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PMC:7544943 / 30326-31466 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T34 83-91 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T35 216-224 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T36 270-278 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T37 779-786 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T139 270-296 http://purl.obolibrary.org/obo/GO_0043234 denotes proteins and their complex
T140 588-589 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T141 620-621 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T142 761-762 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T143 779-795 http://purl.obolibrary.org/obo/CHEBI_33708 denotes protein residues
T144 924-930 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T145 952-953 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T146 1049-1050 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T147 1099-1100 http://purl.obolibrary.org/obo/CLO_0001021 denotes b

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
721 683-687 Gene denotes Mpro Gene:8673700
722 596-600 Gene denotes Mpro Gene:8673700
723 408-412 Gene denotes Mpro Gene:8673700
724 399-403 Gene denotes Mpro Gene:8673700
725 105-109 Gene denotes Mpro Gene:8673700
726 198-206 Chemical denotes Piperine MESH:C008922
727 302-310 Chemical denotes Piperine MESH:C008922
728 384-397 Chemical denotes Spro-Piperine
729 564-577 Chemical denotes Spro-Piperine
730 875-883 Chemical denotes Piperine MESH:C008922
731 942-950 Chemical denotes Piperine MESH:C008922
735 1102-1106 Gene denotes Mpro Gene:8673700
736 1119-1123 Gene denotes Mpro Gene:8673700
737 1077-1090 Chemical denotes Spro-Piperine

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T263 0-6 Sentence denotes 3.6.2.
T264 8-43 Sentence denotes Root mean square fluctuation (RMSF)
T265 44-225 Sentence denotes The conformational fluctuations of the proteins RBD Spro and Mpro were analysed by observing the residual changes that resulted due to the interaction of Piperine with the proteins.
T266 226-333 Sentence denotes The RMSF plots of the Cα atoms of the viral proteins and their complex with Piperine are shown in Figure 6.
T267 334-539 Sentence denotes From the analysis, it is found that RBD Spro, RBD Spro-Piperine, Mpro and Mpro-Piperine have the average RMSF values 0.099 ± 0.060 nm, 0.097 ± 0.051 nm, 0.119 ± 0.077 nm and 0.120 ± 0.077 nm, respectively.
T268 540-739 Sentence denotes It is observed that RBD Spro-Piperine (Figure 6(a)) and Mpro-Piperine (Figure 6(b)) show similar fluctuations as compared to only RBD Spro and Mpro, which implies to the stability of these compounds.
T269 740-842 Sentence denotes In addition to that, a majority of the protein residues are found to be stabilized within RMSF 0.3 nm.
T270 843-954 Sentence denotes The decrease in fluctuations of Piperine bound to RBD Spro also suggests for the active binding of Piperine (A.
T271 955-986 Sentence denotes Kumar, Choudhir, et al., 2020).
T272 987-996 Sentence denotes Figure 6.
T273 998-1140 Sentence denotes Root mean square fluctuation plots of Cα-atoms of (a) RBD Spro (black) and RBD Spro-Piperine (red); (b) Mpro (black) and Mpro-Piperine (blue).