PMC:7538403 / 8224-8963 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7538403","sourcedb":"PMC","sourceid":"7538403","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7538403","text":"Double emulsions containing PLGA and either PVA or P-407 as the nanoparticle stabilizer were spray dried and analyzed for changes in particle size distribution and the resulting nanoparticle yield. The emulsions were either sprayed “as is” or after the addition of matrix excipients: trehalose and mannitol as desiccoprotectants, leucine to increase the dispersibility of the spray-dried powders (19)); VA64 and K30 due to their ability to sterically stabilize drug nanoparticles (20); or the further addition of the nanoparticle stabilizers PVA and P-407 also as matrix excipients. Nanoparticle precipitation from PLGA/PVA or PLGA/P-407 double emulsions by solvent displacement without any additives or spray drying served as the control.","tracks":[{"project":"2_test","denotations":[{"id":"33025335-18040761-27170","span":{"begin":397,"end":399},"obj":"18040761"},{"id":"33025335-26592155-27171","span":{"begin":481,"end":483},"obj":"26592155"}],"attributes":[{"subj":"33025335-18040761-27170","pred":"source","obj":"2_test"},{"subj":"33025335-26592155-27171","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ecb093","default":true}]}]}}