PMC:7543426 / 26827-27971 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T282","span":{"begin":371,"end":376},"obj":"Body_part"},{"id":"T283","span":{"begin":377,"end":383},"obj":"Body_part"},{"id":"T284","span":{"begin":445,"end":450},"obj":"Body_part"},{"id":"T285","span":{"begin":579,"end":584},"obj":"Body_part"},{"id":"T286","span":{"begin":657,"end":662},"obj":"Body_part"},{"id":"T287","span":{"begin":663,"end":670},"obj":"Body_part"},{"id":"T288","span":{"begin":699,"end":710},"obj":"Body_part"},{"id":"T289","span":{"begin":920,"end":924},"obj":"Body_part"}],"attributes":[{"id":"A282","pred":"fma_id","subj":"T282","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A283","pred":"fma_id","subj":"T283","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A284","pred":"fma_id","subj":"T284","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A285","pred":"fma_id","subj":"T285","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A286","pred":"fma_id","subj":"T286","obj":"http://purl.org/sig/ont/fma/fma50801"},{"id":"A287","pred":"fma_id","subj":"T287","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A288","pred":"fma_id","subj":"T288","obj":"http://purl.org/sig/ont/fma/fma66835"},{"id":"A289","pred":"fma_id","subj":"T289","obj":"http://purl.org/sig/ont/fma/fma256135"}],"text":"There were some limitations of our study. Whilst the COVID-19 cases in our study were from a range of age, sex, and comorbidities, we cannot accurately say our findings are fully representative of COVID-19 pathology in the large numbers who have died in Italy. A range of neurological manifestations of COVID-19 have been reported [32]; however, we were unable to obtain brain tissue in our study. A recent [33] histopathological examination of brain specimens obtained from COVID-19 patients who died up to 32 days after symptom onset found only hypoxic changes and no specific brain changes attributable to SARS-CoV-2. Further pathological examination of brain tissues needs to be performed where cytoplasmic viral staining, immunohistochemical, and electron microscope analysis may shed further light on the neuropathological manifestations of COVID-19. It is important that autopsy studies are given priority. Whole-body complete autopsy studies from across a wide range of geographical background, age, ethnic group, and comorbidities [10, 34, 35] are required to define the pathogenesis and the complete spectrum of pathology in COVID-19."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T146","span":{"begin":371,"end":376},"obj":"Body_part"},{"id":"T147","span":{"begin":377,"end":383},"obj":"Body_part"},{"id":"T148","span":{"begin":445,"end":450},"obj":"Body_part"},{"id":"T149","span":{"begin":579,"end":584},"obj":"Body_part"},{"id":"T150","span":{"begin":657,"end":662},"obj":"Body_part"}],"attributes":[{"id":"A146","pred":"uberon_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A147","pred":"uberon_id","subj":"T147","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A148","pred":"uberon_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A149","pred":"uberon_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"A150","pred":"uberon_id","subj":"T150","obj":"http://purl.obolibrary.org/obo/UBERON_0000955"}],"text":"There were some limitations of our study. Whilst the COVID-19 cases in our study were from a range of age, sex, and comorbidities, we cannot accurately say our findings are fully representative of COVID-19 pathology in the large numbers who have died in Italy. A range of neurological manifestations of COVID-19 have been reported [32]; however, we were unable to obtain brain tissue in our study. A recent [33] histopathological examination of brain specimens obtained from COVID-19 patients who died up to 32 days after symptom onset found only hypoxic changes and no specific brain changes attributable to SARS-CoV-2. Further pathological examination of brain tissues needs to be performed where cytoplasmic viral staining, immunohistochemical, and electron microscope analysis may shed further light on the neuropathological manifestations of COVID-19. It is important that autopsy studies are given priority. Whole-body complete autopsy studies from across a wide range of geographical background, age, ethnic group, and comorbidities [10, 34, 35] are required to define the pathogenesis and the complete spectrum of pathology in COVID-19."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T196","span":{"begin":53,"end":61},"obj":"Disease"},{"id":"T197","span":{"begin":197,"end":205},"obj":"Disease"},{"id":"T198","span":{"begin":303,"end":311},"obj":"Disease"},{"id":"T199","span":{"begin":475,"end":483},"obj":"Disease"},{"id":"T200","span":{"begin":609,"end":617},"obj":"Disease"},{"id":"T201","span":{"begin":847,"end":855},"obj":"Disease"},{"id":"T202","span":{"begin":1135,"end":1143},"obj":"Disease"}],"attributes":[{"id":"A196","pred":"mondo_id","subj":"T196","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A197","pred":"mondo_id","subj":"T197","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A198","pred":"mondo_id","subj":"T198","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A199","pred":"mondo_id","subj":"T199","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A200","pred":"mondo_id","subj":"T200","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A201","pred":"mondo_id","subj":"T201","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"id":"A202","pred":"mondo_id","subj":"T202","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"There