
PMC:7544943 / 38148-39879
Annnotations
LitCovid-PD-MONDO
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T73 | 145-153 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T74 | 298-306 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T75 | 903-911 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
T76 | 1720-1728 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T176 | 52-53 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T177 | 120-126 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
T178 | 446-447 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T179 | 778-779 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T180 | 876-878 | http://purl.obolibrary.org/obo/CLO_0008933 | denotes | S5 |
T181 | 947-948 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T182 | 1070-1072 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
T183 | 1113-1121 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | actively |
T184 | 1178-1184 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
T185 | 1214-1220 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
T186 | 1452-1458 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
T187 | 1532-1534 | http://purl.obolibrary.org/obo/CLO_0007622 | denotes | MD |
T188 | 1576-1577 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
896 | 1153-1157 | Gene | denotes | Mpro | Gene:8673700 |
897 | 1289-1293 | Gene | denotes | ACE2 | Gene:59272 |
898 | 1400-1404 | Gene | denotes | ACE2 | Gene:59272 |
899 | 1471-1475 | Gene | denotes | Mpro | Gene:8673700 |
900 | 1616-1620 | Gene | denotes | Mpro | Gene:8673700 |
901 | 914-918 | Gene | denotes | Mpro | Gene:8673700 |
902 | 290-294 | Gene | denotes | Mpro | Gene:8673700 |
903 | 87-91 | Gene | denotes | Mpro | Gene:8673700 |
904 | 145-155 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
905 | 298-308 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
906 | 903-913 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
907 | 1720-1730 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
908 | 37-45 | Chemical | denotes | Piperine | MESH:C008922 |
909 | 207-215 | Chemical | denotes | Piperine | MESH:C008922 |
910 | 374-382 | Chemical | denotes | Piperine | MESH:C008922 |
911 | 475-486 | Chemical | denotes | chloroquine | MESH:D002738 |
912 | 488-499 | Chemical | denotes | favipiravir | MESH:C462182 |
913 | 501-519 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
914 | 521-532 | Chemical | denotes | oseltamivir | MESH:D053139 |
915 | 534-544 | Chemical | denotes | remdesivir | MESH:C000606551 |
916 | 549-558 | Chemical | denotes | ribavirin | MESH:D012254 |
917 | 672-680 | Chemical | denotes | Piperine | MESH:C008922 |
918 | 1028-1036 | Chemical | denotes | Piperine | MESH:C008922 |
919 | 1104-1112 | Chemical | denotes | Piperine | MESH:C008922 |
920 | 1192-1200 | Chemical | denotes | Piperine | MESH:C008922 |
921 | 1314-1322 | Chemical | denotes | Piperine | MESH:C008922 |
922 | 1436-1444 | Chemical | denotes | Piperine | MESH:C008922 |
923 | 1561-1569 | Chemical | denotes | Piperine | MESH:C008922 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T25 | 1492-1509 | http://purl.obolibrary.org/obo/GO_0019079 | denotes | viral replication |
T26 | 1492-1509 | http://purl.obolibrary.org/obo/GO_0019058 | denotes | viral replication |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T340 | 0-156 | Sentence | denotes | The comprehensive study reveals that Piperine forms a stable complex with RBD Spro and Mpro and can be considered as an active inhibitor against SARS-CoV-2. |
T341 | 157-341 | Sentence | denotes | From the docking results, it is observed that the Piperine molecule is the best candidate for the inhibition of the RBD Spro and the Mpro of SARS-CoV-2 among the selected 30 molecules. |
T342 | 342-630 | Sentence | denotes | To observe the effectiveness of Piperine over currently used drugs, we carried out the docking study of a few drug molecules such as chloroquine, favipiravir, hydroxychloroquine, oseltamivir, remdesivir and ribavirin using the same docking protocol as followed for the 30 spice molecules. |
T343 | 631-751 | Sentence | denotes | From the docking score, it is found that Piperine performed better as compared to the currently used drugs stated above. |
T344 | 752-946 | Sentence | denotes | The lowest energy pose of a few presently used drugs with their 2D interaction diagram is provided in Supplementary Figures S5 and S6 corresponding to SARS-CoV-2 Mpro and RBD Spro, respectively. |
T345 | 947-1065 | Sentence | denotes | A comparison of the lowest energy dock scores of these drug molecules along with Piperine is also provided in Table 2. |
T346 | 1066-1191 | Sentence | denotes | The MD simulation results reveal that Piperine actively inhibits both the RBD Spro and Mpro by binding to their active sites. |
T347 | 1192-1294 | Sentence | denotes | Piperine binds on the active site of the RBD Spro with those residues by which it interacts with ACE2. |
T348 | 1295-1405 | Sentence | denotes | So, the binding of Piperine on that site may potentially cease the interaction tendency of RBD Spro with ACE2. |
T349 | 1406-1510 | Sentence | denotes | Similarly, the interaction of Piperine on the active site of the Mpro may inhibit its viral replication. |
T350 | 1511-1731 | Sentence | denotes | From the docking and MD results, we conclude that Piperine forms a very stable complex with RBD Spro and Mpro and shows better affinity as compared to the currently used drugs that are mentioned above against SARS-CoV-2. |