotes Gln281
323 9946-9952 Chemical denotes Arg273
327 10322-10326 Gene denotes ACE2 Gene:59272
328 46911-46914 Gene denotes PDB Gene:5131
329 10379-10389 Gene denotes collectrin Gene:57393
332 10728-10732 Gene denotes Post Gene:159371
333 10702-10706 Gene denotes Post Gene:159371
337 10786-10790 Gene denotes ACE2 Gene:59272
338 10849-10853 Gene denotes ACE2 Gene:59272
339 11133-11137 Gene denotes ACE2 Gene:59272
369 11531-11535 Gene denotes ACE2 Gene:59272
370 11643-11647 Gene denotes ACE2 Gene:59272
371 11781-11785 Gene denotes ACE2 Gene:59272
372 11901-11905 Gene denotes ACE2 Gene:59272
373 11960-11964 Gene denotes ACE2 Gene:59272
374 12054-12058 Gene denotes ACE2 Gene:59272
375 12159-12162 Gene denotes ACE Gene:1636
376 12202-12207 Gene denotes renin Gene:5972
377 12404-12408 Gene denotes ACE2 Gene:59272
378 12432-12435 Gene denotes ACE Gene:1636
379 12501-12504 Gene denotes ERα Gene:2099
380 12814-12845 Gene denotes Estrogen Related Receptor alpha Gene:2101
381 12847-12851 Gene denotes ERRα Gene:2101
382 12869-12872 Gene denotes ERα Gene:2099
383 12940-12944 Gene denotes ACE2 Gene:59272
384 13108-13112 Gene denotes ACE2 Gene:59272
385 11351-11356 Species denotes human Tax:9606
386 12091-12096 Species denotes human Tax:9606
387 12538-12541 Gene denotes ERα Gene:2099
388 11460-11473 Chemical denotes 17β-estradiol MESH:D004958
389 11475-11477 Chemical denotes E2 MESH:D004958
390 11501-11508 Chemical denotes steroid MESH:D013256
391 11626-11628 Chemical denotes E2 MESH:D004958
392 12041-12043 Chemical denotes E2 MESH:D004958
393 12470-12472 Chemical denotes E2 MESH:D004958
394 11873-11881 Disease denotes COVID-19 MESH:C000657245
395 11916-11936 Disease denotes SARS-CoV-2 infection MESH:C000657245
396 11969-11977 Disease denotes COVID-19 MESH:C000657245
397 12324-12341 Disease denotes myocardial stress MESH:D000079225
420 13268-13272 Gene denotes ACE2 Gene:59272
421 13345-13349 Gene denotes ACE2 Gene:59272
422 13513-13517 Gene denotes ACE2 Gene:59272
423 13551-13554 Gene denotes K27 Gene:342574
424 13737-13741 Gene denotes PRC1 Gene:9055
425 13908-13912 Gene denotes PRC1 Gene:9055
426 14178-14182 Gene denotes EZH2 Gene:2146
427 14242-14246 Gene denotes ACE2 Gene:59272
428 14267-14271 Gene denotes ACE2 Gene:59272
429 14323-14327 Gene denotes EZH2 Gene:2146
430 14391-14395 Gene denotes EZH2 Gene:2146
431 14411-14415 Gene denotes ACE2 Gene:59272
432 14488-14492 Gene denotes EZH2 Gene:2146
433 14568-14572 Gene denotes ACE2 Gene:59272
434 14693-14697 Gene denotes ACE2 Gene:59272
435 14852-14856 Gene denotes ACE2 Gene:59272
436 14286-14291 Species denotes human Tax:9606
437 14585-14590 Species denotes human Tax:9606
438 14630-14632 Chemical denotes H3 MESH:C012616
439 14782-14794 Disease denotes hypertension MESH:D006973
440 14796-14804 Disease denotes diabetes MESH:D003920
441 14810-14842 Disease denotes chronic obstructive lung disease MESH:D029424
461 14981-14985 Gene denotes ACE2 Gene:59272
462 15042-15046 Gene denotes ACE2 Gene:59272
463 15297-15301 Gene denotes ACE2 Gene:59272
464 15510-15514 Gene denotes ACE2 Gene:59272
465 15600-15604 Gene denotes ACE2 Gene:59272
466 15696-15700 Gene denotes ACE2 Gene:59272
467 15869-15873 Gene denotes ACE2 Gene:59272
468 15935-15953 Gene denotes Vitamin D receptor Gene:7421
469 15955-15958 Gene denotes VDR Gene:7421
470 16024-16028 Gene denotes ACE2 Gene:59272
471 16049-16052 Gene denotes VDR Gene:7421
472 16083-16087 Gene denotes ACE2 Gene:59272
473 16189-16193 Gene denotes ACE2 Gene:59272
474 15687-15695 Species denotes children Tax:9606
475 16227-16237 Species denotes Sars-CoV-2 Tax:2697049
476 15856-15865 Chemical denotes Vitamin D MESH:D014807
477 16158-16167 Chemical denotes Vitamin D MESH:D014807
478 15557-15563 Disease denotes tumors MESH:D009369
479 16171-16179 Disease denotes COVID-19 MESH:C000657245
487 16283-16286 Gene denotes ACE Gene:1636
488 16287-16291 Gene denotes ACE2 Gene:59272
489 16489-16493 Gene denotes Brg1 Gene:6597
490 16522-16527 Gene denotes FoxM1 Gene:2305
491 16576-16580 Gene denotes ACE2 Gene:59272
492 16581-16584 Gene denotes ACE Gene:1636
493 16622-16641 Disease denotes cardiac hypertrophy MESH:D006332
498 16799-16806 Gene denotes miR-421 Gene:693122
499 16821-16825 Gene denotes ACE2 Gene:59272
500 16868-16875 Gene denotes miR-421 Gene:693122
501 16886-16890 Gene denotes ACE2 Gene:59272
521 17064-17068 Gene denotes ACE2 Gene:59272
522 17210-17214 Gene denotes ACE2 Gene:59272
523 17286-17290 Gene denotes ACE2 Gene:59272
524 17395-17399 Gene denotes ACE2 Gene:59272
525 17546-17550 Gene denotes ACE2 Gene:59272
526 17637-17641 Gene denotes ACE2 Gene:59272
527 17693-17699 Gene denotes Ang II Gene:24179
528 17710-17716 Gene denotes ADAM17 Gene:6868
529 17752-17756 Gene denotes ACE2 Gene:59272
530 17858-17862 Gene denotes ACE2 Gene:59272
531 17977-17983 Gene denotes ADAM17 Gene:6868
532 18018-18022 Gene denotes ACE2 Gene:59272
533 17582-17592 Gene denotes calmodulin Gene:801
534 17519-17529 Gene denotes calmodulin Gene:801
535 17077-17081 Gene denotes post Gene:159371
536 16993-16997 Gene denotes post Gene:159371
537 17130-17138 Gene denotes membrane Gene:43740571
538 18056-18066 Species denotes Sars-CoV-2 Tax:2697049
539 17889-17911 Disease denotes myocardial dysfunction MESH:D009202
543 18183-18187 Gene denotes ACE2 Gene:59272
544 18141-18145 Gene denotes post Gene:159371
545 18115-18119 Gene denotes post Gene:159371
548 18285-18289 Gene denotes ACE2 Gene:59272
549 18254-18258 Gene denotes post Gene:159371
561 18409-18413 Gene denotes ACE2 Gene:59272
562 18525-18529 Gene denotes ACE2 Gene:59272
563 18752-18756 Gene denotes ACE2 Gene:59272
564 19061-19065 Gene denotes ACE2 Gene:59272
565 19541-19545 Gene denotes ACE2 Gene:59272
566 19587-19591 Gene denotes ACE2 Gene:59272
567 18730-18731 Gene denotes S Gene:43740568
568 18476-18485 Species denotes mammalian Tax:9606
569 19643-19648 Species denotes human Tax:9606
570 18562-18583 Disease denotes cardiovascular system MESH:D002318
571 19649-19664 Disease denotes hemato-lymphoid MESH:D008224
575 19920-19924 Gene denotes ACE2 Gene:59272
576 20266-20270 Gene denotes ACE2 Gene:59272
577 20253-20258 Species denotes human Tax:9606
581 20458-20462 Gene denotes ACE2 Gene:59272
582 20504-20513 Species denotes mammalian Tax:9606
583 20525-20530 Species denotes human Tax:9606
599 21130-21134 Gene denotes ACE2 Gene:59272
600 21273-21277 Gene denotes ACE2 Gene:59272
601 21701-21705 Gene denotes ACE2 Gene:59272
602 21753-21757 Gene denotes ACE2 Gene:59272
603 21915-21919 Gene denotes ACE2 Gene:70008
604 22302-22305 Gene denotes age Gene:5973
605 22222-22225 Gene denotes age Gene:5973
606 21294-21299 Species denotes human Tax:9606
607 21626-21636 Species denotes SARS-CoV-2 Tax:2697049
608 22018-22023 Species denotes mouse Tax:10090
609 22025-22028 Species denotes rat Tax:10116
610 22035-22041 Species denotes ferret Tax:9669
611 22054-22059 Species denotes human Tax:9606
612 21645-21654 Disease denotes infection MESH:D007239
613 21710-21718 Disease denotes COVID-19 MESH:C000657245
620 22372-22376 Gene denotes ACE2 Gene:59272
621 22637-22641 Gene denotes ACE2 Gene:59272
622 23049-23053 Gene denotes ACE2 Gene:59272
623 22820-22825 Disease denotes colon MESH:D003110
624 22888-22893 Disease denotes colon MESH:D003110
625 23093-23113 Disease denotes endocrine pancreatic MESH:D010195
634 23204-23208 Gene denotes ACE2 Gene:70008
635 23308-23312 Gene denotes ACE2 Gene:70008
636 23986-23990 Gene denotes ACE2 Gene:70008
637 24137-24141 Gene denotes ACE2 Gene:70008
638 23243-23248 Species denotes mouse Tax:10090
639 23265-23278 Disease denotes telencephalon
640 23507-23535 Disease denotes hypothalamic paraventricular MESH:D007027
641 23550-23558 Disease denotes postrema
648 24332-24336 Gene denotes ACE2 Gene:59272
649 24421-24425 Gene denotes ACE2 Gene:59272
650 24568-24572 Gene denotes ACE2 Gene:59272
651 24407-24412 Species denotes human Tax:9606
652 24595-24600 Species denotes human Tax:9606
653 24601-24608 Disease denotes ovaries MESH:D010051
656 24826-24830 Gene denotes ACE2 Gene:59272
657 24957-24962 Species denotes human Tax:9606
666 25044-25048 Gene denotes ACE2 Gene:59272
667 25231-25235 Gene denotes ACE2 Gene:59272
668 25341-25345 Gene denotes ACE2 Gene:59272
669 25409-25413 Gene denotes ACE2 Gene:59272
670 25578-25582 Gene denotes ACE2 Gene:59272
671 25436-25444 Gene denotes membrane Gene:43740571
672 25032-25037 Species denotes human Tax:9606
673 25448-25453 Species denotes human Tax:9606
675 25680-25684 Gene denotes ACE2 Gene:59272
688 25754-25758 Gene denotes ACE2 Gene:59272
689 25873-25877 Gene denotes ACE2 Gene:59272
690 26002-26006 Gene denotes ACE2 Gene:59272
691 26096-26100 Gene denotes ACE2 Gene:59272
692 26118-26121 Gene denotes ACE Gene:1636
693 26170-26184 Gene denotes angiotensin II Gene:183
694 26219-26223 Gene denotes ACE2 Gene:70008
695 26300-26304 Gene denotes ACE2 Gene:70008
696 26478-26481 Gene denotes ACE Gene:1636
697 26584-26588 Gene denotes ACE2 Gene:70008
698 26287-26292 Species denotes mouse Tax:10090
699 26267-26277 Species denotes transgenic Tax:10090
705 26711-26715 Gene denotes ACE2 Gene:59272
706 26829-26833 Gene denotes ACE2 Gene:59272
707 26943-26946 Gene denotes ACE Gene:1636
708 27168-27172 Gene denotes MasR Gene:116511
709 27082-27086 Gene denotes MasR Gene:116511
718 27254-27258 Gene denotes ACE2 Gene:59272
719 27280-27284 Gene denotes ACE2 Gene:59272
720 27343-27349 Gene denotes ANG II Gene:24179
721 27382-27395 Gene denotes angiotensin I Gene:183
722 27473-27476 Gene denotes ACE Gene:1636
723 27582-27586 Gene denotes ACE2 Gene:59272
724 27626-27631 Gene denotes BKB1R Gene:623
725 27495-27499 Gene denotes MasR Gene:116511
737 27743-27747 Gene denotes ACE2 Gene:59272
738 28100-28104 Gene denotes ACE2 Gene:59272
739 28676-28680 Gene denotes ACE2 Gene:59272
740 27755-27759 Gene denotes MasR Gene:116511
741 28725-28730 Species denotes human Tax:9606
742 28742-28750 Species denotes patients Tax:9606
743 28164-28176 Chemical denotes nitric oxide MESH:D009569
744 28411-28433 Disease denotes myocardial hypertrophy MESH:D006332
745 28481-28502 Disease denotes myocardial infarction MESH:D009203
746 28763-28771 Disease denotes ischemic MESH:D007511
747 28775-28797 Disease denotes dilated cardiomyopathy MESH:D002311
760 28877-28881 Gene denotes ACE2 Gene:59272
761 28931-28935 Gene denotes ACE2 Gene:59272
762 29156-29160 Gene denotes ACE2 Gene:59272
763 29323-29327 Gene denotes MrgD Gene:116512
764 29385-29389 Gene denotes MrgD Gene:116512
765 28965-28978 Chemical denotes Angiotensin A
766 28980-28985 Chemical denotes Ang-A
767 29176-29183 Chemical denotes Ala-Ang
768 29204-29214 Chemical denotes alamandine MESH:C581752
769 29440-29450 Chemical denotes alamandine MESH:C581752
770 29424-29435 Disease denotes cardiopathy MESH:C536187
771 29498-29504 Disease denotes sepsis MESH:D018805
777 29535-29538 Gene denotes ACE Gene:1636
778 29540-29544 Gene denotes ACE2 Gene:59272
779 29562-29572 Gene denotes bradykinin Gene:3827
780 29604-29614 Gene denotes bradykinin Gene:3827
781 29692-29714 Gene denotes B1 bradykinin receptor Gene:623
794 29779-29783 Gene denotes ACE2 Gene:59272
795 29806-29817 Gene denotes neurotensin Gene:4922
796 29893-29899 Gene denotes apelin Gene:8862
797 29944-29948 Gene denotes ACE2 Gene:59272
798 30070-30074 Gene denotes ACE2 Gene:59272
799 30198-30202 Gene denotes ACE2 Gene:59272
800 30207-30213 Gene denotes Apelin Gene:8862
801 30103-30109 Gene denotes apelin Gene:8862
802 29819-29830 Chemical denotes dynorphin A
803 29843-29850 Chemical denotes ghrelin MESH:D054439
804 30012-30025 Disease denotes heart failure MESH:D006333
805 30277-30289 Disease denotes hypertension MESH:D006973
811 30376-30380 Gene denotes ACE2 Gene:59272
812 30508-30511 Gene denotes ACE Gene:1636
813 30598-30602 Gene denotes MrgD Gene:116512
814 30575-30579 Gene denotes MasR Gene:116511
815 30587-30597 Chemical denotes Alamandine MESH:C581752
818 30691-30695 Gene denotes ACE2 Gene:59272
819 30700-30711 Disease denotes Lung Injury MESH:D055370
831 30712-30716 Gene denotes ACE2 Gene:59272
832 30871-30875 Gene denotes ACE2 Gene:59272
833 30969-30972 Gene denotes ACE Gene:1636
834 30977-30991 Gene denotes angiotensin II Gene:183
835 30787-30802 Disease denotes pulmonary small MESH:D008171
836 30922-30934 Disease denotes lung disease MESH:D008171
837 31011-31028 Disease denotes acute lung injury MESH:D055371
838 31036-31054 Disease denotes pulmonary fibrosis MESH:D011658
839 31056-31078 Disease denotes pulmonary hypertension MESH:D006976
840 31084-31119 Disease denotes acute respiratory distress syndrome MESH:D012128
841 31121-31125 Disease denotes ARDS MESH:D012128
858 31404-31408 Gene denotes ACE2 Gene:70008
859 31817-31821 Gene denotes ACE2 Gene:70008
860 31307-31314 Species denotes anthrax Tax:1392
861 31350-31354 Species denotes H5N1 Tax:102793
862 31418-31422 Species denotes mice Tax:10090
863 31154-31158 Disease denotes ARDS MESH:D012128
864 31228-31239 Disease denotes lung injury MESH:D055370
865 31268-31274 Disease denotes sepsis MESH:D018805
866 31293-31305 Disease denotes pancreatitis MESH:D010195
867 31319-31335 Disease denotes virus infections MESH:D001102
868 31442-31446 Disease denotes ARDS MESH:D012128
869 31514-31520 Disease denotes sepsis MESH:D018805
870 31539-31543 Disease denotes ARDS MESH:D012128
871 31594-31605 Disease denotes lung oedema MESH:D004487
872 31627-31639 Disease denotes inflammation MESH:D007249
873 31663-31697 Disease denotes impairment of respiratory function MESH:D012131
883 31889-31893 Gene denotes ACE2 Gene:59272
884 31939-31943 Gene denotes MasR Gene:116511
885 32458-32486 Gene denotes transforming growth factor β Gene:7124
886 32488-32494 Gene denotes TGF- β Gene:7039
887 31910-31927 Disease denotes lung inflammation MESH:D011014
888 31999-32014 Disease denotes allergic asthma MESH:D001249
889 32063-32075 Disease denotes inflammation MESH:D007249
890 32077-32085 Disease denotes fibrosis MESH:D005355
891 32259-32265 Disease denotes asthma MESH:D001249
900 32562-32566 Gene denotes ACE2 Gene:59272
901 32629-32634 Gene denotes BKB1R Gene:623
902 32660-32664 Gene denotes ACE2 Gene:70008
903 32780-32785 Gene denotes CXCL5 Gene:20311
904 32787-32791 Gene denotes MIP2 Gene:20310
905 32801-32806 Gene denotes TNF-α Gene:21926
906 32677-32682 Species denotes mouse Tax:10090
907 32587-32604 Disease denotes lung inflammation MESH:D011014
923 32871-32874 Gene denotes ACE Gene:1636
924 32875-32879 Gene denotes ACE2 Gene:59272
925 32971-32974 Gene denotes ACE Gene:1636
926 32988-32991 Gene denotes ACE Gene:1636
927 33022-33025 Gene denotes ACE Gene:1636
928 33049-33053 Gene denotes ACE2 Gene:59272
929 33180-33194 Gene denotes angiotensin II Gene:183
930 32864-32869 Species denotes human Tax:9606
931 33217-33225 Species denotes patients Tax:9606
932 33246-33263 Species denotes influenza viruses Tax:11308
933 33264-33268 Species denotes H5N1 Tax:102793
934 33086-33090 Disease denotes ARDS MESH:D012128
935 33110-33119 Disease denotes mortality MESH:D003643
936 33226-33234 Disease denotes infected MESH:D007239
937 33275-33277 CellLine denotes N9 CVCL:0452
940 33386-33390 Gene denotes ACE2 Gene:59272
941 33395-33403 Disease denotes COVID-19 MESH:C000657245
950 33424-33428 Gene denotes ACE2 Gene:59272
951 34288-34292 Gene denotes ACE2 Gene:59272
952 33897-33898 Gene denotes S Gene:43740568
953 33741-33752 Species denotes coronavirus Tax:11118
954 33770-33778 Species denotes SARS-CoV Tax:694009
955 33466-33495 Disease denotes respiratory infective disease MESH:D012141
956 34112-34163 Disease denotes SARS-CoV efficiently infected African Monkey kidney MESH:C000657245
957 34179-34181 CellLine denotes E6 CVCL:4582
976 35079-35083 Gene denotes ACE2 Gene:59272
977 35206-35210 Gene denotes ACE2 Gene:59272
978 34312-34320 Species denotes SARS-CoV Tax:694009
