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PMC:7537941 / 11210-13369 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T60 316-322 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T61 442-454 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T62 478-495 Body_part denotes endothelial cells http://purl.org/sig/ont/fma/fma66772
T63 490-495 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T64 500-509 Body_part denotes platelets http://purl.org/sig/ont/fma/fma62851
T65 803-807 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T66 1023-1031 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050
T67 1446-1453 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T68 1686-1693 Body_part denotes heparin http://purl.org/sig/ont/fma/fma82839
T69 1755-1761 Body_part denotes Tissue http://purl.org/sig/ont/fma/fma9637
T70 2079-2088 Body_part denotes capillary http://purl.org/sig/ont/fma/fma63194

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T23 316-322 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T24 803-807 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T25 1755-1761 Body_part denotes Tissue http://purl.obolibrary.org/obo/UBERON_0000479
T26 2079-2088 Body_part denotes capillary http://purl.obolibrary.org/obo/UBERON_0001982

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T101 121-130 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T102 808-820 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T103 1053-1061 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T104 1062-1071 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T105 1398-1410 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T106 1617-1626 Disease denotes pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T107 1816-1825 Disease denotes Pneumonia http://purl.obolibrary.org/obo/MONDO_0005249
T108 2114-2126 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T116 304-314 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T117 358-359 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T118 403-411 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T119 478-495 http://purl.obolibrary.org/obo/CL_0000115 denotes endothelial cells
T120 640-645 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T121 646-653 http://purl.obolibrary.org/obo/NCBITaxon_9443 denotes primate
T122 705-706 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T123 803-807 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T124 803-807 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T125 847-849 http://purl.obolibrary.org/obo/CLO_0001000 denotes 35
T126 851-853 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T127 856-857 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T128 897-902 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T129 1076-1077 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T130 1282-1283 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T131 1517-1518 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T132 1845-1847 http://purl.obolibrary.org/obo/CLO_0053794 denotes 41

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
297 0-2 Gene denotes TF Gene:2152
337 316-347 Gene denotes Tissue factor pathway inhibitor Gene:7035
338 349-353 Gene denotes TFPI Gene:7035
339 416-424 Gene denotes thrombin Gene:2147
340 542-551 Gene denotes factor Xa Gene:2159
341 560-564 Gene denotes TFPI Gene:7035
342 780-782 Gene denotes TF Gene:2152
343 903-907 Gene denotes TFPI Gene:7035
344 987-991 Gene denotes IL-6 Gene:3569
345 1755-1786 Gene denotes Tissue Factor Pathway Inhibitor Gene:7035
346 1946-1950 Gene denotes TFPI Gene:7035
347 2035-2037 Gene denotes TF Gene:2152
348 732-734 Gene denotes TF Gene:2152
349 690-692 Gene denotes TF Gene:2152
350 392-394 Gene denotes TF Gene:2152
351 156-158 Gene denotes TF Gene:2152
352 22-24 Gene denotes TF Gene:2152
353 100-108 Species denotes patients Tax:9606
354 640-645 Species denotes human Tax:9606
355 897-902 Species denotes human Tax:9606
356 931-939 Species denotes patients Tax:9606
357 1249-1257 Species denotes patients Tax:9606
358 1577-1585 Species denotes patients Tax:9606
359 1891-1899 Species denotes patients Tax:9606
360 1446-1453 Chemical denotes heparin MESH:D006493
361 1686-1693 Chemical denotes heparin MESH:D006493
362 121-130 Disease denotes pneumonia MESH:D011014
363 664-676 Disease denotes endotoxaemia
364 803-820 Disease denotes lung inflammation MESH:D011014
365 952-958 Disease denotes sepsis MESH:D018805
366 1053-1071 Disease denotes COVID-19 pneumonia MESH:C000657245
367 1211-1217 Disease denotes Sepsis MESH:D018805
368 1270-1276 Disease denotes sepsis MESH:D018805
369 1358-1367 Disease denotes mortality MESH:D003643
370 1398-1410 Disease denotes inflammation MESH:D007249
371 1498-1506 Disease denotes bleeding MESH:D006470
372 1617-1626 Disease denotes pneumonia MESH:D011014
373 1816-1825 Disease denotes Pneumonia MESH:D011014
374 1995-2001 Disease denotes sepsis MESH:D018805
375 2114-2126 Disease denotes inflammation MESH:D007249

