PMC:7553147 / 19415-19885 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T26","span":{"begin":104,"end":111},"obj":"Body_part"},{"id":"T27","span":{"begin":206,"end":213},"obj":"Body_part"}],"attributes":[{"id":"A26","pred":"fma_id","subj":"T26","obj":"http://purl.org/sig/ont/fma/fma82761"},{"id":"A27","pred":"fma_id","subj":"T27","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"In the following, we describe the analysis of SARS-CoV-2 spike stabilized in the prefusion state by two proline substitutions in S2 (S-2P). We will objectively demonstrate that the flexibility of the spike protein should be understood as a quasi-continuum of conformations, so that when performing a structural analysis on this specimen special care has to be paid to the image-processing workflows, since they may directly impact on the interpretability of the results."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T16","span":{"begin":46,"end":54},"obj":"Disease"}],"attributes":[{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"}],"text":"In the following, we describe the analysis of SARS-CoV-2 spike stabilized in the prefusion state by two proline substitutions in S2 (S-2P). We will objectively demonstrate that the flexibility of the spike protein should be understood as a quasi-continuum of conformations, so that when performing a structural analysis on this specimen special care has to be paid to the image-processing workflows, since they may directly impact on the interpretability of the results."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T107","span":{"begin":129,"end":131},"obj":"http://purl.obolibrary.org/obo/CLO_0008922"},{"id":"T108","span":{"begin":129,"end":131},"obj":"http://purl.obolibrary.org/obo/CLO_0050052"},{"id":"T109","span":{"begin":148,"end":159},"obj":"http://purl.obolibrary.org/obo/BFO_0000030"},{"id":"T110","span":{"begin":238,"end":239},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T111","span":{"begin":298,"end":299},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T112","span":{"begin":350,"end":353},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"In the following, we describe the analysis of SARS-CoV-2 spike stabilized in the prefusion state by two proline substitutions in S2 (S-2P). We will objectively demonstrate that the flexibility of the spike protein should be understood as a quasi-continuum of conformations, so that when performing a structural analysis on this specimen special care has to be paid to the image-processing workflows, since they may directly impact on the interpretability of the results."}

{"project":"LitCovid-sentences","denotations":[{"id":"T150","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"T151","span":{"begin":140,"end":470},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In the following, we describe the analysis of SARS-CoV-2 spike stabilized in the prefusion state by two proline substitutions in S2 (S-2P). We will objectively demonstrate that the flexibility of the spike protein should be understood as a quasi-continuum of conformations, so that when performing a structural analysis on this specimen special care has to be paid to the image-processing workflows, since they may directly impact on the interpretability of the results."}

{"project":"LitCovid-PubTator","denotations":[{"id":"113","span":{"begin":133,"end":137},"obj":"Gene"},{"id":"114","span":{"begin":200,"end":205},"obj":"Gene"},{"id":"115","span":{"begin":57,"end":62},"obj":"Gene"},{"id":"116","span":{"begin":46,"end":56},"obj":"Species"},{"id":"117","span":{"begin":104,"end":111},"obj":"Chemical"}],"attributes":[{"id":"A113","pred":"tao:has_database_id","subj":"113","obj":"Gene:51360"},{"id":"A114","pred":"tao:has_database_id","subj":"114","obj":"Gene:43740568"},{"id":"A115","pred":"tao:has_database_id","subj":"115","obj":"Gene:43740568"},{"id":"A116","pred":"tao:has_database_id","subj":"116","obj":"Tax:2697049"},{"id":"A117","pred":"tao:has_database_id","subj":"117","obj":"MESH:D011392"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In the following, we describe the analysis of SARS-CoV-2 spike stabilized in the prefusion state by two proline substitutions in S2 (S-2P). We will objectively demonstrate that the flexibility of the spike protein should be understood as a quasi-continuum of conformations, so that when performing a structural analysis on this specimen special care has to be paid to the image-processing workflows, since they may directly impact on the interpretability of the results."}