979 34441-34452 Species denotes coronavirus Tax:11118
980 34466-34471 Species denotes human Tax:9606
981 34621-34636 Species denotes new coronavirus Tax:2697049
982 34658-34668 Species denotes SARS-CoV-2 Tax:2697049
983 34702-34710 Species denotes SARS-CoV Tax:694009
984 34843-34853 Species denotes SARS-CoV-2 Tax:2697049
985 35055-35065 Species denotes SARS-CoV-2 Tax:2697049
986 35202-35205 Species denotes CoV Tax:11118
987 34376-34386 Disease denotes infections MESH:D007239
988 34539-34544 Disease denotes fever MESH:D005334
989 34553-34575 Disease denotes respiratory impairment MESH:D012131
990 34581-34590 Disease denotes pneumonia MESH:D011014
991 34768-34792 Disease denotes COronaVIrus Disease 2019 MESH:C000657245
992 35000-35008 Disease denotes COVID-19 MESH:C000657245
993 35107-35116 Disease denotes infection MESH:D007239
995 35267-35268 Gene denotes S Gene:43740568
1014 35333-35338 Gene denotes spike Gene:43740568
1015 35358-35366 Gene denotes membrane Gene:43740571
1016 35344-35352 Gene denotes envelope Gene:43740570
1017 36290-36291 Gene denotes S Gene:43740568
1018 35989-35990 Gene denotes S Gene:43740568
1019 35921-35922 Gene denotes S Gene:43740568
1020 35773-35781 Gene denotes membrane Gene:43740571
1021 35279-35290 Species denotes coronavirus Tax:11118
1022 35910-35920 Species denotes SARS-CoV-2 Tax:2697049
1023 35994-35999 Species denotes human Tax:9606
1024 36000-36008 Species denotes SARS-CoV Tax:694009
1025 36073-36083 Species denotes SARS-CoV-2 Tax:2697049
1026 36127-36135 Species denotes SARS-CoV Tax:694009
1027 36265-36273 Species denotes SARS-CoV Tax:694009
1028 36279-36289 Species denotes SARS-CoV-2 Tax:2697049
1029 36366-36374 Species denotes SARS-CoV Tax:694009
1030 36378-36388 Species denotes SARS-CoV-2 Tax:2697049
1031 35609-35625 Chemical denotes N-linked glycans
1035 36472-36483 Species denotes Coronavirus Tax:11118
1036 36551-36559 Species denotes SARS-CoV Tax:694009
1037 36564-36574 Species denotes SARS-CoV-2 Tax:2697049
1048 36803-36811 Gene denotes envelope Gene:43740570
1049 36580-36581 Gene denotes S Gene:43740568
1050 37878-37886 Gene denotes membrane Gene:43740571
1051 37574-37582 Gene denotes membrane Gene:43740571
1052 37089-37097 Species denotes SARS-CoV Tax:694009
1053 37113-37123 Species denotes SARS-CoV-2 Tax:2697049
1054 36711-36713 Gene denotes aa Gene:351
1055 36672-36674 Gene denotes aa Gene:351
1056 37515-37522 Chemical denotes glycine MESH:D005998
1057 37530-37537 Chemical denotes alanine MESH:D000409
1076 38087-38091 Gene denotes ACE2 Gene:59272
1077 38237-38241 Gene denotes ACE2 Gene:70008
1078 38427-38431 Gene denotes ACE2 Gene:59272
1079 38520-38525 Gene denotes hDPP4 Gene:1803
1080 38724-38728 Gene denotes ACE2 Gene:59272
1081 37959-37967 Species denotes SARS-CoV Tax:694009
1082 37972-37982 Species denotes SARS-CoV-2 Tax:2697049
1083 38194-38199 Species denotes human Tax:9606
1084 38217-38220 Species denotes pig Tax:9823
1085 38230-38235 Species denotes mouse Tax:10090
1086 38394-38404 Species denotes SARS-CoV-2 Tax:2697049
1087 38408-38416 Species denotes SARS-CoV Tax:694009
1088 38484-38489 Species denotes human Tax:9606
1089 38514-38518 Species denotes CoVs Tax:11118
1090 38543-38551 Species denotes MERS CoV Tax:1335626
1091 38556-38565 Species denotes HCoV-229E Tax:11137
1092 38705-38715 Species denotes SARS-CoV-2 Tax:2697049
1093 38370-38378 Disease denotes infected MESH:D007239
1097 38817-38825 Gene denotes membrane Gene:43740571
1098 38922-38930 Species denotes SARS-CoV Tax:694009
1099 38935-38945 Species denotes SARS-CoV-2 Tax:2697049
1109 39647-39648 Gene denotes S Gene:43740568
1110 39154-39155 Gene denotes S Gene:43740568
1111 40721-40725 Gene denotes post Gene:159371
1112 40219-40223 Gene denotes post Gene:159371
1113 40592-40600 Gene denotes membrane Gene:43740571
1114 39356-39364 Gene denotes membrane Gene:43740571
1115 39006-39014 Species denotes SARS-CoV Tax:694009
1116 39019-39029 Species denotes SARS-CoV-2 Tax:2697049
1117 40418-40420 Gene denotes aa Gene:351
1127 41920-41921 Gene denotes S Gene:43740568
1128 41320-41321 Gene denotes S Gene:43740568
1129 41266-41267 Gene denotes S Gene:43740568
1130 41886-41890 Gene denotes post Gene:159371
1131 42162-42170 Gene denotes membrane Gene:43740571
1132 42124-42132 Gene denotes membrane Gene:43740571
1133 42095-42103 Gene denotes membrane Gene:43740571
1134 41694-41702 Gene denotes membrane Gene:43740571
1135 41211-41222 Species denotes Coronavirus Tax:11118
1139 42501-42504 Gene denotes PDB Gene:5131
1140 42254-42255 Gene denotes S Gene:43740568
1141 42267-42277 Species denotes SARS-CoV-2 Tax:2697049
1163 42547-42551 Gene denotes ACE2 Gene:59272
1164 43392-43397 Gene denotes furin Gene:5045
1165 43474-43481 Gene denotes TMPRSS2 Gene:7113
1166 43629-43640 Gene denotes cathepsin L Gene:1514
1167 42948-42953 Gene denotes furin Gene:5045
1168 43184-43189 Gene denotes furin Gene:5045
1169 43119-43120 Gene denotes S Gene:43740568
1170 42565-42566 Gene denotes S Gene:43740568
1171 43956-43964 Gene denotes membrane Gene:43740571
1172 43903-43911 Gene denotes membrane Gene:43740571
1173 43516-43524 Gene denotes membrane Gene:43740571
1174 42648-42658 Species denotes SARS-CoV-2 Tax:2697049
1175 42722-42732 Species denotes SARS-CoV-2 Tax:2697049
1176 42756-42764 Species denotes SARS-CoV Tax:694009
1177 42786-42799 Species denotes coronaviruses Tax:11118
1178 43108-43118 Species denotes SARS-CoV-2 Tax:2697049
1179 43252-43260 Species denotes SARS-CoV Tax:694009
1180 43286-43296 Species denotes SARS-COV-2 Tax:2697049
1181 43738-43748 Species denotes SARS-CoV-2 Tax:2697049
1182 43402-43407 Gene denotes furin Gene:5045
1183 43791-43799 Disease denotes COVID-19 MESH:C000657245
1192 44386-44393 Gene denotes TMPRSS2 Gene:487770
1193 44188-44193 Gene denotes furin Gene:5045
1194 44041-44042 Gene denotes S Gene:43740568
1195 44661-44665 Gene denotes fuse Gene:2522
1196 44682-44690 Gene denotes membrane Gene:43740571
1197 44601-44609 Gene denotes membrane Gene:43740571
1198 44448-44456 Gene denotes membrane Gene:43740571
1199 44361-44369 Gene denotes membrane Gene:43740571
1201 44914-44924 Species denotes SARS-CoV-2 Tax:2697049
1217 45521-45525 Gene denotes ACE2 Gene:59272
1218 45629-45634 Gene denotes hDPP4 Gene:1803
1219 45674-45678 Gene denotes ACE2 Gene:59272
1220 45732-45736 Gene denotes ACE2 Gene:59272
1221 45610-45618 Gene denotes membrane Gene:43740571
1222 44958-44968 Species denotes SARS-CoV-2 Tax:2697049
1223 44973-44981 Species denotes SARS-CoV Tax:694009
1224 45049-45059 Species denotes SARS-CoV-2 Tax:2697049
1225 45090-45098 Species denotes SARS-CoV Tax:694009
1226 45100-45108 Species denotes SARS-CoV Tax:694009
1227 45226-45236 Species denotes SARS-CoV-2 Tax:2697049
1228 45283-45291 Species denotes SARS-CoV Tax:694009
1229 45399-45409 Species denotes SARS-CoV-2 Tax:2697049
1230 45455-45465 Species denotes SARS-CoV-2 Tax:2697049
1231 45555-45558 CellLine denotes HEK CVCL:M624
1248 46011-46013 Gene denotes β1 Gene:597
1249 46015-46017 Gene denotes β2 Gene:170589
1250 46019-46021 Gene denotes β3 Gene:28883
1251 46023-46025 Gene denotes β4 Gene:28898
1252 46027-46029 Gene denotes β7 Gene:28885
1253 46082-46084 Gene denotes β4 Gene:28898
1254 46161-46164 Gene denotes β2’ Gene:170589
1255 46153-46156 Gene denotes β1’ Gene:597
1256 46141-46143 Gene denotes β6 Gene:28873
1257 46134-46136 Gene denotes β5 Gene:28884
1258 46089-46091 Gene denotes β7 Gene:28885
1259 45786-45796 Species denotes SARS-CoV-2 Tax:2697049
1260 45893-45903 Species denotes SARS-CoV-2 Tax:2697049
1261 46323-46333 Species denotes SARS-COV-2 Tax:2697049
1262 46338-46346 Species denotes SARS-CoV Tax:694009
1263 46203-46212 Chemical denotes disulfide MESH:D004220
1271 46608-46612 Gene denotes ACE2 Gene:59272
1272 46679-46684 Gene denotes hACE2 Gene:59272
1273 46567-46572 Gene denotes spike Gene:43740568
1275 46869-46872 Gene denotes PDB Gene:5131
1276 46556-46566 Species denotes SARS-CoV-2 Tax:2697049
1277 46710-46720 Species denotes SARS-CoV-2 Tax:2697049
1301 46996-47000 Gene denotes ACE2 Gene:59272
1302 47315-47319 Gene denotes ACE2 Gene:59272
1303 47584-47588 Gene denotes ACE2 Gene:59272
1304 47816-47820 Gene denotes ACE2 Gene:59272
1305 47975-47979 Gene denotes ACE2 Gene:59272
1306 48498-48502 Gene denotes ACE2 Gene:59272
1307 48077-48078 Gene denotes S Gene:43740568
1308 48023-48024 Gene denotes S Gene:43740568
1309 47171-47172 Gene denotes S Gene:43740568
1310 46976-46986 Species denotes SARS-CoV-2 Tax:2697049
1311 47073-47083 Species denotes SARS-CoV-2 Tax:2697049
1312 47544-47554 Species denotes SARS-CoV-2 Tax:2697049
1313 47613-47621 Species denotes SARS-CoV Tax:694009
1314 47793-47803 Species denotes SARS-CoV-2 Tax:2697049
1315 47841-47851 Species denotes SARS-CoV-2 Tax:2697049
1316 47875-47883 Species denotes SARS-CoV Tax:694009
1317 48012-48022 Species denotes SARS-CoV-2 Tax:2697049
1318 48139-48149 Species denotes SARS-CoV-2 Tax:2697049
1319 48208-48216 Species denotes SARS-CoV Tax:694009
1320 48386-48396 Species denotes SARS-CoV-2 Tax:2697049
1321 48401-48409 Species denotes SARS-CoV Tax:694009
1322 48445-48455 Species denotes SARS-CoV-2 Tax:2697049
1323 48758-48768 Species denotes SARS-CoV-2 Tax:2697049
1329 48836-48841 Gene denotes spike Gene:43740568
1330 48843-48844 Gene denotes S Gene:43740568
1331 48879-48883 Gene denotes ACE2 Gene:59272
1332 48858-48859 Gene denotes S Gene:43740568
1333 48825-48835 Species denotes SARS-CoV-2 Tax:2697049
1344 48970-48971 Gene denotes S Gene:43740568
1345 48930-48931 Gene denotes S Gene:43740568
1346 48923-48929 Species denotes SARS-2 Tax:2697049
1347 48963-48969 Species denotes SARS-2 Tax:2697049
1348 49001-49007 Species denotes SARS-2 Tax:2697049
1349 49051-49057 Species denotes SARS-2 Tax:2697049
1350 49104-49110 Species denotes SARS-2 Tax:2697049
1351 49182-49208 Species denotes Shang et al., 2020b SARS-2 Tax:2697049
1352 49269-49275 Species denotes SARS-2 Tax:2697049
1353 49154-49175 CellLine denotes SARS-2 S319–529 44.2 CVCL:Z232
1355 49353-49357 Gene denotes ACE2 Gene:59272
1360 49442-49446 Gene denotes ACE2 Gene:59272
1361 49623-49627 Gene denotes ACE2 Gene:59272
1362 49512-49520 Species denotes SARS-CoV Tax:694009
1363 49636-49644 Species denotes SARS-CoV Tax:694009
1404 49886-49890 Gene denotes ACE2 Gene:59272
1405 50342-50346 Gene denotes ACE2 Gene:59272
1406 50407-50411 Gene denotes ACE2 Gene:59272
1407 50560-50564 Gene denotes ACE2 Gene:59272
1408 50582-50586 Gene denotes ACE2 Gene:59272
1409 50781-50785 Gene denotes ACE2 Gene:59272
1410 51223-51225 Gene denotes β5 Gene:28884
1411 51379-51383 Gene denotes ACE2 Gene:59272
1412 51579-51583 Gene denotes ACE2 Gene:59272
1413 51823-51827 Gene denotes ACE2 Gene:59272
1414 51909-51913 Gene denotes ACE2 Gene:59272
1415 52025-52029 Gene denotes ACE2 Gene:59272
1416 52192-52196 Gene denotes ACE2 Gene:59272
1417 52388-52392 Gene denotes ACE2 Gene:59272
1418 50707-50708 Gene denotes S Gene:43740568
1419 50434-50435 Gene denotes S Gene:43740568
1420 50308-50309 Gene denotes S Gene:43740568
1421 50203-50204 Gene denotes S Gene:43740568
1422 50906-50908 Gene denotes β6 Gene:28873
1423 50899-50901 Gene denotes β5 Gene:28884
1424 49815-49825 Species denotes SARS-CoV-2 Tax:2697049
1425 49891-49901 Species denotes SARS-CoV-2 Tax:2697049
1426 50565-50573 Species denotes SARS-CoV Tax:694009
1427 50587-50597 Species denotes SARS-CoV-2 Tax:2697049
1428 50662-50672 Species denotes SARS-CoV-2 Tax:2697049
1429 50732-50740 Species denotes SARS-CoV Tax:694009
1430 51333-51343 Species denotes SARS-CoV-2 Tax:2697049
1431 51348-51356 Species denotes SARS-CoV Tax:694009
1432 51385-51393 Species denotes SARS-CoV Tax:694009
1433 51472-51482 Species denotes SARS-CoV-2 Tax:2697049
1434 51664-51674 Species denotes SARS-CoV-2 Tax:2697049
1435 52041-52051 Species denotes SARS-CoV-2 Tax:2697049
1436 52177-52187 Species denotes SARS-CoV-2 Tax:2697049
1437 51415-51426 Chemical denotes Pro-Pro-Ala MESH:C027789
1438 51453-51468 Chemical denotes Gly-Val-Glu-Gly
1439 51600-51605 Chemical denotes Ser19
1440 51610-51615 Chemical denotes Gln24
1441 51654-51660 Chemical denotes Phe486
1442 51814-51819 Chemical denotes Tyr83
1443 51849-51855 Chemical denotes Asn501
1454 52456-52468 Gene denotes RBD-receptor
1455 52810-52814 Gene denotes ACE2 Gene:480847
1456 52986-52990 Gene denotes ACE2 Gene:59272
1457 52984-52985 Gene denotes S Gene:43740568
1458 52867-52868 Gene denotes S Gene:43740568
1459 52790-52794 Species denotes cats Tax:9685
1460 52799-52803 Species denotes dogs Tax:9615
1461 52856-52866 Species denotes SARS-CoV-2 Tax:2697049
1462 52891-52899 Disease denotes COVID-19 MESH:C000657245
1463 52900-52909 Disease denotes infection MESH:D007239
1484 53094-53098 Gene denotes ACE2 Gene:59272
1485 53383-53386 Gene denotes ACE Gene:1636
1486 53533-53537 Gene denotes ACE2 Gene:59272
1487 53723-53727 Gene denotes ACE2 Gene:59272
1488 53783-53787 Gene denotes ACE2 Gene:59272
1489 53837-53841 Gene denotes ACE2 Gene:59272
1490 53039-53044 Species denotes human Tax:9606
1491 53045-53048 Species denotes CoV Tax:11118
1492 53050-53059 Species denotes hCoV-NL63 Tax:277944
1493 53206-53216 Species denotes SARS-CoV-2 Tax:2697049
1494 53262-53271 Species denotes hCoV-NL63 Tax:277944
1495 53294-53302 Species denotes SARS-CoV Tax:694009
1496 53445-53455 Species denotes SARS-CoV-2 Tax:2697049
1497 53480-53484 Species denotes CoVs Tax:11118
1498 53622-53631 Species denotes novel CoV Tax:2697049
1499 53647-53653 Species denotes humans Tax:9606
1500 53713-53717 Species denotes CoVs Tax:11118
1501 53773-53776 Species denotes CoV Tax:11118
1502 53880-53890 Species denotes SARS-CoV-2 Tax:2697049
1503 53951-53954 Species denotes CoV Tax:11118
1505 54005-54009 Gene denotes ACE2 Gene:59272
1536 54078-54086 Species denotes patients Tax:9606
1537 54536-54544 Species denotes patients Tax:9606
1538 55204-55212 Species denotes patients Tax:9606
1539 55944-55952 Species denotes patients Tax:9606
1540 55983-55993 Species denotes SARS-CoV-2 Tax:2697049
1541 54069-54077 Disease denotes COVID-19 MESH:C000657245
1542 54194-54206 Disease denotes hypertension MESH:D006973
1543 54208-54231 Disease denotes cardiovascular diseases MESH:D002318
1544 54236-54260 Disease denotes type-2 diabetes mellitus MESH:D003924
1545 54527-54535 Disease denotes infected MESH:D007239
1546 54618-54630 Disease denotes hypertension MESH:D006973
1547 54640-54648 Disease denotes diabetes MESH:D003920
1548 54661-54684 Disease denotes cardiovascular diseases MESH:D002318
1549 54834-54846 Disease denotes hypertension MESH:D006973
1550 54856-54878 Disease denotes cardiovascular disease MESH:D002318
1551 55046-55054 Disease denotes COVID-19 MESH:C000657245
1552 55268-55280 Disease denotes hypertension MESH:D006973
1553 55285-55294 Disease denotes mortality MESH:D003643
1554 55382-55394 Disease denotes hypertension MESH:D006973
1555 55402-55410 Disease denotes diabetes MESH:D003920
1556 55422-55444 Disease denotes cardiovascular disease MESH:D002318
1557 55477-55485 Disease denotes Diabetes MESH:D003920
1558 55533-55537 Disease denotes ARDS MESH:D012128
1559 55551-55570 Disease denotes acute kidney injury MESH:D058186
1560 55584-55596 Disease denotes septic shock MESH:D012772
1561 55624-55633 Disease denotes mortality MESH:D003643
1562 55795-55804 Disease denotes mortality MESH:D003643
1563 55888-55896 Disease denotes COVID-19 MESH:C000657245
1564 55915-55922 Disease denotes obesity MESH:D009765
1565 56126-56135 Disease denotes mortality MESH:D003643
1571 56395-56399 Gene denotes ACE2 Gene:59272
1572 56556-56560 Gene denotes ACE2 Gene:59272
1573 56690-56700 Species denotes SARS-CoV-2 Tax:2697049
1574 56226-56238 Disease denotes hypertensive MESH:D006973
1575 56598-56616 Disease denotes SARS-CoV infection MESH:C000657245
1581 57665-57668 Gene denotes ACE Gene:1636
