PMC:7546716 / 44111-44549 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T899","span":{"begin":103,"end":106},"obj":"Body_part"},{"id":"T900","span":{"begin":134,"end":139},"obj":"Body_part"},{"id":"T901","span":{"begin":141,"end":161},"obj":"Body_part"},{"id":"T902","span":{"begin":163,"end":173},"obj":"Body_part"},{"id":"T903","span":{"begin":168,"end":173},"obj":"Body_part"},{"id":"T904","span":{"begin":175,"end":186},"obj":"Body_part"},{"id":"T905","span":{"begin":188,"end":205},"obj":"Body_part"},{"id":"T906","span":{"begin":200,"end":205},"obj":"Body_part"},{"id":"T907","span":{"begin":207,"end":216},"obj":"Body_part"},{"id":"T908","span":{"begin":256,"end":261},"obj":"Body_part"},{"id":"T909","span":{"begin":327,"end":331},"obj":"Body_part"}],"attributes":[{"id":"A899","pred":"fma_id","subj":"T899","obj":"http://purl.org/sig/ont/fma/fma68761"},{"id":"A900","pred":"fma_id","subj":"T900","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A901","pred":"fma_id","subj":"T901","obj":"http://purl.org/sig/ont/fma/fma83023"},{"id":"A902","pred":"fma_id","subj":"T902","obj":"http://purl.org/sig/ont/fma/fma66784"},{"id":"A903","pred":"fma_id","subj":"T903","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A904","pred":"fma_id","subj":"T904","obj":"http://purl.org/sig/ont/fma/fma62860"},{"id":"A905","pred":"fma_id","subj":"T905","obj":"http://purl.org/sig/ont/fma/fma66772"},{"id":"A906","pred":"fma_id","subj":"T906","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A907","pred":"fma_id","subj":"T907","obj":"http://purl.org/sig/ont/fma/fma62851"},{"id":"A908","pred":"fma_id","subj":"T908","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A909","pred":"fma_id","subj":"T909","obj":"http://purl.org/sig/ont/fma/fma7195"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T53","span":{"begin":327,"end":331},"obj":"Body_part"}],"attributes":[{"id":"A53","pred":"uberon_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T256","span":{"begin":321,"end":338},"obj":"Disease"},{"id":"T258","span":{"begin":332,"end":338},"obj":"Disease"}],"attributes":[{"id":"A256","pred":"mondo_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/MONDO_0006502"},{"id":"A257","pred":"mondo_id","subj":"T256","obj":"http://purl.obolibrary.org/obo/MONDO_0015796"},{"id":"A258","pred":"mondo_id","subj":"T258","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T611","span":{"begin":132,"end":139},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T612","span":{"begin":168,"end":173},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T613","span":{"begin":188,"end":205},"obj":"http://purl.obolibrary.org/obo/CL_0000115"},{"id":"T614","span":{"begin":254,"end":261},"obj":"http://purl.obolibrary.org/obo/CL_0000084"},{"id":"T615","span":{"begin":327,"end":331},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T616","span":{"begin":327,"end":331},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T617","span":{"begin":413,"end":421},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T689","span":{"begin":14,"end":42},"obj":"Chemical"},{"id":"T690","span":{"begin":32,"end":42},"obj":"Chemical"},{"id":"T691","span":{"begin":84,"end":93},"obj":"Chemical"},{"id":"T692","span":{"begin":403,"end":412},"obj":"Chemical"}],"attributes":[{"id":"A689","pred":"chebi_id","subj":"T689","obj":"http://purl.obolibrary.org/obo/CHEBI_50218"},{"id":"A690","pred":"chebi_id","subj":"T690","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A691","pred":"chebi_id","subj":"T691","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A692","pred":"chebi_id","subj":"T692","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T83","span":{"begin":321,"end":338},"obj":"Phenotype"}],"attributes":[{"id":"A83","pred":"hp_id","subj":"T83","obj":"http://www.orpha.net/ORDO/Orphanet_178320"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T120","span":{"begin":14,"end":42},"obj":"http://purl.obolibrary.org/obo/GO_0051344"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}

{"project":"LitCovid-sentences","denotations":[{"id":"T188","span":{"begin":0,"end":438},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1727","span":{"begin":84,"end":106},"obj":"Gene"},{"id":"1728","span":{"begin":266,"end":269},"obj":"Gene"},{"id":"1803","span":{"begin":327,"end":338},"obj":"Disease"},{"id":"1804","span":{"begin":430,"end":438},"obj":"Disease"},{"id":"1818","span":{"begin":250,"end":255},"obj":"CellLine"}],"attributes":[{"id":"A1727","pred":"tao:has_database_id","subj":"1727","obj":"Gene:11540"},{"id":"A1728","pred":"tao:has_database_id","subj":"1728","obj":"Gene:21926"},{"id":"A1803","pred":"tao:has_database_id","subj":"1803","obj":"MESH:D055370"},{"id":"A1804","pred":"tao:has_database_id","subj":"1804","obj":"MESH:D006470"},{"id":"A1818","pred":"tao:has_database_id","subj":"1818","obj":"CVCL:0042"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Non-selective phosphodiesterase inhibitors (eg, pentoxifylline) Phosphodiesterases (adenosine receptor A2A-dependent mechanisms) γδ T cells, alveolar macrophages, mast cells, neutrophils, endothelial cells, platelets Might inhibit proinflammatory Vγ9Vδ2 T cells and TNF release; anti-inflammatory effects in experimental acute lung injury; haemorheological and antithrombotic properties; broad-spectrum antiviral activity Risk of bleeding"}