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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 44-59 Body_part denotes Immunoglobulins http://purl.org/sig/ont/fma/fma62871
T2 74-80 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T3 535-549 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T4 675-689 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T5 718-724 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T6 912-927 Body_part denotes immunoglobulins http://purl.org/sig/ont/fma/fma62871
T7 973-979 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T8 1340-1346 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T9 1458-1464 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T10 1508-1516 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T11 1788-1794 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T12 1877-1883 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T13 2512-2525 Body_part denotes bronchiolitis http://purl.org/sig/ont/fma/fma76497
T14 2890-2896 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T15 3165-3173 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T16 4029-4035 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T17 4182-4188 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T18 4290-4296 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T19 4363-4368 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T20 4545-4547 Body_part denotes AG http://purl.org/sig/ont/fma/fma61898
T21 4700-4706 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T22 4731-4737 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T23 4811-4817 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T24 4929-4935 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T25 5502-5512 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T26 5569-5575 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T27 5629-5633 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T28 5825-5831 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T29 6060-6065 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T30 6123-6127 Body_part denotes Cell http://purl.org/sig/ont/fma/fma68646
T31 6792-6796 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T32 6955-6965 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T33 7300-7305 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T34 7745-7751 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T35 7932-7938 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T36 8256-8262 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T37 8293-8299 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T38 8391-8399 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T39 8508-8514 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T40 8577-8582 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670
T41 8953-8967 Body_part denotes immunoglobulin http://purl.org/sig/ont/fma/fma62871
T42 9273-9279 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T43 9384-9390 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T44 9545-9551 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T45 9619-9625 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T46 9696-9702 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T47 9731-9737 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T48 9830-9836 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T49 9944-9950 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T50 10109-10115 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T51 10171-10177 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T52 10606-10612 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T53 10757-10767 Body_part denotes Antibodies http://purl.org/sig/ont/fma/fma62871
T54 10778-10784 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T55 10842-10848 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T56 10907-10913 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T57 11023-11029 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T58 11097-11103 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T59 11420-11428 Body_part denotes antibody http://purl.org/sig/ont/fma/fma62871
T60 11882-11888 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T61 11984-11990 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T62 12007-12013 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T63 12032-12038 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T64 12516-12522 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T65 12615-12621 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T66 13087-13093 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T67 13142-13148 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T68 13429-13436 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T69 13611-13617 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T70 14061-14067 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T71 14165-14171 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T72 14242-14248 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T73 14694-14700 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T74 14744-14750 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T75 15222-15228 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T76 15423-15429 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T77 15548-15554 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T78 15829-15833 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T79 15954-15960 Body_part denotes Plasma http://purl.org/sig/ont/fma/fma62970
T80 16006-16012 Body_part denotes plasma http://purl.org/sig/ont/fma/fma62970
T81 16280-16282 Body_part denotes AG http://purl.org/sig/ont/fma/fma61898
T82 16409-16411 Body_part denotes AG http://purl.org/sig/ont/fma/fma61898

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 4363-4368 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 5825-5831 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T3 8577-8582 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 3-11 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T2 144-152 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T3 878-886 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T4 1071-1089 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T5 1191-1207 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T6 1374-1383 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T7 1602-1612 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T8 2008-2055 Disease denotes Severe acute respiratory syndrome coronavirus-2 http://purl.obolibrary.org/obo/MONDO_0100096
T9 2008-2041 Disease denotes Severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T10 2057-2065 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 2460-2470 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T12 2498-2507 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T13 2512-2525 Disease denotes bronchiolitis http://purl.obolibrary.org/obo/MONDO_0002465
T14 2678-2686 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T15 2691-2699 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T16 3114-3122 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T17 3250-3258 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T18 3477-3485 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T19 3660-3684 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T20 3686-3694 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T21 3785-3793 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T22 4075-4079 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 4227-4235 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 5216-5224 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T25 5261-5269 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T26 5478-5486 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T27 5513-5521 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T28 5840-5850 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T29 5888-5896 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T30 7048-7056 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T31 7633-7641 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T32 7809-7817 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T33 7981-7989 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T34 8008-8016 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T35 8130-8138 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T36 8441-8449 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T37 9052-9060 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T38 9064-9111 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T39 9064-9097 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T40 9667-9675 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T41 9851-9859 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T42 9924-9932 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T43 10309-10317 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T44 10410-10418 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T45 10554-10562 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T46 10638-10646 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T47 10683-10691 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T48 10733-10741 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T49 11073-11081 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T50 11178-11186 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T51 11319-11327 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T52 11329-11353 Disease denotes coronavirus disease 2019 http://purl.obolibrary.org/obo/MONDO_0100096
T53 11462-11470 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T54 11474-11521 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T55 11474-11507 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T56 11622-11630 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T57 12135-12145 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T58 12379-12388 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T59 12753-12761 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T60 12773-12781 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T61 12790-12798 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T62 12944-12952 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T63 12974-12982 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T64 13058-13066 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T65 13190-13198 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T66 13334-13342 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T67 13561-13569 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T68 13701-13709 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T69 13712-13721 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T70 13823-13831 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T71 14032-14042 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T72 14151-14159 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T73 14441-14449 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T74 14456-14465 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T75 14660-14669 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T76 14776-14784 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T77 14833-14841 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T78 14844-14857 Disease denotes infections in http://purl.obolibrary.org/obo/MONDO_0005550
T79 14978-14988 Disease denotes infections http://purl.obolibrary.org/obo/MONDO_0005550
