PMC:7537941 / 5794-6838
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T23 | 61-70 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T24 | 114-127 | Body_part | denotes | interleukin-6 | http://purl.org/sig/ont/fma/fma264829 |
| T25 | 176-182 | Body_part | denotes | tissue | http://purl.org/sig/ont/fma/fma9637 |
| T26 | 357-364 | Body_part | denotes | tissues | http://purl.org/sig/ont/fma/fma9637 |
| T27 | 413-417 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T10 | 176-182 | Body_part | denotes | tissue | http://purl.obolibrary.org/obo/UBERON_0000479 |
| T11 | 413-417 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T67 | 0-8 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T68 | 9-18 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T69 | 82-87 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T70 | 340-352 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T71 | 498-533 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T72 | 504-533 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T73 | 535-539 | Disease | denotes | ARDS | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T74 | 615-623 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T75 | 648-660 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T76 | 765-777 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T45 | 114-127 | http://purl.obolibrary.org/obo/PR_000001393 | denotes | interleukin-6 |
| T46 | 158-168 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activators |
| T47 | 234-244 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | Activation |
| T48 | 370-371 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T49 | 413-417 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T50 | 546-548 | http://purl.obolibrary.org/obo/CLO_0050507 | denotes | 22 |
| T51 | 565-575 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T52 | 710-711 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T53 | 782-783 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 156 | 82-103 | Gene | denotes | tumor necrosis factor | Gene:7124 |
| 157 | 105-108 | Gene | denotes | TNF | Gene:7124 |
| 158 | 114-127 | Gene | denotes | interleukin-6 | Gene:3569 |
| 159 | 129-133 | Gene | denotes | IL-6 | Gene:3569 |
| 160 | 176-189 | Gene | denotes | tissue factor | Gene:2152 |
| 161 | 191-193 | Gene | denotes | TF | Gene:2152 |
| 162 | 594-602 | Species | denotes | patients | Tax:9606 |
| 163 | 0-18 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
| 164 | 340-352 | Disease | denotes | inflammation | MESH:D007249 |
| 165 | 498-533 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 166 | 535-539 | Disease | denotes | ARDS | MESH:D012128 |
| 167 | 615-623 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 168 | 648-660 | Disease | denotes | inflammation | MESH:D007249 |
| 169 | 765-777 | Disease | denotes | inflammation | MESH:D007249 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T23 | 88-96 | http://purl.obolibrary.org/obo/GO_0070265 | denotes | necrosis |
| T24 | 88-96 | http://purl.obolibrary.org/obo/GO_0019835 | denotes | necrosis |
| T25 | 88-96 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | necrosis |
| T26 | 88-96 | http://purl.obolibrary.org/obo/GO_0001906 | denotes | necrosis |
| T27 | 205-216 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T28 | 234-263 | http://purl.obolibrary.org/obo/GO_0050820 | denotes | Activation of the coagulation |
| T29 | 252-263 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T30 | 340-352 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T31 | 465-473 | http://purl.obolibrary.org/obo/GO_0015297 | denotes | exchange |
| T32 | 565-590 | http://purl.obolibrary.org/obo/GO_0050820 | denotes | activation of coagulation |
| T33 | 579-590 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T34 | 648-660 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T35 | 765-777 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T36 | 897-905 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | clotting |
| T37 | 917-928 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T38 | 949-971 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
MyTest
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33004529-32361250-29392984 | 136-138 | 32361250 | denotes | 16 |
| 33004529-2050700-29392985 | 226-228 | 2050700 | denotes | 17 |
| 33004529-11722403-29392985 | 226-228 | 11722403 | denotes | 17 |
| 33004529-15115872-29392986 | 475-477 | 15115872 | denotes | 20 |
| 33004529-22417886-29392987 | 542-544 | 22417886 | denotes | 21 |
| 33004529-15891319-29392988 | 546-548 | 15891319 | denotes | 22 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T32 | 9-18 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T33 | 82-87 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T34 | 504-524 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T35 | 1022-1043 | Phenotype | denotes | pulmonary infiltrates | http://purl.obolibrary.org/obo/HP_0002113 |
2_test
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 33004529-32361250-29392984 | 136-138 | 32361250 | denotes | 16 |
| 33004529-2050700-29392985 | 226-228 | 2050700 | denotes | 17 |
| 33004529-11722403-29392985 | 226-228 | 11722403 | denotes | 17 |
| 33004529-15115872-29392986 | 475-477 | 15115872 | denotes | 20 |
| 33004529-22417886-29392987 | 542-544 | 22417886 | denotes | 21 |
| 33004529-15891319-29392988 | 546-548 | 15891319 | denotes | 22 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T37 | 0-233 | Sentence | denotes | COVID-19 pneumonia is characterised by increases in multiple cytokines, including tumor necrosis factor (TNF) and interleukin-6 (IL-6) [16], which are potent activators of the tissue factor (TF)-dependent coagulation cascade [17–19]. |
| T38 | 234-550 | Sentence | denotes | Activation of the coagulation system is known to be pro-inflammatory and could drive further increases in inflammation; in tissues with a delicate architecture such as the distal lung, this can be highly detrimental, impairing gas exchange [20] and culminating in acute respiratory distress syndrome (ARDS) [21, 22]. |
| T39 | 551-801 | Sentence | denotes | The extensive activation of coagulation in patients with severe COVID-19 could stimulate further inflammation via the mechanisms described below, resulting in a positive feedback loop that maintains high levels of inflammation for a prolonged period. |
| T40 | 802-1044 | Sentence | denotes | Hence, effective anticoagulation strategies may prevent complications associated with aberrant clotting, attenuate coagulation-induced exaggerated inflammatory responses and potentially reduce the severity and extent of pulmonary infiltrates. |