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PMC:7544943 / 149-1836 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T1 310-317 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T2 442-450 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T2 13-60 Disease denotes severe acute respiratory syndrome coronavirus 2 http://purl.obolibrary.org/obo/MONDO_0100096
T3 13-46 Disease denotes severe acute respiratory syndrome http://purl.obolibrary.org/obo/MONDO_0005091
T4 62-70 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T5 85-103 Disease denotes infectious disease http://purl.obolibrary.org/obo/MONDO_0005550
T6 293-301 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T7 319-327 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T8 348-356 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T9 374-382 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T10 698-706 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T11 938-946 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T12 1017-1025 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T13 1635-1643 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T1 77-78 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T2 175-176 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T3 504-509 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T4 725-726 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T5 999-1007 http://purl.obolibrary.org/obo/CLO_0001658 denotes actively
T6 1060-1063 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7 1336-1338 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T8 1646-1651 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
22 304-309 Gene denotes spike Gene:43740568
23 385-389 Gene denotes Mpro Gene:8673700
24 1041-1045 Gene denotes Mpro Gene:8673700
25 1495-1499 Gene denotes Mpro Gene:8673700
26 1283-1287 Gene denotes Mpro Gene:8673700
27 930-934 Gene denotes Mpro Gene:8673700
28 13-60 Species denotes severe acute respiratory syndrome coronavirus 2 Tax:2697049
29 62-72 Species denotes SARS-CoV-2 Tax:2697049
30 293-303 Species denotes SARS-CoV-2 Tax:2697049
31 319-329 Species denotes SARS-CoV-2 Tax:2697049
32 348-358 Species denotes SARS-CoV-2 Tax:2697049
33 374-384 Species denotes SARS-CoV-2 Tax:2697049
34 698-708 Species denotes SARS-CoV-2 Tax:2697049
35 938-948 Species denotes SARS-CoV-2 Tax:2697049
36 1017-1027 Species denotes SARS-CoV-2 Tax:2697049
37 1635-1645 Species denotes SARS-CoV-2 Tax:2697049
38 1051-1059 Chemical denotes Piperine MESH:C008922
39 1165-1173 Chemical denotes Piperine MESH:C008922
40 1209-1217 Chemical denotes Piperine MESH:C008922
41 1256-1264 Chemical denotes Piperine MESH:C008922
42 1468-1476 Chemical denotes Piperine MESH:C008922
43 85-103 Disease denotes infectious disease MESH:D003141

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T1 121-127 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T2 209-226 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T3 209-226 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T4 245-276 http://purl.obolibrary.org/obo/GO_1900121 denotes inhibiting the receptor-binding
T5 483-496 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T6 1455-1464 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T6 0-8 Sentence denotes Abstract
T7 9-128 Sentence denotes The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel infectious disease that is in rapid growth.
T8 129-204 Sentence denotes Several trials are going on worldwide to find a solution for this pandemic.
T9 205-391 Sentence denotes The viral replication can be blocked by inhibiting the receptor-binding domain (RBD) of SARS-CoV-2 spike protein (SARS-CoV-2 RBD Spro) and the SARS-CoV-2 main protease (SARS-CoV-2 Mpro).
T10 392-510 Sentence denotes The binding of potential small molecules to these proteins can inhibit the replication and transcription of the virus.
T11 511-613 Sentence denotes The spice molecules that are used in our food have antiviral, antifungal and antimicrobial properties.
T12 614-746 Sentence denotes As spice molecules are consumed in the diet, hence its antiviral properties against SARS-CoV-2 will benefit in a significant manner.
T13 747-949 Sentence denotes Therefore, in this work, the molecular docking of 30 selected spice molecules (screened through ADME property) was performed to identify the potential inhibitors for the RBD Spro and Mpro of SARS-CoV-2.
T14 950-1125 Sentence denotes We have found that though all the molecules bind actively with the SARS-CoV-2 RBD Spro and Mpro, but Piperine has the highest binding affinity among the 30 screened molecules.
T15 1126-1236 Sentence denotes Besides, the comparative study between Piperine and currently used drugs show that Piperine is more effective.
T16 1237-1359 Sentence denotes The interaction of Piperine with RBD Spro and Mpro is further validated by the molecular dynamics (MD) simulation studies.
T17 1360-1500 Sentence denotes The free energy landscape and binding free energy results also, support for the stable complex formation of Piperine with RBD Spro and Mpro.
T18 1501-1652 Sentence denotes We anticipate immediate wet-lab experiments and clinical trials in support of this computational study that might help to inhibit the SARS-CoV-2 virus.
T19 1653-1681 Sentence denotes Communicated by Ramaswamy H.
T20 1682-1687 Sentence denotes Sarma