T80 15176-15184 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T81 15375-15383 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T82 15433-15441 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T83 16027-16035 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 74-80 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T2 177-178 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 215-221 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T4 399-405 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T5 652-659 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T6 718-724 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T7 810-811 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T8 973-979 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T9 1008-1009 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T10 1214-1215 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T11 1316-1317 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T12 1340-1346 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T13 1458-1464 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T14 1651-1656 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T15 1788-1794 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T16 1877-1883 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T17 1926-1927 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T18 2192-2197 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T19 2237-2244 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T20 2295-2300 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T21 2313-2318 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T22 2411-2418 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T23 2512-2525 http://purl.obolibrary.org/obo/UBERON_0002186 denotes bronchiolitis
T24 2608-2609 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 2702-2709 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T26 2796-2801 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T27 2890-2896 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T28 3125-3128 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T29 3321-3326 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T30 3637-3638 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31 3724-3730 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T32 3731-3732 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T33 3898-3903 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T34 4029-4035 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T35 4140-4141 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T36 4182-4188 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T37 4290-4296 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T38 4363-4368 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T39 4363-4368 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T40 4582-4588 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T41 4650-4651 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T42 4694-4699 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T43 4700-4706 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T44 4731-4737 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T45 4805-4810 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T46 4811-4817 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T47 4929-4935 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T48 5563-5568 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T49 5569-5575 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T50 5629-5633 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T51 5651-5655 http://purl.obolibrary.org/obo/CLO_0053794 denotes 4, 1
T52 5804-5809 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T53 5974-5980 http://purl.obolibrary.org/obo/CLO_0001929 denotes Berlin
T54 6055-6059 http://purl.obolibrary.org/obo/CLO_0009524 denotes Vero
T55 6055-6059 http://purl.obolibrary.org/obo/CLO_0050515 denotes Vero
T56 6060-6065 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T57 6123-6127 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T58 6205-6210 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T59 6330-6335 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T60 6773-6778 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T61 6792-6796 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T62 6827-6834 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T63 7262-7264 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T64 7294-7305 http://purl.obolibrary.org/obo/CLO_0052043 denotes MRC-5 cells
T65 7294-7305 http://purl.obolibrary.org/obo/CLO_0052044 denotes MRC-5 cells
T66 7294-7305 http://purl.obolibrary.org/obo/CLO_0052045 denotes MRC-5 cells
T67 7342-7344 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T68 7351-7356 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T69 7519-7524 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T70 7745-7751 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T71 7932-7938 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T72 8114-8121 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T73 8207-8213 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T74 8256-8262 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T75 8293-8299 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T76 8438-8439 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T77 8457-8458 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T78 8508-8514 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T79 8571-8582 http://purl.obolibrary.org/obo/UBERON_0000178 denotes whole blood
T80 8571-8582 http://www.ebi.ac.uk/efo/EFO_0000296 denotes whole blood
T81 8708-8709 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T82 8745-8746 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T83 8833-8838 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T84 8916-8921 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T85 9219-9225 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T86 9273-9279 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T87 9384-9390 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T88 9430-9431 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T89 9545-9551 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T90 9602-9609 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T91 9613-9618 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes Human
T92 9619-9625 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T93 9696-9702 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T94 9731-9737 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T95 9769-9775 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T96 9802-9809 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T97 9813-9814 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T98 9830-9836 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T99 9944-9950 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T100 10049-10050 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T101 10086-10093 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Testing
T102 10094-10095 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T103 10109-10115 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T104 10171-10177 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T105 10526-10532 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T106 10606-10612 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T107 10657-10658 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T108 10771-10777 http://purl.obolibrary.org/obo/UBERON_0000473 denotes Tested
T109 10778-10784 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T110 10842-10848 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T111 10907-10913 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T112 10953-10955 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T113 10961-10963 http://purl.obolibrary.org/obo/CLO_0001302 denotes 34
T114 10986-10988 http://purl.obolibrary.org/obo/CLO_0050507 denotes 22
T115 11006-11008 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T116 11023-11029 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T117 11036-11042 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T118 11097-11103 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T119 11210-11211 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T120 11882-11888 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T121 11984-11990 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T122 12007-12013 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T123 12032-12038 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T124 12078-12080 http://purl.obolibrary.org/obo/CLO_0053733 denotes 11
T125 12083-12084 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T126 12155-12158 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T127 12370-12371 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T128 12516-12522 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T129 12615-12621 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T130 12838-12845 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T131 12926-12927 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 13087-13093 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T133 13142-13148 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T134 13263-13269 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T135 13332-13333 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T136 13476-13477 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T137 13493-13497 http://purl.obolibrary.org/obo/UBERON_0000473 denotes test
T138 13611-13617 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T139 14026-14031 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T140 14061-14067 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T141 14165-14171 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T142 14242-14248 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T143 14299-14300 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T144 14683-14690 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T145 14694-14700 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T146 14744-14750 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T147 15222-15228 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T148 15401-15402 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T149 15423-15429 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T150 15528-15529 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T151 15548-15554 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T152 15829-15833 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T153 15898-15903 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T154 15954-15960 http://purl.obolibrary.org/obo/UBERON_0001969 denotes Plasma
T155 16000-16005 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T156 16006-16012 http://purl.obolibrary.org/obo/UBERON_0001969 denotes plasma
T157 16209-16215 http://purl.obolibrary.org/obo/CLO_0001929 denotes Berlin
T158 16476-16481 http://purl.obolibrary.org/obo/CLO_0007079 denotes K., C
T159 16483-16484 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T160 16487-16491 http://purl.obolibrary.org/obo/CLO_0007860 denotes M. R

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T1 472-491 Phenotype denotes immune deficiencies http://purl.obolibrary.org/obo/HP_0002721
T2 1137-1156 Phenotype denotes immune deficiencies http://purl.obolibrary.org/obo/HP_0002721
T3 2498-2507 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T4 2512-2525 Phenotype denotes bronchiolitis http://purl.obolibrary.org/obo/HP_0011950
T5 3594-3613 Phenotype denotes immune deficiencies http://purl.obolibrary.org/obo/HP_0002721

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 1191-1207 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T1 0-115 Sentence denotes No SARS-CoV-2 Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected Before the 2020 Pandemic
T2 117-125 Sentence denotes Abstract
T3 126-134 Sentence denotes Abstract
T4 135-249 Sentence denotes The 2020 SARS-CoV-2 pandemic is caused by a zoonotic coronavirus transmitted to humans, similar to earlier events.