1582 56786-56796 Species denotes SARS-CoV-2 Tax:2697049
1583 57716-57724 Species denotes patients Tax:9606
1584 57735-57747 Disease denotes hypertension MESH:D006973
1585 57772-57793 Disease denotes coronavirus infection MESH:D018352
1595 58004-58008 Gene denotes ACE2 Gene:59272
1596 58063-58067 Gene denotes ACE2 Gene:59272
1597 58070-58074 Gene denotes ACE2 Gene:59272
1598 58221-58225 Gene denotes ACE2 Gene:59272
1599 58281-58291 Species denotes SARS-CoV-2 Tax:2697049
1600 57922-57937 Disease denotes viral infection MESH:D001102
1601 58158-58170 Disease denotes hypertension MESH:D006973
1602 58172-58194 Disease denotes cardiovascular disease MESH:D002318
1603 58199-58207 Disease denotes diabetes MESH:D003920
1611 58479-58483 Gene denotes ACE2 Gene:59272
1612 58650-58654 Gene denotes ACE2 Gene:59272
1613 58771-58775 Gene denotes ACE2 Gene:59272
1614 58500-58508 Gene denotes membrane Gene:43740571
1615 58525-58545 Disease denotes SARS-CoV-2 infection MESH:C000657245
1616 58706-58715 Disease denotes infection MESH:D007239
1617 58814-58834 Disease denotes respiratory distress MESH:D012128
1622 59181-59189 Species denotes patients Tax:9606
1623 59195-59203 Disease denotes COVID-19 MESH:C000657245
1624 59208-59220 Disease denotes hypertension MESH:D006973
1625 59309-59318 Disease denotes mortality MESH:D003643
1630 59582-59590 Species denotes patients Tax:9606
1631 59700-59708 Species denotes patients Tax:9606
1632 59596-59604 Disease denotes COVID-19 MESH:C000657245
1633 59714-59722 Disease denotes COVID-19 MESH:C000657245
1645 60004-60008 Gene denotes ACE2 Gene:59272
1646 60033-60037 Gene denotes ACE2 Gene:59272
1647 60166-60170 Gene denotes ACE2 Gene:59272
1648 60205-60209 Gene denotes SIT1 Gene:27240
1649 59961-59966 Species denotes human Tax:9606
1650 60095-60100 Species denotes human Tax:9606
1651 60101-60109 Species denotes patients Tax:9606
1652 60184-60192 Gene denotes membrane Gene:43740571
1653 59937-59957 Disease denotes SARS-CoV-2 infection MESH:C000657245
1654 60247-60255 Disease denotes COVID-19 MESH:C000657245
1655 60295-60307 Disease denotes hypertensive MESH:D006973
1657 60318-60322 Gene denotes ACE2 Gene:59272
1673 60633-60641 Species denotes patients Tax:9606
1674 61230-61238 Species denotes patients Tax:9606
1675 60399-60415 Disease denotes viral infections MESH:D001102
1676 60417-60424 Disease denotes COVID19 MESH:C000657245
1677 60552-60556 Disease denotes ARDS MESH:D012128
1678 60574-60585 Disease denotes lung injury MESH:D055370
1679 60688-60692 Disease denotes ARDS MESH:D012128
1680 60758-60766 Disease denotes COVID-19 MESH:C000657245
1681 60812-60821 Disease denotes pneumonia MESH:D011014
1682 60851-60871 Disease denotes microvascular damage MESH:D017566
1683 61020-61046 Disease denotes cardiovascular involvement MESH:D002318
1684 61090-61107 Disease denotes myocardial injury MESH:D009202
1685 61112-61124 Disease denotes sudden death MESH:D003645
1686 61154-61163 Disease denotes infection MESH:D007239
1687 61221-61229 Disease denotes COVID-19 MESH:C000657245
1703 61778-61783 Gene denotes IL-1β Gene:3552
1704 61785-61790 Gene denotes IFN-γ Gene:3458
1705 61792-61797 Gene denotes IP-10 Gene:3627
1706 61799-61804 Gene denotes MCP-1 Gene:6347
1707 61806-61810 Gene denotes IL-4 Gene:3565
1708 61816-61821 Gene denotes IL-10 Gene:3586
1709 61530-61538 Species denotes patients Tax:9606
1710 61644-61652 Species denotes patients Tax:9606
1711 61730-61738 Species denotes patients Tax:9606
1712 61842-61848 Species denotes people Tax:9606
1713 61864-61872 Species denotes patients Tax:9606
1714 61475-61484 Disease denotes infection MESH:D007239
1715 61601-61609 Disease denotes COVID-19 MESH:C000657245
1716 61614-61623 Disease denotes pneumonia MESH:D011014
1717 61653-61657 Disease denotes ARDS MESH:D012128
1725 62238-62242 Gene denotes ACE2 Gene:59272
1726 62326-62330 Gene denotes ACE2 Gene:59272
1727 63174-63179 Gene denotes NLRP3 Gene:114548
1728 63342-63351 Gene denotes caspase 1 Gene:834
1729 63116-63124 Gene denotes membrane Gene:43740571
1730 62720-62732 Disease denotes inflammation MESH:D007249
1731 63460-63472 Disease denotes inflammation MESH:D007249
1734 63599-63603 Gene denotes ACE2 Gene:59272
1735 63668-63678 Species denotes SARS-CoV-2 Tax:2697049
1746 63804-63809 Gene denotes NLRP3 Gene:114548
1747 63875-63880 Gene denotes IL-1β Gene:3552
1748 64010-64015 Gene denotes IL-1β Gene:3552
1749 63914-63922 Species denotes patients Tax:9606
1750 63687-63707 Disease denotes SARS-CoV-2 infection MESH:C000657245
1751 63905-63913 Disease denotes COVID-19 MESH:C000657245
1752 64062-64073 Disease denotes leucopoenia
1753 64078-64089 Disease denotes lymphopenia MESH:D008231
1754 64110-64128 Disease denotes COVID-19 pneumonia MESH:C000657245
1755 64183-64214 Disease denotes lymphocyte injury by pyroptosis MESH:D015451
1771 64316-64319 Gene denotes ACE Gene:1636
1772 64320-64324 Gene denotes ACE2 Gene:59272
1773 64388-64392 Gene denotes ACE2 Gene:59272
1774 64663-64667 Gene denotes AT1R Gene:185
1775 64721-64728 Gene denotes ADAM 17 Gene:6868
1776 64744-64748 Gene denotes TNFα Gene:7124
1777 64765-64769 Gene denotes TACE Gene:6868
1778 64851-64855 Gene denotes EGFR Gene:1956
1779 64861-64865 Gene denotes TNFα Gene:7124
1780 65011-65018 Gene denotes ADAM 17 Gene:6868
1781 65076-65082 Gene denotes IL-6Rα Gene:3570
1782 65094-65098 Gene denotes IL-6 Gene:3569
1783 65099-65104 Gene denotes STAT3 Gene:6774
1784 65413-65428 Gene denotes angiotensinogen Gene:183
1785 64302-64312 Species denotes SARS-CoV-2 Tax:2697049
1803 65531-65535 Gene denotes ACE2 Gene:59272
1804 65620-65624 Gene denotes ACE2 Gene:59272
1805 65750-65754 Gene denotes ACE2 Gene:59272
1806 65874-65881 Gene denotes ADAM 17 Gene:6868
1807 65924-65928 Gene denotes TNFα Gene:7124
1808 65988-65992 Gene denotes ACE2 Gene:59272
1809 66166-66170 Gene denotes ACE2 Gene:59272
1810 66401-66405 Gene denotes ACE2 Gene:59272
1811 66474-66480 Gene denotes ADAM17 Gene:6868
1812 66111-66116 Species denotes human Tax:9606
1813 66160-66165 Species denotes human Tax:9606
1814 65951-65959 Gene denotes membrane Gene:43740571
1815 66200-66225 Chemical denotes phorbol myristate acetate MESH:D013755
1816 65588-65600 Disease denotes inflammation MESH:D007249
1817 66117-66133 Disease denotes embryonic kidney MESH:D007674
1818 66141-66147 CellLine denotes HEK293 CVCL:0045
1819 66172-66180 CellLine denotes HEK-ACE2 CVCL:L310
1829 66628-66632 Gene denotes ACE2 Gene:59272
1830 66774-66778 Gene denotes ACE2 Gene:59272
1831 66916-66921 Gene denotes IL-1β Gene:3552
1832 66977-66981 Gene denotes ACE2 Gene:59272
1833 67144-67148 Gene denotes ACE2 Gene:59272
1834 67226-67232 Gene denotes ADAM17 Gene:6868
1835 67297-67307 Species denotes SARS-CoV-2 Tax:2697049
1836 66705-66720 Disease denotes viral infection MESH:D001102
1837 67188-67203 Disease denotes viral infection MESH:D001102
1849 67465-67475 Species denotes SARS-CoV-2 Tax:2697049
1850 67853-67863 Species denotes SARS-CoV-2 Tax:2697049
1851 67896-67906 Species denotes SARS-CoV-2 Tax:2697049
1852 68269-68279 Species denotes SARS-CoV-2 Tax:2697049
1853 67491-67500 Chemical denotes vitamin D MESH:D014807
1854 67625-67640 Disease denotes hypovitaminosis
1855 67668-67676 Disease denotes COVID-19 MESH:C000657245
1856 67988-68003 Disease denotes hypovitaminosis
1857 68010-68030 Disease denotes pulmonary infections MESH:D012141
1858 68087-68109 Disease denotes respiratory infections MESH:D012141
1859 68294-68303 Disease denotes mortality MESH:D003643
1861 68370-68374 Gene denotes ACE2 Gene:59272
1868 68422-68426 Gene denotes ACE2 Gene:59272
1869 68599-68603 Gene denotes ACE2 Gene:59272
1870 68528-68538 Species denotes SARS-CoV-2 Tax:2697049
1871 68468-68476 Disease denotes COVID-19 MESH:C000657245
1872 68613-68622 Disease denotes infection MESH:D007239
1873 68780-68791 Disease denotes lung injury MESH:D055370
1880 68934-68938 Gene denotes ACE2 Gene:59272
1881 69013-69018 Gene denotes ACE 2 Gene:59272
1882 69074-69078 Gene denotes ACE2 Gene:59272
1883 69120-69129 Gene denotes S-protein Gene:43740568
1884 69007-69012 Species denotes human Tax:9606
1885 68948-68957 Disease denotes infection MESH:D007239
1887 69168-69172 Gene denotes ACE2 Gene:59272
1889 69215-69219 Gene denotes ACE2 Gene:59272
1891 69222-69226 Gene denotes ACE2 Gene:59272
1907 69248-69252 Gene denotes ACE2 Gene:59272
1908 69772-69776 Gene denotes ACE2 Gene:59272
1909 70024-70028 Gene denotes ACE2 Gene:59272
1910 70130-70134 Gene denotes ACE2 Gene:59272
1911 70240-70244 Gene denotes ACE2 Gene:59272
1912 70429-70433 Gene denotes ACE2 Gene:59272
1913 69633-69641 Species denotes SARS-CoV Tax:694009
1914 69855-69863 Species denotes SARS-CoV Tax:694009
1915 70313-70329 Species denotes SARS coronavirus Tax:694009
1916 70065-70074 Gene denotes S-protein Gene:43740568
1917 69720-69758 Chemical denotes N-(2-aminoethyl)-1aziridine-ethanamine
1918 69760-69764 Chemical denotes NAAE
1919 70091-70095 Chemical denotes NAAE
1920 70276-70293 Disease denotes acute lung injury MESH:D055371
1921 70297-70307 Disease denotes infections MESH:D007239
1932 70590-70594 Gene denotes ACE2 Gene:59272
1933 70654-70658 Gene denotes ACE2 Gene:59272
1934 70805-70809 Gene denotes ACE2 Gene:59272
1935 71031-71062 Gene denotes angiotensin-converting enzyme 2 Gene:59272
1936 70708-70718 Species denotes SARS-CoV-2 Tax:2697049
1937 71025-71030 Species denotes human Tax:9606
1938 71075-71083 Species denotes patients Tax:9606
1939 71064-71070 Chemical denotes rhACE2
1940 70903-70914 Disease denotes lung injury MESH:D055370
1941 71089-71097 Disease denotes COVID-19 MESH:C000657245
1959 71141-71146 Gene denotes ACE 2 Gene:59272
1960 71241-71250 Gene denotes S-protein Gene:43740568
1961 71943-71948 Gene denotes hACE2 Gene:59272
1962 72096-72100 Gene denotes ACE2 Gene:59272
1963 72210-72214 Gene denotes ACE2 Gene:59272
1964 71135-71140 Species denotes human Tax:9606
1965 71404-71412 Species denotes patients Tax:9606
1966 71644-71652 Species denotes patients Tax:9606
1967 71811-71816 Species denotes human Tax:9606
1968 71844-71849 Species denotes human Tax:9606
1969 72005-72015 Species denotes SARS-CoV-2 Tax:2697049
1970 72112-72122 Species denotes SARS-CoV-2 Tax:2697049
1971 71538-71544 Chemical denotes rhACE2
1972 71724-71730 Chemical denotes rhACE2
1973 71395-71403 Disease denotes COVID-19 MESH:C000657245
1974 71658-71662 Disease denotes ARDS MESH:D012128
1975 71775-71796 Disease denotes SARS-CoV-2 infections MESH:C000657245
1979 72294-72298 Gene denotes ACE2 Gene:59272
1980 72641-72645 Gene denotes ACE2 Gene:59272
1981 72597-72612 Disease denotes viral infection MESH:D001102
1983 72724-72728 Gene denotes ACE2 Gene:59272
1992 72748-72752 Gene denotes ACE2 Gene:59272
1993 72844-72848 Gene denotes ACE2 Gene:59272
1994 72886-72896 Gene denotes collectrin Gene:57393
1995 72955-72962 Gene denotes insulin Gene:3630
1996 73009-73013 Gene denotes ACE2 Gene:59272
1997 73115-73119 Gene denotes ACE2 Gene:59272
1998 73184-73198 Species denotes gut microbiome Tax:749906
1999 73040-73057 Disease denotes Hartnup’s disease MESH:D006250
2007 73235-73239 Gene denotes ACE2 Gene:59272
2008 73358-73362 Gene denotes ACE2 Gene:59272
2009 73363-73367 Gene denotes Ang1 Gene:284
2010 73392-73399 Gene denotes insulin Gene:3630
2011 73479-73483 Gene denotes ACE2 Gene:59272
2012 73370-73374 Gene denotes MasR Gene:116511
2013 73302-73321 Disease denotes glucose homeostasis MESH:D044882
2017 73629-73633 Gene denotes ACE2 Gene:59272
2018 73697-73701 Gene denotes ACE2 Gene:59272
2019 73649-73666 Disease denotes Alzheimer disease MESH:D000544
2038 73848-73852 Gene denotes ACE2 Gene:59272
2039 74136-74140 Gene denotes ACE2 Gene:59272
2040 74203-74207 Gene denotes ACE2 Gene:59272
2041 74318-74322 Gene denotes ACE2 Gene:70008
2042 74489-74493 Gene denotes ACE2 Gene:70008
2043 74521-74531 Gene denotes E-cadherin Gene:999
2044 74575-74583 Gene denotes vimentin Gene:7431
2045 74105-74113 Species denotes patients Tax:9606
2046 74270-74275 Species denotes human Tax:9606
2047 74290-74294 Species denotes mice Tax:10090
2048 73840-73846 Disease denotes cancer MESH:D009369
2049 73874-73880 Disease denotes cancer MESH:D009369
2051 74080-74104 Disease denotes hepatocellular carcinoma MESH:D006528
2052 74333-74338 Disease denotes tumor MESH:D009369
2053 74390-74416 Disease denotes Non-Small Cell Lung Cancer MESH:D002289
2054 74418-74423 Disease denotes NSCLC MESH:D002289
2055 74647-74652 Disease denotes NSCLC MESH:D002289
2062 74890-74894 Gene denotes ACE2 Gene:59272
2063 74731-74739 Species denotes patients Tax:9606
2064 74719-74730 Disease denotes lung cancer MESH:D008175
2065 74752-74760 Disease denotes COVID-19 MESH:C000657245
2066 74873-74885 Disease denotes malignancies MESH:D009369
2067 74982-74988 Disease denotes cancer MESH:D009369
2071 75060-75064 Gene denotes ACE2 Gene:59272
2072 75147-75151 Gene denotes ACE2 Gene:59272
2073 75086-75092 Disease denotes cancer MESH:D009369
2084 75205-75209 Gene denotes ACE2 Gene:59272
2085 75472-75476 Gene denotes ACE2 Gene:59272
2086 75247-75253 Disease denotes tumors MESH:D009369
2087 75255-75275 Disease denotes colon adenocarcinoma MESH:D003110
2088 75284-75321 Disease denotes kidney renal papillary cell carcinoma MESH:C538614
2089 75330-75355 Disease denotes pancreatic adenocarcinoma MESH:D000230
2090 75364-75385 Disease denotes rectum adenocarcinoma MESH:D012004
2091 75394-75416 Disease denotes stomach adenocarcinoma MESH:D000230
2092 75429-75448 Disease denotes lung adenocarcinoma MESH:D000077192
2093 75508-75536 Disease denotes lung squamous cell carcinoma MESH:D002294
2099 75550-75554 Gene denotes ACE2 Gene:59272
2100 75596-75602 Disease denotes tumors MESH:D009369
2101 75633-75650 Disease denotes thyroid carcinoma MESH:D013964
2102 75663-75681 Disease denotes kidney chromophobe MESH:D000238
2103 75683-75687 Disease denotes KICH
2106 75706-75710 Gene denotes ACE2 Gene:59272
2107 75791-75795 Gene denotes ACE2 Gene:59272
2110 75877-75881 Gene denotes ACE2 Gene:59272
2111 75936-75940 Gene denotes ACE2 Gene:59272
2114 76109-76113 Gene denotes ACE2 Gene:59272
2115 76128-76135 Species denotes patient Tax:9606
2122 76243-76247 Gene denotes ACE2 Gene:59272
2123 76428-76432 Gene denotes ACE2 Gene:59272
2124 76566-76570 Gene denotes ACE2 Gene:59272
2125 76339-76347 Chemical denotes Oncomine
2126 76411-76416 Disease denotes tumor MESH:D009369
2127 76531-76552 Disease denotes endometrial carcinoma MESH:D016889
2135 76683-76687 Gene denotes ACE2 Gene:59272
2136 76710-76713 Gene denotes ACE Gene:1636
2137 76753-76756 Gene denotes ACE Gene:1636
2138 76906-76910 Gene denotes ACE2 Gene:59272
2139 77070-77073 Gene denotes ACE Gene:1636
2140 77164-77168 Gene denotes ACE2 Gene:59272
2141 77010-77036 Disease denotes cardiovascular homeostasis MESH:D002318
2154 77376-77380 Gene denotes ACE2 Gene:59272
2155 77631-77635 Gene denotes ACE2 Gene:59272
2156 77784-77788 Gene denotes ACE2 Gene:59272
2157 77817-77821 Gene denotes ACE2 Gene:59272
2158 77981-77985 Gene denotes ACE2 Gene:59272
2159 78143-78147 Gene denotes ACE2 Gene:59272
2160 77457-77465 Species denotes SARS-Cov Tax:694009
2161 77470-77479 Species denotes SARS-Cov2 Tax:2697049
2162 77689-77702 Species denotes coronaviruses Tax:11118
2163 77350-77358 Disease denotes COVID-19 MESH:C000657245
2164 77907-77915 Disease denotes COVID-19 MESH:C000657245
2165 78152-78160 Disease denotes COVID-19 MESH:C000657245
2167 78312-78314 Disease denotes FS MESH:D018223

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-30 Sentence denotes ACE2 in the Era of SARS-CoV-2:
T2 31-67 Sentence denotes Controversies and Novel Perspectives
T3 69-77 Sentence denotes Abstract
T4 78-206 Sentence denotes Angiotensin-converting enzyme 2 (ACE2) is related to ACE but turned out to counteract several pathophysiological actions of ACE.
