PMC:7546716 / 7433-9661 JSONTXT

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    LitCovid-PD-FMA-UBERON

    {"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T109","span":{"begin":11,"end":15},"obj":"Body_part"},{"id":"T110","span":{"begin":41,"end":43},"obj":"Body_part"},{"id":"T111","span":{"begin":75,"end":80},"obj":"Body_part"},{"id":"T112","span":{"begin":138,"end":142},"obj":"Body_part"},{"id":"T113","span":{"begin":138,"end":140},"obj":"Body_part"},{"id":"T114","span":{"begin":157,"end":172},"obj":"Body_part"},{"id":"T115","span":{"begin":167,"end":172},"obj":"Body_part"},{"id":"T116","span":{"begin":215,"end":217},"obj":"Body_part"},{"id":"T117","span":{"begin":308,"end":313},"obj":"Body_part"},{"id":"T118","span":{"begin":345,"end":347},"obj":"Body_part"},{"id":"T119","span":{"begin":351,"end":353},"obj":"Body_part"},{"id":"T120","span":{"begin":414,"end":419},"obj":"Body_part"},{"id":"T121","span":{"begin":497,"end":502},"obj":"Body_part"},{"id":"T122","span":{"begin":524,"end":526},"obj":"Body_part"},{"id":"T123","span":{"begin":701,"end":706},"obj":"Body_part"},{"id":"T124","span":{"begin":805,"end":816},"obj":"Body_part"},{"id":"T125","span":{"begin":847,"end":849},"obj":"Body_part"},{"id":"T126","span":{"begin":865,"end":869},"obj":"Body_part"},{"id":"T127","span":{"begin":865,"end":867},"obj":"Body_part"},{"id":"T128","span":{"begin":874,"end":876},"obj":"Body_part"},{"id":"T129","span":{"begin":891,"end":906},"obj":"Body_part"},{"id":"T130","span":{"begin":901,"end":906},"obj":"Body_part"},{"id":"T131","span":{"begin":934,"end":938},"obj":"Body_part"},{"id":"T132","span":{"begin":1008,"end":1011},"obj":"Body_part"},{"id":"T133","span":{"begin":1022,"end":1036},"obj":"Body_part"},{"id":"T134","span":{"begin":1031,"end":1036},"obj":"Body_part"},{"id":"T135","span":{"begin":1192,"end":1197},"obj":"Body_part"},{"id":"T136","span":{"begin":1215,"end":1224},"obj":"Body_part"},{"id":"T137","span":{"begin":1225,"end":1236},"obj":"Body_part"},{"id":"T138","span":{"begin":1252,"end":1256},"obj":"Body_part"},{"id":"T139","span":{"begin":1252,"end":1254},"obj":"Body_part"},{"id":"T140","span":{"begin":1259,"end":1261},"obj":"Body_part"},{"id":"T141","span":{"begin":1270,"end":1272},"obj":"Body_part"},{"id":"T142","span":{"begin":1276,"end":1280},"obj":"Body_part"},{"id":"T143","span":{"begin":1276,"end":1278},"obj":"Body_part"},{"id":"T144","span":{"begin":1283,"end":1285},"obj":"Body_part"},{"id":"T145","span":{"begin":1290,"end":1292},"obj":"Body_part"},{"id":"T146","span":{"begin":1300,"end":1302},"obj":"Body_part"},{"id":"T147","span":{"begin":1370,"end":1375},"obj":"Body_part"},{"id":"T148","span":{"begin":1402,"end":1407},"obj":"Body_part"},{"id":"T149","span":{"begin":1445,"end":1450},"obj":"Body_part"},{"id":"T150","span":{"begin":1461,"end":1463},"obj":"Body_part"},{"id":"T151","span":{"begin":1474,"end":1477},"obj":"Body_part"},{"id":"T152","span":{"begin":1491,"end":1494},"obj":"Body_part"},{"id":"T153","span":{"begin":1546,"end":1555},"obj":"Body_part"},{"id":"T154","span":{"begin":1556,"end":1567},"obj":"Body_part"},{"id":"T155","span":{"begin":1583,"end":1592},"obj":"Body_part"},{"id":"T156","span":{"begin":1617,"end":1626},"obj":"Body_part"},{"id":"T157","span":{"begin":1652,"end":1661},"obj":"Body_part"},{"id":"T158","span":{"begin":1681,"end":1690},"obj":"Body_part"},{"id":"T159","span":{"begin":1719,"end":1726},"obj":"Body_part"},{"id":"T160","span":{"begin":1757,"end":1760},"obj":"Body_part"},{"id":"T161","span":{"begin":1761,"end":1772},"obj":"Body_part"},{"id":"T162","span":{"begin":1773,"end":1783},"obj":"Body_part"},{"id":"T163","span":{"begin":1811,"end":1813},"obj":"Body_part"},{"id":"T164","span":{"begin":1814,"end":1825},"obj":"Body_part"},{"id":"T165","span":{"begin":1855,"end":1859},"obj":"Body_part"},{"id":"T166","span":{"begin":1908,"end":1915},"obj":"Body_part"},{"id":"T167","span":{"begin":1991,"end":1998},"obj":"Body_part"},{"id":"T168","span":{"begin":2210,"end":2227},"obj":"Body_part"},{"id":"T169","span":{"begin":2223,"end":2227},"obj":"Body_part"}],"attributes":[{"id":"A109","pred":"fma_id","subj":"T109","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A110","pred":"fma_id","subj":"T110","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A111","pred":"fma_id","subj":"T111","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A112","pred":"fma_id","subj":"T112","obj":"http://purl.org/sig/ont/fma/fma84051"},{"id":"A113","pred":"fma_id","subj":"T113","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A114","pred":"fma_id","subj":"T114","obj":"http://purl.org/sig/ont/fma/fma273565"},{"id":"A115","pred":"fma_id","subj":"T115","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A116","pred":"fma_id","subj":"T116","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A117","pred":"fma_id","subj":"T117","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A118","pred":"fma_id","subj":"T118","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A119","pred":"fma_id","subj":"T119","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A120","pred":"fma_id","subj":"T120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1 T-cell polarisation in COVID-19\nIL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs. IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9. IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10. IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells. Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages. In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells. At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6. IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF. In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages. CCR=C-C motif chemokine receptor. CCL=C-C motif chemokine ligand. CXCL=C-X-C motif chemokine ligand. CXCR=C-X-C chemokine receptor. Foxp=forkhead box protein. GATA=GATA-binding factor. GM-CSF=granulocyte-macrophage colony-stimulating factor. IL=interleukin. ILC2=type 2 innate lymphoid cell. MyD88=myeloid differentiation primary response protein. NF-κB=nuclear factor-kappa B. NLRP=NACHT, LRR, and PYD domains-containing protein. PU.1=transcription factor PU.1. RORC=nuclear receptor ROR-gamma. ST2=ST2 receptor. STAT=signal transducer and transcription activator. TGF=transforming growth factor. Th=T-helper. TLR=toll-like receptors. Treg=regulatory T cell."}

