PMC:7554011 / 9078-9830 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7554011","sourcedb":"PMC","sourceid":"7554011","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7554011","text":"Paediatric biorelevant media representative of infants were freshly prepared for each experiment, as described by Maharaj et al. (20). Infant fasted-state simulated gastric fluid (Pi-FaSSGF, pH 1.6) and fasted-state simulated intestinal fluid (FaSSIF-V2, pH 6.5) or infant fed-state simulated intestinal fluid (Pi-FeSSIF, pH 5.8) were used. Both fasted and fed intestinal state were simulated since the prandial state of the infant patients in the in vivo studies was not reported, and in order to investigate if medicine co-administration with a vehicle would induce a food effect in the infant. Double concentrated simulated intestinal fluids were prepared for the two-stage dissolution studies performed (“Biorelevant In Vitro Dissolution Studies”).","tracks":[{"project":"2_test","denotations":[{"id":"33051713-26220249-26790","span":{"begin":130,"end":132},"obj":"26220249"}],"attributes":[{"subj":"33051713-26220249-26790","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#e093ec","default":true}]}]}}