T5 250-417 Sentence denotes Whether the other, seasonally circulating coronaviruses induce cross-reactive, potentially even cross-neutralizing, antibodies to the new species in humans is unclear.
T6 418-651 Sentence denotes The question is particularly relevant for people with immune deficiencies, as their health depends on treatment with immunoglobulin preparations that need to contain neutralizing antibodies against the pathogens in their environment.
T7 652-898 Sentence denotes Testing 54 intravenous immunoglobulin preparations, produced from plasma collected in Europe and the United States, confirmed highly potent neutralization of a seasonal coronavirus; however, no cross-neutralization of the new SARS-CoV-2 was seen.
T8 900-1097 Sentence denotes Intravenous immunoglobulins (IVIG) are produced from thousands of pooled plasma donations, and thus contain a wide variety of antibodies the donors have generated against infectious disease agents.
T9 1098-1208 Sentence denotes IVIG can therefore protect people with immune deficiencies against circulating bacterial and viral infections.
T10 1209-1419 Sentence denotes When a new pathogen emerges, antibodies to the new agent only become detectable in IVIG preparations after a certain proportion of plasma donors have contracted the infection and successfully recovered from it.
T11 1420-1619 Sentence denotes An even higher number of convalescent plasma donors is needed to result in neutralizing antibody (nAb) levels high enough for the resulting IVIG to afford protection against the new infectious agent.
T12 1620-1913 Sentence denotes After the arrival of West Nile virus (WNV) in the United States, for example, it took several years before the prevalence of WNV nAbs reached approximately 0.5% in the plasma donor community, at which point they became detectable in IVIG lots produced from plasma donated in the United States.
T13 1914-2007 Sentence denotes Thereafter, a significant proportion of IVIG lots even reached in vivo protective levels [1].
T14 2008-2187 Sentence denotes Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spread around the globe at unprecedented speed, infecting millions of people within the first 6 months of circulation.
T15 2188-2308 Sentence denotes The virus belongs to the Coronaviridae family of viruses, which contains several species of importance for human health.
T16 2309-2812 Sentence denotes The human coronaviruses (HCoVs) 229E, NL63, OC43, and HKU1 are in circulation as seasonal respiratory viruses that mostly cause self-limiting and mild infections but which can also lead to pneumonia and bronchiolitis [2–4], whereas the Middle East respiratory syndrome coronavirus (MERS-CoV) caused a prolonged outbreak mainly limited to the Arabian Peninsula, and the SARS-CoV and SARS-CoV-2 viruses have established global transmissions chains—the latter 3 associated with significant human mortality.
T17 2813-3033 Sentence denotes Due to the widespread and long-term circulation of HCoVs, and the pooling of plasma from thousands of donors for every lot, IVIGs contain significant levels of HCoV nAb levels, as was shown for example for HCoV-NL63 [5].
T18 3034-3155 Sentence denotes Whether these HCoV antibodies cross-react with, or even neutralize, the related SARS-CoV-2 has not been fully elucidated.
T19 3156-3422 Sentence denotes To date, antibody binding assays have shown some cross-reactivity between different HCoVs and SARS-CoV-2; however, functional and therefore clinically more relevant virus neutralization assays have shown no or only very low levels of cross-reactive antibodies [6–8].
T20 3423-3705 Sentence denotes The question is of significant clinical relevance, as SARS-CoV-2 cross-neutralizing antibodies in IVIGs, if they were present, might afford some protection to people with immune deficiencies and may even represent a treatment option for coronavirus disease 2019 (COVID-19) patients.
T21 3706-3972 Sentence denotes The current study tested a representative number of IVIG lots for nAbs against SARS-CoV-2 and the longer-circulating HCoV-229E, to establish clarity about cross-neutralization of the pandemic virus by antibodies induced by earlier circulating seasonal coronaviruses.
T22 3973-4111 Sentence denotes In addition, results from the ongoing monitoring of the plasma donor community for the development of SARS-COV-2 antibodies are presented.
T23 4113-4120 Sentence denotes METHODS
T24 4122-4139 Sentence denotes IVIG Preparations
T25 4140-4252 Sentence denotes A total of 54 IVIG lots fractionated from plasma collected prior to the circulation of SARS-CoV-2 were analyzed.