    LitCovid-PD-MONDO

    {"project":"LitCovid-PD-MONDO","denotations":[{"id":"T61","span":{"begin":32,"end":40},"obj":"Disease"},{"id":"T62","span":{"begin":837,"end":845},"obj":"Disease"},{"id":"T63","span":{"begin":1569,"end":1576},"obj":"Disease"}],"attributes":[{"id":"A61","pred":"mondo_id","subj":"T61","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A62","pred":"mondo_id","subj":"T62","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A63","pred":"mondo_id","subj":"T63","obj":"http://purl.obolibrary.org/obo/MONDO_0007763"}],"text":"Figure 1 T-cell polarisation in COVID-19\nIL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs. IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9. IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10. IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells. Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages. In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells. At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6. IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF. In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages. CCR=C-C motif chemokine receptor. CCL=C-C motif chemokine ligand. CXCL=C-X-C motif chemokine ligand. CXCR=C-X-C chemokine receptor. Foxp=forkhead box protein. GATA=GATA-binding factor. GM-CSF=granulocyte-macrophage colony-stimulating factor. IL=interleukin. ILC2=type 2 innate lymphoid cell. MyD88=myeloid differentiation primary response protein. NF-κB=nuclear factor-kappa B. NLRP=NACHT, LRR, and PYD domains-containing protein. PU.1=transcription factor PU.1. RORC=nuclear receptor ROR-gamma. ST2=ST2 receptor. STAT=signal transducer and transcription activator. TGF=transforming growth factor. Th=T-helper. TLR=toll-like receptors. Treg=regulatory T cell."}

