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PMC:7551987 / 146-1860 JSONTXT

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LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
4 907-954 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
5 956-966 Species denotes SARS-CoV-2 Tax:2697049
6 25-43 Disease denotes parasite virulence MESH:D010272
7 681-700 Disease denotes infectious diseases MESH:D003141

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T3 0-136 Sentence denotes The relationship between parasite virulence and transmission is a pillar of evolutionary theory that has implications for public health.
T4 137-316 Sentence denotes Part of this canon involves the idea that virulence and free-living survival (a key component of transmission) may have different relationships in different host–parasite systems.
T5 317-522 Sentence denotes Most examinations of the evolution of virulence-transmission relationships—Theoretical or empirical in nature—Tend to focus on the evolution of virulence, with transmission being a secondary consideration.
T6 523-701 Sentence denotes Even within transmission studies, the focus on free-living survival is a smaller subset, though recent studies have examined its importance in the ecology of infectious diseases.
T7 702-835 Sentence denotes Few studies have examined the epidemic-scale consequences of variation in survival across different virulence–survival relationships.
T8 836-1115 Sentence denotes In this study, we utilize a mathematical model motivated by aspects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) natural history to investigate how evolutionary changes in survival may influence several aspects of disease dynamics at the epidemiological scale.
T9 1116-1434 Sentence denotes Across virulence–survival relationships (where these traits are either positively or negatively correlated), we found that small changes (5% above and below the nominal value) in survival can have a meaningful effect on certain outbreak features, including R0, and on the size of the infectious peak in the population.
T10 1435-1714 Sentence denotes These results highlight the importance of properly understanding the mechanistic relationship between virulence and parasite survival, as the evolution of increased survival across different relationships with virulence may have considerably different epidemiological signatures.