PMC:7537941 / 34107-35479
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T163 | 126-130 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T164 | 300-304 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
| T165 | 865-869 | Body_part | denotes | body | http://purl.org/sig/ont/fma/fma256135 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T55 | 126-130 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
| T56 | 300-304 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T220 | 112-121 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T221 | 131-137 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T222 | 237-249 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T223 | 278-287 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T224 | 305-311 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T225 | 498-507 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T226 | 599-607 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T227 | 636-651 | Disease | denotes | hypercoagulable | http://purl.obolibrary.org/obo/MONDO_0002305 |
| T228 | 987-995 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T229 | 996-1005 | Disease | denotes | pneumonia | http://purl.obolibrary.org/obo/MONDO_0005249 |
| T230 | 1057-1069 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T231 | 1081-1084 | Disease | denotes | VTE | http://purl.obolibrary.org/obo/MONDO_0005399 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T334 | 126-130 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T335 | 126-130 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T336 | 300-304 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T337 | 300-304 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T338 | 422-427 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T339 | 625-626 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T340 | 1136-1137 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1141 | 422-427 | Species | denotes | human | Tax:9606 |
| 1142 | 973-981 | Species | denotes | patients | Tax:9606 |
| 1143 | 112-121 | Disease | denotes | pneumonia | MESH:D011014 |
| 1144 | 126-137 | Disease | denotes | lung injury | MESH:D055370 |
| 1145 | 237-249 | Disease | denotes | inflammation | MESH:D007249 |
| 1146 | 268-287 | Disease | denotes | pulmonary infection | MESH:D012141 |
| 1147 | 289-295 | Disease | denotes | sepsis | MESH:D018805 |
| 1148 | 300-311 | Disease | denotes | lung injury | MESH:D055370 |
| 1149 | 498-507 | Disease | denotes | pneumonia | MESH:D011014 |
| 1150 | 515-521 | Disease | denotes | sepsis | MESH:D018805 |
| 1151 | 561-570 | Disease | denotes | mortality | MESH:D003643 |
| 1152 | 599-607 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1153 | 696-725 | Disease | denotes | macrothrombi and microthrombi | |
| 1154 | 901-907 | Disease | denotes | sepsis | MESH:D018805 |
| 1155 | 987-1005 | Disease | denotes | COVID-19 pneumonia | MESH:C000657245 |
| 1156 | 1057-1069 | Disease | denotes | inflammation | MESH:D007249 |
| 1157 | 1081-1084 | Disease | denotes | VTE | MESH:D054556 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T163 | 75-86 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T164 | 87-98 | http://purl.obolibrary.org/obo/GO_0004175 | denotes | proteinases |
| T165 | 221-232 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T166 | 237-249 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T167 | 395-406 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translation |
| T168 | 829-840 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T169 | 885-896 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T170 | 1034-1045 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulation |
| T171 | 1057-1069 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T102 | 112-121 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T103 | 268-287 | Phenotype | denotes | pulmonary infection | http://purl.obolibrary.org/obo/HP_0006532 |
| T104 | 289-295 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T105 | 498-507 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
| T106 | 515-521 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T107 | 901-907 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T108 | 996-1005 | Phenotype | denotes | pneumonia | http://purl.obolibrary.org/obo/HP_0002090 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T200 | 0-11 | Sentence | denotes | Conclusions |
| T201 | 12-312 | Sentence | denotes | Preclinical studies have shown beneficial effects of targeting coagulation proteinases in models of pneumonia and lung injury and have added significant knowledge to the understanding of the crosstalk between coagulation and inflammation in the context of pulmonary infection, sepsis and lung injury. |
| T202 | 313-571 | Sentence | denotes | Importantly, these preclinical studies have limitations that affect the potential translation of findings to human disease, and previous clinical trials of endogenous anticoagulants in pneumonia and in sepsis have mostly failed to show benefits on mortality. |
| T203 | 572-850 | Sentence | denotes | However, in the context of COVID-19, the evidence of a profound hypercoagulable state with pathogenic contributions of both macrothrombi and microthrombi in severe disease suggest there is an improved risk/benefit ratio in targeting specific aspects of the coagulation pathways. |
| T204 | 851-1135 | Sentence | denotes | The extensive body of research on coagulation and sepsis provides important background for the design of future trials in patients with COVID-19 pneumonia to assess whether targeting coagulation can reduce inflammation as well as VTE and microthrombi, and potentially affect survival. |
| T205 | 1136-1372 | Sentence | denotes | A large armamentarium of potentially beneficial agents exists, and well-designed randomised clinical trials are now needed to investigate the wide range of anticoagulant and anti-fibrinolytic therapies to determine the optimal strategy. |