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LitCovid-PD-FMA-UBERON

LitCovid-PD-UBERON

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T141","span":{"begin":1068,"end":1080},"obj":"Disease"},{"id":"T142","span":{"begin":1090,"end":1110},"obj":"Disease"},{"id":"T143","span":{"begin":1349,"end":1360},"obj":"Disease"},{"id":"T144","span":{"begin":1603,"end":1615},"obj":"Disease"},{"id":"T145","span":{"begin":1633,"end":1653},"obj":"Disease"},{"id":"T146","span":{"begin":1728,"end":1742},"obj":"Disease"},{"id":"T148","span":{"begin":2226,"end":2237},"obj":"Disease"},{"id":"T149","span":{"begin":2672,"end":2683},"obj":"Disease"}],"attributes":[{"id":"A141","pred":"mondo_id","subj":"T141","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A142","pred":"mondo_id","subj":"T142","obj":"http://purl.obolibrary.org/obo/MONDO_0000490"},{"id":"A143","pred":"mondo_id","subj":"T143","obj":"http://purl.obolibrary.org/obo/MONDO_0002050"},{"id":"A144","pred":"mondo_id","subj":"T144","obj":"http://purl.obolibrary.org/obo/MONDO_0021166"},{"id":"A145","pred":"mondo_id","subj":"T145","obj":"http://purl.obolibrary.org/obo/MONDO_0000490"},{"id":"A146","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0001343"},{"id":"A147","pred":"mondo_id","subj":"T146","obj":"http://purl.obolibrary.org/obo/MONDO_0005240"},{"id":"A148","pred":"mondo_id","subj":"T148","obj":"http://purl.obolibrary.org/obo/MONDO_0005043"},{"id":"A149","pred":"mondo_id","subj":"T149","obj":"http://purl.obolibrary.org/obo/MONDO_0005043"}],"text":"Liver, Kidney, Spleen, and Bone Marrow Findings\n\nLiver.\nMacroscopic inspection of the liver of all patients showed parenchyma congestion. The main findings at histological level were sinusoidal congestion and extravasation of red blood cells into the space of Disse (Figure 5A1) and in a few cases this was associated with congestion of small veins and hepatocyte necrosis (Figure 5A2 and 5A3) and infiltration (Figure 5A4). Macrovacuolar and microvacuolar steatosis was seen mostly in group 2 patients (Figure 5A1, 5A2, and 5A4, and Table 3).\nFigure 5. Pathological findings in liver and kidney. A1, Liver tissue shows sinusoidal congestion and extravasation of red blood cells into the space of Disse. In some cases, small vein congestion (A2) and hepatic necrosis (A3) were reported. A4, Inflammatory infiltration was observed. A1, A2, and A4, Macrovacuolar and microvacuolar steatosis were observed in the majority of cases. B1, Kidney glomerular endothelial cells were swollen. B2, Fibrin deposit is visible underneath the Bowman capsule. B3, Tubulointerstitial inflammation and (B4) glomerular sclerosis were observed. Abbreviation: H\u0026E, haematoxylin and eosin. Scale bars: A1–A4, and B3, 50 µm; B1, B2, and B4, 14 µm\n\nKidney.\nThe kidneys of all patients generally had normal shape with reduced volume and size. Outer surfaces showed reddish depressions. Histological examination showed interstitial fibrosis, mainly in group 2 patients (Figure 5B1), with swollen glomerular endothelial cells. Fibrin deposits were visible underneath the Bowman capsule (Figure 5B2). Chronic tubular-interstitial inflammation (Figure 5B3) and glomerular sclerosis were observed (Figure 5B4) even in patients without a history of previous kidney disease (Table 3).\n\nSpleen.\nThe spleens of all patients had normal shape but reduced volume and size. The splenic white pulps of all 4 of the group 2 cases showed lymphoid hypoplasia with congested red pulp (Figure 6A1 and 6A2), and Table 3).\nFigure 6. Histology of spleen and bone marrow. A1 and A2, Lymphoid hypoplasia is visible in the splenic white pulp. B1 and B2, Bone marrows tissue shows replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow. Megakaryocyte hyperplasia is observed (arrows). Abbreviation: H\u0026E, haematoxylin and eosin. C1, Macrophages (CD68+) are present in bone marrow tissue. C2, CD68+ cells displaying features of hemophagocytosis (arrow). Scale bars: A1, A2, B2–C2, 7 µm; B1, 100 µm.\n\nBone Marrow.\nMicroscopic analysis of the bone marrows generally showed replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow in group 1 patients (Figure 6B1). Megakaryocytes hyperplasia (Figure 6B2) was seen in 2 patients of group 2 (Table 3). Numerous macrophages (CD68+) were seen and they displayed features of hemophagocytosis (Figure 6C1 and 6C2)."}