T26 4253-4557 Sentence denotes The IVIG lots were manufactured from plasma either donated by plasmapheresis (source) or recovered from whole-blood donations (recovered), in the United States (Gammagard Liquid; Baxter Healthcare Corp.; n = 30) or central Europe, that is Austria, Germany, and Czech Republic (KIOVIG; Baxter AG; n = 24).
T27 4558-4692 Sentence denotes These 54 IVIG lots were tested in 2 independent experiments for nAbs (1 European lot was in a single assay due to volume constraints).
T28 4694-4714 Sentence denotes Human Plasma Samples
T29 4715-4804 Sentence denotes Two prepandemic plasma donations were collected in April and May 2019 by BioLife Austria.
T30 4805-4963 Sentence denotes Human plasma pool samples were generated by the combination of 6 individual donations obtained in the same week at Austrian plasma donation centers (BioLife).
T31 4964-5236 Sentence denotes The pools were assembled from donations collected in week 13 (last week of March; n = 40), week 14 (n = 80), week 15 (n = 80), week 16 (n = 80), week 20 (n = 100), week 24 (n = 80), and week 28 (first week of July; n = 100) of 2020, that is during the SARS-CoV-2 pandemic.
T32 5237-5463 Sentence denotes Cumulative incidence of COVID-19 was calculated from data provided by the Austrian Federal Ministry for Social Affairs, Health, Care and Consumer Protection (www.sozialministerium.at) and Statistics Austria (www.statistik.at).
T33 5465-5512 Sentence denotes Detection of SARS-CoV-2 Neutralizing Antibodies
T34 5513-5753 Sentence denotes SARS-CoV-2 nAb titers were determined in IVIG and human plasma samples that were used undiluted, or prediluted with cell culture medium 1:4, 1:5, 1:10, or 1:20 depending on sample amount available, and then serially diluted in 2-fold steps.
T35 5754-5942 Sentence denotes Equal volumes of sample dilutions were mixed with virus stock at 103.0 tissue culture infectious doses 50% per milliliter (TCID50/mL) SARS-CoV-2 (strain BavPat1/2020, kindly provided by C.
T36 5943-5957 Sentence denotes Drosten and V.
T37 5958-6075 Sentence denotes Corman, Charité Berlin, Germany) and incubated for 150 minutes ± 15 minutes, before titration on Vero cells (Cat. no.
T38 6076-6200 Sentence denotes 84113001, European Collection of Authenticated Cell Cultures, Porton Down, Salisbury, UK) in 8-fold replicates per dilution.
T39 6201-6281 Sentence denotes The virus-induced cytopathic effect was determined after 5–7 days of incubation.
T40 6282-6485 Sentence denotes The reciprocal sample dilution resulting in 50% virus neutralization (NT50) was determined using the Spearman-Kärber formula, and the calculated neutralization titer for 50% of the wells reported as 1:X.
T41 6486-6665 Sentence denotes The detection limits were as follows: <1:0.8 for undiluted, <1:3.1 for 1:4 prediluted, <1:3.9 for 1:5 prediluted, <1:7.7 for 1:10 prediluted, and <1:15.4 for 1:20 prediluted IVIG.
T42 6666-6917 Sentence denotes The neutralization assay (µNT) included several validity criteria, that is confirmatory titration of input virus infectivity, cell viability, and neutralization testing of an internal reference standard, all of which had to comply with defined ranges.
T43 6919-6965 Sentence denotes Detection of HCoV-229E Neutralizing Antibodies
T44 6966-7201 Sentence denotes The neutralization assay for HCoV-229E antibodies is essentially identical to the SARS-CoV-2, where samples were used undiluted or prediluted, then serially diluted in 2-fold steps and mixed 1:2 with 103.0 TCID50/mL HCoV-229E (Cat. no.
T45 7202-7315 Sentence denotes VR-740, American Type Culture Collection [ATCC], Rockville, MD), incubated, and titrated on MRC-5 cells (Cat. no.
T46 7316-7346 Sentence denotes CCL-171, ATCC, Rockville, MD).
T47 7347-7427 Sentence denotes The virus-induced cytopathic effect was determined after 7–9 days of incubation.
T48 7429-7460 Sentence denotes Graphs and Statistical Analysis
T49 7461-7573 Sentence denotes Graphical illustration and statistical analysis (paired t tests) were done using GraphPad Prism v8.1.1 software.
T50 7575-7582 Sentence denotes RESULTS
T51 7583-7916 Sentence denotes The validity, specificity, and reliability of the SARS-CoV-2 neutralization assay used in the current study were demonstrated by the analysis of 100 convalescent plasma donations from polymerase chain reaction (PCR)-confirmed SARS-CoV-2 cases [9] and was the basis for the correlation of function against diverse binding assays [10].
T52 7917-8112 Sentence denotes As controls, 2 plasma samples collected before the emergence of SARS-CoV-2 did not contain SARS-CoV-2 nAbs, as expected, but neutralized HCoV-229E with NT50 values of 1:43 and 1:26, respectively.
T53 8114-8129 Sentence denotes Testing of IVIG
T54 8130-8354 Sentence denotes SARS-CoV-2 nAb titers were below the limit of detection for all 54 IVIG lots tested, irrespective of geographic origin of the plasma (Europe vs United States) and plasma collection modality (recovered vs source) (Figure 1A).
