PMC:7537531 / 9748-10589 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T50","span":{"begin":47,"end":52},"obj":"Body_part"},{"id":"T51","span":{"begin":112,"end":115},"obj":"Body_part"},{"id":"T52","span":{"begin":322,"end":326},"obj":"Body_part"},{"id":"T53","span":{"begin":327,"end":333},"obj":"Body_part"},{"id":"T54","span":{"begin":344,"end":347},"obj":"Body_part"},{"id":"T55","span":{"begin":396,"end":400},"obj":"Body_part"},{"id":"T56","span":{"begin":401,"end":407},"obj":"Body_part"},{"id":"T57","span":{"begin":532,"end":536},"obj":"Body_part"},{"id":"T58","span":{"begin":553,"end":558},"obj":"Body_part"},{"id":"T59","span":{"begin":586,"end":589},"obj":"Body_part"},{"id":"T60","span":{"begin":617,"end":622},"obj":"Body_part"}],"attributes":[{"id":"A50","pred":"fma_id","subj":"T50","obj":"http://purl.org/sig/ont/fma/fma68877"},{"id":"A51","pred":"fma_id","subj":"T51","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A52","pred":"fma_id","subj":"T52","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A53","pred":"fma_id","subj":"T53","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A54","pred":"fma_id","subj":"T54","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A55","pred":"fma_id","subj":"T55","obj":"http://purl.org/sig/ont/fma/fma7195"},{"id":"A56","pred":"fma_id","subj":"T56","obj":"http://purl.org/sig/ont/fma/fma9637"},{"id":"A57","pred":"fma_id","subj":"T57","obj":"http://purl.org/sig/ont/fma/fma9712"},{"id":"A58","pred":"fma_id","subj":"T58","obj":"http://purl.org/sig/ont/fma/fma9670"},{"id":"A59","pred":"fma_id","subj":"T59","obj":"http://purl.org/sig/ont/fma/fma67095"},{"id":"A60","pred":"fma_id","subj":"T60","obj":"http://purl.org/sig/ont/fma/fma9670"}],"text":"In addition, we determined viral titres in the lungs of infected animals (Figure S1). Our assays confirmed high RNA copy numbers and corresponding viral titres at early time points after infection followed by a rapid but incomplete clearance of the virus infection until 14 dpi. With titres of up to 5 × 107 pfu per 50 mg lung tissue and viral RNA copies in the range of up to 1 × 107 per 2.5 mg lung tissue at early time points after infection, we concluded that Chinese hamsters are highly susceptible to SARS‐CoV‐2. On the other hand, virus loads in blood samples were below 1 × 102 RNA copies per 2.5 µl of whole blood (15.6 ± 29.8 SD) at all time points, indicating lack of significant viremia and systemic infection (Figure 1e). These observations match findings from other animal models for emerging coronaviruses (Yuan et al., 2020)."}

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":322,"end":326},"obj":"Body_part"},{"id":"T22","span":{"begin":327,"end":333},"obj":"Body_part"},{"id":"T23","span":{"begin":396,"end":400},"obj":"Body_part"},{"id":"T24","span":{"begin":401,"end":407},"obj":"Body_part"},{"id":"T25","span":{"begin":532,"end":536},"obj":"Body_part"},{"id":"T26","span":{"begin":553,"end":558},"obj":"Body_part"},{"id":"T27","span":{"begin":617,"end":622},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A23","pred":"uberon_id","subj":"T23","obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"A24","pred":"uberon_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A25","pred":"uberon_id","subj":"T25","obj":"http://purl.obolibrary.org/obo/UBERON_0002398"},{"id":"A26","pred":"uberon_id","subj":"T26","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"A27","pred":"uberon_id","subj":"T27","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"}],"text":"In addition, we determined viral titres in the lungs of infected animals (Figure S1). Our assays confirmed high RNA copy numbers and corresponding viral titres at early time points after infection followed by a rapid but incomplete clearance of the virus infection until 14 dpi. With titres of up to 5 × 107 pfu per 50 mg lung tissue and viral RNA copies in the range of up to 1 × 107 per 2.5 mg lung tissue at early time points after infection, we concluded that Chinese hamsters are highly susceptible to SARS‐CoV‐2. On the other hand, virus loads in blood samples were below 1 × 102 RNA copies per 2.5 µl of whole blood (15.6 ± 29.8 SD) at all time points, indicating lack of significant viremia and systemic infection (Figure 1e). These observations match findings from other animal models for emerging coronaviruses (Yuan et al., 2020)."