PMC:7554011 / 28206-29240 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7554011","sourcedb":"PMC","sourceid":"7554011","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7554011","text":"Results from this study suggest that the in vivo studies were likely performed in the fed state (as the prandial state of the infants is not evident) or that the practice of medicine co-administration with food and drinks might trigger fed-state conditions in vivo. The biorelevant in vitro dissolution test (fasted-state gastric conditions followed by fed-state intestinal conditions) using milk gives the best prediction of the in vivo product performance for infants of all subgroups. This is likely related to the high solubility of montelukast in this vehicle and its carbohydrate, protein and fat content which is similar to that observed in the stomach after administration of meals. Further investigations would be helpful to confirm and further optimise the dissolution testing parameters for a predictive, physiologically relevant methodology (1,2). A detailed characterisation of paediatric GI contents of different age groups in vivo would be valuable for further development of these paediatric biopharmaceutical methods.","tracks":[{"project":"2_test","denotations":[{"id":"33051713-22547350-26825","span":{"begin":854,"end":855},"obj":"22547350"},{"id":"33051713-26721731-26826","span":{"begin":856,"end":857},"obj":"26721731"}],"attributes":[{"subj":"33051713-22547350-26825","pred":"source","obj":"2_test"},{"subj":"33051713-26721731-26826","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93ecc5","default":true}]}]}}