T55 8355-8364 Sentence denotes Figure 1.
T56 8366-8470 Sentence denotes Coronavirus neutralizing antibody titers in IVIG lots (n = 54) against (A) SARS-CoV-2 and (B) HCoV-229E.
T57 8471-8637 Sentence denotes The IVIG lots were manufactured from plasma either donated by plasmapheresis (S), or recovered from whole blood donations (R), in the United States or central Europe.
T58 8638-8777 Sentence denotes Each dot represents the mean of 2 independent experiments, except in (B) from 1 EU-R IVIG lot the titer of a single determination is shown.
T59 8778-8823 Sentence denotes The lines represent the median in each group.
T60 8824-8883 Sentence denotes Paired t tests were used for determination of significance.
T61 8884-9112 Sentence denotes Abbreviation: EU, Europe; HCoV, human coronavirus; IVIG, intravenous immunoglobulin; LOD, limit of detection; µNT50, 50% neutralization titer; R, recovered; S, source; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
T62 9113-9238 Sentence denotes In contrast, HCoV-229E nAb titers between 1:43 and 1:196 (mean = 1:98) were measured for the 54 IVIG lots tested (Figure 1B).
T63 9239-9429 Sentence denotes IVIG lots produced from recovered plasma contained significantly higher levels of nAb to HCoV-229E as compared to IVIG lots produced from source plasma, independent of the geographic origin.
T64 9430-9600 Sentence denotes A significant, although quantitatively minor, difference was also found between IVIG lots manufactured from source plasma collected in either the United States or Europe.
T65 9602-9625 Sentence denotes Testing of Human Plasma
T66 9626-9776 Sentence denotes To evaluate the potential development of SARS-CoV-2 antibodies in the plasma donor community, samples of plasma pools of 6 donations each were tested.
T67 9777-9911 Sentence denotes The use of pools enabled testing of a high amount of plasma donations for SARS-CoV-2 nAbs with the biosafety level-3 functional assay.
T68 9912-10085 Sentence denotes As the mean SARS-CoV-2 µNT50 of plasma donations is rather high (approximately 1:230 [9]) even the nAbs of only 1 positive sample within a pool are detectable in this assay.
T69 10086-10370 Sentence denotes Testing a total of 560 plasma pools of 6 donations each, in total reflective of 3360 plasma donations, from week 13 (ie, last week of March) until week 28 (ie, first week of July) 2020 revealed that most of these pools had SARS-CoV-2 µNT titers below the limit of detection (Table 1).
T70 10371-10446 Sentence denotes The first pool with detectable nAbs to SARS-CoV-2 was collected in week 14.
T71 10447-10509 Sentence denotes Further positive pools were found in weeks 15, 16, 24, and 28.
T72 10510-10722 Sentence denotes Up to 7% of the tested pools showed nAbs to SARS-CoV-2, which indicates that up to 1.17% of the plasma donors were positive for SARS-CoV-2 nAbs at a cumulative incidence of COVID-19 in Austria of 0.21% (Table 1).
T73 10723-10731 Sentence denotes Table 1.
T74 10733-10790 Sentence denotes SARS-CoV-2 Neutralizing Antibodies in Tested Plasma Pools
T75 10791-10803 Sentence denotes Week in 2020
T76 10804-10841 Sentence denotes Parameter 13 14 15 16 20 24 28
T77 10842-10897 Sentence denotes Plasma pools ≥LOD, % 0.0 1.3 1.3 6.3 0.0 5.0 7.0
T78 10898-10941 Sentence denotes µNT50 of plasma pool titers ≥LOD, 1:X n.a.
T79 10943-10973 Sentence denotes 37 5 6, 18, 26, 34, 87 n.a.
T80 10975-11012 Sentence denotes 7, 10, 20, 22 4, 7, 8, 9, 12, 18, 24
T81 11013-11072 Sentence denotes Number of plasma pools tested 40 80 80 80 100 80 100
T82 11073-11166 Sentence denotes SARS-CoV-2 nAb positive plasma donors in Austria, % 0.00 0.21 0.21 1.04 0.00 0.83 1.17
T83 11167-11253 Sentence denotes Cumulative COVID-19 incidence in Austria, %a 0.10 0.14 0.16 0.17 0.18 0.19 0.21
T84 11254-11522 Sentence denotes Abbreviations: µNT50, neutralization titer for 50% of the wells; COVID-19, coronavirus disease 2019; LOD, limit of detection; n.a., not applicable; nAb, neutralizing antibody; PCR, polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
T85 11523-11652 Sentence denotes aSARS-CoV-2 PCR-positive individuals per 100 000 population in Austria are described as cumulative COVID-19 incidence in percent.
T86 11654-11664 Sentence denotes DISCUSSION
T87 11665-11813 Sentence denotes Our analysis of IVIG lots revealed high nAb titers to HCoV-229E (Figure 1B), which confirmed the presence of functionally intact nAbs in these lots.
T88 11814-12021 Sentence denotes It is interesting to note that in IVIG lots produced from recovered plasma significantly higher titers to HCoV-229E were found compared to IVIG lots produced from source plasma, independent of plasma origin.
T89 12022-12082 Sentence denotes Recovered plasma is usually obtained from older donors [11].
T90 12083-12215 Sentence denotes A trend towards increasing probability of HCoV-229E infections with age has been detected in the Scottish [3] and US [4] population.