    LitCovid-PD-CLO

    {"project":"LitCovid-PD-CLO","denotations":[{"id":"T96","span":{"begin":9,"end":15},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T97","span":{"begin":61,"end":66},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T98","span":{"begin":75,"end":80},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T99","span":{"begin":107,"end":112},"obj":"http://purl.obolibrary.org/obo/CLO_0053477"},{"id":"T100","span":{"begin":113,"end":118},"obj":"http://purl.obolibrary.org/obo/PR_000001350"},{"id":"T101","span":{"begin":120,"end":125},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T102","span":{"begin":138,"end":142},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T103","span":{"begin":157,"end":172},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T104","span":{"begin":208,"end":213},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T105","span":{"begin":284,"end":287},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T106","span":{"begin":308,"end":313},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T107","span":{"begin":412,"end":419},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T108","span":{"begin":497,"end":502},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T109","span":{"begin":554,"end":579},"obj":"http://purl.obolibrary.org/obo/PR_000001944"},{"id":"T110","span":{"begin":699,"end":706},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T111","span":{"begin":865,"end":869},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T112","span":{"begin":891,"end":906},"obj":"http://purl.obolibrary.org/obo/CL_0000451"},{"id":"T113","span":{"begin":932,"end":938},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T114","span":{"begin":1022,"end":1036},"obj":"http://purl.obolibrary.org/obo/CL_0000912"},{"id":"T115","span":{"begin":1078,"end":1088},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T116","span":{"begin":1114,"end":1115},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T117","span":{"begin":1128,"end":1138},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T118","span":{"begin":1178,"end":1183},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T119","span":{"begin":1192,"end":1197},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T120","span":{"begin":1215,"end":1224},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T121","span":{"begin":1368,"end":1375},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T122","span":{"begin":1402,"end":1407},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T123","span":{"begin":1432,"end":1435},"obj":"http://purl.obolibrary.org/obo/CLO_0050389"},{"id":"T124","span":{"begin":1445,"end":1450},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T125","span":{"begin":1521,"end":1529},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T126","span":{"begin":1546,"end":1555},"obj":"http://purl.obolibrary.org/obo/CL_0000576"},{"id":"T127","span":{"begin":1642,"end":1645},"obj":"http://purl.obolibrary.org/obo/CLO_0009645"},{"id":"T128","span":{"begin":1642,"end":1645},"obj":"http://purl.obolibrary.org/obo/CLO_0050824"},{"id":"T129","span":{"begin":1677,"end":1680},"obj":"http://purl.obolibrary.org/obo/CLO_0009645"},{"id":"T130","span":{"begin":1677,"end":1680},"obj":"http://purl.obolibrary.org/obo/CLO_0050824"},{"id":"T131","span":{"begin":1839,"end":1859},"obj":"http://purl.obolibrary.org/obo/CL_0001065"},{"id":"T132","span":{"begin":1921,"end":1922},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T133","span":{"begin":1944,"end":1945},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T134","span":{"begin":2005,"end":2030},"obj":"http://purl.obolibrary.org/obo/PR_000001944"},{"id":"T135","span":{"begin":2065,"end":2068},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T136","span":{"begin":2069,"end":2072},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T137","span":{"begin":2088,"end":2094},"obj":"http://purl.obolibrary.org/obo/SO_0000418"},{"id":"T138","span":{"begin":2124,"end":2133},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T139","span":{"begin":2205,"end":2209},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T140","span":{"begin":2210,"end":2227},"obj":"http://purl.obolibrary.org/obo/CL_0000815"}],"text":"Figure 1 T-cell polarisation in COVID-19\nIL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs. IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9. IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10. IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells. Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages. In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells. At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6. IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF. In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages. CCR=C-C motif chemokine receptor. CCL=C-C motif chemokine ligand. CXCL=C-X-C motif chemokine ligand. CXCR=C-X-C chemokine receptor. Foxp=forkhead box protein. GATA=GATA-binding factor. GM-CSF=granulocyte-macrophage colony-stimulating factor. IL=interleukin. ILC2=type 2 innate lymphoid cell. MyD88=myeloid differentiation primary response protein. NF-κB=nuclear factor-kappa B. NLRP=NACHT, LRR, and PYD domains-containing protein. PU.1=transcription factor PU.1. RORC=nuclear receptor ROR-gamma. ST2=ST2 receptor. STAT=signal transducer and transcription activator. TGF=transforming growth factor. Th=T-helper. TLR=toll-like receptors. Treg=regulatory T cell."}

