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{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7545298","sourcedb":"PMC","sourceid":"7545298","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7545298","text":"An important caveat is that the duration of protective immunity after natural infection with SARS-CoV-2 is not currently known, and is one of the most urgent questions for research. Antibodies have been shown to last for at least a few months [3], and T-cell responses are likely to persist for several years more [4,5]. Nevertheless, if people can be reinfected with SARS-CoV-2 within a few years, the virus could become endemic like other seasonal respiratory viruses (e.g. influenza, respiratory syncytial virus, etc.). In such a case, herd immunity might only be achievable through vaccination, which might have to be repeated in order to sustain immunity 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