T91 12216-12363 Sentence denotes Furthermore, higher HCoV-229E–specific nAb titers were found in older study participants (60–85 years) compared to younger ones (21–40 years) [12].
T92 12364-12622 Sentence denotes Thus, a higher infection rate with HCoV-229E in older people and consequently the generation of neutralizing HCoV-229E–specific antibodies in the older plasma donors would explain the higher HCoV-229E titers found in IVIG lots produced from recovered plasma.
T93 12623-12818 Sentence denotes Low levels of cross-neutralizing Abs have earlier been demonstrated between specific pairs of coronaviruses, specifically between SARS-CoV-2 sera and SARS-CoV [6] and SARS-CoV sera and MERS [13].
T94 12819-12999 Sentence denotes In clear contrast, testing the same lots of IVIG that were shown to contain high HCoV-229E nAb titers with a highly specific SARS-CoV-2 µNT did not detect SARS-CoV-2–specific nAbs.
T95 13000-13210 Sentence denotes These results are entirely consistent with the absence of SARS-CoV-2 antibodies in the plasma used for production of these IVIG lots, as this plasma was donated well before the start of the SARS-CoV-2 pandemic.
T96 13211-13618 Sentence denotes The current study, as well as an earlier study that tested 21 IVIG lots (9 Gamunex C, 10 Gammagard Liquid, 2 other) with a SARS-CoV-2-specific enzyme-linked immunosorbent assay (ELISA; receptor-binding domain or spike protein) that was shown to correlate well with a neutralization test [14] revealed the absence of cross-reactive antibodies against SARS-CoV-2 in IVIG lots produced from prepandemic plasma.
T97 13619-13722 Sentence denotes Currently available IVIGs can therefore not be expected to afford protection from SARS-CoV-2 infection.
T98 13723-13998 Sentence denotes Nevertheless, several clinical trials currently investigate IVIG at high dosage in the treatment of COVID-19 patients (clinicaltrials.gov), with the expected benefit attributable to the anti-inflammatory and immunomodulatory capacity of IVIG, rather than an antiviral effect.
T99 13999-14298 Sentence denotes With increasing numbers of human infections, including in the plasma donor community, it is interesting to follow the development of antibodies against SARS-CoV-2 in plasma donations and, after the several months production cycle time between plasma donation and IVIG lot release, also in IVIG lots.
T100 14299-14359 Sentence denotes A longitudinal study on this topic is currently in progress.
T101 14360-14491 Sentence denotes In this context it is noteworthy that the mean nAb titers induced by WNV [1] and SARS-CoV-2 [9] infection are of similar magnitude.
T102 14492-14670 Sentence denotes After the emergence of WNV in the United States, nAb titers became detectable in IVIGs after approximately 0.5% of the population had contracted and recovered from the infection.
T103 14671-14792 Sentence denotes In Austria, testing of plasma pool samples indicated that up to 1.17% of plasma donors were positive for SARS-CoV-2 nAbs.
T104 14793-15136 Sentence denotes Based on the current number of reported SARS-CoV-2 infections in the United States (approximately 4.3 million per 30 July 2020; www.cdc.gov), and an estimated rate of >40% asymptomatic infections [15], more than 7.2 million people in the United States could have been infected already, that is 2.2% of the approximately 330 million population.
T105 15137-15305 Sentence denotes Based on these facts, the detection of SARS-CoV-2 nAbs in IVIG lots produced from US plasma, the major source for fractionation, is expected within the next few months.
T106 15306-15609 Sentence denotes Another, more immediately available possibility for the treatment of COVID-19 is production of a hyper-IVIG from the plasma of COVID-19 convalescent donors (CoVIg-19), and developmental work is currently under way through a large alliance of plasma stakeholders (https://www.covig-19plasmaalliance.org).
T107 15611-15616 Sentence denotes Notes
T108 15617-15633 Sentence denotes Acknowledgments.
T109 15634-15941 Sentence denotes The contributions of the entire Global Pathogen Safety team, most notably Simone Knotzer, Melanie Graf, Jasmin de Silva, Julius Segui (neutralization assays), Veronika Sulzer, Sabrina Brandtner (cell culture), as well as Eva Ha and Alexandra Schlapschy-Danzinger (virus culture) are gratefully acknowledged.
T110 15942-16026 Sentence denotes The team of Plasma Analytics, Takeda, Vienna prepared the human plasma pool samples.
T111 16027-16226 Sentence denotes SARS-CoV-2 was sourced via EVAg (supported by the European Community) and kindly provided by Christian Drosten and Victor Corman (Charité Universitätsmedizin, Institute of Virology, Berlin, Germany).
T112 16227-16245 Sentence denotes Financial support.
T113 16246-16343 Sentence denotes This work was supported by Baxter AG, now part of the Takeda group of companies, Vienna, Austria.
T114 16344-16376 Sentence denotes Potential conflicts of interest.
T115 16377-16472 Sentence denotes Authors are employees of Baxter AG, now part of the Takeda group of companies, Vienna, Austria.
T116 16473-16475 Sentence denotes M.
T117 16476-16482 Sentence denotes K., C.
T118 16483-16489 Sentence denotes A., M.
T119 16490-16492 Sentence denotes R.
T120 16493-16503 Sentence denotes F., and T.
T121 16504-16506 Sentence denotes R.
T122 16507-16537 Sentence denotes K. have Takeda stock interest.
T123 16538-16630 Sentence denotes All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest.
