PMC:7544943 / 31468-32519 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7544943","sourcedb":"PMC","sourceid":"7544943","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7544943","text":"3.6.3. Radius of gyration (Rg)\nThe root mean square distance between an object and the centre of gravity is defined as the radius of gyration (Rg). The radius of gyration is a measure of the compactness of the protein structure, where higher Rg value is referred to as a less compact structure, and low Rg value is inferred as high compactness that implies more stability. The measured average Rg values of RBD Spro, RBD Spro-Piperine, Mpro and Mpro-Piperine are 1.829 ± 0.008 nm, 1.833 ± 0.010 nm, 2.233 ± 0.012 nm and 2.238 ± 0.013 nm, respectively. From Figure 7(a,b), it is observed that there is a little enhancement in the Rg values of RBD Spro-Piperin, and Mpro-Piperine as compared to RBD Spro and Mpro, which implies to the gain in compactness of the protein structures upon binding to Piperine.\nFigure 7. Radius of gyration plots of (a) RBD Spro (black) and RBD Spro-Piperine (red); (b) Mpro (black) and Mpro-Piperine (blue); (c) Intermolecular hydrogen bonds formed between RBD Spro-Piperine and Mpro-Piperine during 100 ns MD 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