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PMC:7544943 / 158-1801 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 301-308 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2 433-441 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 4-51 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T3 4-37 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T4 53-61 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 76-94 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T6 284-292 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 310-318 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 339-347 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 365-373 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 689-697 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 929-937 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 1008-1016 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 1626-1634 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 68-69 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 166-167 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 495-500 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T4 716-717 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 990-998 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T6 1051-1054 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7 1327-1329 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T8 1637-1642 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
22 295-300 Gene denotes spike Gene:43740568
23 376-380 Gene denotes Mpro Gene:8673700
24 1032-1036 Gene denotes Mpro Gene:8673700
25 1486-1490 Gene denotes Mpro Gene:8673700
26 1274-1278 Gene denotes Mpro Gene:8673700
27 921-925 Gene denotes Mpro Gene:8673700
28 4-51 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
29 53-63 Species denotes SARS-CoV-2 Tax:2697049
30 284-294 Species denotes SARS-CoV-2 Tax:2697049
31 310-320 Species denotes SARS-CoV-2 Tax:2697049
32 339-349 Species denotes SARS-CoV-2 Tax:2697049
33 365-375 Species denotes SARS-CoV-2 Tax:2697049
34 689-699 Species denotes SARS-CoV-2 Tax:2697049
35 929-939 Species denotes SARS-CoV-2 Tax:2697049
36 1008-1018 Species denotes SARS-CoV-2 Tax:2697049
37 1626-1636 Species denotes SARS-CoV-2 Tax:2697049
38 1042-1050 Chemical denotes Piperine MESH:C008922
39 1156-1164 Chemical denotes Piperine MESH:C008922
40 1200-1208 Chemical denotes Piperine MESH:C008922
41 1247-1255 Chemical denotes Piperine MESH:C008922
42 1459-1467 Chemical denotes Piperine MESH:C008922
43 76-94 Disease denotes infectious disease MESH:D003141

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 112-118 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T2 200-217 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T3 200-217 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T4 236-267 http://purl.obolibrary.org/obo/GO_1900121 denotes inhibiting the receptor-binding
T5 474-487 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6 1446-1455 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T7 0-119 Sentence denotes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel infectious disease that is in rapid growth.
T8 120-195 Sentence denotes Several trials are going on worldwide to find a solution for this pandemic.
T9 196-382 Sentence denotes The viral replication can be blocked by inhibiting the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (SARS-CoV-2 RBD Spro) and the SARS-CoV-2 main protease (SARS-CoV-2 Mpro).
T10 383-501 Sentence denotes The binding of potential small molecules to these proteins can inhibit the replication and transcription of the virus.
T11 502-604 Sentence denotes The spice molecules that are used in our food have antiviral, antifungal and antimicrobial properties.
T12 605-737 Sentence denotes As spice molecules are consumed in the diet, hence its antiviral properties against SARS-CoV-2 will benefit in a significant manner.
T13 738-940 Sentence denotes Therefore, in this work, the molecular docking of 30 selected spice molecules (screened through ADME property) was performed to identify the potential inhibitors for the RBD Spro and Mpro of SARS-CoV-2.
T14 941-1116 Sentence denotes We have found that though all the molecules bind actively with the SARS-CoV-2 RBD Spro and Mpro, but Piperine has the highest binding affinity among the 30 screened molecules.
T15 1117-1227 Sentence denotes Besides, the comparative study between Piperine and currently used drugs show that Piperine is more effective.
T16 1228-1350 Sentence denotes The interaction of Piperine with RBD Spro and Mpro is further validated by the molecular dynamics (MD) simulation studies.
T17 1351-1491 Sentence denotes The free energy landscape and binding free energy results also, support for the stable complex formation of Piperine with RBD Spro and Mpro.
T18 1492-1643 Sentence denotes We anticipate immediate wet-lab experiments and clinical trials in support of this computational study that might help to inhibit the SARS-CoV-2 virus.