PMC:7546716 / 29921-30510 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7546716","sourcedb":"PMC","sourceid":"7546716","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7546716","text":"Lung alveolar inflammation in COVID-19 is accompanied by loose interstitial fibrosis and can result in widespread fibrotic changes.79 IL-33 could also be important at these later stages of the disease. In a bleomycin-induced pulmonary fibrosis mouse model, the IL-33–ST2 axis is required to induce alternatively activated M2 macrophages and ILC2 to release key profibrotic cytokines.80 IL-33-activated mast cells might also play a role in organ fibrosis.81 Most remarkably, IL-33 has been shown to induce epithelial-to-mesechymal transition of type 2 pneumocytes through TGFβ signalling.82","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T563","span":{"begin":0,"end":4},"obj":"Body_part"},{"id":"T564","span":{"begin":5,"end":13},"obj":"Body_part"},{"id":"T565","span":{"begin":134,"end":136},"obj":"Body_part"},{"id":"T566","span":{"begin":261,"end":263},"obj":"Body_part"},{"id":"T567","span":{"begin":271,"end":275},"obj":"Body_part"},{"id":"T568","span":{"begin":325,"end":336},"obj":"Body_part"},{"id":"T569","span":{"begin":373,"end":382},"obj":"Body_part"},{"id":"T570","span":{"begin":386,"end":388},"obj":"Body_part"},{"id":"T571","span":{"begin":402,"end":412},"obj":"Body_part"},{"id":"T572","span":{"begin":407,"end":412},"obj":"Body_part"},{"id":"T573","span":{"begin":439,"end":444},"obj":"Body_part"},{"id":"T574","span":{"begin":474,"end":476},"obj":"Body_part"},{"id":"T575","span":{"begin":544,"end":562},"obj":"Body_part"}],"attributes":[{"id":"A563","pred":"fma_id","subj":"T563","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A564","pred":"fma_id","subj":"T564","obj":"http://purl.org/sig/ont/fma/fma264783"},{"id":"A565","pred":"fma_id","subj":"T565","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A566","pred":"fma_id","subj":"T566","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A567","pred":"fma_id","subj":"T567","obj":"http://purl.org/sig/ont/fma/fma12520"},{"id":"A568","pred":"fma_id","subj":"T568","obj":"http://purl.org/sig/ont/fma/fma63261"},{"id":"A569","pred":"fma_id","subj":"T569","obj":"http://purl.org/sig/ont/fma/fma84050"},{"id":"A570","pred":"fma_id","subj":"T570","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A571","pred":"fma_id","subj":"T571","obj":"http://purl.org/sig/ont/fma/fma66784"},{"id":"A572","pred":"fma_id","subj":"T572","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A573","pred":"fma_id","subj":"T573","obj":"http://purl.org/sig/ont/fma/fma67498"},{"id":"A574","pred":"fma_id","subj":"T574","obj":"http://purl.org/sig/ont/fma/fma86578"},{"id":"A575","pred":"fma_id","subj":"T575","obj":"http://purl.org/sig/ont/fma/fma62501"},{"subj":"T563","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T564","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T565","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T566","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T567","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T568","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T569","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T570","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T571","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T572","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T573","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T574","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T575","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T37","span":{"begin":0,"end":4},"obj":"Body_part"},{"id":"T38","span":{"begin":439,"end":444},"obj":"Body_part"}],"attributes":[{"id":"A37","pred":"uberon_id","subj":"T37","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A38","pred":"uberon_id","subj":"T38","obj":"http://purl.obolibrary.org/obo/UBERON_0000062"},{"subj":"T37","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T38","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T177","span":{"begin":14,"end":26},"obj":"Disease"},{"id":"T178","span":{"begin":30,"end":38},"obj":"Disease"},{"id":"T179","span":{"begin":225,"end":243},"obj":"Disease"}],"attributes":[{"id":"A177","pred":"mondo_id","subj":"T177","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A178","pred":"mondo_id","subj":"T178","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A179","pred":"mondo_id","subj":"T179","obj":"http://purl.obolibrary.org/obo/MONDO_0002771"},{"subj":"T177","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T178","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T179","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T410","span":{"begin":0,"end":4},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T411","span":{"begin":0,"end":4},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T412","span":{"begin":205,"end":206},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T413","span":{"begin":244,"end":249},"obj":"http://purl.obolibrary.org/obo/CLO_0007836"},{"id":"T414","span":{"begin":267,"end":270},"obj":"http://purl.obolibrary.org/obo/CLO_0051025"},{"id":"T415","span":{"begin":312,"end":321},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T416","span":{"begin":392,"end":401},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T417","span":{"begin":407,"end":412},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T418","span":{"begin":429,"end":430},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T419","span":{"begin":439,"end":444},"obj":"http://purl.obolibrary.org/obo/UBERON_0003103"},{"id":"T420","span":{"begin":480,"end":483},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T421","span":{"begin":505,"end":515},"obj":"http://purl.obolibrary.org/obo/CL_0000066"},{"id":"T422","span":{"begin":576,"end":586},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"attributes":[{"subj":"T410","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T411","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T412","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T413","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T414","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T415","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T416","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T417","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T418","