T5 207-295 Sentence denotes ACE2 exerts antihypertensive and cardioprotective effects and reduces lung inflammation.
T6 296-418 Sentence denotes ACE2 is subjected to extensive transcriptional and post-transcriptional modulation by epigenetic mechanisms and microRNAs.
T7 419-548 Sentence denotes Also, ACE2 expression is regulated post-translationally by glycosylation, phosphorylation, and shedding from the plasma membrane.
T8 549-666 Sentence denotes ACE2 protein is ubiquitous across mammalian tissues, prominently in the cardiovascular system, kidney, and intestine.
T9 667-955 Sentence denotes ACE2 expression in the respiratory tract is of particular interest, in light of the discovery that ACE2 serves as the initial cellular target of severe acute respiratory syndrome (SARS)-coronaviruses, including the recent SARS-CoV2, responsible of the COronaVIrus Disease 2019 (COVID-19).
T10 956-1102 Sentence denotes Since the onset of the COVID-19 pandemic, an intense effort has been made to elucidate the biochemical determinants of SARS-CoV2-ACE2 interaction.
T11 1103-1377 Sentence denotes It has been determined that SARS-CoV2 engages with ACE2 through its spike (S) protein, which consists of two subunits: S1, that mediates binding to the host receptor; S2, that induces fusion of the viral envelope with the host cell membrane and delivery of the viral genome.
T12 1378-1647 Sentence denotes Owing to the role of ACE2 in SARS-CoV2 pathogenicity, it has been speculated that medical conditions, i.e., hypertension, and/or drugs, i.e., ACE inhibitors and angiotensin receptor blockers, known to influence ACE2 density could alter the fate of SARS-CoV-2 infection.
T13 1648-1792 Sentence denotes The debate is still open and will only be solved when results of properly designed experimental and clinical investigations will be made public.
T14 1793-1919 Sentence denotes An interesting observation is, however that, upon infection, ACE2 activity is reduced either by downregulation or by shedding.
T15 1920-2032 Sentence denotes These events might precipitate the so-called “cytokine storm” that characterizes the most severe COVID-19 forms.
T16 2033-2142 Sentence denotes As evidence accumulates, ACE2 appears a druggable target in the attempt to limit virus entry and replication.
T17 2143-2346 Sentence denotes Strategies aimed at blocking ACE2 with antibodies, small molecules or peptides, or at neutralizing the virus by competitive binding with exogenously administered ACE2, are currently under investigations.
T18 2347-2577 Sentence denotes In this review, we will present an overview of the state-of-the-art knowledge on ACE2 biochemistry and pathophysiology, outlining open issues in the context of COVID-19 disease and potential experimental and clinical developments.
T19 2579-2591 Sentence denotes Introduction
T20 2592-2770 Sentence denotes Angiotensin-converting enzyme (ACE) has an important role in the metabolism of several peptides and proteins, including chemical messengers, such as angiotensin I and bradykinin.
T21 2771-3044 Sentence denotes The importance assumed by research focused on ACE biochemistry, physiology and pharmacology is closely linked to the clinical effectiveness showed by ACE inhibitors in the treatment of cardiovascular disease, particularly arterial hypertension and congestive heart failure.
T22 3045-3125 Sentence denotes At present, ACE inhibitors are among the most widely prescribed drugs worldwide.
T23 3126-3197 Sentence denotes In 2000 a novel ACE-like enzyme, eventually named ACE2, was discovered.
T24 3198-3297 Sentence denotes It showed a different substrate selectively, and in particular it could not activate angiotensin I.
T25 3298-3364 Sentence denotes At the same time, it was not a target of classical ACE inhibitors.
T26 3365-3564 Sentence denotes Investigations were therefore started, aiming at determining the role of ACE2, and the general hypothesis that ACE2 may counteract several physiological consequences of ACE activation was introduced.
T27 3565-3737 Sentence denotes In 2003 ACE2 was also identified as the initial cellular target of the SARS-CoV virus, since its spike glycoprotein was found to be a high affinity ligand of membrane ACE2.
T28 3738-3952 Sentence denotes Similar properties are shared by SARS-CoV-2 virus, and the huge impact of the recent COVID-19 pandemic has triggered novel interest in ACE2, particularly in the regulation of its expression in different cell types.
T29 3953-4194 Sentence denotes Hypertension has been suggested to have a major impact on COVID-19 susceptibility and prognosis, therefore the elusive link between hypertension, anti-hypertensive drugs, and ACE2 expression has soon become the object of a major controversy.
T30 4195-4374 Sentence denotes On the other hand, treatments able to interfere with ACE2 expression, or ACE2 availability for SARS-CoV-2 binding, have been identified as a novel goal of pharmaceutical research.
T31 4375-4482 Sentence denotes The purpose of the present review is to summarize the available knowledge on ACE2 biochemistry and biology.
T32 4483-4653 Sentence denotes We have also tried to point out some crucial open questions, which should be addressed to provide a better background for future experimental and clinical investigations.
T33 4655-4684 Sentence denotes ACE System and ACE2 Discovery
T34 4685-4908 Sentence denotes Human Angiotensin-converting enzyme (ACE) belongs to the M2 gluzincin family of metalloproteinases and (Ehlers and Riordan, 1989; Masuyer et al., 2014) exists in two forms, namely somatic ACE (sACE) and germinal ACE (tACE).
T35 4909-5131 Sentence denotes Both are derived from the same gene, controlled by alternative promotors. sACE is an integral membrane protein, which can be also cleaved by ACE secretases to produce a circulating form of the enzyme (Natesh et al., 2003).
T36 5132-5368 Sentence denotes sACE, hereafter referred to simply as ACE, has been extensively studied, because of its crucial role in the homeostasis of renin-angiotensin-aldosterone (RAAS) system and in cardiovascular diseases (Takimoto-Ohnishi and Murakami, 2019).
T37 5369-5602 Sentence denotes The two extracellular domains N and C domains of ACE (Wei et al., 1991; Jaspard et al., 1993; Natesh et al., 2003; Riordan, 2003) can both hydrolase two crucial peptides, namely angiotensin I and bradykinin, with the same efficiency.
T38 5603-5823 Sentence denotes Indeed, ACE carries out the cleavage of two amino acids (dipeptidase action) from the C-terminal part of angiotensin I to generate angiotensin II, which exerts a potent vasopressor, proliferative, and profibrotic effect.
T39 5824-5935 Sentence denotes Moreover, ACE mediates the cleavage and inactivation of bradykinin, which is a vasodilator hypotensive peptide.
T40 5936-6063 Sentence denotes The pivotal role of ACE in the RAAS system allows a refined blood pressure control and salt homeostasis (Sayer and Bhat, 2014).
T41 6064-6252 Sentence denotes Following the ACE discovery in mid-1950s, despite intense research in the field, no human homologs of the enzyme have been found for more than 50 years (Isaac et al., 1998; Riordan, 2003).
T42 6253-6404 Sentence denotes It was only in 2000 that two independent research groups identified, almost simultaneously, a new human ACE-like enzyme, with two different approaches.
T43 6405-6584 Sentence denotes Tipnis et al. (2000) searched for new metalloproteases in an expressed sequence tag (EST) database, finding an ACE homolog (ACEH) with a single domain, similar to that of insects.
T44 6585-6648 Sentence denotes Subsequently they cloned it from a human lymphoma cDNA library.
T45 6649-6837 Sentence denotes Interestingly ACEH showed high homology (40% identity and 60% similarity) with ACE, particularly around the HEXXH sequence and highly conserved glutamate residue, involved in zinc binding.
T46 6838-6930 Sentence denotes Moreover, they demonstrated the presence of seven glycosylation sites (Tipnis et al., 2000).
T47 6931-7251 Sentence denotes In the same year, Donoghue et al. (2000b) were searching for new genes involved in heart failure and identified a human cDNA ACE homolog, named ACE2, among 19,000 5’end sequences by RACE (rapid amplification of cDNA ends) in the heart ventricle cDNA library, obtained from a woman with idiopathic dilated cardiomyopathy.
T48 7252-7354 Sentence denotes ACE2 showed a transmembrane domain, a zinc catalytic domain 42% identical to ACE and a signal peptide.
T49 7355-7412 Sentence denotes Like ACE, ACE2 seemed to be an ectoenzyme type I protein.
T50 7413-7581 Sentence denotes The authors identified ACE2 transcripts quite exclusively in the heart and in the kidney, suggesting a role for ACE2 in the local RAAS control (Donoghue et al., 2000b).
T51 7582-7721 Sentence denotes In the following years, ACE2 was intensively studied, its structure and function were enlightened, and tentative inhibitors were developed.
T52 7723-7728 Sentence denotes ACE2:
T53 7729-7785 Sentence denotes Structure, Expression, Tissue Distribution, and Function
T54 7787-7804 Sentence denotes Structure of ACE2
T55 7805-7926 Sentence denotes ACE2 is a 40 kb gene and it is positioned on chromosome Xp22, differently from ACE gene that is located on chromosome 17.
T56 7927-7984 Sentence denotes The 18 exons of ACE2 are remarkably similar to ACE exons.
T57 7985-8274 Sentence denotes The ACE2 gene depicts a large polymorphism and several novel polymorphisms of ACE2, with specific geographical distribution, have been described and associated with susceptibility to hypertension and cardiovascular disease (Burrell et al., 2013; Patel et al., 2014; Pinheiro et al., 2019).
T58 8275-8395 Sentence denotes The ACE2 gene codifies for a typical zinc-metallopeptidase of 805 amino acids (120 kDa), with a unique catalytic domain.
T59 8396-8506 Sentence denotes Despite the high resemblance of ACE and ACE2, considerable differences exist in their substrates and products.
T60 8507-8596 Sentence denotes While ACE acts as dipeptidase, ACE2 removes only a single amino acid from its substrates.
T61 8597-8848 Sentence denotes Therefore, ACE2 is not active in transforming angiotensin I to angiotensin II and in inactivating bradykinin; moreover, ACE2 is insensitive to ACE inhibitors, like lisinopril and captopril (Tipnis et al., 2000; Rice et al., 2004; Turner et al., 2004).
T62 8849-8946 Sentence denotes These differences depend on variances in the three-dimensional structure (3D) of the two enzymes.
T63 8947-9055 Sentence denotes Comparative homology modeling and crystallography contributed to shed light on ACE2 3D structure (Figure 1).
T64 9056-9208 Sentence denotes Prabakaran et al. (2004) clarified the major characteristic of ACE2, which is a deep channel on the summit of the protein, hosting the catalytic domain.
T65 9209-9357 Sentence denotes Specific loops, like the long loop N210-Q221 that is exclusive of ACE2, α helices and a portion of β-sheet are located around the catalytic channel.
T66 9358-9518 Sentence denotes The negative charge of the channel and the presence of distinct hydrophobic regions contribute to the specificity of the binding site (Prabakaran et al., 2004).
T67 9519-9781 Sentence denotes The determination of the crystal structure of the extracellular domain to 2.2-3-A resolution from Towler et al. (2004) and the model from Guy et al. (2003) showed that the catalytic domain of ACE and ACE2 are very conserved and have similar mechanisms of action.
T68 9782-10053 Sentence denotes The main difference stems from the smaller ACE2 pocket, thereby lodging only a single amino acid: the crucial substitution of the Gln281 in ACE binding pocket with Arg273 in ACE2 is likely to be responsible for the steric conflict (Guy et al., 2003; Towler et al., 2004).
T69 10054-10290 Sentence denotes Another surprise of the ACE2 structure was its C-terminal domain, which—differently from ACE—revealed high homology with collectrin, a renal protein, which is involved in amino acids trafficking through the membrane (Yang et al., 2017).
T70 10291-10327 Sentence denotes FIGURE 1 Crystal structure of ACE2.
T71 10328-10443 Sentence denotes The peptidase domain (PD) is in green, whereas the collectrin homology domain is enclosed in the light cyan square.
T72 10444-10589 Sentence denotes The active zinc ion is showed enclosed in a red circle, whereas the glycosylation moieties are showed as cyan cubes and denoted by dashed arrows.
T73 10590-10683 Sentence denotes The structures have been drawn from PDB 1R42 (Towler et al., 2004) by Mol on the PDB website.
T74 10685-10765 Sentence denotes Transcriptional, Post-transcriptional, and Post-translational Regulation of ACE2
T75 10766-11049 Sentence denotes The location of the ACE2 gene on the X chromosome questions whether one of the two ACE2 is silenced in females, to balance female/male expression dosage (X chromosome inactivation or XCI), or otherwise belongs to the class of “escape genes” which are transcribed on both chromosomes.
T76 11050-11238 Sentence denotes Interestingly, a wide survey of XCI in several individuals and tissues showed that ACE2 is a heterogeneous escape gene, because it has a tissue-dependent sex bias (Tukiainen et al., 2017).
T77 11239-11391 Sentence denotes A growing number of recent findings point to an important role of epigenetic mechanisms associated with several human diseases (Surguchov et al., 2017).
T78 11392-11566 Sentence denotes In this context, several authors highlighted the regulatory role of 17β-estradiol (E2), a primary female sex steroid, in the expression of ACE2 in a tissue-dependent fashion.
T79 11567-11715 Sentence denotes Liu et al. (2010) and Stelzig et al. (2020) found out that E2 downregulates ACE2 in kidney and differentiated airway epithelial cells, respectively.
T80 11716-11998 Sentence denotes The latter result is particularly important, as the male-bias of ACE2 expression in the lung could account for the alleged higher susceptibility of males to COVID-19 symptoms following ACE2-dependent SARS-CoV-2 infection (section Links Between ACE2 and COVID-19) (Jin et al., 2020).
T81 11999-12171 Sentence denotes Yet, Bukowska et al. (2017) observed that E2 increases ACE2 transcription and expression in human atrial tissue, while at the same time depressing the level of ACE protein.
T82 12172-12383 Sentence denotes This mechanism attenuates the renin-angiotensin system and, in tandem with anti-inflammatory and anti-oxidative effects, enables a stronger response to myocardial stress and contributes to antiarhythmic effects.
T83 12384-12530 Sentence denotes The upregulation of ACE2 (and downregulation of ACE) was clearly linked to binding of E2 to Estrogen Receptor alpha (ERα) (Bukowska et al., 2017).
T84 12531-12771 Sentence denotes The E2-ERα complex might migrate to the nucleus to bind to estrogen response elements, although the actual mechanism is still obscure and should likely involve other co-factors to take into account the observed tissue bias of E2 regulation.
T85 12772-13021 Sentence denotes Nonetheless, it was demonstrated that the Estrogen Related Receptor alpha (ERRα), which likewise ERα recognizes the estrogen response element in target genes, binds to ACE2 promoter to repress transcription (Tremblay et al., 2010; Lee et al., 2012).
T86 13022-13124 Sentence denotes Hopefully, future studies will shed more light on the intriguing role of estrogens in ACE2 regulation.
T87 13125-13287 Sentence denotes A recent analysis of public genomic and transcriptomic data outlined the role of histone methylation, a classical epigenetic mark, to regulate ACE2 transcription.
T88 13288-13449 Sentence denotes Indeed, Li Y. et al. (2020) showed that transcription of ACE2 was significantly upregulated when the histone mutant H3K27M was overexpressed to inhibit H3K27me3.
T89 13450-13532 Sentence denotes Conversely, overexpression of mutant H3K4/9/36M did not change ACE2 transcription.
T90 13533-13688 Sentence denotes Trimethylation of K27 on H3 is catalyzed by the polycomb groups (PcG), a group of conserved transcriptional gene repressors (Schuettengruber et al., 2017).
T91 13689-13751 Sentence denotes PcG proteins assemble into two major complexes: PRC1 and PRC2.
T92 13752-13876 Sentence denotes The simplest model of PcG activity involves trimethylation of H3 by PRC2 at target gene promoters (Blackledge et al., 2015).
