PMC:7544934 / 24075-24846 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7544934","sourcedb":"PMC","sourceid":"7544934","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7544934","text":"As a reliable COVID-19 vaccine is unlikely to available before the maximal infection of COVID-19 has occurred, it is essential to establish therapeutics for the individuals at moderate and high risk of the disease. So far, anti-viral medication is a major available option for COVID19 patients (Madjid et al., 2020). LDN which showed properties like anti-inflammatory, ERK1/2 inhibitory, and as well virtual docking and simulation data also suggested LDN may disrupt the interaction of ACE2 with RBD. LDN has been gaining credibility in its ability to halt the progression of several diseases without significant side effects when administered in low dosage ( Toljan and Vrooman, 2018; Younger et al., 2014; Low-Dose Naltrexone for Pruritus in Systemic Sclerosis, XXXX ).","tracks":[{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T59","span":{"begin":317,"end":320},"obj":"https://glytoucan.org/Structures/Glycans/G00057MO"},{"id":"T60","span":{"begin":317,"end":320},"obj":"https://glytoucan.org/Structures/Glycans/G31736BK"},{"id":"T61","span":{"begin":451,"end":454},"obj":"https://glytoucan.org/Structures/Glycans/G00057MO"},{"id":"T62","span":{"begin":451,"end":454},"obj":"https://glytoucan.org/Structures/Glycans/G31736BK"},{"id":"T63","span":{"begin":501,"end":504},"obj":"https://glytoucan.org/Structures/Glycans/G00057MO"},{"id":"T64","span":{"begin":501,"end":504},"obj":"https://glytoucan.org/Structures/Glycans/G31736BK"}],"attributes":[{"subj":"T59","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T60","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T61","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T62","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T63","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"},{"subj":"T64","pred":"source","obj":"LitCovid_Glycan-Motif-Structure"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T10","span":{"begin":732,"end":740},"obj":"Phenotype"}],"attributes":[{"id":"A10","pred":"hp_id","subj":"T10","obj":"http://purl.obolibrary.org/obo/HP_0000989"},{"subj":"T10","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"537","span":{"begin":369,"end":375},"obj":"Gene"},{"id":"538","span":{"begin":486,"end":490},"obj":"Gene"},{"id":"539","span":{"begin":285,"end":293},"obj":"Species"},{"id":"540","span":{"begin":717,"end":727},"obj":"Chemical"},{"id":"541","span":{"begin":14,"end":22},"obj":"Disease"},{"id":"542","span":{"begin":75,"end":84},"obj":"Disease"},{"id":"543","span":{"begin":88,"end":96},"obj":"Disease"},{"id":"544","span":{"begin":277,"end":284},"obj":"Disease"},{"id":"545","span":{"begin":732,"end":762},"obj":"Disease"}],"attributes":[{"id":"A537","pred":"tao:has_database_id","subj":"537","obj":"Gene:5595"},{"id":"A538","pred":"tao:has_database_id","subj":"538","obj":"Gene:59272"},{"id":"A539","pred":"tao:has_database_id","subj":"539","obj":"Tax:9606"},{"id":"A540","pred":"tao:has_database_id","subj":"540","obj":"MESH:D009271"},{"id":"A541","pred":"tao:has_database_id","subj":"541","obj":"MESH:C000657245"},{"id":"A542","pred":"tao:has_database_id","subj":"542","obj":"MESH:D007239"},{"id":"A543","pred":"tao:has_database_id","subj":"543","obj":"MESH:C000657245"},{"id":"A544","pred":"tao:has_database_id","subj":"544","obj":"MESH:C000657245"},{"id":"A545","pred":"tao:has_database_id","subj":"545","obj":"MESH:D011537"},{"subj":"537","pred":"source","obj":"LitCovid-PubTator"},{"subj":"538","pred":"source","obj":"LitCovid-PubTator"},{"subj":"539","pred":"source","obj":"LitCovid-PubTator"},{"subj":"540","pred":"source","obj":"LitCovid-PubTator"},{"subj":"541","pred":"source","obj":"LitCovid-PubTator"},{"subj":"542","pred":"source","obj":"LitCovid-PubTator"},{"subj":"543","pred":"source","obj":"LitCovid-PubTator"},{"subj":"544","pred":"source","obj":"LitCovid-PubTator"},{"subj":"545","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T171","span":{"begin":0,"end":214},"obj":"Sentence"},{"id":"T172","span":{"begin":215,"end":316},"obj":"Sentence"},{"id":"T173","span":{"begin":317,"end":500},"obj":"Sentence"},{"id":"T174","span":{"begin":501,"end":771},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T171","pred":"source","obj":"LitCovid-sentences"},{"subj":"T172","pred":"source","obj":"LitCovid-sentences"},{"subj":"T173","pred":"source","obj":"LitCovid-sentences"},{"subj":"T174","pred":"source","obj":"LitCovid-sentences"}]},{"project":"2_test","denotations":[{"id":"32930058-32219363-56195701","span":{"begin":310,"end":314},"obj":"32219363"}],"attributes":[{"subj":"32930058-32219363-56195701","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid_Glycan-Motif-Structure","color":"#a0ec93","default":true},{"id":"LitCovid-PD-HP","color":"#ec93ba"},{"id":"LitCovid-PubTator","color":"#93d4ec"},{"id":"LitCovid-sentences","color":"#ece993"},{"id":"2_test","color":"#cf93ec"}]}]}}