PMC:7546130 / 11081-11824 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T78","span":{"begin":477,"end":488},"obj":"Body_part"}],"attributes":[{"id":"A78","pred":"fma_id","subj":"T78","obj":"http://purl.org/sig/ont/fma/fma63916"}],"text":"We consider this case an example of neurological manifestations possibly related to COVID-19, characterized by vascular damage predominantly involving microvessels. The absence of pathological confirmation represents a major limitation, but similar MRI patterns [2] and recent pathological correlations seem to support a microangiopathic substrate [8]. Different mechanisms including a systemic procoagulative status and systemic and local inflammatory processes involving the endothelium, most likely via the ACE2 receptor, and eventual immune-mediated vascular injury could be considered [11]. Clinicians should be aware of the possible severe neurological complications in COVID-19 patients and of the role of MRI in their characterization."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T56","span":{"begin":477,"end":488},"obj":"Body_part"}],"attributes":[{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0001986"}],"text":"We consider this case an example of neurological manifestations possibly related to COVID-19, characterized by vascular damage predominantly involving microvessels. The absence of pathological confirmation represents a major limitation, but similar MRI patterns [2] and recent pathological correlations seem to support a microangiopathic substrate [8]. Different mechanisms including a systemic procoagulative status and systemic and local inflammatory processes involving the endothelium, most likely via the ACE2 receptor, and eventual immune-mediated vascular injury could be considered [11]. Clinicians should be aware of the possible severe neurological complications in COVID-19 patients and of the role of MRI in their characterization."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T57","span":{"begin":84,"end":92},"obj":"Disease"},{"id":"T58","span":{"begin":563,"end":569},"obj":"Disease"},{"id":"T59","span":{"begin":676,"end":684},"obj":"Disease"}],"attributes":[{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0021178"},{"id":"A59","pred":"mondo_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"We consider this case an example of neurological manifestations possibly related to COVID-19, characterized by vascular damage predominantly involving microvessels. The absence of pathological confirmation represents a major limitation, but similar MRI patterns [2] and recent pathological correlations seem to support a microangiopathic substrate [8]. Different mechanisms including a systemic procoagulative status and systemic and local inflammatory processes involving the endothelium, most likely via the ACE2 receptor, and eventual immune-mediated vascular injury could be considered [11]. Clinicians should be aware of the possible severe neurological complications in COVID-19 patients and of the role of MRI in their characterization."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T107","span":{"begin":217,"end":218},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T108","span":{"begin":319,"end":320},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T109","span":{"begin":384,"end":385},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T110","span":{"begin":477,"end":488},"obj":"http://purl.obolibrary.org/obo/UBERON_0001986"},{"id":"T111","span":{"begin":591,"end":593},"obj":"http://purl.obolibrary.org/obo/CLO_0053733"}],"text":"We consider this case an example of neurological manifestations possibly related to COVID-19, characterized by vascular damage predominantly involving microvessels. The absence of pathological confirmation represents a major limitation, but similar MRI patterns [2] and recent pathological correlations seem to support a microangiopathic substrate [8]. Different mechanisms including a systemic procoagulative status and systemic and local inflammatory processes involving the endothelium, most likely via the ACE2 receptor, and eventual immune-mediated vascular injury could be considered [11]. Clinicians should be aware of the possible severe neurological complications in COVID-19 patients and of the role of MRI in their characterization."}

{"project":"LitCovid-sentences","denotations":[{"id":"T88","span":{"begin":0,"end":164},"obj":"Sentence"},{"id":"T89","span":{"begin":165,"end":352},"obj":"Sentence"},{"id":"T90","span":{"begin":353,"end":595},"obj":"Sentence"},{"id":"T91","span":{"begin":596,"end":743},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"We consider this case an example of neurological manifestations possibly related to COVID-19, characterized by vascular damage predominantly involving microvessels. The absence of pathological confirmation represents a major limitation, but similar MRI patterns [2] and recent pathological correlations seem to support a microangiopathic substrate [8]. Different mechanisms including a systemic procoagulative status and systemic and local inflammatory processes involving the endothelium, most likely via the ACE2 receptor, and eventual immune-mediated vascular injury could be considered [11]. Clinicians should be aware of the possible severe neurological complications in COVID-19 patients and of the role of MRI in their characterization."}

{"project":"LitCovid-PubTator","denotations":[{"id":"251","span":{"begin":510,"end":514},"obj":"Gene"},{"id":"252","span":{"begin":685,"end":693},"obj":"Species"},{"id":"253","span":{"begin":84,"end":92},"obj":"Disease"},{"id":"254","span":{"begin":111,"end":126},"obj":"Disease"},{"id":"255","span":{"begin":554,"end":569},"obj":"Disease"},{"id":"256","span":{"begin":646,"end":672},"obj":"Disease"},{"id":"257","span":{"begin":676,"end":684},"obj":"Disease"}],"attributes":[{"id":"A251","pred":"tao:has_database_id","subj":"251","obj":"Gene:59272"},{"id":"A252","pred":"tao:has_database_id","subj":"252","obj":"Tax:9606"},{"id":"A253","pred":"tao:has_database_id","subj":"253","obj":"MESH:C000657245"},{"id":"A254","pred":"tao:has_database_id","subj":"254","obj":"MESH:D000783"},{"id":"A255","pred":"tao:has_database_id","subj":"255","obj":"MESH:D057772"},{"id":"A256","pred":"tao:has_database_id","subj":"256","obj":"MESH:D002493"},{"id":"A257","pred":"tao:has_database_id","subj":"257","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"We consider this case an example of neurological manifestations possibly related to COVID-19, characterized by vascular damage predominantly involving microvessels. The absence of pathological confirmation represents a major limitation, but similar MRI patterns [2] and recent pathological correlations seem to support a microangiopathic substrate [8]. Different mechanisms including a systemic procoagulative status and systemic and local inflammatory processes involving the endothelium, most likely via the ACE2 receptor, and eventual immune-mediated vascular injury could be considered [11]. Clinicians should be aware of the possible severe neurological complications in COVID-19 patients and of the role of MRI in their characterization."}

{"project":"2_test","denotations":[{"id":"33034804-32638079-75886978","span":{"begin":349,"end":350},"obj":"32638079"},{"id":"33034804-32882182-75886979","span":{"begin":591,"end":593},"obj":"32882182"}],"text":"We consider this case an example of neurological manifestations possibly related to COVID-19, characterized by vascular damage predominantly involving microvessels. The absence of pathological confirmation represents a major limitation, but similar MRI patterns [2] and recent pathological correlations seem to support a microangiopathic substrate [8]. Different mechanisms including a systemic procoagulative status and systemic and local inflammatory processes involving the endothelium, most likely via the ACE2 receptor, and eventual immune-mediated vascular injury could be considered [11]. Clinicians should be aware of the possible severe neurological complications in COVID-19 patients and of the role of MRI in their characterization."}