PMC:7546716 / 8711-9246 JSONTXT

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{"project":"LitCovid-PubTator","denotations":[{"id":"323","span":{"begin":5,"end":10},"obj":"Gene"},{"id":"324","span":{"begin":12,"end":16},"obj":"Gene"},{"id":"325","span":{"begin":22,"end":26},"obj":"Gene"},{"id":"326","span":{"begin":34,"end":39},"obj":"Gene"},{"id":"327","span":{"begin":84,"end":88},"obj":"Gene"},{"id":"328","span":{"begin":133,"end":137},"obj":"Gene"},{"id":"329","span":{"begin":142,"end":146},"obj":"Gene"},{"id":"330","span":{"begin":183,"end":188},"obj":"Gene"},{"id":"331","span":{"begin":193,"end":199},"obj":"Gene"},{"id":"332","span":{"begin":210,"end":216},"obj":"Gene"},{"id":"333","span":{"begin":450,"end":474},"obj":"Gene"},{"id":"342","span":{"begin":362,"end":367},"obj":"Chemical"}],"attributes":[{"id":"A323","pred":"tao:has_database_id","subj":"323","obj":"Gene:51561"},{"id":"A324","pred":"tao:has_database_id","subj":"324","obj":"Gene:3569"},{"id":"A325","pred":"tao:has_database_id","subj":"325","obj":"Gene:3574"},{"id":"A326","pred":"tao:has_database_id","subj":"326","obj":"Gene:6774"},{"id":"A327","pred":"tao:has_database_id","subj":"327","obj":"Gene:729230"},{"id":"A328","pred":"tao:has_database_id","subj":"328","obj":"Gene:6347"},{"id":"A329","pred":"tao:has_database_id","subj":"329","obj":"Gene:6355"},{"id":"A330","pred":"tao:has_database_id","subj":"330","obj":"Gene:3605"},{"id":"A331","pred":"tao:has_database_id","subj":"331","obj":"Gene:1437"},{"id":"A332","pred":"tao:has_database_id","subj":"332","obj":"Gene:1437"},{"id":"A333","pred":"tao:has_database_id","subj":"333","obj":"Gene:55278"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF. In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages. CCR=C-C motif chemokine receptor. CCL=C-C motif chemokine ligand. CXCL=C-X-C motif chemokine ligand. CXCR=C-X-C chemokine receptor. Foxp=forkhead box protein. GATA=GATA-binding factor. GM-CSF=granulocyte-macrophage colony-stimulating factor. IL"}