PMC:7538403 / 10196-11306 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7538403","sourcedb":"PMC","sourceid":"7538403","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7538403","text":"In contrast to the mean particle size, the nanoparticle mass recovery from spray-dried powders is influenced by the choice of matrix (Fig. 2). Spray drying of the emulsion with no further addition of excipients resulted in a nanoparticle yield of 40%. Adding K30 to the emulsion is not beneficial for the nanoparticle yield. Adding mannitol/leucine or VA64 moderately increases the yield to 50–60%. The best result of 79% was obtained when trehalose/leucine were added to the emulsion. A nanoparticle yield of 79% is considerably higher than previously reported for the continuous production of PLGA nanoparticles using focused ultrasound followed by solvent displacement (9). The reported yield may already be economically acceptable when reproduced on a commercial scale.\nFig. 2 Resulting nanoparticle yield after spray drying of PLGA/PVA double emulsions with and without the addition of different matrix excipients. Nanoparticles were isolated from the matrix after reconstitution of the complete batch in purified water, then aggregates were removed by filtration, and the mass was determined after drying","divisions":[{"label":"label","span":{"begin":774,"end":780}}],"tracks":[{"project":"2_test","denotations":[{"id":"33025335-25823648-27173","span":{"begin":673,"end":674},"obj":"25823648"}],"attributes":[{"subj":"33025335-25823648-27173","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#93eca7","default":true}]}]}}