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T53","span":{"begin":187,"end":196},"obj":"Disease"},{"id":"T54","span":{"begin":249,"end":264},"obj":"Disease"},{"id":"T55","span":{"begin":255,"end":264},"obj":"Disease"},{"id":"T56","span":{"begin":435,"end":444},"obj":"Disease"},{"id":"T57","span":{"begin":507,"end":511},"obj":"Disease"},{"id":"T58","span":{"begin":712,"end":721},"obj":"Disease"}],"attributes":[{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0005108"},{"id":"A55","pred":"mondo_id","subj":"T55","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A56","pred":"mondo_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A57","pred":"mondo_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A58","pred":"mondo_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"}],"text":"In addition, we determined viral titres in the lungs of infected animals (Figure S1). Our assays confirmed high RNA copy numbers and corresponding viral titres at early time points after infection followed by a rapid but incomplete clearance of the virus infection until 14 dpi. With titres of up to 5 × 107 pfu per 50 mg lung tissue and viral RNA copies in the range of up to 1 × 107 per 2.5 mg lung tissue at early time points after infection, we concluded that Chinese hamsters are highly susceptible to SARS‐CoV‐2. On the other hand, virus loads in blood samples were below 1 × 102 RNA copies per 2.5 µl of whole blood (15.6 ± 29.8 SD) at all time points, indicating lack of significant viremia and systemic infection (Figure 1e). These observations match findings from other animal models for emerging coronaviruses (Yuan et al., 2020)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T125","span":{"begin":47,"end":52},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T126","span":{"begin":65,"end":72},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"},{"id":"T127","span":{"begin":81,"end":83},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T128","span":{"begin":209,"end":210},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T129","span":{"begin":249,"end":254},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T130","span":{"begin":322,"end":326},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T131","span":{"begin":322,"end":326},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T132","span":{"begin":396,"end":400},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"},{"id":"T133","span":{"begin":396,"end":400},"obj":"http://www.ebi.ac.uk/efo/EFO_0000934"},{"id":"T134","span":{"begin":472,"end":480},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10026"},{"id":"T135","span":{"begin":538,"end":543},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T136","span":{"begin":553,"end":558},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T137","span":{"begin":553,"end":558},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T138","span":{"begin":582,"end":585},"obj":"http://purl.obolibrary.org/obo/CLO_0054060"},{"id":"T139","span":{"begin":611,"end":622},"obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"id":"T140","span":{"begin":611,"end":622},"obj":"http://www.ebi.ac.uk/efo/EFO_0000296"},{"id":"T141","span":{"begin":780,"end":786},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_33208"}],"text":"In addition, we determined viral titres in the lungs of infected animals (Figure S1). Our assays confirmed high RNA copy numbers and corresponding viral titres at early time points after infection followed by a rapid but incomplete clearance of the virus infection until 14 dpi. With titres of up to 5 × 107 pfu per 50 mg lung tissue and viral RNA copies in the range of up to 1 × 107 per 2.5 mg lung tissue at early time points after infection, we concluded that Chinese hamsters are highly susceptible to SARS‐CoV‐2. On the other hand, virus loads in blood samples were below 1 × 102 RNA copies per 2.5 µl of whole blood (15.6 ± 29.8 SD) at all time points, indicating lack of significant viremia and systemic infection (Figure 1e). These observations match findings from other animal models for emerging coronaviruses (Yuan et al., 2020)."