T93 13877-14125 Sentence denotes These epigenetic marks recruit PRC1 on DNA, which in turn acts as E3-ligase and ubiquitinates nearby H2A histones (Storti et al., 2019), triggering silencing of gene transcription by local and reversible compaction of chromatin (Illingworth, 2019).
T94 14126-14191 Sentence denotes The catalytic subunit of PRC2 is constituted by the EZH2 protein.
T95 14192-14359 Sentence denotes In agreement with the inverse correlation between ACE2 level and H3K27me3, ACE2 expression in human ESCs was upregulated following EZH2 knock-out (Li Y. et al., 2020).
T96 14360-14423 Sentence denotes On the other side, recovery of EZH2 restored basal ACE2 levels.
T97 14424-14617 Sentence denotes Chromatin immunoprecipitation sequencing (ChIP-seq) showed that EZH2 depletion induced H3K27me3 decrease, with concomitant H3K27ac increase, at ACE2 promoter in human ESCs (Li Y. et al., 2020).
T98 14618-14904 Sentence denotes The role of H3 methylation and acetylation in the epigenetic regulation of ACE2 was also hypothesized by Pinto et al., who demonstrated that co-morbidities such as hypertension, diabetes, and chronic obstructive lung disease increase ACE2 transcription in the lung (Pinto et al., 2020).
T99 14905-14986 Sentence denotes Histone methylation does not appear to exhaust the epigenetic regulation of ACE2.
T100 14987-15135 Sentence denotes Notably, the NAD+-dependent deacetylase SIRT1 binds to ACE2 promoter favoring its transcription during cellular energy stress (Clarke et al., 2014).
T101 15136-15216 Sentence denotes Two recent unrefereed preprints highlighted other epigenetic mechanisms at play.
T102 15217-15421 Sentence denotes Corley et al.1 pointed out that DNA methylation across three CpG islands in the ACE2 promoter was lower in lung epithelial cells compared to other cell types, suggesting high transcription in lung tissue.
T103 15422-15624 Sentence denotes These findings are in excellent agreement with the reported inverse correlation between ACE2 transcription and promoter methylation in tumors, which will be discussed in section ACE2 and Other Diseases.
T104 15625-15807 Sentence denotes This correlation is also supported by the observation that in children ACE2 is normally hypermethylated and poorly expressed either in the lung and in other organs (Pruimboom, 2020).
T105 15808-16029 Sentence denotes Glinsky (2020) addressed the epigenetic role of Vitamin D on ACE2 expression, showing by gene set enrichment analysis that the Vitamin D receptor (VDR) should be involved in a set of regulatory pathways conveying on ACE2.
T106 16030-16239 Sentence denotes More specifically, VDR activation would downregulate ACE2, thus affording a potential reason for the alleged beneficial role of Vitamin D in COVID-19 (section ACE2 and the Inflammatory Response to Sars-CoV-2).
T107 16240-16359 Sentence denotes Finally, the strict homeostatic balance of ACE/ACE2 activities suggests transcriptional co-regulation of both proteins.
T108 16360-16655 Sentence denotes Remarkably, Yang et al. (2016) have demonstrated that a subtle regulatory mechanism acts in cardiac endothelial cells, where the Brg1 chromatin remodeler and the FoxM1 transcription factor cooperate to determine the ACE2/ACE expression ratio, particularly under cardiac hypertrophy of the heart.
T109 16656-16700 Sentence denotes Further regulation occurs at the mRNA level.
T110 16701-16826 Sentence denotes From putative microRNA-binding sites identified in vitro, Lambert et al. (2014) demonstrated that miR-421 downregulates ACE2.
T111 16827-16974 Sentence denotes According to the hypothesized mechanism, miR-421 modulates ACE2 expression by hampering translation rather than by degradation of mRNA transcripts.
T112 16975-17190 Sentence denotes Beside undergoing post-translational modifications by glycosylation and phosphorylation, ACE2 is also post-translationally regulated by shedding from cell membrane through the action of the metalloproteinase ADAM17.
T113 17191-17361 Sentence denotes The proteolysis of ACE2 releases a soluble, enzymatically active form which corresponds to the ACE2 ectodomain (Jia et al., 2009; Xiao et al., 2014; Conrad et al., 2016).
T114 17362-17479 Sentence denotes The function, if any, of soluble ACE2 is still obscure, but the shedding mechanism is under strict molecular control.
T115 17480-17642 Sentence denotes Lambert et al. (2008) highlighted that calmodulin associates with ACE2 to prevent its shedding, while calmodulin inhibitors increase the cellular release of ACE2.
T116 17643-17692 Sentence denotes Patel identified a positive feedback in the RAAS:
T117 17693-17803 Sentence denotes Ang II activates ADAM17, thereby increasing the release of ACE2, its negative regulator (Patel et al., 2016b).
T118 17804-17935 Sentence denotes It is worth noting that high levels of plasma-soluble ACE2 have been associated with myocardial dysfunction (Epelman et al., 2009).
T119 17936-18067 Sentence denotes The potential pathophysiological role of ADAM17 is further discussed in paragraph ACE2 and the Inflammatory Response to Sars-CoV-2.
T120 18068-18188 Sentence denotes Figure 2 summarizes the known transcriptional, post-transcriptional, and post translational regulation pathways of ACE2.
T121 18189-18290 Sentence denotes FIGURE 2 Regulation pathways of transcription, translation, and post-translational shedding of ACE2.
T122 18291-18323 Sentence denotes Red text: non-molecular factors.
T123 18324-18354 Sentence denotes Black text: molecular factors.
T124 18356-18383 Sentence denotes Tissue Distribution of ACE2
T125 18384-18524 Sentence denotes Detectable quantities of ACE2 protein have been found almost ubiquitously in tissues across mammalian species, using immunostaining methods.
T126 18525-18742 Sentence denotes ACE2 is predominantly located in the cardiovascular system and kidney, where it probably plays a role in the maintenance of hydro electrolyte homeostasis (section “Mechanism of Viral Entry Mediated by the S Protein”).
T127 18743-18961 Sentence denotes In fact, ACE2 is pervasively expressed throughout the vasculature, at the level of the arteries and veins, mainly in smooth muscle cells of the media and in the endothelium (Hamming et al., 2004; Burrell et al., 2005).
T128 18962-19052 Sentence denotes Such signal from vessels also delivers part of the expression detected in specific organs.
T129 19053-19391 Sentence denotes Indeed, ACE2 is evident in: coronary vessels and myocardial capillaries (Wiener et al., 2007; Garabelli et al., 2008); lung microvascular endothelial cells (Wiener et al., 2007; Chen et al., 2013); kidney interlobular arteries (Lely et al., 2004); endothelial and smooth muscle cells in the brain (Hamming et al., 2004; Kar et al., 2010).
T130 19392-19569 Sentence denotes Notably, the mesangium and glomerular endothelium in the kidney, and the endothelial lining of the sinusoids in the liver are allegedly negative for ACE2 (Hamming et al., 2004).
T131 19570-19757 Sentence denotes On the contrary, ACE2 is virtually absent from the lymphatic system, and human hemato-lymphoid organs (i.e., spleen, lymph nodes, and bone marrow) (Hamming et al., 2004; Li et al., 2007).
T132 19758-19905 Sentence denotes In blood cells, it has been observed in platelets and macrophages, but not in B and T lymphocytes (Hamming et al., 2004; Fraga-Silva et al., 2011).
T133 19906-20249 Sentence denotes Expression of ACE2 was originally identified in rodent heart (Donoghue et al., 2000a), where it was observed to occur in both atrium an ventricle (Gembardt et al., 2005), and, cellularly, in cardiomyocytes and in specialized cells of the sinoatrial node (Burrell et al., 2005; Garabelli et al., 2008; Ferreira et al., 2011; Wang et al., 2017).
T134 20250-20442 Sentence denotes In human heart, ACE2 has been found in the stromal area in spongiosa layer in aortic valves (Peltonen et al., 2011), where it is expressed in myofibroblasts and fibroblasts (Guy et al., 2008).
T135 20443-20730 Sentence denotes High levels of ACE2 protein expression have been detected in mammalian, including human, kidney (Gembardt et al., 2005; Koka et al., 2008; Reich et al., 2008; Giani et al., 2012; Mitani et al., 2014; Grobe et al., 2015; Shi et al., 2015; Larouche-Lebel et al., 2019; Alawi et al., 2020).
T136 20731-21069 Sentence denotes Strong signals were reported in the brush border of the proximal tubular cells, whereas weak to moderate signals could be found in the glomeruli, Henle’s loop, distal tubules, and collecting duct (Hamming et al., 2004; Lely et al., 2004; Kamilic et al., 2010; Giani et al., 2012; Bae et al., 2015; Cao et al., 2017; Errarte et al., 2017).
T137 21070-21264 Sentence denotes In the respiratory tract of primates, positive labeling for ACE2 has been reported at multiple sites, from the nasal and oral mucosa, to the larynx, trachea, bronchi and lung (Liu et al., 2011).
T138 21265-21550 Sentence denotes Whether ACE2 is expressed in human nasal and oral epithelium remains unclear, as contradictory results have been reported by studies using immunohistochemistry (Hamming et al., 2004; Bertram et al., 2012), in face of positive single-cell RNA sequencing findings (Sungnak et al., 2020).
T139 21551-21721 Sentence denotes This point is of great interest to understand the role of those tissues in SARS-CoV-2 initial infection, spread and clearance (section “Links Between ACE2 and COVID-19”).
T140 21722-21879 Sentence denotes In the upper respiratory tract ACE2 is expressed in the epithelial lining and lamina propria, in some muscle cells and in the salivary gland duct epithelium.
T141 21880-22174 Sentence denotes In the lung, an intense signal for ACE2 protein has been consistently observed in type I and II pneumocytes in several species, including mouse, rat, cat, ferret, monkey and human (Wiener et al., 2007; van den Brand et al., 2008; Liu et al., 2011; Wong et al., 2012; Chen et al., 2013; Zhang B.
T142 22175-22192 Sentence denotes N. et al., 2019).
T143 22193-22357 Sentence denotes Data from rodents suggest an age- and gender-dependent pattern of expression, with a more rapid decline with age in males as compared to females (Xie et al., 2006).
T144 22358-22636 Sentence denotes Although some ACE2 signal has been observed in the liver, it appears to mainly come from small vessel endothelium, and occasionally bile duct epithelial cells, while negligible expression is observed in hepatocytes (Hamming et al., 2004; Paizis et al., 2005; Guan et al., 2020).
T145 22637-22826 Sentence denotes ACE2 protein is abundantly expressed in the brush border of enterocytes of all parts of the small intestine, including the duodenum, jejunum, and ileum, but not in enterocytes of the colon.
T146 22827-23036 Sentence denotes Other organs of the digestive tract, such as the stomach and colon, did not show brush border staining, but rather a positive signal in the muscolaris mucosae and the muscolaris propria (Hamming et al., 2004).
T147 23037-23203 Sentence denotes In rodents, ACE2 is also expressed in both exocrine and endocrine pancreatic tissue, particularly in the islets of Langerhans (Niu et al., 2008; Fang and Yang, 2010).
T148 23204-23294 Sentence denotes ACE2 distribution is widespread in the mouse brain, from the telencephalon to the medulla.
T149 23295-23701 Sentence denotes As expected, ACE2 is found in brain areas involved in the regulation of cardiovascular function and fluid balance, such as the vascular organ of lamina terminalis, subfornical organ, magnocellular neurons in the hypothalamic paraventricular nucleus, area postrema, nucleus of the solitary tract, dorsal motor nucleus of the vagus, nucleus ambiguous, and rostral ventrolateral medulla (Doobay et al., 2007).
T150 23702-23985 Sentence denotes However, significant expression had also been reported in brain areas not engaged in the classical functions of the RAAS, namely the piriform cortex, hippocampus, caudate putamen, hypoglossal nucleus and primary motor cortex (Doobay et al., 2007; Lin et al., 2008; Liu et al., 2014).
T151 23986-24123 Sentence denotes ACE2 immunostaining was identified in neurons as well as astrocytes (Gallagher et al., 2006; Doobay et al., 2007; Yamazato et al., 2007).
T152 24124-24294 Sentence denotes Furthermore, ACE2 has been documented in the retina, predominantly in the inner nuclear layer but also in photoreceptors (Tikellis et al., 2004; Senanayake et al., 2007).
T153 24295-24403 Sentence denotes With regard to the endocrine system, ACE2 expression was found in both male and female reproductive systems.
T154 24404-24541 Sentence denotes In human testis, ACE2 was localized to the Leydig and Sertoli cells, and might be involved in testicular function (Douglas et al., 2004).
T155 24542-24809 Sentence denotes At present, no data about ACE2 protein expression is human ovaries is available, although evidence of expression in stroma, theca, and granulosa cells has been reported in other species (Tonellotto dos Santos et al., 2012; Barreta et al., 2015; Pereira et al., 2015).
T156 24810-24923 Sentence denotes In rodent bone, ACE2 is expressed in osteoblasts and osteoclasts, as well as in epithelial cells and fibroblasts.
T157 24924-25028 Sentence denotes However, a similar expression in human samples still awaits clarification (Queiroz-Junior et al., 2019).
T158 25029-25154 Sentence denotes In human skin, ACE2 was present in the basal cell layer of the epidermis extending to the basal cell layer of hair follicles.
T159 25155-25236 Sentence denotes Smooth muscle cells surrounding the sebaceous glands were also positive for ACE2.
T160 25237-25301 Sentence denotes Weak cytoplasmic staining was observed in sebaceous gland cells.
T161 25302-25386 Sentence denotes A strong granular staining pattern for ACE2 was seen in cells of the eccrine glands.
T162 25387-25567 Sentence denotes Positive staining for ACE2 was also noted in the membrane of human fat cells in various organs, including the epicardial adipose tissue (Hamming et al., 2004; Patel et al., 2016a).
T163 25568-25678 Sentence denotes Globally, ACE2 is chiefly bound to cell membranes, while negligible levels can be detected in the circulation.
T164 25680-25722 Sentence denotes ACE2, the RAAS System and Cardioprotection
T165 25723-25987 Sentence denotes After the initial discovery of ACE2 in the heart and kidney, it is now clear that it is widely distributed in tissues (section Tissue Distribution of ACE2), where it exerts many physiological effects and may be involved in pathophysiological events (Turner, 2015).
T166 25988-26194 Sentence denotes The effect of ACE2 which has been more extensively investigated is the regulation of the RAAS system, where ACE2 counter-balances ACE, limiting the potent vasoconstrictive effect of angiotensin II (Ang-II).
T167 26195-26421 Sentence denotes The first evidence that ACE2 was involved in RAAS control came from the transgenic knockout mouse model (ACE2–/–), which was characterized by severe reduction of cardiac contractility and thinning of the left ventricular wall.
T168 26422-26553 Sentence denotes Interestingly, in this knockout model disruption of the ACE pathway could rescue the myocardial phenotype (Crackower et al., 2002).
T169 26554-26689 Sentence denotes In another study, a selective ACE2 knockout model showed high blood pressure, worsened by the infusion of Ang-II (Gurley et al., 2006).
T170 26690-26828 Sentence denotes As a matter of fact, ACE2 displays its carboxypeptidase activity converting Ang-II to a heptapeptide, namely Ang1–7 (Turner et al., 2004).
T171 26829-27037 Sentence denotes ACE2 can also convert angiotensin I (Ang-I) to the non apeptide Ang1–9, which is in turn converted into Ang1–7 by ACE, competing with Ang-I and thus further decreasing Ang-II (Arendse et al., 2019; Figure 3).
T172 27038-27243 Sentence denotes Ang1–7 has been demonstrated to bind to the MasR receptor, which was initially regarded as an orphan receptor, since the use of a MasR antagonist caused inhibition of Ang1–7 effects (Alenina et al., 2008).
T173 27244-27477 Sentence denotes FIGURE 3 ACE2 signalling pathways: ACE2 displays its carboxypeptidase activity converting Ang-II (ANG II) to ANG1–7 and can also convert angiotensin I (ANG-I) to the nonapeptide Ang1–9, which is in turn converted into ANG1–7 by ACE.
T174 27478-27581 Sentence denotes ANG1-7 binds the MasR receptor to exert its effects on target organs (primarily heart, vessels, lungs).
T175 27582-27720 Sentence denotes ACE2 might also act via the bradykinin-DABK/BKB1R axis: the increased activity of the DABK axis triggers a proinflammatory cytokine storm.
T176 27721-28072 Sentence denotes In the last years the ACE2/Ang1–7/MasR system has been intensively studied: physiological effects on cardiomyocytes include modulation of Ca++ signaling and cytokine production, stimulation of cardiomyocytes progenitors and prevention of uncontrolled cell growth (Grobe et al., 2006; Flores-Muñoz et al., 2012; Souza et al., 2013; Chang et al., 2016).
T177 28073-28320 Sentence denotes Through the Ang1–7 pathway ACE2 produces endothelial antithrombotic effects, vasodilation, nitric oxide release, and inhibits vascular smooth muscle cells (VSMC) proliferation (Loot et al., 2002; Sampaio et al., 2007a,b; Fraga-Silva et al., 2008).
T178 28321-28508 Sentence denotes In preclinical studies Ang1–7 displayed antifibrotic effects, protecting from deleterious myocardial hypertrophy and modulating left ventricle remodeling after myocardial infarction (MI).
T179 28509-28843 Sentence denotes In animal models, Ang1–7 also showed an antiarrhythmic action (Ferreira et al., 2001; Santos et al., 2004; Grobe et al., 2006; Gomes et al., 2010), while compensatory ACE2 upregulation has been observed in explanted human hearts, in patients affected by ischemic or dilated cardiomyopathy (Goulter et al., 2004; Burrell et al., 2005).
T180 28844-28909 Sentence denotes Additional players contribute to ACE2-mediated cardio-protection.
T181 28910-29104 Sentence denotes Another substrate of ACE2 carboxypeptidase activity is Angiotensin A (Ang-A), identified in 2008, which has a similar, although less potent, vasopressor effect as AngII (Jankowski et al., 2007).
T182 29105-29248 Sentence denotes The product of the enzymatic reaction catalyzed by ACE2 is the peptide Ala-Ang (1–7) also known as alamandine (Lautner et al., 2013; Figure 3).
T183 29249-29384 Sentence denotes Alamandine receptor is a Mas-related G-protein coupled receptor, known as MrgD, which is expressed in cardiomyocytes and blood vessels.
T184 29385-29527 Sentence denotes MrgD knockout animals develop a severe cardiopathy and alamandine showed a cardioprotective effect in a model of sepsis (Santos et al., 2019).
T185 29528-29758 Sentence denotes Unlike ACE, ACE2 is not active on bradykinin, but it can degrade the active bradykinin metabolite des-Arg9 bradykinin (DABK), blocking the signaling pathway of the B1 bradykinin receptor (Vickers et al., 2002; Sodhi et al., 2018).
T186 29759-29866 Sentence denotes Other substrates of ACE2 include apelin-13/17, neurotensin, dynorphin A (1–13), and ghrelin (Turner, 2015).
T187 29867-30069 Sentence denotes Interestingly peptides of apelin family have been demonstrated to upregulate ACE2 expression in physiological condition and more actively during heart failure in in vivo experiments (Sato et al., 2013).
