PMC:7546716 / 5392-6466
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T76 | 40-45 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T77 | 129-138 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
T78 | 172-176 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T79 | 340-345 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T80 | 351-353 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T81 | 368-376 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T82 | 395-400 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T83 | 446-451 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T84 | 487-491 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
T85 | 535-537 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T86 | 592-597 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T87 | 605-607 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T88 | 673-678 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T89 | 755-763 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
T90 | 811-816 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
T91 | 856-858 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T92 | 915-917 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T93 | 929-931 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
T94 | 975-979 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
T95 | 980-984 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
T96 | 992-997 | Body_part | denotes | lungs | http://purl.org/sig/ont/fma/fma68877 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T7 | 172-176 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
T8 | 487-491 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T53 | 172-184 | Disease | denotes | lung disease | http://purl.obolibrary.org/obo/MONDO_0005275 |
T54 | 492-504 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
T55 | 1015-1023 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
T56 | 1064-1073 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T60 | 21-26 | http://purl.obolibrary.org/obo/CLO_0053477 | denotes | GATA3 |
T61 | 28-33 | http://purl.obolibrary.org/obo/PR_000001350 | denotes | Foxp3 |
T62 | 35-39 | http://purl.obolibrary.org/obo/CL_0000792 | denotes | Treg |
T63 | 40-45 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T64 | 172-176 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T65 | 172-176 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T66 | 306-309 | http://purl.obolibrary.org/obo/CLO_0051025 | denotes | ST2 |
T67 | 324-345 | http://purl.obolibrary.org/obo/CL_0001065 | denotes | innate lymphoid cells |
T68 | 395-400 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
T69 | 430-451 | http://purl.obolibrary.org/obo/CL_0001065 | denotes | innate lymphoid cells |
T70 | 487-491 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
T71 | 487-491 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
T72 | 590-597 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T73 | 598-600 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T74 | 671-678 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T75 | 689-690 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T76 | 735-736 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T77 | 809-816 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
T78 | 948-949 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T79 | 973-979 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cell |
T80 | 992-997 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lungs |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T58 | 351-353 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T60 | 535-537 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T62 | 605-607 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T64 | 705-713 | Chemical | denotes | effector | http://purl.obolibrary.org/obo/CHEBI_35224 |
T65 | 856-858 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T67 | 915-917 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
T69 | 929-931 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-HP
Id | Subject | Object | Predicate | Lexical cue | hp_id |
---|---|---|---|---|---|
T9 | 172-184 | Phenotype | denotes | lung disease | http://purl.obolibrary.org/obo/HP_0002088 |
T10 | 1064-1073 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T12 | 109-118 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
T13 | 492-504 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
T14 | 714-720 | http://purl.obolibrary.org/obo/GO_0007613 | denotes | memory |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T21 | 0-1074 | Sentence | denotes | The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might further enhance ST2 expression in innate lymphoid cells, and IL-33 is the key cytokine that drives these cells to differentiate into type 2 innate lymphoid cells (ILC2).17 ILC2 subsequently elicit lung inflammation by releasing large amounts of IL-9, which promotes their own survival and expands γδ T cells.18, 19 IL-9 is known to stimulate proliferation and expansion of Vγ9Vδ2+ T cells that have a predominantly effector memory phenotype and a combined Th1–Th17 cytokine response profile.19 When exposed to TGFβ, γδ T cells can also become an important source of IL-9.20 By acting in both autocrine and paracrine manners, IL-33-induced IL-9 might sustain a proinflammatory ILC2–γδT cell axis in the lungs of patients with COVID-19, thus initiating mild–moderate forms of pneumonia. |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
218 | 21-26 | Gene | denotes | GATA3 | Gene:2625 |
219 | 28-33 | Gene | denotes | Foxp3 | Gene:50943 |
220 | 188-193 | Gene | denotes | TGFβ2 | Gene:7042 |
221 | 306-309 | Gene | denotes | ST2 | Gene:6761 |
222 | 351-356 | Gene | denotes | IL-33 | Gene:90865 |
223 | 535-539 | Gene | denotes | IL-9 | Gene:3578 |
224 | 605-609 | Gene | denotes | IL-9 | Gene:3578 |
225 | 800-804 | Gene | denotes | TGFβ | Gene:7039 |
226 | 856-860 | Gene | denotes | IL-9 | Gene:3578 |
227 | 915-920 | Gene | denotes | IL-33 | Gene:90865 |
228 | 929-933 | Gene | denotes | IL-9 | Gene:3578 |
230 | 258-266 | Species | denotes | patients | Tax:9606 |
231 | 1001-1009 | Species | denotes | patients | Tax:9606 |
234 | 62-94 | Disease | denotes | impaired immunological tolerance | MESH:D018149 |
235 | 155-184 | Disease | denotes | autoinflammatory lung disease | MESH:D008171 |
236 | 272-280 | Disease | denotes | COVID-19 | MESH:C000657245 |
237 | 487-504 | Disease | denotes | lung inflammation | MESH:D011014 |
238 | 1015-1023 | Disease | denotes | COVID-19 | MESH:C000657245 |
239 | 1064-1073 | Disease | denotes | pneumonia | MESH:D011014 |
2_test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
33073244-28196763-66244519 | 185-187 | 28196763 | denotes | 16 |
33073244-32228226-66244520 | 281-283 | 32228226 | denotes | 11 |
33073244-31911623-66244521 | 459-461 | 31911623 | denotes | 17 |
33073244-26129648-66244522 | 598-600 | 26129648 | denotes | 18 |
33073244-27543964-66244523 | 602-604 | 27543964 | denotes | 19 |
33073244-27543964-66244524 | 781-783 | 27543964 | denotes | 19 |
33073244-27791087-66244525 | 861-863 | 27791087 | denotes | 20 |