> top > docs > PMC:7544943 > spans > 19548-21082 > annotations

PMC:7544943 / 19548-21082 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T2 422-427 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T21 422-427 Body_part denotes blood http://purl.org/sig/ont/fma/fma9670

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T87 214-215 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T88 301-302 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T89 369-370 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T90 422-427 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T91 422-427 http://www.ebi.ac.uk/efo/EFO_0000296 denotes blood
T92 480-484 http://purl.obolibrary.org/obo/CLO_0001185 denotes 2018

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
293 6-11 Chemical denotes Water MESH:D014867
296 858-863 Chemical denotes water MESH:D014867
297 1134-1138 Chemical denotes ESOL

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T176 0-4 Sentence denotes 3.3.
T177 6-22 Sentence denotes Water solubility
T178 23-125 Sentence denotes Solubility (Log S) is the measure of homogeneity of the system from the mixture of solute and solvent.
T179 126-272 Sentence denotes It is considered as one of the vital parameters in drug concentration determination for a desired pharmacological response (Savjani et al., 2012).
T180 273-349 Sentence denotes Poor solubility of drugs is a major issue in drug discovery and development.
T181 350-486 Sentence denotes Solubility acts as a driving force to attain high drug concentration in blood for therapeutic effectiveness (Bergström & Larsson, 2018).
T182 487-580 Sentence denotes The drug solubility property of the proposed small molecules was obtained from the SwissADME.
T183 581-900 Sentence denotes The server used three solubility models, such as Ali (Ali et al., 2012), ESOL (Delaney, 2004) and Silicos-IT (http://silicos-it.be.s3-website-eu-west-1.amazonaws.com/software/filter-it/1.0.2/filter-it.html, 2016) that is comprised of different topological methods to check the water solubility of these small molecules.
T184 901-1016 Sentence denotes The plot for solubility of the proposed small molecules based on these three different models is shown in Figure 2.
T185 1017-1218 Sentence denotes The Log S values obtained for the ligand molecules based on these three models are in the range of −1.8 to −3.94 for ESOL method, −1.68 to −4.99 for Ali method and −1.48 to −5.52 for Silicos-IT method.
T186 1219-1326 Sentence denotes The values from different models suggest to the moderately soluble to very soluble nature of the molecules.
T187 1327-1456 Sentence denotes The reference values of Log S for moderately soluble and highly soluble molecules range from −4 to −6 and −2 to −4, respectively.
T188 1457-1534 Sentence denotes The solubility values suggest for the oral administration of these molecules.

2_test

Id Subject Object Predicate Lexical cue
32938313-22830056-56197390 266-270 22830056 denotes 2012
32938313-29421301-56197391 480-484 29421301 denotes 2018
32938313-22196228-56197392 647-651 22196228 denotes 2012
32938313-15154768-56197393 669-673 15154768 denotes 2004