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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T6","span":{"begin":953,"end":959},"obj":"Body_part"}],"attributes":[{"id":"A6","pred":"uberon_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"Transcriptomic analyses of bronchoalveolar lavage fluid from patients with COVID-19 have revealed a strong upregulation of IL-33.11 IL-33 is a cytokine of the IL-1 family that is expressed in barrier tissues and exerts pleiotropic functions. In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T43","span":{"begin":75,"end":83},"obj":"Disease"},{"id":"T44","span":{"begin":339,"end":348},"obj":"Disease"},{"id":"T45","span":{"begin":613,"end":625},"obj":"Disease"},{"id":"T46","span":{"begin":655,"end":663},"obj":"Disease"},{"id":"T47","span":{"begin":1036,"end":1044},"obj":"Disease"}],"attributes":[{"id":"A43","pred":"mondo_id","subj":"T43","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A44","pred":"mondo_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A45","pred":"mondo_id","subj":"T45","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A46","pred":"mondo_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A47","pred":"mondo_id","subj":"T47","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"Transcriptomic analyses of bronchoalveolar lavage fluid from patients with COVID-19 have revealed a strong upregulation of IL-33.11 IL-33 is a cytokine of the IL-1 family that is expressed in barrier tissues and exerts pleiotropic functions. In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

LitCovid-PD-CLO

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T37","span":{"begin":98,"end":99},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T38","span":{"begin":141,"end":142},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T39","span":{"begin":249,"end":254},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T40","span":{"begin":302,"end":312},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T41","span":{"begin":322,"end":327},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T42","span":{"begin":441,"end":446},"obj":"http://purl.obolibrary.org/obo/PR_000001350"},{"id":"T43","span":{"begin":462,"end":466},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T44","span":{"begin":491,"end":496},"obj":"http://purl.obolibrary.org/obo/PR_000001013"},{"id":"T45","span":{"begin":498,"end":521},"obj":"http://purl.obolibrary.org/obo/CL_0000782"},{"id":"T46","span":{"begin":533,"end":537},"obj":"http://purl.obolibrary.org/obo/PR_000001379"},{"id":"T47","span":{"begin":552,"end":556},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T48","span":{"begin":557,"end":561},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T49","span":{"begin":724,"end":728},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T50","span":{"begin":770,"end":771},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T51","span":{"begin":865,"end":870},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T52","span":{"begin":906,"end":910},"obj":"http://purl.obolibrary.org/obo/CL_0000792"},{"id":"T53","span":{"begin":911,"end":915},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Transcriptomic analyses of bronchoalveolar lavage fluid from patients with COVID-19 have revealed a strong upregulation of IL-33.11 IL-33 is a cytokine of the IL-1 family that is expressed in barrier tissues and exerts pleiotropic functions. In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T38","span":{"begin":123,"end":125},"obj":"Chemical"},{"id":"T40","span":{"begin":132,"end":134},"obj":"Chemical"},{"id":"T42","span":{"begin":159,"end":161},"obj":"Chemical"},{"id":"T44","span":{"begin":256,"end":258},"obj":"Chemical"},{"id":"T46","span":{"begin":393,"end":395},"obj":"Chemical"},{"id":"T48","span":{"begin":533,"end":535},"obj":"Chemical"},{"id":"T50","span":{"begin":882,"end":884},"obj":"Chemical"}],"attributes":[{"id":"A38","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A39","pred":"chebi_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A40","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A41","pred":"chebi_id","subj":"T40","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A42","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A43","pred":"chebi_id","subj":"T42","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A44","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A45","pred":"chebi_id","subj":"T44","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A46","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A47","pred":"chebi_id","subj":"T46","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A48","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A49","pred":"chebi_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A50","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A51","pred":"chebi_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"}],"text":"Transcriptomic analyses of bronchoalveolar lavage fluid from patients with COVID-19 have revealed a strong upregulation of IL-33.11 IL-33 is a cytokine of the IL-1 family that is expressed in barrier tissues and exerts pleiotropic functions. In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T7","span":{"begin":557,"end":571},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T8","span":{"begin":613,"end":625},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T9","span":{"begin":845,"end":860},"obj":"http://purl.obolibrary.org/obo/GO_0006955"}],"text":"Transcriptomic analyses of bronchoalveolar lavage fluid from patients with COVID-19 have revealed a strong upregulation of IL-33.11 IL-33 is a cytokine of the IL-1 family that is expressed in barrier tissues and exerts pleiotropic functions. In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T17","span":{"begin":0,"end":241},"obj":"Sentence"},{"id":"T18","span":{"begin":242,"end":1070},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Transcriptomic analyses of bronchoalveolar lavage fluid from patients with COVID-19 have revealed a strong upregulation of IL-33.11 IL-33 is a cytokine of the IL-1 family that is expressed in barrier tissues and exerts pleiotropic functions. In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"163","span":{"begin":123,"end":128},"obj":"Gene"},{"id":"164","span":{"begin":132,"end":137},"obj":"Gene"},{"id":"165","span":{"begin":159,"end":163},"obj":"Gene"},{"id":"166","span":{"begin":256,"end":261},"obj":"Gene"},{"id":"167","span":{"begin":393,"end":398},"obj":"Gene"},{"id":"168","span":{"begin":408,"end":412},"obj":"Gene"},{"id":"169","span":{"begin":441,"end":446},"obj":"Gene"},{"id":"170","span":{"begin":491,"end":496},"obj":"Gene"},{"id":"171","span":{"begin":533,"end":537},"obj":"Gene"},{"id":"172","span":{"begin":793,"end":798},"obj":"Gene"},{"id":"173","span":{"begin":882,"end":887},"obj":"Gene"},{"id":"174","span":{"begin":61,"end":69},"obj":"Species"},{"id":"175","span":{"begin":655,"end":665},"obj":"Species"},{"id":"176","span":{"begin":75,"end":83},"obj":"Disease"},{"id":"177","span":{"begin":339,"end":348},"obj":"Disease"},{"id":"178","span":{"begin":613,"end":625},"obj":"Disease"},{"id":"179","span":{"begin":641,"end":649},"obj":"Disease"},{"id":"180","span":{"begin":941,"end":972},"obj":"Disease"},{"id":"181","span":{"begin":1036,"end":1044},"obj":"Disease"}],"attributes":[{"id":"A163","pred":"tao:has_database_id","subj":"163","obj":"Gene:90865"},{"id":"A164","pred":"tao:has_database_id","subj":"164","obj":"Gene:90865"},{"id":"A165","pred":"tao:has_database_id","subj":"165","obj":"Gene:3552"},{"id":"A166","pred":"tao:has_database_id","subj":"166","obj":"Gene:90865"},{"id":"A167","pred":"tao:has_database_id","subj":"167","obj":"Gene:90865"},{"id":"A168","pred":"tao:has_database_id","subj":"168","obj":"Gene:7039"},{"id":"A169","pred":"tao:has_database_id","subj":"169","obj":"Gene:50943"},{"id":"A170","pred":"tao:has_database_id","subj":"170","obj":"Gene:3687"},{"id":"A171","pred":"tao:has_database_id","subj":"171","obj":"Gene:3558"},{"id":"A172","pred":"tao:has_database_id","subj":"172","obj":"Gene:2167"},{"id":"A173","pred":"tao:has_database_id","subj":"173","obj":"Gene:90865"},{"id":"A174","pred":"tao:has_database_id","subj":"174","obj":"Tax:9606"},{"id":"A175","pred":"tao:has_database_id","subj":"175","obj":"Tax:2697049"},{"id":"A176","pred":"tao:has_database_id","subj":"176","obj":"MESH:C000657245"},{"id":"A177","pred":"tao:has_database_id","subj":"177","obj":"MESH:D007239"},{"id":"A178","pred":"tao:has_database_id","subj":"178","obj":"MESH:D007249"},{"id":"A179","pred":"tao:has_database_id","subj":"179","obj":"MESH:D007239"},{"id":"A180","pred":"tao:has_database_id","subj":"180","obj":"MESH:D012140"},{"id":"A181","pred":"tao:has_database_id","subj":"181","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Transcriptomic analyses of bronchoalveolar lavage fluid from patients with COVID-19 have revealed a strong upregulation of IL-33.11 IL-33 is a cytokine of the IL-1 family that is expressed in barrier tissues and exerts pleiotropic functions. In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