LitCovid-PD-CLO

LitCovid-PubTator

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T64","span":{"begin":457,"end":466},"obj":"Phenotype"},{"id":"T65","span":{"begin":751,"end":767},"obj":"Phenotype"},{"id":"T66","span":{"begin":880,"end":889},"obj":"Phenotype"},{"id":"T67","span":{"begin":1090,"end":1110},"obj":"Phenotype"},{"id":"T68","span":{"begin":1349,"end":1360},"obj":"Phenotype"},{"id":"T69","span":{"begin":1633,"end":1653},"obj":"Phenotype"},{"id":"T70","span":{"begin":1728,"end":1742},"obj":"Phenotype"},{"id":"T71","span":{"begin":2401,"end":2417},"obj":"Phenotype"},{"id":"T72","span":{"begin":2812,"end":2828},"obj":"Phenotype"}],"attributes":[{"id":"A64","pred":"hp_id","subj":"T64","obj":"http://purl.obolibrary.org/obo/HP_0001397"},{"id":"A65","pred":"hp_id","subj":"T65","obj":"http://purl.obolibrary.org/obo/HP_0002605"},{"id":"A66","pred":"hp_id","subj":"T66","obj":"http://purl.obolibrary.org/obo/HP_0001397"},{"id":"A67","pred":"hp_id","subj":"T67","obj":"http://purl.obolibrary.org/obo/HP_0000096"},{"id":"A68","pred":"hp_id","subj":"T68","obj":"http://purl.obolibrary.org/obo/HP_0000716"},{"id":"A69","pred":"hp_id","subj":"T69","obj":"http://purl.obolibrary.org/obo/HP_0000096"},{"id":"A70","pred":"hp_id","subj":"T70","obj":"http://purl.obolibrary.org/obo/HP_0000112"},{"id":"A71","pred":"hp_id","subj":"T71","obj":"http://purl.obolibrary.org/obo/HP_0012156"},{"id":"A72","pred":"hp_id","subj":"T72","obj":"http://purl.obolibrary.org/obo/HP_0012156"}],"text":"Liver, Kidney, Spleen, and Bone Marrow Findings\n\nLiver.\nMacroscopic inspection of the liver of all patients showed parenchyma congestion. The main findings at histological level were sinusoidal congestion and extravasation of red blood cells into the space of Disse (Figure 5A1) and in a few cases this was associated with congestion of small veins and hepatocyte necrosis (Figure 5A2 and 5A3) and infiltration (Figure 5A4). Macrovacuolar and microvacuolar steatosis was seen mostly in group 2 patients (Figure 5A1, 5A2, and 5A4, and Table 3).\nFigure 5. Pathological findings in liver and kidney. A1, Liver tissue shows sinusoidal congestion and extravasation of red blood cells into the space of Disse. In some cases, small vein congestion (A2) and hepatic necrosis (A3) were reported. A4, Inflammatory infiltration was observed. A1, A2, and A4, Macrovacuolar and microvacuolar steatosis were observed in the majority of cases. B1, Kidney glomerular endothelial cells were swollen. B2, Fibrin deposit is visible underneath the Bowman capsule. B3, Tubulointerstitial inflammation and (B4) glomerular sclerosis were observed. Abbreviation: H\u0026E, haematoxylin and eosin. Scale bars: A1–A4, and B3, 50 µm; B1, B2, and B4, 14 µm\n\nKidney.\nThe kidneys of all patients generally had normal shape with reduced volume and size. Outer surfaces showed reddish depressions. Histological examination showed interstitial fibrosis, mainly in group 2 patients (Figure 5B1), with swollen glomerular endothelial cells. Fibrin deposits were visible underneath the Bowman capsule (Figure 5B2). Chronic tubular-interstitial inflammation (Figure 5B3) and glomerular sclerosis were observed (Figure 5B4) even in patients without a history of previous kidney disease (Table 3).\n\nSpleen.\nThe spleens of all patients had normal shape but reduced volume and size. The splenic white pulps of all 4 of the group 2 cases showed lymphoid hypoplasia with congested red pulp (Figure 6A1 and 6A2), and Table 3).\nFigure 6. Histology of spleen and bone marrow. A1 and A2, Lymphoid hypoplasia is visible in the splenic white pulp. B1 and B2, Bone marrows tissue shows replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow. Megakaryocyte hyperplasia is observed (arrows). Abbreviation: H\u0026E, haematoxylin and eosin. C1, Macrophages (CD68+) are present in bone marrow tissue. C2, CD68+ cells displaying features of hemophagocytosis (arrow). Scale bars: A1, A2, B2–C2, 7 µm; B1, 100 µm.\n\nBone Marrow.\nMicroscopic analysis of the bone marrows generally showed replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow in group 1 patients (Figure 6B1). Megakaryocytes hyperplasia (Figure 6B2) was seen in 2 patients of group 2 (Table 3). Numerous macrophages (CD68+) were seen and they displayed features of hemophagocytosis (Figure 6C1 and 6C2)."}

