PMC:7543426 / 23680-24778
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T253 | 86-91 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T254 | 223-227 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T255 | 269-277 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T256 | 333-344 | Body_part | denotes | lymphocytic | http://purl.org/sig/ont/fma/fma62863 |
| T257 | 409-418 | Body_part | denotes | chemokine | http://purl.org/sig/ont/fma/fma241981 |
| T258 | 471-476 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T259 | 496-509 | Body_part | denotes | blood vessels | http://purl.org/sig/ont/fma/fma63183 |
| T260 | 496-501 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T261 | 767-774 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T262 | 802-806 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T263 | 969-977 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T264 | 978-982 | Body_part | denotes | axis | http://purl.org/sig/ont/fma/fma12520 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T129 | 86-91 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T130 | 223-227 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T131 | 496-509 | Body_part | denotes | blood vessels | http://purl.obolibrary.org/obo/UBERON_0001981 |
| T132 | 496-501 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T133 | 502-509 | Body_part | denotes | vessels | http://purl.obolibrary.org/obo/UBERON_0000055 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T173 | 37-72 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T174 | 43-72 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T175 | 77-99 | Disease | denotes | multiple organ failure | http://purl.obolibrary.org/obo/MONDO_0043726 |
| T176 | 132-140 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T177 | 565-583 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T178 | 934-946 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T179 | 1089-1097 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T359 | 86-91 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T360 | 223-227 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T361 | 223-227 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T362 | 375-376 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T363 | 469-476 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T cells |
| T364 | 496-509 | http://purl.obolibrary.org/obo/UBERON_0001981 | denotes | blood vessels |
| T365 | 496-509 | http://www.ebi.ac.uk/efo/EFO_0000817 | denotes | blood vessels |
| T366 | 537-540 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T367 | 765-766 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T368 | 786-787 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T369 | 800-806 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T370 | 807-813 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T371 | 840-841 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T372 | 948-950 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T373 | 1003-1004 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 617 | 428-433 | Gene | denotes | CXCR3 | Gene:2833 |
| 618 | 688-693 | Gene | denotes | CXCR3 | Gene:2833 |
| 619 | 754-758 | Gene | denotes | CD26 | Gene:1803 |
| 620 | 759-763 | Gene | denotes | DPP4 | Gene:1803 |
| 621 | 963-968 | Gene | denotes | CXCR3 | Gene:2833 |
| 622 | 37-72 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 623 | 77-99 | Disease | denotes | multiple organ failure | MESH:D009102 |
| 624 | 132-140 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 625 | 565-583 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 626 | 934-946 | Disease | denotes | inflammation | MESH:D007249 |
| 627 | 1089-1097 | Disease | denotes | COVID-19 | MESH:C000657245 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T80 | 43-63 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T81 | 565-583 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T34 | 194-209 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T35 | 658-673 | http://purl.obolibrary.org/obo/GO_0006955 | denotes | immune response |
| T36 | 807-826 | http://purl.obolibrary.org/obo/GO_0007165 | denotes | signal transduction |
| T37 | 814-826 | http://purl.obolibrary.org/obo/GO_0009293 | denotes | transduction |
| T38 | 934-946 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T273 | 0-141 | Sentence | denotes | Clinical studies have indicated that acute respiratory distress syndrome and multiple organ failure are features of severe cases of COVID-19. |
| T274 | 142-215 | Sentence | denotes | These are thought to be underpinned by an excessive immune response [19]. |
| T275 | 216-358 | Sentence | denotes | In the lung microenvironment, excessive inflammatory cytokine may be caused by immune-pathological changes linked to lymphocytic infiltration. |
| T276 | 359-589 | Sentence | denotes | We demonstrated a significant upregulation of the chemokine receptor CXCR3, which is not only responsible for T cells extravasating from blood vessels and migration [20], but it has been also implicated in pulmonary fibrosis [21]. |
| T277 | 590-709 | Sentence | denotes | It is thus possible that this is associated with an aberrant type I immune response involving the CXCR3/ligand pathway. |
| T278 | 710-952 | Sentence | denotes | In addition, we found intense expression of CD26/DPP4, a protein that plays a key role in T-cell signal transduction processes as a costimulatory molecule, and its expression level is known to correlate with the severity of inflammation [22]. |
| T279 | 953-1098 | Sentence | denotes | Thus, the CXCR3 cytokine axis could be considered a potential therapeutic target in development of targeted host-directed therapies for COVID-19. |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 32914853-32283152-61098662 | 211-213 | 32283152 | denotes | 19 |
| 32914853-15102366-61098663 | 525-527 | 15102366 | denotes | 20 |
| 32914853-15254596-61098664 | 585-587 | 15254596 | denotes | 21 |
| 32914853-15606609-61098665 | 948-950 | 15606609 | denotes | 22 |