PMC:7546716 / 18786-20094
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T350 | 117-124 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T351 | 313-317 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T352 | 313-315 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T353 | 350-352 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T354 | 492-501 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T355 | 649-652 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T356 | 700-709 | Body_part | denotes | endosomal | http://purl.org/sig/ont/fma/fma67180 |
| T357 | 771-774 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T358 | 925-932 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T359 | 951-958 | Body_part | denotes | heparan | http://purl.org/sig/ont/fma/fma67110 |
| T360 | 1123-1128 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T361 | 1156-1160 | Body_part | denotes | IL-1 | http://purl.org/sig/ont/fma/fma86583 |
| T362 | 1156-1158 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T363 | 1181-1190 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T364 | 1195-1205 | Body_part | denotes | chemokines | http://purl.org/sig/ont/fma/fma241981 |
| T365 | 1216-1218 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T366 | 1222-1224 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T367 | 1228-1230 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T368 | 1238-1240 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T369 | 1276-1278 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
| T370 | 1289-1291 | Body_part | denotes | IL | http://purl.org/sig/ont/fma/fma86578 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T111 | 433-445 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T112 | 812-824 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T113 | 1017-1026 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T270 | 16-26 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T271 | 274-284 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T272 | 285-287 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T273 | 288-298 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | Signalling |
| T274 | 365-368 | http://purl.obolibrary.org/obo/CLO_0051025 | denotes | ST2 |
| T275 | 388-396 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T276 | 407-415 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T277 | 599-601 | http://purl.obolibrary.org/obo/CLO_0001382 | denotes | 48 |
| T278 | 653-660 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T279 | 872-880 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T280 | 891-895 | http://purl.obolibrary.org/obo/CLO_0050768 | denotes | TLR2 |
| T281 | 913-918 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T282 | 988-992 | http://purl.obolibrary.org/obo/CLO_0050768 | denotes | TLR2 |
| T283 | 1011-1016 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T284 | 1042-1043 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T285 | 1066-1076 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T286 | 1087-1097 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signalling |
| T287 | 1109-1114 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T288 | 1123-1128 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T289 | 1171-1172 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T290 | 1216-1220 | http://purl.obolibrary.org/obo/CLO_0053704 | denotes | IL-8 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T270 | 117-124 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T271 | 194-202 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T272 | 313-315 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T274 | 350-352 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T276 | 534-543 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T277 | 544-554 | Chemical | denotes | interferon | http://purl.obolibrary.org/obo/CHEBI_52999 |
| T278 | 755-774 | Chemical | denotes | double-stranded RNA | http://purl.obolibrary.org/obo/CHEBI_67208 |
| T279 | 925-932 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T280 | 951-958 | Chemical | denotes | heparan | http://purl.obolibrary.org/obo/CHEBI_24500 |
| T281 | 959-967 | Chemical | denotes | sulphate | http://purl.obolibrary.org/obo/CHEBI_16189 |
| T282 | 1156-1158 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T284 | 1167-1169 | Chemical | denotes | NF | http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224 |