    LitCovid-PD-CHEBI

    {"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T81","span":{"begin":41,"end":43},"obj":"Chemical"},{"id":"T83","span":{"begin":138,"end":140},"obj":"Chemical"},{"id":"T85","span":{"begin":215,"end":217},"obj":"Chemical"},{"id":"T87","span":{"begin":345,"end":347},"obj":"Chemical"},{"id":"T89","span":{"begin":351,"end":353},"obj":"Chemical"},{"id":"T91","span":{"begin":388,"end":396},"obj":"Chemical"},{"id":"T92","span":{"begin":506,"end":511},"obj":"Chemical"},{"id":"T93","span":{"begin":516,"end":522},"obj":"Chemical"},{"id":"T94","span":{"begin":524,"end":526},"obj":"Chemical"},{"id":"T96","span":{"begin":785,"end":790},"obj":"Chemical"},{"id":"T97","span":{"begin":795,"end":801},"obj":"Chemical"},{"id":"T98","span":{"begin":847,"end":849},"obj":"Chemical"},{"id":"T100","span":{"begin":865,"end":867},"obj":"Chemical"},{"id":"T102","span":{"begin":874,"end":876},"obj":"Chemical"},{"id":"T104","span":{"begin":1005,"end":1007},"obj":"Chemical"},{"id":"T105","span":{"begin":1110,"end":1112},"obj":"Chemical"},{"id":"T108","span":{"begin":1252,"end":1254},"obj":"Chemical"},{"id":"T110","span":{"begin":1259,"end":1261},"obj":"Chemical"},{"id":"T112","span":{"begin":1270,"end":1272},"obj":"Chemical"},{"id":"T114","span":{"begin":1276,"end":1278},"obj":"Chemical"},{"id":"T116","span":{"begin":1283,"end":1285},"obj":"Chemical"},{"id":"T118","span":{"begin":1290,"end":1292},"obj":"Chemical"},{"id":"T120","span":{"begin":1300,"end":1302},"obj":"Chemical"},{"id":"T122","span":{"begin":1461,"end":1463},"obj":"Chemical"},{"id":"T124","span":{"begin":1471,"end":1473},"obj":"Chemical"},{"id":"T125","span":{"begin":1488,"end":1490},"obj":"Chemical"},{"id":"T126","span":{"begin":1603,"end":1606},"obj":"Chemical"},{"id":"T127","span":{"begin":1627,"end":1633},"obj":"Chemical"},{"id":"T128","span":{"begin":1662,"end":1668},"obj":"Chemical"},{"id":"T129","span":{"begin":1719,"end":1726},"obj":"Chemical"},{"id":"T130","span":{"begin":1754,"end":1756},"obj":"Chemical"},{"id":"T131","span":{"begin":1811,"end":1813},"obj":"Chemical"},{"id":"T133","span":{"begin":1908,"end":1915},"obj":"Chemical"},{"id":"T134","span":{"begin":1917,"end":1919},"obj":"Chemical"},{"id":"T137","span":{"begin":1991,"end":1998},"obj":"Chemical"},{"id":"T138","span":{"begin":2058,"end":2063},"obj":"Chemical"},{"id":"T139","span":{"begin":2167,"end":2169},"obj":"Chemical"}],"attributes":[{"id":"A81","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A82","pred":"chebi_id","subj":"T81","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A83","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A84","pred":"chebi_id","subj":"T83","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A85","pred":"chebi_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A86","pred":"chebi_id","subj":"T85","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A87","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A88","pred":"chebi_id","subj":"T87","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A89","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A90","pred":"chebi_id","subj":"T89","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A91","pred":"chebi_id","subj":"T91","obj":"http://purl.obolibrary.org/obo/CHEBI_35224"},{"id":"A92","pred":"chebi_id","subj":"T92","obj":"http://purl.obolibrary.org/obo/CHEBI_138154"},{"id":"A93","pred":"chebi_id","subj":"T93","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"},{"id":"A94","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A95","pred":"chebi_id","subj":"T94","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A96","pred":"chebi_id","subj":"T96","obj":"http://purl.obolibrary.org/obo/CHEBI_138154"},{"id":"A97","pred":"chebi_id","subj":"T97","obj":"http://purl.obolibrary.org/obo/CHEBI_138157"},{"id":"A98","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A99","pred":"chebi_id","subj":"T98","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A100","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A101","pred":"chebi_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A102","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A103","pred":"chebi_id","subj":"T102","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A104","pred":"chebi_id","subj":"T104","obj":"http://purl.obolibrary.org/obo/CHEBI_74120"},{"id":"A105","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A106","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A107","pred":"chebi_id","subj":"T105","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A108","pred":"chebi_i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1 T-cell polarisation in COVID-19\nIL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs. IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9. IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10. IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells. Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages. In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells. At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6. IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF. In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages. CCR=C-C motif chemokine receptor. CCL=C-C motif chemokine ligand. CXCL=C-X-C motif chemokine ligand. CXCR=C-X-C chemokine receptor. Foxp=forkhead box protein. GATA=GATA-binding factor. GM-CSF=granulocyte-macrophage colony-stimulating factor. IL=interleukin. ILC2=type 2 innate lymphoid cell. MyD88=myeloid differentiation primary response protein. NF-κB=nuclear factor-kappa B. NLRP=NACHT, LRR, and PYD domains-containing protein. PU.1=transcription factor PU.1. RORC=nuclear receptor ROR-gamma. ST2=ST2 receptor. STAT=signal transducer and transcription activator. TGF=transforming growth factor. Th=T-helper. TLR=toll-like receptors. Treg=regulatory T cell."}