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T76 174-185 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T77 292-303 http://purl.obolibrary.org/obo/GO_0050817 denotes coagulation
T78 808-820 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T79 1398-1410 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T80 2114-2126 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation

MyTest

Id Subject Object Predicate Lexical cue
33004529-11734456-29392999 847-849 11734456 denotes 35
33004529-12034563-29393000 851-853 12034563 denotes 36
33004529-11700399-29393001 1119-1121 11700399 denotes 37
33004529-32253759-29393002 1123-1125 32253759 denotes 38
33004529-12851279-29393003 1412-1414 12851279 denotes 39
33004529-19284881-29393004 1714-1716 19284881 denotes 40
33004529-21297074-29393005 1845-1847 21297074 denotes 41

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T49 121-130 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T50 952-958 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T51 1062-1071 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T52 1211-1217 Phenotype denotes Sepsis http://purl.obolibrary.org/obo/HP_0100806
T53 1270-1276 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806
T54 1617-1626 Phenotype denotes pneumonia http://purl.obolibrary.org/obo/HP_0002090
T55 1816-1825 Phenotype denotes Pneumonia http://purl.obolibrary.org/obo/HP_0002090
T56 1995-2001 Phenotype denotes sepsis http://purl.obolibrary.org/obo/HP_0100806

2_test

Id Subject Object Predicate Lexical cue
33004529-11734456-29392999 847-849 11734456 denotes 35
33004529-12034563-29393000 851-853 12034563 denotes 36
33004529-11700399-29393001 1119-1121 11700399 denotes 37
33004529-32253759-29393002 1123-1125 32253759 denotes 38
33004529-12851279-29393003 1412-1414 12851279 denotes 39
33004529-19284881-29393004 1714-1716 19284881 denotes 40
33004529-21297074-29393005 1845-1847 21297074 denotes 41

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T64 0-21 Sentence denotes TF pathway inhibitors
T65 22-315 Sentence denotes TF and factor VIIa levels are elevated in the bronchoalveolar lavage fluid of patients with severe pneumonia, and the central role of TF for initiating coagulation makes it an attractive target for therapeutic intervention against the potential negative consequences of coagulation activation.
T66 316-436 Sentence denotes Tissue factor pathway inhibitor (TFPI) is a central endogenous regulator of TF pathway activity and thrombin generation.
T67 437-552 Sentence denotes This glycoprotein is mainly expressed by endothelial cells and platelets and acts by directly inhibiting factor Xa.
T68 553-620 Sentence denotes The Xa-TFPI complex subsequently also inhibits the TF-VIIa complex.
T69 621-855 Sentence denotes In preclinical non-human primate models of endotoxaemia, blockade of TF-VIIa, using a competitive inhibitor of TF (site-inactivated factor VIIa), inhibits the TF pathway and reduces lung inflammation and deposition of fibrin [35, 36].
T70 856-1127 Sentence denotes A phase II clinical trial of recombinant human TFPI (rhTFPI; Tifacogin) in patients with severe sepsis decreased concentrations of IL-6, an important pro-inflammatory cytokine that is increased in COVID-19 pneumonia and a major target in ongoing clinical trials [37, 38].
T71 1128-1416 Sentence denotes However, in the Optimised Phase III Tifacogin (rTFPI) in Multicenter International Sepsis Trial (OPTIMIST phase III) for patients with severe sepsis with a high international normalised ratio (≥1.2), rhTFPI did not improve 28-day mortality, despite reducing evidence of inflammation [39].
T72 1417-1718 Sentence denotes Administration of rhTFPI and heparin concomitantly was associated with increased bleeding, although a post hoc analysis did suggest rhTFPI improved survival in patients with severe community-acquired pneumonia (CAP) for whom the microbiological aetiology was known and heparin had not been given [40].
T73 1719-1936 Sentence denotes However, the subsequent Recombinant Tissue Factor Pathway Inhibitor in Severe Community-Acquired Pneumonia (CAPTIVATE) trial [41] did not demonstrate improved survival for patients with severe CAP treated with rhTFPI.
T74 1937-2159 Sentence denotes Although TFPI was largely disappointing in the setting of sepsis, the advantages of targeting the TF pathway in preventing the development of capillary microthrombi, as well as inflammation, might outweigh potential risks.