PMC:7553377 / 24270-26028
Annnotations
{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7553377","sourcedb":"PMC","sourceid":"7553377","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7553377","text":"In this study, we aimed to monitor the changes in clinical, laboratory features, and L/S of COVID-19 patients during the course of disease. Many patients who are hospitalized due to COVID-19 get multiple chest CT scans depending on the clinical progression. There are a few series in the literature that have demonstrated how evolution of thoracic imaging findings happen [2, 11, 20]. In spite of the commonly observed chest imaging findings associated with COVID-19, reports of abdominal imaging findings are limited. A study has demonstrated that bowel involvement and cholestasis are the most common abdominal imaging findings in COVID-19 patients [23]. It has been reported that 16–53% of patients with COVID-19 have abnormal liver function tests during disease progression [24–26]. However, how the changes in liver parenchyma will be seen on imaging is not clear. It is known that changes of hepatic attenuation may be observed in some diffuse liver diseases and L/S is commonly used to assess the presence of liver fat [14, 15, 17]. In our study, we hypothesized the use of L/S to evaluate the changes in hepatic attenuation between the two consecutive scans and investigated if it may correlate with abnormal liver function tests. We found that L/S at follow-up was significantly different between the progressive and non-progressive groups. As the lung CT scores increased, L/S tended to decrease on follow-up CTs. Similarly, in our study, liver function tests did not differ between the two groups of patients at hospital admission however, the increase in ALT values at follow-up was significant in patients with progressed lung CT scores (p = 0.02). Additionally, in patients with decreased L/S, ALT levels were elevated at follow-up (p = 0.004).","tracks":[{"project":"2_test","denotations":[{"id":"33051758-32101510-31259","span":{"begin":373,"end":374},"obj":"32101510"},{"id":"33051758-32505599-31260","span":{"begin":376,"end":378},"obj":"32505599"},{"id":"33051758-32053470-31261","span":{"begin":380,"end":382},"obj":"32053470"},{"id":"33051758-32391742-31262","span":{"begin":652,"end":654},"obj":"32391742"},{"id":"33051758-32105637-31263","span":{"begin":779,"end":781},"obj":"32105637"},{"id":"33051758-32075786-31263","span":{"begin":779,"end":781},"obj":"32075786"},{"id":"33051758-32283325-31263","span":{"begin":779,"end":781},"obj":"32283325"},{"id":"33051758-17449775-31264","span":{"begin":1027,"end":1029},"obj":"17449775"},{"id":"33051758-19755595-31265","span":{"begin":1031,"end":1033},"obj":"19755595"},{"id":"33051758-15599315-31266","span":{"begin":1035,"end":1037},"obj":"15599315"}],"attributes":[{"subj":"33051758-32101510-31259","pred":"source","obj":"2_test"},{"subj":"33051758-32505599-31260","pred":"source","obj":"2_test"},{"subj":"33051758-32053470-31261","pred":"source","obj":"2_test"},{"subj":"33051758-32391742-31262","pred":"source","obj":"2_test"},{"subj":"33051758-32105637-31263","pred":"source","obj":"2_test"},{"subj":"33051758-32075786-31263","pred":"source","obj":"2_test"},{"subj":"33051758-32283325-31263","pred":"source","obj":"2_test"},{"subj":"33051758-17449775-31264","pred":"source","obj":"2_test"},{"subj":"33051758-19755595-31265","pred":"source","obj":"2_test"},{"subj":"33051758-15599315-31266","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#d7ec93","default":true}]}]}}