were some limitations of our study. Whilst the COVID-19 cases in our study were from a range of age, sex, and comorbidities, we cannot accurately say our findings are fully representative of COVID-19 pathology in the large numbers who have died in Italy. A range of neurological manifestations of COVID-19 have been reported [32]; however, we were unable to obtain brain tissue in our study. A recent [33] histopathological examination of brain specimens obtained from COVID-19 patients who died up to 32 days after symptom onset found only hypoxic changes and no specific brain changes attributable to SARS-CoV-2. Further pathological examination of brain tissues needs to be performed where cytoplasmic viral staining, immunohistochemical, and electron microscope analysis may shed further light on the neuropathological manifestations of COVID-19. It is important that autopsy studies are given priority. Whole-body complete autopsy studies from across a wide range of geographical background, age, ethnic group, and comorbidities [10, 34, 35] are required to define the pathogenesis and the complete spectrum of pathology in COVID-19."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T407","span":{"begin":91,"end":92},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T408","span":{"begin":261,"end":262},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T409","span":{"begin":371,"end":376},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T410","span":{"begin":371,"end":376},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T411","span":{"begin":398,"end":399},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T412","span":{"begin":445,"end":450},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T413","span":{"begin":445,"end":450},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T414","span":{"begin":579,"end":584},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T415","span":{"begin":579,"end":584},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T416","span":{"begin":657,"end":662},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"T417","span":{"begin":657,"end":662},"obj":"http://www.ebi.ac.uk/efo/EFO_0000302"},{"id":"T418","span":{"begin":914,"end":924},"obj":"http://purl.obolibrary.org/obo/UBERON_0013702"},{"id":"T419","span":{"begin":962,"end":963},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T420","span":{"begin":1045,"end":1047},"obj":"http://purl.obolibrary.org/obo/CLO_0001302"},{"id":"T421","span":{"begin":1049,"end":1051},"obj":"http://purl.obolibrary.org/obo/CLO_0001000"}],"text":"There were some limitations of our study. Whilst the COVID-19 cases in our study were from a range of age, sex, and comorbidities, we cannot accurately say our findings are fully representative of COVID-19 pathology in the large numbers who have died in Italy. A range of neurological manifestations of COVID-19 have been reported [32]; however, we were unable to obtain brain tissue in our study. A recent [33] histopathological examination of brain specimens obtained from COVID-19 patients who died up to 32 days after symptom onset found only hypoxic changes and no specific brain changes attributable to SARS-CoV-2. Further pathological examination of brain tissues needs to be performed where cytoplasmic viral staining, immunohistochemical, and electron microscope analysis may shed further light on the neuropathological manifestations of COVID-19. It is important that autopsy studies are given priority. Whole-body complete autopsy studies from across a wide range of geographical background, age, ethnic group, and comorbidities [10, 34, 35] are required to define the pathogenesis and the complete spectrum of pathology in COVID-19."}

{"project":"LitCovid-PubTator","denotations":[{"id":"690","span":{"begin":484,"end":492},"obj":"Species"},{"id":"691","span":{"begin":609,"end":619},"obj":"Species"},{"id":"692","span":{"begin":53,"end":61},"obj":"Disease"},{"id":"693","span":{"begin":197,"end":205},"obj":"Disease"},{"id":"694","span":{"begin":246,"end":250},"obj":"Disease"},{"id":"695","span":{"begin":303,"end":311},"obj":"Disease"},{"id":"696","span":{"begin":475,"end":483},"obj":"Disease"},{"id":"697","span":{"begin":497,"end":501},"obj":"Disease"},{"id":"698","span":{"begin":847,"end":855},"obj":"Disease"},{"id":"699","span":{"begin":1135,"end":1143},"obj":"Disease"}],"attributes":[{"id":"A690","pred":"tao:has_database_id","subj":"690","obj":"Tax:9606"},{"id":"A691","pred":"tao:has_database_id","subj":"691","obj":"Tax:2697049"},{"id":"A692","pred":"tao:has_database_id","subj":"692","obj":"MESH:C000657245"},{"id":"A693","pred":"tao:has_database_id","subj":"693","obj":"MESH:C000657245"},{"id":"A694","pred":"tao:has_database_id","subj":"694","obj":"MESH:D003643"},{"id":"A695","pred":"tao:has_database_id","subj":"695","obj":"MESH:C000657245"},{"id":"A696","pred":"tao:has_database_id","subj":"696","obj":"MESH:C000657245"},{"id":"A697","pred":"tao:has_database_id","subj":"697","obj":"MESH:D003643"},{"id":"A698","pred":"tao:has_database_id","subj":"698","obj":"MESH:C000657245"},{"id":"A699","pred":"tao:has_database_id","subj":"699","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"There were some limitations of our study. Whilst the COVID-19 cases in our study were from a range of age, sex, and comorbidities, we cannot accurately say our findings are