Id |
Subject |
Object |
Predicate |
Lexical cue |
T176 |
0-4 |
Sentence |
denotes |
3.3. |
T177 |
6-22 |
Sentence |
denotes |
Water solubility |
T178 |
23-125 |
Sentence |
denotes |
Solubility (Log S) is the measure of homogeneity of the system from the mixture of solute and solvent. |
T179 |
126-272 |
Sentence |
denotes |
It is considered as one of the vital parameters in drug concentration determination for a desired pharmacological response (Savjani et al., 2012). |
T180 |
273-349 |
Sentence |
denotes |
Poor solubility of drugs is a major issue in drug discovery and development. |
T181 |
350-486 |
Sentence |
denotes |
Solubility acts as a driving force to attain high drug concentration in blood for therapeutic effectiveness (Bergström & Larsson, 2018). |
T182 |
487-580 |
Sentence |
denotes |
The drug solubility property of the proposed small molecules was obtained from the SwissADME. |
T183 |
581-900 |
Sentence |
denotes |
The server used three solubility models, such as Ali (Ali et al., 2012), ESOL (Delaney, 2004) and Silicos-IT (http://silicos-it.be.s3-website-eu-west-1.amazonaws.com/software/filter-it/1.0.2/filter-it.html, 2016) that is comprised of different topological methods to check the water solubility of these small molecules. |
T184 |
901-1016 |
Sentence |
denotes |
The plot for solubility of the proposed small molecules based on these three different models is shown in Figure 2. |
T185 |
1017-1218 |
Sentence |
denotes |
The Log S values obtained for the ligand molecules based on these three models are in the range of −1.8 to −3.94 for ESOL method, −1.68 to −4.99 for Ali method and −1.48 to −5.52 for Silicos-IT method. |
T186 |
1219-1326 |
Sentence |
denotes |
The values from different models suggest to the moderately soluble to very soluble nature of the molecules. |
T187 |
1327-1456 |
Sentence |
denotes |
The reference values of Log S for moderately soluble and highly soluble molecules range from −4 to −6 and −2 to −4, respectively. |
T188 |
1457-1534 |
Sentence |
denotes |
The solubility values suggest for the oral administration of these molecules. |