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T419","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T420","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T421","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T422","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T437","span":{"begin":134,"end":136},"obj":"Chemical"},{"id":"T439","span":{"begin":207,"end":216},"obj":"Chemical"},{"id":"T440","span":{"begin":261,"end":263},"obj":"Chemical"},{"id":"T442","span":{"begin":322,"end":324},"obj":"Chemical"},{"id":"T444","span":{"begin":386,"end":388},"obj":"Chemical"},{"id":"T446","span":{"begin":474,"end":476},"obj":"Chemical"}],"attributes":[{"id":"A437","pred":"chebi_id","subj":"T437","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A438","pred":"chebi_id","subj":"T437","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A439","pred":"chebi_id","subj":"T439","obj":"http://purl.obolibrary.org/obo/CHEBI_22907"},{"id":"A440","pred":"chebi_id","subj":"T440","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A441","pred":"chebi_id","subj":"T440","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A442","pred":"chebi_id","subj":"T442","obj":"http://purl.obolibrary.org/obo/CHEBI_34827"},{"id":"A443","pred":"chebi_id","subj":"T442","obj":"http://purl.obolibrary.org/obo/CHEBI_51112"},{"id":"A444","pred":"chebi_id","subj":"T444","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A445","pred":"chebi_id","subj":"T444","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"id":"A446","pred":"chebi_id","subj":"T446","obj":"http://purl.obolibrary.org/obo/CHEBI_63895"},{"id":"A447","pred":"chebi_id","subj":"T446","obj":"http://purl.obolibrary.org/obo/CHEBI_74072"},{"subj":"T437","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T439","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T440","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T442","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T444","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T446","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T51","span":{"begin":225,"end":243},"obj":"Phenotype"}],"attributes":[{"id":"A51","pred":"hp_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/HP_0002206"},{"subj":"T51","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T81","span":{"begin":14,"end":26},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T82","span":{"begin":576,"end":586},"obj":"http://purl.obolibrary.org/obo/GO_0023052"}],"attributes":[{"subj":"T81","pred":"source","obj":"LitCovid-PD-GO-BP"},{"subj":"T82","pred":"source","obj":"LitCovid-PD-GO-BP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T129","span":{"begin":0,"end":201},"obj":"Sentence"},{"id":"T130","span":{"begin":202,"end":589},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T129","pred":"source","obj":"LitCovid-sentences"},{"subj":"T130","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1261","span":{"begin":134,"end":139},"obj":"Gene"},{"id":"1262","span":{"begin":261,"end":266},"obj":"Gene"},{"id":"1263","span":{"begin":267,"end":270},"obj":"Gene"},{"id":"1264","span":{"begin":386,"end":391},"obj":"Gene"},{"id":"1265","span":{"begin":474,"end":479},"obj":"Gene"},{"id":"1266","span":{"begin":571,"end":575},"obj":"Gene"},{"id":"1267","span":{"begin":244,"end":249},"obj":"Species"},{"id":"1268","span":{"begin":207,"end":216},"obj":"Chemical"},{"id":"1269","span":{"begin":14,"end":26},"obj":"Disease"},{"id":"1270","span":{"begin":30,"end":38},"obj":"Disease"},{"id":"1271","span":{"begin":76,"end":84},"obj":"Disease"},{"id":"1272","span":{"begin":225,"end":243},"obj":"Disease"},{"id":"1273","span":{"begin":445,"end":453},"obj":"Disease"}],"attributes":[{"id":"A1261","pred":"tao:has_database_id","subj":"1261","obj":"Gene:90865"},{"id":"A1262","pred":"tao:has_database_id","subj":"1262","obj":"Gene:77125"},{"id":"A1263","pred":"tao:has_database_id","subj":"1263","obj":"Gene:17082"},{"id":"A1264","pred":"tao:has_database_id","subj":"1264","obj":"Gene:77125"},{"id":"A1265","pred":"tao:has_database_id","subj":"1265","obj":"Gene:77125"},{"id":"A1266","pred":"tao:has_database_id","subj":"1266","obj":"Gene:7039"},{"id":"A1267","pred":"tao:has_database_id","subj":"1267","obj":"Tax:10090"},{"id":"A1268","pred":"tao:has_database_id","subj":"1268","obj":"MESH:D001761"},{"id":"A1269","pred":"tao:has_database_id","subj":"1269","obj":"MESH:D007249"},{"id":"A1270","pred":"tao:has_database_id","subj":"1270","obj":"MESH:C000657245"},{"id":"A1271","pred":"tao:has_database_id","subj":"1271","obj":"MESH:D005355"},{"id":"A1272","pred":"tao:has_database_id","subj":"1272","obj":"MESH:D011658"},{"id":"A1273","pred":"tao:has_database_id","subj":"1273","obj":"MESH:D005355"},{"subj":"1261","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1262","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1263","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1264","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1265","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1266","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1267","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1268","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1269","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1270","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1271","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1272","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1273","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"2_test","denotations":[{"id":"33073244-32422178-66244628","span":{"begin":131,"end":133},"obj":"32422178"},{"id":"33073244-24985397-66244629","span":{"begin":383,"end":385},"obj":"24985397"},{"id":"33073244-30308508-66244630","span":{"begin":587,"end":589},"obj":"30308508"}],"attributes":[{"subj":"33073244-32422178-66244628","pred":"source","obj":"2_test"},{"subj":"33073244-24985397-66244629","pred":"source","obj":"2_test"},{"subj":"33073244-30308508-66244630","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93ece5","default":true},{"id":"LitCovid-PD-UBERON","color":"#eccb93"},{"id":"LitCovid-PD-MONDO","color":"#b193ec"},{"id":"LitCovid-PD-CLO","color":"#93ec97"},{"id":"LitCovid-PD-CHEBI","color":"#ec93a8"},{"id":"LitCovid-PD-HP","color":"#93c2ec"},{"id":"LitCovid-PD-GO-BP","color":"#dcec93"},{"id":"LitCovid-sentences","color":"#e293ec"},{"id":"LitCovid-PubTator","color":"#93ecc7"},{"id":"2_test","color":"#ecad93"}]}]}}