PMC:7546716 / 7844-8383
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7546716","sourcedb":"PMC","sourceid":"7546716","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7546716","text":" T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10. IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells. Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages. In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion t","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T120","span":{"begin":3,"end":8},"obj":"Body_part"},{"id":"T121","span":{"begin":86,"end":91},"obj":"Body_part"},{"id":"T122","span":{"begin":113,"end":115},"obj":"Body_part"},{"id":"T123","span":{"begin":290,"end":295},"obj":"Body_part"},{"id":"T124","span":{"begin":394,"end":405},"obj":"Body_part"},{"id":"T125","span":{"begin":436,"end":438},"obj":"Body_part"},{"id":"T126","span":{"begin":454,"end":458},"obj":"Body_part"},{"id":"T127","span":{"begin":454,"end":456},"obj":"Body_part"},{"id":"T128","span":{"begin":463,"end":465},"obj":"Body_part"},{"id":"T129","span":{"begin":480,"end":495},"obj":"Body_part"},{"id":"T130","span":{"begin":490,"end":495},"obj":"Body_part"},{"id":"T131","span":{"begin":523,"end":527},"obj":"Body_part"}],"attributes":[{"id":"A120","pred":"fma_id","subj":"T120","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A121","pred":"fma_id","subj":"T121","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A122","pred":"fma_id","subj":"T122","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A123","pred":"fma_id","subj":"T123","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A124","pred":"fma_id","subj":"T124","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A125","pred":"fma_id","subj":"T125","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A126","pred":"fma_id","subj":"T126","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A129","pred":"fma_id","subj":"T129","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A130","pred":"fma_id","subj":"T130","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A131","pred":"fma_id","subj":"T131","obj":"http://purl.org/sig/ont/fma/fma68646"},{"subj":"T120","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T121","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T122","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T123","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T124","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T125","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T126","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T129","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T130","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T131","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T62","span":{"begin":426,"end":434},"obj":"Disease"}],"attributes":[{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T62","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T107","span":{"begin":1,"end":8},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T108","span":{"begin":86,"end":91},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T109","span":{"begin":143,"end":168},"obj":"http://purl.obolibrary.org/obo/PR_000001944"},{"id":"T110","span":{"begin":288,"end":295},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T111","span":{"begin":454,"end":458},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T112","span":{"begin":480,"end":495},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T113","span":{"begin":521,"end":527},"obj":"http://purl.obolibrary.org/obo/CL_0000084"}],"attributes":[{"subj":"T107","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T108","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T109","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T110","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T111","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T112","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T113","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T92","span":{"begin":95,"end":100},"obj":"Chemical"},{"id":"T93","span":{"begin":105,"end":111},"obj":"Chemical"},{"id":"T94","span":{"begin":113,"end":115},"obj":"Chemical"},{"id":"T96","span":{"begin":374,"end":379},"obj":"Chemical"},{"id":"T97","span":{"begin":384,"end":390},"obj":"Chemical"},{"id":"T98","span":{"begin":436,"end":438},"obj":"Chemical"},{"id":"T100","span":{"begin":454,"end":456},"obj":"Chemical"},{"id":"T102","span":{"begin":463,"end":465},"obj":"Chemical"}],"attributes":[{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_138154"},{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A95","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_138154"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A99","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A101","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A103","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T92","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T93","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T94","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T96","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T97","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T98","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T100","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T102","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T18","span":{"begin":143,"end":163},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T19","span":{"begin":143,"end":156},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T20","span":{"begin":523,"end":537},"obj":"http://purl.obolibrary.org/obo/GO_0016049"}],"attributes":[{"subj":"T18","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T28","span":{"begin":113,"end":296},"obj":"Sentence"},{"id":"T29","span":{"begin":297,"end":406},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T28","pred":"source","obj":"LitCovid-sentences"},{"subj":"T29","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"302","span":{"begin":55,"end":60},"obj":"Gene"},{"id":"303","span":{"begin":95,"end":100},"obj":"Gene"},{"id":"304","span":{"begin":105,"end":111},"obj":"Gene"},{"id":"305","span":{"begin":113,"end":117},"obj":"Gene"},{"id":"306","span":{"begin":164,"end":168},"obj":"Gene"},{"id":"307","span":{"begin":231,"end":235},"obj":"Gene"},{"id":"308","span":{"begin":339,"end":343},"obj":"Gene"},{"id":"309","span":{"begin":374,"end":379},"obj":"Gene"},{"id":"310","span":{"begin":384,"end":390},"obj":"Gene"},{"id":"311","span":{"begin":436,"end":441},"obj":"Gene"},{"id":"312","span":{"begin":454,"end":458},"obj":"Gene"},{"id":"313","span":{"begin":463,"end":467},"obj":"Gene"},{"id":"343","span":{"begin":426,"end":434},"obj":"Disease"}],"attributes":[{"id":"A302","pred":"tao:has_database_id","subj":"302","obj":"Gene:2833"},{"id":"A303","pred":"tao:has_database_id","subj":"303","obj":"Gene:4283"},{"id":"A304","pred":"tao:has_database_id","subj":"304","obj":"Gene:3627"},{"id":"A305","pred":"tao:has_database_id","subj":"305","obj":"Gene:3578"},{"id":"A306","pred":"tao:has_database_id","subj":"306","obj":"Gene:6688"},{"id":"A307","pred":"tao:has_database_id","subj":"307","obj":"Gene:7039"},{"id":"A308","pred":"tao:has_database_id","subj":"308","obj":"Gene:3458"},{"id":"A309","pred":"tao:has_database_id","subj":"309","obj":"Gene:4283"},{"id":"A310","pred":"tao:has_database_id","subj":"310","obj":"Gene:3627"},{"id":"A311","pred":"tao:has_database_id","subj":"311","obj":"Gene:90865"},{"id":"A312","pred":"tao:has_database_id","subj":"312","obj":"Gene:3558"},{"id":"A313","pred":"tao:has_database_id","subj":"313","obj":"Gene:3574"},{"id":"A343","pred":"tao:has_database_id","subj":"343","obj":"MESH:C000657245"},{"subj":"302","pred":"source","obj":"LitCovid-PubTator"},{"subj":"303","pred":"source","obj":"LitCovid-PubTator"},{"subj":"304","pred":"source","obj":"LitCovid-PubTator"},{"subj":"305","pred":"source","obj":"LitCovid-PubTator"},{"subj":"306","pred":"source","obj":"LitCovid-PubTator"},{"subj":"307","pred":"source","obj":"LitCovid-PubTator"},{"subj":"308","pred":"source","obj":"LitCovid-PubTator"},{"subj":"309","pred":"source","obj":"LitCovid-PubTator"},{"subj":"310","pred":"source","obj":"LitCovid-PubTator"},{"subj":"311","pred":"source","obj":"LitCovid-PubTator"},{"subj":"312","pred":"source","obj":"LitCovid-PubTator"},{"subj":"313","pred":"source","obj":"LitCovid-PubTator"},{"subj":"343","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ec93dd","default":true},{"id":"LitCovid-PD-MONDO","color":"#93ece1"},{"id":"LitCovid-PD-CLO","color":"#ecc793"},{"id":"LitCovid-PD-CHEBI","color":"#ad93ec"},{"id":"LitCovid-PD-GO-BP","color":"#93ec93"},{"id":"LitCovid-sentences","color":"#ec93ac"},{"id":"LitCovid-PubTator","color":"#93c6ec"}]}]}}