    LitCovid-PD-GO-BP

    {"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T16","span":{"begin":138,"end":153},"obj":"http://purl.obolibrary.org/obo/GO_0032623"},{"id":"T17","span":{"begin":397,"end":403},"obj":"http://purl.obolibrary.org/obo/GO_0007613"},{"id":"T18","span":{"begin":554,"end":574},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T19","span":{"begin":554,"end":567},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T20","span":{"begin":934,"end":948},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T21","span":{"begin":2005,"end":2025},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T22","span":{"begin":2005,"end":2018},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T23","span":{"begin":2110,"end":2123},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T24","span":{"begin":2152,"end":2158},"obj":"http://purl.obolibrary.org/obo/GO_0040007"}],"text":"Figure 1 T-cell polarisation in COVID-19\nIL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs. IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9. IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10. IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells. Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages. In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells. At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6. IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF. In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages. CCR=C-C motif chemokine receptor. CCL=C-C motif chemokine ligand. CXCL=C-X-C motif chemokine ligand. CXCR=C-X-C chemokine receptor. Foxp=forkhead box protein. GATA=GATA-binding factor. GM-CSF=granulocyte-macrophage colony-stimulating factor. IL=interleukin. ILC2=type 2 innate lymphoid cell. MyD88=myeloid differentiation primary response protein. NF-κB=nuclear factor-kappa B. NLRP=NACHT, LRR, and PYD domains-containing protein. PU.1=transcription factor PU.1. RORC=nuclear receptor ROR-gamma. ST2=ST2 receptor. STAT=signal transducer and transcription activator. TGF=transforming growth factor. Th=T-helper. TLR=toll-like receptors. Treg=regulatory T cell."}