T188 30070-30334 Sentence denotes ACE2 in turn is able to regulate apelin bioavailability, establishing a negative feedback loop, and the crosstalk between RAAS, ACE2 and Apelin system might play a significant role in the pathophysiology of hypertension (Kalea and Batlle, 2010; Chen et al., 2015).
T189 30335-30689 Sentence denotes On the whole these findings suggest that ACE2 might exert antihypertensive and/or cardioprotective effects by different mechanisms, namely: (i) limiting the availability of ACE substrates, (ii) degrading Ang-II, (iii) activating the Ang1-7/MasR and/or Alamandine/MrgD pathways, (iv) interfering with other substrates, such as DABK and apelins (Figure 3).
T190 30691-30711 Sentence denotes ACE2 and Lung Injury
T191 30712-30846 Sentence denotes ACE2 is highly expressed in type I and II alveolar epithelial cells and in pulmonary small vessels (either endothelial cells or VSMC).
T192 30847-31153 Sentence denotes The hypothesis that the ACE2 arm of the RAAS system could be of benefit in lung disease derives from the observation that ACE and angiotensin II are upregulated in acute lung injury (ALI), pulmonary fibrosis, pulmonary hypertension, and acute respiratory distress syndrome (ARDS) (Imai et al., 2005, 2010).
T193 31154-31375 Sentence denotes ARDS is an overly aggressive form of ALI and it is the final mechanism of lung injury in many diseases, including sepsis, acid aspiration, pancreatitis, anthrax and virus infections (Spanish flu, H5N1 avian flu and SARS).
T194 31376-31521 Sentence denotes Imai et al. developed three ACE2 knockout mice models with severe ARDS induced by acid aspiration, endotoxin administration or peritoneal sepsis.
T195 31522-31743 Sentence denotes They showed that ARDS was accompanied by increased vessel permeability, lung oedema, and infiltration of inflammation cells, with consequent impairment of respiratory function (Imai et al., 2005, 2007; Kuba et al., 2006).
T196 31744-31888 Sentence denotes The phenotype was dramatically improved and rescued either administering ACE2 recombinant analogs or AT1Ra inhibitors (Imai et al., 2005, 2008).
T197 31889-32139 Sentence denotes ACE2 may also reduce lung inflammation via Ang1–7/MasR, since treatment with recombinant Ang1–7 in a model of allergic asthma reduced eosinophil mobilization, peri-bronchial inflammation, fibrosis and goblet cells metaplasia (El-Hashim et al., 2012).
T198 32140-32338 Sentence denotes An anti-inflammatory effect with reduction of airway remodeling has also been demonstrated in another model of chronic asthma, after administration of Ang1–7 analog (Rodrigues-Machado et al., 2013).
T199 32339-32561 Sentence denotes The underlying mechanism seems to be the modulation of the so-called cytokine storm and particularly the inhibition of transforming growth factor β (TGF- β) and NFkB signaling pathways (Li et al., 2015; Meng et al., 2015).
T200 32562-32640 Sentence denotes ACE2 might also modulate lung inflammation via the bradykinin-DABK/BKB1R axis.
T201 32641-32860 Sentence denotes In fact, decreased ACE2 function in mouse lungs caused increased activity of the DABK axis and triggered a proinflammatory cytokine storm (CXCL5, MIP2, KC, and TNF-α), leading to pulmonary collapse (Sodhi et al., 2018).
T202 32861-32924 Sentence denotes In human, ACE/ACE2 imbalance may be related to genetic factors.
T203 32925-33149 Sentence denotes In particular, a specific polymorphism of the ACE gene, namely ACE D, which determines increased ACE activity and decreased ACE2 activity has been correlated to ARDS susceptibility and mortality rate (Marshall et al., 2002).
T204 33150-33370 Sentence denotes More recently, high levels of angiotensin II have been reported in patients infected with avian influenza viruses H5N1 and H7N9, and they were strongly predictive of a poor outcome (Huang et al., 2014; Zou et al., 2014).
T205 33372-33403 Sentence denotes Links Between ACE2 and COVID-19
T206 33404-33652 Sentence denotes A “second life” for ACE2 was discovered in 2003, when a novel respiratory infective disease, known as severe acute respiratory syndrome (SARS), appeared in China and spread all over Asia and Canada, with a lethality rate of 10% (Rota et al., 2003).
T207 33653-33802 Sentence denotes The responsible pathogen was identified in a positive strand RNA virus belonging to the coronavirus family and named SARS-CoV (Ksiazek et al., 2003).
T208 33803-34023 Sentence denotes The virus genome was sequenced and this allowed the identification of the spike glycoprotein (S), whose N-terminal portion, or S1-domain, was found to mediate the high affinity binding to host cells (Marra et al., 2003).
T209 34024-34311 Sentence denotes The group of Farzan et al. succeeded in identifying the cell receptor: they showed that SARS-CoV efficiently infected African Monkey kidney cell line Vero E6 and co-immunoprecipitated a glycoprotein responsible for virus binding and entry, which was identified as ACE2 (Li et al., 2003).
T210 34312-34418 Sentence denotes SARS-CoV caused the SARS epidemic in 2002–2003, with over 8,000 infections and a fatality rate around 10%.
T211 34419-34615 Sentence denotes In late 2019, another coronavirus emerged as a human pathogen in the city of Wuhan in China, producing symptoms such as fever, severe respiratory impairment, and pneumonia (Petersen et al., 2020).
T212 34616-34794 Sentence denotes This new coronavirus has been denominated SARS-CoV-2 for its genetic resemblance with SARS-CoV (∼80%), and its related disease has been named COVID-19 (COronaVIrus Disease 2019).
T213 34795-34955 Sentence denotes Owing to its high reproduction number R0 (2–3), SARS-CoV-2 has rapidly diffused in several countries and is currently posing a significant global health threat.
T214 34956-35029 Sentence denotes On March 11, 2020, the WHO has declared the COVID-19 outbreak a pandemic.
T215 35030-35224 Sentence denotes The early discovery that SARS-CoV-2 also engages ACE2 as entry door for cell infection has prompted an intense research effort to elucidate the biochemical determinants of CoV-ACE2 interactions.
T216 35226-35276 Sentence denotes Mechanism of Viral Entry Mediated by the S Protein
T217 35277-35402 Sentence denotes A coronavirus contains four structural proteins, namely spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins.
T218 35403-35529 Sentence denotes These proteins assemble around a lipid bilayer to provide the shell enclosing the viral genome (Figure 4A; Tang et al., 2020).
T219 35530-35721 Sentence denotes Homotrimers of S protrude from the viral surface, and are densely decorated by N-linked glycans, creating the “crown” (“Corona” in Latin) that christens this virus group (Walls et al., 2016).
T220 35722-35876 Sentence denotes S is a ∼180 kDa glycoprotein anchored in the viral membrane, which plays the most important roles in viral attachment, fusion and entry (Ou et al., 2020).
T221 35877-36027 Sentence denotes Sequence analysis has shown that SARS-CoV-2 S protein shares 76% of the primary sequence with the corresponding S of human SARS-CoV (Ou et al., 2020).
T222 36028-36158 Sentence denotes Accordingly, it has been early proposed that SARS-CoV-2 utilizes a similar cell entry mechanism as SARS-CoV, pivoted on S protein.
T223 36159-36229 Sentence denotes This hypothesis has been confirmed from an experimental point of view.
T224 36230-36442 Sentence denotes By using pseudotyped virus bearing SARS-CoV S or SARS-CoV-2 S, it was shown that a large panel of cell lines allows comparable entry of SARS-CoV or SARS-CoV-2 viruses (Hoffmann et al., 2020b; Walls et al., 2020).
T225 36443-36575 Sentence denotes FIGURE 4 (A) Structure of a Coronavirus. (B) Functional motifs in the sequence of the S “spike” protein of SARS-CoV and SARS-CoV-2.
T226 36576-36857 Sentence denotes The S protein consists of ∼1300 aminoacids and it is composed by a N-terminal “S1”subunit (∼700 aa) and a C-terminal “S2”subunit (∼600 aa); binding to the host receptor is mediated by S1, whereas S2 induces fusion of the viral envelope with cellular membranes (Walls et al., 2017).
T227 36858-36984 Sentence denotes S1 and S2 can be further subdivided in functional segments with different roles in viral entry (Figure 4B; Tang et al., 2020).
T228 36985-37085 Sentence denotes The S1 subunit contains two subdomains, the N-terminal domain (NTD) and the C-terminal domain (CTD).
T229 37086-37289 Sentence denotes In SARS-CoV (Li, 2015) and SARS-CoV-2 (Wang et al., 2020) CTD encloses the receptor-binding domain (RBD), and the RBD section that directly contacts the receptor is named as receptor-binding motif (RBM).
T230 37290-37443 Sentence denotes The N-region of S2 contains a fusion peptide (FP), two heptapeptide repeat domains (HR1, HR2), a transmembrane domain (TM), and cytoplasmic peptide (CP).
T231 37444-37611 Sentence denotes FP is a short segment composed of mostly hydrophobic residues, such as glycine (G) or alanine (A), which inserts in the host cell membrane to trigger the fusion event.
T232 37612-37795 Sentence denotes HR1 and HR2 are composed of a repetitive heptapeptide with HPPHCPC sequence, where H represents hydrophobic or bulky residues, P polar or hydrophilic residues, and C charged residues.
T233 37796-37894 Sentence denotes HR regions typically fold into α-helices with a hydrophobic interface that drives membrane fusion.
T234 37895-38092 Sentence denotes On the basis of the strong similarity between the S proteins of SARS-CoV and SARS-CoV-2, many researchers early set-out to demonstrate whether both viruses target the same host cell receptor, ACE2.
T235 38093-38251 Sentence denotes Zhou et al. (2020) highlighted that the virus was able to infect cell lines only when they expressed human, bat, civet, and pig (but not mouse) ACE2 receptor.
T236 38252-38443 Sentence denotes Hoffmann et al. (2020b), Ou et al. (2020), and Walls et al. (2020) elegantly outlined that the BHK cell line could be infected by pseudotyped SARS-CoV-2 or SARS-CoV only upon ACE2 expression.
T237 38444-38649 Sentence denotes Conversely, the expression of different human receptors used by other CoVs (hDPP4 and APN, used by MERS CoV and HCoV-229E, respectively) did not enable pseudovirus access to cells (Hoffmann et al., 2020b).
T238 38650-38744 Sentence denotes Taken together, these findings are solid evidence that SARS-CoV-2 engages ACE2 for cell entry.
T239 38745-38968 Sentence denotes Nonetheless, the two viruses were demonstrated by Xia to share also the membrane fusion mechanism, as strongly suggested by the impressive 89.9% sequence identity of S2 between SARS-CoV and SARS-CoV-2 (Xia et al., 2020a,b).
T240 38969-39194 Sentence denotes To date, the cell entry mechanism of SARS-CoV and SARS-CoV-2 has been understood in its general details and it is based on a concerted action of receptor binding and proteolysis of the S protein (Figure 5; Tang et al., 2020).
T241 39195-39386 Sentence denotes Ultrastructural studies showed a metastable “prefusion” V-shaped trimer composed by three S1 heads sitting on top of a trimeric S2 stalk anchored into the virus membrane (Walls et al., 2016).
T242 39387-39604 Sentence denotes The RBD constantly switches between a standing-up (“open”) position for receptor binding and a lying-down (“closed”) configuration, the latter allowing immune evasion (Figure 6; Song et al., 2018; Wrapp et al., 2020).
T243 39605-39723 Sentence denotes Yet only one of the three RBD in trimeric S can flip up at a time and interact with the receptor (Wrapp et al., 2020).
T244 39724-39886 Sentence denotes The second key feature of the fusion mechanism is “priming” by host proteases, which recognize and cleave a short peptide motif at the S1/S2 boundary (Figure 4B).
T245 39887-40250 Sentence denotes This cleavage does not disassemble S1 from S2 in pre-fusion conditions (Belouzard et al., 2009), but the binding interaction of RBD with its receptor, accompanied by a further cleavage in a second site in S2 (S2’site, upstream of FP, Figure 4B), triggers the possible dissociation of S1 and the irreversible refolding of S2 into a “post-fusion” state (Figure 4B).
T246 40251-40486 Sentence denotes In detail, HR1 undergoes a dramatic “jack-knife” conformational change, converting four helical stretches that run in an antiparallel fashion into a single long (∼130 aa) α-helix (Heald-Sargent and Gallagher, 2012; Walls et al., 2017).
T247 40487-40601 Sentence denotes At first, three of these helices assemble into a homotrimeric bundle and stick the FP into the host cell membrane.
T248 40602-40756 Sentence denotes Then, HR2 (one for each S2 chain) fold backward and bind to HR1, yielding the “six-helix bundle fusion core” (6-HB) of post-fusion S2 (Song et al., 2018).
T249 40757-40989 Sentence denotes This conformational foldback brings the FP (at N-terminus of HR1) and the TM (at the C terminus of HR2) close to each other, so that the viral and host cell membranes approach until their outer leaflets merge (hemifusion, Figure 5).
T250 40990-41200 Sentence denotes Eventually the inner leaflets merge (pore formation), enabling a connection between the interior of the virus and the host cell cytoplasm, that allows the delivery of viral genome (Figure 5; Tang et al., 2020).
T251 41201-41250 Sentence denotes FIGURE 5 Coronavirus viral fusion pathway model.
T252 41251-41314 Sentence denotes Initially, the S protein is in the pre-fusion native state (1).
T253 41315-41613 Sentence denotes Then S undergoes priming of the S1 subunit at S1/S2 by local proteases yielding the pre-fusion metastable state (2); note that priming at S1/S2 could also happen upon virus formation in releasing cell: in such a case the virus attaches to a host cell already in the pre-fusion metastable state (2).
T254 41614-41793 Sentence denotes Subsequent triggering by a protease on S2’ enables the FP to insert in the host membrane upon the “jack-knife” transition of HR1 and HR2 yielding the pre-hairpin intermediate (3).
T255 41794-41908 Sentence denotes The pre-hairpin folds back on itself due to HR1 and HR2 interactions eventually forming the post-fusion (6) state.
T256 41909-42079 Sentence denotes During the S protein foldback, the two membranes approach each other until the outer leaflets merge (hemifusion) and eventually the inner leaflets merge (pore formation).
T257 42080-42201 Sentence denotes Note that cell membrane may refer to plasma membrane (direct fusion) or endosomal membrane (fusion in endocytic vesicle).
T258 42202-42234 Sentence denotes Adapted from Tang et al. (2020).
T259 42235-42311 Sentence denotes FIGURE 6 Trimeric S protein of SARS-CoV-2 in the ”Closed” and “Open” forms.
T260 42312-42400 Sentence denotes Note the single RBD protruding out of the V-shaped conformation of the protein assembly.
T261 42401-42449 Sentence denotes The structures have been drawn from PDB 6X2C (R.
T262 42450-42513 Sentence denotes Henderson, 10.1101/2020.05.18.10208) by Mol on the PDB website.
T263 42514-42683 Sentence denotes Although not directly related to ACE2, the role of S “priming” by host cell proteases deserves particular attention in the context of SARS-CoV-2 virus entry and tropism.
T264 42684-42896 Sentence denotes Possibly, the most notable feature of SARS-CoV-2 genome, as compared to SARS-CoV and some related bat coronaviruses, is a four basic aminoacid insert (PRRA) at the S1/S2 junction (Figure 4B; Jaimes et al., 2020).
T265 42897-43052 Sentence denotes This site is potentially cleavable by the protease furin, a proprotein convertase widely recognized to activate the fusion machinery of viral glycoprotein.
T266 43053-43285 Sentence denotes Indeed, many authors showed that pseudoviruses bearing SARS-CoV-2 S were already “primed” (i.e., cleaved) at the S1/S2 boundary by furin upon assembly in the cell, at odds with pseudoviruses bearing SARS-CoV S (Shang et al., 2020a).
T267 43286-43679 Sentence denotes SARS-COV-2 shows a large flexibility with regard to protease priming, which may independently occur by a) furin and furin-like proteases intracellularly, b) trypsin-like proteases such as TMPRSS2 that are present on the host cell membrane (particularly on airway epithelial cells), and 3) endosomal cathepsins activated by a drop in pH (e.g., cathepsin L) (Figure 7; Hoffmann et al., 2020a,b).
T268 43680-43831 Sentence denotes This flexibility could be the crucial factor that explain SARS-CoV-2 cell tropism and the peculiar features of COVID-19 symptoms (Jaimes et al., 2020).
T269 43832-44017 Sentence denotes Additionally, the kind of protease “priming” may determine whether the membrane fusion process occur directly at the plasma membrane or at endosomal level (Tang et al., 2020; Figure 7).
T270 44018-44103 Sentence denotes FIGURE 7 Relevance of S S1/S2 “priming” by host proteases for viral fusion to cells.
T271 44104-44264 Sentence denotes The left cells produce viruses that can be “primed” by endogenous proteases such as furin (blue scissors); other viruses are not primed when they exit the cell.
T272 44265-44490 Sentence denotes The primed viruses (marked by a yellow internal shadow) reach another cell (pathway A), where a membrane protease (e.g., TMPRSS2) may cleave the S2’ site (see Figure RB1b) leading to membrane fusion and delivery of viral RNA.
T273 44491-44801 Sentence denotes Non-primed viruses can deliver their genome by two routes: in B, the virus reaches the cell, is primed on the membrane at both S1/S2 and S2’ by a local protease and then fuse with the plasma membrane; alternatively, in C the virus is internalized by endocytosis and priming/fusion occurs in endocytic vesicles.
T274 44802-44912 Sentence denotes Note that also “primed” viruses may undergo pathway C, depending on their interaction with the recipient cell.
T275 44914-44951 Sentence denotes SARS-CoV-2 RBD and Its Receptor, ACE2
T276 44952-45099 Sentence denotes Since SARS-CoV-2 and SARS-CoV share the same host cell receptor, it was early questioned whether SARS-CoV-2 retains the same RBD motif of SARS-CoV.
T277 45100-45176 Sentence denotes SARS-CoV RBD corresponds to residues 306–527 of S protein (Li et al., 2005).
T278 45177-45316 Sentence denotes Sequence analysis shows that residues 319–541 of SARS-CoV-2 (S319–341) share 73.9% sequence identity with SARS-CoV RBD (Wang et al., 2020).
T279 45317-45447 Sentence denotes Accordingly, Wang et al. (2020) clearly demonstrated that S319–341 corresponds to SARS-CoV-2 RBD by immunofluorescence microscopy.
T280 45448-45651 Sentence denotes Indeed SARS-CoV-2 S1 and S319–341 positively colocalized with GFP-tagged ACE2 expressed on cell surface of HEK cells, whereas this interaction did not occur with membrane-expressed hDPP4 (MERS receptor).
T281 45652-45781 Sentence denotes Additionally, soluble ACE2 inhibited the interaction between viral proteins and ACE2-expressing cells in a dose-dependent manner.
T282 45782-45858 Sentence denotes The SARS-CoV-2 RBD sequence was further investigated by structural analysis.
