PMC:7553377 / 20124-23183 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7553377","sourcedb":"PMC","sourceid":"7553377","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7553377","text":"L/S and CT scores\nThe median time interval from the onset of symptoms of the disease to the first chest CT scan was 2 days (range 1–4 days). The median time interval between the first and second chest CT scans for the study population were 8 days (range 2–29 days). The median time interval between the first and second chest CT scans were 12 days (range 4–26) and 7.5 days (range 2–29) for the non-progressive group and progressive group, respectively. Table 4 shows lung CT scores, L/S, and liver densities on CT of the two groups of patients for the two time points. The mean L/S of the progressive group was lower than that of the non-progressive group at hospital admission but there was no significant difference between the two groups (p = 0.547). However, L/S was found to be significantly different between the two groups of patients at follow-up (p = 0.009) (Fig. 3). For the intragroup analysis, there was a significant change in L/S in patients with increased lung CT score (p = 0.014). In the progressive group, as the median lung CT score was increased from 6.5 (range 0–14) to 12 (range 5–24) in two consecutive scans, the mean L/S was decreased from 1.13 ± 0.3 to 1.02 ± 0.23. For the non-progressive group, L/S was elevated in the second CT scan, however the change in L/S was not statistically significant for the intragroup analysis (p = 0.465). The change between the baseline and follow-up L/S was found to be statistically significant for the progressive group (p = 0.028).\nTable 4 Liver-to-spleen ratio of the two groups of COVID-19 patients\nNon-progressive group (n = 7) Progressive group (n = 20)\nAt hospital admission Follow-up At hospital admission Follow-up\nCT score 1 (0–19) 1 (0–19) 6.5 (0–14) 12 (5–24)\nL/S 1.21 ± 0.29a 1.25 ± 0.29a 1.13 ± 0.3b 1.02 ± 0.23b\nLiver density (HU) 52.52 ± 12.4\n56.67 (30.33–65.33) 55.19 ± 12.83\n58 (38–73.67) 52.6 ± 12.8\n55.5 (17.33–65) 49.87 ± 11.09\n52 (17.33–66)\nData are median (minimum–maximum) and mean ± standard deviation. L/S liver-to-spleen ratio\naIn the non-progressive group, there was no significant difference between the comparison of L/S values that were obtained at hospital admission and follow-up (p = 0.465) (paired t-test)\nbIn the progressive group, there was a significant difference between the comparison of L/S values that were obtained at hospital admission and follow-up (p = 0.014) (paired t-test)\nThere was no significant difference of L/S between the two groups at hospital admission (p = 0.547) (independent samples t-test)\nFollow-up L/S was significantly different between the two groups (p = 0.009) (covariance analysis)\nThe change between the baseline and follow-up L/S was statistically significant for the progressive group (p = 0.028) (independent samples t-test)\nFig. 3 66-year old woman with COVID-19. (a) CT lung score was 0 at hospital admission. (b) Liver-to-spleen ratio at hospital admission was calculated as 1.2. (c) CT lung score was 12 at follow-up CT scan which was obtained 10 days later. (d) Liver-to-spleen ratio at follow-up was calculated as 0.82","divisions":[{"label":"title","span":{"begin":0,"end":17}},{"label":"table-wrap","span":{"begin":1496,"end":2759}},{"label":"label","span":{"begin":1496,"end":1503}},{"label":"caption","span":{"begin":1504,"end":1564}},{"label":"p","span":{"begin":1504,"end":1564}},{"label":"table","span":{"begin":1565,"end":1924}},{"label":"tr","span":{"begin":1565,"end":1621}},{"label":"th","span":{"begin":1565,"end":1594}},{"label":"th","span":{"begin":1595,"end":1621}},{"label":"tr","span":{"begin":1622,"end":1685}},{"label":"th","span":{"begin":1622,"end":1643}},{"label":"th","span":{"begin":1644,"end":1653}},{"label":"th","span":{"begin":1654,"end":1675}},{"label":"th","span":{"begin":1676,"end":1685}},{"label":"tr","span":{"begin":1686,"end":1733}},{"label":"td","span":{"begin":1686,"end":1694}},{"label":"td","span":{"begin":1695,"end":1703}},{"label":"td","span":{"begin":1704,"end":1712}},{"label":"td","span":{"begin":1713,"end":1723}},{"label":"td","span":{"begin":1724,"end":1733}},{"label":"tr","span":{"begin":1734,"end":1788}},{"label":"td","span":{"begin":1734,"end":1737}},{"label":"td","span":{"begin":1738,"end":1750}},{"label":"td","span":{"begin":1751,"end":1763}},{"label":"td","span":{"begin":1764,"end":1775}},{"label":"td","span":{"begin":1776,"end":1788}},{"label":"tr","span":{"begin":1789,"end":1924}},{"label":"td","span":{"begin":1789,"end":1807}},{"label":"td","span":{"begin":1808,"end":1840}},{"label":"p","span":{"begin":1808,"end":1820}},{"label":"p","span":{"begin":1821,"end":1840}},{"label":"td","span":{"begin":1841,"end":1868}},{"label":"p","span":{"begin":1841,"end":1854}},{"label":"p","span":{"begin":1855,"end":1868}},{"label":"td","span":{"begin":1869,"end":1896}},{"label":"p","span":{"begin":1869,"end":1880}},{"label":"p","span":{"begin":1881,"end":1896}},{"label":"td","span":{"begin":1897,"end":1924}},{"label":"p","span":{"begin":1897,"end":1910}},{"label":"p","span":{"begin":1911,"end":1924}},{"label":"table-wrap-foot","span":{"begin":1925,"end":2759}},{"label":"p","span":{"begin":1925,"end":2015}},{"label":"p","span":{"begin":2016,"end":2202}},{"label":"p","span":{"begin":2203,"end":2384}},{"label":"p","span":{"begin":2385,"end":2513}},{"label":"p","span":{"begin":2514,"end":2612}},{"label":"p","span":{"begin":2613,"end":2759}},{"label":"label","span":{"begin":2760,"end":2766}}],"tracks":[]}