
PMC:7544943 / 30326-31466
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T34 | 83-91 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T35 | 216-224 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T36 | 270-278 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
T37 | 779-786 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T139 | 270-296 | http://purl.obolibrary.org/obo/GO_0043234 | denotes | proteins and their complex |
T140 | 588-589 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T141 | 620-621 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
T142 | 761-762 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T143 | 779-795 | http://purl.obolibrary.org/obo/CHEBI_33708 | denotes | protein residues |
T144 | 924-930 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
T145 | 952-953 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T146 | 1049-1050 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T147 | 1099-1100 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | b |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
721 | 683-687 | Gene | denotes | Mpro | Gene:8673700 |
722 | 596-600 | Gene | denotes | Mpro | Gene:8673700 |
723 | 408-412 | Gene | denotes | Mpro | Gene:8673700 |
724 | 399-403 | Gene | denotes | Mpro | Gene:8673700 |
725 | 105-109 | Gene | denotes | Mpro | Gene:8673700 |
726 | 198-206 | Chemical | denotes | Piperine | MESH:C008922 |
727 | 302-310 | Chemical | denotes | Piperine | MESH:C008922 |
728 | 384-397 | Chemical | denotes | Spro-Piperine | |
729 | 564-577 | Chemical | denotes | Spro-Piperine | |
730 | 875-883 | Chemical | denotes | Piperine | MESH:C008922 |
731 | 942-950 | Chemical | denotes | Piperine | MESH:C008922 |
735 | 1102-1106 | Gene | denotes | Mpro | Gene:8673700 |
736 | 1119-1123 | Gene | denotes | Mpro | Gene:8673700 |
737 | 1077-1090 | Chemical | denotes | Spro-Piperine |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T263 | 0-6 | Sentence | denotes | 3.6.2. |
T264 | 8-43 | Sentence | denotes | Root mean square fluctuation (RMSF) |
T265 | 44-225 | Sentence | denotes | The conformational fluctuations of the proteins RBD Spro and Mpro were analysed by observing the residual changes that resulted due to the interaction of Piperine with the proteins. |
T266 | 226-333 | Sentence | denotes | The RMSF plots of the Cα atoms of the viral proteins and their complex with Piperine are shown in Figure 6. |
T267 | 334-539 | Sentence | denotes | From the analysis, it is found that RBD Spro, RBD Spro-Piperine, Mpro and Mpro-Piperine have the average RMSF values 0.099 ± 0.060 nm, 0.097 ± 0.051 nm, 0.119 ± 0.077 nm and 0.120 ± 0.077 nm, respectively. |
T268 | 540-739 | Sentence | denotes | It is observed that RBD Spro-Piperine (Figure 6(a)) and Mpro-Piperine (Figure 6(b)) show similar fluctuations as compared to only RBD Spro and Mpro, which implies to the stability of these compounds. |
T269 | 740-842 | Sentence | denotes | In addition to that, a majority of the protein residues are found to be stabilized within RMSF 0.3 nm. |
T270 | 843-954 | Sentence | denotes | The decrease in fluctuations of Piperine bound to RBD Spro also suggests for the active binding of Piperine (A. |
T271 | 955-986 | Sentence | denotes | Kumar, Choudhir, et al., 2020). |
T272 | 987-996 | Sentence | denotes | Figure 6. |
T273 | 998-1140 | Sentence | denotes | Root mean square fluctuation plots of Cα-atoms of (a) RBD Spro (black) and RBD Spro-Piperine (red); (b) Mpro (black) and Mpro-Piperine (blue). |