LitCovid-PD-GO-BP

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T21","span":{"begin":364,"end":372},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T22","span":{"begin":364,"end":372},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T23","span":{"begin":364,"end":372},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T24","span":{"begin":364,"end":372},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T25","span":{"begin":759,"end":767},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T26","span":{"begin":759,"end":767},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T27","span":{"begin":759,"end":767},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T28","span":{"begin":759,"end":767},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T29","span":{"begin":1068,"end":1080},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T30","span":{"begin":1603,"end":1615},"obj":"http://purl.obolibrary.org/obo/GO_0006954"}],"text":"Liver, Kidney, Spleen, and Bone Marrow Findings\n\nLiver.\nMacroscopic inspection of the liver of all patients showed parenchyma congestion. The main findings at histological level were sinusoidal congestion and extravasation of red blood cells into the space of Disse (Figure 5A1) and in a few cases this was associated with congestion of small veins and hepatocyte necrosis (Figure 5A2 and 5A3) and infiltration (Figure 5A4). Macrovacuolar and microvacuolar steatosis was seen mostly in group 2 patients (Figure 5A1, 5A2, and 5A4, and Table 3).\nFigure 5. Pathological findings in liver and kidney. A1, Liver tissue shows sinusoidal congestion and extravasation of red blood cells into the space of Disse. In some cases, small vein congestion (A2) and hepatic necrosis (A3) were reported. A4, Inflammatory infiltration was observed. A1, A2, and A4, Macrovacuolar and microvacuolar steatosis were observed in the majority of cases. B1, Kidney glomerular endothelial cells were swollen. B2, Fibrin deposit is visible underneath the Bowman capsule. B3, Tubulointerstitial inflammation and (B4) glomerular sclerosis were observed. Abbreviation: H\u0026E, haematoxylin and eosin. Scale bars: A1–A4, and B3, 50 µm; B1, B2, and B4, 14 µm\n\nKidney.\nThe kidneys of all patients generally had normal shape with reduced volume and size. Outer surfaces showed reddish depressions. Histological examination showed interstitial fibrosis, mainly in group 2 patients (Figure 5B1), with swollen glomerular endothelial cells. Fibrin deposits were visible underneath the Bowman capsule (Figure 5B2). Chronic tubular-interstitial inflammation (Figure 5B3) and glomerular sclerosis were observed (Figure 5B4) even in patients without a history of previous kidney disease (Table 3).\n\nSpleen.\nThe spleens of all patients had normal shape but reduced volume and size. The splenic white pulps of all 4 of the group 2 cases showed lymphoid hypoplasia with congested red pulp (Figure 6A1 and 6A2), and Table 3).\nFigure 6. Histology of spleen and bone marrow. A1 and A2, Lymphoid hypoplasia is visible in the splenic white pulp. B1 and B2, Bone marrows tissue shows replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow. Megakaryocyte hyperplasia is observed (arrows). Abbreviation: H\u0026E, haematoxylin and eosin. C1, Macrophages (CD68+) are present in bone marrow tissue. C2, CD68+ cells displaying features of hemophagocytosis (arrow). Scale bars: A1, A2, B2–C2, 7 µm; B1, 100 µm.\n\nBone Marrow.\nMicroscopic analysis of the bone marrows generally showed replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow in group 1 patients (Figure 6B1). Megakaryocytes hyperplasia (Figure 6B2) was seen in 2 patients of group 2 (Table 3). Numerous macrophages (CD68+) were seen and they displayed features of hemophagocytosis (Figure 6C1 and 6C2)."}