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T6","span":{"begin":691,"end":698},"obj":"Phenotype"}],"attributes":[{"id":"A6","pred":"hp_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/HP_0020071"}],"text":"In addition, we determined viral titres in the lungs of infected animals (Figure S1). Our assays confirmed high RNA copy numbers and corresponding viral titres at early time points after infection followed by a rapid but incomplete clearance of the virus infection until 14 dpi. With titres of up to 5 × 107 pfu per 50 mg lung tissue and viral RNA copies in the range of up to 1 × 107 per 2.5 mg lung tissue at early time points after infection, we concluded that Chinese hamsters are highly susceptible to SARS‐CoV‐2. On the other hand, virus loads in blood samples were below 1 × 102 RNA copies per 2.5 µl of whole blood (15.6 ± 29.8 SD) at all time points, indicating lack of significant viremia and systemic infection (Figure 1e). These observations match findings from other animal models for emerging coronaviruses (Yuan et al., 2020)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T66","span":{"begin":86,"end":278},"obj":"Sentence"},{"id":"T67","span":{"begin":279,"end":518},"obj":"Sentence"},{"id":"T68","span":{"begin":519,"end":734},"obj":"Sentence"},{"id":"T69","span":{"begin":735,"end":841},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In addition, we determined viral titres in the lungs of infected animals (Figure S1). Our assays confirmed high RNA copy numbers and corresponding viral titres at early time points after infection followed by a rapid but incomplete clearance of the virus infection until 14 dpi. With titres of up to 5 × 107 pfu per 50 mg lung tissue and viral RNA copies in the range of up to 1 × 107 per 2.5 mg lung tissue at early time points after infection, we concluded that Chinese hamsters are highly susceptible to SARS‐CoV‐2. On the other hand, virus loads in blood samples were below 1 × 102 RNA copies per 2.5 µl of whole blood (15.6 ± 29.8 SD) at all time points, indicating lack of significant viremia and systemic infection (Figure 1e). These observations match findings from other animal models for emerging coronaviruses (Yuan et al., 2020)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"220","span":{"begin":464,"end":480},"obj":"Species"},{"id":"221","span":{"begin":507,"end":517},"obj":"Species"},{"id":"222","span":{"begin":807,"end":820},"obj":"Species"},{"id":"223","span":{"begin":56,"end":64},"obj":"Disease"},{"id":"224","span":{"begin":187,"end":196},"obj":"Disease"},{"id":"225","span":{"begin":249,"end":264},"obj":"Disease"},{"id":"226","span":{"begin":435,"end":444},"obj":"Disease"},{"id":"227","span":{"begin":691,"end":721},"obj":"Disease"}],"attributes":[{"id":"A220","pred":"tao:has_database_id","subj":"220","obj":"Tax:10029"},{"id":"A221","pred":"tao:has_database_id","subj":"221","obj":"Tax:2697049"},{"id":"A222","pred":"tao:has_database_id","subj":"222","obj":"Tax:11118"},{"id":"A223","pred":"tao:has_database_id","subj":"223","obj":"MESH:D007239"},{"id":"A224","pred":"tao:has_database_id","subj":"224","obj":"MESH:D007239"},{"id":"A225","pred":"tao:has_database_id","subj":"225","obj":"MESH:D001102"},{"id":"A226","pred":"tao:has_database_id","subj":"226","obj":"MESH:D007239"},{"id":"A227","pred":"tao:has_database_id","subj":"227","obj":"MESH:D014766"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In addition, we determined viral titres in the lungs of infected animals (Figure S1). Our assays confirmed high RNA copy numbers and corresponding viral titres at early time points after infection followed by a rapid but incomplete clearance of the virus infection until 14 dpi. With titres of up to 5 × 107 pfu per 50 mg lung tissue and viral RNA copies in the range of up to 1 × 107 per 2.5 mg lung tissue at early time points after infection, we concluded that Chinese hamsters are highly susceptible to SARS‐CoV‐2. On the other hand, virus loads in blood samples were below 1 × 102 RNA copies per 2.5 µl of whole blood (15.6 ± 29.8 SD) at all time points, indicating lack of significant viremia and systemic infection (Figure 1e). These observations match findings from other animal models for emerging coronaviruses (Yuan et al., 2020)."}