T124 16631-16729 Sentence denotes Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1 3-13 Species denotes SARS-CoV-2 Tax:2697049
12 144-154 Species denotes SARS-CoV-2 Tax:2697049
13 188-199 Species denotes coronavirus Tax:11118
14 215-221 Species denotes humans Tax:9606
15 292-305 Species denotes coronaviruses Tax:11118
16 399-405 Species denotes humans Tax:9606
17 460-466 Species denotes people Tax:9606
18 821-832 Species denotes coronavirus Tax:11118
19 878-888 Species denotes SARS-CoV-2 Tax:2697049
20 179-187 Disease denotes zoonotic MESH:D015047
21 472-491 Disease denotes immune deficiencies MESH:D007153
26 1125-1131 Species denotes people Tax:9606
27 1071-1089 Disease denotes infectious disease MESH:D003141
28 1137-1156 Disease denotes immune deficiencies MESH:D007153
29 1191-1207 Disease denotes viral infections MESH:D001102
34 1641-1656 Species denotes West Nile virus Tax:11082
35 1658-1661 Species denotes WNV Tax:11082
36 1745-1748 Species denotes WNV Tax:11082
37 1374-1383 Disease denotes infection MESH:D007239
55 2008-2055 Species denotes Severe acute respiratory syndrome coronavirus-2 Tax:2697049
56 2057-2067 Species denotes SARS-CoV-2 Tax:2697049
57 2139-2145 Species denotes people Tax:9606
58 2213-2226 Species denotes Coronaviridae Tax:11118
59 2295-2300 Species denotes human Tax:9606
60 2313-2318 Species denotes human Tax:9606
61 2319-2332 Species denotes coronaviruses Tax:11118
62 2545-2600 Species denotes Middle East respiratory syndrome coronavirus (MERS-CoV) Tax:1335626
63 2678-2686 Species denotes SARS-CoV Tax:694009
64 2691-2701 Species denotes SARS-CoV-2 Tax:2697049
65 2796-2801 Species denotes human Tax:9606
66 2341-2345 Species denotes 229E Tax:11137
67 2347-2351 Species denotes NL63 Tax:277944
68 2460-2470 Disease denotes infections MESH:D007239
69 2498-2507 Disease denotes pneumonia MESH:D011014
70 2512-2525 Disease denotes bronchiolitis MESH:D001988
71 2802-2811 Disease denotes mortality MESH:D003643
80 3019-3028 Species denotes HCoV-NL63 Tax:277944
81 3114-3124 Species denotes SARS-CoV-2 Tax:2697049
82 3250-3260 Species denotes SARS-CoV-2 Tax:2697049
83 3477-3487 Species denotes SARS-CoV-2 Tax:2697049
84 3582-3588 Species denotes people Tax:9606
85 3696-3704 Species denotes patients Tax:9606
86 3660-3684 Disease denotes coronavirus disease 2019 MESH:C000657245
87 3686-3694 Disease denotes COVID-19 MESH:C000657245
92 3785-3795 Species denotes SARS-CoV-2 Tax:2697049
93 3823-3832 Species denotes HCoV-229E Tax:11137
94 3958-3971 Species denotes coronaviruses Tax:11118
95 4075-4085 Species denotes SARS-COV-2 Tax:2697049
98 4227-4237 Species denotes SARS-CoV-2 Tax:2697049
99 4622-4626 Chemical denotes nAbs
101 4694-4699 Species denotes Human Tax:9606
105 4805-4810 Species denotes Human Tax:9606
106 5216-5226 Species denotes SARS-CoV-2 Tax:2697049
107 5261-5269 Disease denotes COVID-19 MESH:C000657245
109 5478-5488 Species denotes SARS-CoV-2 Tax:2697049
114 6067-6070 Gene denotes Cat Gene:103237927
115 5513-5523 Species denotes SARS-CoV-2 Tax:2697049
116 5563-5568 Species denotes human Tax:9606
117 5888-5906 Species denotes SARS-CoV-2 (strain Tax:2697049
119 6932-6941 Species denotes HCoV-229E Tax:11137
126 7193-7196 Gene denotes Cat Gene:847
127 7307-7310 Gene denotes Cat Gene:847
128 7048-7058 Species denotes SARS-CoV-2 Tax:2697049
129 7182-7191 Species denotes HCoV-229E Tax:11137
130 6995-7004 Species denotes HCoV-229E Tax:11137
131 7294-7299 CellLine denotes MRC-5 CVCL:0440
138 7633-7643 Species denotes SARS-CoV-2 Tax:2697049
139 7809-7819 Species denotes SARS-CoV-2 Tax:2697049
140 7981-7991 Species denotes SARS-CoV-2 Tax:2697049
141 8008-8018 Species denotes SARS-CoV-2 Tax:2697049
142 8054-8063 Species denotes HCoV-229E Tax:11137
143 8019-8023 Chemical denotes nAbs
145 8130-8140 Species denotes SARS-CoV-2 Tax:2697049
152 8441-8451 Species denotes SARS-CoV-2 Tax:2697049
153 8460-8469 Species denotes HCoV-229E Tax:11137
154 8916-8933 Species denotes human coronavirus Tax:694448
155 9052-9062 Species denotes SARS-CoV-2 Tax:2697049
156 9064-9111 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
157 8366-8377 Species denotes Coronavirus Tax:11118
160 9126-9135 Species denotes HCoV-229E Tax:11137
