PMC:7538403 / 4057-4832 JSONTXT

{"project":"2_test","denotations":[{"id":"33025335-23357255-27167","span":{"begin":310,"end":312},"obj":"23357255"},{"id":"33025335-22227605-27168","span":{"begin":313,"end":315},"obj":"22227605"}],"text":"Spray dying of water/oil/water (W/O/W) double emulsions allows for the in situ generation of polymeric nanoparticles with hydrophilic cargo while simultaneously embedding them in a stabilizing powder matrix. The concept has been described for batch mode emulsification and conventional spray drying equipment (17,18), but little is known about the factors influencing nanoparticle size and yield. The aim of this study was to investigate whether poly(lactic-co-glycolic acid) (PLGA) nanoparticles can be produced with acceptable yield and particle size distribution by the double emulsion method using scalable methods fit for continuous manufacturing. Different emulsion stabilizers and matrix components were investigated for their influence on nanoparticle size and yield."}