T283 45859-46256 Sentence denotes X-ray crystallography showed that SARS-CoV-2 RBD folds into two structural domains (Figure 8): (1) the core subdomain with five antiparallel β-strands (β1, β2, β3, β4, β7), (2) the external subdomain, which inserts between β4 and β7, and it is characterized by the two small β5 and β6 strands [β1’ and β2’ in Wang et al. (2020)] connected by a disulfide bond (Lan et al., 2020; Wang et al., 2020).
T284 46257-46524 Sentence denotes In keeping with their high sequence homology, the 3D structure of SARS-COV-2 and SARS-CoV RBD nearly superimpose (RMSD = 0.475 Å for 128 Cα atoms; Wang et al., 2020) with the exception of the β5/β6 loop, which actually entailed the larger primary sequence difference.
T285 46525-46759 Sentence denotes FIGURE 8 Crystal structure of SARS-CoV-2 spike receptor-binding domain bound with ACE2. (A) Cartoon representation. (B) Gaussian surface representation. hACE2 is in green, the core of SARS-CoV-2 RBD is in red, and the RBM is in blue.
T286 46760-46832 Sentence denotes The β1-β7 typical motifs of RBD (Lan et al., 2020) are indicated in (A).
T287 46833-46923 Sentence denotes The structures have been drawn from PDB 6MOJ (Lan et al., 2020) by Mol on the PDB website.
T288 46924-47001 Sentence denotes Several researchers investigated the interaction of SARS-CoV-2 RBD with ACE2.
T289 47002-47088 Sentence denotes Unfortunately, each group committed to slightly different sequences of SARS-CoV-2 RBD.
T290 47089-47249 Sentence denotes To avoid confusion, we will always report the actual sequence with respect to the S protein when the RBD under study differs from the canonical 319–541 stretch.
T291 47250-47364 Sentence denotes In vitro affinity studies revealed dissociation constants of the ACE2-RBD complex in the 1–100 nM range (Table 1).
T292 47365-47513 Sentence denotes Non univocal data are attributable to the dissimilar sequences that were investigated and/or to the immobilization procedures (Shang et al., 2020b).
T293 47514-47705 Sentence denotes In spite of this variability, SARS-CoV-2 RBD was always found to bind ACE2 4–10 fold stronger than SARS-CoV RBD (Lan et al., 2020; Shang et al., 2020b; Walls et al., 2020; Wang et al., 2020).
T294 47706-47923 Sentence denotes The affinity difference in vitro was confirmed also in vivo by the stronger binding of SARS-CoV-2 S331–524 to ACE2 expressed on cells (SARS-CoV-2: EC50 = 0.08 μg/ml vs. SARS-CoV: EC50 = 0.96 μg/ml) (Tai et al., 2020).
T295 47924-48101 Sentence denotes Paradoxically, however, it has been shown that the ACE2 binding affinity for the entire SARS-CoV-2 S protein is lower than or comparable to that of SARS S (Shang et al., 2020a).
T296 48102-48345 Sentence denotes This surprising result suggests that SARS-CoV-2 RBD, albeit more potent, is less efficiently exposed than SARS-CoV RBD by the dynamic transition between the “closed” and “open” states, probably in order to escape the immune system of the host.
T297 48346-48672 Sentence denotes Thus, the non-identical S1 sequences of SARS-CoV-2 and SARS-CoV reflect the molecular evolution of SARS-CoV-2 toward: (1) much stronger affinity toward ACE2, (2) reduced antigenicity of the RBD region (which is one of the most antigenic segments in the S protein), (3) greater and less specific cleavability by host proteases.
T298 48673-48790 Sentence denotes Taken together, these properties account for the sophisticated strategy exploited by SARS-CoV-2 to invade host cells.
T299 48791-48884 Sentence denotes TABLE 1 Binding affinity between SARS-CoV-2 spike (S) protein and S subset regions and ACE2.
T300 48885-48922 Sentence denotes Sequence KD (nM) Method References
T301 48923-48962 Sentence denotes SARS-2 S 14.7 SPR Wrapp et al., 2020
T302 48963-49000 Sentence denotes SARS-2 S 11.2 SPR Lei et al., 2020
T303 49001-49050 Sentence denotes SARS-2 S20–685 (S1) 94.6 SPR Wang et al., 2020
T304 49051-49103 Sentence denotes SARS-2 S319–541 (RBD) 133.3 SPR Wang et al., 2020
T305 49104-49153 Sentence denotes SARS-2 S319–541 (RBD) 4.7 SPR Lan et al., 2020
T306 49154-49201 Sentence denotes SARS-2 S319–529 44.2 SPR Shang et al., 2020b
T307 49202-49268 Sentence denotes SARS-2 S319–591 34.6 Biolayer interferometry Wrapp et al., 2020
T308 49269-49334 Sentence denotes SARS-2 S328–533 1.2 Biolayer interferometry Walls et al., 2020
T309 49336-49369 Sentence denotes Structure of the ACE2-RBD Complex
T310 49370-49603 Sentence denotes Previous studies showed that the extracellular Peptidase Domain (PD) of ACE2, which adopts a claw-like morphology, is the interaction site of SARS-CoV RBD (Towler et al., 2004; Li, 2015; Kirchdoerfer et al., 2018; Song et al., 2018).
T311 49604-49778 Sentence denotes More specifically, ACE2 engages SARS-CoV RBD by establishing contacts with the 424–494 residue domain, which is referred to as Receptor Binding Motif (RBM) (Li et al., 2005).
T312 49779-50059 Sentence denotes In spite of the recent emergence of SARS-CoV-2, multiple authors have already highlighted the structure of ACE2/SARS-CoV-2 RBD complex by either X-ray (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020) or cryo-EM (Walls et al., 2020; Wrapp et al., 2020; Yan et al., 2020).
T313 50060-50170 Sentence denotes Pleasantly, all data converged to a consistent tridimensional arrangement of the receptor (Wang et al., 2020).
T314 50171-50288 Sentence denotes In the “closed” conformation of S protein, the RBD is buried at the interface between protomers (Walls et al., 2020).
T315 50289-50471 Sentence denotes Only in the “open” S conformation, RBD engages PD of ACE2 (Wrapp et al., 2020), and the complex may involve a dimeric ACE2 that accommodates two S protein trimers (Yan et al., 2020).
T316 50472-50661 Sentence denotes In keeping with their sequence similarity, strong structural homology was found between ACE2/SARS-CoV RBD and ACE2/SARS-CoV-2 RBD (Lan et al., 2020; Shang et al., 2020b; Wang et al., 2020).
T317 50662-50850 Sentence denotes SARS-CoV-2 RBM spans from residue 438–506 of S sequence and, likewise SARS-CoV RBM, it approaches the outer surface of ACE2 by a gently concave surface with a ridge on one side (Figure 8).
T318 50851-51016 Sentence denotes The concave surface is made up by the two short β5 and β6 sheets of the external RBD subdomain, whereas the ridge contains the β5/β6 loop (loop 1: residues 474–489).
T319 51017-51118 Sentence denotes A second smaller loop (loop 2: residues 498–505) is visible on the other side of the concave surface.
T320 51119-51384 Sentence denotes Inspection of the complex structure and molecular dynamics (MD) highlighted that the motifs 453–456 (in β5), 484–489 (in the loop 1), and 500–505 (in the loop 2) are at the basis of the largest differences between SARS-CoV-2 and SARS-CoV RBM interactions with ACE2.
T321 51385-51639 Sentence denotes SARS-CoV RBM ridge contains a Pro-Pro-Ala motif that is replaced by Gly-Val-Glu-Gly in SARS-CoV-2 (residues 482–485), yielding a more compact loop able to engage more interactions with proximal ACE2 residues (e.g., Ser19 and Gln24) (Shang et al., 2020b).
T322 51640-51848 Sentence denotes Additionally, Phe486 of SARS-CoV-2 RBM (which replaces Ile of SARS) inserts into a hydrophobic pocket on the receptor surface, establishing strong aromatic interactions with Tyr83 of ACE2 (Wang et al., 2020).
T323 51849-51944 Sentence denotes Asn501 in loop 2 further engages recognized hotspots on the ACE2 surface (Shang et al., 2020b).
T324 51945-52096 Sentence denotes Consistently, MD studies confirmed that loop 1 and 2 are much more rigid in RBM-ACE2 complex of SARS-CoV-2 with respect to SARS (Brielle et al., 2020).
T325 52097-52217 Sentence denotes These subtle structural differences probably account for the higher affinity of SARS-CoV-2 for ACE2 (Wang et al., 2020).
T326 52218-52427 Sentence denotes Interestingly, MD simulations suggest that the difference in affinity is largely due to the solvation energy, emphasizing the relevant role of hydrophobic patches in RBM/ACE2 binding surface (He et al., 2020).
T327 52428-52695 Sentence denotes It is worth noting that the RBD-receptor engagement is the crucial effector of viral-host interaction, which eventually determines viral host range, and in tandem with the host proteases is responsible for virus tropism and pathogenicity (Millet and Whittaker, 2015).
T328 52696-52930 Sentence denotes Structure-guided sequence analysis has suggested that several mammals, including pets such as cats and dogs, host ACE2 receptors that could bind effectively to SARS-CoV-2 S protein and propagate COVID-19 infection (Luan et al., 2020).
T329 52931-53013 Sentence denotes Yet, no correlation between genetic distance and the S/ACE2 interaction was found.
T330 53014-53225 Sentence denotes In this context, a third human CoV, hCoV-NL63, has been previously found to use ACE2 for cell entry (Hofmann et al., 2005), although its S1 sequence is rather dissimilar from SARS (23.4%) and SARS-CoV-2 (29.2%).
T331 53226-53398 Sentence denotes In spite of this, the structures of hCoV-NL63 (Wu et al., 2009) and SARS-CoV RBD (Li et al., 2005) were found to engage some sterically overlapping sites in ACE (Li, 2015).
T332 53399-53559 Sentence denotes This homology can be transitively extended to SARS-CoV-2, suggesting these three CoVs have evolved to recognize a “hotspot” region in ACE2 for receptor binding.
T333 53560-53753 Sentence denotes This might represent a critical feature for the appearance of novel CoV able to infect humans in the future, as it is known that at least three more bat CoVs bind ACE2 (Hoffmann et al., 2020b).
T334 53754-53977 Sentence denotes Indeed, bat RaTG13 CoV binds ACE2 and contains a similar four-residue motif in the ACE2 binding ridge of RBM, suggesting that SARS-CoV-2 could have evolved from RaTG13 or a yet-unknown related bat CoV (Shang et al., 2020b).
T335 53979-54020 Sentence denotes The Controversial Role of ACE2 Expression
T336 54021-54261 Sentence denotes Epidemiological data consistently show that the COVID-19 patients at highest risk of a poor prognosis are males older than 60 years with chronic underlying diseases, mostly hypertension, cardiovascular diseases and type-2 diabetes mellitus.
T337 54262-54444 Sentence denotes Clinical reports have been rapidly delivered from all over the world, and meta-analyses assessing the prevalence of comorbidities and their impact on prognosis are already available.
T338 54445-54692 Sentence denotes A meta-analysis pooling data from seven studies following a total number of 1,576 infected patients from hospitals in China found that the most prevalent comorbidities were hypertension (21.1%), diabetes (9.7%), and cardiovascular diseases (8.4%).
T339 54693-54901 Sentence denotes These increased the risk of developing a more serious disease (i.e., requiring intensive care treatment), with odds ratios ranging from 2.4 (hypertension) to 3.4 (cardiovascular disease) (Yang et al., 2020b).
T340 54902-55177 Sentence denotes These findings have been confirmed in the analysis performed by the Chinese Center for Disease Control and Prevention in a huge sample of 72314 COVID-19 cases (Epidemiology Working Group for Ncip Epidemic Response and Chinese Center for Disease Control and Prevention, 2020).
T341 55178-55331 Sentence denotes A study with 1591 Italian patients, similarly, reported a significant association between hypertension and mortality in Intensive Care Unit (63 vs. 40%).
T342 55332-55476 Sentence denotes This series reported an even higher prevalence of hypertension (49%), diabetes (17%), and cardiovascular disease (21%) (Grasselli et al., 2020).
T343 55477-55665 Sentence denotes Diabetes has been reported to predict the occurrence of ARDS (HR = 1.44), acute kidney injury (HR = 3.01), septic shock (HR = 1.95), and all-cause mortality (HR = 1.70) (Zhu et al., 2020).
T344 55666-55824 Sentence denotes Notably, poor glycemic control was significantly associated with worse clinical outcomes, namely multi-organ injuries and higher mortality (Zhu et al., 2020).
T345 55825-55906 Sentence denotes Obesity has also emerged as an important factor in determining COVID-19 severity.
T346 55907-56175 Sentence denotes Indeed, obesity was more frequent in patients admitted to critical care for SARS-CoV-2 as compared to the general population; moreover, the BMI was positively related to the need for invasive mechanical ventilation and mortality (Drucker, 2020; Simonnet et al., 2020).
T347 56176-56318 Sentence denotes The RAAS system is the target of widely used anti-hypertensive drugs, such as ACE-inhibitors (ACEI) and Ang-II type 1 receptor blockers (ARB).
T348 56319-56531 Sentence denotes Several experimental studies reported that, although not directly affecting ACE2 activity, these drugs are able to upregulate its expression (Ishiyama et al., 2004; Ferrario et al., 2005; Gallagher et al., 2008).
T349 56532-56764 Sentence denotes Increased expression of ACE2 has also been reported to facilitate SARS-CoV infection in several experimental models and postulated to act in the same way for SARS-CoV-2 (Li et al., 2003; Hofmann et al., 2004; Perrotta et al., 2020).
T350 56765-56935 Sentence denotes Hence, following the SARS-CoV-2 outbreak, it has been speculated that the use of ACEI and ARB could increase viral invasion and should therefore be temporarily suspended.
T351 56936-57404 Sentence denotes This topic has been abundantly debated in the last few months (March–May 2020), with contradictory views (Bavishi et al., 2020; Buckley et al., 2020; Danser et al., 2020; Fang et al., 2020; Huang Z. et al., 2020; Kreutz et al., 2020; Kuster et al., 2020; Mourad and Levy, 2020; Park et al., 2020; Rico-Mesa et al., 2020; Sommerstein et al., 2020; South et al., 2020; Tignanelli et al., 2020; Vaduganathan et al., 2020; Verdecchia et al., 2020b; Zhang P. et al., 2020).
T352 57405-57794 Sentence denotes As a consequence of this debate, several clinical societies have stated that suspension of ACEI and ARB is not justified on the basis of the present scientific evidence, although a recent BMJ editorial (Aronson and Ferner, 2020) suggested to consider stopping ACE inhibitors or angiotensin receptor blockers in patients with mild hypertension who are at high risk of coronavirus infection.
T353 57795-58020 Sentence denotes On the other hand, a different viewpoint is based on the intriguing observation that several conditions increasing the risk of viral infection and disease severity are all characterized by a certain degree of ACE2 deficiency.
T354 58021-58208 Sentence denotes As discussed above (section “Structure of ACE2”) ACE2 deficiency has been suggested to play a significant role in the pathophysiology of hypertension, cardiovascular disease and diabetes.
T355 58209-58406 Sentence denotes The role of ACE2 expression in the panel of comorbidities correlated to SARS-CoV-2 is a matter of intense still unsolved debate, as brilliantly revised by Shyh et al. (2020) in a very recent paper.
T356 58407-58546 Sentence denotes On the whole, there is still uncertainty about the relationship between ACE2 density on cell membrane and the fate of SARS-CoV-2 infection.
T357 58547-58888 Sentence denotes An interesting speculation which could reconcile the two position comes from the hypothesis that while ACE2 is for sure the entry door for the virus, once the infection has evolved, there is the subsequent downregulation of ACE2, responsible for the precipitating of respiratory distress, as showed also in animal models (Kuba et al., 2005).
T358 58889-59061 Sentence denotes It should be pointed out that the great clinical impact of this issue has encouraged discussions that are largely based on indirect speculations rather than objective data.
T359 59062-59355 Sentence denotes Data from appropriate clinical trials are still lacking, although a retrospective multicenter study on more than 1,000 patients with COVID-19 and hypertension treated with ACEI or ARB revealed that the use of these drugs was associated with lower mortality from all cause (Bosso et al., 2020).
T360 59356-59760 Sentence denotes A definite conclusion would require specific prospective clinical trials, which are still running: https://clinicaltrials.gov/ct2/show/NCT04312009 is a multi-centered double blind trial with the aim to test the role of ARB in patients with COVID-19 and https://clinicaltrials.gov/ct2/show/NCT04331574 is another trial evaluating the outcome of patients with COVID-19 in therapy with either ACEI and ARBS.
T361 59761-60316 Sentence denotes In the meanwhile, partial but important information might be obtained by circumscribed experimental and clinical investigations focused some on crucial issues, namely: fate of SARS-CoV-2 infection in human cells manipulated in order to modify ACE2 density; correlation of ACE2 density (in different cell types) and clinical course in human patients; potential role of additional proteins interacting with ACE2, such as the membrane transporter SIT1, which appears to be associated with COVID-19 prognosis and is also affected by anti-hypertensive therapy.
T362 60318-60366 Sentence denotes ACE2 and the Inflammatory Response to SARS-CoV-2
T363 60367-60533 Sentence denotes Differently from other flu-like viral infections, COVID19 showed a relatively high lethality, although the latter was quite different in different geographical areas.
T364 60534-60693 Sentence denotes The appearance of ARDS and acute severe lung injury was initially regarded as the main insult, and patients underwent the typical treatment developed for ARDS.
T365 60694-61009 Sentence denotes However, more recent evidence from autopsy series revealed that COVID-19 is a systemic disease, in which interstitial pneumonia is associated with extensive microvascular damage, which is not limited to the lungs and leads to fibrin deposition, neutrophils trapping in microvasculature, and arteriolar microthrombi.
T366 61010-61164 Sentence denotes Moreover, cardiovascular involvement has been observed, occasionally leading to myocardial injury and sudden death after weeks from the initial infection.
T367 61165-61336 Sentence denotes These findings are crucial to optimize the treatment of COVID-19 patients, hopefully improving the prognosis (Buja et al., 2020; Carsana et al., 2020; Magro et al., 2020).
T368 61337-61485 Sentence denotes Another determinant of the clinical picture and a negative prognostic factor is an aggressive proinflammatory response of the host to the infection.
T369 61486-61624 Sentence denotes Huang described the clinical features of 41 patients admitted to their Institute in January of 2020 with confirmed COVID-19 and pneumonia.
T370 61625-61723 Sentence denotes In 29% (n = 12) of patients ARDS occurred and in 10% invasive mechanical ventilation was required.
T371 61724-61849 Sentence denotes These patients clearly showed increased production of IL-1β, IFN-γ, IP-10, MCP-1, IL-4, and IL-10 compared to healthy people.
T372 61850-62165 Sentence denotes Moreover, the patients who required access to the intensive care unit had significantly higher levels of proinflammatory cytokines compared to those who did not require intensive care, suggesting that this “cytokine storm” may trigger the development of the most severe forms of the disease (Huang C. et al., 2020).
T373 62166-62284 Sentence denotes The molecular mechanisms involved in the cytokine storm and the role of ACE2 are currently still not fully understood.