161 9328-9337 Species denotes HCoV-229E Tax:11137
163 9613-9618 Species denotes Human Tax:9606
169 9851-9861 Species denotes SARS-CoV-2 Tax:2697049
170 9924-9934 Species denotes SARS-CoV-2 Tax:2697049
171 9667-9677 Species denotes SARS-CoV-2 Tax:2697049
172 9862-9866 Chemical denotes nAbs
173 10011-10015 Chemical denotes nAbs
181 10309-10319 Species denotes SARS-CoV-2 Tax:2697049
182 10410-10420 Species denotes SARS-CoV-2 Tax:2697049
183 10554-10564 Species denotes SARS-CoV-2 Tax:2697049
184 10638-10648 Species denotes SARS-CoV-2 Tax:2697049
185 10402-10406 Chemical denotes nAbs
186 10546-10550 Chemical denotes nAbs
187 10683-10691 Disease denotes COVID-19 MESH:C000657245
190 11073-11083 Species denotes SARS-CoV-2 Tax:2697049
191 11178-11186 Disease denotes COVID-19 MESH:C000657245
193 10733-10743 Species denotes SARS-CoV-2 Tax:2697049
197 11462-11472 Species denotes SARS-CoV-2 Tax:2697049
198 11474-11521 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
199 11329-11353 Disease denotes coronavirus disease 2019 MESH:C000657245
202 11529-11534 Species denotes CoV-2 Tax:2697049
203 11622-11630 Disease denotes COVID-19 MESH:C000657245
215 11719-11728 Species denotes HCoV-229E Tax:11137
216 11920-11929 Species denotes HCoV-229E Tax:11137
217 12236-12245 Species denotes HCoV-229E Tax:11137
218 12292-12304 Species denotes participants Tax:9606
219 12399-12408 Species denotes HCoV-229E Tax:11137
220 12418-12424 Species denotes people Tax:9606
221 12555-12564 Species denotes HCoV-229E Tax:11137
222 12473-12482 Species denotes HCoV-229E Tax:11137
223 11794-11798 Chemical denotes nAbs
224 12125-12145 Disease denotes HCoV-229E infections MESH:D003333
225 12379-12388 Disease denotes infection MESH:D007239
231 12717-12730 Species denotes coronaviruses Tax:11118
232 12753-12763 Species denotes SARS-CoV-2 Tax:2697049
233 12773-12781 Species denotes SARS-CoV Tax:694009
234 12790-12798 Species denotes SARS-CoV Tax:694009
235 12808-12812 Disease denotes MERS MESH:D018352
241 12900-12909 Species denotes HCoV-229E Tax:11137
242 12944-12954 Species denotes SARS-CoV-2 Tax:2697049
243 12974-12984 Species denotes SARS-CoV-2 Tax:2697049
244 13190-13200 Species denotes SARS-CoV-2 Tax:2697049
245 13058-13068 Species denotes SARS-CoV-2 Tax:2697049
252 13423-13428 Gene denotes spike Gene:43740568
253 13334-13344 Species denotes SARS-CoV-2 Tax:2697049
254 13561-13571 Species denotes SARS-CoV-2 Tax:2697049
255 13832-13840 Species denotes patients Tax:9606
256 13701-13721 Disease denotes SARS-CoV-2 infection MESH:C000657245
257 13823-13831 Disease denotes COVID-19 MESH:C000657245
272 14026-14031 Species denotes human Tax:9606
273 14151-14161 Species denotes SARS-CoV-2 Tax:2697049
274 14776-14786 Species denotes SARS-CoV-2 Tax:2697049
275 15017-15023 Species denotes people Tax:9606
276 15176-15186 Species denotes SARS-CoV-2 Tax:2697049
277 14429-14432 Species denotes WNV Tax:11082
278 14515-14518 Species denotes WNV Tax:11082
279 14787-14791 Chemical denotes nAbs
280 14032-14042 Disease denotes infections MESH:D007239
281 14441-14465 Disease denotes SARS-CoV-2 [9] infection MESH:C000657245
282 14660-14669 Disease denotes infection MESH:D007239
283 14833-14854 Disease denotes SARS-CoV-2 infections MESH:C000657245
284 14978-14988 Disease denotes infections MESH:D007239
285 15061-15069 Disease denotes infected MESH:D007239
288 15375-15383 Disease denotes COVID-19 MESH:C000657245
289 15433-15441 Disease denotes COVID-19 MESH:C000657245
293 15732-15736 Gene denotes Graf Gene:23092
294 16000-16005 Species denotes human Tax:9606
295 16027-16037 Species denotes SARS-CoV-2 Tax:2697049

2_test

Id Subject Object Predicate Lexical cue
32941626-32652475-61082430 7912-7914 32652475 denotes 10
32941626-31060953-61082431 12078-12080 31060953 denotes 11
32941626-32296837-61082432 12190-12191 32296837 denotes 3
32941626-29427907-61082433 12201-12202 29427907 denotes 4
32941626-32073157-61082434 12359-12361 32073157 denotes 12
32941626-32380903-61082435 12783-12784 32380903 denotes 6
32941626-23583636-61082436 12814-12816 23583636 denotes 13
32941626-32398876-61082437 13499-13501 32398876 denotes 14
32941626-19861071-61082438 14434-14435 19861071 denotes 1
32941626-32491919-61082439 14990-14992 32491919 denotes 15