| T287 | 1216-1218 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T289 | 1222-1224 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T291 | 1228-1230 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T293 | 1238-1240 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T295 | 1276-1278 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T297 | 1289-1291 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T21 | 1017-1026 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T49 | 16-26 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
| T50 | 288-298 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | Signalling |
| T51 | 433-445 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T52 | 771-786 | http://purl.obolibrary.org/obo/GO_0039703 | denotes | RNA replication |
| T53 | 812-824 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T54 | 1066-1076 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
| T55 | 1087-1097 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signalling |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T79 | 0-1308 | Sentence | denotes | An imbalance in signalling from toll-like receptor (TLR) pathways, with the myeloid differentiation primary response protein (MyD88) pathway predominating over the TIR domain-containing adapter molecule 1 (TICAM-1, also known as TRIF) pathways, might further increase NLRP3 activation.48 Signalling downstream of IL-1 family receptors, including the IL-33 receptor ST2, and downstream of membrane TLRs, can activate MyD88 and elicit inflammation; whereas TRIF-mediated pathways downstream of endosomal TLRs would be expected to mount antiviral interferon responses and protect against coronaviruses.48, 49 Although coronaviruses are single-stranded RNA viruses that are predicted to bind directly to endosomal TLR7 and TLR8, and indirectly to TLR3 (using double-stranded RNA replication intermediates), aberrant inflammation induced by coronaviruses might instead involve membrane-expressed TLR2, as suggested by virus spike protein interactions with heparan sulphate-enriched regions of TLR2 in studies of the mouse hepatitis coronavirus.50 A predominance of MyD88 signalling over TRIF signalling would lead virus-exposed cells to produce high amounts of IL-1β, and NF-κB-induced cytokines and chemokines (eg, TNF, IL-8, IL-6, IL-12p40, IL-23, CCL2) rather than interferons, IL-12p35 and IL-12p70.30, 49, 50 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 800 | 126-131 | Gene | denotes | MyD88 | Gene:4615 |
| 801 | 164-204 | Gene | denotes | TIR domain-containing adapter molecule 1 | Gene:148022 |
| 802 | 206-213 | Gene | denotes | TICAM-1 | Gene:148022 |
| 803 | 229-233 | Gene | denotes | TRIF | Gene:148022 |
| 804 | 268-273 | Gene | denotes | NLRP3 | Gene:114548 |
| 805 | 313-317 | Gene | denotes | IL-1 | Gene:3552 |
| 806 | 416-421 | Gene | denotes | MyD88 | Gene:4615 |
| 807 | 455-459 | Gene | denotes | TRIF | Gene:148022 |
| 808 | 891-895 | Gene | denotes | TLR2 | Gene:7097 |
| 809 | 988-992 | Gene | denotes | TLR2 | Gene:7097 |
| 810 | 1060-1065 | Gene | denotes | MyD88 | Gene:4615 |
| 811 | 1082-1086 | Gene | denotes | TRIF | Gene:148022 |
| 812 | 1156-1161 | Gene | denotes | IL-1β | Gene:3552 |
| 813 | 1167-1172 | Gene | denotes | NF-κB | Gene:4790 |
| 814 | 1211-1214 | Gene | denotes | TNF | Gene:7124 |
| 815 | 1216-1220 | Gene | denotes | IL-8 | Gene:3576 |
| 816 | 1222-1226 | Gene | denotes | IL-6 | Gene:3569 |
| 817 | 1238-1243 | Gene | denotes | IL-23 | Gene:51561 |
| 818 | 1245-1249 | Gene | denotes | CCL2 | Gene:6347 |
| 819 | 585-598 | Species | denotes | coronaviruses | Tax:11118 |
| 820 | 615-628 | Species | denotes | coronaviruses | Tax:11118 |
| 821 | 836-849 | Species | denotes | coronaviruses | Tax:11118 |
| 822 | 1011-1016 | Species | denotes | mouse | Tax:10090 |
| 823 | 951-967 | Chemical | denotes | heparan sulphate | MESH:D006497 |
| 824 | 433-445 | Disease | denotes | inflammation | MESH:D007249 |
| 825 | 492-506 | Disease | denotes | endosomal TLRs | |
| 826 | 812-824 | Disease | denotes | inflammation | MESH:D007249 |
| 827 | 1017-1038 | Disease | denotes | hepatitis coronavirus | MESH:D056486 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33073244-26015500-66244583 | 603-605 | 26015500 | denotes | 49 |
| 33073244-19740307-66244584 | 1039-1041 | 19740307 | denotes | 50 |
| 33073244-32661059-66244585 | 1298-1300 | 32661059 | denotes | 30 |
| 33073244-26015500-66244586 | 1302-1304 | 26015500 | denotes | 49 |
| 33073244-19740307-66244587 | 1306-1308 | 19740307 | denotes | 50 |