PMC:7546716 / 5041-5681 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T71","span":{"begin":45,"end":53},"obj":"Body_part"},{"id":"T72","span":{"begin":82,"end":84},"obj":"Body_part"},{"id":"T73","span":{"begin":166,"end":168},"obj":"Body_part"},{"id":"T74","span":{"begin":183,"end":188},"obj":"Body_part"},{"id":"T75","span":{"begin":344,"end":349},"obj":"Body_part"},{"id":"T76","span":{"begin":391,"end":396},"obj":"Body_part"},{"id":"T77","span":{"begin":480,"end":489},"obj":"Body_part"},{"id":"T78","span":{"begin":523,"end":527},"obj":"Body_part"}],"attributes":[{"id":"A71","pred":"fma_id","subj":"T71","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A72","pred":"fma_id","subj":"T72","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A73","pred":"fma_id","subj":"T73","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A74","pred":"fma_id","subj":"T74","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A75","pred":"fma_id","subj":"T75","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A76","pred":"fma_id","subj":"T76","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A77","pred":"fma_id","subj":"T77","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T7","span":{"begin":523,"end":527},"obj":"Body_part"}],"attributes":[{"id":"A7","pred":"uberon_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T52","span":{"begin":0,"end":9},"obj":"Disease"},{"id":"T53","span":{"begin":523,"end":535},"obj":"Disease"}],"attributes":[{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0005249"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005275"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T54","span":{"begin":147,"end":150},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T55","span":{"begin":178,"end":182},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T56","span":{"begin":183,"end":188},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T57","span":{"begin":289,"end":294},"obj":"http://purl.obolibrary.org/obo/CLO_0053477"},{"id":"T58","span":{"begin":339,"end":343},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T59","span":{"begin":344,"end":349},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T60","span":{"begin":372,"end":377},"obj":"http://purl.obolibrary.org/obo/CLO_0053477"},{"id":"T61","span":{"begin":379,"end":384},"obj":"http://purl.obolibrary.org/obo/PR_000001350"},{"id":"T62","span":{"begin":386,"end":390},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T63","span":{"begin":391,"end":396},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T64","span":{"begin":523,"end":527},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T65","span":{"begin":523,"end":527},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T54","span":{"begin":82,"end":84},"obj":"Chemical"},{"id":"T56","span":{"begin":166,"end":168},"obj":"Chemical"}],"attributes":[{"id":"A54","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A55","pred":"chebi_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A56","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A57","pred":"chebi_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T8","span":{"begin":0,"end":9},"obj":"Phenotype"},{"id":"T9","span":{"begin":523,"end":535},"obj":"Phenotype"}],"attributes":[{"id":"A8","pred":"hp_id","subj":"T8","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"id":"A9","pred":"hp_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/HP_0002088"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T10","span":{"begin":245,"end":265},"obj":"http://purl.obolibrary.org/obo/GO_0000981"},{"id":"T11","span":{"begin":245,"end":258},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T12","span":{"begin":460,"end":469},"obj":"http://purl.obolibrary.org/obo/GO_0046903"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}

{"project":"LitCovid-PubTator","denotations":[{"id":"213","span":{"begin":82,"end":87},"obj":"Gene"},{"id":"214","span":{"begin":147,"end":150},"obj":"Gene"},{"id":"215","span":{"begin":166,"end":173},"obj":"Gene"},{"id":"216","span":{"begin":266,"end":287},"obj":"Gene"},{"id":"217","span":{"begin":289,"end":294},"obj":"Gene"},{"id":"218","span":{"begin":372,"end":377},"obj":"Gene"},{"id":"219","span":{"begin":379,"end":384},"obj":"Gene"},{"id":"220","span":{"begin":539,"end":544},"obj":"Gene"},{"id":"229","span":{"begin":11,"end":13},"obj":"Gene"},{"id":"230","span":{"begin":609,"end":617},"obj":"Species"},{"id":"234","span":{"begin":413,"end":445},"obj":"Disease"},{"id":"235","span":{"begin":506,"end":535},"obj":"Disease"},{"id":"236","span":{"begin":623,"end":631},"obj":"Disease"}],"attributes":[{"id":"A213","pred":"tao:has_database_id","subj":"213","obj":"Gene:90865"},{"id":"A214","pred":"tao:has_database_id","subj":"214","obj":"Gene:6761"},{"id":"A215","pred":"tao:has_database_id","subj":"215","obj":"Gene:9173"},{"id":"A216","pred":"tao:has_database_id","subj":"216","obj":"Gene:2625"},{"id":"A217","pred":"tao:has_database_id","subj":"217","obj":"Gene:2625"},{"id":"A218","pred":"tao:has_database_id","subj":"218","obj":"Gene:2625"},{"id":"A219","pred":"tao:has_database_id","subj":"219","obj":"Gene:50943"},{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"Gene:7042"},{"id":"A229","pred":"tao:has_database_id","subj":"229","obj":"Gene:50512"},{"id":"A230","pred":"tao:has_database_id","subj":"230","obj":"Tax:9606"},{"id":"A234","pred":"tao:has_database_id","subj":"234","obj":"MESH:D018149"},{"id":"A235","pred":"tao:has_database_id","subj":"235","obj":"MESH:D008171"},{"id":"A236","pred":"tao:has_database_id","subj":"236","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}

{"project":"2_test","denotations":[{"id":"33073244-28196763-66244519","span":{"begin":536,"end":538},"obj":"28196763"},{"id":"33073244-32228226-66244520","span":{"begin":632,"end":634},"obj":"32228226"}],"text":"pneumonia (eg, in the presence of individual cytokine or receptor polymorphisms), IL-33 might abnormally upregulate expression of its own receptor ST2 (also known as IL-1RL1) on Treg cells, resulting in increased expression of the canonical Th2 transcription factor GATA-binding factor 3 (GATA3), which impairs the suppressive function of Treg cells. The dysregulation of GATA3+ Foxp3+ Treg cells might result in impaired immunological tolerance and increased secretion of type 2 cytokines, thus promoting autoinflammatory lung disease.16 TGFβ2, which is also increased in the bronchoalveolar lavage fluid of patients with COVID-19,11 might"}