PMC:7538403 / 15006-15882 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7538403","sourcedb":"PMC","sourceid":"7538403","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7538403","text":"An economically interesting nanoparticle yield can be achieved using continuous manufacturing and drying methods. PVA stabilizes emulsion droplets and PLGA nanoparticles during spray drying to achieve a high nanoparticle yield and good particle size distribution, especially in the presence of trehalose and leucine. P-407 is not an effective stabilizer for the double emulsion spray drying method, despite being effective for solvent displacement. Further development work is needed to link the individual processes in a continuous line and to investigate process robustness, scalability, and protein loading efficiency. Further optimization of the emulsion step or use of different emerging emulsion techniques, such as microfluidics, would allow for completely continuous manufacturing of polymeric nanoparticles with an acceptable yield for commercial-scale manufacturing.","tracks":[]}