fully representative of COVID-19 pathology in the large numbers who have died in Italy. A range of neurological manifestations of COVID-19 have been reported [32]; however, we were unable to obtain brain tissue in our study. A recent [33] histopathological examination of brain specimens obtained from COVID-19 patients who died up to 32 days after symptom onset found only hypoxic changes and no specific brain changes attributable to SARS-CoV-2. Further pathological examination of brain tissues needs to be performed where cytoplasmic viral staining, immunohistochemical, and electron microscope analysis may shed further light on the neuropathological manifestations of COVID-19. It is important that autopsy studies are given priority. Whole-body complete autopsy studies from across a wide range of geographical background, age, ethnic group, and comorbidities [10, 34, 35] are required to define the pathogenesis and the complete spectrum of pathology in COVID-19."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T42","span":{"begin":1080,"end":1092},"obj":"http://purl.obolibrary.org/obo/GO_0009405"}],"text":"There were some limitations of our study. Whilst the COVID-19 cases in our study were from a range of age, sex, and comorbidities, we cannot accurately say our findings are fully representative of COVID-19 pathology in the large numbers who have died in Italy. A range of neurological manifestations of COVID-19 have been reported [32]; however, we were unable to obtain brain tissue in our study. A recent [33] histopathological examination of brain specimens obtained from COVID-19 patients who died up to 32 days after symptom onset found only hypoxic changes and no specific brain changes attributable to SARS-CoV-2. Further pathological examination of brain tissues needs to be performed where cytoplasmic viral staining, immunohistochemical, and electron microscope analysis may shed further light on the neuropathological manifestations of COVID-19. It is important that autopsy studies are given priority. Whole-body complete autopsy studies from across a wide range of geographical background, age, ethnic group, and comorbidities [10, 34, 35] are required to define the pathogenesis and the complete spectrum of pathology in COVID-19."}

{"project":"LitCovid-sentences","denotations":[{"id":"T295","span":{"begin":0,"end":41},"obj":"Sentence"},{"id":"T296","span":{"begin":42,"end":260},"obj":"Sentence"},{"id":"T297","span":{"begin":261,"end":397},"obj":"Sentence"},{"id":"T298","span":{"begin":398,"end":620},"obj":"Sentence"},{"id":"T299","span":{"begin":621,"end":856},"obj":"Sentence"},{"id":"T300","span":{"begin":857,"end":913},"obj":"Sentence"},{"id":"T301","span":{"begin":914,"end":1144},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"There were some limitations of our study. Whilst the COVID-19 cases in our study were from a range of age, sex, and comorbidities, we cannot accurately say our findings are fully representative of COVID-19 pathology in the large numbers who have died in Italy. A range of neurological manifestations of COVID-19 have been reported [32]; however, we were unable to obtain brain tissue in our study. A recent [33] histopathological examination of brain specimens obtained from COVID-19 patients who died up to 32 days after symptom onset found only hypoxic changes and no specific brain changes attributable to SARS-CoV-2. Further pathological examination of brain tissues needs to be performed where cytoplasmic viral staining, immunohistochemical, and electron microscope analysis may shed further light on the neuropathological manifestations of COVID-19. It is important that autopsy studies are given priority. Whole-body complete autopsy studies from across a wide range of geographical background, age, ethnic group, and comorbidities [10, 34, 35] are required to define the pathogenesis and the complete spectrum of pathology in COVID-19."}

{"project":"2_test","denotations":[{"id":"32914853-32530583-61098674","span":{"begin":332,"end":334},"obj":"32530583"},{"id":"32914853-32660520-61098675","span":{"begin":408,"end":410},"obj":"32660520"},{"id":"32914853-32217650-61098676","span":{"begin":1045,"end":1047},"obj":"32217650"},{"id":"32914853-32320003-61098677","span":{"begin":1049,"end":1051},"obj":"32320003"}],"text":"There were some limitations of our study. Whilst the COVID-19 cases in our study were from a range of age, sex, and comorbidities, we cannot accurately say our findings are fully representative of COVID-19 pathology in the large numbers who have died in Italy. A range of neurological manifestations of COVID-19 have been reported [32]; however, we were unable to obtain brain tissue in our study. A recent [33] histopathological examination of brain specimens obtained from COVID-19 patients who died up to 32 days after symptom onset found only hypoxic changes and no specific brain changes attributable to SARS-CoV-2. Further pathological examination of brain tissues needs to be performed where cytoplasmic viral staining, immunohistochemical, and electron microscope analysis may shed further light on the neuropathological manifestations of COVID-19. It is important that autopsy studies are given priority. Whole-body complete autopsy studies from across a wide range of geographical background, age, ethnic group, and comorbidities [10, 34, 35] are required to define the pathogenesis and the complete spectrum of pathology in COVID-19."}