T374 62285-62498 Sentence denotes As discussed above, virus binding to the ACE2 is the event that initiates viral replication in susceptible cells, such as alveolar epithelial cells, vascular cells and immune system cells (macrophages, monocytes).
T375 62499-62627 Sentence denotes This has been suggested to trigger the primary inflammatory response, which involves apoptosis and pyroptosis (Fu et al., 2020).
T376 62628-62878 Sentence denotes The apoptosis pattern indices cell death to avoid viral replication in the absence of overt inflammation, whereas, pyroptosis is a violent form of programmed cell death, followed by an inflammatory storm (Cookson and Brennan, 2001; Liu et al., 2016).
T377 62879-63125 Sentence denotes In the standard pyroptosis model, when the pathogen enters the host cell, some specific structures on the pathogen surface (PAMPs–pathogen associated molecular patterns) are identified by pattern recognition receptors (PRRs) on the host membrane.
T378 63126-63571 Sentence denotes One common PRR is NOD-like receptors protein 3 (NLRP3), which forms together with a protein caspase activating protein (ASC or apoptosis-associated speck-like protein containing a caspase recruitment domain) and pro-caspase 1, the inflammasome unit capable of recruiting proinflammatory cytokines and inducing cell lysis with further inflammation signals (Fernandes-Alnemri et al., 2007; Schroder and Tschopp, 2010; Wree et al., 2014; Figure 9).
T379 63572-63679 Sentence denotes FIGURE 9 Possible role of ACE2 in the molecular mechanisms involved in the “cytokine storm” of SARS-CoV-2.
T380 63680-63901 Sentence denotes In the SARS-CoV-2 infection, pyroptosis has been demonstrated to be active in macrophages, being viroporin 3a a trigger for NLRP3 with subsequent production of proinflammatory cytokines, such as IL-1β (Chen et al., 2019).
T381 63902-64040 Sentence denotes In COVID-19 patients, the pyroptosis activation has been indirectly demonstrated by the high serum level of IL-1β (Huang C. et al., 2020).
T382 64041-64228 Sentence denotes Moreover, the severe leucopoenia and lymphopenia, commonly showed in COVID-19 pneumonia and associated with poor prognosis, are likely due to lymphocyte injury by pyroptosis (Yang, 2020).
T383 64229-64354 Sentence denotes Another proposed mechanism that triggers the proinflammatory response to SARS-CoV-2 is ACE/ACE2 imbalance in the RAAS system.
T384 64355-64651 Sentence denotes It has been speculated that when ACE2 is occupied by the virus, its effects in limiting the amount and activity of Ang-II is decreased; Ang-II is consequently increased and it has been reported to induce a proinflammatory effect via the AT1R receptor (Marchesi et al., 2008; Eguchi et al., 2018).
T385 64652-64996 Sentence denotes The Ang-II/AT1R system activates disintegrin and the metalloprotease ADAM 17 (also known as TNFα cleavage enzyme TACE), which lead to the intracellular production of epidermal growth factor ligands (EGFR) and TNFα production, with subsequent stimulation of the transcription factor NF-K B, a pivotal player in proinflammatory cytokines release.
T386 64997-65236 Sentence denotes Additionally, ADAM 17 activation induces the production of the soluble form of IL-6Rα, active on IL-6-STAT3 pathway, which in turn amplifies NF-K B signaling (Murakami et al., 2019; Takimoto-Ohnishi and Murakami, 2019; Palau et al., 2020).
T387 65237-65333 Sentence denotes The convergence on hyperactivation of NF-K B seems to be crucial in inducing the cytokine storm.
T388 65334-65530 Sentence denotes The mechanism is self-feeding, given that NF-K B induces the expression of the angiotensinogen gene, amplifying the Ang-II inflammatory response (Costanzo et al., 2003; Hirano and Murakami, 2020).
T389 65531-65619 Sentence denotes ACE2 shedding is an additional mechanism contributing to inflammation (Fu et al., 2020).
T390 65620-65873 Sentence denotes ACE2 shedding consists in proteolytic cleavage of the protein ectodomain and leads to the release of enzymatically active soluble ACE2 (sACE), whose action is not completely understood, but might enhance the pro-inflammatory response (Guy et al., 2005).
T391 65874-66089 Sentence denotes ADAM 17 and disintegrin are able to shed not only TNFα but also a variety of membrane-anchored enzymes, including ACE2 (Black et al., 1997; Palau et al., 2020), as demonstrated by Lambert in 2005 (Guy et al., 2005).
T392 66090-66406 Sentence denotes In their experiment, human embryonic kidney cells (HEK293) expressing human ACE2 (HEK-ACE2) were treated with phorbol myristate acetate stimulation and the production of a polypeptide of 105 kDa was demonstrated by western blot analysis, suggesting the occurrence of a proteolytic shedding in the ectodomain of ACE2.
T393 66407-66627 Sentence denotes Subsequently, they demonstrated that the cleavage was performed by ADAM17, incubating cells with a specific hydroxamic acid-based metalloproteinase inhibitor, namely TAPI-1 (TNFα protease inhibitor 1) (Guy et al., 2005).
T394 66628-66745 Sentence denotes ACE2 shedding seems to be inducible by specific stimuli produced either by a viral infection or by the immune system.
T395 66746-66859 Sentence denotes Jia et al. (2009) confirmed ACE2 shedding in differentiated primary airway epithelial cells and Calu-3-cell line.
T396 66860-67068 Sentence denotes Furthermore, they demonstrated that the incubation with IL-1β at the dosage of 100 ng/ml and TNF α 100 ng/ml induced ACE2 shedding and sACE release, with a maximum after 18 h of incubation (Jia et al., 2009).
T397 67069-67204 Sentence denotes These findings suggest that an inflammatory response is likely to modulate ACE2 expression and shedding, also during a viral infection.
T398 67205-67389 Sentence denotes Following this data, ADAM17 inhibition was proposed as a possible pharmacological target in SARS-CoV-2, but further studies are needed to evaluate this hypothesis (Palau et al., 2020).
T399 67390-67549 Sentence denotes Other conditions have been assumed to be involved in the susceptibility to SARS-CoV-2 and among them vitamin D deficiency was proposed as a credible candidate.
T400 67550-67711 Sentence denotes The interesting candidate could be identified as a modifiable risk factor (hypovitaminosis D) and a potential tool in COVID-19 prevention or ancillary treatment.
T401 67712-68368 Sentence denotes The rationale has been summarized by Grant et al. in a recent review on the evidence supporting a possible correlation between vitamin D and SARS-CoV-2 risk: (i) the seasonal flare of SARS-CoV-2 which coincides with the nadir of vitamin D levels, (ii) the association between hypovitaminosis D and pulmonary infections together with the demonstrated protective role in acute respiratory infections, in adults (iii) the anti-inflammatory role of vitamin D which could be of benefit against the so called “cytokine storm,” which seems to be a major player in SARS-CoV-2 morbidity and mortality (Martineau et al., 2017; Zhou et al., 2019; Grant et al., 2020).
T402 68370-68398 Sentence denotes ACE2 as a Therapeutic Target
T403 68399-68487 Sentence denotes As evidence builds up, ACE2 rapidly emerged as a specific target for COVID-19 treatment.
T404 68488-68792 Sentence denotes Since this enzyme was identified as the SARS-CoV-2 receptor (Zhou et al., 2020), several approaches to address ACE2 mediated infection have been described (Li Y. et al., 2020; Zhang H. et al., 2020), with the aim to prevent host cell entry and subsequent viral replication, as well as severe lung injury.
T405 68793-68846 Sentence denotes Potential therapeutic approaches include (Figure 10):
T406 68847-68958 Sentence denotes FIGURE 10 Schematic representation of the potential therapeutic approaches to address ACE2 mediated infection.
T407 68959-69163 Sentence denotes Exogenous administration of soluble recombinant human ACE 2 sequesters circulating viral particles, while specific ACE2 blockers bind the receptor, impeding the S-protein interaction with the host target.
T408 69164-69166 Sentence denotes 1.
T409 69168-69182 Sentence denotes ACE2 blockers;
T410 69183-69185 Sentence denotes 2.
T411 69187-69220 Sentence denotes Exogenous administration of ACE2.
T412 69222-69235 Sentence denotes ACE2 Blockers
T413 69236-69486 Sentence denotes Blockade of ACE2 receptor could be achieved through specific antibodies (Li et al., 2003), rationally designed small molecules (Dales et al., 2002; Huentelman et al., 2004; Gross et al., 2020; Pillaiyar et al., 2020) or peptides (Huang et al., 2003).
T414 69487-69675 Sentence denotes Although their efficacy needs to be confirmed, some of these agents are currently available on the market and have been show to effectively block SARS-CoV invasion (Li S.-R. et al., 2020).
T415 69676-70003 Sentence denotes For instance, the small synthetic inhibitor N-(2-aminoethyl)-1aziridine-ethanamine (NAAE) binds ACE2 active site in its closed conformation; this contact triggers the shifting of SARS-CoV S binding residues preventing the molecular interaction with targeted enzyme and the subsequent cell-cell fusion (Huentelman et al., 2004).
T416 70004-70202 Sentence denotes Therefore, although ACE2 catalytic site is distinct from the S-protein-binding domain, NAAE exerts dual inhibitory effects on ACE2 catalytic activity and SARS binding (Adedeji and Sarafianos, 2014).
T417 70203-70499 Sentence denotes However, since a protecting role for ACE2 receptor against virus-induced acute lung injury in infections with SARS coronavirus has not been excluded (Imai et al., 2005; Kuba et al., 2005; Li S.-R. et al., 2020), the choice of ACE2 inhibition as therapeutic approach should be carefully evaluated.
T418 70501-70533 Sentence denotes Exogenous Administration of ACE2
T419 70534-70942 Sentence denotes The administration of a large amount of soluble form of ACE2 could represent an intriguing opportunity, since excessive ACE2 may exert dual functions: (a) competitively bind SARS-CoV-2 to neutralize the virus and/or slow viral entry in the host cell; (b) rescue cellular ACE2 activity, which negatively regulates RAAS and may theoretically exert a protective effect in lung injury (Verdecchia et al., 2020a).
T420 70943-71122 Sentence denotes A pilot clinical study is currently investigating the efficiency of a recombinant human angiotensin-converting enzyme 2 (rhACE2) in patients with COVID-19 (Zhang H. et al., 2020).
T421 71123-71327 Sentence denotes Recombinant human ACE 2, rhACE2 (hrsACE2, APN01, GSK2586881), sequesters circulating viral particles interfering with S-protein binding to its host target, beside its role in regulating the systemic RAAS.
T422 71328-71683 Sentence denotes Taken together, these activities may offer therapeutic benefits in COVID-19 patients, although the large molecular weight of the protein may potentially limit its effects on local RAAS (Gheblawi et al., 2020). rhACE2 has already undergone phase 1 and 2 clinical trials in healthy volunteers and in a small cohort of patients with ARDS (Khan et al., 2017).
T423 71684-71890 Sentence denotes Moreover, it has been demonstrated that rhACE2 can significantly block the early stages of SARS-CoV-2 infections in engineered human blood vessel organoids and human kidney organoids (Monteil et al., 2020).
T424 71891-72052 Sentence denotes In this context, Procko (2020) was able to engineer hACE2 sequences to obtain soluble receptors able to sequester SARS-CoV-2 RBD and inhibit its cell attachment.
T425 72053-72259 Sentence denotes Remarkably, combinatorial mutants enhanced ACE2 binding to SARS-CoV-2 RBD by an order of magnitude, as compared to the wild type receptor form, and targeted ACE2 mutations might provide further improvement.
T426 72260-72489 Sentence denotes Additionally, the availability of ACE2 nanoparticles applied to nose filters, chewing gums, clothes, filters and gloves could be of help in sequestering the virus thus preventing its entry into the host (Aydemir and Ulusu, 2020).
T427 72490-72722 Sentence denotes Prevention virus transmission could represent a more convenient strategy than therapeutic interventions on viral infection, avoiding interference with ACE2 and disturbance of the finely regulated RAAS axis (Aydemir and Ulusu, 2020).
T428 72724-72747 Sentence denotes ACE2 and Other Diseases
T429 72748-72802 Sentence denotes ACE2 is a multiform protein (Feng et al., 2010, 2011).
T430 72803-72993 Sentence denotes As discussed above (section Structure of ACE2) its C-terminal domain is similar to collectrin, a kidney protein involved in amino acids trafficking and insulin secretion (Kuba et al., 2013).
T431 72994-73106 Sentence denotes Alterations in ACE2 have been demonstrated in Hartnup’s disease due to a disturbance in amino acids homeostasis.
T432 73107-73224 Sentence denotes Indeed, ACE2 has been proposed to modulate amino acid transport in bowel and gut microbiome (Hashimoto et al., 2012).
T433 73225-73322 Sentence denotes Moreover, ACE2 participates in the regulation of metabolism, particularly of glucose homeostasis.
T434 73323-73430 Sentence denotes In the pancreas, activation of the ACE2-Ang1-7-MasR pathway improves insulin secretion (Yuan et al., 2013).
T435 73431-73617 Sentence denotes Obesity and high-fat diets cause a reduction in ACE2 expression in the adipose tissue, which in turn results in increased blood pressure (Gupte et al., 2008, 2012; Carsana et al., 2020).
T436 73618-73763 Sentence denotes A role for ACE2 is emerging in Alzheimer disease, since it has been shown that ACE2 can hydrolyse Beta amyloid peptides (Zou et al., 2007, 2013).
T437 73764-73847 Sentence denotes There is also increasing evidence that the RAAS system may be implicated in cancer.
T438 73848-74048 Sentence denotes ACE2 was found to inhibit cancer cell growth, metastasis, and angiogenesis in breast (Yu et al., 2016; Zhang Q. et al., 2019), pancreatic (Zhou et al., 2011), and colon cancer (Bernardi et al., 2012).
T439 74049-74258 Sentence denotes Another study pointed out that hepatocellular carcinoma patients with higher levels of ACE2 had longer survival times, suggesting a positive link between ACE2 expression and better prognosis (Ye et al., 2015).
T440 74259-74425 Sentence denotes Studies on human xenografts in mice clearly indicated that ACE2 inhibited tumor growth by suppressing invasion and angiogenesis in Non-Small Cell Lung Cancer (NSCLC).
T441 74426-74699 Sentence denotes Remarkably, the same group demonstrated that overexpression of ACE2 promotes the expression of E-cadherin at expenses of mesenchymal markers such as vimentin, and thereby inhibits the epithelial-mesenchymal transition in NSCLC models (Feng et al., 2010; Qian et al., 2013).
T442 74700-74906 Sentence denotes The discovery that lung cancer patients that harbor COVID-19 display more severe symptoms (Liang et al., 2020) set out intensive research on the possible connection between malignancies and ACE2 expression.
T443 74907-75024 Sentence denotes A thorough bioinformatics analysis of the TCGA dataset on several kinds of cancer (Chai et al., 2020) has shown that:
T444 75025-75093 Sentence denotes (1) Mutation and amplification of ACE2 gene are frequent in cancer.
T445 75094-75199 Sentence denotes Yet, hot-spot mutation sites were never observed, as ACE2 mutations were distributed across all 18 exons.
T446 75200-75456 Sentence denotes (2) ACE2 transcription was upregulated in six tumors: colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and lung adenocarcinoma (LUAD).
T447 75457-75544 Sentence denotes Interestingly, ACE2 transcription was unchanged in lung squamous cell carcinoma (LUSC).
T448 75545-75689 Sentence denotes (3) ACE2 transcription was downregulated in three tumors: testicular germ cell (TGCT), thyroid carcinoma (THCA), and kidney chromophobe (KICH).
T449 75690-75845 Sentence denotes (4) Changes of ACE2 transcription were epigenetic in nature, as both mutation and copy variation of ACE2 did not correlate with its up- or downregulation.
T450 75846-75950 Sentence denotes (5) In most cases, changes of ACE2 transcription strongly correlated with methylation in ACE2 promoter.
T451 75951-76081 Sentence denotes More specifically, decreased methylation levels correlated with upregulation, whereas increased methylation led to downregulation.
T452 76082-76169 Sentence denotes (6) No prognostic role of ACE2 expression on patient’s survival could be demonstrated.
T453 76170-76290 Sentence denotes These data confirm the remarkable role of methylation in determining the ACE2 expression, as described in paragraph 2.2.
T454 76291-76636 Sentence denotes Interestingly, a second bioinformatics study on Oncomine and TCGA databases gave slightly different results in terms of tumor-associated ACE2 expression changes, but confirmed the role of promoter hypomethylation in KIRP and uterine corpus endometrial carcinoma (UCEC) where ACE2 transcription was significantly upregulated (Yang et al., 2020a).
T455 76638-76648 Sentence denotes Conclusion
T456 76649-76772 Sentence denotes From the structural point of view ACE2 is closely related to ACE, and its discovery was a by-product of ACE investigations.
T457 76773-76887 Sentence denotes However, this macromolecule has soon showed peculiar functional properties and has attracted increasing attention.
T458 76888-77139 Sentence denotes The expression of ACE2 in the heart, kidney and vascular system pointed to a role in the regulation of blood pressure and cardiovascular homeostasis, possibly as a counterbalance to ACE activation, but this hypothesis now appears to be too simplistic.
T459 77140-77338 Sentence denotes Additional functions of ACE2 are strongly suggested by its capability to modulate cytokine metabolism and the inflammatory reaction, as well as by its remarkable expression in the respiratory tract.
T460 77339-77549 Sentence denotes The recent COVID-19 pandemic has put ACE2 in the spotlight, since it has been identified as the initial target of the SARS-Cov and SARS-Cov2 viruses, representing the receptor responsible for cellular adhesion.
T461 77550-77783 Sentence denotes Recent investigations have clarified the molecular details of the interaction of ACE2 with the spike glycoprotein present in this class of coronaviruses, and have partly unraveled the mechanism of protein cleavage and cellular entry.
T462 77784-78082 Sentence denotes ACE2 density on cell surface and ACE2-modulated inflammatory reactions have been suggested to be important determinants of COVID-19 susceptibility and clinical course, while drugs interfering with ACE2 expression, availability and processing are under investigation as potential therapeutic agents.
T463 78083-78289 Sentence denotes However, several crucial issues concerning the link between ACE2 and COVID-19 pathophysiology are still unclear, pointing to the need for focused experimental investigations and prospective clinical trials.
T464 78291-78311 Sentence denotes Author Contributions
T465 78312-78414 Sentence denotes FS, GR, SS, LB, BS, and RB wrote the first draft of the manuscript and prepared the table and figures.
T466 78415-78450 Sentence denotes RZ revised and integrated the text.
T467 78451-78510 Sentence denotes All authors decided upon the general outline of the review.
T468 78512-78532 Sentence denotes Conflict of Interest
T469 78533-78705 Sentence denotes The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
T470 78707-78715 Sentence denotes Funding.
T471 78716-78799 Sentence denotes This work is supported by the PRA 2020-22 to GR, granted by the University of Pisa.
T472 78800-78854 Sentence denotes 1 https://www.preprints.org/manuscript/202003.0295/v1