2_test

{"project":"2_test","denotations":[{"id":"33073244-32228226-66244513","span":{"begin":129,"end":131},"obj":"32228226"},{"id":"33073244-31057533-66244514","span":{"begin":369,"end":371},"obj":"31057533"},{"id":"33073244-25043027-66244515","span":{"begin":473,"end":475},"obj":"25043027"},{"id":"33073244-25217167-66244516","span":{"begin":626,"end":628},"obj":"25217167"},{"id":"33073244-32460357-66244517","span":{"begin":734,"end":736},"obj":"32460357"},{"id":"33073244-32398875-66244518","span":{"begin":811,"end":813},"obj":"32398875"}],"text":"Transcriptomic analyses of bronchoalveolar lavage fluid from patients with COVID-19 have revealed a strong upregulation of IL-33.11 IL-33 is a cytokine of the IL-1 family that is expressed in barrier tissues and exerts pleiotropic functions. In the lungs, IL-33 is promptly released, mainly by injured epithelial alveolar cells, following infection and cellular damage.12 Among its functions, IL-33 enhances TGFβ-mediated differentiation of Foxp3+ regulatory T (Treg) cells13 and stimulates CD11c+ myeloid dendritic cells to secrete IL-2, which drives Treg cell expansion, thus ultimately promoting resolution of inflammation.14 Individuals infected with SARS-CoV-2 who develop milder symptoms tend to have large numbers of Treg cells10 and alveolar macrophages showing a scavenger resolving (FABP4+) phenotype.15 In the presence of an adequate immune response and virus clearance, IL-33 might drive rapid Treg cell-dependent restoration of respiratory tissue homoeostasis, which probably accounts for the mild or asymptomatic forms of COVID-19 seen in most individuals."}

PMC:7546716 / 3831-4901 JSONTXT

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PMC:7546716 / 3831-4901 JSON TXT