LitCovid-PD-GlycoEpitope

{"project":"LitCovid-PD-GlycoEpitope","denotations":[{"id":"T5","span":{"begin":389,"end":392},"obj":"GlycoEpitope"}],"attributes":[{"id":"A5","pred":"glyco_epitope_db_id","subj":"T5","obj":"http://www.glycoepitope.jp/epitopes/AN0387"}],"text":"Liver, Kidney, Spleen, and Bone Marrow Findings\n\nLiver.\nMacroscopic inspection of the liver of all patients showed parenchyma congestion. The main findings at histological level were sinusoidal congestion and extravasation of red blood cells into the space of Disse (Figure 5A1) and in a few cases this was associated with congestion of small veins and hepatocyte necrosis (Figure 5A2 and 5A3) and infiltration (Figure 5A4). Macrovacuolar and microvacuolar steatosis was seen mostly in group 2 patients (Figure 5A1, 5A2, and 5A4, and Table 3).\nFigure 5. Pathological findings in liver and kidney. A1, Liver tissue shows sinusoidal congestion and extravasation of red blood cells into the space of Disse. In some cases, small vein congestion (A2) and hepatic necrosis (A3) were reported. A4, Inflammatory infiltration was observed. A1, A2, and A4, Macrovacuolar and microvacuolar steatosis were observed in the majority of cases. B1, Kidney glomerular endothelial cells were swollen. B2, Fibrin deposit is visible underneath the Bowman capsule. B3, Tubulointerstitial inflammation and (B4) glomerular sclerosis were observed. Abbreviation: H\u0026E, haematoxylin and eosin. Scale bars: A1–A4, and B3, 50 µm; B1, B2, and B4, 14 µm\n\nKidney.\nThe kidneys of all patients generally had normal shape with reduced volume and size. Outer surfaces showed reddish depressions. Histological examination showed interstitial fibrosis, mainly in group 2 patients (Figure 5B1), with swollen glomerular endothelial cells. Fibrin deposits were visible underneath the Bowman capsule (Figure 5B2). Chronic tubular-interstitial inflammation (Figure 5B3) and glomerular sclerosis were observed (Figure 5B4) even in patients without a history of previous kidney disease (Table 3).\n\nSpleen.\nThe spleens of all patients had normal shape but reduced volume and size. The splenic white pulps of all 4 of the group 2 cases showed lymphoid hypoplasia with congested red pulp (Figure 6A1 and 6A2), and Table 3).\nFigure 6. Histology of spleen and bone marrow. A1 and A2, Lymphoid hypoplasia is visible in the splenic white pulp. B1 and B2, Bone marrows tissue shows replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow. Megakaryocyte hyperplasia is observed (arrows). Abbreviation: H\u0026E, haematoxylin and eosin. C1, Macrophages (CD68+) are present in bone marrow tissue. C2, CD68+ cells displaying features of hemophagocytosis (arrow). Scale bars: A1, A2, B2–C2, 7 µm; B1, 100 µm.\n\nBone Marrow.\nMicroscopic analysis of the bone marrows generally showed replacement of red hematopoietic bone marrow with yellow adipocyte-rich marrow in group 1 patients (Figure 6B1). Megakaryocytes hyperplasia (Figure 6B2) was seen in 2 patients of group 2 (Table 3). Numerous macrophages (CD68+) were seen and they displayed features of hemophagocytosis (Figure 6C1 and 6C2)."}

LitCovid-sentences

PMC:7543426 / 17966-20816 JSONTXT

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PMC:7543426 / 17966-20816 JSON TXT