    LitCovid-sentences

    {"project":"LitCovid-sentences","denotations":[{"id":"T24","span":{"begin":0,"end":40},"obj":"Sentence"},{"id":"T25","span":{"begin":41,"end":214},"obj":"Sentence"},{"id":"T26","span":{"begin":215,"end":350},"obj":"Sentence"},{"id":"T27","span":{"begin":351,"end":523},"obj":"Sentence"},{"id":"T28","span":{"begin":524,"end":707},"obj":"Sentence"},{"id":"T29","span":{"begin":708,"end":817},"obj":"Sentence"},{"id":"T30","span":{"begin":818,"end":1037},"obj":"Sentence"},{"id":"T31","span":{"begin":1038,"end":1275},"obj":"Sentence"},{"id":"T32","span":{"begin":1276,"end":1478},"obj":"Sentence"},{"id":"T33","span":{"begin":1479,"end":1568},"obj":"Sentence"},{"id":"T34","span":{"begin":1569,"end":1602},"obj":"Sentence"},{"id":"T35","span":{"begin":1603,"end":1634},"obj":"Sentence"},{"id":"T36","span":{"begin":1635,"end":1669},"obj":"Sentence"},{"id":"T37","span":{"begin":1670,"end":1700},"obj":"Sentence"},{"id":"T38","span":{"begin":1701,"end":1727},"obj":"Sentence"},{"id":"T39","span":{"begin":1728,"end":1753},"obj":"Sentence"},{"id":"T40","span":{"begin":1754,"end":1810},"obj":"Sentence"},{"id":"T41","span":{"begin":1811,"end":1826},"obj":"Sentence"},{"id":"T42","span":{"begin":1827,"end":1860},"obj":"Sentence"},{"id":"T43","span":{"begin":1861,"end":1916},"obj":"Sentence"},{"id":"T44","span":{"begin":1917,"end":1946},"obj":"Sentence"},{"id":"T45","span":{"begin":1947,"end":1999},"obj":"Sentence"},{"id":"T46","span":{"begin":2000,"end":2031},"obj":"Sentence"},{"id":"T47","span":{"begin":2032,"end":2064},"obj":"Sentence"},{"id":"T48","span":{"begin":2065,"end":2082},"obj":"Sentence"},{"id":"T49","span":{"begin":2083,"end":2134},"obj":"Sentence"},{"id":"T50","span":{"begin":2135,"end":2166},"obj":"Sentence"},{"id":"T51","span":{"begin":2167,"end":2179},"obj":"Sentence"},{"id":"T52","span":{"begin":2180,"end":2204},"obj":"Sentence"},{"id":"T53","span":{"begin":2205,"end":2228},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Figure 1 T-cell polarisation in COVID-19\nIL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs. IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9. IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10. IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells. Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages. In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells. At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6. IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF. In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages. CCR=C-C motif chemokine receptor. CCL=C-C motif chemokine ligand. CXCL=C-X-C motif chemokine ligand. CXCR=C-X-C chemokine receptor. Foxp=forkhead box protein. GATA=GATA-binding factor. GM-CSF=granulocyte-macrophage colony-stimulating factor. IL=interleukin. ILC2=type 2 innate lymphoid cell. MyD88=myeloid differentiation primary response protein. NF-κB=nuclear factor-kappa B. NLRP=NACHT, LRR, and PYD domains-containing protein. PU.1=transcription factor PU.1. RORC=nuclear receptor ROR-gamma. ST2=ST2 receptor. STAT=signal transducer and transcription activator. TGF=transforming growth factor. Th=T-helper. TLR=toll-like receptors. Treg=regulatory T cell."}

    LitCovid-PubTator

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1 T-cell polarisation in COVID-19\nIL-33 released from virus-damaged cells might induce dysregulated GATA3+Foxp3+ Tregs and promote IL-2 production by dendritic cells, resulting in further expansion of Tregs. IL-33 might also elicit differentiation of ILC2, with TGFβ enhancing ST2 expression on these cells and facilitating production of IL-9. IL-9 in turn stimulates expansion of effector memory Vγ9Vδ2+ T cells with mixed Th1 and Th17 profiles that express CXCR3 and are recruited to the lungs by CXCL9 and CXCL10. IL-9 possibly induces its own transcription factor PU.1 and thus act in an autocrine and paracrine manner (along with TGFβ) to drive proliferation and survival of ILC2 and γδ T cells. Additional positive loops might be fed by IFNγ, which triggers production of CXCL9 and CXCL10 by macrophages. In severe forms of COVID-19, IL-33, along with IL-2 and IL-7 released by dendritic cells, might further stimulate T-cell expansion through STAT5 and induce production of large amounts of GM-CSF by γδ and T helper cells. At advanced stages of disease, aberrant activation of the MyD88-related NF-κB pathway and activation of the NLRP3 inflammasome might induce virus-exposed cells and infiltrating monocytes–macrophages to overproduce IL-1β, IL-23, and IL-6. IL-1β, IL-23, IL-6, and IL-7 act on STAT3 and RORC, thus promoting differentiation of CCR2+ T cells that are recruited to the lungs by CCL2 and CCL8 into γδT17 and Th17 cells producing IL-17 and GM-CSF. In turn, GM-CSF might further recruit and activate proinflammatory monocytes–macrophages. CCR=C-C motif chemokine receptor. CCL=C-C motif chemokine ligand. CXCL=C-X-C motif chemokine ligand. CXCR=C-X-C chemokine receptor. Foxp=forkhead box protein. GATA=GATA-binding factor. GM-CSF=granulocyte-macrophage colony-stimulating factor. IL=interleukin. ILC2=type 2 innate lymphoid cell. MyD88=myeloid differentiation primary response protein. NF-κB=nuclear factor-kappa B. NLRP=NACHT, LRR, and PYD domains-containing protein. PU.1=transcription factor PU.1. RORC=nuclear receptor ROR-gamma. ST2=ST2 receptor. STAT=signal transducer and transcription activator. TGF=transforming growth factor. Th=T-helper. TLR=toll-like receptors. Treg=regulatory T cell."}